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choline and Sensitivity and Specificity

choline has been researched along with Sensitivity and Specificity in 413 studies

Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Research Excerpts

ExcerptRelevanceReference
"The presence of residual bladder cancer (pTa-pT4) was correctly detected in 21 of 25 histologically tumor-positive patients (84%) by CT and in 24 of 25 patients (96%) by (11)C-choline PET."9.12Value of 11C-choline PET and contrast-enhanced CT for staging of bladder cancer: correlation with histopathologic findings. ( Beer, AJ; Bössner, P; Hartung, R; Metz, S; Paul, R; Picchio, M; Piert, M; Schwaiger, M; Souvatzoglou, M; Treiber, U; van Randenborgh, H; Weirich, G, 2006)
"The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma."9.12[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007)
"We aimed to assess the diagnostic accuracy of C-11 choline and C-11 acetate positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging in bladder cancer (BC) patients through a systematic review and meta-analysis."8.98Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis. ( Kim, IJ; Kim, K; Kim, SJ; Koo, PJ; Pak, K, 2018)
"This meta-analysis indicated 11C-choline has high diagnostic accuracy for the identification of tumor relapse from radiation induced necrosis in gliomas."8.98Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis. ( Chen, G; Gao, L; Li, T; Xu, W; Zheng, J, 2018)
"A decision tree modeled patients who underwent parathyroidectomy for primary hyperparathyroidism using single preoperative localization modalities: (1) positron emission tomography using radiolabeled 18F-fluorocholine, (2) 4-dimensional computed tomography, (3) ultrasound, and (4) sestamibi single photon emission computed tomography (SPECT)."8.12A cost-utility analysis of 18F-fluorocholine-positron emission tomography imaging for localizing primary hyperparathyroidism in the United States. ( Duh, QY; Gosnell, JE; Graves, CE; Hope, TA; Kluijfhout, W; Roman, SA; Shen, WT; Sosa, JA; Suh, I; Yap, A, 2022)
"In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting."7.81Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma. ( Ceriani, R; Chiti, A; Comito, T; de Neto, LJ; Donadon, M; Lanza, E; Lopci, E; Palmisano, A; Pedicini, V; Personeni, N; Poretti, D; Rimassa, L; Sabongi, JG; Scorsetti, M; Torzilli, G, 2015)
"The aim of this study is to assess the different metabolic activities characteristic of glioma recurrence and radiation necrosis (RN) and to explore the diagnostic accuracy for differentiation of the two conditions using (11)C-methionine (MET), (11)C-choline (CHO), and (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)."7.80Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis. ( Asano, Y; Iwama, T; Miwa, K; Nomura, Y; Shinoda, J; Takenaka, S; Yano, H; Yonezawa, S, 2014)
"The relative amounts of choline (Cho), phosphocholine (PC), and glycerophosphocholine (GPC) may be sensitive indicators of breast cancer and the degree of malignancy."7.791H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer. ( Cecil, KM; Chu, WJ; Komoroski, RA; Lee, JH; Mahoney, MC; Pearce, JM; Strakowski, SM, 2013)
" Choline is known to occur in high concentrations in seminal fluid and the Florence Iodine test for its detection has been used in forensic science for many years, however very little is documented regarding its sensitivity and specificity in forensic casework."7.79Optimisation of choline testing using Florence Iodine reagent, including comparative sensitivity and specificity with PSA and AP tests. ( Allard, J; Hardinge, P; Wain, A; Watson, S, 2013)
"The association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) status of breast cancer patients with total choline (tCho) concentration and tumor volume was investigated using in vivo proton magnetic resonance spectroscopy and MRI at 1."7.78Association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status with total choline concentration and tumor volume in breast cancer patients: an MRI and in vivo proton MRS study. ( Jagannathan, NR; Mathur, SR; Parshad, R; Sah, RG; Seenu, V; Sharma, U, 2012)
"To investigate which transmembrane choline transporters and intracellular choline kinases play a prominent role at gene expression level in the rise of the total choline (tCho) peak at proton MR spectra in a rodent rhabdomyosarcoma model."7.78Enhanced choline metabolism in a rodent rhabdomyosarcoma model: correlation between RT-PCR and translational 3 T H-MRS. ( Abarca-Quinones, J; De Saeger, C; Duprez, T; Leclercq, I; Peeters, F; Rommel, D, 2012)
"PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy."7.74Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy. ( Ağildere, AM; Atalay, B; Elhan, AH; Geyik, E; Ozen, O; Yerli, H, 2007)
"2 ppm, which includes contributions from choline, phosphocholine (PC), glycerophosphocholine (GPC), myo-inositol and taurine, was found not to be a unique marker for malignancy providing a diagnostic sensitivity and specificity of 80."7.73Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T. ( Baker, L; Clark, D; Giuffrè, B; Gluch, L; Lean, C; Malycha, P; Mountford, C; Stanwell, P; Tomanek, B, 2005)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."7.73Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies."6.78The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy. ( Bennink, RJ; Beuers, U; Bieze, M; El-Massoudi, Y; Phoa, SS; van Gulik, TM; Verheij, J, 2013)
"In seven patients, no residual tumour was found after surgery."6.70Visualisation of bladder cancer using (11)C-choline PET: first clinical experience. ( de Jong, IJ; Elsinga, PH; Jongen, MM; Mensink, HJ; Pruim, J; Vaalburg, W, 2002)
"Choline has been identified as a promising marker of coronary inflammation, plaque destabilisation and ischaemia."5.35Choline for diagnosis and prognostication of acute coronary syndromes in the Emergency Department. ( Body, R; Carley, S; Ferguson, J; Griffith, CA; Keevil, B; Mackway-Jones, K; McDowell, G, 2009)
"A choline peak was present in 34 of 57 lesions (including all cancers) and in three of 26 benign lesions, giving MR spectroscopy a sensitivity of 100% and a specificity of 88%."5.33Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study. ( Bartella, L; Dershaw, DD; Guido, J; Huang, W; Liberman, L; Morris, EA; Moskowitz, C; Thakur, SB, 2006)
"11C-choline PET was very effective in detecting lymph node metastases in the mediastinum originating from NSCLC, with a sensitivity of 100%."5.31Sensitive detection of mediastinal lymph node metastasis of lung cancer with 11C-choline PET. ( Hara, T; Inagaki, K; Kosaka, N; Morita, T, 2000)
"The presence of residual bladder cancer (pTa-pT4) was correctly detected in 21 of 25 histologically tumor-positive patients (84%) by CT and in 24 of 25 patients (96%) by (11)C-choline PET."5.12Value of 11C-choline PET and contrast-enhanced CT for staging of bladder cancer: correlation with histopathologic findings. ( Beer, AJ; Bössner, P; Hartung, R; Metz, S; Paul, R; Picchio, M; Piert, M; Schwaiger, M; Souvatzoglou, M; Treiber, U; van Randenborgh, H; Weirich, G, 2006)
"The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma."5.12[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007)
"We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy."5.09Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001)
"We aimed to assess the diagnostic accuracy of C-11 choline and C-11 acetate positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging in bladder cancer (BC) patients through a systematic review and meta-analysis."4.98Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis. ( Kim, IJ; Kim, K; Kim, SJ; Koo, PJ; Pak, K, 2018)
"This meta-analysis indicated 11C-choline has high diagnostic accuracy for the identification of tumor relapse from radiation induced necrosis in gliomas."4.98Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis. ( Chen, G; Gao, L; Li, T; Xu, W; Zheng, J, 2018)
"A decision tree modeled patients who underwent parathyroidectomy for primary hyperparathyroidism using single preoperative localization modalities: (1) positron emission tomography using radiolabeled 18F-fluorocholine, (2) 4-dimensional computed tomography, (3) ultrasound, and (4) sestamibi single photon emission computed tomography (SPECT)."4.12A cost-utility analysis of 18F-fluorocholine-positron emission tomography imaging for localizing primary hyperparathyroidism in the United States. ( Duh, QY; Gosnell, JE; Graves, CE; Hope, TA; Kluijfhout, W; Roman, SA; Shen, WT; Sosa, JA; Suh, I; Yap, A, 2022)
"In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting."3.81Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma. ( Ceriani, R; Chiti, A; Comito, T; de Neto, LJ; Donadon, M; Lanza, E; Lopci, E; Palmisano, A; Pedicini, V; Personeni, N; Poretti, D; Rimassa, L; Sabongi, JG; Scorsetti, M; Torzilli, G, 2015)
"The aim of this study is to assess the different metabolic activities characteristic of glioma recurrence and radiation necrosis (RN) and to explore the diagnostic accuracy for differentiation of the two conditions using (11)C-methionine (MET), (11)C-choline (CHO), and (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)."3.80Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis. ( Asano, Y; Iwama, T; Miwa, K; Nomura, Y; Shinoda, J; Takenaka, S; Yano, H; Yonezawa, S, 2014)
"The aim of this study is to evaluate uptake of 2-(18)F-fluoroethyl-bis(zinc(II)-dipicolylamine) ((18)F-FEN-DPAZn2) as a promising cell death imaging agent, a choline analog (18)F-fluoroethylcholine ((18)F-FECH), (18)F-fluoride as a bone imaging agent, and a glucose analog 2-(18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG) in the combined S180 fibrosarcoma and turpentine-induced inflammation mice models."3.80Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation. ( Hu, K; Huang, T; Liang, X; Nie, D; Sun, T; Tang, G; Tang, X; Wang, H, 2014)
"The relative amounts of choline (Cho), phosphocholine (PC), and glycerophosphocholine (GPC) may be sensitive indicators of breast cancer and the degree of malignancy."3.791H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer. ( Cecil, KM; Chu, WJ; Komoroski, RA; Lee, JH; Mahoney, MC; Pearce, JM; Strakowski, SM, 2013)
" Choline is known to occur in high concentrations in seminal fluid and the Florence Iodine test for its detection has been used in forensic science for many years, however very little is documented regarding its sensitivity and specificity in forensic casework."3.79Optimisation of choline testing using Florence Iodine reagent, including comparative sensitivity and specificity with PSA and AP tests. ( Allard, J; Hardinge, P; Wain, A; Watson, S, 2013)
"The association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) status of breast cancer patients with total choline (tCho) concentration and tumor volume was investigated using in vivo proton magnetic resonance spectroscopy and MRI at 1."3.78Association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status with total choline concentration and tumor volume in breast cancer patients: an MRI and in vivo proton MRS study. ( Jagannathan, NR; Mathur, SR; Parshad, R; Sah, RG; Seenu, V; Sharma, U, 2012)
"To investigate which transmembrane choline transporters and intracellular choline kinases play a prominent role at gene expression level in the rise of the total choline (tCho) peak at proton MR spectra in a rodent rhabdomyosarcoma model."3.78Enhanced choline metabolism in a rodent rhabdomyosarcoma model: correlation between RT-PCR and translational 3 T H-MRS. ( Abarca-Quinones, J; De Saeger, C; Duprez, T; Leclercq, I; Peeters, F; Rommel, D, 2012)
" Test-retest [(11)C]choline scans of nine patients with breast cancer were considered and the percent test-retest variability %VAR(TEST-RETEST) of tumor volume (TV) was employed to assess the results."3.78Comparative assessment of segmentation algorithms for tumor delineation on a test-retest [(11)C]choline dataset. ( Aboagye, E; Shepherd, T; Tomasi, G; Turkheimer, F; Visvikis, D, 2012)
"Metabolite maps of N-acetyl aspartate, choline and creatine were generated using (1)H-CSI data from the brain of healthy volunteers and patients with tumor and epilepsy."3.76Grid-free interactive and automated data processing for MR chemical shift imaging data. ( Confort-Gouny, S; Cozzone, PJ; Guye, M; Kober, F; Le Fur, Y; Nicoli, F, 2010)
"PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy."3.74Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy. ( Ağildere, AM; Atalay, B; Elhan, AH; Geyik, E; Ozen, O; Yerli, H, 2007)
"To retrospectively compare sensitivity and specificity of magnetic resonance (MR) imaging, three-dimensional (3D) MR spectroscopy, combined MR imaging and 3D MR spectroscopy, and carbon 11 (11C)-choline positron emission tomography (PET)/computed tomography (CT) for intraprostatic tumor sextant localization, with histologic findings as reference standard."3.74Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT. ( Barbiroli, B; Brunocilla, E; Canini, R; Castellucci, P; Coe, M; Corti, B; Fanti, S; Farsad, M; Grigioni, WF; Kurhanewicz, J; Lodi, R; Manferrari, F; Martorana, G; Monetti, N; Salizzoni, E; Schiavina, R; Testa, C; Tonon, C, 2007)
" C-choline can achieve high contrast of brain tumour imaging and was expected to have higher sensitivity and specificity."3.74Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours. ( Guan, Y; Huang, Z; Lin, X; Liu, P; Xue, F; Zhang, Z; Zuo, C, 2008)
"2 ppm, which includes contributions from choline, phosphocholine (PC), glycerophosphocholine (GPC), myo-inositol and taurine, was found not to be a unique marker for malignancy providing a diagnostic sensitivity and specificity of 80."3.73Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T. ( Baker, L; Clark, D; Giuffrè, B; Gluch, L; Lean, C; Malycha, P; Mountford, C; Stanwell, P; Tomanek, B, 2005)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."3.73Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"By comparing the intensity of resonances assigned to choline, creatine, lipid, and lysine, MR spectroscopy can depict prostate carcinoma with a high degree of sensitivity and specificity."3.72Pathologic characterization of human prostate tissue with proton MR spectroscopy. ( Himmelreich, U; Khadra, M; Lean, C; McCredie, S; Mountford, C; Russell, P; Swindle, P, 2003)
"To assess the relationship between breast cancer subtypes and choline detection by using in vivo proton magnetic resonance (MR) spectroscopy and to assess the feasibility of proton MR spectroscopy in the study of axillary lymph node metastases."3.71Breast cancer: in vivo proton MR spectroscopy in the characterization of histopathologic subtypes and preliminary observations in axillary node metastases. ( Tse, GM; Yang, WT; Yeung, DK, 2002)
" MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis."3.71[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002)
" We compared the LR sensitivity, specificity, and receiver operator characteristic (ROC) curve area (Az) with the sensitivity and specificity of blinded and unblinded qualitative MRS interpretations and a choline (Cho)/N-acetylaspartate (NAA) amplitude ratio criterion."3.70Discrimination between neoplastic and nonneoplastic brain lesions by use of proton MR spectroscopy: the limits of accuracy with a logistic regression model. ( Bowen, W; Butzen, J; Chetty, V; Donahue, K; Haughton, V; Kim, T; Krouwer, H; Li, SJ; Mark, L; Meyer, G; Mueller, W; Neppl, R; Prost, R; Rand, S, 2000)
"Choline-PET/CT has a high global sensitivity while WB-DW-MRI has a high specificity, and so they are complementary techniques."2.84Whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) vs choline-positron emission tomography-computed tomography (choline-PET/CT) for selecting treatments in recurrent prostate cancer. ( Broseta-Torres, R; Conde-Moreno, AJ; Cozar-Santiago, MP; Ferrer-Albiach, C; Ferrer-Rebolleda, J; García-Piñón, F; Herrando-Parreño, G; Muelas-Soria, R, 2017)
"Twelve prostate cancer patients (nine staging, three re-staging) were included."2.80BAY 1075553 PET-CT for Staging and Restaging Prostate Cancer Patients: Comparison with [18F] Fluorocholine PET-CT (Phase I Study). ( Beheshti, M; Dinkelborg, L; Haim, S; Kunit, T; Langsteger, W; Loidl, W; Schiller, C; Stephens, A; Zakavi, R, 2015)
"The pretherapeutic assessment of prostate cancer is challenging and still holds the risk of over- or undertreatment."2.79Combined PET/MRI improves diagnostic accuracy in patients with prostate cancer: a prospective diagnostic trial. ( Bechtloff, W; Danz, B; Hacker, M; Hartenbach, M; Hartenbach, S; Klemenz, B; Kraft, K; Sparwasser, C, 2014)
"Twenty-one patients with cervical spondylosis and eleven healthy controls were evaluated."2.78Proton magnetic resonance spectroscopy of human cervical spondylosis at 3T. ( Ellingson, BM; Gebara, N; Holly, LT; Nagarajan, R; Salamon, N; Thomas, A, 2013)
"Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies."2.78The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy. ( Bennink, RJ; Beuers, U; Bieze, M; El-Massoudi, Y; Phoa, SS; van Gulik, TM; Verheij, J, 2013)
"F-fluorocholine (FCH) is a lipid analogue for PET imaging, with advantages in terms of logistics and image resolution."2.75Detection of bronchioloalveolar cancer by means of PET/CT and 18F-fluorocholine, and comparison with 18F-fluorodeoxyglucose. ( Antoine, M; Balogova, S; Cadranel, J; Gutman, F; Huchet, V; Kerrou, K; Lavolée, A; Mayaud, C; Montravers, F; Nataf, V; Prignon, A; Ruppert, AM; Talbot, JN, 2010)
"Late infantile metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder that causes severe demyelination of the nervous system."2.75Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. ( Barton, NW; Fogh, J; Hanson, LG; i Dali, C; Lund, AM; Nair, N, 2010)
"Dementia was an independent predictor of metabolite values."2.73Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008)
"Twenty-six men (15 newly diagnosed with prostate cancer, 2 with recurrent prostate cancer, 6 with no evidence of prostate cancer recurrence after treatment, and 3 with no history of prostate cancer) underwent dual-phase PET consisting of initial whole-body PET starting 7 min after injection of 3."2.72Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET. ( Coel, MN; Kwee, SA; Sesterhenn, I; Wei, H; Yun, D, 2006)
"Lung cancers were analysed visually and semiquantitatively using the ratio of tumour-to-normal radioactivity (T/N ratio) and standardized uptake value (SUV)."2.71A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer. ( Endo, K; Higuchi, T; Inoue, T; Khan, N; Oriuchi, N; Sato, N; Tian, M; Zhang, H, 2003)
"11C-choline PET is a feasible technique for evaluation of treatment for localized prostate cancer."2.7111C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer. ( de Jong, IJ; Elsinga, PH; Mensink, HJ; Pruim, J; Vaalburg, W, 2003)
"For the diagnosis of recurrent ovarian cancer (n = 3), (11)C-choline PET and (18)F-FDG PET were true-positive in 1 patient, whereas neither tracer could detect cystic recurrent tumor and microscopic peritoneal disease in the other 2 patients."2.71Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET. ( Futatsubashi, M; Kanno, T; Maeda, M; Nakamura, F; Okada, H; Ouchi, Y; Takekuma, M; Torizuka, T; Yoshikawa, E, 2003)
"Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study."2.71MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms. ( Liu, Y; Ruan, LX; Shang, DS; Yuan, M; Zhang, LJ; Zheng, XN; Zhu, XC, 2004)
