Page last updated: 2024-10-16

choline and Thrombosis

choline has been researched along with Thrombosis in 20 studies

Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.

Research Excerpts

ExcerptRelevanceReference
"Gut microbes influence cardiovascular disease and thrombosis risks through the production of trimethylamine N-oxide (TMAO)."5.27Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential. ( DiDonato, JA; Fischbach, MA; Guo, CJ; Haag, B; Hazen, SL; Jia, X; Kirsop, J; Lang, JM; Lusis, AJ; Rey, FE; Romano, KA; Skye, SM; Tang, WHW; Wang, Z; Zhu, W, 2018)
"Endothelial TF contributes to TMAO-related arterial thrombosis potential, and can be specifically blocked by targeted non-lethal inhibition of gut microbial choline TMA-lyase."4.12Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis. ( Buffa, JA; DiDonato, JA; Friebel, J; Haghikia, A; Hazen, SL; Kirchhofer, D; Landmesser, U; Li, L; Li, XS; Lüscher, TF; Mach, F; Matter, CM; Räber, L; Rauch, U; Sangwan, N; Tang, WHW; Tizian, C; Wang, Z; Witkowski, M, 2022)
" Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo."3.88Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. ( Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y, 2018)
"Phenylacetylglutamine, for example, was recently shown to promote adverse cardiovascular phenotypes in the host via interaction with multiple ARs (adrenergic receptors)-a class of key receptors that regulate cardiovascular homeostasis."2.66Gut Microbiota and Cardiovascular Disease. ( Hazen, SL; Weeks, TL; Witkowski, M, 2020)
"18 F-choline PET/CT was performed for initial staging and displayed several intense foci uptake of sternum and thoracic vertebrae, suggestive of bone metastasis."1.91A False-Positive Bone Oligometastatic Prostate Cancer in 18 F-Choline PET/CT : Be Aware of Chronic Vascular Pitfalls. ( Kryza, D; Larrouquere, L; Mognetti, T; Moreau, A; Pretet, V, 2023)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (40.00)24.3611
2020's4 (20.00)2.80

Authors

AuthorsStudies
Tu, R1
Xia, J1
Pretet, V1
Moreau, A1
Larrouquere, L1
Mognetti, T1
Kryza, D1
Witkowski, M3
Weeks, TL1
Hazen, SL8
Friebel, J1
Buffa, JA4
Li, XS2
Wang, Z7
Sangwan, N1
Li, L4
DiDonato, JA5
Tizian, C1
Haghikia, A1
Kirchhofer, D1
Mach, F1
Räber, L1
Matter, CM1
Tang, WHW5
Landmesser, U1
Lüscher, TF2
Rauch, U1
Zhu, W5
Marosfoi, M1
Clarencon, F1
Langan, ET1
King, RM1
Brooks, OW1
Tamura, T1
Wainwright, JM1
Gounis, MJ1
Vedantham, S1
Puri, AS1
Cajka, T1
Nemet, I1
Hurd, AG2
Gu, X2
Skye, SM3
Roberts, AB2
Wu, Y2
Shahen, CJ1
Wagner, MA1
Hartiala, JA1
Kerby, RL1
Romano, KA2
Han, Y1
Obeid, S1
Allayee, H2
Rey, FE2
Fiehn, O1
Gupta, N2
Cody, DB1
Levison, BS1
Barrington, WT1
Russell, MW1
Reed, JM1
Duzan, A1
Lang, JM2
Fu, X2
Myers, AJ1
Rachakonda, S1
Brown, JM3
Gogonea, V1
Lusis, AJ4
Garcia-Garcia, JC1
Guo, CJ1
Jia, X2
Kirsop, J1
Haag, B1
Fischbach, MA1
Shih, DM1
Schugar, RC1
Meng, Y1
Miikeda, A1
Zieger, M1
Lee, R1
Graham, M1
Cantor, RM1
Mueller, C1
Gregory, JC1
Org, E1
Mehrabian, M1
Sartor, RB1
McIntyre, TM1
Silverstein, RL1
Tilg, H1
RENAUD, S2
ALLARD, C1
MORELLI, AC1
Durrani, AA1
Hayward, JA1
Chapman, D1
Perry, TL1
Hansen, S1
Love, DL1
Crawford, LE1
Tischler, B1
Vittori, C1
Borri, P1
Bianchi, V1
Kuznik, BI1
Mishchenko, VP1
Thomas, HM1
Williams, WL1
Clower, BR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.[NCT05795946]45 participants (Anticipated)Interventional2023-04-15Recruiting
"Plant-Based Meat vs Animal Red Meat: a Randomized Cross-over Trial"[NCT04510324]41 participants (Actual)Interventional2020-11-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for choline and Thrombosis

ArticleYear
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO.
    CNS & neurological disorders drug targets, 2024, Volume: 23, Issue:1

    Topics: Choline; Cognitive Dysfunction; Gastrointestinal Microbiome; Humans; Inflammation; Stroke; Thrombosi

2024
Gut Microbiota and Cardiovascular Disease.
    Circulation research, 2020, 07-31, Volume: 127, Issue:4

    Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cardiovascular Diseases; Carnitine; Choline; Disease

