choline has been researched along with Stroke in 34 studies
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with elevated levels of choline and betaine had a lower risk of depression after acute ischemic stroke, suggesting the protective significance of choline pathway nutrients for PSD." | 9.51 | Circulating choline pathway nutrients and depression after ischemic stroke. ( Che, B; Du, J; Guo, Y; Ju, Z; Miao, M; Xu, T; Zhang, J; Zhang, Y; Zhong, C; Zhong, X, 2022) |
| "Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment." | 9.41 | Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021) |
| "Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment." | 8.31 | Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring. ( Hurley, L; Ille, S; Jadavji, NM; Jauhal, J; Malysheva, OV; Pull, K, 2023) |
| " We aimed to evaluate whether residual risk of recurrent stroke of TMAO and its precursor choline remain among patients who received dual-antiplatelet therapy and intensive lipid-lowering therapy and with a low inflammation level (high-sensitivity C-reactive protein <2 mg/L on admission)." | 8.12 | Residual Risk of Trimethylamine-N-Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy. ( Cheng, A; Jiang, X; Jin, A; Li, H; Li, K; Lin, J; Meng, X; Wang, Y; Xu, J; Xue, J; Zhao, M; Zheng, L, 2022) |
| "We aimed to prospectively investigate the relationships of circulating choline and betaine with cardiovascular events and recurrent stroke in patients with ischemic stroke." | 8.02 | Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke. ( Bu, X; Che, B; Du, J; He, J; Ju, Z; Miao, M; Peng, H; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2021) |
| "Among our African-American participants, higher dietary choline intake was associated with a lower risk of incident ischemic stroke, and thus putative dietary benefits." | 7.88 | Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. ( Bidulescu, A; Dibaba, DT; Millard, HR; Musani, SK; Talegawkar, SA; Taylor, HA; Tucker, KL, 2018) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 7.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (intravenous administration) for stroke treatment in Europe and Japan, while USA phase III stroke clinical trials (oral administration) were disappointing." | 7.73 | CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. ( Adibhatla, RM; Hatcher, JF; Tureyen, K, 2005) |
| "Patients with elevated levels of choline and betaine had a lower risk of depression after acute ischemic stroke, suggesting the protective significance of choline pathway nutrients for PSD." | 5.51 | Circulating choline pathway nutrients and depression after ischemic stroke. ( Che, B; Du, J; Guo, Y; Ju, Z; Miao, M; Xu, T; Zhang, J; Zhang, Y; Zhong, C; Zhong, X, 2022) |
| "Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment." | 5.41 | Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021) |
| "Lactate/choline ratio measured in the acute infarct core by 1H MRS improves the prediction of stroke outcome and provides prognostic information complementary to DWI." | 5.09 | Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome. ( Barber, PA; Darby, DG; Davis, SM; Desmond, PM; Gerraty, RP; Li, T; Parsons, MW; Tress, BM; Yang, Q, 2000) |
| "We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy." | 5.09 | Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001) |
| "Increased TMAO was associated with higher stroke risk in the community-based population, whereas the TMAO precursors carnitine, choline, betaine, and TML were not associated." | 4.31 | Associations of plasma TMAO and its precursors with stroke risk in the general population: A nested case-control study. ( Gu, S; Liu, D; Ma, Z; Zhou, Z; Zuo, H, 2023) |
| "Lesional NAA and creatine were significantly lower in subacute than in acute stroke." | 4.31 | Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging. ( Bo, B; Guan, Y; Guo, R; Li, Y; Liang, ZP; Lin, DJ; Lin, Z; Liu, J; Meng, Z; Nachev, P; Wang, T; Yu, X; Zhao, Y; Zhou, H, 2023) |
