choline has been researched along with Pregnancy in 665 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In pregnancy, choline is deemed an essential nutrient and carnitine needs are increased, but amounts remain undefined." | 9.69 | Dynamic Metabolic Signatures of Choline and Carnitine across Healthy Pregnancy and in Cord Blood: Association with Maternal Dietary Protein. ( Atkinson, SA; Bogert, M; Britz-McKibbin, P; Kroezen, Z; Shanmuganathan, M, 2023) |
| "Pregnancy places a unique stress upon choline metabolism, requiring adaptations to support both maternal and fetal requirements." | 9.41 | Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial. ( Bender, E; Caudill, MA; Devapatla, S; Klatt, KC; Malysheva, OV; McDougall, MQ; Nevins, JEH; Taesuwan, S; Vidavalur, R, 2021) |
| "A limited number of studies suggest that maternal choline supplementation during pregnancy may enhance fetal brain development and improve early signs and symptoms that may predispose to mental illness." | 9.41 | Maternal choline supplementation during pregnancy to promote mental health in offspring. ( Eijsink, JJH; Hoenders, HJR; Knegtering, H; Spoelstra, SK, 2023) |
| "Despite participation in overlapping metabolic pathways, the relationship between choline and vitamin B-12 has not been well characterized especially during pregnancy." | 9.30 | Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy. ( Bae, S; Caudill, MA; Jiang, X; King, JH; Klatt, KC; Kwan, STC; Malysheva, OV; Roberson, MS; Yan, J, 2019) |
| "Rodent studies demonstrate that supplementing the maternal diet with choline during pregnancy produces life-long cognitive benefits for the offspring." | 9.27 | Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. ( Canfield, RL; Caudill, MA; Muscalu, L; Nevins, JEH; Strupp, BJ, 2018) |
| "We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy." | 9.27 | Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Herbert, JS; Hoyme, HE; Jacobson, JL; Jacobson, SW; Lewis, CE; Lindinger, NM; Meintjes, EM; Molteno, CD; Stanton, ME; Zeisel, SH, 2018) |
| "Overall, these data demonstrate significant alterations in markers of biotin metabolism during pregnancy and lactation and suggest that biotin intakes exceeding current recommendations are needed to meet the demands of these reproductive states." | 9.19 | Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. ( Caudill, MA; Gayle, A; Jiang, X; Lucas, LK; Malysheva, O; Perry, CA; West, AA; Yan, J, 2014) |
| "Although biomarkers of choline metabolism are altered by pregnancy, little is known about the influence of human pregnancy on the dynamics of choline-related metabolic processes." | 9.17 | Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. ( Allen, RH; Brenna, JT; Caudill, MA; Gregory, JF; Jiang, X; Malysheva, OV; Perry, CA; Stabler, SP; West, AA; Yan, J, 2013) |
| "Two experiments were conducted to evaluate if supplementing rumen-protected choline (RPC; Reashure, Balchem Encapsulates, Slate Hill, NY) could prevent or alleviate fatty liver in dairy cattle." | 9.12 | Supplemental choline for prevention and alleviation of fatty liver in dairy cattle. ( Bertics, SJ; Caraviello, DZ; Cooke, RF; Grummer, RR; Ramos, MH; Silva Del Río, N, 2007) |
| "Adequate choline intake during pregnancy is essential for proper fetal development." | 8.91 | [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. ( Drews, K, 2015) |
| "Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment." | 8.31 | Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring. ( Hurley, L; Ille, S; Jadavji, NM; Jauhal, J; Malysheva, OV; Pull, K, 2023) |
| "The mean daily dietary choline during pregnancy was 372 (standard deviation (SD) 104) mg/day." | 8.31 | The distribution of dietary choline intake and serum choline levels in Australian women during pregnancy and associated early life factors. ( Burgner, D; Collier, F; Dawson, SL; Dewey, D; Field, CJ; Mansell, T; Marx, W; Novakovic, B; O'Hely, M; Ponsonby, AL; Saffery, R; Staskova, L; Vuillermin, P, 2023) |
| "Objectives were to determine the effects of supplementing increasing amounts of choline ion on hepatic composition and mRNA abundance in pregnant dry cows subjected to a fatty liver induction protocol." | 8.31 | Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows. ( Arshad, U; Santos, JEP; Staples, CR; Tribulo, P; Zenobi, MG, 2023) |
| "Our objectives were to examine whether fetal vulnerability to PAE-related growth restriction is modified by: 1) rate of gestational weight gain; or prenatal dietary intakes of 2) energy, 3) iron, or 4) choline." | 8.12 | Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Senekal, M, 2022) |
| "This study investigated the interaction of choline and FA in gestational diets on food intake, body weight, one-carbon metabolism, and hypothalamic gene expression in male Wistar rat offspring." | 8.02 | Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring. ( Anderson, GH; Bottiglieri, T; Caudill, MA; Hammoud, R; Kubant, R; Malysheva, OV; Pannia, E; Wasek, B, 2021) |
| "Sufficient choline and betaine during pregnancy are needed for fetal growth and development." | 8.02 | Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study. ( Eussen, SJ; Moltó-Puigmartí, C; Mommers, M; Obeid, R; Thijs, C, 2021) |
| "The objective of this study was to explore the metabolic profiles of pregnancy malnutrition induced by feed restriction (FR) and the counteracting effects of glycerol and rumen-protected choline chloride supplementation." | 7.96 | Urine metabolome alterations in malnutrition and the impact of glycerol or rumen-protected choline chloride supplementation in advanced pregnant ewes. ( Guo, C; Hu, F; Mao, S; Xuan, H; Xue, Y; Yin, Y, 2020) |
| "Compared with the lowest quartile of choline intake, women within the highest consumption quartile had adjusted odds ratio (aOR) for preterm birth of 0." | 7.96 | Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study. ( Cai, W; He, XL; Kohlmeier, M; Liu, YH; Shen, LW; Tang, QY; Wang, B; Yi, XX; Zhou, LL; Zhu, J, 2020) |
| "Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD)." | 7.91 | Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ginsberg, SD; Kelley, CM; Mufson, EJ; Strupp, BJ, 2019) |
| "Lipopolysaccharide significantly increased SBP and urinary albumin and decreased pregnancy outcomes, and these effects were partially reversed by higher choline treatment." | 7.88 | Choline Supplementation During Pregnancy Protects Against Gestational Lipopolysaccharide-Induced Inflammatory Responses. ( Bao, J; Garfield, RE; Han, X; Liu, H; Shi, SQ; Yang, J; Zhang, M, 2018) |
