chondroitin and Joint-Diseases

Topics: Adolescent; Bone and Bones; Carbohydrate Metabolism, Inborn Errors; Child, Preschool; Chondroitin; Chromosome Aberrations; Chromosome Disorders; Female; Fetus; Glycolipids; Glycosaminoglycans; Humans; Hypertrichosis; Infant; Intellectual Disability; Joint Diseases; Male; Microscopy, Electron; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Retinitis Pigmentosa

Topics: Animals; Cartilage, Articular; Chondroitin; Disease Models, Animal; Glycosaminoglycans; Humans; Hydrocortisone; Joint Diseases; Microscopy, Electron; Papain; Rabbits; Sulfates; Synovial Membrane; Synovitis; Vitamin A

Topics: Autopsy; Carbohydrate Metabolism, Inborn Errors; Chondroitin; Chromosome Aberrations; Chromosome Disorders; Dwarfism; Fibroblasts; Glycosaminoglycans; Histocytochemistry; Humans; Hyaluronic Acid; Intellectual Disability; Joint Diseases; Metaplasia; Microscopy, Electron; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Osteochondritis; Retinitis Pigmentosa

Topics: Biochemical Phenomena; Biochemistry; Cartilage; Chondroitin; Humans; Hyaluronic Acid; Joint Diseases; Synovial Fluid; Synovial Membrane

Topics: Chondroitin; Chondroitin Sulfates; Clinical Trials as Topic; Drug Evaluation; Humans; Joint Diseases

The first case of a myxoid chondrosarcoma, originating in the synovia of the joint and tendon sheaths of the ankle in a 37-year-old man, is reported. Light microscopically the tumor was similar to extraskeletal myxoid chondrosarcoma as previously described. The chondromatous nature of the tumor was further indicated by the histochemical analysis, which revealed the presence of chondroitin 4- and 6-sulphate in the tumor matrix. Ultrastructurally, chondroblast-like cells with dilated rough endoplasmic reticulum, abundant glycogen, some lipid droplets and numerous microvilli-like projections of the cytoplasm dominated. Also mitochondria-rich cells were observed as well as intermediate cell forms. Based on the observations in this case, the frequent occurrence of synovial chondromatosis, the assumed synovial origin of extraskeletal chondromas and the wide morphologic and functional spectrum synovial intima cells may cover, it is suggested that the myxoid chondrosarcoma originated from the synovial intima cells.

Topics: Adult; Ankle Joint; Cell Nucleus; Chondroitin; Chondroitin Sulfates; Chondrosarcoma; Cytoplasm; Endoplasmic Reticulum; Histocytochemistry; Humans; Joint Diseases; Male; Microvilli; Synovial Membrane

Topics: Anti-Inflammatory Agents; Chondroitin; Chondroitin Sulfates; Humans; Joint Diseases; Neuritis

Glycosaminoglycans were isolated from the urines of 46 patients with mucopolysaccharidosis; 11 with Type I (Hurler), 8 with Type II (Hunter), 16 with Type III (Sanfilippo A and B), 9 with Type V (Scheie), one with Type VI (Marateaux-Lamy), and one unclassified. All 46 patients excreted in their urine excessive amounts of dermatan sulfate, heparan sulfate or both. In addition, patients of certain types excreted excessive amounts of chondroitin sulfates A and/or C. There is a trend in each type of the disease towards the same carbazole/orcinol ratio, glucosamine/galactosamine ratio and glycosaminoglycan composition. Molecular weight distribution of the urinary glycosaminoglycans by gel filtration from Sephadex G-200 is characteristic for each different type of mucopolysaccharidosis and is distinguished from normal controls and patients without mucopolysaccharidosis. Preparation of elution diagrams from Sephadex G-200 allows an estimation of the composition of the glycosamino-glycans. Practically all heparan sulfate and a sizable part of dermatan sulfate from the urinary glycosaminoglycans of all these patients have been highly degraded. In all the patients in which the specific enzyme defect was demonstrated, the assignment of the type of mucopolysaccharidosis, on the basis of the elution diagrams, was correct. Patients with mucopolysaccharidosis Type V displayed two conspicuously different types of elution patterns, suggesting heterogeneity. Indeed, only a portion of these patients showed alpha-L- iduronidase deficiency. Carriers had normal urinary glycosaminoglycan output and composition and exhibited normal elution diagrams.

