choline has been researched along with Schizophrenia in 130 studies
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choline is elevated in the basal ganglia and prefrontal cortical regions, suggesting regionally increased membrane turnover or glial activation in schizophrenia." | 9.41 | Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. ( Maddock, RJ; Smucny, J; Yang, YS; Zhang, H, 2023) |
| "The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride." | 9.04 | Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. ( Berger, PA; Davis, KL, 1978) |
| "To examine glutamine, glutamate, and glutamine to glutamate ratio in the dorsal anterior cingulate, as well as their relationships with symptoms and cognition in schizophrenia." | 7.80 | Increased glutamine in patients undergoing long-term treatment for schizophrenia: a proton magnetic resonance spectroscopy study at 3 T. ( Abbott, C; Bustillo, JR; Canive, J; Chen, H; Gasparovic, C; Jones, T; Lemke, N; Qualls, C, 2014) |
| " In particular, clozapine appears to act more selectively than typical antipsychotics on the prefrontal region, an area of special relevance in higher cognitive functions and schizophrenia." | 7.74 | The effect of clozapine on neuroimaging findings in schizophrenia. ( Ertugrul, A; Uluğ, B, 2007) |
| "High caudate choline levels in schizophrenia are not secondary to antipsychotic treatment." | 7.71 | High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophrenia. ( Brooks, WM; Bustillo, JR; Hammond, R; Hart, B; Lauriello, J; Petropoulos, H; Rowland, LM, 2002) |
| "Davunetide is a neurotrophic peptide that can enhance cognitive function in animal models of neurodegeneration." | 6.78 | Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia. ( Barch, DM; Buchanan, RW; Colibazzi, T; Csernansky, JG; Dong, Z; Girgis, RR; Goff, DC; Harms, MP; Jarskog, LF; Javitt, DC; Kangarlu, A; Keefe, RS; Kegeles, LS; Lieberman, JA; Marder, SR; McEvoy, JP; McMahon, RP; Peterson, BS, 2013) |
| "Choline is elevated in the basal ganglia and prefrontal cortical regions, suggesting regionally increased membrane turnover or glial activation in schizophrenia." | 5.41 | Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. ( Maddock, RJ; Smucny, J; Yang, YS; Zhang, H, 2023) |
| "The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride." | 5.04 | Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. ( Berger, PA; Davis, KL, 1978) |
| "Eleven metabolites were significantly altered in AP-induced constipation which primarily disturbed sphingolipid metabolism, choline metabolism, and sphingolipid signaling pathway (P value < ." | 4.31 | Serum Metabolic Profile in Schizophrenia Patients With Antipsychotic-Induced Constipation and Its relationship With Gut Microbiome. ( Amdanee, N; Chen, J; Fang, X; Hu, X; Pan, X; Ridwan Chattun, M; Shao, M; Wen, L; Xu, Y; Zhang, X; Zhou, C, 2023) |
| "To further investigate this possibility, we undertook a lipidomics analysis of choline and ethanolamine plasmalogens in the plasma and platelets of 23 patients with schizophrenia and 27 age-matched controls." | 3.81 | Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia. ( Phillipps, A; Unfried, G; Whitehead, W; Wood, JA; Wood, PL, 2015) |
| "To examine glutamine, glutamate, and glutamine to glutamate ratio in the dorsal anterior cingulate, as well as their relationships with symptoms and cognition in schizophrenia." | 3.80 | Increased glutamine in patients undergoing long-term treatment for schizophrenia: a proton magnetic resonance spectroscopy study at 3 T. ( Abbott, C; Bustillo, JR; Canive, J; Chen, H; Gasparovic, C; Jones, T; Lemke, N; Qualls, C, 2014) |
| "The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia." | 3.80 | The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7. ( Freedman, R; Indersmitten, T; Leonard, S; Lester, HA; Wang, Y; Xiao, C, 2014) |
| "Imaging studies of schizophrenia patients showed fronto-temporal brain volume deficits, while magnetic resonance spectroscopy (MRS) studies of patients and unaffected biological relatives have found a decrement of the neuronal marker N-acetyl-aspartate (NAA) in the hippocampus and frontal lobes, and increased choline-containing phospholipids." | 3.77 | Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands. ( Capizzano, AA; Ho, BC; Toscano, JL, 2011) |
| " In particular, clozapine appears to act more selectively than typical antipsychotics on the prefrontal region, an area of special relevance in higher cognitive functions and schizophrenia." | 3.74 | The effect of clozapine on neuroimaging findings in schizophrenia. ( Ertugrul, A; Uluğ, B, 2007) |