| "This study suggests that higher maternal plasma choline status during pregnancy is associated with more symptoms of antenatal depression and anxiety, whereas plasma betaine concentrations showed no associations." | 7.85 | Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort. ( Chen, H; Chong, MF; Chong, YS; Godfrey, KM; Meaney, MJ; Quah, PL; Saw, SM; van Lee, L; Yap, FKP, 2017) |
| "The Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD) exhibits cognitive impairment and degeneration of basal forebrain cholinergic neurons (BFCNs)." | 7.85 | Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, MS; Strupp, BJ; Velazquez, R, 2017) |
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 7.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration." | 7.83 | Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016) |
| " A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation." | 7.83 | Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. ( Alldred, MJ; Ash, JA; Caudill, MA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, M; Strupp, BJ; Velazquez, R, 2016) |
| " We used questionnaires to ascertain pre-pregnancy supplementation and estimate usual maternal dietary intake of folate, choline, and folic acid." | 7.83 | A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group. ( Basta, PV; Carrier, KS; Diskin, SJ; Engel, SM; Maris, JM; Maxen, C; Mazul, AL; Naranjo, A; Olshan, AF; Siega-Riz, AM; Vaksman, Z; Weinberg, CR; Zou, F, 2016) |
| "We examined whether perinatal maternal dietary choline deficiency influences porcine-milk composition." | 7.83 | Perinatal Dietary Choline Deficiency in Sows Influences Concentrations of Choline Metabolites, Fatty Acids, and Amino Acids in Milk throughout Lactation. ( Alexander, LS; Caudill, MA; Dilger, RN; Getty, CM; Johnson, SK; Malysheva, OV; Mudd, AT, 2016) |
| "Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs)." | 7.80 | Dietary intake of choline and neural tube defects in Mexican Americans. ( Brender, JD; Canfield, MA; Felkner, M; Lavery, AM; Suarez, L; Sweeney, A; Zhao, H, 2014) |
| " Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years." | 7.79 | Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013) |
| "The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy." | 7.79 | Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. ( Ballesteros, M; Berrocal-Zaragoza, MI; Cavallé-Busquets, P; Fernandez-Ballart, JD; Fernàndez-Roig, S; Murphy, MM; Salat-Batlle, J; Ueland, PM, 2013) |
| "Choline needs are increased in pregnancy." | 7.79 | Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013) |
| ") of saline (control) or kainic acid to induce seizures and were euthanized 16 days later." | 7.77 | Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. ( Blusztajn, JK; Glenn, MJ; Mellott, TJ; Tognoni, CM; Williams, CL; Wong-Goodrich, SJ, 2011) |
| "Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers." | 7.74 | Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. ( Berger-Sweeney, JE; Nag, N, 2007) |
| "Supplementation of maternal diet with the essential nutrient, choline, during the second half of pregnancy in rats causes long-lasting improvements in spatial memory in the offspring and protects them from the memory decline characteristic of old age." | 7.74 | Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. ( Blusztajn, JK; Kowall, NW; Lopez-Coviella, I; Mellott, TJ, 2007) |
| "Prenatal choline supplementation (SUP) protects adult rats against spatial memory deficits observed after excitotoxin-induced status epilepticus (SE)." | 7.74 | Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. ( Blusztajn, JK; Glenn, MJ; Mellott, TJ; Williams, CL; Wong-Goodrich, SJ, 2008) |
| "We investigated the courses of plasma choline and betaine during normal human pregnancy and their relations to plasma tHcy." | 7.73 | Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy. ( Fokkema, MR; Holm, PI; Muskiet, FA; Ueland, PM; van der Dijs, FP; Velzing-Aarts, FV, 2005) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 7.72 | Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003) |
| "The aims of this study were to determine whether serum free choline and phospholipid-bound choline concentrations change during the pregnancy or after childbirth and to determine if the serum choline concentrations of the mother and newborn are correlated." | 7.71 | Free and phospholipid-bound choline concentrations in serum during pregnancy, after delivery and in newborns. ( Ozarda Ilcol, Y; Ulus, IH; Uncu, G, 2002) |
| "Treatment of rats with choline during brain development results in long-lasting enhancement of spatial memory whereas choline deficiency has the opposite effect." | 7.71 | Choline deficiency induces apoptosis in primary cultures of fetal neurons. ( Fernandes, A; Mar, MH; Meeker, RB; Yen, CL; Zeisel, SH, 2001) |
| "Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J." | 7.71 | Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Yang, Y, 2002) |
| "Pregnancy is associated with increased phosphatidylcholine (PC) 16:0/22:6 and PC16:0/20:4 concentrations in rat liver and plasma, guinea-pig liver, and in plasma in women." | 7.70 | Pregnancy-associated adaptations to hepatic phosphatidylcholine biosynthesis in the guinea-pig. ( Burdge, GC; Postle, AD, 1998) |
| "Late pregnancy in the rat (gestational ages 16-21 days) was accompanied by a specific increase in hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) molecular species containing C16:0 at the sn-1 position and polyunsaturated essential fatty acids (PUFA), in particular C22:6(n-3), at the sn-2 position." | 7.69 | Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy. ( Burdge, GC; Hunt, AN; Postle, AD, 1994) |
| " Experimental evidence obtained in rats suggest that the precipitous fall in maternal liver choline concentration nearing the end of pregnancy could lead to a severe reduction in the lipotropic activity of the liver." | 7.66 | Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency? ( Gwee, MC, 1982) |
| "Lithium treatment can affect the transport of choline and lithium ions across cell membranes, but little is known about these effects during pregnancy." | 7.66 | Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport. ( Erstling, C; Hanin, I; Kopp, U; Mallinger, AG; Mallinger, J; Stumpf, RL, 1983) |
| "Choline is a semi-essential nutrient involved in lipid and one-carbon metabolism that is compromised during MAFLD progression." | 5.91 | Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes. ( Bretter, R; Caviglia, JM; Jiang, X; Johnson, CH; Kadam, I; Korsmo, HW; Reaz, A; Saxena, A, 2023) |