2020
[Role of the heart and vessels in regulating blood coagulation and fibrinolysis].
    Kardiologiia, 1973, Volume: 13, Issue:4

    Topics: Animals; Antifibrinolytic Agents; Blood Coagulation; Blood Platelets; Blood Pressure; Blood Vessels;

1973

Trials

2 trials available for choline and Thrombosis

ArticleYear
Gut Microbe-Generated Trimethylamine
    Circulation, 2017, 04-25, Volume: 135, Issue:17

    Topics: Adult; Aspirin; Choline; Dietary Fats; Female; Gastrointestinal Microbiome; Humans; Male; Methylamin

2017
Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential.
    Circulation research, 2018, 10-26, Volume: 123, Issue:10

    Topics: Adult; Animals; Bacterial Proteins; Choline; Clostridium; Fecal Microbiota Transplantation; Female;

2018

Other Studies

15 other studies available for choline and Thrombosis

ArticleYear
A False-Positive Bone Oligometastatic Prostate Cancer in 18 F-Choline PET/CT : Be Aware of Chronic Vascular Pitfalls.
    Clinical nuclear medicine, 2023, Dec-01, Volume: 48, Issue:12

    Topics: Aged; Choline; Humans; Male; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms;

2023
Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis.
    Cardiovascular research, 2022, 07-27, Volume: 118, Issue:10

    Topics: Animals; Choline; Endothelial Cells; Humans; Lyases; Methylamines; Mice; Thromboplastin; Thrombosis

2022
Acute thrombus formation on phosphorilcholine surface modified flow diverters.
    Journal of neurointerventional surgery, 2018, Volume: 10, Issue:4

    Topics: Angioplasty; Animals; Choline; Female; Intracranial Aneurysm; Pancreatic Elastase; Phosphorus; Rabbi

2018
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
    JCI insight, 2018, 03-22, Volume: 3, Issue:6

    Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Mo

2018
Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.
    Nature medicine, 2018, Volume: 24, Issue:9

    Topics: Animals; Bacteria; Choline; Diet; Gastrointestinal Microbiome; Hexanols; Mice, Inbred C57BL; Oxidore

2018
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
    Arteriosclerosis, thrombosis, and vascular biology, 2019, Volume: 39, Issue:6

    Topics: Animals; Atherosclerosis; Choline; Disease Models, Animal; Lipid Metabolism; Methylamines; Mice; Mic

2019
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
    Cell, 2016, Mar-24, Volume: 165, Issue:1

    Topics: Animals; Blood Platelets; Calcium; Carotid Artery Injuries; Cecum; Chlorides; Choline; Diet; Female;

2016
A Gut Feeling about Thrombosis.
    The New England journal of medicine, 2016, Jun-23, Volume: 374, Issue:25

    Topics: Animals; Choline; Gastrointestinal Microbiome; Humans; Methylamines; Mice; Plasmalogens; Risk Factor

2016
DIETARY FATS, VITAMINS AND BILE ACIDS IN THE PRODUCTION OF THROMBOSIS AND HYPERLIPEMIA IN RATS.
    Revue canadienne de biologie, 1963, Volume: 22

    Topics: Bile Acids and Salts; Blood Chemical Analysis; Butter; Cholesterol; Choline; Coronary Disease; Dieta

1963
[ELEVATION OF THE DEPRESSED THROMBOLYTIC ACTIVITY, IN ARTERIOSCLEROTICS SUBJECTED TO PROLONGED ORAL ANTICOAGULANT THERAPY, USING A DERIVATIVE OF NICOTINIC ACID].
    La Semana medica, 1963, Dec-02, Volume: 123

    Topics: Aminocaproates; Aminocaproic Acid; Anticoagulants; Arteriosclerosis; Blood Coagulation Tests; Cholin

1963
Biomembranes as models for polymer surfaces. II. The syntheses of reactive species for covalent coupling of phosphorylcholine to polymer surfaces.
    Biomaterials, 1986, Volume: 7, Issue:2

    Topics: Biocompatible Materials; Blood Cells; Cell Membrane; Choline; Humans; Membranes, Artificial; Phospho

1986
Treatment of homocystinuria with a low-methionine diet, supplemental cystine, and a methyl donor.
    Lancet (London, England), 1968, Aug-31, Volume: 2, Issue:7566

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Child, Preschool; Choline; Cys

1968
[On the comparative results of the use of Clarisco in peripheral vascular diseases].
    Minerva medica, 1970, Dec-05, Issue:97 Suppl

    Topics: Aged; Arteriosclerosis Obliterans; Choline; Coronary Disease; Folic Acid; Gangrene; Heparin; Humans;

1970
Cardiac lesions in C mice. Result of choline-deficient and choline-supplemented diets.
    Archives of pathology, 1968, Volume: 85, Issue:5

    Topics: Animals; Calcinosis; Choline; Choline Deficiency; Coronary Vessels; Fibroblasts; Heart Atria; Heart

1968
Prevention by methionine feeding of atherosclerosis and thrombosis in hyperlipemic rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1966, Volume: 121, Issue:2

    Topics: Animals; Arteriosclerosis; Choline; Cystine; Diet; Hyperlipidemias; Methionine; Rats; Thrombosis

1966