| "Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment." | 4.31 | Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring. ( Hurley, L; Ille, S; Jadavji, NM; Jauhal, J; Malysheva, OV; Pull, K, 2023) |
| " We aimed to evaluate whether residual risk of recurrent stroke of TMAO and its precursor choline remain among patients who received dual-antiplatelet therapy and intensive lipid-lowering therapy and with a low inflammation level (high-sensitivity C-reactive protein <2 mg/L on admission)." | 4.12 | Residual Risk of Trimethylamine-N-Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy. ( Cheng, A; Jiang, X; Jin, A; Li, H; Li, K; Lin, J; Meng, X; Wang, Y; Xu, J; Xue, J; Zhao, M; Zheng, L, 2022) |
| "We aimed to prospectively investigate the relationships of circulating choline and betaine with cardiovascular events and recurrent stroke in patients with ischemic stroke." | 4.02 | Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke. ( Bu, X; Che, B; Du, J; He, J; Ju, Z; Miao, M; Peng, H; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2021) |
| "To assess the utility of Magnetic Resonance Spectroscopy (MRS) as a biomarker of response to L-arginine in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS)." | 3.91 | MELAS: Monitoring treatment with magnetic resonance spectroscopy. ( Chong, RA; DeGiorgio, CM; Galati, A; Hovsepian, DA; Mazumder, R; Mishra, S; Yim, C, 2019) |
| "Among our African-American participants, higher dietary choline intake was associated with a lower risk of incident ischemic stroke, and thus putative dietary benefits." | 3.88 | Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. ( Bidulescu, A; Dibaba, DT; Millard, HR; Musani, SK; Talegawkar, SA; Taylor, HA; Tucker, KL, 2018) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 3.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (intravenous administration) for stroke treatment in Europe and Japan, while USA phase III stroke clinical trials (oral administration) were disappointing." | 3.73 | CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. ( Adibhatla, RM; Hatcher, JF; Tureyen, K, 2005) |
| "NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue." | 2.70 | Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. ( Beley, A; Brunotte, F; Demougeot, C; Giroud, M; Marie, C; Rouaud, O; Walker, P, 2002) |
| "TMAO was associated with lacunar stroke but not other ischemic stroke subtypes in a model adjusted for age, sex, hypertension, diabetes, and smoking (OR, 1." | 1.91 | Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke. ( Ament, Z; Bevers, MB; Bhave, VM; Couch, CA; Garcia Guarniz, AL; Irvin, MR; Kijpaisalratana, N; Kimberly, WT, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 15 (44.12) | 24.3611 |
| 2020's | 11 (32.35) | 2.80 |
| Authors | Studies |
|---|---|
| Miao, M | 2 |
| Du, J | 2 |
| Che, B | 3 |
| Guo, Y | 1 |
| Zhang, J | 3 |
| Ju, Z | 3 |
| Xu, T | 3 |
| Zhong, X | 1 |
| Zhang, Y | 4 |
| Zhong, C | 3 |
| Diprose, WK | 1 |
| Morgan, CA | 1 |
| Wang, MT | 1 |
| Diprose, JP | 1 |
| Lin, JC | 1 |
| Sheriff, S | 1 |
| Campbell, D | 1 |
| Barber, PA | 2 |
| Xue, J | 1 |
| Xu, J | 1 |
| Zhao, M | 1 |
| Jin, A | 1 |
| Cheng, A | 1 |
| Jiang, X | 1 |
| Li, K | 1 |
| Lin, J | 1 |
| Meng, X | 1 |
| Li, H | 1 |
| Zheng, L | 1 |
| Wang, Y | 2 |
| Liu, D | 1 |
| Gu, S | 1 |
| Zhou, Z | 2 |
| Ma, Z | 1 |
| Zuo, H | 1 |
| Lin, Z | 1 |
| Meng, Z | 1 |
| Wang, T | 1 |
| Guo, R | 1 |
| Zhao, Y | 2 |
| Li, Y | 4 |
| Bo, B | 1 |
| Guan, Y | 1 |
| Liu, J | 1 |
| Zhou, H | 1 |
| Yu, X | 1 |
| Lin, DJ | 1 |
| Liang, ZP | 1 |
| Nachev, P | 1 |
| Tu, R | 1 |
| Xia, J | 1 |
| Hurley, L | 1 |
| Jauhal, J | 1 |
| Ille, S | 1 |
| Pull, K | 1 |
| Malysheva, OV | 1 |
| Jadavji, NM | 3 |
| Kijpaisalratana, N | 1 |
| Ament, Z | 1 |
| Bevers, MB | 1 |
| Bhave, VM | 1 |
| Garcia Guarniz, AL | 1 |
| Couch, CA | 1 |
| Irvin, MR | 1 |
| Kimberly, WT | 1 |
| Mosnier, H | 1 |
| Kelly, E | 1 |
| Lawrence, K | 1 |
| Cruickshank, S | 1 |
| Stacey, S | 1 |
| McCall, A | 1 |
| Dhatt, S | 1 |