| "Choline is a key nutrient in fetal brain development." | 5.62 | Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. ( Balser, M; D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Walker, VK, 2021) |
| "(1) Background: Despite the postulated importance of choline during pregnancy, little is known about the choline intake of Australians during pregnancy." | 5.51 | Estimated Choline Intakes and Dietary Sources of Choline in Pregnant Australian Women. ( Best, KP; Gould, JF; Green, TJ; Makrides, M; Netting, MJ; Probst, Y; Sulistyoningrum, DC; Wood, S, 2022) |
| "MCS during murine pregnancy has fetal sex-specific effects on placental inflammation and angiogenesis, with possible consequences on placental vascular development." | 5.46 | Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner. ( Caudill, MA; Fomin, VG; Jiang, X; King, JH; Kwan, STC; Roberson, MS; Wei, E; Yan, J, 2017) |
| "Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences." | 5.46 | Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. ( Blusztajn, JK; Huleatt, OM; Liu, YB; Mellott, TJ; Pender, SM; Shade, BN; Slack, BE, 2017) |
| "Choline is a fundamental nutrient for brain development and high choline intake during prenatal and/or early postnatal periods is neuroprotective." | 5.42 | High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism. ( Blusztajn, JK; Krykbaeva, M; Langley, EA; Mellott, TJ, 2015) |
| "Choline is a precursor to phosphatidylcholine (PC), a structural molecule in cellular membranes that is crucial for cell growth and function." | 5.42 | Choline deficiency impairs intestinal lipid metabolism in the lactating rat. ( Curtis, JM; da Silva, RP; Field, CJ; Goruk, S; Jacobs, RL; Kelly, KB; Leonard, KA; Lewis, ED; Proctor, SD; Vine, DF, 2015) |
| " Maternal nutritional status may be an important factor in determining the extent to which PAE impacts pregnancy outcomes, particularly the dietary micronutrients folate and choline because they provide methyl groups for DNA methylation via one carbon metabolism." | 5.41 | The role of maternal choline, folate and one-carbon metabolism in mediating the impact of prenatal alcohol exposure on placental and fetal development. ( Cuffe, JSM; Moritz, KM; Steane, SE, 2023) |
| "Maternal choline supplementation and/or a choline-rich diet during pregnancy should be further investigated because of evidence of beneficial effects on infant mental functioning, low cost and few side effects." | 5.41 | [The influence of maternal choline supplementation on fetal brain development and the risk of psychotic symptoms]. ( Eijsink, JJH; Hoenders, HJR; Knegtering, H; Spoelstra, SK, 2023) |
| "Fifty-two infants born to heavy-drinking women who had participated in a choline supplementation trial during pregnancy underwent structural magnetic resonance imaging with a multi-echo FLASH protocol on a 3T Siemens Allegra MRI (median age = 2." | 5.41 | Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes. ( Carter, RC; Dodge, NC; Jacobson, JL; Jacobson, SW; Lindinger, NM; Meintjes, EM; Molteno, CD; van der Kouwe, AJW; Warton, CMR; Warton, FL; Wintermark, P; Zöllei, L, 2021) |
| "Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development." | 5.39 | Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. ( Blom, HJ; den Heijer, M; Hogeveen, M; Semmekrot, BA; Sporken, JM; Ueland, PM, 2013) |
| "Choline is a selective agonist for the alpha7 nicotinic receptor which appears in development before acetylcholine is present." | 5.35 | Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. ( Adams, CE; Kisley, MA; Mellott, TJ; Robbins, E; Stevens, KE, 2008) |
| "Despite participation in overlapping metabolic pathways, the relationship between choline and vitamin B-12 has not been well characterized especially during pregnancy." | 5.30 | Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy. ( Bae, S; Caudill, MA; Jiang, X; King, JH; Klatt, KC; Kwan, STC; Malysheva, OV; Roberson, MS; Yan, J, 2019) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 5.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| "Seventy heavy drinkers, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of 2 g of choline or a placebo from time of enrollment until delivery." | 5.27 | Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Lindinger, NM; Meintjes, EM; Molteno, CD; Senekal, MS; Zeisel, SH, 2018) |
| "We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy." | 5.27 | Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Herbert, JS; Hoyme, HE; Jacobson, JL; Jacobson, SW; Lewis, CE; Lindinger, NM; Meintjes, EM; Molteno, CD; Stanton, ME; Zeisel, SH, 2018) |
| " The World Health Organisation recommends folic acid (FA) supplementation pre-conception and in early pregnancy to reduce the risk of fetal neural tube defects (NTDs)." | 5.22 | High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus. ( Arthurs, AL; Jankovic-Karasoulos, T; Roberts, CT; Smith, MD; Williamson, JM, 2022) |
| "Overall, these data demonstrate significant alterations in markers of biotin metabolism during pregnancy and lactation and suggest that biotin intakes exceeding current recommendations are needed to meet the demands of these reproductive states." | 5.19 | Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. ( Caudill, MA; Gayle, A; Jiang, X; Lucas, LK; Malysheva, O; Perry, CA; West, AA; Yan, J, 2014) |
| "Although biomarkers of choline metabolism are altered by pregnancy, little is known about the influence of human pregnancy on the dynamics of choline-related metabolic processes." | 5.17 | Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. ( Allen, RH; Brenna, JT; Caudill, MA; Gregory, JF; Jiang, X; Malysheva, OV; Perry, CA; Stabler, SP; West, AA; Yan, J, 2013) |
| "We sought to quantify the effects of pregnancy and maternal choline intake on maternal and fetal indicators of choline metabolism." | 5.16 | Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. ( Allen, RH; Caudill, MA; Devapatla, S; Jiang, X; Malysheva, OV; Perry, CA; Pressman, E; Stabler, SP; Vermeylen, F; West, AA; Yan, J, 2012) |
| "As part of a controlled feeding study, we assessed the influence of pregnancy and choline intake on maternal genomic markers." | 5.16 | Pregnancy induces transcriptional activation of the peripheral innate immune system and increases oxidative DNA damage among healthy third trimester pregnant women. ( Bar, HY; Caudill, MA; Devapatla, S; Jiang, X; Malysheva, OV; Perry, CA; Pressman, E; Vermeylen, FM; Wells, MT; West, AA; Yan, J, 2012) |