| "Compared to controls, schizophrenia and bipolar patients presented decreased NAA to creatine ratios, while only the schizophrenia group showed an increase in CSF in the dorsolateral prefrontal region." | 3.74 | Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder. ( Benito, C; Desco, M; Leal, I; Molina, V; Palomo, T; Rebolledo, R; Reig, S; Sánchez, J; Sanz, J; Sarramea, F, 2007) |
| "Choline and NAA ratio abnormalities determined by thalamic spectroscopy may be related to the pathogenesis of auditory hallucinations in patients with schizophrenia." | 3.74 | Spectroscopic metabolomic abnormalities in the thalamus related to auditory hallucinations in patients with schizophrenia. ( Aguilar, EJ; Brotons, O; Celda, B; González, JC; Martí-Bonmati, L; Martínez-Bisbal, MC; Martínez-Granados, B; Sanjuán, J, 2008) |
| "In the anterior cingulate gyrus, patients with schizophrenia and GS showed significant decreases in N-acetyl aspartate/creatine-phosphocreatinine (NAA/Cr), choline/creatine-phosphocreatinine (Cho/Cr) and myoinositol/creatine-phosphocreatinine (ml/Cr) ratios compared with healthy subjects and compared with patients with schizophrenia without GS." | 3.73 | Proton magnetic resonance spectroscopy of the anterior cingulate gyrus, insular cortex and thalamus in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome). ( Horiguchi, J; Inagaki, T; Kitagaki, H; Miyaoka, T; Mizuno, S; Oda, K; Yasukawa, R, 2005) |
| "We used in vivo proton magnetic resonance spectroscopic imaging ((1)H MRSI) to measure N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine+phosphocreatine (Cr) in the mediodorsal and anterior thalamus in 22 male patients with schizophrenia and 22 male controls." | 3.73 | N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI. ( Deicken, RF; Feiwell, R; Jakary, A; Vinogradov, S, 2005) |
| " Thalamic and white matter metabolite concentrations (myo-inositol (mI), choline-containing compounds (Cho), total creatine (Cr) and N-acetylaspartate (NAA)) were estimated and corrected for atrophy (CSF) and gray and white matter contributions (GM, WM) by use of image-based voxel segmentation." | 3.71 | Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation. ( Auer, DP; Bronisch, T; Grabner, A; Heidenreich, JO; Wetter, TC; Wilke, M, 2001) |
| "High caudate choline levels in schizophrenia are not secondary to antipsychotic treatment." | 3.71 | High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophrenia. ( Brooks, WM; Bustillo, JR; Hammond, R; Hart, B; Lauriello, J; Petropoulos, H; Rowland, LM, 2002) |
| "Acetylcholinesterase (AChE) was measured in the cerebrospinal fluid (CSF) of patients with a diagnosis of Huntington's disease, depression, schizophrenia, or mania and also in the CSF of normal subjects." | 3.66 | Cerebrospinal fluid acetylcholinesterase in neuropsychiatric disorders. ( Berger, PA; Davis, KL; Hollister, LE; Livesey, J, 1979) |
| "Davunetide is a neurotrophic peptide that can enhance cognitive function in animal models of neurodegeneration." | 2.78 | Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia. ( Barch, DM; Buchanan, RW; Colibazzi, T; Csernansky, JG; Dong, Z; Girgis, RR; Goff, DC; Harms, MP; Jarskog, LF; Javitt, DC; Kangarlu, A; Keefe, RS; Kegeles, LS; Lieberman, JA; Marder, SR; McEvoy, JP; McMahon, RP; Peterson, BS, 2013) |
| "We studied 32 minimally treated schizophrenia patients and 21 healthy subjects with single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) of the frontal and occipital lobes, caudate nucleus, and cerebellum." | 2.73 | Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophrenia. ( Brooks, WM; Bustillo, JR; Hammond, R; Hart, B; Jung, R; Lauriello, J; Qualls, C; Rowland, LM, 2008) |
| "Namely, core schizophrenia is characterized by a left-temporal dysfunction associated with deficits in verbal processing." | 2.41 | The neurophysiological meaning of auditory P300 in subtypes of schizophrenia. ( Kalus, P; Müller, TJ; Strik, WK, 2001) |
| "Huntington's chorea, ataxias, Tourette's syndrome, schizophrenia, affective illness, and senile dementia of the Alzheimer type, has been implicated with a general underactivity of central cholinergic mechanisms." | 2.36 | The use of cholinergic precursors in neuropsychiatric diseases. ( Davis, KL; Rosenberg, GS, 1982) |
| "Schizophrenia is a chronic, often progressive, disorder." | 1.48 | Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients. ( Gonzales, SS; Kraguljac, NV; Lahti, AC; Morgan, CJ; Sivaraman, S; White, DM, 2018) |
| "Schizophrenia is well-known to be associated with hippocampal structural abnormalities." | 1.43 | Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T. ( Babb, JS; Davitz, MS; Gonen, O; Kirov, II; Lazar, M; Malaspina, D; Meyer, EJ; Tal, A, 2016) |
| "Schizophrenia is characterized by loss of brain volume, which may represent an ongoing pathophysiological process." | 1.40 | GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study. ( Andreychenko, A; Boer, VO; Bohlken, MM; Cahn, W; Hulshoff Pol, HE; Kahn, RS; Klomp, DW; Luijten, PR; Mandl, RC; Marsman, A, 2014) |