"In seven patients, no residual tumour was found after surgery."2.70Visualisation of bladder cancer using (11)C-choline PET: first clinical experience. ( de Jong, IJ; Elsinga, PH; Jongen, MM; Mensink, HJ; Pruim, J; Vaalburg, W, 2002)
"The pooled specificities for bone metastases detection using CH-PET/CT, WB-MRI, and BS were 99% (95% CI, 93-100%), 95% (95% CI, 90-97%), and 82% (95% CI, 78-85%), respectively."2.55Rationale for Modernising Imaging in Advanced Prostate Cancer. ( Collins, DJ; de Bono, J; De Keyzer, F; Fanti, S; Koh, DM; Lecouvet, FE; Padhani, AR; Petralia, G; Sala, E; Schlemmer, HP; Tombal, B; Tunariu, N; Vargas, HA, 2017)
"PET/CT imaging in men with prostate cancer (PCa) is rapidly growing as clinicians are becoming aware of its possible fundamental role in the diagnostic flow chart of these patients."2.53Rapidly changing landscape of PET/CT imaging in prostate cancer. ( Fanti, S; Hofman, MS; Morigi, JJ; Murphy, D, 2016)
"We review its use in cancer diagnosis, staging, restaging, and assessment of response to treatment."2.47Metabolic positron emission tomography imaging in cancer detection and therapy response. ( Lee, D; Shim, H; Zhu, A, 2011)
"Prostate cancer is a major health problem, and the exploration of noninvasive imaging methods that have the potential to improve specificity while maintaining high sensitivity is still critically needed."2.44Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer. ( Jacobs, MA; Macura, KJ; Ouwerkerk, R; Petrowski, K, 2008)
"The role of PET imaging in prostate cancer is gradually evolving but still remains within the experimental realm."2.44Is there a role for positron emission tomography imaging in the early evaluation of prostate cancer relapse? ( Cascini, GL; Greco, C; Tamburrini, O, 2008)
"The fluorocholine PET/CT was positive for 81% and negative for 19% of patients."1.56Diagnostic performance of imaging techniques for detecting of local recurrence after prostate brachytherapy. ( Blais, E; Cazeau, AL; De Vaugelade, C; Fontes, F; Hindié, E; Karahissarlian, V; Mariey, A; Petitpierre, F; Rigou, G; Sargos, P; Thomas, L, 2020)
"FECH PET/CT showed findings of prostate cancer in 46/56 lobes (82%)."1.43 ( Ahmed, HU; Almuhaideb, A; Bomanji, J; Cathcart, P; Dickson, J; Emberton, M; Freeman, A; Haroon, A; Kayani, I; Kirkham, A, 2016)
"Clinical management of prostate cancer increasingly aims to distinguish aggressive types that require immediate and radical treatment from indolent tumors that are candidates for watchful waiting."1.42Non-invasive estimation of prostate cancer aggressiveness using diffusion-weighted MRI and 3D proton MR spectroscopy at 3.0 T. ( Busse, H; Do, M; Franz, T; Garnov, N; Horn, LC; Kahn, T; Moche, M; Otto, J; Stolzenburg, JU; Thörmer, G, 2015)
"Creatine levels were greater in GM than WM (57 vs."1.42Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults. ( Andrews, PJ; Armitage, PA; Deary, IJ; Harris, BA; Marshall, I; Murray, C; Parikh, J; Starr, JM; Thrippleton, MJ; Wardlaw, JM, 2015)
"A choline peak was detected in 16 malignant masses (69."1.42Improved Diagnostic Accuracy in Characterization of Adnexal Masses by Detection of Choline Peak Using 1H MR Spectroscopy in Comparison to Internal Reference at 3 Tesla. ( Gilani, MM; Gity, M; Malek, M; Pourashraf, M, 2015)
"The reviewers assessed for local recurrence in the prostatectomy bed as well as LN and bone metastases, rating their diagnostic confidence with a 5-point scoring system for each location."1.40Detection of recurrent prostate cancer after radical prostatectomy: comparison of 11C-choline PET/CT with pelvic multiparametric MR imaging with endorectal coil. ( Froemming, AT; Hagen, CE; Kawashima, A; Kitajima, K; Murphy, RC; Nathan, MA; Takahashi, N, 2014)
"The model predicted clinical ketosis with a sensitivity of 100% and a specificity of 100%."1.40(1)H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis. ( Shu, S; Sun, LW; Wu, L; Xia, C; Xu, C; Zhang, HY; Zheng, JS, 2014)
"Prostate cancer is common and may be treated immediately or managed conservatively by observation."1.40Multiparametric 3T MRI in the evaluation of intraglandular prostate cancer: correlation with histopathology. ( Bergen, N; Duchesne, G; Ferris, N; Frydenberg, M; Mills, J; Mitchell, C; Murphy, D; Pedersen, J; Styles, C, 2014)
"Recurrent prostate cancer is usually treated by combining radiotherapy and androgen deprivation therapy."1.39Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer. ( Breeuwsma, AJ; de Jong, IJ; Dost, RJ; Glaudemans, AW, 2013)
"Choline was only found in six benign lesions."1.39Study of single voxel 1H MR spectroscopy of bone tumors: differentiation of benign from malignant tumors. ( Cheng, K; Cheng, X; Ding, Y; Liang, W; Vanel, D; Zhang, J, 2013)
"11C-Choline PET was positive in 124/185 cases (65%) (in 22/61 (36%) after RP, 102/124 (82%) after EBRT)."1.39Impact of total PSA, PSA doubling time and PSA velocity on detection rates of 11C-Choline positron emission tomography in recurrent prostate cancer. ( Breeuwsma, AJ; de Jong, IJ; Dierckx, RA; Leliveld, AM; Pruim, J; Rybalov, M, 2013)
"The androgen-dependent human prostate cancer cell line LNCaP was implanted subcutaneously into the left flanks of 17 SCID-mice, 12."1.39[[¹¹C]choline as a pharmacodynamic marker for docetaxel therapy. Response assessment in a LNCaP prostate cancer xenograft mouse model]. ( Krause, BJ; Nawroth, R; Sachs, D; Schuster, T; Schwaiger, M; Schwarzenböck, S; Senekowitsch-Schmidtke, R; Souvatzoglou, M; Treiber, U; Weirich, G; Wester, HJ; Ziegler, S, 2013)
"Choline was detected in 18/19 patients with malignant tumours and in 3/18 patients with benign lesions."1.38In vivo characterisation of soft tissue tumours by 1.5-T proton MR spectroscopy. ( Aglietta, M; Anselmetti, GC; De Rosa, G; Grignani, G; Mazzetti, S; Regge, D; Russo, F; Stasi, M, 2012)
"Forty-nine prostate cancer patients underwent T2w MRI and (11)C-choline PET-CT before radical prostatectomy and extended lymphadenectomy."1.38Is there an additional value of ¹¹C-choline PET-CT to T2-weighted MRI images in the localization of intraprostatic tumor nodules? ( Bormans, G; Budiharto, T; Deroose, CM; Haustermans, K; Isebaert, S; Joniau, S; Koole, M; Lerut, E; Mottaghy, F; Oyen, R; Van den Bergh, L; Van Poppel, H, 2012)
"Nine patients with Parkinson's disease and eight age- and gender-matched healthy controls were included in this study."1.37Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's disease. ( Berg, D; Chadzynski, G; Godau, J; Gröger, A; Klose, U, 2011)
"Eight men with prostate cancer who had (11)C-choline PET scans prior to radical prostatectomy were studied."1.37Histopathological correlation of (11)C-choline PET scans for target volume definition in radical prostate radiotherapy. ( Bolton, D; Chang, JH; Clouston, D; Davis, ID; Gong, SJ; Hamilton, CS; Joon, DL; Khoo, V; Lee, ST; Scott, AM, 2011)
"Thirty-eight patients with prostate cancer (PCa) and thirty-three patients with benign prostate hyperplasia (BPH) were included in this study."1.361H-MRSI of prostate cancer: the relationship between metabolite ratio and tumor proliferation. ( Gao, ZQ; Liu, JG; Liu, ZQ; Niu, QL; Sun, ZK; Wang, B; Wang, XZ; Yuan, YX, 2010)
"Detection of recurrence in prostate cancer patients with biochemical failure after radical prostatectomy by [(11)C]choline PET/CT depends on the prostate-specific antigen (PSA) level."1.36Predictive factors of [(11)C]choline PET/CT in patients with biochemical failure after radical prostatectomy. ( Bettinardi, V; Coradeschi, E; Cozzarini, C; Di Muzio, N; Fazio, F; Gianolli, L; Giovacchini, G; Messa, C; Picchio, M; Rigatti, P; Scattoni, V, 2010)
"For LN metastases greater than or equal to 5 mm in diameter, sensitivity, specificity, and positive and negative predictive values were 66%, 96%, 82%, and 92%, respectively."1.3618F choline PET/CT in the preoperative staging of prostate cancer in patients with intermediate or high risk of extracapsular disease: a prospective study of 130 patients. ( Beheshti, M; Broinger, G; Gruy, B; Imamovic, L; Janetschek, G; Langsteger, W; Nader, M; Stoiber, F; Vali, R; Waldenberger, P, 2010)
"We report 12 cases of Gliomatosis cerebri (GC), a rare brain neoplasm, to define its semeiologic criteria."1.36Gliomatosis cerebri, imaging findings of 12 cases. ( Cosnard, G; de Coene, B; Desclée, P; Godfraind, C; Hernalsteen, D; Rommel, D, 2010)
"Sixteen prostate cancer patients were evaluated (7 for staging and 9 for restaging)."1.36Pilot comparison of F-fluorocholine and F-fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer. ( Beauregard, JM; Degrado, TR; Hicks, RJ; Roselt, P; Williams, SG, 2010)
"The results suggest improved breast cancer detection through the combination of morphological and enhancement information from DCE-MRI and metabolic information from 2D MRS."1.36Combined DCE-MRI and single-voxel 2D MRS for differentiation between benign and malignant breast lesions. ( Bassett, LW; Debruhl, N; Lipnick, S; Liu, X; Sayre, J; Thomas, MA, 2010)
"C-11 choline PET/CT is a valuable noninvasive imaging technology in the diagnosis of PCa."1.35C-11 choline PET/CT imaging for differentiating malignant from benign prostate lesions. ( Jin, X; Li, J; Li, X; Liu, Q; Liu, S; Wang, M; Yao, S, 2008)
"Choline has been identified as a promising marker of coronary inflammation, plaque destabilisation and ischaemia."1.35Choline for diagnosis and prognostication of acute coronary syndromes in the Emergency Department. ( Body, R; Carley, S; Ferguson, J; Griffith, CA; Keevil, B; Mackway-Jones, K; McDowell, G, 2009)
"Choline was detected in 10/12 primary tumors and 5/11 metastatic lesions (range 2."1.35Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T. ( Brenton, JD; Crawford, R; Earl, H; Griffiths, JR; Joubert, I; Kataoka, MY; Lomas, DJ; McLean, MA; Priest, AN; Sala, E, 2009)
"18F-choline uptake was defined as focal, multifocal or inhomogeneous."1.35The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer. ( Gallowitsch, HJ; Gomez-Segovia, I; Igerc, I; Kohlfürst, S; Kresnik, E; Lind, P; Matschnig, S, 2008)
"Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder."1.351H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders. ( Azizian, A; DeVincent, C; Gabis, L; Kesner-Baruch, Y; Pomeroy, J; Roche, P; Tudorica, A, 2008)
"Prevalence of prostate cancer in this selected patient population was 63."1.34Value of 11C-choline PET and PET/CT in patients with suspected prostate cancer. ( Albinger, W; Becker, HC; Dresel, S; Gildehaus, FJ; Scher, B; Scherr, M; Seitz, M; Souvatzogluou, M; Tiling, R; Wester, HJ, 2007)
"Choline SNRs were different for malignant and benign lesions (11."1.34Characterization of musculoskeletal lesions on 3-T proton MR spectroscopy. ( Barker, PB; Bluemke, DA; Eng, J; Fayad, LM; Jacobs, MA; Kulesza, P; Weber, KL, 2007)
"In all, 50 patients with prostate cancer who had had initial therapy (radical prostatectomy in 40, external beam radiation in three and interstitial brachytherapy in seven) had PET/CT using [(11)C]-choline in the presence of an increased or increasing prostate-specific antigen (PSA) level."1.34Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer. ( Blumstein, NM; Gschwend, JE; Hautmann, RE; Hohl, K; Kuefer, R; Möller, P; Mottaghy, FM; Reske, SN; Rinnab, L; Wiegel, T, 2007)
" Dose-response curves were generated for each inhibitor and IC(50) values were determined to be 76 microM for 6 and 21 microM for 7."1.34Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. ( Cai, S; Hudson, RA; Kirchhoff, JR; Mukherjee, J; Tillekeratne, LM, 2007)
"11C-choline was used as PET tracers to visualize various masses."1.34[The value of dual time point 11C-choline PET-CT in differentiating malignant from benign lesion of mediastinum]. ( Chen, JH; Liu, Q; Liu, QW; Meng, L; Peng, ZM; Yao, SZ, 2007)
"Choline was 231-306% higher than when the original AACC method was used."1.33Application of bubble separation for quantitative analysis of choline in Dioscorea (yam) tubers. ( Chen, SH; Fu, YC; Huang, PY; Li, YJ, 2005)
"Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed."1.33Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. ( Bezabeh, T; Kerr, P; Nason, R; Odlum, O; Patel, R; Smith, IC; Sutherland, D, 2005)
" The dose-response for choline (0-50 microM) was established in buffer and was applicable to the quantification of choline in human plasma."1.33Rapid high-throughput detection of peroxide with an acridinium-9-carboxamide: a homogeneous chemiluminescent assay for plasma choline. ( Adamczyk, M; Brashear, RJ; Mattingly, PG, 2006)
"Cerebral metabolism in chronic renal failure (CRF) patients has not been fully evaluated."1.33Positive correlations between cerebral choline and renal dysfunction in chronic renal failure. ( Hattori, N; Inenaga, T; Inoue, N; Kawano, Y; Kohno, S; Nakahama, H; Nakamura, S; Sasaki, O; Sawada, T, 2006)
"A choline peak was present in 34 of 57 lesions (including all cancers) and in three of 26 benign lesions, giving MR spectroscopy a sensitivity of 100% and a specificity of 88%."1.33Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study. ( Bartella, L; Dershaw, DD; Guido, J; Huang, W; Liberman, L; Morris, EA; Moskowitz, C; Thakur, SB, 2006)
"In 43 patients with known prostate cancer who had received positron emission tomography/computerized tomography before initial biopsy, we assessed sensitivity of positron emission tomography/computerized tomography for localization of nodules 5 mm or greater (those theoretically large enough for visualization) using radical prostatectomy histopathology as the reference standard."1.3311C-choline positron emission tomography/computerized tomography for tumor localization of primary prostate cancer in comparison with 12-core biopsy. ( Bertaccini, A; Brunocilla, E; Canini, R; Castellucci, P; Corti, B; D'Errico Grigioni, A; Fanti, S; Farsad, M; Grigioni, WF; Manferrari, F; Martorana, G; Salizzoni, E; Schiavina, R, 2006)
"Choline peak in vivo is a specific but not sensitive marker of malignancy."1.33Evaluation of spectral selected press sequence in breast lesion characterization. ( Bao, RX; Liu, PF; Lu, H; Sun, F, 2006)
"Prostate cancer is known for its difficulties in preoperative staging of pelvic lymph nodes by conventional imaging techniques."1.32Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET. ( de Jong, IJ; Elsinga, PH; Mensink, HJ; Pruim, J; Vaalburg, W, 2003)
"Several (31)P MRS studies in tumors in vivo have shown that levels of phosphocholine (PC) and other phosphomonoesters (PME) and phosphodiesters (PDE) are useful prognostic or early-response indicators."1.32Comparison of polarization transfer sequences for enhancement of signals in clinical 31P MRS studies. ( Leach, MO; Mancini, L; Payne, GS, 2003)
"Ninety-seven patients with untreated lung cancer, 14 patients with untreated pulmonary tuberculosis, and 5 patients with untreated atypical mycobacterial infection were examined."1.32Uptake rates of 18F-fluorodeoxyglucose and 11C-choline in lung cancer and pulmonary tuberculosis: a positron emission tomography study. ( Hara, T; Kosaka, N; Kudo, K; Niino, H; Suzuki, T, 2003)
"Choline was observed in all 19 cancer patients, while it was not detected in all other benign diseases."1.32In vivo 1H-MRS evaluation of malignant and benign breast diseases. ( Chung, DS; Kim, JK; Kim, OD; Lee, HM; Lee, YH; Park, SH; Sung, NK, 2003)
"Choline was detected in 18 of 19 patients with malignant tumors and in three of 17 patients with benign lesions."1.32Characterization of bone and soft-tissue tumors with in vivo 1H MR spectroscopy: initial results. ( Chien, SH; Hsieh, TJ; Li, CW; Liu, GC; Tsai, KB; Wang, CK, 2004)
"[11C]Choline is a potential tracer to detect tumors, especially brain and prostate cancers."1.32Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate. ( Fujibayashi, Y; Furukawa, T; Obata, A; Waki, A; Yonekura, Y; Yoshimoto, M, 2004)
"The diagnosis and therapy of childhood brain tumors, most of which are low grade, can be complicated because of their frequent adjacent location to crucial structures, which limits diagnostic biopsy."1.32Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. ( Anthony, DC; Astrakas, LG; Black, PM; De Girolami, U; Tarbell, NJ; Tzika, AA; Zarifi, MK; Zurakowski, D, 2004)
"Definitive diagnosis of head and neck cancer is generally made by histopathologic evaluation."1.31An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region. ( Ahing, S; Bezabeh, T; El-Sayed, S; MacDonald, K; Odlum, O; Patel, R; Smith, IC; Somorjai, RL, 2002)
"Eight patients with PTSD and 5 control subjects underwent single-voxel 1H-MRS of the hippocampi and bilateral OWM."1.31Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results. ( Brooks, WM; Griego, JA; Hamilton, DA; Hart, BL; Horan, WP; Moreshead, M; Petropoulos, H; Rowland, LM; Villarreal, G, 2002)
"The exact staging of prostate cancer is mandatory to allow selection of the appropriate primary therapy."1.31[The (11C) acetate positron emission tomography in prostatic carcinoma. New prospects in metabolic imaging]. ( Ackermann, R; Coenen, HH; Hautzel, H; Herzog, H; Krause, BJ; Müller-Gärtner, HW; Müller-Mattheis, V; Roden, W, 2002)
"11C-choline PET was very effective in detecting lymph node metastases in the mediastinum originating from NSCLC, with a sensitivity of 100%."1.31Sensitive detection of mediastinal lymph node metastasis of lung cancer with 11C-choline PET. ( Hara, T; Inagaki, K; Kosaka, N; Morita, T, 2000)
"Betaine was measured from liver tissue by a high-performance liquid chromatographic (HPLC) method developed for this study."1.31A novel method to analyze betaine in chicken liver: effect of dietary betaine and choline supplementation on the hepatic betaine concentration in broiler chicks. ( Kettunen, H; Peuranen, S; Pulliainen, K; Remus, J; Saarinen, MT; Tiihonen, K, 2001)
" There was negative linear correlation between the dosage of carnitine and formation of [(3)H]AFB(1)-DNA adducts in the hepatocytes; however, the partitioning of AFB(1) into cellular compartments was not affected by carnitine."1.31Carnitine alters binding of aflatoxin to DNA and proteins in rat hepatocytes and cell-free systems. ( Sachan, DS; Yatim, AM, 2001)
"To determine whether invasive breast cancer can be distinguished from benign lesions with proton magnetic resonance (MR) spectroscopy ex vivo on the basis of altered cellular chemistry."1.30Fine-needle biopsy specimens of benign breast lesions distinguished from invasive cancer ex vivo with proton MR spectroscopy. ( Barraclough, BH; Barry, PA; Bilous, M; Doran, ST; Gillett, DJ; Lean, CL; Mackinnon, WB; Malycha, PL; Mountford, CE; Russell, P, 1997)
"A sensitive and rapid flow-injection analysis (FIA) of total choline-containing phospholipids (PLs) and a selective FIA method for the class assay of choline-containing PLs combined with preparative HPLC were described."1.29Sensitive flow-injection method with peroxyoxalate chemiluminescence detection combined with preparative high-performance liquid chromatography for determination of choline-containing phospholipids in human serum. ( Akiyama, S; Imai, K; Kuroda, N; Nakashima, K; Wada, M, 1996)
"Choline is a primary degradation product of succinylcholine chloride."1.29Determination of choline in pharmaceutical formulations by reversed-phase high-performance liquid chromatography and postcolumn suppression conductivity detection. ( Chen, S; Soneji, V; Webster, J, 1996)
"Choline was a full agonist for alpha 7, but a hydroxyl group was strongly non-permissive for other receptor subtypes (alpha 1 beta 1 gamma delta, alpha 3 beta 4, alpha 3 beta 2, and alpha 4 beta 2)."1.29An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. ( Bencherif, M; Lippiello, P; Papke, RL, 1996)

