chondroitin and Anemia--Hypochromic

The authors conducted a clinical investigation on sixty-nine pregnant women, anaemic and non-anaemic, the purpose being to assess the effect of 50 days treatment with four different medicinal iron preparations, namely, ferrous sulphate, iron chondroitinsulfuric acid complex, and ferritin alone or associated with folinic acid and cobamamide, on various haematological parameters (Hb, RCC, Ht, CV, Iron, and Transferrin IBC). The four products demonstrated a similar efficacy in maintaining anaemic conditions under control; moreover, the results confirmed our hypothesis of the absorption of iron ferritin. While three products were well tolerated, ferrous sulphate induced, in some cases, side-effects.

Topics: Adult; Anemia, Hypochromic; Chondroitin; Chondroitin Sulfates; Cobamides; Drug Combinations; Drug Therapy, Combination; Erythrocyte Count; Erythrocyte Indices; Female; Ferritins; Ferrous Compounds; Hematocrit; Hemoglobins; Humans; Iron; Leucovorin; Pregnancy; Pregnancy Complications, Hematologic; Random Allocation; Transferrin

Topics: Adult; Anemia, Hypochromic; Chondroitin; Female; Ferric Compounds; Humans; Iron; Pregnancy; Puerperal Disorders; Sulfonic Acids

Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Chondroitin; Chondroitin Sulfates; Female; Humans; Male; Middle Aged; Time Factors

One and 3 mg/kg iron as Condrofer**, a new soluble formulation of this metal, and 1 mg/kg iron as Proteoferrina*** or ferritin were given orally for 4 weeks to male rats in which severe experimental anaemia had previously been induced (by iron-deficient diet and repeated bleedings). Haematological (erythrocyte count, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, reticulocytes and leukocytes) and blood chemistry (sodium, potassium, iron and total protein) parameters were checked weekly and at the end of the drug administration period. Clinical and behavioral signs, body weight, food intake and necroscopic observations were also recorded. Condrofer time- and dose-dependently improved the general blood picture, the clinical data and the autoptic findings to the point of making these animals significantly approach control rats, save for one parameter, sideremia, which after 4 weeks of treatment remained lower than normal. The most plausible explanation would seem that the severe anaemia interfered both with the physiological iron storage and with the iron-dependent mitochondrial enzymatic systems. Iron (1 mg/kg) daily as Proteoferrina or ferritin was significantly less effective than when this metal was administered as Condrofer, since all the haematological parameters and the clinical, behavioral signs and necroscopic observations were less favourable. The more complete reversal of anaemia in the rats that received Condrofer is, most probably, due to the higher bioavailability of iron administered under this formulation, as demonstrated by iron kinetics after equidoses of iron as Condrofer and Proteoferrina.

Topics: Anemia, Hypochromic; Animals; Body Weight; Chondroitin; Chondroitin Sulfates; Hematocrit; Hemoglobins; Iron; Male; Rats; Rats, Inbred Strains; Reference Values

Topics: Administration, Oral; Adult; Aged; Anemia; Anemia, Hypochromic; Chondroitin; Chondroitin Sulfates; Female; Ferritins; Humans; Male; Middle Aged; Renal Dialysis

Topics: Adult; Aged; Anemia, Hypochromic; Chondroitin; Chondroitin Sulfates; Erythrocytes; Female; Ferritins; Hematinics; Humans; Iron; Male; Middle Aged; Renal Dialysis

Topics: Anemia, Hypochromic; Animals; Aorta; Calcium; Chondroitin; Diet Therapy; Glucuronates; Glycosaminoglycans; Iron; Male; Rats; Stimulation, Chemical; Sulfates; Vitamins