| Arning, E | 1 |
| Bottiglieri, T | 1 |
| Smith, PD | 2 |
| Lu, Z | 1 |
| Qian, S | 1 |
| Zheng, X | 1 |
| Wang, A | 2 |
| Bu, X | 2 |
| Zhu, W | 1 |
| Romano, KA | 1 |
| Li, L | 1 |
| Buffa, JA | 1 |
| Sangwan, N | 1 |
| Prakash, P | 1 |
| Tittle, AN | 1 |
| Li, XS | 1 |
| Fu, X | 1 |
| Androjna, C | 1 |
| DiDonato, AJ | 1 |
| Brinson, K | 1 |
| Trapp, BD | 1 |
| Fischbach, MA | 1 |
| Rey, FE | 1 |
| Hajjar, AM | 1 |
| DiDonato, JA | 1 |
| Hazen, SL | 1 |
| Peng, H | 1 |
| He, J | 1 |
| Emmerson, JT | 1 |
| MacFarlane, AJ | 1 |
| Willmore, WG | 1 |
| Yu, W | 1 |
| Xu, C | 1 |
| Li, G | 1 |
| Hong, W | 1 |
| Xiao, C | 1 |
| Cai, Y | 2 |
| Huang, M | 1 |
| Jin, J | 1 |
| Hovsepian, DA | 1 |
| Galati, A | 1 |
| Chong, RA | 1 |
| Mazumder, R | 1 |
| DeGiorgio, CM | 1 |
| Mishra, S | 1 |
| Yim, C | 1 |
| Nie, J | 1 |
| Xie, L | 1 |
| Zhao, BX | 1 |
| Qiu, B | 1 |
| Zhu, F | 1 |
| Li, GF | 1 |
| He, M | 1 |
| Wang, B | 1 |
| Liu, S | 1 |
| Zhang, H | 1 |
| Guo, H | 1 |
| Huo, Y | 1 |
| Hou, FF | 1 |
| Xu, X | 1 |
| Qin, X | 1 |
| Mazidi, M | 1 |
| Katsiki, N | 1 |
| Mikhailidis, DP | 1 |
| Banach, M | 1 |
| Shemesh, N | 1 |
| Rosenberg, JT | 1 |
| Dumez, JN | 1 |
| Grant, SC | 1 |
| Frydman, L | 1 |
| Nagata, C | 1 |
| Wada, K | 1 |
| Tamura, T | 1 |
| Konishi, K | 1 |
| Kawachi, T | 1 |
| Tsuji, M | 1 |
| Nakamura, K | 1 |
| Millard, HR | 1 |
| Musani, SK | 1 |
| Dibaba, DT | 1 |
| Talegawkar, SA | 1 |
| Taylor, HA | 1 |
| Tucker, KL | 1 |
| Bidulescu, A | 1 |
| Delaunay, K | 1 |
| Le Jeune, F | 1 |
| Garin, E | 1 |
| Devillers, A | 1 |
| Palard-Novello, X | 1 |
| Carlson, HL | 1 |
| MacMaster, FP | 1 |
| Harris, AD | 1 |
| Kirton, A | 1 |
| Zhang, L | 2 |
| Sui, R | 1 |
| Zhang, Z | 1 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 1 |
| Armitage, PA | 1 |
| Marshall, I | 1 |
| Bastin, ME | 1 |
| Wardlaw, JM | 1 |
| An, L | 1 |
| Thomasson, DM | 1 |
| Latour, LL | 1 |
| Baker, EH | 1 |
| Shen, J | 1 |
| Warach, S | 1 |
| Huang, Y | 1 |
| Chen, W | 1 |
| Wu, X | 1 |
| Shi, X | 1 |
| Geng, D | 1 |
| Giuliani, D | 1 |
| Ottani, A | 1 |
| Altavilla, D | 1 |
| Bazzani, C | 1 |
| Squadrito, F | 1 |
| Guarini, S | 1 |
| Bender, B | 1 |
| Bornemann, A | 1 |
| Reimold, M | 1 |
| Ernemann, U | 1 |
| Horger, M | 1 |
| Ross, AJ | 1 |
| Sachdev, PS | 1 |
| Wen, W | 1 |
| Valenzuela, MJ | 1 |
| Brodaty, H | 1 |
| Adibhatla, RM | 1 |
| Hatcher, JF | 1 |
| Tureyen, K | 1 |
| Parsons, MW | 1 |
| Li, T | 1 |
| Yang, Q | 1 |
| Darby, DG | 1 |
| Desmond, PM | 1 |
| Gerraty, RP | 1 |
| Tress, BM | 1 |
| Davis, SM | 1 |
| Kimura, S | 1 |
| Saito, H | 1 |
| Minami, M | 1 |
| Togashi, H | 1 |
| Nakamura, N | 1 |
| Nemoto, M | 1 |
| Parvez, HS | 1 |
| Graham, GD | 1 |
| Hwang, JH | 1 |
| Rothman, DL | 1 |
| Prichard, JW | 1 |
| Demougeot, C | 1 |
| Walker, P | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Rouaud, O | 1 |
| Giroud, M | 1 |
| Brunotte, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inner Mongolia Stroke Project A Randomized Controlled Trial of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke in China[NCT01840072] | 4,071 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
| Enalapril Maleate and Folic Acid Tablets for Primary Prevention of Stroke in Patients With Hypertension: a Post-marketing, Double-blind, Randomized Controlled Trial.[NCT00794885] | Phase 4 | 20,702 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Major disability was defined as a score of 3 to 5 on the modified Rankin Scale at 3 months after randomization. Scores on the modified Rankin Scale range from 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability (ie, bedridden, incontinent, or requiring constant nursing care and attention); and a score of 6 indicating death (NCT01840072)
Timeframe: 3 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Usual Care | 502 |
| Active Antihypertensive Treatment | 500 |