Topics: Adolescent; Adult; Bone and Bones; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Chondroitin; Dermatan Sulfate; Female; Glycosaminoglycans; Heparitin Sulfate; Humans; Hypertrichosis; Infant; Intellectual Disability; Joint Diseases; Male; Mucopolysaccharidoses; Mucopolysaccharidosis I; Mucopolysaccharidosis II; Retinitis Pigmentosa

Topics: Adult; Basement Membrane; Biopsy; Chondroitin; Conjunctiva; Connective Tissue Cells; Cornea; Corneal Opacity; Cytoplasm; Epithelial Cells; Fibroblasts; Glycosaminoglycans; Histiocytes; Histocytochemistry; Humans; Inclusion Bodies; Joint Diseases; Male; Microscopy, Electron; Mucopolysaccharidoses; Phenotype; Plasma Cells; Retinitis Pigmentosa; Schwann Cells; Syndrome

Topics: Bone Diseases; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Chondroitin; Connective Tissue; Gingival Hypertrophy; Glycosaminoglycans; Histocytochemistry; Humans; Infant; Infant, Newborn; Joint Diseases; Male; Methods; Skin; Skin Diseases; Skin Neoplasms; Staining and Labeling; Syndrome

Topics: Administration, Oral; Animals; Cartilage, Articular; Chondroitin; Cyclohexanecarboxylic Acids; Depression, Chemical; Drug Evaluation; Hexosamines; Injections, Intra-Articular; Joint Diseases; Methylamines; Rabbits; Stimulation, Chemical; Sulfur Radioisotopes; Tablets

Topics: Bone and Bones; Carbohydrate Metabolism, Inborn Errors; Chondroitin; Chromatography; Chromosome Aberrations; Chromosome Disorders; Glycosaminoglycans; Humans; Hypertrichosis; Intellectual Disability; Joint Diseases; Mucopolysaccharidoses; Retinitis Pigmentosa

Topics: Arthritis, Rheumatoid; Binding Sites; Cartilage, Articular; Chondroitin; Glycosaminoglycans; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Joint Diseases; Joints; Synovial Fluid; Viscosity

Topics: Adrenal Cortex Hormones; Analgesics; Anti-Inflammatory Agents; Baths; Chondroitin; Electric Stimulation Therapy; Glycosaminoglycans; Humans; Joint Diseases; Osteoarthritis; Physical Therapy Modalities; Tranquilizing Agents; Ultrasonic Therapy

Topics: Acrylamides; Animals; Aorta; Artiodactyla; Cartilage, Articular; Centrifugation, Density Gradient; Chondroitin; Densitometry; Drug Stability; Electrophoresis; Female; Gels; Glycoproteins; Glycosaminoglycans; Humans; Hyaluronic Acid; Joint Diseases; Keratins; Molecular Weight; Polysaccharides; Pregnancy; Solubility; Sulfuric Acids; Swine; Umbilical Cord

Topics: Arthritis, Rheumatoid; Bone Marrow; Cartilage; Chondroitin; Drug Eruptions; Humans; Joint Diseases; Organotherapy; Rheumatic Diseases; Spinal Osteophytosis; Sulfates; Urticaria

Topics: Animals; Cartilage, Articular; Chondroitin; Guinea Pigs; Joint Diseases; Keratins

Topics: Amino Acids; Aspartic Acid; Bone and Bones; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Chondroitin; Chromatography, Ion Exchange; Female; Galactosamine; Glucosamine; Glutamates; Glycine; Glycosaminoglycans; Humans; Hypertrichosis; Joint Diseases; Male; Mucopolysaccharidosis I; Retinitis Pigmentosa; Serine; Uronic Acids

Topics: Adolescent; Bone and Bones; Carbohydrate Metabolism, Inborn Errors; Child; Chondroitin; Corneal Opacity; Female; Heparin; Humans; Hypertrichosis; Intellectual Disability; Joint Diseases; Male; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Retinitis Pigmentosa

Topics: Biomechanical Phenomena; Cartilage Diseases; Cartilage, Articular; Chondroitin; Glycosaminoglycans; Humans; Hydroxyproline; Joint Diseases; Keratins

Topics: Adult; Age Factors; Aged; Anesthesia, General; Biopsy; Bone and Bones; Calcinosis; Cervical Vertebrae; Chondroitin; Chromatography, Ion Exchange; Contrast Media; Diabetes Complications; Female; Femur Head; Glycosaminoglycans; Hexosamines; Humans; Humerus; Hyaluronic Acid; Immobilization; Joint Diseases; Male; Manipulation, Orthopedic; Microscopy; Microscopy, Electron; Middle Aged; Movement; Radiography; Seasons; Sex Factors; Shoulder; Shoulder Injuries; Shoulder Joint; Strontium Isotopes; Synovial Fluid

Topics: Adult; Cartilage, Articular; Chondroitin; Ear Deformities, Acquired; Female; Fluorescent Antibody Technique; Glycosaminoglycans; Humans; Joint Diseases; Male; Middle Aged; Nose Deformities, Acquired; Photomicrography

Topics: Cartilage, Articular; Chondroitin; Humans; Joint Diseases

Topics: Achilles Tendon; Blood Protein Electrophoresis; Chondroitin; Elbow; Elbow Joint; Genetics, Medical; Hand; Humans; Hypercholesterolemia; Joint Diseases; Leg; Patella; Tibia; Xanthomatosis