chondroitin and Neoplasms

Topics: Arthritis; Chondroitin; Common Cold; Consumer Product Safety; Dietary Supplements; Evidence-Based Medicine; Fish Oils; Garlic; Glucosamine; Glycine max; Heart Diseases; Humans; Hypertension; Menopause; Neoplasms; Phytotherapy; Research Design; Tea; Zinc Compounds

Topics: Acid Phosphatase; Animals; Aprotinin; Basement Membrane; Carcinoma; Cell Division; Chondroitin; Culture Techniques; Esterases; Glucuronidase; Histocytochemistry; Humans; Hyaluronic Acid; Isoenzymes; Lysosomes; Microscopy, Electron; Neoplasms; Oncogenic Viruses; Papilloma; Pinocytosis; Sulfatases; Vitamin A

Topics: Age Factors; Atmospheric Pressure; Burns; Carbohydrate Metabolism, Inborn Errors; Chondroitin; Connective Tissue; Corneal Opacity; Glomerular Filtration Rate; Glycosaminoglycans; Humans; Intellectual Disability; Lupus Erythematosus, Systemic; Mucopolysaccharidosis IV; Neoplasms; Retinitis Pigmentosa

Topics: Acetamides; Azo Compounds; Biological Transport, Active; Carcinogens; Carcinoma, Hepatocellular; Cells, Cultured; Chondroitin; Ethionine; Glucose; Glycogen; Glycosaminoglycans; Heparin; Histocytochemistry; Hyaluronic Acid; Liver; Liver Glycogen; Liver Neoplasms; Microscopy, Electron; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Nitrosamines; Polysaccharides; Radiation Effects

Topics: Adult; Chondroitin; Glucosamine; Humans; Neoplasms; Nutrition Surveys; Prospective Studies; United States

Glucosamine and chondroitin are products commonly used by older adults in the US and Europe. There is limited evidence that they have anti-inflammatory properties, which could provide risk reduction of several diseases. However, data on their long-term health effects is lacking. To evaluate whether use of glucosamine and chondroitin are associated with cause-specific and total mortality. Participants (n = 77,510) were members of a cohort study of Washington State (US) residents aged 50-76 years who entered the cohort in 2000-2002 by completing a baseline questionnaire that included questions on glucosamine and chondroitin use. Participants were followed for mortality through 2008 (n = 5,362 deaths). Hazard ratios (HR) for death adjusted for multiple covariates were estimated using Cox models. Current (baseline) glucosamine and chondroitin use were associated with a decreased risk of total mortality compared to never use. The adjusted HR associated with current use of glucosamine (with or without chondroitin) was 0.82 (95 % CI 0.75-0.90) and 0.86 (95 % CI 0.78-0.96) for chondroitin (included in two-thirds of glucosamine supplements). Current use of glucosamine was associated with a significant decreased risk of death from cancer (HR 0.87 95 % CI 0.76-0.98) and with a large risk reduction for death from respiratory diseases (HR 0.59 95 % CI 0.41-0.83). Use of glucosamine with or without chondroitin was associated with reduced total mortality and with reductions of several broad causes of death. Although bias cannot be ruled out, these results suggest that glucosamine may provide some mortality benefit.

Topics: Aged; Anti-Inflammatory Agents; Cause of Death; Chondroitin; Dietary Supplements; Female; Follow-Up Studies; Glucosamine; Humans; Male; Middle Aged; Mortality; Neoplasms; Proportional Hazards Models; Prospective Studies; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Washington

The use of complimentary and alternative medicine is on the rise. This article reviews some of the commonly used herbal supplements and others focusing mainly on disease prevention. A summary table of medical conditions is provided, and when possible, a summary of efficacy and safety is provided to facilitate decision making.

Topics: Camellia sinensis; Cardiovascular Diseases; Carotenoids; Chondroitin; Cimicifuga; Dietary Supplements; Echinacea; Fish Oils; Flax; Glucosamine; Humans; Inflammatory Bowel Diseases; Lutein; Lycopene; Neoplasms; Plant Preparations; Primary Health Care; Primary Prevention; Probiotics; Silybum marianum; United States; Vaccinium macrocarpon; Zingiber officinale

Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and delta Di-6S binding to core protein via a linkage tetrasaccharide, respectively. The antibody 6B6 raised against dermatan sulphate PG obtained from an ovarian fibroma capsule in our laboratory was also used. The interstitial fibrous elements, so-called 'specific stroma' within the cancer cell nests contained chondroitin 4-sulphate PG as revealed with 9A-2, whereas the surrounding connective tissue and the preexisting fibrous connective tissue involved in the tumour growth consisted of dermatan sulphate PG with a considerable amount of chondroitin 4-sulphate PG. Chondroitin 6-sulphate PG as revealed with 3B-3 was located in the connective tissue proliferating from blood vessels and muscle tissue in association with the invasive growth of tumour cells. Chondroitin 6-sulphate PG was also observed in the basement membrane components of some tumours. In non-epithelial tumours (fibrogenic, chondrogenic, osteogenic and neurogenic tumours), chondroitin 4-sulphate was in fibrous portions. When collagenization and hyalinization progressed, dermatan sulphate PG was observed to increase in quantity.

