chondroitin and Cataract

Topics: Amino Acids; Animals; Biological Transport, Active; Cataract; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chemistry Techniques, Analytical; Cholinesterase Inhibitors; Chondroitin; Collagen; Cornea; Crystallins; Epithelium; Galactose; Galactosemias; Glucose; Humans; Lens, Crystalline; Naphthoquinones; Ocular Physiological Phenomena; Protein Biosynthesis; Rabbits; Sulfhydryl Compounds; Wound Healing

To evaluate the effect of Viscoat (sodium chondroitin sulfate 4%-sodium hyaluronate 3%) and DuoVisc (Viscoat and Provisc [sodium hyaluronate 1%]) on postoperative intraocular pressure (IOP) after bilateral small-incision cataract surgery.. Department of Ophthalmology, University of Vienna, Vienna, Austria.. This prospective randomized study comprised 60 eyes of 30 consecutive patients with age-related cataract in both eyes. Each patient's eyes were randomly assigned to receive Viscoat or DuoVisc during cataract surgery. DuoVisc is a packet containing 2 ophthalmic viscosurgical devices (OVDs): the dispersive Viscoat, which was used for intraocular lens (IOL) implantation. In the Viscoat group, the Viscoat was used during the entire surgery. The intraocular pressure (IOP) was measured preoperatively as well as 1, 6, and 20 to 24 hours postoperatively.. One and 6 hours postoperatively, the mean IOP was significantly higher in the Viscoat group than in the DuoVisc group (25.8 mm Hg and 20.5 mm Hg, respectively, at 1 hour and 24.7 mm Hg and 21.1 mm Hg, respectively, at 6 hours) (P<.05). At 20 to 24 hours, the mean IOP was not statistically significantly different between the 2 groups. Intraocular pressure spikes to 30 mm Hg or higher occurred in 4 eyes in the DuoVisc group and 11 eyes in the Viscoat group (P<.05).. Viscoat caused significantly higher IOP increases and significantly more IOP spikes than DuoVisc in the early postoperative period. Therefore, if Viscoat is used during cataract surgery, an additional cohesive OVD should be used for IOL implantation.

Topics: Aged; Aged, 80 and over; Capsulorhexis; Cataract; Chondroitin; Chondroitin Sulfates; Drug Combinations; Female; Humans; Hyaluronic Acid; Intraocular Pressure; Lens Implantation, Intraocular; Male; Microsurgery; Middle Aged; Phacoemulsification; Postoperative Period; Prospective Studies; Tonometry, Ocular

To introduce a case of iridoschisis patient who underwent cataract surgery successfully without pupil device.. A 64-year-old female who showed iridoschisis of her both eyes underwent cataract operation at her right eye without a pupillary device. The preoperative and postoperative ophthalmologic examinations including visual acuity, intraocular pressure, reaction of anterior chamber, and degree of damage on iris was evaluated respectively.. Cataract surgery was performed under topical anesthesia through a clear corneal incision. Iris fibrils were held in place by ophthalmic viscosurgical device (OVD, sodium hyaluronate 3%-sodium chondroitin sulfate 4%, Viscoat) that was injected into the anterior chamber. A small capsulorrhexis was made and the nucleus was delivered with low-power phacoemulsification, most of which was performed under the anterior capsule. The iris came into contact with the OVDs only and received no mechanical trauma. There were no intraoperative complications such as tear of the iris, hyphema, loss of mydriasis, or rupture of the posterior lens capsule. The edema of corneal stroma and inflammation of anterior chamber was shown at immediate-postoperative period, but completely subsided 2 weeks later. The visual acuity showed improvement from 20/400 to 20/30.. In iridoschisis patients, there is a risk of aspiration of iris fibers during cataract surgery. With adequate use of OVD and careful modulation of surgical devices, cataract surgery was successfully performed without using extra pupil-supporting device.

Topics: Anesthesia, Local; Cataract; Chondroitin; Chondroitin Sulfates; Drug Combinations; Female; Humans; Hyaluronic Acid; Iris Diseases; Lens Implantation, Intraocular; Middle Aged; Phacoemulsification; Visual Acuity

To evaluate whether the soft-shell technique using Viscoat (sodium hyaluronate 3%-chondroitin sulfate 4%) and Hyal-2000 (sodium hyaluronate 1%) reduces corneal endothelial cell damage during cataract surgery.. Department of Ophthalmology, Kangnam St. Mary's Hospital, Seoul, Korea.. The nuclear opacity in 252 eyes of 230 cataract patients was classified as grade 1, 2, 3, or > or =4 using the Lens Opacities Classification System III. In each classification, the patients were divided into 4 groups before phacoemulsification based on the type of ophthalmic viscosurgical device (OVD) used during surgery: Viscoat and Hyal-2000 (soft-shell technique), Viscoat alone, Hyal-2000 alone, or Provisc (sodium hyaluronate 1%) alone. All patients were operated on using the same technique except for the OVD. The visual acuity, corneal endothelial cell density, corneal thickness, and intraocular pressure (IOP) were evaluated postoperatively.. The rate of endothelial cell loss 2 months after surgery in eyes with a nuclear opacity grade of > or =4 was significantly different between the 4 OVD groups. The rate in eyes with a nuclear opacity grade of < or =3 was not significantly different between the groups. There were no statistically significant differences between the 4 groups in visual acuity, corneal thickness, or IOP throughout the follow-up period.. The soft-shell technique using Viscoat and Hyal-2000 protected corneal endothelial cells during cataract surgery in patients with a nuclear opacity grade of > or =4.

Topics: Aged; Cataract; Cell Count; Chondroitin; Chondroitin Sulfates; Drug Combinations; Drug Therapy, Combination; Endothelium, Corneal; Female; Humans; Hyaluronic Acid; Intraoperative Complications; Lens Implantation, Intraocular; Male; Middle Aged; Phacoemulsification; Prospective Studies; Treatment Outcome

Topics: Academic Dissertations as Topic; Animals; Biochemical Phenomena; Biochemistry; Cataract; Chondroitin; Colloids; Dogs; Eye Injuries; Fundus Oculi; Gels; Heparin; Hyaluronic Acid; Injections; Ion Exchange; Ion Exchange Resins; Iron; Lens, Crystalline; Models, Biological; Photography; Polysaccharides; Rabbits; Retina; Retinal Detachment; Staining and Labeling; Sulfates; Sulfonic Acids; Tissue Adhesions; Uronic Acids; Vitreous Body