Research

Studies (413)

TimeframeStudies, this research(%)All Research%
pre-19905 (1.21)18.7374
1990's28 (6.78)18.2507
2000's166 (40.19)29.6817
2010's207 (50.12)24.3611
2020's7 (1.69)2.80

Authors

AuthorsStudies
Wu, LA1
Yen, RF1
Shih, TT1
Chen, KL1
Wang, J2
Farche, MK1
Fachinetti, NO1
da Silva, LR1
Matos, LA1
Appenzeller, S1
Cendes, F1
Reis, F1
Prades, JM1
Lelonge, Y1
Farizon, B1
Chatard, S1
Prevot-Bitot, N1
Gavid, M1
Sodano, C1
Clauser, P2
Dietzel, M3
Kapetas, P1
Pinker, K2
Helbich, TH2
Gussew, A1
Baltzer, PA3
Karahissarlian, V1
Sargos, P1
Blais, E1
Cazeau, AL1
Fontes, F1
Petitpierre, F1
Rigou, G2
De Vaugelade, C1
Mariey, A1
Hindié, E2
Thomas, L1
Enoki, T1
Jomoto, W1
Yamano, T1
Kotoura, N1
Yap, A1
Hope, TA1
Graves, CE1
Kluijfhout, W1
Shen, WT1
Gosnell, JE1
Sosa, JA1
Roman, SA1
Duh, QY1
Suh, I1
Kanoun, S1
Walker, P1
Vrigneaud, JM1
Depardon, E1
Barbier, V1
Humbert, O1
Moulin, M1
Créhange, G1
Cormier, L1
Loffroy, R1
Brunotte, F2
Cochet, A1
Vadi, SK1
Singh, B1
Basher, RK1
Watts, A1
Sood, AK1
Lal, A1
Kakkar, N1
Singh, SK1
Marcon, M1
Baltzer, PAT1
Padhani, AR1
Lecouvet, FE1
Tunariu, N2
Koh, DM1
De Keyzer, F2
Collins, DJ1
Sala, E2
Fanti, S13
Vargas, HA1
Petralia, G1
Schlemmer, HP2
Tombal, B1
de Bono, J1
Lawrentschuk, N1
Corfield, JM1
Scott, A1
Kim, SJ2
Koo, PJ1
Pak, K1
Kim, IJ1
Kim, K1
Yu, W1
Xu, C2
Li, G2
Hong, W1
Zhou, Z1
Xiao, C1
Zhao, Y1
Cai, Y1
Huang, M1
Jin, J1
Frood, R1
Baren, J1
McDermott, G1
Bottomley, D1
Patel, C1
Scarsbrook, A1
Gao, L1
Xu, W1
Li, T1
Zheng, J1
Chen, G3
Mazaheri, Y1
Shukla-Dave, A1
Goldman, DA1
Moskowitz, CS1
Takeda, T1
Reuter, VE1
Akin, O1
Hricak, H1
Wang, B2
Koo, B1
Huang, LW1
Monbouquette, HG1
Huang, Y2
Lin, Y2
Hu, W1
Ma, C1
Lin, W1
Wang, Z1
Liang, J1
Ye, W1
Zhao, J1
Wu, R1
Aghaghazvini, L1
Pirouzi, P1
Sharifian, H1
Yazdani, N1
Kooraki, S1
Ghadiri, A1
Assadi, M1
Amadou, C1
Bera, G1
Ezziane, M1
Chami, L1
Delbot, T1
Rouxel, A1
Leban, M1
Herve, G1
Menegaux, F1
Leenhardt, L1
Kas, A1
Trésallet, C1
Ghander, C1
Lussey-Lepoutre, C1
Sharma, U2
Agarwal, K1
Hari, S1
Mathur, SR2
Seenu, V2
Parshad, R2
Jagannathan, NR3
Vassiou, K2
Tsougos, I3
Kousi, E3
Vlychou, M1
Athanasiou, E1
Theodorou, K3
Arvanitis, DL1
Fezoulidis, IV1
Wu, W1
Zhang, P1
Wang, X5
Chineah, A1
Lou, M1
Chen, HC1
Chen, YH1
Chen, SL1
Chern, YT1
Tsai, RY1
Hua, MY1
Dost, RJ1
Glaudemans, AW1
Breeuwsma, AJ4
de Jong, IJ7
Hädel, S1
Wirth, C1
Rapp, M1
Gallinat, J1
Schubert, F1
Bittner, DM1
Heinze, HJ1
Kaufmann, J1
Brogsitter, C1
Zöphel, K3
Kotzerke, J3
Castellucci, P9
Picchio, M7
Salamon, N1
Ellingson, BM1
Nagarajan, R2
Gebara, N1
Thomas, A1
Holly, LT1
Zhou, J2
Sha, L1
Li, Y3
Qu, X1
Liu, L2
Chen, H1
An, Z1
Wang, Y4
Sun, C1
Xin, L1
Gambarota, G1
Cudalbu, C1
Mlynárik, V1
Gruetter, R1
Finnsson, J1
Melberg, A1
Raininko, R1
Suppiah, S1
Rahmat, K1
Mohd-Shah, MN1
Azlan, CA1
Tan, LK1
Aziz, YF1
Vijayananthan, A1
Wui, AL1
Yip, CH1
Takeuchi, M1
Matsuzaki, K2
Harada, M2
Passoni, NM1
Suardi, N1
Abdollah, F1
Giovacchini, G3
Messa, C5
Freschi, M1
Montorsi, F1
Briganti, A1
Van den Bergh, L2
Isebaert, S2
Koole, M2
Oyen, R2
Joniau, S2
Lerut, E2
Deroose, CM2
Van Poppel, H2
Haustermans, K2
Svolos, P1
Athanassiou, E1
Arvanitis, D1
Fezoulidis, I2
Hetherington, HP1
Hamid, H1
Kulas, J1
Ling, G1
Bandak, F1
de Lanerolle, NC1
Pan, JW1
Lu, SS1
Kim, HS1
Choi, CG1
Lim, YM1
Kim, EJ1
Kim, DY1
Cho, SH1
Bolan, PJ3
Kjölhede, H1
Ahlgren, G1
Almquist, H1
Liedberg, F1
Lyttkens, K1
Ohlsson, T1
Bratt, O1
Frey, O2
Rothe, J1
Heer, F1
van der Wal, PD1
de Rooij, NF1
Hierlemann, A1
Chang, JH3
Lim Joon, D2
Lee, ST3
Hiew, CY2
Esler, S2
Gong, SJ3
Wada, M3
Clouston, D3
O'Sullivan, R2
Goh, YP2
Tochon-Danguy, H1
Chan, JG1
Bolton, D3
Scott, AM3
Khoo, V3
Davis, ID3
Gajdošík, M1
Chmelík, M2
Just-Kukurová, I1
Bogner, W2
Valkovič, L1
Trattnig, S3
Krššák, M2
Takenaka, S1
Asano, Y1
Shinoda, J1
Nomura, Y1
Yonezawa, S1
Miwa, K1
Yano, H1
Iwama, T1
Poulsen, MH2
Petersen, H2
Høilund-Carlsen, PF2
Jakobsen, JS1
Gerke, O2
Karstoft, J1
Steffansen, SI2
Walter, S2
Novak, J1
Wilson, M1
Macpherson, L2
Arvanitis, TN2
Davies, NP1
Peet, AC2
Baek, HM3
Lee, YJ1
Mama, N1
Ben Abdallah, A1
Hasni, I1
Kadri, K1
Arifa, N1
Ladib, M1
Tlili-Graiess, K1
Kitajima, K1
Murphy, RC1
Nathan, MA1
Froemming, AT1
Hagen, CE1
Takahashi, N1
Kawashima, A1
Sun, LW1
Zhang, HY1
Wu, L1
Shu, S1
Xia, C1
Zheng, JS1
Thörmer, G1
Otto, J1
Horn, LC1
Garnov, N1
Do, M1
Franz, T1
Stolzenburg, JU1
Moche, M1
Kahn, T1
Busse, H1
Chondrogiannis, S1
Marzola, MC3
Ferretti, A1
Grassetto, G1
Maffione, AM1
Rampin, L1
Giammarile, F1
Rubello, D7
Ding, XQ1
Maudsley, AA4
Sabati, M1
Sheriff, S1
Dellani, PR1
Lanfermann, H1
Liang, X1
Tang, G1
Wang, H1
Hu, K1
Tang, X1
Nie, D1
Sun, T2
Huang, T1
Hartenbach, M1
Hartenbach, S1
Bechtloff, W1
Danz, B1
Kraft, K1
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Tomasi, G1
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Cardwell, D1
Komoroski, R1
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Hara, T3
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Suzuki, T1
Kudo, K1
Niino, H1
DAUTERMAN, WC1
MEHROTRA, KN1
HEMSWORTH, BA1
MORRIS, D1
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Ruan, LX1
Zhang, LJ1
Yuan, M1
Shang, DS1
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Simonetti, AW1
Melssen, WJ1
Postma, GJ1
Buydens, LM1
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Ninomiya, H2
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Patsalides, A1
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Poca, MA1
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Clinical Trials (20)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206]12 participants (Anticipated)Observational2020-12-31Not yet recruiting
All-in-One Prostate Cancer Staging With MRI[NCT06071195]400 participants (Anticipated)Observational2021-12-22Recruiting
PRISMA-PET - Primary Staging of Prostate Cancer: A Randomized Controlled Trial Comparing 18F-PSMA-1007 PET/CT to Conventional Imaging[NCT05123300]448 participants (Anticipated)Interventional2021-10-04Recruiting
Two Bed SPECT/CT Versus Planar Bone Scintigraphy in Detection of Osseous Metastases in Patients With Genitourinary Malignancies[NCT05597215]70 participants (Anticipated)Observational2022-12-31Not yet recruiting
Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770]140 participants (Anticipated)Interventional2019-10-10Active, not recruiting
GutHeart: Targeting Gut Microbiota to Treat Heart Failure[NCT02637167]Phase 2150 participants (Anticipated)Interventional2016-03-11Recruiting
Diagnostic and Prognostic Role of 11C-Choline PET/CT and DWI MRI for Response Assessment in Patients Affected by Hepatocellular Carcinoma (HCC) and Candidate to TARE[NCT02519075]14 participants (Actual)Observational2015-04-30Completed
What is the Prognostic Value of ¹¹C-choline PET/CT in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma?[NCT03430635]40 participants (Actual)Observational2010-01-01Completed
A Multi-center, Open-label, Single Arm Phase III Clinical Trial for the Diagnostic Efficacy Assessment and Safety Evaluation by [18F]Florastamin PET/CT Imaging Examination in Patients With Suspected Recurrent or Metastatic Prostate Cancer[NCT05936658]Phase 389 participants (Anticipated)Interventional2023-05-08Recruiting
Metabolic Health in Asian Women and Their Children[NCT01174875]1,247 participants (Actual)Observational2009-06-30Active, not recruiting
WHOLE-BODY DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING (WB-DW-MRI) VS CHOLINE-POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY (CHOLINE- PET/CT) for Selecting Treatments in Recurrent Prostate Cancer[NCT02858128]46 participants (Actual)Observational2014-10-31Completed
F-choline PET in Early Response Assessment for Castration Resistant Prostatic Cancer Treated by Abiraterone Acetate or Enzalutamide[NCT01981707]Phase 2/Phase 312 participants (Actual)Interventional2013-12-31Terminated (stopped due to enrollment default)
Phase III Multicentre Prospective Comparative Study of Detection Rate of 18F-JK-PSMA-7 and of 18F-fluorocholine in Patients With Biochemical Recurrence of Prostate Cancer After Previous Treatment With Curative Intent[NCT05622162]Phase 3106 participants (Anticipated)Interventional2022-11-30Not yet recruiting
A Phase I/II, Open Labeled, Monocentric Study of Direct Intracranial Administration of a Replication Deficient Adeno-associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human ARSA cDNA to Children With Metachromatic Leukodystrophy.[NCT01801709]Phase 1/Phase 25 participants (Anticipated)Interventional2014-06-30Active, not recruiting
Central Nervous System Uptake of Intranasal Glutathione in Parkinson's Disease[NCT02324426]Phase 115 participants (Actual)Interventional2014-12-31Completed
Evaluation of [18F] Fluorocholine PET/CT for Detection of Regional Lymph Node Metastases From Prostate Cancer[NCT00670527]205 participants (Anticipated)Interventional2008-01-31Recruiting
Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity - the MISTY Study[NCT03065140]50 participants (Actual)Interventional2016-09-30Completed
Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458]50 participants (Anticipated)Observational2020-06-01Recruiting
Clinical Value of [18]Fluoroethylcholine Positron-Emission-Tomography Combined With Endorectal Magnetic Resonance Imaging by Software Fusion for Pre-therapeutic Staging of Prostate Cancer[NCT00520546]Phase 344 participants (Actual)Interventional2007-12-31Completed
Evaluation of 11 C-Choline PET-CT for Detection of Hepatocellular Carcinoma[NCT01377220]Phase 230 participants (Anticipated)Interventional2011-06-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Lesion Based Analysis of FEC-PET, Endorectal MRI and Combined FEC-PET/eMRI in All Patients

PET positive lesions (n=128) were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative and positive predictive values were determined. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionlesions (Number)
True positiveFalse positiveTrue negativeFalse negativeTotal trueTotal false
FEC-PET592619247850
Magnetic Resonance Imaging (MRI)402718435870
PET/MRI55837289236

Lesion Based Analysis of FEC-PET, Endorectal MRI and Combined FEC-PET/eMRI in Patients With Gleason Score >6 (3+3)

PET positive lesions in patients with Gleason >6(3+3),n=43 were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative & positive predictive values were determined. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionlesions (Number)
True positiveFalse positiveTrue negativeFalse negativeTotal trueTotal false
FEC-PET27583358
Magnetic Resonance Imaging (MRI)229482617
PET/MRI271114385

Lesion Based Analysis of FEC-PET, Endorectal MRI and Combined FEC-PET/eMRI in Patients With Malignant Lesions >5mm (n=98)

PET positive lesions were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative and positive predictive values were determined without malign lesions <=5mm. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionlesions (Number)
True positiveFalse positiveTrue negativeFalse negativeTotal trueTotal false
FEC-PET48241886632
Magnetic Resonance Imaging (MRI)372616195345
PET/MRI48832108018

Number of Participants With Positive or Negative Results in PET, MRI or PET/MRI for Prostate Cancer Compared to Histological Findings

PET positive lesions were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. At least 1 histological confirmed cancer lesion has to be detected by each of the 3 methods to be patient based true positive. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionparticipants (Number)
True PositiveFalse PositiveTrue NegativeFalse NegativeTotal TrueTotal False
[18F]Fluoroethylcholine Positron-Emission-Tomography (FEC-PET)36101362
Magnetic Resonance Imaging (MRI)2610112711
PositronEmissionTomography/MagneticResonanceImaging (PET/MRI)35012362

Reviews

31 reviews available for choline and Sensitivity and Specificity

ArticleYear
Rationale for Modernising Imaging in Advanced Prostate Cancer.
    European urology focus, 2017, Volume: 3, Issue:2-3

    Topics: Choline; Humans; Magnetic Resonance Imaging; Male; Neoplasm Metastasis; Positron Emission Tomography

2017
Is choline-based PET imaging still relevant in recurrent prostate cancer?
    BJU international, 2017, Volume: 120, Issue:3

    Topics: Aged; Aged, 80 and over; Choline; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Positron Em

2017
Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis.
    World journal of urology, 2018, Volume: 36, Issue:3

    Topics: Acetates; Carbon; Carbon Radioisotopes; Carcinoma, Transitional Cell; Choline; Humans; Likelihood Fu

2018
Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis.
    Medicine, 2018, Volume: 97, Issue:29

    Topics: Carbon Radioisotopes; Choline; Diagnosis, Differential; Glioma; Humans; Necrosis; Neoplasm Recurrenc

2018
18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients.
    European journal of nuclear medicine and molecular imaging, 2013, Volume: 40 Suppl 1

    Topics: Acetates; Carbon; Choline; Humans; Male; Multimodal Imaging; Neoplasm Staging; Positron-Emission Tom

2013
11C-choline PET/CT and PSA kinetics.
    European journal of nuclear medicine and molecular imaging, 2013, Volume: 40 Suppl 1

    Topics: Carbon Radioisotopes; Choline; Humans; Male; Multimodal Imaging; Positron-Emission Tomography; Prost

2013
Magnetic resonance spectroscopy of the breast: current status.
    Magnetic resonance imaging clinics of North America, 2013, Volume: 21, Issue:3

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnetic Resona

2013
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.
    Skeletal radiology, 2014, Volume: 43, Issue:11

    Topics: Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Observer Vari

2014
Novel biomarker for prostate cancer diagnosis by MRS.
    Frontiers in bioscience (Landmark edition), 2014, 06-01, Volume: 19, Issue:7

    Topics: Biomarkers, Tumor; Choline; Citric Acid; Creatine; Humans; Inositol; Magnetic Resonance Spectroscopy

2014
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
    Current pediatric reviews, 2014, Volume: 10, Issue:1

    Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas

2014
Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?
    BioMed research international, 2014, Volume: 2014

    Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Molecu

2014
1H-MRS evaluation of breast lesions by using total choline signal-to-noise ratio as an indicator of malignancy: a meta-analysis.
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:5

    Topics: Breast; Breast Neoplasms; Choline; Diagnosis, Differential; Female; Humans; Proton Magnetic Resonanc

2015
Diagnostic capability of salivary biomarkers in the assessment of head and neck cancer: A systematic review and meta-analysis.
    Oral oncology, 2015, Volume: 51, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Carbocysteine; Choline; Head and Neck Neoplasms; Humans;

2015
Bio-Distribution, Imaging Protocols and Diagnostic Accuracy of PET with Tracers of Lipogenesis in Imaging Prostate Cancer: a Comparison between 11C-Choline, 18FFluoroethylcholine and 18F-Methylcholine.
    Current pharmaceutical design, 2015, Volume: 21, Issue:32

    Topics: Carbon Radioisotopes; Choline; Fluorine Radioisotopes; Humans; Lipogenesis; Male; Neoplasm Metastasi

2015
New Positron-Emission Tomography/Computed Tomography Imaging for Bone Metastases
.
    Clinical journal of oncology nursing, 2016, Volume: 20, Issue:2

    Topics: Bone Neoplasms; Choline; Female; Fluorodeoxyglucose F18; Humans; Male; Neoplasm Metastasis; Neoplasm

2016
Multi-technique imaging of bone metastases: spotlight on PET-CT.
    Clinical radiology, 2016, Volume: 71, Issue:7

    Topics: Bone Neoplasms; Choline; Contrast Media; Evidence-Based Medicine; Fluorodeoxyglucose F18; Humans; Im

2016
Rapidly changing landscape of PET/CT imaging in prostate cancer.
    Current opinion in urology, 2016, Volume: 26, Issue:5

    Topics: Antigens, Surface; Choline; Glutamate Carboxypeptidase II; Humans; Male; Neoplasm Recurrence, Local;

