chondroitin and Hypertension

Topics: Arthritis; Chondroitin; Common Cold; Consumer Product Safety; Dietary Supplements; Evidence-Based Medicine; Fish Oils; Garlic; Glucosamine; Glycine max; Heart Diseases; Humans; Hypertension; Menopause; Neoplasms; Phytotherapy; Research Design; Tea; Zinc Compounds

Osteoarthritis (OA) is a frequently occurring, chronic condition; however, few studies describe the clinical characteristics of individuals with OA and the treatments they use to manage their symptoms. We conducted a study to characterize the OA population in the US and describe the nonsurgical management used by this population based on consumer research data collected through an online survey.. Data from the 2017 US National Health and Wellness Survey (NHWS) for adults aged ≥35 years were used to evaluate the relationship between OA and certain study participant characteristics and to identify the most commonly used treatment options. NHWS data were collected through a survey of individuals drawn from the internet panel maintained by Lightspeed Research (Bridgewater, New Jersey) and its panel partners. Weighted estimates were generated using data from the 2016 Current Population Survey (Annual Demographics File) of the US Census Bureau. Comparisons between the general and OA populations were made based on body mass index (BMI), exercise frequency, and comorbid diagnoses of hypertension or diabetes. Among the OA population, the use of dietary supplements, prescription or over-the-counter (OTC) treatments with chondroitin with or without glucosamine (Ch ± Gl), prescription treatment by time since OA diagnosis, and utilization of a physical therapist were also recorded.. The prevalence of OA in the overall population was 17.6 % and was higher for individuals with a BMI ≥ 25 (21.9 %), patients diagnosed with hypertension or diabetes (36.2 %), and those who did not exercise regularly (19.0 %). Adults without OA were more likely to exercise regularly (12 days per month or more) than adults diagnosed with OA. Ch ± Gl (6.0 %) was the most commonly used OTC dietary supplement in the OA population, followed by omega-3 fatty acids (2.8 %), vitamin D (1.9 %), calcium (1.1 %), and multivitamins (0.7 %). Individuals using Ch ± Gl were more likely to use OTC only products (75.4 % vs 37.3 %) or prescription medications, namely non-steroidal anti-inflammatory drugs (NSAIDs) and/or opioids, and OTC products (24.6 % vs 13.0 %) compared with individuals not using Ch ± Gl, while individuals not using Ch ± Gl were more likely to be untreated (30.3 % vs 0) or to use prescription medications only (19.4 % vs 0). Nearly 32 % of individuals with OA reported using prescription treatments, and the likelihood of using a prescription treatment increased with number of years since OA diagnosis (<3 years: 27.5 %; ≥21 years: 32.5 %). The pharmaceutical products used by this population primarily consisted of nonsteroidal anti-inflammatory drugs, acetaminophen and opioids. Approximately 13 % of patients with OA had visited a physical therapist in the past 6 months.. The prevalence of OA was higher in those with a high BMI, and comorbid diabetes or hypertension. Individuals with OA using Ch ± Gl primarily reported use of OTC products only or used them in combination with prescription products. The likelihood of using prescription products increased with the length of OA history. These data provide valuable new information about demographics, clinical characteristics, and commonly used prescription and OTC treatments and dietary supplements in the OA population.

Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Chondroitin; Comorbidity; Diabetes Mellitus; Dietary Supplements; Drug Utilization; Exercise; Female; Glucosamine; Health Surveys; Humans; Hypertension; Male; Middle Aged; Nonprescription Drugs; Osteoarthritis; United States; Vitamins

Topics: Chondroitin; Glucosamine; Hypertension; Nonprescription Drugs; Osteoarthritis; Pain; Proteinuria

Topics: Adolescent; Adult; Age Factors; Aged; Aorta; Arteriosclerosis; Autopsy; Child; Child, Preschool; Chondroitin; Female; Glycosaminoglycans; Humans; Hyaluronic Acid; Hypertension; Infant; Male; Middle Aged; Sex Factors

Topics: Adolescent; Aorta; Autopsy; Blood Vessels; Cerebral Hemorrhage; Chondroitin; Cytogenetics; Female; Glycosaminoglycans; Histocytochemistry; Humans; Hyaluronic Acid; Hypertension; Karyotyping; Leukocytes; Sex Chromosomes; Sulfates; Sulfur Radioisotopes; Turner Syndrome; Uronic Acids

Topics: Adult; Aged; Aging; Cerebrovascular Disorders; Chondroitin; Diabetes Mellitus; Diabetic Nephropathies; Electrophoresis; Female; Glycosaminoglycans; Heart Diseases; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Hypertension; Liver Cirrhosis; Male; Middle Aged; Uronic Acids

Topics: Animals; Arteries; Carbon Isotopes; Chondroitin; Disease Models, Animal; Glycosaminoglycans; Heparin; Hypertension; Lipid Metabolism; Radioactivity; Rats

Topics: Animals; Aorta; Blood Proteins; Carotid Arteries; Chondroitin; Coronary Vessels; Glycosaminoglycans; Hexoses; Histocytochemistry; Hypertension; Hypoxia, Brain; Male; Neuraminic Acids; Rabbits

Topics: Aging; Aorta; Arteries; Arteriosclerosis; Blood Pressure; Chondroitin; Electrophoresis; Glycosaminoglycans; Heparin; Histocytochemistry; Humans; Hyaluronic Acid; Hypertension; Hypertension, Pulmonary; Iliac Artery; Pulmonary Artery