chondroitin and Body-Weight

One and 3 mg/kg iron as Condrofer**, a new soluble formulation of this metal, and 1 mg/kg iron as Proteoferrina*** or ferritin were given orally for 4 weeks to male rats in which severe experimental anaemia had previously been induced (by iron-deficient diet and repeated bleedings). Haematological (erythrocyte count, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, reticulocytes and leukocytes) and blood chemistry (sodium, potassium, iron and total protein) parameters were checked weekly and at the end of the drug administration period. Clinical and behavioral signs, body weight, food intake and necroscopic observations were also recorded. Condrofer time- and dose-dependently improved the general blood picture, the clinical data and the autoptic findings to the point of making these animals significantly approach control rats, save for one parameter, sideremia, which after 4 weeks of treatment remained lower than normal. The most plausible explanation would seem that the severe anaemia interfered both with the physiological iron storage and with the iron-dependent mitochondrial enzymatic systems. Iron (1 mg/kg) daily as Proteoferrina or ferritin was significantly less effective than when this metal was administered as Condrofer, since all the haematological parameters and the clinical, behavioral signs and necroscopic observations were less favourable. The more complete reversal of anaemia in the rats that received Condrofer is, most probably, due to the higher bioavailability of iron administered under this formulation, as demonstrated by iron kinetics after equidoses of iron as Condrofer and Proteoferrina.

Topics: Anemia, Hypochromic; Animals; Body Weight; Chondroitin; Chondroitin Sulfates; Hematocrit; Hemoglobins; Iron; Male; Rats; Rats, Inbred Strains; Reference Values

Topics: Birth Weight; Body Height; Body Weight; Child Development; Chondroitin; Female; Gestational Age; Glycosaminoglycans; Growth Disorders; Heparin; Humans; Hyaluronic Acid; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Male; Pregnancy

Topics: Animals; Body Fluids; Body Water; Body Weight; Chondroitin; Estradiol; Hexosamines; Histological Techniques; Hyaluronic Acid; Male; Mice; Skin; Uronic Acids; Water

Topics: Animals; Body Weight; Chondroitin; Connective Tissue; Diet; Estradiol; Galactosamine; Injections, Intraperitoneal; Male; Rats; Skin; Sulfates; Time Factors

Topics: Abdomen; Age Factors; Animals; Arm; Body Weight; Chondroitin; Foot; Glycosaminoglycans; Guinea Pigs; Heparin; Humans; Hyaluronic Acid; Leg; Mice; Rats; Scalp; Skin

Topics: Analysis of Variance; Animals; Aorta; Blood Sedimentation; Body Weight; Calcinosis; Cholesterol; Chondroitin; Coronary Vessels; Ergocalciferols; Female; Flavonoids; Hematocrit; Necrosis; Nephrocalcinosis; Rats; Rutin

Topics: Aging; Animals; Body Weight; Cartilage; Chondroitin; Female; Glucosamine; Hexosamines; Male; Minerals; Polysaccharides; Sharks; Sulfates; Uronic Acids

Topics: Animals; Aorta; Arteriosclerosis; Body Weight; Chondroitin; Diet, Atherogenic; Female; Haplorhini; Histocytochemistry; Lipids; Male

Topics: Animals; Body Weight; Chick Embryo; Chondroitin; Culture Techniques; Cyanides; Lathyrism

Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Autoradiography; Blood Chemical Analysis; Body Weight; Bone and Bones; Cartilage; Cartilage, Articular; Chondroitin; Dextran Sulfate; Dextrans; Fractures, Bone; Guinea Pigs; Hemorrhage; Heparin; Osteoporosis; Pathology; Pharmacology; Rabbits; Rats; Research; Sulfur Isotopes; Toxicology; Wound Healing