| "Choline, folic acid, Vitamin D, and n-3 polyunsaturated fatty acids are among the nutrients that have been studied as possible mitigating factors for effects of maternal infection and inflammation on fetal development." | 5.12 | Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development. ( Clark, AM; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ, 2021) |
| "Two experiments were conducted to evaluate if supplementing rumen-protected choline (RPC; Reashure, Balchem Encapsulates, Slate Hill, NY) could prevent or alleviate fatty liver in dairy cattle." | 5.12 | Supplemental choline for prevention and alleviation of fatty liver in dairy cattle. ( Bertics, SJ; Caraviello, DZ; Cooke, RF; Grummer, RR; Ramos, MH; Silva Del Río, N, 2007) |
| "Choline deficiency may contribute to the impaired lean body mass growth and pulmonary and neurocognitive development of preterm infants despite adequate macronutrient supply and weight gain." | 5.01 | Choline and choline-related nutrients in regular and preterm infant growth. ( Bernhard, W; Franz, AR; Poets, CF, 2019) |
| "Adequate choline intake during pregnancy is essential for proper fetal development." | 4.91 | [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. ( Drews, K, 2015) |
| " Folates are important for normal neural tube closure in early gestation, and the efficacy of diet fortification with folic acid in reducing the incidence of neural tube defects is a major success story for public health nutrition." | 4.85 | Importance of methyl donors during reproduction. ( Zeisel, SH, 2009) |
| "Pregnancy and lactation are periods when maternal reserves of choline are depleted." | 4.79 | Choline: essential for brain development and function. ( Zeisel, SH, 1997) |
| "Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment." | 4.31 | Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring. ( Hurley, L; Ille, S; Jadavji, NM; Jauhal, J; Malysheva, OV; Pull, K, 2023) |
| "Objectives were to determine the effects of supplementing increasing amounts of choline ion on hepatic composition and mRNA abundance in pregnant dry cows subjected to a fatty liver induction protocol." | 4.31 | Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows. ( Arshad, U; Santos, JEP; Staples, CR; Tribulo, P; Zenobi, MG, 2023) |
| "Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; 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Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022) |
| "Our objectives were to examine whether fetal vulnerability to PAE-related growth restriction is modified by: 1) rate of gestational weight gain; or prenatal dietary intakes of 2) energy, 3) iron, or 4) choline." | 4.12 | Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Senekal, M, 2022) |
| "Choline is an essential nutrient that is involved in various developmental processes during pregnancy." | 4.12 | Inadequate Choline Intake in Pregnant Women in Germany. ( Kordowski, A; Roeren, M; Sina, C; Smollich, M, 2022) |
| "The importance of adequate choline intake during pregnancy has been well documented, but low intake is common." | 4.02 | Choline intake and associations with egg and dairy consumption among pregnant women attending a high-risk antenatal clinic in South Africa: the NuEMI study. ( Jordaan, EM; Joubert, G; Ngounda, J; Robb, L; Walsh, CM, 2021) |
| "Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid accounts for many of these effects in male, but not in female, offspring." | 4.02 | Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring. ( Aardema, NDJ; Bunnell, ML; Cho, CE; Hintze, KJ; Mjaaseth, UN; Norris, JC; Ward, RE, 2021) |
| "Maternal infection, depression, obesity, and other factors associated with inflammation were assessed at 16 weeks gestation, along with maternal C-reactive protein (CRP), cytokines, and serum choline." | 4.02 | Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. ( D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Wyrwa, A, 2021) |
| "Plasma choline concentration was assayed longitudinally in the 1st and 3rd trimesters and at term-pregnancy in mothers and cord blood." | 4.02 | Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism. ( Fukuoka, H; Funahashi, N; Kato, N; Minoura, S; Nakanishi, M; Nammo, T; Oishi, H; Sato, Y; Tanaka, M; Yano, T; Yasuda, K; Yoshihara, H, 2021) |
| "This study investigated the interaction of choline and FA in gestational diets on food intake, body weight, one-carbon metabolism, and hypothalamic gene expression in male Wistar rat offspring." | 4.02 | Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring. ( Anderson, GH; Bottiglieri, T; Caudill, MA; Hammoud, R; Kubant, R; Malysheva, OV; Pannia, E; Wasek, B, 2021) |
| "Our results suggest that choline has the potential to ameliorate fetal growth restriction associated with PCE and improve placental efficiency following prenatal alcohol exposure." | 4.02 | Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta. ( Akison, LK; Andersen, I; Browne, DJ; Fielding, AM; Gårdebjer, EM; Kalisch-Smith, JI; Kent, NL; Moritz, KM; Steane, SE; Sullivan, MA; Tejo, EN, 2021) |
| "The objective of this study was to explore the metabolic profiles of pregnancy malnutrition induced by feed restriction (FR) and the counteracting effects of glycerol and rumen-protected choline chloride supplementation." | 3.96 | Urine metabolome alterations in malnutrition and the impact of glycerol or rumen-protected choline chloride supplementation in advanced pregnant ewes. ( Guo, C; Hu, F; Mao, S; Xuan, H; Xue, Y; Yin, Y, 2020) |
| "Choline content of diets that are consumed by rats during pregnancy affects the later-life phenotype of offspring, associated with altered in utero programing of hypothalamic food intake regulation." | 3.96 | Maternal Choline Intake Programs Hypothalamic Energy Regulation and Later-Life Phenotype of Male Wistar Rat Offspring. ( Anderson, GH; Caudill, MA; Chatterjee, D; Hammoud, R; Ho, M; Kubant, R; Liao, CS; Malysheva, OV; Pannia, E; Pausova, Z; Yang, NV, 2020) |
| "We aimed to determine the effect of feeding buttermilk-derived choline forms during pregnancy and lactation on maternal immune function." | 3.96 | Feeding Buttermilk-Derived Choline Forms During Gestation and Lactation Modulates Ex Vivo T-Cell Response in Rat Dams. ( Azarcoya-Barrera, J; Curtis, JM; Field, CJ; Goruk, S; Jacobs, RL; Lewis, ED; Pouliot, Y; Richard, C; Steele, R; Wadge, E, 2020) |