Major disability was defined as a score of 3 to 5 on the modified Rankin Scale at 14 days after randomization. Scores on the modified Rankin Scale range from 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability (ie, bedridden, incontinent, or requiring constant nursing care and attention); and a score of 6 indicating death. (NCT01840072)
Timeframe: 2 weeks
| Intervention | participants (Number) |
|---|---|
| Usual Care | 681 |
| Active Antihypertensive Treatment | 683 |
Cognitive function was measured by Montreal Cognitive Assessment at 3 months after randomization. The MoCA is a 30-item test that evaluates the following seven cognitive domains: visuospatial/executive functions, naming, memory, attention, language, abstraction, and orientation. One point is added for participants with education <12 years. Scores on the MoCA range from 0 to 30 and cognitive impairment was defined as a score of <26. (NCT01840072)
Timeframe: Three months
| Intervention | MoCA score (Median) |
|---|---|
| Usual Care | 22 |
| Active Antihypertensive Treatment | 22 |
Cognitive function was measured by the Mini-Mental State Examination at 3 months after randomization. The MMSE contains 20 items that test cognitive performance in domains including orientation, registration, attention and calculation, recall, language, and visual construction. MMSE scores were divided into three ordinal categories: 24-30 (no cognitive impairment), 19-23 (mild cognitive impairment), and 0-17 (severe cognitive impairment). (NCT01840072)
Timeframe: Three months
| Intervention | MMSE score (Median) |
|---|---|
| Usual Care | 26 |
| Active Antihypertensive Treatment | 26 |
Those patients who were still alive at hospital discharge were contacted by telephone to set up a follow-up clinical visit. Neurological function was assessed by the modified Rankin scale at the 3-month post-treatment follow-up visit. Scores on the modified Rankin Scale range from 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability (ie, bedridden, incontinent, or requiring constant nursing care and attention); and a score of 6 indicating death. Major disability was defined as a score of 3 to 5 on the modified Rankin Scale. (NCT01840072)
Timeframe: Three months
| Intervention | Score on modified Rankin scale (Median) |
|---|---|
| Usual Care | 1.0 |
| Active Antihypertensive Treatment | 1.0 |
Those patients who are still alive at hospital discharge will be contacted by telephone to set up a follow-up clinical visit. Information on clinical deaths will be obtained. (NCT01840072)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Active Antihypertensive Treatment | 68 |
| Usual Care | 54 |
Those patients who are still alive at hospital discharge will be contacted by telephone to set up a follow-up clinical visit. Information of vascular events, such as myocardial infarction, will be collected. (NCT01840072)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Usual Care | 59 |
| Active Antihypertensive Treatment | 48 |
Those patients who are still alive at hospital discharge will be contacted by telephone to set up a follow-up clinical visit. Information of recurrent stroke will be collected. (NCT01840072)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Active Antihypertensive Treatment | 28 |
| Usual Care | 43 |
3 reviews available for choline and Stroke
| Article | Year |
|---|---|
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO.
Topics: Choline; Cognitive Dysfunction; Gastrointestinal Microbiome; Humans; Inflammation; Stroke; Thrombosi | 2024 |
Dietary choline is positively related to overall and cause-specific mortality: results from individuals of the National Health and Nutrition Examination Survey and pooling prospective data.
Topics: Adult; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Choline; Diet; Ethni | 2019 |
Melanocortins and the cholinergic anti-inflammatory pathway.
Topics: Animals; Choline; Humans; Inflammation; Melanocortins; Myocardial Infarction; Myocardial Reperfusion | 2010 |
6 trials available for choline and Stroke
| Article | Year |
|---|---|
Circulating choline pathway nutrients and depression after ischemic stroke.
