chondroitin-sulfates and Ankle-Injuries

The prevalence of acellular dermal matrices in reconstructive surgery has increased through the last decade with satisfying outcomes. Long-term follow-up and effectiveness studies could enable appropriate use of these devices and challenge the current gold-standard treatments. This paper presents functional and cosmetic long-term outcomes on the Integra(®) Dermal Regeneration Template (IDRT) for treating traumatic soft-tissue defects of the foot and ankle.. All adult patients who underwent severe traumatic foot and ankle reconstruction with Integra(®) since 2004 were retrospectively included. Results were evaluated using standardized outcome instruments.. Twenty-one reconstructions were evaluated 4.5 ± 2.5 years after foot and ankle injury. Major complications inducing a second application included 1 hematoma and 1 infection. Seven patients (35%) had good or excellent Foot and Ankle Ability Measures. Subjectively, when asked to compare current function with pre-injury status, the mean response was 66 ± 23%. The Observer Scar Assessment Scale scored 17 ± 5 points (possible range, 5-50), while the Patient Scar Assessment Scale scored 30 ± 11 points (possible range, 6-60).. Long-term functional and cosmetic outcomes 4.5 years after severe traumatic foot and ankle wounds treated with IDRTs were rated fair in the great majority of patients. Nevertheless, because complications and surgical revisions were few, potential benefits might be underestimated because of the initial combined injuries and their sequelae. In this way, for appropriately selected patients with severe traumatic foot and ankle soft-tissue defects, including subacute coverage, it appears that this treatment may be a viable first option.

Topics: Adult; Ankle Injuries; Chondroitin Sulfates; Cicatrix; Collagen; Esthetics; Female; Foot Injuries; Humans; Male; Patient Outcome Assessment; Retrospective Studies; Skin, Artificial; Soft Tissue Injuries

Nowadays Integra™ is an integral part of the "reconstructive ladder", recently the new Integra™ Flowable Dermal Regeneration has appeared on the market. This is a semiliquid compound, malleable and those characteristics widen the indication for its use. In this report we describe two cases in which we used this product to repair undermined and tunnelled wounds. We believe that this product can be useful for treatment of tunnelled wounds of small dimensions reducing the need for major procedures.

Topics: Adult; Ankle Injuries; Chondroitin Sulfates; Collagen; Female; Forehead; Humans; Male; Middle Aged; Re-Epithelialization; Skin Transplantation; Skin, Artificial; Soft Tissue Injuries; Surgical Flaps; Young Adult

The successful use of Integra to cover a muscle flap as a secondary reconstructive procedure is presented.

Topics: Accidents, Traffic; Adolescent; Ankle Injuries; Biocompatible Materials; Chondroitin Sulfates; Collagen; Female; Fibula; Humans; Plastic Surgery Procedures; Surgical Flaps; Tibial Fractures; Treatment Outcome