chondroitin and Urinary-Calculi

The inhibitory capacity of pyrophosphate, citrate, magnesium and chondroitin sulphate was investigated, using the urine of 21 calcium oxalate stone-forming patients without metabolic alterations. The inhibitory effect of these substances was assessed by a combination of nephelometry (light scattering) and optical microscopy. The results showed that citrate and magnesium had an inhibitory effect in a significant number of cases. Pyrophosphate and chondroitin sulphate had a less marked effect. The main urinary lithogenic biochemical parameters of the patients were also studied to see if there was a relationship between them and the inhibitory capacity of the compounds.

Topics: Calcium Oxalate; Chondroitin; Chondroitin Sulfates; Citrates; Citric Acid; Crystallization; Diphosphates; Humans; Magnesium; Urinary Calculi

Opinions vary on the effects produced by urinary inhibitors of crystallisation. We describe a simple method for studying inhibitory effects in urine based on nephelometry and optical microscopy. It was concluded that the inhibitory effect of a given substance on calcium oxalate crystallisation depends on the particular sample of urine being examined and that the most effective inhibitor can be determined only by studying the urine of each patient individually.

Topics: Calcium Oxalate; Chondroitin; Chondroitin Sulfates; Citrates; Crystallization; Diphosphates; Humans; Magnesium; Nephelometry and Turbidimetry; Urinary Calculi

Topics: Aged; Alkaptonuria; Chondroitin; Humans; Male; Ochronosis; Urinary Calculi