| " Plasma choline levels were measured at 16 weeks gestation in 43 mothers who had contracted common respiratory viruses during the first 6-16 weeks of pregnancy and 53 mothers who had not." | 3.96 | Maternal choline and respiratory coronavirus effects on fetal brain development. ( Camille Hoffman, M; D'Alessandro, A; Freedman, R; Hunter, SK; Law, AJ; Noonan, K; Wyrwa, A, 2020) |
| " Using LC-MS/MS, we found a higher ratio of levels of LPA and its precursor lysophosphatidylcholine (LPC) in AF collected after parturition than that in AF collected at the middle stage of pregnancy." | 3.96 | Distinct contributions of two choline-producing enzymatic activities to lysophosphatidic acid production in human amniotic fluid from pregnant women in the second trimester and after parturition. ( Fukui, M; Irahara, M; Iwasa, T; Kuwahara, A; Morito, K; Tanaka, T; Tokumura, A; Tsutsumi, T; Yamamoto-Mikami, A, 2020) |
| "Compared with the lowest quartile of choline intake, women within the highest consumption quartile had adjusted odds ratio (aOR) for preterm birth of 0." | 3.96 | Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study. ( Cai, W; He, XL; Kohlmeier, M; Liu, YH; Shen, LW; Tang, QY; Wang, B; Yi, XX; Zhou, LL; Zhu, J, 2020) |
| "The importance of ensuring adequate choline intakes during pregnancy is increasingly recognized." | 3.91 | Choline: Exploring the Growing Science on Its Benefits for Moms and Babies. ( Caudill, MA; Jiang, X; Korsmo, HW, 2019) |
| "Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD)." | 3.91 | Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ginsberg, SD; Kelley, CM; Mufson, EJ; Strupp, BJ, 2019) |
| "Lipopolysaccharide significantly increased SBP and urinary albumin and decreased pregnancy outcomes, and these effects were partially reversed by higher choline treatment." | 3.88 | Choline Supplementation During Pregnancy Protects Against Gestational Lipopolysaccharide-Induced Inflammatory Responses. ( Bao, J; Garfield, RE; Han, X; Liu, H; Shi, SQ; Yang, J; Zhang, M, 2018) |
| "Compared to nonpregnant women, women with normal pregnancy and preeclampsia had lower levels of the cerebral osmolytes, myo-inositol, choline and creatine (P = 0." | 3.88 | Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study. ( Bergman, L; Larsson, A; Nelander, M; Sundström-Poromaa, I; Weis, J; Wikström, AK; Wikström, J, 2018) |
| "Both insufficiency and excess of one-carbon nutrients (folate, choline, vitamins B6 and B12) during pregnancy have been associated with gestational diabetes mellitus (GDM)." | 3.88 | Fetal one-carbon nutrient concentrations may be affected by gestational diabetes. ( Barzilay, E; Berger, H; Caudill, MA; Croxford, R; Kim, YI; Ly, A; Malysheva, O; Masih, SP; Moon, A; O'Connor, DL; Plumptre, L; Sohn, KJ; Visentin, CE, 2018) |
| "Although animal and human studies have demonstrated interactions between dietary choline and fetal alcohol spectrum disorders, dietary choline deficiency in pregnancy is common in the US and worldwide." | 3.88 | Development and validation of a quantitative choline food frequency questionnaire for use with drinking and non-drinking pregnant women in Cape Town, South Africa. ( Bechard, LJ; Booley, S; Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Najaar, B; Senekal, M, 2018) |
| "This study suggests that higher maternal plasma choline status during pregnancy is associated with more symptoms of antenatal depression and anxiety, whereas plasma betaine concentrations showed no associations." | 3.85 | Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort. ( Chen, H; Chong, MF; Chong, YS; Godfrey, KM; Meaney, MJ; Quah, PL; Saw, SM; van Lee, L; Yap, FKP, 2017) |
| " We evaluated maternal methyl-group donor intake through diet (methionine, betaine, choline, folate) and supplementation (folic acid) before and during pregnancy in relation to global DNA methylation and hydroxymethylation and gene specific (IGF2 DMR, DNMT1, LEP, RXRA) cord blood methylation." | 3.85 | Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation. ( A S Langie, S; Bekaert, B; Devlieger, R; Duca, RC; Freson, K; Ghosh, M; Godderis, L; Huybrechts, I; Koppen, G; Pauwels, S, 2017) |
| "The Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD) exhibits cognitive impairment and degeneration of basal forebrain cholinergic neurons (BFCNs)." | 3.85 | Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, MS; Strupp, BJ; Velazquez, R, 2017) |
| "Proportion of women with dietary intakes below Estimated Average Requirement (EAR) or Adequate Intake (AI) for vitamin D, folate, iron, calcium, and choline throughout pregnancy." | 3.85 | Micronutrient Intake Is Inadequate for a Sample of Pregnant African-American Women. ( Block, RC; Fernandez, ID; Groth, SW; Ossip, DJ; Stewart, PA; Wixom, N, 2017) |
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 3.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration." | 3.83 | Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016) |
| " A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation." | 3.83 | Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. ( Alldred, MJ; Ash, JA; Caudill, MA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, M; Strupp, BJ; Velazquez, R, 2016) |
| " We used questionnaires to ascertain pre-pregnancy supplementation and estimate usual maternal dietary intake of folate, choline, and folic acid." | 3.83 | A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group. ( Basta, PV; Carrier, KS; Diskin, SJ; Engel, SM; Maris, JM; Maxen, C; Mazul, AL; Naranjo, A; Olshan, AF; Siega-Riz, AM; Vaksman, Z; Weinberg, CR; Zou, F, 2016) |
| "We examined whether perinatal maternal dietary choline deficiency influences porcine-milk composition." | 3.83 | Perinatal Dietary Choline Deficiency in Sows Influences Concentrations of Choline Metabolites, Fatty Acids, and Amino Acids in Milk throughout Lactation. ( Alexander, LS; Caudill, MA; Dilger, RN; Getty, CM; Johnson, SK; Malysheva, OV; Mudd, AT, 2016) |
| "Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects." | 3.81 | Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. ( Berger, H; Caudill, MA; Croxford, R; El-Sohemy, A; Kim, YI; Lausman, AY; Ly, A; Malysheva, O; Masih, S; Nielsen, DE; O'Connor, DL; Plumptre, L; Sohn, KJ; Visentin, CE, 2015) |
| "Folate, vitamin B-6, vitamin B-12, and choline are involved in one-carbon metabolism and play critical roles in pregnancy including prevention of birth defects and promotion of neurodevelopment." | 3.81 | Pregnant Canadian Women Achieve Recommended Intakes of One-Carbon Nutrients through Prenatal Supplementation but the Supplement Composition, Including Choline, Requires Reconsideration. ( Berger, H; Croxford, R; Kim, YI; Lausman, AY; Ly, A; Masih, SP; O'Connor, DL; Plumptre, L, 2015) |