| "Auditory hallucinations are one of the central symptoms in schizophrenia." | 1.40 | Study of the inferior colliculus in patients with schizophrenia by magnetic resonance spectroscopy. ( Aguilar, EJ; Celda, B; Marti-Bonmati, L; Martinez-Bisbal, MC; Martinez-Granados, B; Molla, E; Sanjuan, J, 2014) |
| "Cannabis abuse has been related to an earlier onset of the disease and persisting cannabis consumption is associated with reduced symptom improvement." | 1.39 | Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia. ( Falkai, P; Gruber, O; Hasan, A; Jatzko, A; Malchow, B; Schmitt, A; Schneider-Axmann, T; Wobrock, T, 2013) |
| "Sixty-three first-episode treatment-naïve schizophrenia (FES) patients and 63 age-, gender- and education level-matched healthy controls were recruited." | 1.38 | Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first-episode treatment-naïve schizophrenia patients. ( Chen, ZF; Collier, DA; Deng, W; He, ZL; Li, ML; Li, T; Ma, X, 2012) |
| "Schizophrenia is associated with significant brain abnormalities, including changes in brain metabolites as measured by proton magnetic resonance spectroscopy (MRS)." | 1.35 | A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis. ( Berger, GE; McConchie, M; McGorry, PD; Pantelis, C; Proffitt, T; Velakoulis, D; Wellard, RM; Wood, SJ, 2008) |
| "Schizophrenia is a disorder with an unclear pathophysiology, despite numerous attempts to elucidate its etiology." | 1.30 | Regional proton magnetic resonance spectroscopy in schizophrenia and exploration of drug effect. ( Cardwell, D; Heimberg, C; Karson, CN; Komoroski, RA; Lawson, WB, 1998) |
| " The chlorpromazine equivalent neuroleptic dosage was positively correlated with the level of NAA (r = 0." | 1.29 | Proton magnetic resonance spectroscopy of the basal ganglia in patients with schizophrenia: a preliminary report. ( Fujii, K; Hamakawa, H; Inubushi, T; Kato, T; Murashita, J; Shioiri, T; Takahashi, S, 1996) |
| "RBC choline concentration was significantly lower in patients medicated with neuroleptics and cogentin." | 1.28 | RBC and plasma choline in neuroleptic-treated schizophrenic patients. ( Hanin, I; Jeste, DV; Kopp, U; Lawson, WB; Wyatt, RJ, 1989) |
| "Glycine levels in RBC were also significantly higher in patients on Li+ compared to normals or Li+ free affective disorder patients." | 1.26 | Elevation of choline and glycine in red blood cells of psychiatric patients due to lithium treatment. ( Hendrie, HC; Shea, PA; Small, JG, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (16.15) | 18.7374 |
| 1990's | 20 (15.38) | 18.2507 |
| 2000's | 46 (35.38) | 29.6817 |
| 2010's | 36 (27.69) | 24.3611 |
| 2020's | 7 (5.38) | 2.80 |
| Authors | Studies |
|---|---|
| Smucny, J | 2 |
| Carter, CS | 1 |
| Maddock, RJ | 2 |
| Amdanee, N | 1 |
| Shao, M | 1 |
| Hu, X | 1 |
| Fang, X | 1 |
| Zhou, C | 1 |
| Chen, J | 1 |
| Ridwan Chattun, M | 1 |
| Wen, L | 1 |
| Pan, X | 1 |
| Zhang, X | 1 |
| Xu, Y | 1 |
| Yang, YS | 1 |
| Zhang, H | 1 |
| Whitehurst, TS | 1 |
| Osugo, M | 1 |
| Townsend, L | 1 |
| Shatalina, E | 1 |
| Vava, R | 1 |
| Onwordi, EC | 1 |
| Howes, O | 1 |
| Malaspina, D | 3 |
| Lotan, E | 1 |
| Rusinek, H | 1 |
| Perez, SA | 1 |
| Walsh-Messinger, J | 1 |
| Kranz, TM | 1 |
| Gonen, O | 3 |
| Dutta, A | 1 |
| Karanth, SS | 1 |
| Bhattacharya, M | 1 |
| Liput, M | 1 |
| Augustyniak, J | 1 |
| Cheung, M | 1 |
| Stachowiak, EK | 1 |
| Stachowiak, MK | 1 |
| Aidelbaum, R | 1 |
| Labelle, A | 1 |
| Choueiry, J | 1 |
| Knott, V | 1 |
| Molins, C | 1 |
| Carceller-Sindreu, M | 1 |
| Navarro, H | 1 |
| Carmona, C | 1 |
| Piñeiro, M | 1 |
| Martínez, E | 1 |
| Álvarez, E | 1 |
| Portella, MJ | 1 |
| Plitman, E | 2 |
| Chavez, S | 2 |
| Nakajima, S | 1 |
| Iwata, Y | 1 |
| Chung, JK | 1 |
| Caravaggio, F | 1 |
| Kim, J | 1 |
| Alshehri, Y | 1 |
| Chakravarty, MM | 1 |
| De Luca, V | 1 |
| Remington, G | 1 |
| Gerretsen, P | 1 |
| Graff-Guerrero, A | 2 |
| He, Y | 1 |
| Kosciolek, T | 1 |
| Tang, J | 1 |
| Zhou, Y | 1 |
| Li, Z | 1 |
| Ma, X | 2 |
| Zhu, Q | 1 |
| Yuan, N | 1 |
| Yuan, L | 1 |
| Li, C | 1 |
| Jin, K | 1 |
| Knight, R | 1 |
| Tsuang, MT | 1 |
| Chen, X | 2 |
| Sivaraman, S | 1 |
| Kraguljac, NV | 1 |
| White, DM | 1 |
| Morgan, CJ | 1 |
| Gonzales, SS | 1 |
| Lahti, AC | 1 |
| Sekar, S | 1 |
| Grandjean, J | 1 |
| Garnell, JF | 1 |
| Willems, R | 1 |
| Duytschaever, H | 1 |
| Seramani, S | 1 |
| Su, H | 1 |
| Ver Donck, L | 1 |
| Bhakoo, KK | 1 |
| Lewandowski, KE | 1 |
| Du, F | 1 |
| Fan, X | 1 |
| Huynh, P | 1 |
| Öngür, D | 2 |
| Rapoport, JL | 2 |
| Granata, F | 1 |
| Pandolfo, G | 1 |
| Vinci, S | 1 |
| Alafaci, C | 1 |
| Settineri, N | 1 |
| Morabito, R | 1 |
| Pitrone, A | 1 |
| Longo, M | 1 |
| Malchow, B | 1 |
