choline and Psychotic Disorders
choline has been researched along with Psychotic Disorders in 34 studies
Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride." | 9.04 | Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. ( Berger, PA; Davis, KL, 1978) |
| "Maternal choline supplementation and/or a choline-rich diet during pregnancy should be further investigated because of evidence of beneficial effects on infant mental functioning, low cost and few side effects." | 5.41 | [The influence of maternal choline supplementation on fetal brain development and the risk of psychotic symptoms]. ( Eijsink, JJH; Hoenders, HJR; Knegtering, H; Spoelstra, SK, 2023) |
| "The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride." | 5.04 | Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. ( Berger, PA; Davis, KL, 1978) |
| "Huntington's chorea, ataxias, Tourette's syndrome, schizophrenia, affective illness, and senile dementia of the Alzheimer type, has been implicated with a general underactivity of central cholinergic mechanisms." | 2.36 | The use of cholinergic precursors in neuropsychiatric diseases. ( Davis, KL; Rosenberg, GS, 1982) |
| "Choline was significantly elevated in FEP compared to HC." | 1.48 | Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients. ( Gonzales, SS; Kraguljac, NV; Lahti, AC; Morgan, CJ; Sivaraman, S; White, DM, 2018) |
| "Schizophrenia is associated with significant brain abnormalities, including changes in brain metabolites as measured by proton magnetic resonance spectroscopy (MRS)." | 1.35 | A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis. ( Berger, GE; McConchie, M; McGorry, PD; Pantelis, C; Proffitt, T; Velakoulis, D; Wellard, RM; Wood, SJ, 2008) |
| "A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy." | 1.33 | Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis. ( Erfurth, A; Lüdemann, P; Michael, N; Möller, HE; Schuierer, G, 2005) |
| "Following the chronic use of methamphetamine, some individuals experience psychosis and anxiety." | 1.31 | Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study. ( Ashby, CR; Isoda, H; Iyo, M; Kawai, M; Minabe, Y; Mori, N; Sakahara, H; Sekine, Y; Suzuki, K; Takei, N, 2002) |
| "Cholinergic processes were measured in plasma and red blood cells (RBC) obtained from patients with mania, depression, and schizophrenia." | 1.27 | Cholinergic processes in blood samples from patients with major psychiatric disorders. ( Alarcon, RD; Jope, RS; Lally, KM; Walter-Ryan, WG, 1985) |
Research
Studies (34)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.59) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 12 (35.29) | 24.3611 |
| 2020's | 6 (17.65) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chen, X | 4 |
| Fan, X | 2 |
| Song, X | 1 |
| Gardner, M | 1 |
| Du, F | 3 |
| Öngür, D | 3 |
| Spoelstra, SK | 1 |
| Eijsink, JJH | 1 |
| Hoenders, HJR | 1 |
| Knegtering, H | 1 |
| Whitehurst, TS | 1 |
| Osugo, M | 1 |
| Townsend, L | 1 |
| Shatalina, E | 1 |
| Vava, R | 1 |
| Onwordi, EC | 1 |
| Howes, O | 1 |
| Malaspina, D | 1 |
| Lotan, E | 1 |
| Rusinek, H | 1 |
| Perez, SA | 1 |
| Walsh-Messinger, J | 1 |
| Kranz, TM | 1 |
| Gonen, O | 1 |
| Freedman, R | 1 |
| Hunter, SK | 1 |
| Law, AJ | 1 |
| Clark, AM | 1 |
| Roberts, A | 1 |
| Hoffman, MC | 1 |
| Kuan, E | 1 |
| Molins, C | 1 |
| Carceller-Sindreu, M | 1 |
| Navarro, H | 1 |
| Carmona, C | 1 |
| Piñeiro, M | 1 |
| Martínez, E | 1 |
| Álvarez, E | 1 |
| Portella, MJ | 1 |
| He, Y | 1 |
| Kosciolek, T | 1 |
| Tang, J | 1 |
| Zhou, Y | 1 |
| Li, Z | 1 |
| Ma, X | 1 |
| Zhu, Q | 1 |
| Yuan, N | 1 |
| Yuan, L | 1 |
| Li, C | 1 |
| Jin, K | 1 |
| Knight, R | 1 |
| Tsuang, MT | 1 |
| Sivaraman, S | 1 |
| Kraguljac, NV | 1 |
| White, DM | 1 |
| Morgan, CJ | 1 |
| Gonzales, SS | 1 |
| Lahti, AC | 1 |