2016
Radiolabeled choline PET/CT before salvage lymphadenectomy dissection: a systematic review and meta-analysis.
    Nuclear medicine communications, 2016, Volume: 37, Issue:12

    Topics: Choline; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Neoplasm Recurrence, Local; Positr

2016
Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer.
    Topics in magnetic resonance imaging : TMRI, 2008, Volume: 19, Issue:6

    Topics: Biomarkers, Tumor; Choline; Citrates; Contrast Media; Creatine; Diagnosis, Differential; Diffusion M

2008
[Magnetic resonance spectroscopy for cerebral imaging].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:6

    Topics: Apoptosis; Aspartic Acid; Asphyxia Neonatorum; Biomarkers, Tumor; Brain; Brain Diseases; Brain Disea

2010
Choline PET/CT for prostate cancer: main clinical applications.
    European journal of radiology, 2011, Volume: 80, Issue:2

    Topics: Choline; Humans; Kinetics; Male; Multimodal Imaging; Neoplasm Staging; Positron-Emission Tomography;

2011
Metabolic positron emission tomography imaging in cancer detection and therapy response.
    Seminars in oncology, 2011, Volume: 38, Issue:1

    Topics: Choline; Drug Monitoring; Fluorodeoxyglucose F18; Humans; Molecular Imaging; Neoplasm Staging; Neopl

2011
Biomarkers in acute coronary syndrome and percutaneous coronary intervention.
    Minerva cardioangiologica, 2011, Volume: 59, Issue:3

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acute Coronary Syndrome; Angioplasty, Balloon, Coron

2011
[Diagnostic relevance of choline-PET / CT in patients with prostate cancer].
    Aktuelle Urologie, 2012, Volume: 43, Issue:1

    Topics: Bone Neoplasms; Carbon Radioisotopes; Choline; Disease Progression; Fluorine Radioisotopes; Humans;

2012
Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions.
    AJR. American journal of roentgenology, 2012, Volume: 198, Issue:1

    Topics: Algorithms; Biomarkers, Tumor; Bone Neoplasms; Choline; Contrast Media; Humans; Image Interpretation

2012
[Choline PET/CT in the diagnosis of primary and recurrent prostate cancer. Are there evidence-based indications?].
    Der Urologe. Ausg. A, 2012, Volume: 51, Issue:6

    Topics: Choline; Clinical Trials as Topic; Evidence-Based Medicine; Humans; Male; Multimodal Imaging; Neopla

2012
MR-spectroscopy at 1.5 tesla and 3 tesla. Useful? A systematic review and meta-analysis.
    European journal of radiology, 2012, Volume: 81 Suppl 1

    Topics: Biomarkers, Tumor; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; Female; Humans; Magnetic

2012
[1H magnetic resonance spectroscopy of the prostate].
    Der Radiologe, 2003, Volume: 43, Issue:6

    Topics: Biopsy; Choline; Citrates; Creatine; Follow-Up Studies; Humans; Imaging, Three-Dimensional; Magnetic

2003
In vivo proton magnetic resonance spectroscopy of breast lesions: an update.
    Breast cancer research and treatment, 2007, Volume: 104, Issue:3

    Topics: Breast; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Choline; Disease Progression; False

2007
Is there a role for positron emission tomography imaging in the early evaluation of prostate cancer relapse?
    Prostate cancer and prostatic diseases, 2008, Volume: 11, Issue:2

    Topics: Adenocarcinoma; Carbon Radioisotopes; Choline; Clinical Trials as Topic; Humans; Lymphatic Metastasi

2008
[Alzheimer's disease and magnetic resonance spectroscopy of the hippocampus].
    Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine;

2001

Trials

44 trials available for choline and Sensitivity and Specificity

ArticleYear
Proton magnetic resonance spectroscopy of human cervical spondylosis at 3T.
    Spinal cord, 2013, Volume: 51, Issue:7

    Topics: Aspartic Acid; Biomarkers; Choline; Creatine; Humans; Magnetic Resonance Imaging; Magnetic Resonance

2013
Diffusion-weighted MRI, 11C-choline PET and 18F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma.
    European radiology, 2014, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Aged; Biopsy; Carbon Radioisotopes; Choline; Diffusion Magnetic Resonance Imaging; F

2014
Combined PET/MRI improves diagnostic accuracy in patients with prostate cancer: a prospective diagnostic trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jun-15, Volume: 20, Issue:12

    Topics: Aged; Choline; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal

2014
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.
    International journal of radiation oncology, biology, physics, 2014, Oct-01, Volume: 90, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea

2014
BAY 1075553 PET-CT for Staging and Restaging Prostate Cancer Patients: Comparison with [18F] Fluorocholine PET-CT (Phase I Study).
    Molecular imaging and biology, 2015, Volume: 17, Issue:3

    Topics: Aged; Aged, 80 and over; Bone Marrow; Choline; Fluorodeoxyglucose F18; Glutarates; Humans; Lymphatic

2015
The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis.
    European journal of radiology, 2015, Volume: 84, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Choli

2015
Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain: a (1)H MRS study of healthy subjects.
    Magma (New York, N.Y.), 2015, Volume: 28, Issue:5

    Topics: Administration, Oral; Adult; Alcohol Drinking; Brain; Choline; Creatine; Dose-Response Relationship,

2015
Whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) vs choline-positron emission tomography-computed tomography (choline-PET/CT) for selecting treatments in recurrent prostate cancer.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2017, Volume: 19, Issue:5

    Topics: Aged; Aged, 80 and over; Choline; Diffusion Magnetic Resonance Imaging; Humans; Male; Middle Aged; N

2017
MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial.
    Journal of magnetic resonance imaging : JMRI, 2017, Volume: 46, Issue:1

    Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Breast Neoplasms; Choline; Early Detection of Cancer; Fe

2017
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
    Dementia and geriatric cognitive disorders, 2008, Volume: 26, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea

2008
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease.
    Dementia and geriatric cognitive disorders, 2008, Volume: 26, Issue:1

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differenti

2008
Monitoring of treatment response after chemoradiotherapy for head and neck cancer using in vivo 1H MR spectroscopy.
    European radiology, 2010, Volume: 20, Issue:1

    Topics: Biomarkers, Tumor; Chemotherapy, Adjuvant; Choline; Diagnosis, Computer-Assisted; Female; Head and N

2010
Dynamic MRI and CAD vs. choline MRS: where is the detection level for a lesion characterisation in prostate cancer?
    International journal of radiation biology, 2009, Volume: 85, Issue:9

    Topics: Aged; Biopsy; Choline; Diagnosis, Computer-Assisted; Humans; Magnetic Resonance Imaging; Magnetic Re

2009
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis.
    Archives italiennes de biologie, 2009, Volume: 147, Issue:3

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusio

2009
Detection of bronchioloalveolar cancer by means of PET/CT and 18F-fluorocholine, and comparison with 18F-fluorodeoxyglucose.
    Nuclear medicine communications, 2010, Volume: 31, Issue:5

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aged; Aged, 80 and over; Biological Transport; Choline; Female;

2010
Preoperative detection of prostate cancer: a comparison with 11C-choline PET, 18F-fluorodeoxyglucose PET and MR imaging.
    Journal of magnetic resonance imaging : JMRI, 2010, Volume: 31, Issue:5

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Humans; Magnetic Resona

2010
¹⁸F-Fluoromethylcholine (FCH) PET imaging in patients with castration-resistant prostate cancer: prospective comparison with standard imaging.
    European journal of nuclear medicine and molecular imaging, 2011, Volume: 38, Issue:1

    Topics: Aged; Aged, 80 and over; Choline; Follow-Up Studies; Humans; Male; Middle Aged; Orchiectomy; Positro

2011
Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy.
    Neurology, 2010, Nov-23, Volume: 75, Issue:21

    Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Choline; Cognition; Creatine; Disease Progressio

2010
Prostate cancer: 1HMRS-DCEMR at 3T versus [(18)F]choline PET/CT in the detection of local prostate cancer recurrence in men with biochemical progression after radical retropubic prostatectomy (RRP).
    European journal of radiology, 2012, Volume: 81, Issue:4

    Topics: Aged; Choline; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Age

2012
Comparison of (11)C-choline PET/CT and enhanced CT in the evaluation of patients with pulmonary abnormalities and locoregional lymph node involvement in lung cancer.
    Clinical lung cancer, 2012, Volume: 13, Issue:4

    Topics: Adult; Aged; Carbon Radioisotopes; Choline; Contrast Media; Female; Humans; Lung Neoplasms; Lymph No

2012
The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy.
    Nuclear medicine communications, 2013, Volume: 34, Issue:2

    Topics: Adenoma, Liver Cell; Adult; Aged; Choline; Diagnosis, Differential; Female; Focal Nodular Hyperplasi

2013
Visualisation of bladder cancer using (11)C-choline PET: first clinical experience.
    European journal of nuclear medicine and molecular imaging, 2002, Volume: 29, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Squamous Cell; Carcinosarcoma; Chol

2002
Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 2002, Volume: 48, Issue:6

    Topics: Aspartic Acid; Brain; Brain Chemistry; Choline; Embryonic and Fetal Development; Female; Gestational

2002
Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.
    NMR in biomedicine, 2003, Volume: 16, Issue:1

    Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Dipeptides; Female; Glutamic Acid

2003
A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer.
    Nuclear medicine communications, 2003, Volume: 24, Issue:4

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Choline

2003
11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer.
    European urology, 2003, Volume: 44, Issue:1

    Topics: Aftercare; Aged; Aged, 80 and over; Biopsy, Needle; Brachytherapy; Choline; Cohort Studies; Humans;

2003
11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer.
    European urology, 2003, Volume: 44, Issue:1

    Topics: Aftercare; Aged; Aged, 80 and over; Biopsy, Needle; Brachytherapy; Choline; Cohort Studies; Humans;

2003
11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer.
    European urology, 2003, Volume: 44, Issue:1

    Topics: Aftercare; Aged; Aged, 80 and over; Biopsy, Needle; Brachytherapy; Choline; Cohort Studies; Humans;

2003
11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer.
    European urology, 2003, Volume: 44, Issue:1

    Topics: Aftercare; Aged; Aged, 80 and over; Biopsy, Needle; Brachytherapy; Choline; Cohort Studies; Humans;

2003
Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis.
    Magnetic resonance in medicine, 2003, Volume: 50, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Choline; Corpus Callosum; Creatine; Diffusion; Female; Humans; Magnetic

2003
Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003, Volume: 44, Issue:7

    Topics: Adenocarcinoma; Adult; Aged; Carbon Radioisotopes; Carcinoma, Squamous Cell; Carcinosarcoma; Choline

2003
The role of relaxation time corrections for the evaluation of long and short echo time 1H MR spectra of the hippocampus by NUMARIS and LCModel techniques.
    Magma (New York, N.Y.), 2003, Volume: 16, Issue:3

    Topics: Adult; Algorithms; Aspartic Acid; Brain Mapping; Choline; Creatine; Diagnosis, Computer-Assisted; Ep

2003
MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms.
    Journal of Zhejiang University. Science, 2004, Volume: 5, Issue:2

    Topics: Aged; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Humans; Magnetic Resonance Spec

2004
Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors.
    European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone Neoplasms; Brain Neoplasms; Carbon Radioisotopes; C

2004
Diagnosis of tumor in the nasal cavity and paranasal sinuses with [11C]choline PET: comparative study with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) PET.
    Annals of nuclear medicine, 2004, Volume: 18, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Female; Fluorodeoxyglucose F18; Human

2004
Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings.
    Neuroradiology, 2004, Volume: 46, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choli

2004
Magnetic resonance spectroscopic determination of a neuronal and axonal marker in white matter predicts reversibility of deficits in secondary normal pressure hydrocephalus.
    Journal of neurology, neurosurgery, and psychiatry, 2004, Volume: 75, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Humans; Hydrocephalus, Normal Pre

2004
Proton T2 relaxation of cerebral metabolites of normal human brain over large TE range.
    NMR in biomedicine, 2005, Volume: 18, Issue:1

    Topics: Adult; Algorithms; Astrocytes; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance S

2005
Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2006, Volume: 47, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Choline; Humans; Image Enhancement; Image Interpretation, Computer-A

2006
Improved two-dimensional J-resolved spectroscopy.
    NMR in biomedicine, 2006, Volume: 19, Issue:2

    Topics: Adult; Algorithms; Choline; Humans; Magnetic Resonance Spectroscopy; Nerve Tissue Proteins; Neurotra

2006
Contrast/Noise ratio on conventional MRI and choline/creatine ratio on proton MRI spectroscopy accurately discriminate low-grade from high-grade cerebral gliomas.
    Academic radiology, 2006, Volume: 13, Issue:6

    Topics: Adolescent; Adult; Aged; Algorithms; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Fe

2006
Value of 11C-choline PET and contrast-enhanced CT for staging of bladder cancer: correlation with histopathologic findings.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2006, Volume: 47, Issue:6

    Topics: Aged; Aged, 80 and over; Choline; Contrast Media; Female; Humans; Male; Middle Aged; Neoplasm Stagin

2006
[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas].
    Arquivos de neuro-psiquiatria, 2007, Volume: 65, Issue:2A

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Chol

2007
Detection of bone metastases in patients with prostate cancer by 18F fluorocholine and 18F fluoride PET-CT: a comparative study.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:10

    Topics: Adult; Bone Neoplasms; Choline; Fluorine Radioisotopes; Humans; Male; Positron-Emission Tomography;

2008
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
    Magnetic resonance in medicine, 2000, Volume: 44, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D

2000
Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure.
    Circulation, 2001, Jun-12, Volume: 103, Issue:23

    Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Female; Follow-Up Studies

2001
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke.
    Stroke, 2001, Dec-01, Volume: 32, Issue:12

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female;

2001

Other Studies

338 other studies available for choline and Sensitivity and Specificity

ArticleYear
Diagnostic Performance of Proton Magnetic Resonance Spectroscopy and 18F-Fluorocholine PET to Differentiate Benign From Malignant Breast Lesions.
    Clinical nuclear medicine, 2021, Nov-01, Volume: 46, Issue:11

    Topics: Breast Neoplasms; Choline; Female; Humans; Positron-Emission Tomography; Proton Magnetic Resonance S

2021
Revisiting the use of proton magnetic resonance spectroscopy in distinguishing between primary and secondary malignant tumors of the central nervous system.
    The neuroradiology journal, 2022, Volume: 35, Issue:5

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Proton M

2022
Positive predictive values of ultrasound-guided fine-needle aspiration with parathyroid hormone assay and Tc-99m sestamibi scintigraphy in sporadic primary hyperparathyroidism.
    European annals of otorhinolaryngology, head and neck diseases, 2023, Volume: 140, Issue:1

    Topics: Biopsy, Fine-Needle; Choline; Humans; Hyperparathyroidism, Primary; Middle Aged; Parathyroid Hormone

2023
Clinical relevance of total choline (tCho) quantification in suspicious lesions on multiparametric breast MRI.
    European radiology, 2020, Volume: 30, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Diseases; Breast Neoplasms; Carcinoma, Ductal, Breast

2020
Diagnostic performance of imaging techniques for detecting of local recurrence after prostate brachytherapy.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2020, Volume: 24, Issue:4

    Topics: Aged; Biopsy; Brachytherapy; Choline; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplas

2020
[Influences of Tumor Volume and FWHM of the Water Peak and T
    Nihon Hoshasen Gijutsu Gakkai zasshi, 2021, Volume: 77, Issue:4

    Topics: Breast Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Prot

2021
A cost-utility analysis of 18F-fluorocholine-positron emission tomography imaging for localizing primary hyperparathyroidism in the United States.
    Surgery, 2022, Volume: 171, Issue:1

    Topics: Choline; Cost-Benefit Analysis; Fluorine Radioisotopes; Four-Dimensional Computed Tomography; Humans

2022
    International journal of radiation oncology, biology, physics, 2017, 04-01, Volume: 97, Issue:5

    Topics: Aged; Biopsy; Choline; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle

2017
18F-Fluorocholine PET/CT Complementing the Role of Dynamic Contrast-Enhanced MRI for Providing Comprehensive Diagnostic Workup in Prostate Cancer Patients With Suspected Relapse Following Radical Prostatectomy.
    Clinical nuclear medicine, 2017, Volume: 42, Issue:8

    Topics: Aged; Choline; Contrast Media; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Stagi

2017
A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy.
    European journal of radiology, 2017, Volume: 92

    Topics: Algorithms; Area Under Curve; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Imaging;

2017
Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients.
    Journal of pharmaceutical and biomedical analysis, 2018, Apr-15, Volume: 152

    Topics: Aged; Betaine; Choline; Chromatography, High Pressure Liquid; Female; Humans; Male; Methylamines; Pl

2018
Diagnostic performance of a streamlined
    Clinical radiology, 2018, Volume: 73, Issue:7

    Topics: Aged; Aged, 80 and over; Choline; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Positron Em

2018
Characterization of prostate cancer with MR spectroscopic imaging and diffusion-weighted imaging at 3 Tesla.
    Magnetic resonance imaging, 2019, Volume: 55

    Topics: Adult; Aged; Area Under Curve; Biopsy; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Huma

2019
Microbiosensor fabrication by polydimethylsiloxane stamping for combined sensing of glucose and choline.
    The Analyst, 2018, Oct-08, Volume: 143, Issue:20

    Topics: Alcohol Oxidoreductases; Biosensing Techniques; Choline; Dimethylpolysiloxanes; Electrochemical Tech

2018
Diffusion Kurtosis at 3.0T as an in vivo Imaging Marker for Breast Cancer Characterization: Correlation With Prognostic Factors.
    Journal of magnetic resonance imaging : JMRI, 2019, Volume: 49, Issue:3

    Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Diffusion Magnetic Resonance Imaging; Diffusion Tens

2019
3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules.
    Archives of endocrinology and metabolism, 2018, Volume: 62, Issue:5

    Topics: Adult; Carcinoma; Choline; Creatine; Female; Humans; Male; Middle Aged; Prospective Studies; Proton

2018
18F-Fluorocholine PET/CT and Parathyroid 4D Computed Tomography for Primary Hyperparathyroidism: The Challenge of Reoperative Patients.
    World journal of surgery, 2019, Volume: 43, Issue:5

    Topics: Adult; Aged; Choline; Female; Four-Dimensional Computed Tomography; Humans; Hyperparathyroidism, Pri

2019
Role of diffusion weighted imaging and magnetic resonance spectroscopy in breast cancer patients with indeterminate dynamic contrast enhanced magnetic resonance imaging findings.
    Magnetic resonance imaging, 2019, Volume: 61

    Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Contrast Media; Diffusion Magnetic Resonance Imaging

2019
Application value of 3T ¹H-magnetic resonance spectroscopy in diagnosing breast tumors.
    Acta radiologica (Stockholm, Sweden : 1987), 2013, Volume: 54, Issue:4

    Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Female; Humans; Ima

2013
Usefulness of (1) H-MRS in differentiating bilirubin encephalopathy from severe hyperbilirubinemia in neonates.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 38, Issue:3

    Topics: Aspartic Acid; Biomarkers; Choline; Creatinine; Diagnosis, Differential; Female; Humans; Hyperbiliru

2013
Preparation of highly conjugated water-dispersible graphene-butyric acid for the enhancement of electron transfer within polyamic acid-benzoxazole: potential applications in electrochemical sensing.
    Biosensors & bioelectronics, 2013, Aug-15, Volume: 46

    Topics: Benzene Derivatives; Benzoxazoles; Biosensing Techniques; Butyric Acid; Catalysis; Choline; Electroc

2013
Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer.
    European journal of nuclear medicine and molecular imaging, 2013, Volume: 40 Suppl 1

    Topics: Androgen Antagonists; Androgens; Choline; Humans; Male; Multimodal Imaging; Neoplasm Recurrence, Loc