Topics: Choline; Depression; Humans; Ischemic Stroke; Nutrients; Risk Factors; Stroke | 2022 |
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Topics: Aged; Antihypertensive Agents; Brain Ischemia; China; Choline; Cognition; Cognition Disorders; Cogni | 2021 |
1H MRS in stroke patients with and without cognitive impairment.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; C | 2005 |
Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Diffusion; Female; Humans; Infarction, Middl | 2000 |
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female; | 2001 |
Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity.
Topics: Aspartic Acid; Choline; Creatine; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; M | 2002 |
25 other studies available for choline and Stroke
| Article | Year |
|---|---|
Active conductive head cooling of normal and infarcted brain: A magnetic resonance spectroscopy imaging study.
Topics: Body Temperature; Brain; Brain Infarction; Choline; Creatine; Humans; Hypothermia, Induced; Magnetic | 2022 |
Residual Risk of Trimethylamine-N-Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy.
Topics: C-Reactive Protein; Choline; Humans; Inflammation; Lipids; Methylamines; Oxides; Platelet Aggregatio | 2022 |
Associations of plasma TMAO and its precursors with stroke risk in the general population: A nested case-control study.
Topics: Betaine; Carnitine; Case-Control Studies; Choline; Humans; Stroke | 2023 |
Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging.
Topics: Aspartic Acid; Bayes Theorem; Choline; Creatine; Cross-Sectional Studies; Humans; Ischemic Stroke; L | 2023 |
Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring.
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Inflammation; Ischemic Stroke; Lactation; | 2023 |
Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.
Topics: Aged; Betaine; Carnitine; Cerebral Small Vessel Diseases; Choline; Cross-Sectional Studies; Female; | 2023 |
One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
Topics: Aging; Animals; Brain; Choline; Dietary Supplements; Male; Methylenetetrahydrofolate Reductase (NADP | 2019 |
Gut microbes impact stroke severity via the trimethylamine N-oxide pathway.
Topics: Animals; Bacteria; Choline; Female; Gastrointestinal Microbiome; Humans; Male; Methylamines; Mice; M | 2021 |
Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke.
Topics: Aged; Betaine; Cardiovascular Diseases; Case-Control Studies; Choline; Female; Humans; Lipotropic Ag | 2021 |
B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.
Topics: Animals; Choline; Dietary Supplements; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mic | 2017 |
Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients.
Topics: Aged; Betaine; Choline; Chromatography, High Pressure Liquid; Female; Humans; Male; Methylamines; Pl | 2018 |
MELAS: Monitoring treatment with magnetic resonance spectroscopy.
Topics: Arginine; Aspartic Acid; Brain; Choline; Female; Humans; Magnetic Resonance Spectroscopy; MELAS Synd | 2019 |
Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients.
Topics: Aged; Carnitine; Case-Control Studies; China; Choline; Female; Folic Acid; Gastrointestinal Microbio | 2018 |
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline; | 2014 |
Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women.
Topics: Adult; Animals; Asian People; Betaine; Choline; Coronary Disease; Diet; Female; Humans; Male; Middle | 2015 |
Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study.
Topics: Adult; Aged; Aged, 80 and over; Betaine; Black People; Cardiovascular Diseases; Choline; Coronary Di | 2018 |
18F-Choline Uptake in Acute Ischemic Stroke.
Topics: Aged; Choline; Humans; Male; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; | 2017 |
Spectroscopic biomarkers of motor cortex developmental plasticity in hemiparetic children after perinatal stroke.
Topics: Adolescent; Analysis of Variance; Aspartic Acid; Cerebral Palsy; Child; Choline; Female; Glutamic Ac | 2017 |
Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression.
Topics: Anisotropy; Case-Control Studies; Cerebellum; Choline; Creatine; Depression; Female; Humans; Magneti | 2016 |
Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Choline; Creatine; Down-R | 2008 |
Measurement of glutathione in normal volunteers and stroke patients at 3T using J-difference spectroscopy with minimized subtraction errors.
Topics: Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Creatine; Female; Glutathione; Huma | 2009 |
Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy.
Topics: Aged; Analysis of Variance; Antidepressive Agents; Aspartic Acid; Brain Mapping; Case-Control Studie | 2010 |
[Imaging findings in autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) - CADASIL - the most frequent familial stroke syndrome].
Topics: Aged; Brain; CADASIL; Choline; Chromosome Aberrations; Dementia, Vascular; Diffusion Magnetic Resona | 2012 |
CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cholesterol; Choline; Cytidine Diphosphate Choline | 2005 |
Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Aged; Animals; Behavior, Animal; Brain; Brain Chemistry; Cerebral Infarction; Choline | 2000 |