| Bahous, RH | 1 |
| Cosín-Tomás, M | 1 |
| Deng, L | 2 |
| Leclerc, D | 2 |
| Malysheva, O | 2 |
| Ho, MK | 1 |
| Pallàs, M | 1 |
| Kaliman, P | 1 |
| Bedell, BJ | 2 |
| Caudill, MA | 2 |
| Rozen, R | 3 |
| Lewandowski, KE | 1 |
| Huynh, P | 1 |
| Vingerhoets, C | 1 |
| Bakker, G | 1 |
| Schrantee, A | 1 |
| van der Pluijm, M | 1 |
| Bloemen, OJN | 1 |
| Reneman, L | 1 |
| Caan, M | 1 |
| Booij, J | 1 |
| van Amelsvoort, TAMJ | 1 |
| Howells, FM | 1 |
| Uhlmann, A | 1 |
| Temmingh, H | 1 |
| Sinclair, H | 1 |
| Meintjes, E | 1 |
| Wilson, D | 1 |
| Stein, DJ | 1 |
| Shendyapina, MV | 1 |
| Omelchenko, MA | 1 |
| Lebedeva, IS | 1 |
| Kanonovich, PS | 1 |
| Semenova, NA | 1 |
| Ublinsky, MV | 1 |
| Dmitrienko, DM | 1 |
| Akhadov, TA | 1 |
| Simonova, OA | 1 |
| Kaleda, VG | 1 |
| Plitman, E | 1 |
| de la Fuente-Sandoval, C | 1 |
| Reyes-Madrigal, F | 1 |
| Chavez, S | 1 |
| Gómez-Cruz, G | 1 |
| León-Ortiz, P | 1 |
| Graff-Guerrero, A | 1 |
| Brandt, AS | 1 |
| Unschuld, PG | 1 |
| Pradhan, S | 1 |
| Lim, IA | 1 |
| Churchill, G | 1 |
| Harris, AD | 1 |
| Hua, J | 1 |
| Barker, PB | 1 |
| Ross, CA | 1 |
| van Zijl, PC | 1 |
| Edden, RA | 1 |
| Margolis, RL | 1 |
| Jadavji, NM | 1 |
| Mikael, LG | 1 |
| Pancer, J | 1 |
| Jiang, X | 1 |
| Wu, Q | 1 |
| Caudill, M | 1 |
| Sekine, Y | 1 |
| Minabe, Y | 1 |
| Kawai, M | 1 |
| Suzuki, K | 1 |
| Iyo, M | 1 |
| Isoda, H | 1 |
| Sakahara, H | 1 |
| Ashby, CR | 1 |
| Takei, N | 1 |
| Mori, N | 1 |
| POLONI, A | 1 |
| Wood, SJ | 3 |
| Berger, G | 1 |
| Velakoulis, D | 3 |
| Phillips, LJ | 1 |
| McGorry, PD | 3 |
| Yung, AR | 1 |
| Desmond, P | 2 |
| Pantelis, C | 3 |
| Michael, N | 1 |
| Erfurth, A | 1 |
| Lüdemann, P | 1 |
| Schuierer, G | 1 |
| Möller, HE | 1 |
| Berger, GE | 2 |
| Lambert, M | 1 |
| Conus, P | 1 |
| Stuart, GW | 1 |
| Zabala, A | 1 |
| Sánchez-González, J | 1 |
| Parellada, M | 1 |
| Moreno, DM | 1 |
| Reig, S | 1 |
| Burdalo, MT | 1 |
| Robles, O | 1 |
| Desco, M | 1 |
| Arango, C | 1 |
| Bennouna, M | 1 |
| Greene, VB | 1 |
| Defranoux, L | 1 |
| Wellard, RM | 1 |
| Proffitt, T | 1 |
| McConchie, M | 1 |
| Haag, M | 1 |
| Haag, H | 1 |
| Eisenried, F | 1 |
| Greil, W | 1 |
| Rosenberg, GS | 1 |
| Davis, KL | 2 |
| Deutsch, SI | 1 |
| Stanley, M | 1 |
| Peselow, ED | 1 |
| Banay-Schwartz, M | 1 |
| Renshaw, PF | 1 |
| Yurgelun-Todd, DA | 1 |
| Tohen, M | 1 |
| Gruber, S | 1 |
| Cohen, BM | 2 |
| Berger, PA | 1 |
| Stoll, AL | 1 |
| Hanin, I | 1 |
| Jope, RS | 1 |
| Walter-Ryan, WG | 1 |
| Alarcon, RD | 1 |
| Lally, KM | 1 |
| Koh, CV | 1 |
| Ananth, JV | 1 |
| Ban, TA | 1 |
| Lehmann, HE | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study on Predictiors and Mechanism of Conversion to Psychosis in Individuals at Ultra-high Risk Group[NCT03965598] | 200 participants (Anticipated) | Observational | 2016-11-01 | Recruiting | |||
| Glutamate, Brain Connectivity and Duration of Untreated Psychosis[NCT02034253] | 134 participants (Actual) | Observational | 2014-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
6 reviews available for choline and Psychotic Disorders
| Article | Year |
|---|---|
[The influence of maternal choline supplementation on fetal brain development and the risk of psychotic symptoms].
Topics: Animals; Brain; Choline; Dietary Supplements; Family; Female; Humans; Pregnancy; Psychotic Disorders | 2023 |
Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis.
Topics: Aspartic Acid; Choline; Humans; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizop | 2020 |
Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum.
Topics: Brain; Child; Choline; Dietary Supplements; Female; Fetal Development; Folic Acid; Humans; Micronutr | 2022 |
[Cholinergic hypothesis in psychosis following traumatic brain injury and cholinergic hypothesis in schizophrenia: a link?].