| " Women who differed in prenatal alcohol use were recruited during pregnancy and assigned to a group (No study-provided supplements, multivitamin/mineral supplement, or multivitamin/mineral supplement plus choline supplement)." | 3.81 | The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. ( Chambers, CD; Coles, CD; Jones, KL; Kable, JA; Keen, CL; Kulikovsky, Y; Pedersen, TL; Uriu-Adams, JY; Wertelecki, W; Yevtushok, L, 2015) |
| "Down syndrome (DS), trisomy 21, is a multifaceted condition marked by intellectual disability and early presentation of Alzheimer's disease (AD) neuropathological lesions including degeneration of the basal forebrain cholinergic neuron (BFCN) system." | 3.80 | Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014) |
| " Female C3H control and tx-j mice were fed control (choline 8 mmol/Kg of diet) or choline-supplemented (choline 36 mmol/Kg of diet) diets for 2 weeks throughout mating and pregnancy to gestation day 17." | 3.80 | Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. ( French, SW; Halsted, CH; Islam, MS; Keen, CL; Kharbanda, KK; Kim, K; LaSalle, JM; Medici, V; Shibata, NM; Tillman, B, 2014) |
| "Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs)." | 3.80 | Dietary intake of choline and neural tube defects in Mexican Americans. ( Brender, JD; Canfield, MA; Felkner, M; Lavery, AM; Suarez, L; Sweeney, A; Zhao, H, 2014) |
| "Despite recommendations for higher choline intakes during pregnancy and lactation, there is limited research regarding maternal intake during these important periods." | 3.80 | Estimation of choline intake from 24 h dietary intake recalls and contribution of egg and milk consumption to intake among pregnant and lactating women in Alberta. ( Bell, RC; Curtis, JM; Field, CJ; Jacobs, RL; Lewis, ED; McCargar, LJ; Subhan, FB, 2014) |
| "Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration." | 3.80 | Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014) |
| "Maternal choline supplementation (MCS) induces lifelong cognitive benefits in the Ts65Dn mouse, a trisomic mouse model of Down syndrome and Alzheimer's disease." | 3.80 | Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice. ( Alldred, MJ; Caudill, MA; Ginsberg, SD; Powers, B; Saltzman, A; Strupp, BJ; Yan, J, 2014) |
| " Female Wistar rats fed control diet during pregnancy were assigned to four postpartum dietary groups: control, control supplemented with methyl donors (choline, betaine, folic acid, vitamin B12), HFS and HFS supplemented with methyl donors." | 3.80 | Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet. ( Campion, J; Cordero, P; Martinez, JA; Milagro, FI, 2014) |
| " Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years." | 3.79 | Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013) |
| "The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy." | 3.79 | Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. ( Ballesteros, M; Berrocal-Zaragoza, MI; Cavallé-Busquets, P; Fernandez-Ballart, JD; Fernàndez-Roig, S; Murphy, MM; Salat-Batlle, J; Ueland, PM, 2013) |
| "Choline needs are increased in pregnancy." | 3.79 | Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013) |
| "Reduced folate and choline status resulted in severe fetal growth restriction (FGR) and impaired fertility in litters harvested from Mthfd1(gt/+) dams, but embryonic Mthfd1(gt/+) genotype did not affect fetal growth." | 3.78 | Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. ( Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ, 2012) |
| " We examined the associations of maternal intake of folate, vitamin B12, choline, betaine and methionine during the first and second trimesters of pregnancy, with tests of cognitive performance in the offspring at 3 years of age using data from 1210 participants in Project Viva, a prospective pre-birth cohort study in Massachusetts." | 3.78 | Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. ( Gillman, MW; Oken, E; Rifas-Shiman, SL; Villamor, E, 2012) |
| "We show that choline status in the first half of pregnancy is associated with cognitive development among healthy term gestation infants." | 3.78 | Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. ( Dyer, RA; Innis, SM; King, DJ; Richardson, KJ; Wu, BT, 2012) |
| ") of saline (control) or kainic acid to induce seizures and were euthanized 16 days later." | 3.77 | Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. ( Blusztajn, JK; Glenn, MJ; Mellott, TJ; Tognoni, CM; Williams, CL; Wong-Goodrich, SJ, 2011) |
| "We examined whether hypospadias is associated with maternal intake of folic acid containing vitamin/mineral supplements or dietary intake of nutrients related to one-carbon metabolism (folate, choline, vitamins B12 and B6, thiamine, riboflavin, methionine and zinc)." | 3.75 | Hypospadias and intake of nutrients related to one-carbon metabolism. ( Carmichael, SL; Correa, A; Olney, RS; Shaw, GM; Yang, W, 2009) |
| "An increased supply of the essential nutrient choline during fetal development [embryonic day (E) 11-17] in rats causes life-long improvements in memory performance, whereas choline deficiency during this time impairs certain aspects of memory." | 3.74 | Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. ( Blusztajn, JK; Diesl, V; Follettie, MT; Hill, AA; Lopez-Coviella, I; Mellott, TJ, 2007) |
| "Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers." | 3.74 | Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. ( Berger-Sweeney, JE; Nag, N, 2007) |
| "Supplementation of maternal diet with the essential nutrient, choline, during the second half of pregnancy in rats causes long-lasting improvements in spatial memory in the offspring and protects them from the memory decline characteristic of old age." | 3.74 | Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. ( Blusztajn, JK; Kowall, NW; Lopez-Coviella, I; Mellott, TJ, 2007) |
| " We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation." | 3.74 | A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats. ( Os'kina, IN; Plyusnina, IZ; Prasolova, LA; Shchepina, OA; Trut, LN, 2007) |
| "Prenatal choline supplementation (SUP) protects adult rats against spatial memory deficits observed after excitotoxin-induced status epilepticus (SE)." | 3.74 | Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. ( Blusztajn, JK; Glenn, MJ; Mellott, TJ; Williams, CL; Wong-Goodrich, SJ, 2008) |