Topics: Aggrecans; Antibodies, Monoclonal; Chondroitin; Chondroitin Sulfate Proteoglycans; Connective Tissue; Dermatan Sulfate; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Immunohistochemistry; Lectins, C-Type; Neoplasm Proteins; Neoplasms; Proteoglycans

Topics: Animals; Binding Sites; Brain; Cell Adhesion; Cell Aggregation; Chondroitin; Chondroitin Sulfates; Dermatan Sulfate; Glycosaminoglycans; Guinea Pigs; Heparitin Sulfate; Humans; Ileum; Kidney; Molecular Weight; Muscles; Neoplasms; Organ Specificity; Rabbits; Species Specificity

The distribution of sulfated mucopolysaccharides in different tissues during growth and in cancer tissues is reported. It is shown that most of the tissues of 1 day-old rats and rabbits contain chondroitin sulfate A/C, chondroitin sulfate B and heparan sulfate in about the same proportions, whereas in adult animals chondroitin sulfate A/C decreases in concentration or disappears. Changes in the relative proportions of chondroitin sulfate B and heparan sulfate were also observed in most of the tissues. In rats, these changes occur in the first 25 days of extrauterine development. A great increase of chondroitin sulfate A/C was observed in human tumors of different origins when compared with the normal adjacent tissues. Changes in the relative proportions of chondroitin sulfate B and heparan sulfate were also observed in most of the tumors analysed. The possible role of chondroitin sulfate A/C in cell division is discussed in view of the present findings.

Topics: Aging; Animals; Animals, Newborn; Brain; Chondroitin; Chondroitin Sulfates; Glycosaminoglycans; Guinea Pigs; Heparitin Sulfate; Humans; Kidney; Liver; Neoplasms; Organ Specificity; Rabbits; Rats; Species Specificity

Topics: Animals; Arthritis, Rheumatoid; Chondroitin; Electrophoresis, Disc; Female; Glycosaminoglycans; Glycoside Hydrolases; Humans; Hyaluronic Acid; Hydrogen-Ion Concentration; Male; Myocardial Infarction; Neoplasms; Pregnancy; Sharks; Skin; Sulfuric Acids; Swine; Trachea

The presence of mucopolysaccharides (MPS) in leucocytes of peripheral blood of 19 cancer patients, 13 patients with pulmonary tuberculosis and 14 normal controls, was studied histochemically. MPS was revealed in different proportions in polynuclears and mononuclears. According to the staining technics, the MPS appear to be mainly carboxylated and contain hyaluronic acid and chondroitinsulphate groups.The quantitative analysis revealed that MPS appeared only in around 3% of leucocytes of normal controls, while in the cancer patients 56% of polynuclear and 90% of mononuclears contained it. In the tuberculous patients, 90% of polynuclears and 86% of the mononuclears revealed MPS. The differences between the prevalence of leucocytes containing MPS in controls and in cancer or tuberculous patients are highly significant.The possibility that the difference in MPS content of leucocytes is related with low inmunological activity is postulated.

Topics: Adolescent; Adult; Aged; Carboxylic Acids; Chondroitin; Female; Glycosaminoglycans; Histocytochemistry; Humans; Hyaluronic Acid; Leukocytes; Lymphocytes; Male; Middle Aged; Neoplasms; Neutrophils; Tuberculosis, Pulmonary

Topics: Body Fluids; Chemistry Techniques, Analytical; Chondroitin; Exudates and Transudates; Glycosaminoglycans; Humans; Hyaluronic Acid; In Vitro Techniques; Mesothelioma; Neoplasms

Topics: Animals; Blood Chemical Analysis; Carbohydrates; Cattle; Chondroitin; Chromatography; Electrophoresis; Female; Hexosamines; Humans; Hyaluronic Acid; Neoplasms; Neuraminic Acids; Peptides; Spectrophotometry; Submandibular Gland; Urine; Uronic Acids; Uterine Cervical Neoplasms

Topics: Chondroitin; Chromatography; Electrophoresis; Female; Glycosaminoglycans; Heparin; Humans; Hyaluronic Acid; Neoplasms; Neuraminic Acids; Peptides; Proteinuria; Uterine Cervical Neoplasms

Topics: Antineoplastic Agents; Chick Embryo; Chloroquine; Chondroitin; Connective Tissue; Fibroblasts; Granuloma; Microscopy; Microscopy, Phase-Contrast; Myocardium; Neoplasms; Orotic Acid; Pharmacology; Rats; Research; Tissue Culture Techniques; Uronic Acids

Topics: Chondroitin; Chondroitin Sulfates; Humans; Ions; Neoplasms; Sensitivity and Specificity; Sulfates

Topics: Amino Sugars; Chondroitin; Heparin; Hyaluronic Acid; Neoplasms; Polysaccharides