2013
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 38, Issue:6

    Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus;

2013
Association of 1H-MR spectroscopy and cerebrospinal fluid biomarkers in Alzheimer's disease: diverging behavior at three different brain regions.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:1

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Case-Control Studies; Cho

2013
Metabolite differences in the lenticular nucleus in type 2 diabetes mellitus shown by proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2013, Volume: 34, Issue:9

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Diabetes Mel

2013
Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.
    Magma (New York, N.Y.), 2013, Volume: 26, Issue:6

    Topics: Animals; Brain; Choline; Creatine; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; Male; P

2013
¹H-MR spectroscopy of adult-onset autosomal dominant leukodystrophy with autonomic symptoms.
    Neuroradiology, 2013, Volume: 55, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Autonomic Nervous System Diseases; Biomarkers; Brain; Choline; Creatine;

2013
Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI.
    Clinical radiology, 2013, Volume: 68, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Early

2013
Preliminary observations and clinical value of lipid peak in high-grade uterine sarcomas using in vivo proton MR spectroscopy.
    European radiology, 2013, Volume: 23, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Choline; Female; Humans; Leiomyoma; Lipids; Magnetic Resonance Spect

2013
Utility of [11C]choline PET/CT in guiding lesion-targeted salvage therapies in patients with prostate cancer recurrence localized to a single lymph node at imaging: results from a pathologically validated series.
    Urologic oncology, 2014, Volume: 32, Issue:1

    Topics: Aged; Androgen Antagonists; Carbon Radioisotopes; Choline; Humans; Lymph Node Excision; Lymph Nodes;

2014
Does 11C-choline PET-CT contribute to multiparametric MRI for prostate cancer localisation?
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2013, Volume: 189, Issue:9

    Topics: Aged; Carbon Radioisotopes; Choline; Humans; Image Enhancement; Image Interpretation, Computer-Assis

2013
The contribution of diffusion tensor imaging and magnetic resonance spectroscopy for the differentiation of breast lesions at 3T.
    Acta radiologica (Stockholm, Sweden : 1987), 2014, Volume: 55, Issue:1

    Topics: Adult; Aged; Anisotropy; Breast Diseases; Choline; Contrast Media; Diagnosis, Differential; Diffusio

2014
MRSI of the medial temporal lobe at 7 T in explosive blast mild traumatic brain injury.
    Magnetic resonance in medicine, 2014, Volume: 71, Issue:4

    Topics: Adult; Aspartic Acid; Biomarkers; Blast Injuries; Brain Injuries; Choline; Creatine; Explosions; Fem

2014
Utility of proton MR spectroscopy for differentiating typical and atypical primary central nervous system lymphomas from tumefactive demyelinating lesions.
    AJNR. American journal of neuroradiology, 2014, Volume: 35, Issue:2

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Demyelinating Diseases; Diagnosis, Differential

2014
¹⁸F-fluorocholine PET/CT compared with extended pelvic lymph node dissection in high-risk prostate cancer.
    World journal of urology, 2014, Volume: 32, Issue:4

    Topics: Aged; Biomarkers, Tumor; Choline; Cohort Studies; Fluorine Radioisotopes; Humans; Lymph Node Excisio

2014
Multisite monitoring of choline using biosensor microprobe arrays in combination with CMOS circuitry.
    Biomedizinische Technik. Biomedical engineering, 2014, Volume: 59, Issue:4

    Topics: Animals; Biosensing Techniques; Brain; Choline; Conductometry; Electrodes, Implanted; Equipment Desi

2014
In vivo relaxation behavior of liver compounds at 7 Tesla, measured by single-voxel proton MR spectroscopy.
    Journal of magnetic resonance imaging : JMRI, 2014, Volume: 40, Issue:6

    Topics: Adult; Body Water; Choline; Female; Humans; Lipids; Liver; Magnetic Resonance Imaging; Male; Proton

2014
Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis.
    Neurologia medico-chirurgica, 2014, Volume: 54, Issue:4

    Topics: Adult; Aged; Area Under Curve; Brain; Brain Neoplasms; Carbon Isotopes; Choline; Combined Modality T

2014
Spine metastases in prostate cancer: comparison of technetium-99m-MDP whole-body bone scintigraphy, [(18) F]choline positron emission tomography(PET)/computed tomography (CT) and [(18) F]NaF PET/CT.
    BJU international, 2014, Volume: 114, Issue:6

    Topics: Aged; Aged, 80 and over; Choline; Humans; Male; Multimodal Imaging; Positron-Emission Tomography; Pr

2014
Clinical protocols for ³¹P MRS of the brain and their use in evaluating optic pathway gliomas in children.
    European journal of radiology, 2014, Volume: 83, Issue:2

    Topics: Adult; Analysis of Variance; Biomarkers, Tumor; Brain; Child, Preschool; Choline; Female; Glioma; Hu

2014
Feasibility of MR spectroscopy for characterizing malignant breast lesions using a clinical 3-T scanner.
    Breast cancer (Tokyo, Japan), 2015, Volume: 22, Issue:5

    Topics: Adult; Aged; Breast Neoplasms; Choline; False Negative Reactions; Feasibility Studies; Female; Human

2015
MR imaging of intracranial hemangiopericytomas.
    Journal of neuroradiology = Journal de neuroradiologie, 2014, Volume: 41, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatine; Female; Hema

2014
Detection of recurrent prostate cancer after radical prostatectomy: comparison of 11C-choline PET/CT with pelvic multiparametric MR imaging with endorectal coil.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Area Under Curve; Carbon Radioisotopes; Choline; Humans; Image Processing,

2014
(1)H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis.
    Journal of dairy science, 2014, Volume: 97, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Blood Glucose; Cattle; Cattle Diseases; Chol

2014
Non-invasive estimation of prostate cancer aggressiveness using diffusion-weighted MRI and 3D proton MR spectroscopy at 3.0 T.
    Acta radiologica (Stockholm, Sweden : 1987), 2015, Volume: 56, Issue:1

    Topics: Aged; Biomarkers, Tumor; Choline; Diffusion Magnetic Resonance Imaging; Humans; Image Interpretation

2015
Is the detection rate of 18F-choline PET/CT influenced by androgen-deprivation therapy?
    European journal of nuclear medicine and molecular imaging, 2014, Volume: 41, Issue:7

    Topics: Aged; Aged, 80 and over; Androgens; Choline; Humans; Image Interpretation, Computer-Assisted; Male;

2014
Reproducibility and reliability of short-TE whole-brain MR spectroscopic imaging of human brain at 3T.
    Magnetic resonance in medicine, 2015, Volume: 73, Issue:3

    Topics: Adult; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans

2015
Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014, Volume: 90

    Topics: Animals; Bacterial Infections; Cell Line, Tumor; Choline; Diagnosis, Differential; Female; Fibrosarc

2014
Hyperpolarized choline as an MR imaging molecular probe: feasibility of in vivo imaging in a rat model.
    Journal of magnetic resonance imaging : JMRI, 2015, Volume: 41, Issue:4

    Topics: Animals; Carbon Isotopes; Choline; Feasibility Studies; Image Interpretation, Computer-Assisted; Mag

2015
Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:4

    Topics: Acetylcarnitine; Adolescent; Adult; Africa, Western; Aged; Aged, 80 and over; alpha-Fetoproteins; Bi

2014
Multiparametric 3T MRI in the evaluation of intraglandular prostate cancer: correlation with histopathology.
    Journal of medical imaging and radiation oncology, 2014, Volume: 58, Issue:4

    Topics: Adult; Aged; Biomarkers, Tumor; Choline; Creatine; Humans; Image Interpretation, Computer-Assisted;

2014
Technical Note: evaluation of the uncertainties in (choline + creatine)/citrate ratios measured by proton MR spectroscopic imaging in patients suspicious for prostate cancer.
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2014, Volume: 186, Issue:7

    Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Choline; Citric Acid; Creatine; Humans; Magnetic Resonan

2014
Delineation of gliomas using radial metabolite indexing.
    NMR in biomedicine, 2014, Volume: 27, Issue:9

    Topics: Algorithms; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Diagnosis, Computer-Assisted

2014
Minimizing lipid signal bleed in brain (1) H chemical shift imaging by post-acquisition grid shifting.
    Magnetic resonance in medicine, 2015, Volume: 74, Issue:2

    Topics: Adult; Algorithms; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Lipid Metabol

2015
Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults.
    Magma (New York, N.Y.), 2015, Volume: 28, Issue:3

    Topics: Aged; Aspartic Acid; Basal Ganglia; Choline; Creatine; Female; Humans; Image Interpretation, Compute

2015
Brain MRI and MR Spectroscopy Findings in Children with Nutritional Vitamin B12 Deficiency.
    Clinical neuroradiology, 2016, Volume: 26, Issue:2

    Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Choline; Creatine; Female; Humans; Infant; Magne

2016
Joint parametric reconstruction and motion correction framework for dynamic PET data.
    Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2014, Volume: 17, Issue:Pt 1

    Topics: Artifacts; Brain; Choline; Computer Simulation; Humans; Image Enhancement; Image Interpretation, Com

2014
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
    Journal of internal medicine, 2015, Volume: 277, Issue:6

    Topics: Aged; Betaine; Biomarkers; Choline; Chronic Disease; Female; Heart Failure; Humans; Intestinal Mucos

2015
Comparative effectiveness of [(18) F]-fluorocholine PET-CT and pelvic MRI with diffusion-weighted imaging for staging in patients with high-risk prostate cancer.
    The Prostate, 2015, Feb-15, Volume: 75, Issue:3

    Topics: Aged; Choline; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neopla

2015
Biosynthetic labeling and two-color imaging of phospholipids in cells.
    Chembiochem : a European journal of chemical biology, 2015, Feb-09, Volume: 16, Issue:3

    Topics: Animals; Azides; Choline; Click Chemistry; Fluorescent Dyes; Mice; Molecular Imaging; Molecular Stru

2015
Comparison between conventional imaging (abdominal-pelvic computed tomography and bone scan) and [(18)F]choline positron emission tomography/computed tomography imaging for the initial staging of patients with intermediate- tohigh-risk prostate cancer: A
    Scandinavian journal of urology, 2015, Volume: 49, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Bone Neoplasms; Choline; Fluorine Radioisotopes; Humans; Lymph Nod

2015
Comparison of [(11)C]choline Positron Emission Tomography With T2- and Diffusion-Weighted Magnetic Resonance Imaging for Delineating Malignant Intraprostatic Lesions.
    International journal of radiation oncology, biology, physics, 2015, Jun-01, Volume: 92, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Carbon Radioisotopes; Choline; Diffusion Magnetic Resonance Imagi

2015
Machine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy.
    The neuroradiology journal, 2015, Volume: 28, Issue:2

    Topics: Algorithms; Artificial Intelligence; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Cre

2015
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu

2015
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu

2015
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu

2015
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu

2015
Improved Diagnostic Accuracy in Characterization of Adnexal Masses by Detection of Choline Peak Using 1H MR Spectroscopy in Comparison to Internal Reference at 3 Tesla.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:12

    Topics: Adnexal Diseases; Adolescent; Adult; Aged; Biomarkers, Tumor; Choline; Female; Follow-Up Studies; Hu

2015
Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients.
    Nuklearmedizin. Nuclear medicine, 2015, Volume: 54, Issue:5

    Topics: Aged; Choline; Comorbidity; Humans; Incidence; Incidental Findings; Lung Neoplasms; Male; Multimodal

2015
Single-voxel (1)H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility.
    NMR in biomedicine, 2015, Volume: 28, Issue:10

    Topics: Adult; Aspartic Acid; Choline; Creatine; Feasibility Studies; Female; Glutamic Acid; Glutamine; Hipp

2015
Diagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors.
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2018, Volume: 62, Issue:2

    Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Human

2018
Diffusion-Weighted Imaging-guided MR Spectroscopy in Breast Lesions using Readout-Segmented Echo-Planar Imaging.
    European radiology, 2016, Volume: 26, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobu

2016
Index lesion characterization by (11)C-Choline PET/CT and Apparent Diffusion Coefficient parameters at 3 Tesla MRI in primary prostate carcinoma.
    The Prostate, 2016, Volume: 76, Issue:1

    Topics: Aged; Biopsy; Carbon Radioisotopes; Carcinoma; Choline; Comparative Effectiveness Research; Diffusio

2016
Comparison between magnetic resonance spectroscopy and diffusion weighted imaging in the evaluation of gliomas response after treatment.
    European journal of radiology, 2015, Volume: 84, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Diffusion Magnetic Resonanc

2015
Fluorescence Ratiometric Assay Strategy for Chemical Transmitter of Living Cells Using H2O2-Sensitive Conjugated Polymers.
    ACS applied materials & interfaces, 2015, Nov-04, Volume: 7, Issue:43

    Topics: Acetylcholine; Biosensing Techniques; Cell Line, Tumor; Choline; Fluorescence Resonance Energy Trans

2015
Detection of recurrent prostate cancer lesions before salvage lymphadenectomy is more accurate with (68)Ga-PSMA-HBED-CC than with (18)F-Fluoroethylcholine PET/CT.
    European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:8

    Topics: Aged; Choline; Edetic Acid; Gallium Isotopes; Gallium Radioisotopes; Humans; Lymph Node Excision; Ma

2016
Have we overcome choline PET/CT for early detection of prostate cancer recurrence?
    Nuclear medicine communications, 2016, Volume: 37, Issue:6

    Topics: Biomarkers, Tumor; Choline; Early Detection of Cancer; Edetic Acid; Evidence-Based Medicine; Gallium

2016
Role of choline PET/CT in evaluation of primary and secondary hyperparathyroidism.
    Nuclear medicine communications, 2016, Volume: 37, Issue:6

    Topics: Choline; Diagnosis, Differential; Humans; Hyperparathyroidism, Primary; Hyperparathyroidism, Seconda

2016
18F-fluorocholine versus 18F-fluorodeoxyglucose for PET/CT imaging in patients with suspected relapsing or progressive multiple myeloma: a pilot study.
    European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:11

    Topics: Aged; Aged, 80 and over; Choline; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Male;

2016
Multiparametric breast MRI with 3T: Effectivity of combination of contrast enhanced MRI, DWI and 1H single voxel spectroscopy in differentiation of Breast tumors.
    European journal of radiology, 2016, Volume: 85, Issue:5

    Topics: Adolescent; Adult; Aged; Biopsy; Breast; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Diffe

2016
(11)C-Choline PET/CT for restaging prostate cancer. Results from 4,426 scans in a single-centre patient series.
    European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:11

    Topics: Aged; Aged, 80 and over; Choline; Disease-Free Survival; Feasibility Studies; Humans; Italy; Lymphat

2016
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
    Neuroradiology, 2016, Volume: 58, Issue:10

    Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child,

2016
Characterization of the response of taurine protons to PRESS at 9.4 T for Resolving choline and Determining taurine T2.
    NMR in biomedicine, 2016, Volume: 29, Issue:10

    Topics: Algorithms; Animals; Brain Chemistry; Choline; Female; Molecular Imaging; Proton Magnetic Resonance

2016
Preclinical acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [(18)F]fluorocholine in mice.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2016, Volume: 116

    Topics: Absorption, Radiation; Animals; Choline; Drug Evaluation, Preclinical; Humans; Male; Metabolic Clear

2016
Diagnostic value of 3.0T (1)H MRS with choline-containing compounds ratio (∆CCC) in primary malignant hepatic tumors.
    Cancer imaging : the official publication of the International Cancer Imaging Society, 2016, Aug-22, Volume: 16, Issue:1

    Topics: Adult; Aged; Case-Control Studies; Choline; Female; Humans; Liver Neoplasms; Magnetic Resonance Imag

2016
Comparison of
    European journal of nuclear medicine and molecular imaging, 2017, Volume: 44, Issue:1

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Choline; Edetic Acid; Gallium Isotopes; Gallium Radioisotop

2017
Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Animals; Brain; Cell Line, Tumor; Choline; Diagnosis, Differential; Disease Models, Animal; Female;

2016
Absolute oral bioavailability of fenofibric acid and choline fenofibrate in rats determined by ultra-performance liquid chromatography tandem mass spectrometry.
    Biomedical chromatography : BMC, 2017, Volume: 31, Issue:4

    Topics: Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Choline; Chroma

2017
Accelerated Echo Planer J-resolved Spectroscopic Imaging of Putamen and Thalamus in Obstructive Sleep Apnea.
    Scientific reports, 2016, 09-06, Volume: 6

    Topics: Adult; Biomarkers; Case-Control Studies; Choline; Echo-Planar Imaging; Female; Humans; Male; Middle

2016
    AJR. American journal of roentgenology, 2016, Volume: 207, Issue:6

    Topics: Aged; Choline; Humans; Image-Guided Biopsy; Magnetic Resonance Imaging, Interventional; Male; Middle

2016
Prospective associations of maternal betaine status with offspring weight and body composition at birth: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study.
    The American journal of clinical nutrition, 2016, Volume: 104, Issue:5

    Topics: Adipose Tissue; Adolescent; Adult; Betaine; Birth Weight; Body Composition; Body Mass Index; Choline

2016
    La Radiologia medica, 2017, Volume: 122, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Body Water; Breast; Breast Neoplasms; Carcinoma

2017
When are metabolic ratios superior to absolute quantification? A statistical analysis.
    NMR in biomedicine, 2017, Volume: 30, Issue:7

    Topics: Adult; Algorithms; Aspartic Acid; Biomarkers; Brain; Brain Injuries; Choline; Data Interpretation, S

2017
Prostate biopsy guided by 18F-fluorocholine PET in men with persistently elevated PSA levels.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:8

    Topics: Aged; Biopsy, Needle; Choline; False Negative Reactions; Humans; Male; Middle Aged; Positron-Emissio

2008
Choline as a biomarker for cell proliferation: do the results from proton MR spectroscopy show difference between HER2/neu positive and negative breast cancers?
    International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5

    Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Choline; Female; Humans; Magne

2008
Effect of paramagnetic manganese cations on (1)H MRS of the brain.
    NMR in biomedicine, 2008, Volume: 21, Issue:10

    Topics: Animals; Aspartic Acid; Brain; Cations; Choline; Creatine; Electron Spin Resonance Spectroscopy; Mal

2008
New observations concerning the interpretation of magnetic resonance spectroscopy of meningioma.
    European radiology, 2008, Volume: 18, Issue:12

    Topics: Adult; Aged; Biomarkers, Tumor; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy;

2008
[(11)C]Choline positron emission tomography/computed tomography for staging and restaging of patients with advanced prostate cancer.
    Nuclear medicine and biology, 2008, Volume: 35, Issue:6

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Carbon Radioisotopes; Choline; Humans; Male; Middle Aged; N

2008
Combined 3T diffusion tensor tractography and 1H-MR spectroscopy in motor neuron disease.
    AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:9

    Topics: Adult; Aged; Anisotropy; Aspartic Acid; Brain; Bulbo-Spinal Atrophy, X-Linked; Choline; Diagnosis, D

2008
Spectrum separation resolves partial-volume effect of MRSI as demonstrated on brain tumor scans.
    NMR in biomedicine, 2008, Volume: 21, Issue:10

    Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Humans; Image Enhancement; Image Interpretation

2008
C-11 choline PET/CT imaging for differentiating malignant from benign prostate lesions.
    Clinical nuclear medicine, 2008, Volume: 33, Issue:10

    Topics: Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Diagnosis, Differential; Humans; Male; Middl

2008
The correlation between 1H MRS choline concentrations and MR diffusion trace values in human brain tumors.
    Magma (New York, N.Y.), 2009, Volume: 22, Issue:1

    Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imagin

2009
Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo 1H MRS.
    Journal of magnetic resonance imaging : JMRI, 2008, Volume: 28, Issue:5