| "Animal studies indicate that maternal prenatal choline supplementation leads to permanent enhancement of attention and spatial memory abilities in offspring, whereas dietary choline restriction during pregnancy impairs cognitive function in offspring." | 3.74 | Choline concentrations in human maternal and cord blood and intelligence at 5 y of age. ( Mills, JL; Signore, C; Troendle, J; Ueland, PM, 2008) |
| "We investigated the courses of plasma choline and betaine during normal human pregnancy and their relations to plasma tHcy." | 3.73 | Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy. ( Fokkema, MR; Holm, PI; Muskiet, FA; Ueland, PM; van der Dijs, FP; Velzing-Aarts, FV, 2005) |
| "Little is known about the interactions between choline and folate and homocysteine metabolism during pregnancy despite the facts that pregnancy places considerable stress on maternal folate and choline stores and that choline is a critical nutrient for the fetus." | 3.73 | Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. ( Brody, LC; Conley, M; Cox, C; Daly, SF; Kirke, PN; Mills, JL; Molloy, AM; Scott, JM; Ueland, PM, 2005) |
| "Choline is an essential nutrient for humans and its availability during pregnancy is important for optimal fetal development." | 3.73 | Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica. ( Fletcher, H; Gossell-Williams, M; Jacob, A; McFarlane-Anderson, N; Patel, J; Zeisel, S, 2005) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 3.72 | Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003) |
| "Female Sprague-Dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age." | 3.71 | Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. ( Loy, R; Sandstrom, NJ; Williams, CL, 2002) |
| "Treatment of rats with choline during brain development results in long-lasting enhancement of spatial memory whereas choline deficiency has the opposite effect." | 3.71 | Choline deficiency induces apoptosis in primary cultures of fetal neurons. ( Fernandes, A; Mar, MH; Meeker, RB; Yen, CL; Zeisel, SH, 2001) |
| "Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J." | 3.71 | Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Yang, Y, 2002) |
| "Pregnancy is associated with increased phosphatidylcholine (PC) 16:0/22:6 and PC16:0/20:4 concentrations in rat liver and plasma, guinea-pig liver, and in plasma in women." | 3.70 | Pregnancy-associated adaptations to hepatic phosphatidylcholine biosynthesis in the guinea-pig. ( Burdge, GC; Postle, AD, 1998) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 3.70 | Choline availability alters embryonic development of the hippocampus and septum in the rat. ( Albright, CD; Friedrich, CB; Mar, MH; Tsai, AY; Zeisel, SH, 1999) |
| "Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring." | 3.70 | Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. ( Jones, JP; Meck, WH; Swartzwelder, HS; Williams, CL; Wilson, WA, 1999) |
| "The objectives of the present study were to determine the effects of rumen undegradable protein (RUP) level of prepartum diets, the supplementation of a rumen-protected choline product, and their interactions on milk production, feed intake, body weight and condition, blood metabolites, and liver triacylglycerides in dairy cows." | 3.70 | Impact of dietary rumen undegradable protein and rumen-protected choline on intake, peripartum liver triacylglyceride, plasma metabolites and milk production in transition dairy cows. ( Cecava, MJ; Donkin, SS; Hartwell, JR, 2000) |
| "Choline supplementation of pregnant rats between d 12 and 17 of pregnancy permanently enhances the spatial memory of offspring; however, the mechanism is unknown." | 3.69 | Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. ( Garner, SC; Mar, MH; Zeisel, SH, 1995) |
| "Late pregnancy in the rat (gestational ages 16-21 days) was accompanied by a specific increase in hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) molecular species containing C16:0 at the sn-1 position and polyunsaturated essential fatty acids (PUFA), in particular C22:6(n-3), at the sn-2 position." | 3.69 | Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy. ( Burdge, GC; Hunt, AN; Postle, AD, 1994) |
| "Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring." | 3.69 | Dietary choline supplementation in pregnant rats increases hippocampal phospholipase D activity of the offspring. ( Blusztajn, JK; Cermak, JM; Holler, T, 1996) |
| "To analyze whether human cytomegalovirus could induce changes in membrane permeability we studied both Hygromycin B (HyB) inhibition of protein synthesis and glycine and choline uptake during viral replication." | 3.67 | Changes in membrane permeability in cells infected by human cytomegalovirus. ( Baldassarri, B; Landini, MP; Rugolo, M, 1986) |
| " Experimental evidence obtained in rats suggest that the precipitous fall in maternal liver choline concentration nearing the end of pregnancy could lead to a severe reduction in the lipotropic activity of the liver." | 3.66 | Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency? ( Gwee, MC, 1982) |
| "Lithium treatment can affect the transport of choline and lithium ions across cell membranes, but little is known about these effects during pregnancy." | 3.66 | Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport. ( Erstling, C; Hanin, I; Kopp, U; Mallinger, AG; Mallinger, J; Stumpf, RL, 1983) |
| "Micronutrition in pregnancy is critical to impact not only fetal growth and development but also long-term physical and psychiatric health outcomes." | 3.30 | Micronutrient Gaps and Supplement Use in a Diverse Cohort of Pregnant Women. ( Brown, AR; Carlson, SE; Crawford, SA; Gajewski, BJ; Kerling, EH; Sullivan, DK; Teruel Camargo, J; Valentine, CJ, 2023) |
| "Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder." | 3.11 | Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes. ( Anthony, ME; Boys, CJ; de Water, E; Eckerle, JK; Ernst, AM; Fuglestad, AJ; Georgieff, MK; Gimbel, BA; Mueller, BA; Radke, JP; Roediger, DJ; Wozniak, JR; Zeisel, SH, 2022) |
| "Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits." | 2.94 | Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Lindgren, C; Miller, NC; Radke, JP; Sandness, KE; Wozniak, JR; Zeisel, SH, 2020) |
| "This study investigated the effects of dietary inclusion of rumen-protected methionine alone or in combination with rumen-protected choline and betaine on: (i) milk yield, chemical composition and fatty acids (FA) profile and (ii) blood plasma glutathione transferase (GST) activity of periparturient ewes." | 2.84 | The effect of dietary supplementation with rumen-protected methionine alone or in combination with rumen-protected choline and betaine on sheep milk and antioxidant capacity. ( Chatzikonstantinou, M; Kalogeropoulos, T; Koutsouli, P; Labrou, N; Mavrommatis, A; Sotirakoglou, K; Tsiplakou, E; Zervas, G, 2017) |
