chondroitin and Diabetes-Mellitus

The paper is a clinical experimental work, studying the heparinoid effect upon blood sugar level, blood lipid fractions, endogenic heparin and lipo-brigther-becoming activity in diabetics. Heparinoids are applied in acute experiment. A total of 37 subjects were examined--22 diabetics with adult type of diabetes, 10 clinically healthy subjects and 5 diabetics examined only with 500 ml physiologic salt solution. The same patients were examined with heparin as well for a comparison. Blood sugar, NEFA, lipolyzing activity, total lipids, total cholesterol, beta-lipoproteins, total phospholipids, triglycerides and endogenic heparin were determined prior to and post infusion introduction of heparinoids. The results reveal that heparinoids have two basic biochemical effects decrease blood sugar lever in diabetics and change the blood lipid fraction level. They depend on the structural peculiarities of the preparations. Heparinoids stimulate heparin activity as well, through which they realize their biochemical effect to a certain extent. The decreasing effect on blood sugar level of heparinoids is stronger as compared with heparin.

Topics: Adolescent; Adult; Aged; Blood Glucose; Chondroitin; Clinical Trials as Topic; Diabetes Mellitus; Drug Combinations; Drug Evaluation; Female; Heparin; Heparinoids; Humans; Lipids; Male; Middle Aged; Pentosan Sulfuric Polyester; Placebos

Osteoarthritis (OA) is a frequently occurring, chronic condition; however, few studies describe the clinical characteristics of individuals with OA and the treatments they use to manage their symptoms. We conducted a study to characterize the OA population in the US and describe the nonsurgical management used by this population based on consumer research data collected through an online survey.. Data from the 2017 US National Health and Wellness Survey (NHWS) for adults aged ≥35 years were used to evaluate the relationship between OA and certain study participant characteristics and to identify the most commonly used treatment options. NHWS data were collected through a survey of individuals drawn from the internet panel maintained by Lightspeed Research (Bridgewater, New Jersey) and its panel partners. Weighted estimates were generated using data from the 2016 Current Population Survey (Annual Demographics File) of the US Census Bureau. Comparisons between the general and OA populations were made based on body mass index (BMI), exercise frequency, and comorbid diagnoses of hypertension or diabetes. Among the OA population, the use of dietary supplements, prescription or over-the-counter (OTC) treatments with chondroitin with or without glucosamine (Ch ± Gl), prescription treatment by time since OA diagnosis, and utilization of a physical therapist were also recorded.. The prevalence of OA in the overall population was 17.6 % and was higher for individuals with a BMI ≥ 25 (21.9 %), patients diagnosed with hypertension or diabetes (36.2 %), and those who did not exercise regularly (19.0 %). Adults without OA were more likely to exercise regularly (12 days per month or more) than adults diagnosed with OA. Ch ± Gl (6.0 %) was the most commonly used OTC dietary supplement in the OA population, followed by omega-3 fatty acids (2.8 %), vitamin D (1.9 %), calcium (1.1 %), and multivitamins (0.7 %). Individuals using Ch ± Gl were more likely to use OTC only products (75.4 % vs 37.3 %) or prescription medications, namely non-steroidal anti-inflammatory drugs (NSAIDs) and/or opioids, and OTC products (24.6 % vs 13.0 %) compared with individuals not using Ch ± Gl, while individuals not using Ch ± Gl were more likely to be untreated (30.3 % vs 0) or to use prescription medications only (19.4 % vs 0). Nearly 32 % of individuals with OA reported using prescription treatments, and the likelihood of using a prescription treatment increased with number of years since OA diagnosis (<3 years: 27.5 %; ≥21 years: 32.5 %). The pharmaceutical products used by this population primarily consisted of nonsteroidal anti-inflammatory drugs, acetaminophen and opioids. Approximately 13 % of patients with OA had visited a physical therapist in the past 6 months.. The prevalence of OA was higher in those with a high BMI, and comorbid diabetes or hypertension. Individuals with OA using Ch ± Gl primarily reported use of OTC products only or used them in combination with prescription products. The likelihood of using prescription products increased with the length of OA history. These data provide valuable new information about demographics, clinical characteristics, and commonly used prescription and OTC treatments and dietary supplements in the OA population.

Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Chondroitin; Comorbidity; Diabetes Mellitus; Dietary Supplements; Drug Utilization; Exercise; Female; Glucosamine; Health Surveys; Humans; Hypertension; Male; Middle Aged; Nonprescription Drugs; Osteoarthritis; United States; Vitamins

Topics: Adult; Aged; Aging; Cerebrovascular Disorders; Chondroitin; Diabetes Mellitus; Diabetic Nephropathies; Electrophoresis; Female; Glycosaminoglycans; Heart Diseases; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Hypertension; Liver Cirrhosis; Male; Middle Aged; Uronic Acids

Topics: Adenine Nucleotides; Adenosine Monophosphate; Animals; Chondroitin; Chromatography, Paper; Depression, Chemical; Diabetes Mellitus; Enzymes; Liver; Male; Metabolism; Pancreas; Pancreatectomy; Phosphoric Acids; Rats; Solubility; Stimulation, Chemical; Sulfates; Sulfur Isotopes; Sulfuric Acids

Topics: Animals; Chondroitin; Diabetes Mellitus

Topics: Adolescent; Adult; Autopsy; Chondroitin; Chromatography, Gas; Diabetes Mellitus; Diabetic Nephropathies; Electrophoresis; Female; Glycosaminoglycans; Humans; Hyaluronic Acid; Kidney; Kidney Diseases; Male; Methods; Middle Aged; Organ Size; Sulfuric Acids

Topics: Animals; Aorta; Arteriosclerosis; Blood Glucose; Chondroitin; Diabetes Complications; Diabetes Mellitus; Dialysis; Glycosaminoglycans; Heparin; Hyaluronic Acid; Insulin; Male; Methods; Pancreatectomy; Rats; Skin; Sulfates; Sulfur Isotopes; Uronic Acids

Topics: Animals; Chondroitin; Diabetes Mellitus; Kinetics; Liver; Male; Pancreas; Pancreatectomy; Rats; Sulfatases; Sulfates; Sulfur Isotopes

Topics: Animals; Arabinose; Arteriosclerosis; Autoradiography; Chondroitin; Chromatography, Gas; Chromatography, Thin Layer; Diabetes Mellitus; Diabetic Angiopathies; Dietary Carbohydrates; Dogs; Evoked Potentials; Fructose; Galactose; Glucose; Glycosuria; Humans; Intestinal Absorption; Jejunum; Male; Mannose; Polysaccharides; Rats; Sucrose; Time Factors; Vascular Diseases; Xylitol

Topics: Aged; Aorta; Arteriosclerosis; Chondroitin; Diabetes Complications; Diabetes Mellitus; Female; Glycosaminoglycans; Heparin; Humans; Hyaluronic Acid; Male; Middle Aged

Topics: Cartilage; Chondroitin; Diabetes Mellitus; Female; Growth Hormone; Human Growth Hormone; Humans; Metabolism; Pre-Eclampsia; Pregnancy; Pregnancy in Diabetics; Rats; Research; Sulfates; Sulfur Isotopes

Topics: Chondroitin; Chondroitin Sulfates; Diabetes Complications; Diabetes Mellitus; Disease; Humans; Retina; Retinal Diseases