chondroitin has been researched along with Carbon-Tetrachloride-Poisoning* in 3 studies
3 other study(ies) available for chondroitin and Carbon-Tetrachloride-Poisoning
Article | Year |
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The heterogeneity of dermatan sulfate and heparan sulfate in rat liver and a shift in the glycosaminoglycan contents in carbon tetrachloride-damaged liver.
The glycosaminoglycan of rat liver can be separated into five distinct fractions; a hyaluronic acid fraction, a heparan sulfate fraction with a molar ratio of sulfate to hexosamine (S/HexN) around 0.7, a heparan sulfate fraction with a S/HexN ratio around 1.4, a dermatan sulfate fraction with a S/HexN ratio near unity, and a dermatan sulfate fraction with a S/HexN ratio around 1.3. Enzymatic analysis of the two dermatan sulfate fractions indicates that they differ significantly in that the high sulfated fraction contains relatively more N-acetylgalactosamine 4,6-bissulfate units (about 26% of the total hexosamine). In experimental injury produced by carbon tetrachloride, the low sulfated fraction increases as much as 9-fold on a dry weight basis, bearing no linear relationship to the amount of the high sulfated fraction which increases only 2-fold. A significant shift is also observed in the levels of the two heparan sulfate fractions. In this case, however, the high sulfated fraction shows a much more pronounced increase than does the low sulfated fraction. On the basis of these observations, it is suggested that for each of the dermatan sulfate and heparan sulfate classes there are at least two pools, distinguished by sulfation degree and perhaps by turnover rate and physiological function. Topics: Animals; Carbon Tetrachloride Poisoning; Chondroitin; Chondroitinases and Chondroitin Lyases; Chromatography, DEAE-Cellulose; Chromatography, Paper; Dermatan Sulfate; Electrophoresis, Cellulose Acetate; Glycosaminoglycans; Heparitin Sulfate; Liver; Male; Polysaccharides; Rats | 1976 |
[Clinical and experimental studies on the fate of chondrotin s-lfuric iron during developing hepatic fibrosis (author's transl)].
Derangements in iron metabolism following liver damage were studied with special reference to iron deposit in relation to reticuloendothelial functions. In clinical studies, the metabolic fate of chondroitin sulfuric 59Fe, given intravenously, was examined in patients with chronic hepatitis or liver cirrhosis, diagnosed by liver biopsy. In experimental studies, liver damage was induced in rats by carbon tetrachloride (CCl4) injection and the labeled iron was similarly administered. 1) In patients with chronic hepatitis or liver cirrhosis, a reduction in uptake and utilization rates of the labeled iron was observed. 2) In rats with CCl4-induced liver damage, these parameters of the reticuloendothelial function were more reduced in parallel with the extent of hepatic fibrosis. 3) Similar conclusion was obtained from the analysis of iron distribution among tissues and of iron incorporation into several fractions of the liver: that is the uptake into non-hemin iron was less as the fibrosis advanced. In addition, more iron was incorporated into hemosiderin fraction and less into ferritin fraction. The findings may suggest a derangement in apoferritin synthesis as well as in release mechanism of deposit iron. 4) It is suggested that derangements in iron metabolism following liver damage are mainly due to reduction of the reticuloendothelial functions, but are partly due to changes in hematopoiesis and protein metabolism. Topics: Animals; Carbon Tetrachloride Poisoning; Chondroitin; Chondroitin Sulfates; Chronic Disease; Hepatitis; Humans; Iron; Liver Cirrhosis; Male; Mononuclear Phagocyte System; Rats | 1974 |
The synthesis of sulphated mucopolysaccharide in mouse liver following carbon tetrachloride injury. II. Quantitation and partial characterization of extracted mucopolysaccharide.
Topics: Animals; Carbon Tetrachloride Poisoning; Chondroitin; Chromatography, Thin Layer; Glucosamine; Glycosaminoglycans; Heparin; Hexosamines; Hyaluronoglucosaminidase; Liver; Male; Mice; Sulfur Isotopes | 1969 |