chondroitin and Pseudoxanthoma-Elasticum

Abnormally elevated hyaluronic acid and dermatan sulfate were isolated from lesional skin of a patient with severe pseudoxanthoma elasticum. These glycosaminoglycans (estimated as uronic acid) surpassed the normal controls by 33.6 and 4.8 magnitudes, respectively. Urine chondroitin 6-sulfate of the same patient moved faster by electrophoresis on cellulose acetate than its counterpart isolated from urine of another four patients or from the normal controls. Hyaluronic acid and chondroitin 6-sulfate exceeded their counterparts in normal urine by 2- to 10- and 4- to 18-folds, respectively. These increments correlated with the pseudoxanthoma elasticum severity in three of the five patients studied. The data showed: the first conclusive evidence that dermatan sulfate increased in lesional skin of a patient, with severe pseudoxanthoma elasticum, who also had considerably augmented HA, alteration of the same patient's urine chondroitin 6-sulfate, and diversified urine glycosaminoglycans in pseudoxanthoma elasticum.

Topics: Adult; Chondroitin; Chondroitin Sulfates; Dermatan Sulfate; Electrophoresis, Cellulose Acetate; Female; Fluorescent Antibody Technique; Glycosaminoglycans; Humans; Hyaluronic Acid; Male; Middle Aged; Pseudoxanthoma Elasticum; Skin

Topics: Administration, Cutaneous; Chondroitin; Galactose; Glucosamine; Glycosaminoglycans; Hexosamines; Histocytochemistry; Humans; Hyaluronic Acid; Pseudoxanthoma Elasticum; Skin