| Hasan, A | 1 |
| Schneider-Axmann, T | 2 |
| Jatzko, A | 1 |
| Gruber, O | 2 |
| Schmitt, A | 1 |
| Falkai, P | 4 |
| Wobrock, T | 2 |
| Bustillo, JR | 4 |
| Chen, H | 2 |
| Jones, T | 2 |
| Lemke, N | 2 |
| Abbott, C | 3 |
| Qualls, C | 3 |
| Canive, J | 2 |
| Gasparovic, C | 2 |
| Stevens, KE | 5 |
| Choo, KS | 1 |
| Stitzel, JA | 2 |
| Marks, MJ | 1 |
| Adams, CE | 3 |
| Gan, JL | 1 |
| Cheng, ZX | 1 |
| Duan, HF | 1 |
| Yang, JM | 1 |
| Zhu, XQ | 1 |
| Gao, CY | 1 |
| Martinez-Granados, B | 2 |
| Martinez-Bisbal, MC | 2 |
| Sanjuan, J | 2 |
| Aguilar, EJ | 2 |
| Marti-Bonmati, L | 2 |
| Molla, E | 1 |
| Celda, B | 2 |
| Wang, Y | 2 |
| Xiao, C | 1 |
| Indersmitten, T | 1 |
| Freedman, R | 4 |
| Leonard, S | 3 |
| Lester, HA | 1 |
| Marsman, A | 1 |
| Mandl, RC | 1 |
| Klomp, DW | 1 |
| Bohlken, MM | 1 |
| Boer, VO | 1 |
| Andreychenko, A | 1 |
| Cahn, W | 1 |
| Kahn, RS | 1 |
| Luijten, PR | 1 |
| Hulshoff Pol, HE | 1 |
| Wood, PL | 1 |
| Unfried, G | 1 |
| Whitehead, W | 1 |
| Phillipps, A | 1 |
| Wood, JA | 1 |
| Wu, WL | 1 |
| Chow, KH | 1 |
| Patterson, PH | 1 |
| Zheng, L | 1 |
| Floyd, KL | 1 |
| Chiappelli, J | 1 |
| Hong, LE | 1 |
| Wijtenburg, SA | 1 |
| Du, X | 1 |
| Gaston, F | 1 |
| Kochunov, P | 1 |
| Rowland, LM | 4 |
| Strzelecki, D | 1 |
| Podgórski, M | 1 |
| Kałużyńska, O | 1 |
| Gawlik-Kotelnicka, O | 1 |
| Stefańczyk, L | 1 |
| Kotlicka-Antczak, M | 1 |
| Gmitrowicz, A | 1 |
| Grzelak, P | 1 |
| de la Fuente-Sandoval, C | 1 |
| Reyes-Madrigal, F | 1 |
| Gómez-Cruz, G | 1 |
| León-Ortiz, P | 1 |
| Brandt, AS | 1 |
| Unschuld, PG | 1 |
| Pradhan, S | 1 |
| Lim, IA | 1 |
| Churchill, G | 1 |
| Harris, AD | 1 |
| Hua, J | 1 |
| Barker, PB | 1 |
| Ross, CA | 1 |
| van Zijl, PC | 1 |
| Edden, RA | 1 |
| Margolis, RL | 1 |
| Meyer, EJ | 1 |
| Kirov, II | 1 |
| Tal, A | 2 |
| Davitz, MS | 1 |
| Babb, JS | 2 |
| Lazar, M | 1 |
| Kirtaş, D | 1 |
| Karadağ, RF | 1 |
| Balci Şengül, MC | 1 |
| Kiroğlu, Y | 1 |
| Stromberg, S | 1 |
| Browne, A | 1 |
| Jakary, A | 2 |
| Vinogradov, S | 3 |
| Fu, Y | 1 |
| Deicken, RF | 6 |
| Brotons, O | 1 |
| González, JC | 1 |
| Scherk, H | 2 |
| Backens, M | 1 |
| Zill, P | 1 |
| Usher, J | 1 |
| Reith, W | 1 |
| Möller, HJ | 1 |
| Bondy, B | 1 |
| Sellin, AK | 1 |
| Shad, M | 1 |
| Tamminga, C | 1 |
| Tayoshi, S | 1 |
| Sumitani, S | 1 |
| Taniguchi, K | 1 |
| Shibuya-Tayoshi, S | 1 |
| Numata, S | 1 |
| Iga, J | 1 |
| Nakataki, M | 1 |
| Ueno, S | 1 |
| Harada, M | 1 |
| Ohmori, T | 1 |
| Sanches, RF | 1 |
| Crippa, JA | 1 |
| Hallak, JE | 1 |
| de Sousa, JP | 1 |
| Araújo, D | 1 |
| Santos, AC | 1 |
| Zuardi, AW | 1 |
| Yoo, SY | 1 |
| Yeon, S | 1 |
| Choi, CH | 1 |
| Kang, DH | 1 |
| Lee, JM | 1 |
| Shin, NY | 1 |
| Jung, WH | 1 |
| Choi, JS | 1 |
| Jang, DP | 1 |
| Kwon, JS | 1 |
| Chang, HM | 1 |
| Qi, ST | 1 |
| Yang, KJ | 1 |
| Wang, KW | 1 |
| Guo, ZW | 1 |
| Wang, H | 1 |
| Prescot, AP | 1 |
| Jensen, JE | 2 |
| Rouse, ED | 1 |
| Cohen, BM | 3 |
| Renshaw, PF | 3 |
| Olson, DP | 1 |
| Ross, RG | 2 |
| Proctor, WR | 1 |
| Kisley, MA | 1 |
| Hunter, SK | 2 |
| Premkumar, P | 1 |
| Parbhakar, VA | 1 |
| Fannon, D | 1 |
| Lythgoe, D | 1 |
| Williams, SC | 2 |
| Kuipers, E | 1 |
| Kumari, V | 1 |
| Uhl, I | 1 |
| Mavrogiorgou, P | 1 |
| Norra, C | 1 |
| Forstreuter, F | 1 |
| Scheel, M | 1 |
| Witthaus, H | 1 |
| Ozgürdal, S | 1 |
| Gudlowski, Y | 1 |
| Bohner, G | 1 |
| Gallinat, J | 1 |
| Klingebiel, R | 1 |
| Heinz, A | 1 |
| Juckel, G | 1 |
| Capizzano, AA | 1 |
| Toscano, JL | 1 |
| Ho, BC | 1 |
| Hardy, CJ | 1 |
| Perry, NN | 1 |
| Messinger, JW | 1 |
| Antonius, D | 1 |
| He, ZL | 1 |
| Deng, W | 1 |
| Li, ML | 1 |
| Chen, ZF | 1 |
| Collier, DA | 1 |
| Li, T | 1 |
| Jia, YB | 1 |
| Ling, XY | 1 |
| Zhong, SM | 1 |
| Huang, L | 1 |
| Corriveau, JA | 1 |
| Glenn, MJ | 1 |
| McCarthy, L | 1 |
| Beuler, J | 1 |
| Hutchison, AK | 1 |
| Wagner, BD | 1 |
| Jarskog, LF | 1 |
| Dong, Z | 1 |
| Kangarlu, A | 1 |
| Colibazzi, T | 1 |
| Girgis, RR | 1 |
| Kegeles, LS | 1 |
| Barch, DM | 1 |
| Buchanan, RW | 1 |
| Csernansky, JG | 1 |
| Goff, DC | 1 |
| Harms, MP | 1 |
| Javitt, DC | 1 |
| Keefe, RS | 1 |
| McEvoy, JP | 1 |
| McMahon, RP | 1 |
| Marder, SR | 1 |
| Peterson, BS | 1 |
| Lieberman, JA | 1 |
| Moore, CM | 1 |
| Bonello, CM | 1 |
| Sherwood, AR | 1 |
| Yurgulen-Todd, DA | 1 |
| Ando, K | 1 |
| Takei, N | 1 |
| Matsumoto, H | 1 |
| Iyo, M | 1 |
| Isoda, H | 1 |
| Mori, N | 1 |
| Yamasue, H | 2 |
| Fukui, T | 2 |
| Fukuda, R | 2 |
| Yamada, H | 1 |
| Yamasaki, S | 1 |
| Kuroki, N | 1 |
| Abe, O | 1 |
| Kasai, K | 2 |
| Tsujii, K | 1 |
| Iwanami, A | 2 |
| Aoki, S | 1 |
| Ohtomo, K | 1 |
| Kato, N | 2 |
| Kato, T | 3 |
| Müller, TJ | 1 |
| Kalus, P | 1 |
| Strik, WK | 1 |
| Ende, G | 3 |
| Braus, DF | 3 |
| Walter, S | 2 |
| Weber-Fahr, W | 2 |
| Henn, FA | 3 |
