chondroitin and Syndrome

Topics: Adolescent; Alkaline Phosphatase; Child; Child, Preschool; Chondrodysplasia Punctata; Chondroitin; Diagnosis, Differential; Female; Fractures, Spontaneous; Humans; Hyperostosis, Cortical, Congenital; Male; Middle Aged; Mucopolysaccharidoses; Osteitis Deformans; Osteoarthropathy, Primary Hypertrophic; Osteopetrosis; Osteosclerosis; Phosphoric Monoester Hydrolases; Radiography; Skin Diseases; Syndrome

The aim of the study was to compare Cistiquer, a new phytotherapeutic product developed for chronic bladder inflammatory diseases, and intra-vesical administration of gentamicin plus betametasone, in females with urethral syndrome.. Between september 2013 and may 2014, 60 women with urethral syndrome and trigonitis were incuded in this study. Patients were randomly assigned to treatment with intra-vesical administration of betametasone 8 mg plus gentamicin 80 mg (group A), and oral administration of Cistiquer (group B) for 7 weeks. Before and after the therapeutic protocol, symptoms were assessed by three days voiding diary, the overactive bladder questionnaire short form and a ten points visual analogic scale adopted to assess the micturition discomfort. Histologic findings were assessed by the examination of specimens obtained by cold bladder biopsies of the bladder trigone at baseline in all the subjects.. The two groups had significant and comparable symptoms improvement. However, the score obtained from the visual analogic scale decreased significantly only in the group submitted to oral therapy. Furthermore, in the group treated with endovesical approach, higher drop out rate and higher incidence of urinary infection were observed.. Patients with urethral syndrome and trigonitis improved symptoms either with oral therapy with Cistiquer and with intra-vesical administration of gentamicin plus betametasone. However, treatment adherence resulted higher for patients treated by oral therapy and rate of adverse events resulted higher for those submitted to endovesical treatment.

Topics: Adult; Betamethasone; Bromelains; Chondroitin; Drug Therapy, Combination; Female; Gentamicins; Glucocorticoids; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Phytotherapy; Plant Extracts; Prospective Studies; Quercetin; Surveys and Questionnaires; Syndrome; Urethral Diseases

To describe and identify unknown opaque material between the optic of an AR40 intraocular lens (IOL) injected with the Emerald Series implantation system (both AMO, Inc.) and the posterior capsule at the conclusion of routine phacoemulsification to prevent an outbreak of toxic anterior segment syndrome (TASS).. Ambulatory care center operating room, University of North Carolina Hospitals and Department of Ophthalmology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina, USA.. After coaxial phacoemulsification in multiple patients, opaque material was present between the optic of a posterior chamber IOL and the posterior capsule. Although there was no TASS, the material was removed from 2 eyes and analyzed with scanning electron microscopy (SEM) and x-ray microanalysis (XRM). Similarly, crystalline lens, Klenzyme (Steris Corp.), Viscoat (sodium hyaluronate 3.0%-chondroitin sulfate 4.0%), and Provisc (sodium hyaluronate 1.0%) were analyzed.. On SEM, the material had an irregular undulating surface similar to that of Provisc. Viscoat and the crystalline lens had smoother surfaces. On XRM, the material contained sodium, chlorine, and calcium, like Viscoat and Provisc, and phosphorous and sulfur, like Viscoat. The material also contained silicone, magnesium, aluminum, titanium, iron, and zinc. Klenzyme had smaller peaks of sodium, chlorine, and calcium and a higher carbon background than the unknown material.. The material was likely ophthalmic viscosurgical device that was chemically and structurally altered by the cleaning and sterilization process. The silicone and metallic elements were probably from the Emerald Series implantation system as the disposable cartridge is coated with silicone and the reusable injector is metal.

Topics: Anterior Eye Segment; Chondroitin; Chondroitin Sulfates; Drug Combinations; Electron Probe Microanalysis; Foreign-Body Reaction; Humans; Hyaluronic Acid; Lens Capsule, Crystalline; Lens Implantation, Intraocular; Microscopy, Electron, Scanning; Phacoemulsification; Postoperative Complications; Syndrome; Uveitis, Anterior

I describe a technique using ophthalmic viscosurgical devices to perform cataract surgery in patients taking tamsulosin (Flomax). The 6-step method uses a combination variant of the soft-shell and ultimate soft-shell techniques and involves adjustments to flow parameters. It achieves satisfactory iris stability and permits uneventful surgery.