Topics: Brain Injuries; Choline; Humans; Psychotic Disorders; Schizophrenia | 2007 |
The use of cholinergic precursors in neuropsychiatric diseases.
Topics: Acetylcholine; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Cerebellar Ataxia; Choline; Huma | 1982 |
Glycine: a possible role in lithium's action and affective illness.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Autistic Disorder; Bipolar Disorder; Brain Chemistry; | 1983 |
Trials
3 trials available for choline and Psychotic Disorders
| Article | Year |
|---|---|
Influence of muscarinic M
Topics: Adult; Biperiden; Brain; Choline; Cognition; Corpus Striatum; Cross-Over Studies; Female; Gyrus Cing | 2019 |
Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis.
Topics: Acetylcholine; Adult; Aged; Bipolar Disorder; Brain; Choline; Clinical Trials as Topic; Double-Blind | 1978 |
Troxonium tosylate in the treatment of drug-induced extrapyramidal manifestations.
Topics: Adult; Benzoates; Choline; Clinical Trials as Topic; Esters; Ethanol; Extrapyramidal Tracts; Female; | 1971 |
Other Studies
25 other studies available for choline and Psychotic Disorders
| Article | Year |
|---|---|
White Matter Metabolite Relaxation and Diffusion Abnormalities in First-Episode Psychosis: A Longitudinal Study.
Topics: Aspartic Acid; Brain; Choline; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Human | 2022 |
Preliminary Findings Associate Hippocampal
Topics: Adult; Aspartic Acid; Choline; Female; Hippocampus; Humans; Male; Mania; Middle Aged; Proton Magneti | 2021 |
N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects.
Topics: Aspartic Acid; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Neurons; Psychotic Disord | 2021 |
Plasma ratio of clozapine to N-desmethylclozapine can predict cognitive performance in treatment-resistant psychotic patients.
Topics: Adult; Aged; Antipsychotic Agents; Choline; Clozapine; Cognition; Cross-Sectional Studies; Dopamine; | 2017 |
Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis.
Topics: Adolescent; Adult; Choline; Female; Gastrointestinal Microbiome; Gyrus Cinguli; Humans; Magnetic Res | 2018 |
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Diseas | 2018 |
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Topics: Aging; Amyloid beta-Peptides; Animals; Anxiety; Brain; Cell Survival; Cerebral Cortex; Choline; CpG | 2019 |
Role of glia in prefrontal white matter abnormalities in first episode psychosis or mania detected by diffusion tensor spectroscopy.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Diffusion Tensor Im | 2019 |
(1)H-magnetic resonance spectroscopy ((1)H-MRS) in methamphetamine dependence and methamphetamine induced psychosis.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamine; Humans; Inositol; Mag | 2014 |
[Information processing and brain metabolic characteristics in patients at ultra-high risk for endogenous psychosis].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Evoked Potentials; Female; Glutamic Acid; Glutamin | 2015 |
Elevated Myo-Inositol, Choline, and Glutamate Levels in the Associative Striatum of Antipsychotic-Naive Patients With First-Episode Psychosis: A Proton Magnetic Resonance Spectroscopy Study With Implications for Glial Dysfunction.
Topics: Adult; Aspartic Acid; Choline; Corpus Striatum; Glutamic Acid; Glutamine; Humans; Inositol; Neurogli | 2016 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin | 2016 |
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
Topics: Animals; Apoptosis; Behavior, Animal; Brain; Cerebellum; Choline; Choline O-Acetyltransferase; DNA M | 2012 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo | 2013 |
Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Basal Ganglia; Central Nervous System Stimulants; Cholin | 2002 |
[Urinary excretion of triethylamine in mental diseases under normal conditions and after choline administration, with special reference to schizophrenia].
Topics: Choline; Ethylamines; Humans; Mental Disorders; Psychotic Disorders; Schizophrenia | 1950 |
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain Mapping; Choline; Creatine; Depressive Dis | 2003 |
Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis.
Topics: Adult; Aspartic Acid; Choline; Electroconvulsive Therapy; Humans; Immunologic Factors; Inositol; Int | 2005 |
Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Follow-Up Studies; Functional Laterality; Hippocamp | 2006 |
Findings of proton magnetic resonance spectometry in the dorsolateral prefrontal cortex in adolescents with first episodes of psychosis.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Cross-Sectional Studies; Female; Follow-Up Stud | 2007 |
A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Female; Frontal Lobe; Functional Late | 2008 |
RBC-choline: changes by lithium and relation to prophylactic response.
Topics: Age Factors; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Choline; Depressive Diso | 1984 |
Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis.
Topics: Adult; Aspartic Acid; Choline; Creatinine; Female; Functional Laterality; Humans; Magnetic Resonance | 1995 |
Erythrocyte choline concentrations in psychiatric disorders.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Bipolar Disorder; Choline; Dementia; Depressi | 1991 |
Cholinergic processes in blood samples from patients with major psychiatric disorders.
Topics: Acetylcholinesterase; Bipolar Disorder; Choline; Cholinesterases; Depressive Disorder; Erythrocytes; | 1985 |