| TAKAHASHI, Y | 1 |
| OGUSHI, T | 1 |
| BARUCCI, M | 1 |
| MORI, F | 1 |
| Sigmundsson, T | 1 |
| Maier, M | 2 |
| Toone, BK | 1 |
| Simmons, A | 1 |
| Greenwood, K | 1 |
| Ron, MA | 2 |
| POLONI, A | 1 |
| Wood, SJ | 3 |
| Berger, G | 1 |
| Velakoulis, D | 3 |
| Phillips, LJ | 1 |
| McGorry, PD | 3 |
| Yung, AR | 1 |
| Desmond, P | 2 |
| Pantelis, C | 3 |
| O'Neill, J | 1 |
| Levitt, J | 1 |
| Caplan, R | 1 |
| Asarnow, R | 1 |
| McCracken, JT | 1 |
| Toga, AW | 1 |
| Alger, JR | 1 |
| Théberge, J | 2 |
| Al-Semaan, Y | 1 |
| Drost, DJ | 1 |
| Malla, AK | 1 |
| Neufeld, RW | 1 |
| Bartha, R | 1 |
| Manchanda, R | 1 |
| Menon, R | 1 |
| Densmore, M | 1 |
| Schaefer, B | 1 |
| Williamson, PC | 1 |
| Molina, V | 2 |
| Sánchez, J | 2 |
| Reig, S | 2 |
| Sanz, J | 2 |
| Benito, C | 2 |
| Santamarta, C | 1 |
| Pascau, J | 1 |
| Sarramea, F | 2 |
| Gispert, JD | 1 |
| Misiego, JM | 1 |
| Palomo, T | 2 |
| Desco, M | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study on Predictiors and Mechanism of Conversion to Psychosis in Individuals at Ultra-high Risk Group[NCT03965598] | 200 participants (Anticipated) | Observational | 2016-11-01 | Recruiting | |||
| Glutamate, Brain Connectivity and Duration of Untreated Psychosis[NCT02034253] | 134 participants (Actual) | Observational | 2014-01-31 | Completed | |||
| Effect of Sarcosine on Symptomatology, Quality of Life, Cognitive and Sexual Functioning, Blood Levels of Sarcosine, Glycine, BDNF and MMP-9, Oculomotor, Brain Metabolism and Oxidative Stress Parameters in Schizophrenia.[NCT01503359] | Phase 2 | 70 participants (Anticipated) | Interventional | 2012-01-31 | Completed | ||
| Double-blind Trial of Phosphatidylcholine During Pregnancy and Infant Serum Choline Levels[NCT00332124] | Phase 1 | 351 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis[NCT05282277] | Phase 4 | 103 participants (Anticipated) | Interventional | 2022-04-20 | Recruiting | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
11 reviews available for choline and Schizophrenia
| Article | Year |
|---|---|
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Schizophr | 2023 |
Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis.
Topics: Aspartic Acid; Choline; Humans; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizop | 2020 |
Muscarinic agonists for the treatment of cognition in schizophrenia.
Topics: Animals; Antipsychotic Agents; Choline; Cognition Disorders; Disease Models, Animal; Humans; Muscari | 2008 |
Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Choline; Disease Models, Animal; Evoked Pot | 2010 |
The neurophysiological meaning of auditory P300 in subtypes of schizophrenia.
Topics: Arousal; Choline; Dopamine; Event-Related Potentials, P300; Evoked Potentials, Auditory; Functional | 2001 |
N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration.
Topics: Adult; Age Factors; Antipsychotic Agents; Aspartic Acid; Choline; Chronic Disease; Creatine; Female; | 2005 |
What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update.
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Cross-Over Studies; Glutamic Acid; Glutamine; H | 2006 |
[Cholinergic hypothesis in psychosis following traumatic brain injury and cholinergic hypothesis in schizophrenia: a link?].
Topics: Brain Injuries; Choline; Humans; Psychotic Disorders; Schizophrenia | 2007 |
The use of cholinergic precursors in neuropsychiatric diseases.
Topics: Acetylcholine; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Cerebellar Ataxia; Choline; Huma | 1982 |
Glycine: a possible role in lithium's action and affective illness.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Autistic Disorder; Bipolar Disorder; Brain Chemistry; | 1983 |
Proton magnetic resonance spectroscopy of the human brain in schizophrenia.
Topics: Aspartic Acid; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectr | 2000 |
13 trials available for choline and Schizophrenia
| Article | Year |
|---|---|
The acute dose and baseline amplitude-dependent effects of CDP-choline on deviance detection (MMN) in chronic schizophrenia: A pilot study.
Topics: Choline; Cytidine Diphosphate Choline; Electroencephalography; Evoked Potentials; Humans; Pilot Proj | 2022 |
Supplementation of antipsychotic treatment with sarcosine – GlyT1 inhibitor – causes changes of glutamatergic (1)NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Double-Blind Method; Fema | 2015 |
Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Attention; Brain; Child, Preschool; Choline; DNA Mutational | 2013 |
Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Choline; Cognition; Creatine; Female; Functi | 2013 |
The effect of risperidone on metabolite measures in the frontal lobe, temporal lobe, and thalamus in schizophrenic patients. A proton magnetic resonance spectroscopy (1H MRS).