    Topics: Algorithms; Choline; Colonic Neoplasms; Gadolinium DTPA; HT29 Cells; Humans; Magnetic Resonance Spec

2008
High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies.
    Magma (New York, N.Y.), 2008, Volume: 21, Issue:6

    Topics: Biopsy, Needle; Choline; Creatinine; Humans; Magnetic Resonance Spectroscopy; Male; Prostatic Neopla

2008
1H-MRSI of prostate cancer: the relationship between metabolite ratio and tumor proliferation.
    European journal of radiology, 2010, Volume: 73, Issue:2

    Topics: Aged; Aged, 80 and over; Algorithms; Biomarkers, Tumor; Choline; Citric Acid; Creatine; Diagnosis, C

2010
In vivo magnetic resonance spectroscopy of gynaecological tumours at 3.0 Tesla.
    BJOG : an international journal of obstetrics and gynaecology, 2009, Volume: 116, Issue:2

    Topics: Biomarkers, Tumor; Choline; Female; Genital Neoplasms, Female; Humans; Lipids; Magnetic Resonance Sp

2009
Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI).
    Magnetic resonance in medicine, 2009, Volume: 61, Issue:3

    Topics: Adolescent; Adult; Aging; Algorithms; Brain; Brain Injuries; Choline; Female; Humans; Image Enhancem

2009
Developing a clinical decision model: MR spectroscopy to differentiate between recurrent tumor and radiation change in patients with new contrast-enhancing lesions.
    AJR. American journal of roentgenology, 2009, Volume: 192, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast

2009
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis.
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:1-2

    Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease P

2010
Role of carbon-11 choline PET/CT in the management of uterine carcinoma: initial experience.
    Annals of nuclear medicine, 2009, Volume: 23, Issue:3

    Topics: Adult; Aged; Carbon Radioisotopes; Choline; Female; Humans; Magnetic Resonance Imaging; Middle Aged;

2009
Choline for diagnosis and prognostication of acute coronary syndromes in the Emergency Department.
    Clinica chimica acta; international journal of clinical chemistry, 2009, Jun-27, Volume: 404, Issue:2

    Topics: Acute Coronary Syndrome; Aged; Choline; Early Diagnosis; Emergency Service, Hospital; Female; Follow

2009
Interaction of gadolinium-based MR contrast agents with choline: implications for MR spectroscopy (MRS) of the breast.
    Magnetic resonance in medicine, 2009, Volume: 61, Issue:6

    Topics: Animals; Artifacts; Breast; Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium; Magnetic

2009
New electrochemiluminescent biosensors combining polyluminol and an enzymatic matrix.
    Analytical and bioanalytical chemistry, 2009, Volume: 394, Issue:4

    Topics: Alcohol Oxidoreductases; Biosensing Techniques; Choline; Electrochemistry; Electrodes; Enzymes, Immo

2009
Construction of Au nanoparticles on choline chloride modified glassy carbon electrode for sensitive detection of nitrite.
    Biosensors & bioelectronics, 2009, Jul-15, Volume: 24, Issue:11

    Topics: Biosensing Techniques; Carbon; Choline; Electrochemistry; Electrodes; Equipment Design; Equipment Fa

2009
In vivo proton MR spectroscopy of the breast using the total choline peak integral as a marker of malignancy.
    AJR. American journal of roentgenology, 2009, Volume: 192, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnet

2009
Computation of brain metabolite ratios in single-voxel proton MR spectroscopy: comparison between semiautomatic and automatic software.
    La Radiologia medica, 2010, Volume: 115, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Humans; Image Processing, C

2010
Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.
    Magnetic resonance in medicine, 2009, Volume: 62, Issue:4

    Topics: Aged; Algorithms; Biomarkers, Tumor; Choline; Female; Glycine; Humans; Magnetic Resonance Spectrosco

2009
Influence of trigger PSA and PSA kinetics on 11C-Choline PET/CT detection rate in patients with biochemical relapse after radical prostatectomy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:9

    Topics: Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Humans; Male; Metabolic Clearance Rate; Midd

2009
Predictive factors of [(11)C]choline PET/CT in patients with biochemical failure after radical prostatectomy.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:2

    Topics: Aged; Aged, 80 and over; Choline; Humans; Italy; Male; Middle Aged; Positron-Emission Tomography; Pr

2010
Peripheral zone prostate cancer. Pre-treatment evaluation with MR and 3D ¹H MR spectroscopic imaging: correlation with pathologic findings.
    Abdominal imaging, 2010, Volume: 35, Issue:6

    Topics: Aged; Biopsy; Choline; Creatine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy

2010
Detection of local, regional, and distant recurrence in patients with psa relapse after external-beam radiotherapy using (11)C-choline positron emission tomography.
    International journal of radiation oncology, biology, physics, 2010, May-01, Volume: 77, Issue:1

    Topics: Aged; Carbon Radioisotopes; Choline; Follow-Up Studies; Humans; Male; Neoplasm Recurrence, Local; Po

2010
Development of a method to measure plasma and whole blood choline by liquid chromatography tandem mass spectrometry.
    Annals of clinical biochemistry, 2010, Volume: 47, Issue:Pt 1

    Topics: Blood Chemical Analysis; Blood Specimen Collection; Choline; Chromatography, Liquid; Edetic Acid; Hu

2010
Biocompatible electrochemiluminescent biosensor for choline based on enzyme/titanate nanotubes/chitosan composite modified electrode.
    Biosensors & bioelectronics, 2010, Feb-15, Volume: 25, Issue:6

    Topics: Alcohol Oxidoreductases; Biocompatible Materials; Biosensing Techniques; Chitosan; Choline; Conducto

2010
Multivariate statistical mapping of spectroscopic imaging data.
    Magnetic resonance in medicine, 2010, Volume: 63, Issue:1

    Topics: Adult; Algorithms; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Choline; Creatin

2010
Grid-free interactive and automated data processing for MR chemical shift imaging data.
    Magma (New York, N.Y.), 2010, Volume: 23, Issue:1

    Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Elect

2010
Quantitative multivoxel proton chemical shift imaging of the breast.
    Magnetic resonance imaging, 2010, Volume: 28, Issue:3

    Topics: Algorithms; Biomarkers, Tumor; Breast; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; Fema

2010
Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media;

2010
18F choline PET/CT in the preoperative staging of prostate cancer in patients with intermediate or high risk of extracapsular disease: a prospective study of 130 patients.
    Radiology, 2010, Volume: 254, Issue:3

    Topics: Aged; Choline; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Stagi

2010
Validation of automatic target volume definition as demonstrated for 11C-choline PET/CT of human prostate cancer using multi-modality fusion techniques.
    Academic radiology, 2010, Volume: 17, Issue:5

    Topics: Algorithms; Artificial Intelligence; Carbon Radioisotopes; Choline; Humans; Image Enhancement; Image

2010
[Positron emission tomography with special tracers in pulmonary abnormalities].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2010, Jan-15, Volume: 48, Issue:2

    Topics: Choline; Diagnosis, Differential; Dideoxynucleosides; Female; Humans; Iodoacetates; Lung Diseases; M

2010
Quantitative proton MRI and MRS of the rat brain with a 3T clinical MR scanner.
    Journal of neuroradiology = Journal de neuroradiologie, 2011, Volume: 38, Issue:2

    Topics: Algorithms; Animals; Aspartic Acid; Brain; Choline; Creatine; Female; Magnetic Resonance Imaging; Ma

2011
Gliomatosis cerebri, imaging findings of 12 cases.
    Journal of neuroradiology = Journal de neuroradiologie, 2010, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Child; Choline; Creatine

2010
Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM.
    Neuro-oncology, 2010, Volume: 12, Issue:11

    Topics: Biomarkers, Tumor; Brain Neoplasms; Choline; Glioblastoma; Humans; Image Interpretation, Computer-As

2010
Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas.
    European journal of radiology, 2011, Volume: 80, Issue:2

    Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Im

2011
Pilot comparison of F-fluorocholine and F-fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer.
    Journal of medical imaging and radiation oncology, 2010, Volume: 54, Issue:4

    Topics: Aged; Choline; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Stagin

2010
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy.
    Magnetic resonance imaging, 2011, Volume: 29, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Creatine; Female; Glioma; H

2011
Combined DCE-MRI and single-voxel 2D MRS for differentiation between benign and malignant breast lesions.
    NMR in biomedicine, 2010, Volume: 23, Issue:8

    Topics: Breast Neoplasms; Choline; Contrast Media; Female; Humans; Magnetic Resonance Imaging; Magnetic Reso

2010
Detection of fully refocused polyamine spins in prostate cancer at 7 T.
    NMR in biomedicine, 2011, Volume: 24, Issue:3

    Topics: Biomarkers, Tumor; Choline; Citric Acid; Creatine; Humans; Magnetic Resonance Spectroscopy; Male; Po

2011
Choline esterase and its specificity.
    Nature, 1946, May-04, Volume: 157

    Topics: Choline; Cholinesterases; Esterases; Sensitivity and Specificity

1946
Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Dec-15, Volume: 878, Issue:32

    Topics: Acetylcholine; Adult; Betaine; Choline; Chromatography, High Pressure Liquid; Drug Stability; Female

2010
Diffusion-weighted imaging and magnetic resonance spectroscopy of sporadic Creutzfeldt-Jakob disease: correlation with clinical course.
    Neuroradiology, 2011, Volume: 53, Issue:12

    Topics: Aged; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Creutzfeldt-Jakob Syndrome; Diffusion Mag

2011
Simultaneous detection of guanine, adenine, thymine and cytosine at choline monolayer supported multiwalled carbon nanotubes film.
    Biosensors & bioelectronics, 2011, Mar-15, Volume: 26, Issue:7

    Topics: Adenine; Animals; Choline; Cytosine; DNA; Electrochemical Techniques; Fishes; Guanine; Nanotubes, Ca

2011
Preliminary study of 11C-choline PET/CT for T staging of locally advanced nasopharyngeal carcinoma: comparison with 18F-FDG PET/CT.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:3

    Topics: Adult; Aged; Carbon Radioisotopes; Choline; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Age

2011
The role of MRS in the differentiation of benign and malignant soft tissue and bone tumors.
    European journal of radiology, 2011, Volume: 79, Issue:2

    Topics: Adolescent; Adult; Aged; Bone Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Female; G

2011
Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's disease.
    European radiology, 2011, Volume: 21, Issue:9

    Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Imaging, Three-Dimensi

2011
The sensitivity of [11C]choline PET/CT to localize prostate cancer depends on the tumor configuration.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jun-01, Volume: 17, Issue:11

    Topics: Aged; Choline; Humans; Male; Middle Aged; Neoplasm Staging; Positron-Emission Tomography; Prostatic

2011
Histopathological correlation of (11)C-choline PET scans for target volume definition in radical prostate radiotherapy.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2011, Volume: 99, Issue:2

    Topics: Aged; Analysis of Variance; Choline; Combined Modality Therapy; Fluorodeoxyglucose F18; Humans; Male

2011
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
    Magnetic resonance in medicine, 2012, Volume: 67, Issue:1

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies;

2012
Fluorocholine (18F) and sodium fluoride (18F) PET/CT in the detection of prostate cancer: prospective comparison of diagnostic performance determined by masked reading.
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2011, Volume: 55, Issue:4

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Choline; Fluorine Radioisotopes; Humans; Male; Middle Aged;

2011
Improved quality control of [18F]fluoromethylcholine.
    Nuclear medicine and biology, 2011, Volume: 38, Issue:8

    Topics: Choline; Chromatography, Gas; Chromatography, High Pressure Liquid; Deanol; Humans; Hydrocarbons, Br

2011
Role of ¹¹C-choline positron emission tomography/computed tomography in evaluating patients affected by prostate cancer with suspected relapse due to prostate-specific antigen elevation.
    Japanese journal of radiology, 2011, Volume: 29, Issue:6

    Topics: Aged; Choline; Contrast Media; Endpoint Determination; Humans; Male; Multimodal Imaging; Neoplasm Re

2011
Oxidase-functionalized Fe(3)O(4) nanoparticles for fluorescence sensing of specific substrate.
    Analytica chimica acta, 2011, Oct-03, Volume: 703, Issue:1

    Topics: Adult; Alcohol Oxidoreductases; Allyl Compounds; Biosensing Techniques; Blood Glucose; Choline; Fluo

2011
Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions.
    NMR in biomedicine, 2012, Volume: 25, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Body Mass Index; Brain; Choline; Female; Humans; Magnetic Resonan

2012
Multimodal assessment of early tumor response to chemotherapy: comparison between diffusion-weighted MRI, 1H-MR spectroscopy of choline and USPIO particles targeted at cell death.
    NMR in biomedicine, 2012, Volume: 25, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Choline; Dextrans; D

2012
Multivoxel proton MR spectroscopy used to distinguish anterior cingulate metabolic abnormalities in patients with schizophrenia.
    Radiology, 2011, Volume: 261, Issue:2

    Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Gyrus Cinguli; Humans; Image

2011
[11C]Choline PET/CT detection of bone metastases in patients with PSA progression after primary treatment for prostate cancer: comparison with bone scintigraphy.
    European journal of nuclear medicine and molecular imaging, 2012, Volume: 39, Issue:1

    Topics: Aged; Aged, 80 and over; Bone and Bones; Bone Neoplasms; Carbon Radioisotopes; Choline; Humans; Male

2012
A sensitive choline biosensor using Fe3O4 magnetic nanoparticles as peroxidase mimics.
    The Analyst, 2011, Dec-07, Volume: 136, Issue:23

    Topics: Alcohol Oxidoreductases; Ascorbic Acid; Biosensing Techniques; Choline; Ferric Compounds; Gold; Magn

2011
Three-dimensional proton MR spectroscopic imaging at 3 T for the differentiation of benign and malignant breast lesions.
    Radiology, 2011, Volume: 261, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Biopsy, Needle; Breast Neoplasms; Choline; Diagnosis, Differential;

2011
Feasibility of TCP-based dose painting by numbers applied to a prostate case with (18)F-choline PET imaging.
    Zeitschrift fur medizinische Physik, 2012, Volume: 22, Issue:1

    Topics: Algorithms; Artifacts; Choline; Feasibility Studies; Humans; Image Processing, Computer-Assisted; Ma

2012
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu

2012
Indirect electrocatalytic determination of choline by monitoring hydrogen peroxide at the choline oxidase-prussian blue modified iron phosphate nanostructures.
    Biosensors & bioelectronics, 2012, Jan-15, Volume: 31, Issue:1

    Topics: Alcohol Oxidoreductases; Biosensing Techniques; Catalysis; Choline; Conductometry; Enzymes, Immobili

2012
In vivo characterisation of soft tissue tumours by 1.5-T proton MR spectroscopy.
    European radiology, 2012, Volume: 22, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Choline; Diagnosis, Computer-Assisted; Female; Hu

2012
Multienzyme microbiosensor based on electropolymerized o-phenylenediamine for simultaneous in vitro determination of acetylcholine and choline.
    Biosensors & bioelectronics, 2012, Jan-15, Volume: 31, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Alcohol Oxidoreductases; Biosensing Techniques; Choline; Conduc

2012
F-18 choline PET does not detect increased metabolism in F-18 fluoroethyltyrosine-negative low-grade gliomas.
    Clinical nuclear medicine, 2012, Volume: 37, Issue:1

    Topics: Adult; Brain Neoplasms; Choline; False Negative Reactions; Female; Glioma; Humans; Male; Middle Aged

2012
Study of single voxel 1H MR spectroscopy of bone tumors: differentiation of benign from malignant tumors.
    European journal of radiology, 2013, Volume: 82, Issue:12

    Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Bone Neoplasms; Child; Choline; Diagnosis, Differential;

2013
An evaluation of motion compensation strategies and repeatability for abdominal (1)H MR spectroscopy measurements in volunteer studies and clinical trials.
    NMR in biomedicine, 2012, Volume: 25, Issue:6

    Topics: Abdominal Neoplasms; Artifacts; Biomarkers, Tumor; Choline; Clinical Trials as Topic; Diagnosis, Com

2012
Diagnostic efficacy of [11C]choline positron emission tomography/computed tomography compared with conventional computed tomography in lymph node staging of patients with bladder cancer prior to radical cystectomy.
    European urology, 2012, Volume: 61, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma; Choline; Cystectomy; Female; Humans

2012
Association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status with total choline concentration and tumor volume in breast cancer patients: an MRI and in vivo proton MRS study.
    Magnetic resonance in medicine, 2012, Volume: 68, Issue:4

    Topics: Aged; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Imaging, Three-Dimensional; Magn

2012
Is there an additional value of ¹¹C-choline PET-CT to T2-weighted MRI images in the localization of intraprostatic tumor nodules?
    International journal of radiation oncology, biology, physics, 2012, Aug-01, Volume: 83, Issue:5

    Topics: Aged; Biopsy; Carbon Radioisotopes; Choline; Humans; Magnetic Resonance Imaging; Male; Middle Aged;

2012
[11C]choline PET for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT.
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2012, Volume: 56, Issue:2

    Topics: Aged; Carbon Radioisotopes; Choline; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local;

2012
Correlation of diffusion and metabolic alterations in different clinical forms of multiple sclerosis.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Adult; Aspartic Acid; Choline; Diffusion; Diffusion Tensor Imaging; Humans; Image Processing, Comput

2012
Enhanced choline metabolism in a rodent rhabdomyosarcoma model: correlation between RT-PCR and translational 3 T H-MRS.
    Magnetic resonance imaging, 2012, Volume: 30, Issue:7

    Topics: Animals; Choline; Magnetic Resonance Spectroscopy; Protons; Rats; Real-Time Polymerase Chain Reactio

2012
Reproducibility of total choline/water ratios in mouse U87MG xenograft tumors by 1H-MRS.
    Journal of magnetic resonance imaging : JMRI, 2012, Volume: 36, Issue:2

    Topics: Animals; Biomarkers, Tumor; Body Water; Cell Line, Tumor; Choline; Glioblastoma; Humans; Magnetic Re

2012
[18F]fluoromethylcholine (FCH) positron emission tomography/computed tomography (PET/CT) for lymph node staging of prostate cancer: a prospective study of 210 patients.
    BJU international, 2012, Volume: 110, Issue:11

    Topics: Aged; Bone Neoplasms; Choline; Fluorine Radioisotopes; Humans; Lymph Node Excision; Lymph Nodes; Lym

2012
Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the quantification of lipid-related extracellular metabolites in Saccharomyces cerevisiae.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, May-15, Volume: 897

    Topics: Choline; Chromatography, Liquid; Fungal Proteins; Gene Deletion; Glycerophospholipids; Hydrophobic a

2012
Role of 11C-choline PET/CT in the re-staging of prostate cancer patients with biochemical relapse and negative results at bone scintigraphy.
    European journal of radiology, 2012, Volume: 81, Issue:8

    Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Bone and Bones; Carbon Radioisotopes; Choline; Humans; M

2012
Magnetic resonance spectroscopy of the breast at 3T: pre- and post-contrast evaluation for breast lesion characterization.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Contrast Media; Early Detection of Cancer; Female; G

2012
[18F]choline positron emission tomography in prostate cancer patients with biochemical recurrence after radical prostatectomy: influence of antiandrogen therapy - a preliminary study.
    Nuclear medicine communications, 2012, Volume: 33, Issue:8

    Topics: Aged; Aged, 80 and over; Androgen Antagonists; Choline; Fluorine Radioisotopes; Follow-Up Studies; H

2012
Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms.
    Journal of vascular surgery, 2012, Volume: 56, Issue:3

    Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Autoradiography; Chemotaxis, Leukocyte; Choli

