chondroitin and Inflammation

Topics: Acute Disease; Animals; Chondroitin; Female; Glycoproteins; Glycosaminoglycans; Hyaluronic Acid; Inflammation; Neuraminic Acids; Rats

Topics: Ascorbic Acid; Carbon Isotopes; Chemistry Techniques, Analytical; Chondroitin; Collagen; Glycosaminoglycans; Granuloma; Hexosamines; Histocytochemistry; Hyaluronic Acid; Hypersensitivity; Inflammation; Proteins; Research; Sulfur Isotopes

Neuropathic pain (NP) is an abnormality resulting from lesion or damage to parts of the somatosensory nervous system. It is linked to defective quality of life and often poorly managed. Due to the limited number of approved drugs, limited efficacy and side effects associated with the approved drugs, drugs or drug combinations with great efficacy and very minimal or no side effects will be of great advantage in managing NP. This study aimed at investigating the synergistic antinociceptive effects of the combination of glucosamine sulphate (GS) (240 mg/kg) and chondroitin sulphate (CS) (900 mg/kg) in chronic constriction injury (CCI)-induced neuropathy in rats. Forty-two Wistar rats were randomly distributed into seven groups (n = 6). Sciatic nerve was ligated with four loose ligatures to induce NP. Effects of drugs were examined on stimulus and non-stimulus evoked potentials, expression of dorsal root ganglia (DRG) pain modulators and structural architecture of DRG. Oral administration of GS and CS for 21 days reduced hyperalgesia, allodynia, sciatic nerve functional aberration and DRG pain modulators. Histopathology and immunohistochemistry revealed restoration of structural integrity of DRG. Our result showed that the combination of GS and CS produced antinociceptive effects by attenuating hyperalgesia, allodynia and downregulation of NP mediators. GS and CS additionally produced synergistic analgesic effect over its individual components.

Topics: Animals; Chondroitin; Chronic Pain; Constriction; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ganglia, Spinal; Glucosamine; Inflammation; Male; Neuralgia; Rats; Rats, Wistar; Sciatic Nerve

Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Centers for Disease Control and Prevention, U.S.; Chondroitin; Cross-Sectional Studies; Dietary Supplements; Female; Glucosamine; Humans; Inflammation; Male; Middle Aged; Nutrition Surveys; United States

Glucosamine and chondroitin supplements have been shown to have anti-inflammatory properties in both in vitro studies and animal models; however, little is known about these relationships in humans. The VITamins and Lifestyle (VITAL) biomarker study evaluated the associations between use of these supplements and a panel of circulating inflammatory biomarkers.. Study participants included 217 men and women age 50-75 years living in the Seattle metropolitan area. Use of glucosamine and chondroitin supplements was ascertained by home interview/supplement inventory. Inflammation was assessed by using blood and urine collected at the time of home interview. Measures of systemic inflammation included plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, soluble TNF receptors I and II, and urinary prostaglandin E2-metabolite (PGE-M). Multivariate-adjusted linear regression was used to evaluate the associations between supplement use and biomarkers of inflammation.. High users (14 or more pills/week) of chondroitin had 36% lower hsCRP (ratio, 0.64; 95% confidence interval [CI], 0.39-1.04; p for trend=.03) and 27% lower PGE-M (ratio, 0.73; 95% CI, 0.5-0.98; p for trend=.07) than nonusers. Compared with nonusers, high users of glucosamine had 28% lower hsCRP (ratio, 0.72; 95% CI, 0.47-1.08; p for trend=.09) and 24% lower PGE-M (ratio, 0.76; 95% CI, 0.59-0.97; p for trend=0.10). Use of glucosamine and chondroitin supplements was not associated with the other markers of inflammation.. These results support prior research suggesting that use of glucosamine and chondroitin is associated with reduced hsCRP and PGE2, but further work is needed to more definitively evaluate the anti-inflammatory potential of these supplements.

Topics: Aged; Biomarkers; C-Reactive Protein; Chondroitin; Cytokines; Dietary Supplements; Female; Glucosamine; Humans; Inflammation; Male; Middle Aged

We evaluated the effects of glucosamine chondroitine sulphate (glcN-CS) on rat Achilles tendons in this experimental animal study.. Thirty Wistar albino type rats weighing 300-350 g were randomly grouped into two. Group A: Achilles tendons were tenotomized, repaired and, glcN-CS given orally. Group B: Achilles tendons were tenotomized and repaired. All the rats were fed with pellet chow. Five rats in each group were sacrificed at 4, 8, and 12 weeks interval. Tensile strength of three tendon specimen from each group were tested biomechanically and two specimen were analysed histopathologically via immunohistochemical staining and hematoxylin and eosin staining. Contralateral side Achilles tendons were also grouped and analyzed as controls (group C and D).. Histological results showed well organized collagen formation and less inflammation in group A. Biomechanical testing showed higher tendon strength in group A at eight weeks which is not statisticaly significant (55.3±4.84N, p=0.078). Rats which were were given glcN-CS had greater tendon strength which is statisticaly significant (50.01±5.62, p=0.014).. Glucoseamine chondroitine sulphate improved results of Achilles tendon healing in rats. This result might be due to decreased inflammation and stimulation of collagen synthesis. Although glcN-CS is recommended only in osteoarthritic patients to relieve symptoms and signs it can also be prefered in treatment of soft tissue injuries formed during sports activities.

Topics: Achilles Tendon; Animals; Biomechanical Phenomena; Chondroitin; Inflammation; Random Allocation; Rats; Rats, Wistar; Tendon Injuries; Tensile Strength; Wound Healing

Topics: Animals; Burns; Chondroitin; Chondroitin Sulfates; Collagen; Female; Inflammation; Injections, Intradermal; Male; Rats; Rats, Inbred Strains; Time Factors; Wound Healing

Topics: Biopsy; Chondroitin; Edema; Glycosaminoglycans; Humans; Hyaluronic Acid; Inflammation; Prostaglandins; Skin; Skin Diseases; Sulfates

Topics: Animals; Anti-Inflammatory Agents; Blood Platelets; Blood Proteins; Blood Sedimentation; Carrageenan; Chondroitin; Collagen; Dogs; Edema; Enzymes; Erythrocytes; Hyaluronic Acid; In Vitro Techniques; Indomethacin; Inflammation; L-Lactate Dehydrogenase; Prostaglandins

Topics: Animals; Chondroitin; Glycosaminoglycans; Hindlimb; Hyaluronic Acid; Inflammation; Rats; Sodium Salicylate; Trypsin

Topics: Chondroitin; Coloring Agents; Cushing Syndrome; Dermatology; Erythema Multiforme; Heparin; Hexosamines; Histocytochemistry; Humans; Hyaluronic Acid; Hydroxyproline; Inflammation; Mast Cells; Myxedema; Pigmentation Disorders; Scleroderma, Systemic; Skin Neoplasms; Staining and Labeling; Urticaria; Wound Healing

Topics: Albumins; Arteriosclerosis; Carbohydrate Metabolism; Chondroitin; Connective Tissue; Edema; Guinea Pigs; Hepatitis; Hypoxia; Inflammation; Lipopolysaccharides; Pharmacology; Rabbits; Radiation Effects; Rats; Research; Shwartzman Phenomenon; Silicosis; Sulfates; Sulfur Isotopes; Sulfuric Acids

Topics: Antirheumatic Agents; Biochemical Phenomena; Chondroitin; Chondroitin Sulfates; Glycosaminoglycans; Humans; Inflammation; Phenylbutazone; Prednisone; Rheumatic Diseases