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Energy Metabolism; Female; Frontal Lo | 2005 |
[Comparison of right thalamus and temporal cortex metabolite levels of drug-naive first-episode psychotic and chronic schizophrenia in patients].
Topics: Aspartic Acid; Case-Control Studies; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Mal | 2006 |
Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Choli | 2008 |
Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia.
Topics: Acetylation; Adult; Brain Chemistry; Choline; Creatine; Female; Hippocampus; Humans; Magnetic Resona | 1998 |
Regionally specific neuronal pathology in untreated patients with schizophrenia: a proton magnetic resonance spectroscopic imaging study.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Hippocampus; Humans; Magnet | 1998 |
Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype.
Topics: Adult; Aspartic Acid; Biomarkers; Choline; Creatine; Family; Female; Hippocampus; Humans; Magnetic R | 1998 |
A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia.
Topics: Adult; Algorithms; Aspartic Acid; Choline; Creatine; Female; Hippocampus; Humans; Image Processing, | 2002 |
Choline chloride in schizophrenia.
Topics: Adult; Brief Psychiatric Rating Scale; Choline; Depression; Drug Evaluation; Humans; Male; Middle Ag | 1979 |
Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis.
Topics: Acetylcholine; Adult; Aged; Bipolar Disorder; Brain; Choline; Clinical Trials as Topic; Double-Blind | 1978 |
106 other studies available for choline and Schizophrenia
| Article | Year |
|---|---|
Magnetic resonance spectroscopic evidence of increased choline in the dorsolateral prefrontal and visual cortices in recent onset schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonan | 2022 |
Serum Metabolic Profile in Schizophrenia Patients With Antipsychotic-Induced Constipation and Its relationship With Gut Microbiome.
Topics: Adult; Antipsychotic Agents; Case-Control Studies; Choline; Constipation; Female; Gastrointestinal M | 2023 |
Preliminary Findings Associate Hippocampal
Topics: Adult; Aspartic Acid; Choline; Female; Hippocampus; Humans; Male; Mania; Middle Aged; Proton Magneti | 2021 |
A proof of concept 'phase zero' study of neurodevelopment using brain organoid models with Vis/near-infrared spectroscopy and electrophysiology.
Topics: Acetylcarnitine; Brain; Case-Control Studies; Cell Line; Choline; Electron Transport Complex IV; Ele | 2020 |
Plasma ratio of clozapine to N-desmethylclozapine can predict cognitive performance in treatment-resistant psychotic patients.
Topics: Adult; Aged; Antipsychotic Agents; Choline; Clozapine; Cognition; Cross-Sectional Studies; Dopamine; | 2017 |
Striatal neurometabolite levels in patients with schizophrenia undergoing long-term antipsychotic treatment: A proton magnetic resonance spectroscopy and reliability study.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine | 2018 |
Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis.
Topics: Adolescent; Adult; Choline; Female; Gastrointestinal Microbiome; Gyrus Cinguli; Humans; Magnetic Res | 2018 |
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Diseas | 2018 |
Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy.
Topics: Anhedonia; Animals; Choline; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; | 2019 |
Role of glia in prefrontal white matter abnormalities in first episode psychosis or mania detected by diffusion tensor spectroscopy.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Diffusion Tensor Im | 2019 |
Prevention of schizophrenia: an impossible dream?
Topics: Attention; Brain; Choline; Female; Humans; Male; Neural Inhibition; Nootropic Agents; Phosphorylchol | 2013 |
Proton magnetic resonance spectroscopy (H-MRS) in chronic schizophrenia. A single-voxel study in three regions involved in a pathogenetic theory.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebellum; Choline; Creatine; Female; Humans; Magnetic | 2013 |
Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain; Brain Chemistry; Caudate Nucleus; Choline; Cross- | 2013 |
Increased glutamine in patients undergoing long-term treatment for schizophrenia: a proton magnetic resonance spectroscopy study at 3 T.
Topics: Adult; Choline; Cross-Sectional Studies; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Ma | 2014 |
Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Choline; Diet | 2014 |
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Age of Onset; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Choline; | 2014 |
Study of the inferior colliculus in patients with schizophrenia by magnetic resonance spectroscopy.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Chlorpromazine; Choline; Creatine; Female; Hallucination | 2014 |
The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzazepines; Cell Line, Tumor; Cho | 2014 |
GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glutamic | 2014 |
Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Biomarkers; Blood Chemical Analysis; Blood Platelets; Choline; Do | 2015 |
The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Autistic Disorder; Behavior, Animal; Choline; Dise | 2015 |
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline | 2015 |
Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation.
Topics: Adult; Age Factors; Anisotropy; Aspartic Acid; Case-Control Studies; Choline; Creatine; Diffusion Te | 2015 |
Elevated Myo-Inositol, Choline, and Glutamate Levels in the Associative Striatum of Antipsychotic-Naive Patients With First-Episode Psychosis: A Proton Magnetic Resonance Spectroscopy Study With Implications for Glial Dysfunction.
Topics: Adult; Aspartic Acid; Choline; Corpus Striatum; Glutamic Acid; Glutamine; Humans; Inositol; Neurogli | 2016 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin | 2016 |
Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Hippocampus; Humans; Imaging, Three-Dimensional; Ma | 2016 |
1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients.
Topics: Choline; Chronic Disease; Creatine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectrosc | 2016 |
Glutamatergic and Neuronal Dysfunction in Gray and White Matter: A Spectroscopic Imaging Study in a Large Schizophrenia Sample.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Gray Ma | 2017 |
Automatic relevance determination for identifying thalamic regions implicated in schizophrenia.
Topics: Aspartic Acid; Brain Mapping; Choline; Humans; Image Processing, Computer-Assisted; Linear Models; M | 2008 |
Spectroscopic metabolomic abnormalities in the thalamus related to auditory hallucinations in patients with schizophrenia.