2012
Non-water-suppressed proton MR spectroscopy improves spectral quality in the human spinal cord.
    Magnetic resonance in medicine, 2013, Volume: 69, Issue:5

    Topics: Adult; Algorithms; Aspartic Acid; Body Water; Choline; Creatine; Female; Humans; Inositol; Magnetic

2013
The effect of paramagnetic contrast in choline peak in patients with glioblastoma multiforme might not be significant.
    AJNR. American journal of neuroradiology, 2013, Volume: 34, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Choline; Contrast Media; Electron Spin Reson

2013
(1)H MR spectroscopy with external reference solution at 1.5 T for differentiating malignant and benign breast lesions: comparison using qualitative and quantitative approaches.
    European radiology, 2013, Volume: 23, Issue:1

    Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Female; Gadolinium

2013
Quantitative mapping of total choline in healthy human breast using proton echo planar spectroscopic imaging (PEPSI) at 3 Tesla.
    Journal of magnetic resonance imaging : JMRI, 2012, Volume: 36, Issue:5

    Topics: Adult; Algorithms; Breast; Choline; Echo-Planar Imaging; Female; Humans; Magnetic Resonance Spectros

2012
Impact of total PSA, PSA doubling time and PSA velocity on detection rates of 11C-Choline positron emission tomography in recurrent prostate cancer.
    World journal of urology, 2013, Volume: 31, Issue:2

    Topics: Aged; Biomarkers, Tumor; Carbon Radioisotopes; Choline; Disease Progression; Humans; Kallikreins; Ma

2013
Liver metabolite concentrations measured with 1H MR spectroscopy.
    Radiology, 2012, Volume: 265, Issue:2

    Topics: Choline; Feasibility Studies; Female; Glycogen; Humans; Liver; Magnetic Resonance Spectroscopy; Male

2012
Non-spin-echo 3D transverse hadamard encoded proton spectroscopic imaging in the human brain.
    Magnetic resonance in medicine, 2013, Volume: 70, Issue:1

    Topics: Adult; Algorithms; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Healthy Volunte

2013
1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer.
    Magma (New York, N.Y.), 2013, Volume: 26, Issue:3

    Topics: Biomarkers, Tumor; Biopsy, Fine-Needle; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; Fem

2013
L-COSY of breast cancer at 3T.
    European journal of radiology, 2012, Volume: 81 Suppl 1

    Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted;

2012
Malignant transformation: the role of MRS.
    European journal of radiology, 2012, Volume: 81 Suppl 1

    Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Choline; Diagnosis, Computer-Assisted; Glucose;

2012
Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T.
    Magnetic resonance in medicine, 2013, Volume: 69, Issue:2

    Topics: Adult; Aspartic Acid; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Evoked Potentials, Vi

2013
(1) H magnetic resonance spectroscopy of neurodegeneration in a mouse model of niemann-pick type C1 disease.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 37, Issue:5

    Topics: Animals; Aspartic Acid; Biomarkers; Brain; Choline; Magnetic Resonance Spectroscopy; Mice; Mice, Inb

2013
Prostate 3T-MR spectroscopic imaging without an endorectal surface coil using the MLEV-PRESS sequence.
    Japanese journal of radiology, 2013, Volume: 31, Issue:3

    Topics: Biomarkers; Chelating Agents; Choline; Citric Acid; Humans; Image Processing, Computer-Assisted; Lip

2013
Validation of an LC-MS/MS method for the quantification of choline-related compounds and phospholipids in foods and tissues.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Dec-12, Volume: 911

    Topics: Animals; Calibration; Choline; Chromatography, Liquid; Egg Yolk; Eggs; Food Analysis; Gastric Mucosa

2012
Comparative assessment of segmentation algorithms for tumor delineation on a test-retest [(11)C]choline dataset.
    Medical physics, 2012, Volume: 39, Issue:12

    Topics: Algorithms; Artificial Intelligence; Breast Neoplasms; Carbon Radioisotopes; Choline; Female; Humans

2012
Reproducibility of brain spectroscopy at 7T using conventional localization and spectral editing techniques.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 38, Issue:2

    Topics: Aspartic Acid; Brain; Choline; Creatinine; Female; Healthy Volunteers; Humans; Image Interpretation,

2013
Optimisation of choline testing using Florence Iodine reagent, including comparative sensitivity and specificity with PSA and AP tests.
    Science & justice : journal of the Forensic Science Society, 2013, Volume: 53, Issue:1

    Topics: Acid Phosphatase; Choline; Female; Forensic Medicine; Humans; Indicators and Reagents; Iodine; Male;

2013
[[¹¹C]choline as a pharmacodynamic marker for docetaxel therapy. Response assessment in a LNCaP prostate cancer xenograft mouse model].
    Nuklearmedizin. Nuclear medicine, 2013, Volume: 52, Issue:4

    Topics: Animals; Antineoplastic Agents; Carbon Radioisotopes; Cell Line, Tumor; Choline; Docetaxel; Male; Mi

2013
An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region.
    Head & neck, 2002, Volume: 24, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Algorithms; Carcinoma, Squamous Cell; Choline; Creatine; Female; Hea

2002
Breast cancer: in vivo proton MR spectroscopy in the characterization of histopathologic subtypes and preliminary observations in axillary node metastases.
    Radiology, 2002, Volume: 225, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Axilla; Biopsy, Needle; Breast Neoplasms; Carcinoma, Ductal, Breast;

2002
Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2002, Volume: 47, Issue:7

    Topics: Adult; Aspartic Acid; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Hippocampus

2002
Nonaqueous capillary electrophoresis with indirect electrochemical detection.
    Electrophoresis, 2002, Volume: 23, Issue:21

    Topics: Acetonitriles; Acetylcholine; Choline; Electrochemistry; Electrophoresis, Capillary; Organometallic

2002
Amperometric determination of choline released from rat submandibular gland acinar cells using a choline oxidase biosensor.
    Biosensors & bioelectronics, 2003, Volume: 18, Issue:2-3

    Topics: Adenosine Triphosphate; Alcohol Oxidoreductases; Animals; Biosensing Techniques; Choline; Coated Mat

2003
[The (11C) acetate positron emission tomography in prostatic carcinoma. New prospects in metabolic imaging].
    Der Urologe. Ausg. A, 2002, Volume: 41, Issue:6

    Topics: Acetates; Adenocarcinoma; Amino Acids; Biopsy; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18

2002
MR spectroscopic pulvinar sign in a case of variant Creutzfeldt-Jakob disease.
    Journal of neuroradiology = Journal de neuroradiologie, 2002, Volume: 29, Issue:4

    Topics: Adult; Aspartic Acid; Biopsy; Case-Control Studies; Choline; Creatine; Creutzfeldt-Jakob Syndrome; F

2002
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat

2003
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
    Annales de medecine interne, 2002, Volume: 153, Issue:8

    Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia

2002
11C-choline PET for the detection of bone and soft tissue tumours in comparison with FDG PET.
    Nuclear medicine communications, 2003, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biological Transport; Bone Diseases; Bone Neoplasms; Car

2003
Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003, Volume: 44, Issue:3

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Choline; Humans; Image Processing, Computer-Assisted; Ly

2003
Value of [11C]choline-positron emission tomography for re-staging prostate cancer: a comparison with [18F]fluorodeoxyglucose-positron emission tomography.
    The Journal of urology, 2003, Volume: 169, Issue:4

    Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; H

2003
Improved method for the routine determination of acetylcholine and choline in brain microdialysate using a horseradish peroxidase column as the immobilized enzyme reactor.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, May-05, Volume: 788, Issue:1

    Topics: Acetylcholine; Animals; Brain; Choline; Enzymes, Immobilized; Horseradish Peroxidase; Microdialysis;

2003
Leakage of metabolites from tissue biopsies can result in large errors in quantitation by MRS.
    NMR in biomedicine, 2003, Volume: 16, Issue:2

    Topics: Animals; Artifacts; Biopsy; Cerebral Cortex; Choline; Citrates; Cryopreservation; Humans; Magnetic R

2003
Pathologic characterization of human prostate tissue with proton MR spectroscopy.
    Radiology, 2003, Volume: 228, Issue:1

    Topics: Adenocarcinoma; Biomarkers, Tumor; Choline; Citrates; Creatinine; Diagnosis, Differential; Humans; L

2003
In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of former prisoners of war with and without posttraumatic stress disorder.
    The Journal of neuropsychiatry and clinical neurosciences, 2003,Summer, Volume: 15, Issue:3

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy;

2003
Comparison of polarization transfer sequences for enhancement of signals in clinical 31P MRS studies.
    Magnetic resonance in medicine, 2003, Volume: 50, Issue:3

    Topics: Chi-Square Distribution; Choline; Magnetic Resonance Spectroscopy; Models, Theoretical; Neoplasms; P

2003
Uptake rates of 18F-fluorodeoxyglucose and 11C-choline in lung cancer and pulmonary tuberculosis: a positron emission tomography study.
    Chest, 2003, Volume: 124, Issue:3

    Topics: Aged; Aged, 80 and over; Blood Glucose; Carbon Radioisotopes; Choline; Diagnosis, Differential; Fema

2003
The N-alkyl group specificity of choline acetylase from rat brain.
    Journal of neurochemistry, 1963, Volume: 10

    Topics: Acetylesterase; Animals; Brain; Choline; Choline O-Acetyltransferase; Rats; Sensitivity and Specific

1963
A COMPARISON OF THE N-ALKYL GROUP SPECIFICITY OF CHOLINE ACETYLTRANSFERASE FROM DIFFERENT SPECIES.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Acetylcholine; Acyltransferases; Ammonium Compounds; Animals; Brain; Choline; Choline O-Acetyltransf

1964
Electrochemiluminescent biosensors array for the concomitant detection of choline, glucose, glutamate, lactate, lysine and urate.
    Biosensors & bioelectronics, 2003, Dec-30, Volume: 19, Issue:5

    Topics: Biosensing Techniques; Choline; Complex Mixtures; Electrochemistry; Enzymes, Immobilized; Equipment

2003
18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET.
    European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:3

    Topics: Animals; Autoradiography; Choline; Fluorodeoxyglucose F18; Metabolic Clearance Rate; Muscle, Skeleta

2004
Saturation-corrected T 1 and T 2 relaxation times of choline, creatine and N-acetyl aspartate in human cerebral white matter at 1.5 T.
    NMR in biomedicine, 2003, Volume: 16, Issue:5

    Topics: Adult; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Image Interpretation, Computer-A

2003
In vivo 1H-MRS evaluation of malignant and benign breast diseases.
    Breast (Edinburgh, Scotland), 2003, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Diagnosis, Differenti

2003
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
    Analytical chemistry, 2003, Oct-15, Volume: 75, Issue:20

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc

2003
Low-grade gliomas and focal cortical developmental malformations: differentiation with proton MR spectroscopy.
    Radiology, 2004, Volume: 230, Issue:3

    Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Cerebral Cortex; Child; Choline; Creatine; Diagnosis,

2004
[Magnetic resonance imaging spectroscopy. Part 1: Basics].
    Der Radiologe, 2003, Volume: 43, Issue:12

    Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Energy Metabolism; Humans; Image Enh

2003
(1)H magnetic resonance spectroscopy of preinvasive and invasive cervical cancer: in vivo-ex vivo profiles and effect of tumor load.
    Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Analysis of Variance; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chol

2004
Is 11C-choline the most appropriate tracer for prostate cancer? Against.
    European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:5

    Topics: Carbon Radioisotopes; Choline; Clinical Trials as Topic; Evidence-Based Medicine; Humans; Male; Posi

2004
Is 11C-choline the most appropriate tracer for prostate cancer? For.
    European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:5

    Topics: Carbon Radioisotopes; Choline; Clinical Trials as Topic; Evidence-Based Medicine; Humans; Male; Posi

2004
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy?
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2004, Volume: 14, Issue:2

    Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance

2004
Neuropsychological correlates of basal ganglia and medial temporal lobe NAA/Cho reductions in traumatic brain injury.
    Archives of neurology, 2004, Volume: 61, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Basal Ganglia; Brain Injury, Chronic; Choline; Female; Glasgow Com

2004
Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 97, Issue:3

    Topics: Administration, Inhalation; Aerosols; Animals; Aspergillosis; Bronchial Provocation Tests; Bronchoal

2004
Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TlCl single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging.
    Journal of neurosurgery, 2004, Volume: 100, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Neoplasms; Choline; Contrast Media; Fema

2004
A performance comparison of choline biosensors: anodic or cathodic detections of H2O2 generated by enzyme immobilized on a conducting polymer.
    Biosensors & bioelectronics, 2004, Jul-15, Volume: 19, Issue:12

    Topics: Alcohol Oxidoreductases; Biosensing Techniques; Choline; Coenzymes; Electric Conductivity; Electroch

2004
[Usefulness of Cho/Cr ratio in proton MR spectroscopy for differentiating residual/recurrent glioma from non-neoplastic lesions].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 2004, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Female; Glioma

2004
Characterization of bone and soft-tissue tumors with in vivo 1H MR spectroscopy: initial results.
    Radiology, 2004, Volume: 232, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Bone Neoplasms; Choline; Diagnosis, Diff

2004
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004, Volume: 45, Issue:8

    Topics: Adenocarcinoma; Aged; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Japan;

2004
Simultaneous determination of allantoin, choline and L-arginine in Rhizoma Dioscoreae by capillary electrophoresis.
    Journal of chromatography. A, 2004, Jul-23, Volume: 1043, Issue:2

    Topics: Allantoin; Araceae; Arginine; Choline; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Medic

2004
Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T.
    European radiology, 2005, Volume: 15, Issue:5

    Topics: Adult; Aged; Breast Neoplasms; Case-Control Studies; Choline; Female; Humans; Magnetic Resonance Ima

2005
Positron emission tomographic imaging with 11C-choline in differential diagnosis of head and neck tumors: comparison with 18F-FDG PET.
    Annals of nuclear medicine, 2004, Volume: 18, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Diagnosis, Differential; Female; Fluo

2004
Synthesis and preclinical evaluation of the choline transport tracer deshydroxy-[18F]fluorocholine ([18F]dOC).
    Nuclear medicine and biology, 2004, Volume: 31, Issue:7

    Topics: Animals; Biological Transport; Biomarkers, Tumor; Cell Line, Tumor; Choline; Dose-Response Relations

2004
Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate.
    Nuclear medicine and biology, 2004, Volume: 31, Issue:7

    Topics: Acetates; Animals; Biomarkers, Tumor; Carbon Radioisotopes; Cell Line, Tumor; Cell Proliferation; Ch

2004
123I-IMT SPECT and 1H MR-spectroscopy at 3.0 T in the differential diagnosis of recurrent or residual gliomas: a comparative study.
    Journal of neuro-oncology, 2004, Volume: 70, Issue:1

    Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Female; Glioblastoma; Huma

2004
Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Femal

2004
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy.
    Journal of neurosurgery, 2005, Volume: 102, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Child, Preschool; Cho

2005
Application of bubble separation for quantitative analysis of choline in Dioscorea (yam) tubers.
    Journal of agricultural and food chemistry, 2005, Apr-06, Volume: 53, Issue:7

    Topics: Adhesives; Avena; Choline; Dioscorea; Flour; Food Analysis; Oryza; Plant Tubers; Sensitivity and Spe

2005
Classification of the mode of inhibition of high-affinity choline uptake using capillary electrophoresis with electrochemical detection at an enzyme-modified microelectrode.
    Analytical biochemistry, 2005, Apr-15, Volume: 339, Issue:2

    Topics: Acetylcholinesterase; Alcohol Oxidoreductases; Animals; Choline; Cholinergic Agents; Electrochemistr

2005
Quantification of choline compounds in human hepatic tumors by proton MR spectroscopy at 3 T.
    Magnetic resonance in medicine, 2005, Volume: 53, Issue:4

    Topics: Brain; Carcinoma, Hepatocellular; Choline; Humans; Liver; Liver Neoplasms; Magnetic Resonance Imagin

2005
Electrochemistry of sinapine and its detection in medicinal plants.
    Analytical and bioanalytical chemistry, 2005, Volume: 382, Issue:4

    Topics: Choline; Electrochemistry; Hydrogen-Ion Concentration; Lepidium; Molecular Structure; Mustard Plant;

2005
An improved 1H magnetic resonance spectroscopic imaging technique for the human breast: preliminary results.
    Magnetic resonance imaging, 2005, Volume: 23, Issue:4

    Topics: Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium DTPA; Humans; Magnetic Resonance Spect

2005
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:8

    Topics: Carcinoma, Squamous Cell; Choline; Creatine; Female; Head and Neck Neoplasms; Humans; Lactic Acid; L

2005
Electrosynthesized poly(pyrrole)/poly(2-naphthol) bilayer membrane as an effective anti-interference layer for simultaneous determination of acethylcholine and choline by a dual electrode amperometric biosensor.
    Biosensors & bioelectronics, 2006, Mar-15, Volume: 21, Issue:9

    Topics: Acetylcholine; Acetylcholinesterase; Alcohol Oxidoreductases; Biosensing Techniques; Choline; Electr

2006
Detection and localization of prostate cancer: correlation of (11)C-choline PET/CT with histopathologic step-section analysis.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:10

    Topics: Aged; Choline; Female; Humans; Image Enhancement; Male; Middle Aged; Neoplasm Staging; Positron-Emis

2005
18F-choline images murine atherosclerotic plaques ex vivo.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:3

    Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Autoradiography; Choline; Choline Kinase; Fluori

2006
Rapid high-throughput detection of peroxide with an acridinium-9-carboxamide: a homogeneous chemiluminescent assay for plasma choline.
    Bioorganic & medicinal chemistry letters, 2006, May-01, Volume: 16, Issue:9

    Topics: Acridines; Betaine; Choline; Humans; Hydrogen Peroxide; Luminescent Measurements; Molecular Structur

2006
Positive correlations between cerebral choline and renal dysfunction in chronic renal failure.
    Neuroradiology, 2006, Volume: 48, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Glutamic

2006
Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study.
    Radiology, 2006, Volume: 239, Issue:3

    Topics: Adult; Aged; Biomarkers, Tumor; Biopsy; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonanc

2006
[Value of carbon-11 choline positron emission tomography in patients with pulmonary abnormalities].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2006, Mar-15, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Female; Humans; Lung; Lung Diseases;

2006
Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients.
    Radiology, 2006, Volume: 239, Issue:3

    Topics: Age Factors; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Brain Edema; Cause of Death; Cerebra

2006
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:11

    Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv

2006
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:11

    Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv

2006
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:11

    Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv

2006
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:11

    Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv

2006
11C-choline positron emission tomography/computerized tomography for tumor localization of primary prostate cancer in comparison with 12-core biopsy.
    The Journal of urology, 2006, Volume: 176, Issue:3

    Topics: Aged; Biopsy, Needle; Carbon Radioisotopes; Choline; Humans; Male; Middle Aged; Positron-Emission To

2006
Clinical PET in oncology: not only FDG.
    Nuclear medicine communications, 2006, Volume: 27, Issue:9

    Topics: Acetates; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Gallium Radioisotopes; Humans; Medi

2006
Value of 11C-choline PET and PET/CT in patients with suspected prostate cancer.
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:1

    Topics: Aged; Aged, 80 and over; Algorithms; Carbon Radioisotopes; Choline; Humans; Image Enhancement; Image

2007
Evaluation of spectral selected press sequence in breast lesion characterization.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2006, Volume: 21, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Female; Fibroa

2006
Choline biosensor constructed with chitinous membrane from soldier crab and its application in measuring cholinesterase inhibitory activities.
    Journal of pharmaceutical and biomedical analysis, 2007, Nov-30, Volume: 45, Issue:4

    Topics: Alcaligenes; Alcohol Oxidoreductases; Animals; Biosensing Techniques; Brachyura; Chitin; Choline; Ch