Topics: Acetates; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anterior Chamber; Chondroitin; Chondroitin Sulfates; Drug Combinations; Humans; Hyaluronic Acid; Intraoperative Complications; Iris Diseases; Lens Implantation, Intraocular; Minerals; Phacoemulsification; Pupil; Sodium Chloride; Sulfonamides; Syndrome; Tamsulosin

The immunohistological localization of chondroitin sulfate (CS) has been studied in normal and pathological human muscle. The bovine nasal cartilage proteoglycan digested with chondroitinase ABC (BNC-PG-Ch ABC) has been utilized for the production of a rabbit polyclonal antiserum. In vitro studies showed that the antiserum binds to the unsaturated disaccharide that remains attached to the core protein after digestion of the CS chains with chondroitinase ABC (Ch ABC). As the disaccharide is created specifically by Ch ABC digestion of the CS chains, the antiserum allows the immunolocalization of CS on tissue sections digested with Ch ABC. The immunohistochemical study on normal and pathological muscle demonstrated a localization of CS in all the extracellular structures: endomysium, perimysium, muscle spindle capsule and intrafusal space. In pathological conditions, the CS was raised in all the cases with increased connective tissue, showing a pattern comparable to that obtained with fibronectin and collagen III. None of the pathological conditions displayed any peculiar character of CS distribution. This finding does not support a primary role for CS in the pathogenesis of muscular dystrophy.

Topics: Antibody Specificity; Blood Vessels; Chondroitin; Chondroitin Sulfates; Humans; Muscles; Muscular Dystrophies; Neuromuscular Diseases; Syndrome

The properties of [35S]sulfate-labeled proteoglycans secreted by normal human skin fibroblasts were compared with those synthesized by fibroblasts from three patients with Coffin-Lowry syndrome. 60-80% of secreted radioactive macromolecules from normal fibroblasts were eluted from a Sepharose CL-4B column with a mean Kav-value of 0.56 (pool 2); 3-10% of the radioactivity appeared in the exclusion volume of the column (pool 1). In contrast, 17-60% of the proteoglycans from the patients were found in the void volume. The bulk of remaining material was eluted with a mean Kav-value of 0.47. Pool 2 glycan chains from two patients exhibited an increased hydrodynamic size. Pool 1 from normal cells contained predominantly a glucuronic acid-rich proteodermatan sulfate, iduronic acid amounting for approximately 20% of glucuronic acid. In the respective proteodermatan sulfate from the patients, the relative iduronic acid content was at least 33% of that of glucuronic acid. Pool 2 material of all cell lines was characterized predominantly as iduronic acid-rich proteodermatan sulfate. In the proteoglycans from two patients the content of chondroitin 4-sulfate-derived disaccharides was increased at the expense of 6-sulfated chondroitin disaccharides. Native proteoglycans from the patients were less efficiently endocytosed by fibroblasts than their normal counterparts. Coffin-Lowry fibroblasts had a normal capability to synthesize glycosaminoglycan chains on an artificial acceptor, p-nitrophenyl-beta-D-xyloside. They were also normal in 3'-phosphoadenylylsulfate: chondroitin 4- and 6-sulfotransferase activities.

Topics: Abnormalities, Multiple; Adult; Bone and Bones; Cells, Cultured; Child, Preschool; Chondroitin; Dermatan Sulfate; Fibroblasts; Glucuronates; Glucuronic Acid; Humans; Iduronic Acid; Intellectual Disability; Male; Proteoglycans; Sex Factors; Skin; Skin Diseases; Syndrome

Urinary mucopolysaccharides from three patients with acheiropodia were qualitatively and quantitatively analysed by agar gel electrophoresis coupled with enzymatic degradation. Although no abnormal pattern was characterized, eventual metabolic dysfunction detected only in bone/cartilage tissues could not be ruled out.

Topics: Abnormalities, Multiple; Adolescent; Adult; Child; Chondroitin; Chondroitin Sulfates; Foot Deformities, Congenital; Hand Deformities, Congenital; Humans; Syndrome

Topics: Cells, Cultured; Chondroitin; Fibroblasts; Humans; Immunodiffusion; Liver; Mucopolysaccharidoses; Mutation; Skin; Sulfatases; Syndrome

Myelopathy due to compression of the cervical spinal cord by thickened dura developed in a patient with Maroteaux-Lamy syndrome. During the last trimester of pregnancy there was severe neurological deterioration with spastic quadriparesis and impairment of sphincter function. Two months after delivery ther had been no improvement, so a cervical laminectomy and longitudinal splitting of the dura from C-5 to the foramen magnum was done. Good return of function resulted.

Topics: Adult; Carpal Tunnel Syndrome; Cervical Vertebrae; Chondroitin; Dura Mater; Female; Humans; Mucopolysaccharidoses; Pregnancy; Pregnancy Complications; Spinal Cord Compression; Syndrome

Topics: Chondroitin; Diagnosis, Differential; Female; Galactosidases; Glycoside Hydrolases; Heterozygote; Hexosaminidases; Humans; Iduronidase; Leukocytes; Male; Mucopolysaccharidoses; Mucopolysaccharidosis I; Mucopolysaccharidosis III; Syndrome

Topics: Adult; Child; Child, Preschool; Chondroitin; Female; Hand; Hand Deformities, Acquired; Humans; Intellectual Disability; Male; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Occupational Therapy; Radiography; Retinitis Pigmentosa; Syndrome

Topics: Chondroitin; Diagnosis, Differential; Humans; Intellectual Disability; Lectins; Lymphocytes; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Retinitis Pigmentosa; Sulfates; Sulfur Radioisotopes; Syndrome; Thymidine; Tritium