Topics: Adult; Aspartic Acid; Brief Psychiatric Rating Scale; Choline; Creatine; Diagnostic and Statistical | 2008 |
SNAP-25 genotype influences NAA/Cho in left hippocampus.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; DNA; Female; Genotype; Hippocampus; Humans; Magneti | 2008 |
Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS).
Topics: Adult; Analysis of Variance; Aspartic Acid; Basal Ganglia; Choline; Creatine; Female; Glutamic Acid; | 2009 |
Proton magnetic resonance spectroscopy of the frontal, cingulate and perirolandic cortices and its relationship to skin conductance in patients with schizophrenia.
Topics: Acoustic Stimulation; Adult; Aspartic Acid; Case-Control Studies; Cerebral Cortex; Choline; Creatine | 2008 |
Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; Gyrus Cinguli; Humans; M | 2009 |
[Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery].
Topics: Adolescent; Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Hippocampus; Huma | 2009 |
T2 relaxation time abnormalities in bipolar disorder and schizophrenia.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Brain; Choline; Creatine; Female; Humans; Magnet | 2010 |
N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Child; Choline; Cognition Disorders; Cogniti | 2010 |
1 H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Mapping; Chi-Square Distributio | 2011 |
Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain Mapping; Choline; Family; Female; Huma | 2011 |
Multivoxel proton MR spectroscopy used to distinguish anterior cingulate metabolic abnormalities in patients with schizophrenia.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Gyrus Cinguli; Humans; Image | 2011 |
Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first-episode treatment-naïve schizophrenia patients.
Topics: Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Creatine; Dominance, Cerebral; Fema | 2012 |
[Proton magnetic resonance spectroscopy and diffusion tensor imaging study of first-episode patients with positive symptoms of schizophrenia].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Diffusion Tensor Imaging; Female; Gyrus | 2012 |
Postnatal choline levels mediate cognitive deficits in a rat model of schizophrenia.
Topics: Animals; Choline; Choline Deficiency; Cognition Disorders; Disease Models, Animal; Dizocilpine Malea | 2012 |
Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenics.
Topics: Adult; Choline; Chronic Disease; Creatine; Female; Functional Laterality; Humans; Magnetic Resonance | 2002 |
Neural damage in the lenticular nucleus linked with tardive dyskinesia in schizophrenia: a preliminary study using proton magnetic resonance spectroscopy.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine | 2002 |
1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophrenia.
Topics: Adult; Aspartic Acid; Choline; Creatine; Emotions; Female; Gyrus Cinguli; Humans; Magnetic Resonance | 2002 |
Multiregional 1H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia.
Topics: Adult; Aspartic Acid; Basal Ganglia; Case-Control Studies; Choline; Female; Hippocampus; Humans; Mag | 2003 |
On biochemical studies of schizophrenia. I. An enzymological study on brain tissue and serum of schizophrenic patients; choline esterase.
Topics: Blood; Brain; Choline; Esterases; Humans; Neurochemistry; Schizophrenia | 1953 |
[Differences in the cardiovascular response of hebephrenics, catatonics and paranoids to acetyl-beta-methyl-choline (mecholyl)].
Topics: Cardiovascular System; Catatonia; Choline; Methacholine Chloride; Schizophrenia | 1953 |
Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Fema | 2003 |
Drug-induced parkinsonism in relation to choline-containing compounds measured by 1H-MR spectroscopy in putamen of chronically medicated patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Basal Ganglia Diseases; Choline; Chronic Disease; Creati | 2003 |
[Urinary excretion of triethylamine in mental diseases under normal conditions and after choline administration, with special reference to schizophrenia].
Topics: Choline; Ethylamines; Humans; Mental Disorders; Psychotic Disorders; Schizophrenia | 1950 |
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain Mapping; Choline; Creatine; Depressive Dis | 2003 |
1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Mapping; Caudate Nucleus; Child; Choline; Creat | 2004 |
Duration of untreated psychosis vs. N-acetylaspartate and choline in first episode schizophrenia: a 1H magnetic resonance spectroscopy study at 4.0 Tesla.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Cell Death; Choline; Cohort Studies; Dominance, Cerebral; F | 2004 |
N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI.
Topics: Adult; Anterior Thalamic Nuclei; Aspartic Acid; Choline; Creatine; Humans; Magnetic Resonance Imagin | 2005 |
Proton magnetic resonance spectroscopy of the anterior cingulate gyrus, insular cortex and thalamus in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).
Topics: Adult; Aspartic Acid; Cerebral Cortex; Choline; Female; Gilbert Disease; Gyrus Cinguli; Humans; Inos | 2005 |
Quantitative magnetic resonance spectroscopy of schizophrenia: relationship between decreased N-acetylaspartate and frontal lobe dysfunction.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Frontal Lobe; Humans; Image Processing, Computer-As | 2006 |
Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia.
Topics: Adult; Aspartic Acid; Choline; Female; Frontal Lobe; Gyrus Cinguli; Humans; Interview, Psychological | 2006 |
Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Antipsychotic Agents; Aspartic Acid; Choline; Chronic Disease; Cognition Disorders; Cre | 2007 |
Regarding "Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study".
Topics: Aspartic Acid; Choline; Creatine; Dominance, Cerebral; Glutamic Acid; Gyrus Cinguli; Hippocampus; Hu | 2007 |
Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Follow-Up Studies; Functional Laterality; Hippocamp | 2006 |
Brain metabolite abnormalities in the white matter of elderly schizophrenic subjects: implication for glial dysfunction.
Topics: Aged; Alanine; Brain; Brain Mapping; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Ma | 2007 |
Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Cerebrospinal Fluid; Choline; Chronic Disease; Creatine; Fou | 2007 |
The effect of clozapine on neuroimaging findings in schizophrenia.
Topics: Aged, 80 and over; Antipsychotic Agents; Aspartic Acid; Brain; Choline; Clozapine; Creatine; Energy | 2007 |
Magnetic resonance imaging and spectroscopy in a mouse model of schizophrenia.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Disease Models, Animal; Image Interpretation, Comp | 2008 |
A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Female; Frontal Lobe; Functional Late | 2008 |
Tardive dyskinesia: clinical, biological, and pharmacological perspectives.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Choline; Corpus Striatum; Diagnosis, Differential; Dop | 1980 |
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls.
