chondroitin-sulfates and Carbon-Monoxide-Poisoning

The glycosaminoglycans of the myocardium of an individual who died of acute carbon monoxide poisoning were quantified by two-dimensional electrophoresis on cellulose acetate membranes. The total glycosaminoglycan content was found to be approximately twice the normal value. In contrast to the content of each glycosaminoglycan of the normal heart, the level of the chondroitin sulfates of this patient's myocardium was found to be markedly increased whereas that of hyaluronic acid was decreased and dermatan sulfate could not be detected. Further, this tissue contained significant amounts of keratan sulfate and an oversulfated dermatan sulfate, glycosaminoglycans not found in normal myocardium. Of particular interest was the presence of two unusual oversulfated chondroitin sulfates (chondroitin sulfates D and E).

Topics: Adult; Carbon Monoxide Poisoning; Chondroitin; Chondroitin Sulfates; Dermatan Sulfate; Female; Glycosaminoglycans; Humans; Hyaluronic Acid; Keratan Sulfate; Myocardium; Tissue Distribution