Topics: Biopsy; Chondroitin; Fibroblasts; Hexosamines; Humans; Intellectual Disability; Leukodystrophy, Metachromatic; Lysosomes; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Skin; Sulfatases; Syndrome

Topics: Cells, Cultured; Chondroitin; Fibroblasts; Galactosamine; Humans; Intellectual Disability; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Retinitis Pigmentosa; Skin; Sulfatases; Sulfuric Acids; Syndrome

Topics: Blood Transfusion; Child Care; Child, Preschool; Chondroitin; Education of Intellectually Disabled; Enzyme Therapy; Female; Human Rights; Humans; Infant; Leukocyte Transfusion; Male; Mucopolysaccharidoses; Retinitis Pigmentosa; Syndrome; Transplantation, Homologous

Topics: Bone Diseases, Developmental; Chondroitin; Electroretinography; Face; Fibroblasts; Fundus Oculi; Genetic Variation; Glycosaminoglycans; Hearing Disorders; Heparin; Humans; Intelligence; Male; Mucopolysaccharidoses; Pigmentation Disorders; Radiography; Skin; Sulfatases; Sulfates; Syndrome; Visual Acuity

Topics: Acetamides; Borohydrides; Cartilage; Chondroitin; Chromatography, Gas; Evaluation Studies as Topic; Galactosamine; Glucosamine; Glycosaminoglycans; Humans; Hyaluronic Acid; Intellectual Disability; Methods; Mucopolysaccharidoses; Sulfuric Acids; Syndrome; Time Factors

Topics: Carbohydrate Metabolism, Inborn Errors; Cell Line; Cells, Cultured; Chondroitin; Chromatography, DEAE-Cellulose; Chromatography, Gel; Fibroblasts; Galactosidases; Glucosidases; Glucuronidase; Glycosaminoglycans; Glycoside Hydrolases; Hexosaminidases; Humans; Lysosomes; Mucopolysaccharidoses; Sulfatases; Sulfur Radioisotopes; Syndrome; Uronic Acids

Topics: Blood Transfusion; Chondroitin; Corneal Opacity; Glycosaminoglycans; Humans; Mucopolysaccharidoses; Mucopolysaccharidosis I; Mucopolysaccharidosis IV; Retinitis Pigmentosa; Sulfates; Syndrome

Topics: Adult; Basement Membrane; Biopsy; Chondroitin; Conjunctiva; Connective Tissue Cells; Cornea; Corneal Opacity; Cytoplasm; Epithelial Cells; Fibroblasts; Glycosaminoglycans; Histiocytes; Histocytochemistry; Humans; Inclusion Bodies; Joint Diseases; Male; Microscopy, Electron; Mucopolysaccharidoses; Phenotype; Plasma Cells; Retinitis Pigmentosa; Schwann Cells; Syndrome

Topics: Chondroitin; Craniofacial Dysostosis; Dwarfism; Famous Persons; France; History, 19th Century; History, 20th Century; Humans; Paintings; Syndrome

Topics: Bone Diseases; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Chondroitin; Connective Tissue; Gingival Hypertrophy; Glycosaminoglycans; Histocytochemistry; Humans; Infant; Infant, Newborn; Joint Diseases; Male; Methods; Skin; Skin Diseases; Skin Neoplasms; Staining and Labeling; Syndrome

Topics: Child; Child, Preschool; Chondroitin; Consanguinity; Corneal Opacity; Female; Glycosaminoglycans; Heparitin Sulfate; Humans; Male; Mucopolysaccharidoses; Syndrome

Topics: Carbohydrate Metabolism, Inborn Errors; Cells, Cultured; Chondroitin; Conjunctiva; Cornea; Corneal Opacity; Electrophoresis; Fibroblasts; Glycosaminoglycans; Histocytochemistry; Humans; Hyaluronic Acid; Intellectual Disability; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Retinitis Pigmentosa; Skin; Syndrome; Uronic Acids

Topics: Adolescent; Adult; Age Factors; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Chondroitin; Electrophoresis; Female; Glycosaminoglycans; Heparin; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Mucopolysaccharidoses; Puberty; Retinitis Pigmentosa; Sex Factors; Syndrome

Topics: Adult; Carbohydrate Metabolism, Inborn Errors; Chondroitin; Eczema; Female; Fibroma; Glycosaminoglycans; Hip Dislocation, Congenital; Humans; Mucopolysaccharidosis I; Muscle Spasticity; Nevus, Pigmented; Psoriasis; Quadriplegia; Retinitis Pigmentosa; Skin Neoplasms; Syndrome

Topics: Adolescent; Chondroitin; Corneal Opacity; Craniofacial Dysostosis; Diagnosis, Differential; Dwarfism; Encephalocele; Female; Humans; Mucopolysaccharidoses; Pneumoencephalography; Syndrome

Topics: Arachnodactyly; Bone and Bones; Brain; Cartilage; Child; Chondroitin; Glycosaminoglycans; Humans; Kidney; Liver; Marfan Syndrome; Metabolism; Mucopolysaccharidosis I; Spleen; Syndrome