Topics: Adolescent; Adult; Age Factors; Aged; Bipolar Disorder; Calcium; Choline; Depressive Disorder; Femal | 1984 |
Elevation of choline and glycine in red blood cells of psychiatric patients due to lithium treatment.
Topics: Adult; Affective Disorders, Psychotic; Choline; Erythrocytes; Female; Glycine; Humans; Lithium; Male | 1981 |
Serial proton magnetic resonance spectroscopy in a patient with acute carbon monoxide poisoning.
Topics: Adult; Aspartic Acid; Carbon Monoxide Poisoning; Carboxyhemoglobin; Choline; Creatine; Energy Metabo | 1995 |
1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates.
Topics: Adult; Choline; Cognition Disorders; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spec | 1994 |
Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report.
Topics: Adult; Arousal; Aspartic Acid; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Fr | 1995 |
Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia.
Topics: Adult; Aspartic Acid; Basal Ganglia; Basal Ganglia Diseases; Brain Mapping; Choline; Chronic Disease | 1996 |
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali | 1996 |
Proton magnetic resonance spectroscopy of the basal ganglia in patients with schizophrenia: a preliminary report.
Topics: Adolescent; Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Educational Status; Female; Func | 1996 |
Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatinine; Female; Hippocampus; Humans; Magnetic Resonance Sp | 1996 |
Decreased left frontal lobe N-acetylaspartate in schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Biomarkers; Cell Count; Choline; Creatine; Female; Funct | 1997 |
Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls.
Topics: Adult; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Ima | 1996 |
Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; F | 1997 |
Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia.
Topics: Adult; Age of Onset; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Educational Status; H | 1998 |
Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Hippocampus; Humans; M | 1998 |
Regional proton magnetic resonance spectroscopy in schizophrenia and exploration of drug effect.
Topics: Adult; Aged; Analysis of Variance; Antipsychotic Agents; Aspartic Acid; Basal Ganglia; Brain; Case-C | 1998 |
Single-voxel proton magnetic resonance spectroscopy of the pons and cerebellum in patients with schizophrenia: a preliminary study.
Topics: Adult; Cerebellum; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Mal | 1998 |
The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia.
Topics: Adult; Animals; Aspartic Acid; Choline; Chronic Disease; Corpus Striatum; Creatinine; Dopamine; Fema | 1999 |
Heritability heightens brain metabolite differences in schizophrenia.
Topics: Adult; Aspartic Acid; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Genetic Pre | 2000 |
Subtype-associated metabolite differences in the temporal lobe in schizophrenia detected by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Humans; Ino | 1999 |
Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia.
Topics: Adult; Aspartic Acid; Cell Count; Choline; Creatine; Functional Laterality; Humans; Magnetic Resonan | 2000 |
Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Frontal Lobe; Humans; Magneti | 2000 |
Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Female; Frontal Lobe; Humans; Magnetic Resonance Imagi | 2000 |
Proton magnetic resonance spectroscopy (1H-MRS) of the cerebellum in men with schizophrenia.
Topics: Adult; Aspartic Acid; Cerebellum; Choline; Creatine; Humans; Magnetic Resonance Imaging; Magnetic Re | 2000 |
Lower concentration of thalamic n-acetylaspartate in patients with schizophrenia: a replication study.
Topics: Adult; Aspartic Acid; Choline; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Ma | 2001 |
Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation.
Topics: Adult; Aspartic Acid; Atrophy; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Hu | 2001 |
High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophrenia.
Topics: Adult; Aspartic Acid; Caudate Nucleus; Choline; Creatine; Dominance, Cerebral; Female; Humans; Magne | 2002 |
Tardive dyskinesia.
Topics: Antipsychotic Agents; Baclofen; Benzodiazepines; Choline; Dyskinesia, Drug-Induced; Humans; Pimozide | 1979 |
Cerebrospinal fluid acetylcholinesterase in neuropsychiatric disorders.
Topics: Acetylcholinesterase; Adult; Affective Symptoms; Choline; Circadian Rhythm; Humans; Huntington Disea | 1979 |
[Neuroleptic tardive dyskinesias. Completion of the inquiry regarding 1,480 psychiatric hospital patients].
Topics: Age Factors; Aged; Child; Choline; Dyskinesia, Drug-Induced; Female; Hospitals, Psychiatric; Humans; | 1977 |
[Effect of CDP-choline on GH release in patients with chronic psychopathy].
Topics: Adult; Choline; Chronic Disease; Depression; Female; Growth Hormone; Humans; Male; Mental Disorders; | 1978 |
Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Energ | 1992 |
RBC and plasma choline in neuroleptic-treated schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Brain; Choline; Chronic Disease; Erythrocytes; Female; Haloperidol; Hum | 1989 |
RBC-choline: a biological marker of the outcome of lithium prophylaxis?
Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Choline; Erythrocytes; Hu | 1987 |
Regional distribution of some enzymes involved with putative neurotransmitters in the human visual system.
Topics: Acetylcholine; Acetylcholinesterase; Acetyltransferases; Adolescent; Adult; Aged; Autopsy; Brain Che | 1973 |
Various enzymes involved with putative neurotransmitters. Regional distribution in the brain of deceased mentally normal, chronic schizophrenics or organic brain syndrome patients.
Topics: Acetylcholinesterase; Acetyltransferases; Adolescent; Adult; Age Factors; Aged; Brain; Brain Chemist | 1973 |
Proceedings: Post-mortem measurement of enzymes in human brain: evidence of a central noradrenergic deficit in schizophrenia.
Topics: Acetyltransferases; Brain; Catechol O-Methyltransferase; Choline; Dopamine beta-Hydroxylase; Humans; | 1974 |
Serum pseudocholinesterase activity in schizophrenia.
Topics: Acetylcholine; Adolescent; Adult; Aged; Choline; Cholinesterases; Esters; Female; Humans; Liver Func | 1970 |
[On methylation processes in metabolism].
Topics: Biochemical Phenomena; Biochemistry; Choline; Dietary Fats; Epinephrine; Fatty Liver; Humans; Mescal | 1969 |