2007
(1)H MR spectroscopic imaging in patients with MRI-negative extratemporal epilepsy: correlation with ictal onset zone and histopathology.
    European radiology, 2007, Volume: 17, Issue:8

    Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Child; Choline; Creatine; Electroencephalography; E

2007
Improved automated synthesis of [18F]fluoroethylcholine as a radiotracer for cancer imaging.
    Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9

    Topics: Choline; Chromatography, High Pressure Liquid; Fluorine Radioisotopes; Molecular Structure; Neoplasm

2007
Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy.
    Diagnostic and interventional radiology (Ankara, Turkey), 2007, Volume: 13, Issue:1

    Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imaging;

2007
11C-choline positron-emission tomography/computed tomography and transrectal ultrasonography for staging localized prostate cancer.
    BJU international, 2007, Volume: 99, Issue:6

    Topics: Aged; Carbon Radioisotopes; Choline; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Stag

2007
Proton magnetic resonance spectroscopy for radiation encephalopathy induced by radiotherapy for nasopharyngeal carcinoma.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain Diseases; Choline; Creatine; Female; Humans; Magnetic Resonance Sp

2007
Magnetic resonance spectroscopy as a diagnostic modality for carcinoma thyroid.
    European journal of radiology, 2007, Volume: 64, Issue:3

    Topics: Adenocarcinoma, Follicular; Adenocarcinoma, Mucinous; Adenoma; Adolescent; Adult; Biopsy, Fine-Needl

2007
Characterization of procaine metabolism as probe for the butyrylcholinesterase enzyme investigation by simultaneous determination of procaine and its metabolite using capillary electrophoresis with electrochemiluminescence detection.
    Journal of chromatography. A, 2007, Jun-22, Volume: 1154, Issue:1-2

    Topics: Acetylcholine; Butyrylcholinesterase; Choline; Cholinesterase Inhibitors; Electrochemistry; Electrop

2007
Characterization of musculoskeletal lesions on 3-T proton MR spectroscopy.
    AJR. American journal of roentgenology, 2007, Volume: 188, Issue:6

    Topics: Adolescent; Adult; Biomarkers; Bone Neoplasms; Choline; Female; Humans; Magnetic Resonance Spectrosc

2007
Retro-orbital injection is an effective route for radiopharmaceutical administration in mice during small-animal PET studies.
    Nuclear medicine communications, 2007, Volume: 28, Issue:7

    Topics: Animals; Carbon Radioisotopes; Choline; Female; Fluorodeoxyglucose F18; Image Enhancement; Injection

2007
Whole blood choline and plasma choline in acute coronary syndromes: prognostic and pathophysiological implications.
    Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 383, Issue:1-2

    Topics: Aged; Choline; Chromatography, High Pressure Liquid; Coronary Artery Disease; Coronary Disease; Fema

2007
[Pro and contra: 11C choline PET in diagnosis of prostate cancer].
    Aktuelle Urologie, 2007, Volume: 38, Issue:3

    Topics: Carbon Radioisotopes; Choline; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imagi

2007
Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging.
    Neuroradiology, 2007, Volume: 49, Issue:10

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Blood Flow Velocity; Brain; Brain Neoplasms; Choline

2007
11C/ 18F-choline PET or 11C/18F-acetate PET in prostate cancer: may a choice be recommended?
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:10

    Topics: Acetates; Carbon Radioisotopes; Choline; Fluorine Radioisotopes; Humans; Image Enhancement; Male; Po

2007
Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT.
    Radiology, 2007, Volume: 244, Issue:3

    Topics: Adult; Aged; Biopsy; Carbon Radioisotopes; Choline; Humans; Image Processing, Computer-Assisted; Ima

2007
[Comparison of the accuracy of manual and automatic evaluation of MR spectra in prostate carcinoma].
    Der Urologe. Ausg. A, 2007, Volume: 46, Issue:9

    Topics: Choline; Citrates; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic

2007
Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer.
    BJU international, 2007, Volume: 100, Issue:4

    Topics: Aged; Choline; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm St

2007
Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer.
    BJU international, 2007, Volume: 100, Issue:4

    Topics: Aged; Choline; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm St

2007
Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer.
    BJU international, 2007, Volume: 100, Issue:4

    Topics: Aged; Choline; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm St

2007
Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer.
    BJU international, 2007, Volume: 100, Issue:4

    Topics: Aged; Choline; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm St

2007
The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis.
    Pediatric radiology, 2007, Volume: 37, Issue:11

    Topics: Aspartic Acid; Biomarkers, Tumor; Cerebellar Neoplasms; Cerebellum; Child; Choline; Creatine; Humans

2007
Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Animals; Biological Transport; Brain; Catechols; Choline; Cholinergic Agents; Dose-Response Relation

2007
Evaluation of [(18)F]-choline PET/CT for staging and restaging of prostate cancer.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:2

    Topics: Aged; Choline; Fluorine Radioisotopes; Humans; Male; Middle Aged; Neoplasm Staging; Positron-Emissio

2008
Short-TE localised 1H MRS of the human brain at 3 T: quantification of the metabolite signals using two approaches to account for macromolecular signal contributions.
    NMR in biomedicine, 2008, Volume: 21, Issue:5

    Topics: Adult; Aspartic Acid; Body Water; Brain; Choline; Creatine; Echo-Planar Imaging; Female; Glucose; Gl

2008
"Absolute" quantification in magnetic resonance spectroscopy: validation of a clinical protocol in multiple sclerosis.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2007, Volume: 2007

    Topics: Adult; Algorithms; Aspartic Acid; Biomarkers; Brain; Choline; Diagnosis, Computer-Assisted; Female;

2007
Development and characterization of choline and L-glutamate biosensor integrated on silicon microprobes for in-vivo monitoring.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2007, Volume: 2007

    Topics: Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Biosensing Techniques; Choline; Electrochemistr

2007
Substrate concentration and specificity of choline ester-splitting enzymes.
    Archives of biochemistry, 1949, Volume: 23, Issue:1

    Topics: Choline; Enzymes; Esters; Sensitivity and Specificity

1949
The specificity of the trimethylammonium group in acetylcholine.
    British journal of pharmacology and chemotherapy, 1949, Volume: 4, Issue:2

    Topics: Acetylcholine; Choline; Sensitivity and Specificity

1949
The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:5

    Topics: Aged; Biopsy, Needle; Choline; False Negative Reactions; Humans; Male; Middle Aged; Positron-Emissio

2008
In vivo proton spectroscopy of giant cell tumor of the bone.
    AJR. American journal of roentgenology, 2008, Volume: 190, Issue:2

    Topics: Adolescent; Adult; Biomarkers, Tumor; Bone Neoplasms; Carcinoma, Giant Cell; Child; Choline; Female;

2008
Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours.
    Nuclear medicine communications, 2008, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carbon Radioisotopes; Child; Choline; Diagnostic Errors; F

2008
Histological verification of 11C-choline-positron emission/computed tomography-positive lymph nodes in patients with biochemical failure after treatment for localized prostate cancer.
    BJU international, 2008, Volume: 102, Issue:4

    Topics: Analysis of Variance; Carbon Radioisotopes; Choline; Humans; Length of Stay; Lymph Node Excision; Ly

2008
Role of whole-body 18F-choline PET/CT in disease detection in patients with biochemical relapse after radical treatment for prostate cancer.
    La Radiologia medica, 2008, Volume: 113, Issue:6

    Topics: Aged; Biopsy; Choline; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pos

2008
Detection of choline signal in human breast lesions with chemical-shift imaging.
    Journal of magnetic resonance imaging : JMRI, 2008, Volume: 27, Issue:5

    Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium DTPA; Humans; Magnetic Re

2008
[The value of dual time point 11C-choline PET-CT in differentiating malignant from benign lesion of mediastinum].
    Zhonghua yi xue za zhi, 2007, Dec-18, Volume: 87, Issue:47

    Topics: Adult; Aged; Carbon Radioisotopes; Choline; Diagnosis, Differential; Female; Humans; Lung Neoplasms;

2007
1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders.
    Journal of child neurology, 2008, Volume: 23, Issue:7

    Topics: Adolescent; Amygdala; Analysis of Variance; Aspartic Acid; Asperger Syndrome; Autistic Disorder; Bio

2008
Quantitative proton magnetic resonance spectroscopy of the normal liver and malignant hepatic lesions at 3.0 Tesla.
    European radiology, 2008, Volume: 18, Issue:11

    Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Choline; Female; Humans; Liver; Liver Neoplasms; Magneti

2008
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
    Radiology, 1995, Volume: 197, Issue:2

    Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea

1995
AIDS dementia complex: evaluation with proton MR spectroscopic imaging.
    Radiology, 1995, Volume: 195, Issue:1

    Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Humans; Lactates; Lactic Acid; Magnetic

1995
Characterization of a phosphonium analog of choline as a probe in 31P NMR studies of phospholipid metabolism.
    NMR in biomedicine, 1994, Volume: 7, Issue:3

    Topics: Animals; Cells, Cultured; Choline; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Phos

1994
Comparison of behavioural effects of repeated treatment with methamphetamine plus scopolamine and methamphetamine alone on behavioural sensitization and conditioned response.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:10

    Topics: Animals; Behavior, Animal; Choline; Conditioning, Classical; Dopamine; Drug Synergism; Male; Methamp

1995
2-[125I]Iodomelatonin binding sites in the quail heart: characteristics, distribution and modulation by guanine nucleotides and cations.
    Life sciences, 1996, Volume: 58, Issue:13

    Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Calcium Chloride; Cell Membrane; Chol

1996
Sequential microenzymatic assay of cholesterol, triglycerides, and phospholipids in a single aliquot.
    Clinical chemistry, 1996, Volume: 42, Issue:6 Pt 1

    Topics: Animals; Cholesterol; Choline; Colorimetry; Enzymes; Glycerol; Humans; Indicators and Reagents; Mice

1996
Proton MR spectroscopy of the basal ganglia in healthy children and children with AIDS.
    Radiology, 1996, Volume: 199, Issue:2

    Topics: AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain Chemistry; Case-Control Studies; CD4 Lymp

1996
Sensitive flow-injection method with peroxyoxalate chemiluminescence detection combined with preparative high-performance liquid chromatography for determination of choline-containing phospholipids in human serum.
    Journal of chromatography. B, Biomedical applications, 1996, Apr-12, Volume: 678, Issue:2

    Topics: Choline; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Luminescent Measu

1996
Determination of choline in pharmaceutical formulations by reversed-phase high-performance liquid chromatography and postcolumn suppression conductivity detection.
    Journal of chromatography. A, 1996, Jul-19, Volume: 739, Issue:1-2

    Topics: Choline; Chromatography, High Pressure Liquid; Drug Stability; Electric Conductivity; Pharmaceutical

1996
Comparison of 3 methods for the determination of sinapic acid ester content in enzymatically treated canola meals.
    Applied microbiology and biotechnology, 1996, Volume: 45, Issue:4

    Topics: Artifacts; Brassica; Choline; Chromatography, High Pressure Liquid; Coumaric Acids; Fungal Proteins;

1996
Focal increases in [Ca2+]i may account for apparent low Ca2+ sensitivity in swine carotid artery.
    Cell calcium, 1996, Volume: 19, Issue:6

    Topics: Aequorin; Animals; Calcium; Carotid Arteries; Choline; Fluorescent Dyes; Fura-2; Histamine; Intracel

1996
An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype.
    Neuroscience letters, 1996, Aug-09, Volume: 213, Issue:3

    Topics: Acetylcholine; Animals; Choline; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Fema

1996
Evidence of differential effects produced by ethanol on specific phospholipid biosynthetic pathways in rat hepatocytes.
    British journal of pharmacology, 1996, Volume: 119, Issue:2

    Topics: Alcohol Dehydrogenase; Animals; Carbon Radioisotopes; Cells, Cultured; Choline; Enzyme Inhibitors; E

1996
Lactate, N-acetylaspartate, choline and creatine concentrations, and spin-spin relaxation in thalamic and occipito-parietal regions of developing human brain.
    Magnetic resonance in medicine, 1996, Volume: 36, Issue:6

    Topics: Aspartic Acid; Brain Chemistry; Choline; Creatine; Gestational Age; Humans; Infant; Infant, Newborn;

1996
Amperometric microsensors for monitoring choline in the extracellular fluid of brain.
    Journal of neuroscience methods, 1996, Volume: 70, Issue:1

    Topics: Acetylcholine; Alcohol Oxidoreductases; Animals; Biosensing Techniques; Brain Chemistry; Choline; Ch

1996
Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment.
    Magnetic resonance in medicine, 1997, Volume: 37, Issue:6

    Topics: Alanine; Aspartic Acid; Brain; Choline; Creatine; gamma-Aminobutyric Acid; Humans; Inositol; Magneti

1997
Brain tumors: localized H-1 MR spectroscopy at 0.5 T.
    Radiology, 1997, Volume: 204, Issue:1

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Case-Control Studi

1997
Fine-needle biopsy specimens of benign breast lesions distinguished from invasive cancer ex vivo with proton MR spectroscopy.
    Radiology, 1997, Volume: 204, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Biopsy, Needle; Breast; Breast Neoplasms; Carcinoma in Situ; Carcino

1997
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
    Acta radiologica (Stockholm, Sweden : 1987), 1997, Volume: 38, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo

1997
Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 1998, Volume: 39, Issue:1

    Topics: Adult; Aspartic Acid; Body Water; Choline; Creatine; Humans; Image Enhancement; Magnetic Resonance S

1998
Isolation and quantitation of phosphatidylcholine by reversed-phase liquid-liquid extraction.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Dec-05, Volume: 703, Issue:1-2

    Topics: Acetic Acid; Calibration; Choline; Chromatography, Liquid; Colorimetry; Humans; Linear Models; Osmol

1997
Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV.
    Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 64, Issue:4

    Topics: Adolescent; Adult; AIDS Dementia Complex; Aspartic Acid; Case-Control Studies; Choline; Creatine; Di

1998
Serial precision of metabolite peak area ratios and water referenced metabolite peak areas in proton MR spectroscopy of the human brain.
    Magnetic resonance imaging, 1998, Volume: 16, Issue:3

    Topics: Adult; Aspartic Acid; Body Water; Brain; Choline; Creatine; Energy Metabolism; Equipment Design; Fem

1998
Fast 1H spectroscopic imaging using a multi-element head-coil array.
    Magnetic resonance in medicine, 1998, Volume: 40, Issue:2

    Topics: Aspartic Acid; Brain; Choline; Creatine; Equipment Design; Humans; Magnetic Resonance Imaging; Magne

1998
Acetylcholine in human CSF: methodological considerations and levels in dementia of Alzheimer type.
    Journal of neural transmission (Vienna, Austria : 1996), 1998, Volume: 105, Issue:8-9

    Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Choline; Chromatography, High Pressure Li

1998
Mapping brain metabolites using a double echo-filter metabolite imaging (DEFMI) technique.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 1999, Volume: 140, Issue:2

    Topics: Aspartic Acid; Body Water; Brain; Choline; Creatine; Humans; Image Processing, Computer-Assisted; La

1999
Positron emission tomography of esophageal carcinoma using (11)C-choline and (18)F-fluorodeoxyglucose: a novel method of preoperative lymph node staging.
    Cancer, 1999, Nov-01, Volume: 86, Issue:9

    Topics: Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Esophageal Neoplasms; Female; Fluorodeoxyglu

1999
Effect of voxel position on single-voxel MR spectroscopy findings.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2

    Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio

2000
Discrimination between neoplastic and nonneoplastic brain lesions by use of proton MR spectroscopy: the limits of accuracy with a logistic regression model.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosi

2000
Sensitive detection of mediastinal lymph node metastasis of lung cancer with 11C-choline PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000, Volume: 41, Issue:9

    Topics: Adult; Aged; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Choline; Female; Fluorodeoxygluco

2000
MR spectroscopic imaging of normal-appearing white matter in adrenoleukodystrophy.
    Pediatric radiology, 2000, Volume: 30, Issue:9

    Topics: Adolescent; Adrenoleukodystrophy; Adult; Age Factors; Brain; Child; Choline; Data Interpretation, St

2000
Alkyldimethylaminoethyl ester iodides for improved analysis of fatty acids by electrospray ionization tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2000, Volume: 14, Issue:21

    Topics: Adult; Alkylation; Amino Acids; Choline; Dicarboxylic Acids; Esters; Fatty Acids; Fatty Acids, Unsat

2000
Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2001, Volume: 60, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Fem

2001
Pharmacological evidence for the selectivity of in vivo signals obtained with enzyme-based electrochemical sensors.
    Journal of neuroscience methods, 2001, Jan-15, Volume: 104, Issue:2

    Topics: Animals; Choline; Corpus Striatum; Electrochemistry; Glucose; Injections, Intraventricular; Male; Mi

2001
A novel method to analyze betaine in chicken liver: effect of dietary betaine and choline supplementation on the hepatic betaine concentration in broiler chicks.
    Journal of agricultural and food chemistry, 2001, Volume: 49, Issue:2

    Topics: Animal Feed; Animals; Betaine; Chickens; Choline; Chromatography, High Pressure Liquid; Chromatograp

2001
Lateralizing ability of single-voxel proton mr spectroscopy in hippocampal sclerosis: comparison with mr imaging and positron emission tomography.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Choline; Dominance, Cerebral; Energy Metabolism; Epilepsy, Tempora

2001
Evaluation of female intrapelvic tumors by clinical proton MR spectroscopy.
    Journal of magnetic resonance imaging : JMRI, 2001, Volume: 13, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Choline; Creatine; Diagnosis, Differential; Energy Metabolism; Femal

2001
Carnitine alters binding of aflatoxin to DNA and proteins in rat hepatocytes and cell-free systems.
    The Journal of nutrition, 2001, Volume: 131, Issue:7

    Topics: Aflatoxin B1; Animals; Biomarkers; Carnitine; Cells, Cultured; Choline; DNA Adducts; Dose-Response R

2001
An acetylcholinesterase/choline oxidase-based amperometric biosensors as a liquid chromatography detector for acetylcholine and choline determination in brain tissue homogenates.
    Analytical chemistry, 2001, Jul-01, Volume: 73, Issue:13

    Topics: Acetylcholine; Acetylcholinesterase; Alcohol Oxidoreductases; Animals; Biosensing Techniques; Brain

2001
The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy.
    Breast cancer research and treatment, 2001, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma,

2001
Carbon-11 choline or FDG-PET for staging of oesophageal cancer?
    European journal of nuclear medicine, 2001, Volume: 28, Issue:12

    Topics: Carbon Radioisotopes; Choline; Esophageal Neoplasms; Feasibility Studies; Female; Fluorodeoxyglucose

2001
[1H-MR Spectroscopy of brain tumors in the course of radiation therapy: Use of fast spectroscopic imaging and single-voxel spectroscopy for diagnosing recurrence].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2002, Volume: 174, Issue:1

    Topics: Adult; Aged; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Cranial Irradiation; Energy

2002
Picoliter (1)H NMR spectroscopy.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 2002, Volume: 154, Issue:2

    Topics: Animals; Anura; Choline; Feasibility Studies; Magnetic Resonance Spectroscopy; Sensitivity and Speci

2002
Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer.
    The Journal of urology, 2002, Volume: 168, Issue:1

    Topics: Animals; Choline; Fluorine Compounds; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Male;

2002
Repeated antigen challenge induced airway hyperresponsiveness to neurokinin A and vagal non-adrenergic, non-cholinergic (NANC) stimulation in guinea pigs.
    Life sciences, 1992, Volume: 51, Issue:11

    Topics: Acetylcholine; Aerosols; Animals; Antigens; Bronchial Hyperreactivity; Capsaicin; Choline; Disease M

1992