chondroitin and Chronic-Disease

Osteoarthritis, characterised by joint pain and stiffness, is a common and significant chronic disease, reducing mobility and causing considerable impact on quality of life. Multiple evidence based management options are available.. The aim of this article is to summarise the main management options suggested in The Royal Australian College of General Practitioners Guideline for the nonsurgical management of hip and knee osteoarthritis and to also highlight those that are not recommended.. Following diagnosis based primarily on history and examination, management focuses on optimising quality of life by providing self management advice combined with appropriate pharmacological and nonpharmacological strategies, aiming to reduce acute exacerbations, prevent complications and delay progression.

Topics: Adrenal Cortex Hormones; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin; Chronic Disease; Disease Progression; Glucosamine; Humans; Injections, Intra-Articular; Osteoarthritis; Practice Guidelines as Topic; Practice Patterns, Physicians'; Primary Health Care

Derangements in iron metabolism following liver damage were studied with special reference to iron deposit in relation to reticuloendothelial functions. In clinical studies, the metabolic fate of chondroitin sulfuric 59Fe, given intravenously, was examined in patients with chronic hepatitis or liver cirrhosis, diagnosed by liver biopsy. In experimental studies, liver damage was induced in rats by carbon tetrachloride (CCl4) injection and the labeled iron was similarly administered. 1) In patients with chronic hepatitis or liver cirrhosis, a reduction in uptake and utilization rates of the labeled iron was observed. 2) In rats with CCl4-induced liver damage, these parameters of the reticuloendothelial function were more reduced in parallel with the extent of hepatic fibrosis. 3) Similar conclusion was obtained from the analysis of iron distribution among tissues and of iron incorporation into several fractions of the liver: that is the uptake into non-hemin iron was less as the fibrosis advanced. In addition, more iron was incorporated into hemosiderin fraction and less into ferritin fraction. The findings may suggest a derangement in apoferritin synthesis as well as in release mechanism of deposit iron. 4) It is suggested that derangements in iron metabolism following liver damage are mainly due to reduction of the reticuloendothelial functions, but are partly due to changes in hematopoiesis and protein metabolism.

Topics: Animals; Carbon Tetrachloride Poisoning; Chondroitin; Chondroitin Sulfates; Chronic Disease; Hepatitis; Humans; Iron; Liver Cirrhosis; Male; Mononuclear Phagocyte System; Rats

Topics: Adolescent; Adult; Chondroitin; Chronic Disease; Female; Glycosaminoglycans; Histocytochemistry; Humans; Hyaluronoglucosaminidase; Injections; Male; Muramidase; Oleandomycin; Radiography; Sinusitis; Tetracycline

Topics: Adrenal Glands; Animals; Brain Chemistry; Cattle; Chondroitin; Chronic Disease; DNA; Dura Mater; Glycosaminoglycans; Growth; Hydroxyproline; Intracranial Pressure; Kidney; Liver; Male; Nitrogen; Nutrition Disorders; Pituitary Gland; RNA; Sulfates; Vitamin A

Topics: Adolescent; Carbohydrate Metabolism; Child; Chondroitin; Chronic Disease; Connective Tissue; Female; Glycoproteins; Glycosaminoglycans; Hexosamines; Humans; Hyaluronic Acid; Male; Pneumonia

Topics: Adult; Age Factors; Aged; Bronchi; Bronchiectasis; Cartilage; Chondroitin; Chronic Disease; Female; Glycosaminoglycans; Humans; Male; Middle Aged; Pulmonary Emphysema; Respiratory Tract Diseases; Ribs; Trachea

Topics: Alcohol Oxidoreductases; Animals; Antibody Formation; Antineoplastic Agents; Arthritis, Rheumatoid; Chondroitin; Chronic Disease; Collagen; Connective Tissue; Hepatitis; Humans; Immunosuppressive Agents; Rabbits

Topics: Chondroitin; Chronic Disease; Glycosaminoglycans; Humans; Paranasal Sinuses; Sinusitis