| "There are no biological treatments for fetal alcohol spectrum disorders (FASDs), lifelong conditions associated with physical anomalies, brain damage, and neurocognitive abnormalities." | 2.78 | Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Hoecker, HL; Kroupina, MG; Miller, NC; Wozniak, JR; Zeisel, SH, 2013) |
| " As an extension of a 12-wk dose-response choline feeding study conducted in third-trimester pregnant women, we investigated the effect of maternal choline intake (930 vs." | 2.77 | Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans. ( Caudill, MA; Devapatla, S; Jiang, X; Malysheva, OV; Perry, CA; Pressman, E; Vermeylen, F; West, AA; Yan, J, 2012) |
| "Choline is an important nutrient during the first 1000 days post conception due to its roles in brain function." | 2.72 | Habitual Choline Intakes across the Childbearing Years: A Review. ( Derbyshire, E; Obeid, R; Schön, C, 2021) |
| "Choline is a critical nutrient for cognitive development, metabolism and liver function, and regulation of homocysteine metabolism." | 2.72 | [Importance of choline in cognitive function]. ( Aparicio, A; López-Sobaler, AM; Lorenzo Mora, AM; Ortega, RMª; Peral Suárez, Á; Salas González, MªD, 2021) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide." | 2.66 | One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020) |
| "Choline is an essential nutrient for proper liver, muscle, and brain functions as well as for lipid metabolism and cellular membrane composition and repair." | 2.66 | Choline: The Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists. ( Blusztajn, JK; Caudill, MA; Klatt, KC; Wallace, TC; Zeisel, SH, 2020) |
| "Choline interventions were administered at different times relative to alcohol exposure, impacting on their success to prevent deficits for specific outcomes." | 2.58 | Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies. ( Akison, LK; Boyd, RN; Kuo, J; Moritz, KM; Reid, N, 2018) |
| " However, the effects of RPC on health and reproduction are equivocal, which could reflect the lack of sufficient dose-response studies." | 2.53 | The role of rumen-protected choline in hepatic function and performance of transition dairy cows. ( Al Jassim, R; D'Occhio, MJ; Shahsavari, A, 2016) |
| "Down syndrome affects more than 5 million people globally." | 2.50 | Prenatal treatment of Down syndrome: a reality? ( Bianchi, DW; Delabar, JM; Guedj, F, 2014) |
| "Choline is an essential nutrient for humans." | 2.48 | Choline nutrition programs brain development via DNA and histone methylation. ( Blusztajn, JK; Mellott, TJ, 2012) |
| "Choline is an essential nutrient with a wide range of biological functions, and current studies are aimed at refining our understanding of its requirements and, importantly, on defining the molecular mechanisms that mediate its effects in instances of suboptimal dietary intake." | 2.48 | The nutrigenetics and nutrigenomics of the dietary requirement for choline. ( Corbin, KD; Zeisel, SH, 2012) |
| "Choline is an essential nutrient in humans, and is an important methyl group donor." | 2.47 | What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. ( Zeisel, SH, 2011) |
| "Choline is a quaternary amine endogenously synthesized from the amino acid methionine or absorbed via the portal circulation." | 2.45 | The addition of choline to parenteral nutrition. ( Buchman, AL, 2009) |
| "Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998." | 2.45 | Choline: an essential nutrient for public health. ( da Costa, KA; Zeisel, SH, 2009) |
| "Choline is an essential nutrient needed for the structural integrity and signaling functions of cell membranes; for normal cholinergic neurotransmission; for normal muscle function; for lipid transport from liver; and it is the major source of methyl groups in the diet." | 2.43 | Choline: critical role during fetal development and dietary requirements in adults. ( Zeisel, SH, 2006) |
| "Choline is a dietary component essential for normal function of all cells." | 2.42 | Nutritional importance of choline for brain development. ( Zeisel, SH, 2004) |
| "Choline is a dietary component essential for normal function of all cells." | 2.41 | Choline: needed for normal development of memory. ( Zeisel, SH, 2000) |
| "Choline is a semi-essential nutrient involved in lipid and one-carbon metabolism that is compromised during MAFLD progression." | 1.91 | Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes. ( Bretter, R; Caviglia, JM; Jiang, X; Johnson, CH; Kadam, I; Korsmo, HW; Reaz, A; Saxena, A, 2023) |
| "Mean choline levels were higher in CHD compared with controls (CHD 2." | 1.91 | Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease. ( Andescavage, NN; Cheng, JJ; Donofrio, MT; du Plessis, AJ; Gimovsky, AC; Kapse, K; Limperopoulos, C; Pradhan, S; Sharker, Y; Wessel, D, 2023) |
| "Individuals with fetal alcohol spectrum disorders (FASD) incur enduring brain damage and neurodevelopmental impairments from prenatal alcohol exposure (PAE)." | 1.72 | The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent. ( Carugati, M; Cudd, TA; Goodlett, CR; Washburn, SE, 2022) |
| "Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear." | 1.72 | Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes. ( Cao, Y; Chang, X; Dai, Y; Guo, J; Liang, W; Lu, D; Lv, S; Qi, X; Wang, Z; Wu, C; Zhang, J; Zhang, L; Zhou, Z, 2022) |
| " Restricted cubic splines were plotted to evaluate the dose-response relationship between dietary OCM-related nutrient intake and the risk of PE." | 1.72 | One-carbon metabolism-related nutrients intake is associated with lower risk of preeclampsia in pregnant women: a matched case-control study. ( Bo, Y; Cao, Y; Dou, W; Duan, D; Fu, W; Liu, Y; Lyu, Q; Ma, S; Zeng, F; Zhao, X, 2022) |
| "Choline is an essential nutrient under evaluation as a cognitive enhancing treatment for fetal alcohol spectrum disorders (FASD) in clinical trials." | 1.62 | Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. ( Christie, BR; Fontaine, CJ; Grafe, EL; Thomas, JD, 2021) |
| "Choline is an essential nutrient and a primary dietary source of methyl groups that are vital for brain development." | 1.62 | Low Maternal Dietary Intake of Choline Regulates Toll-Like Receptor 4 Expression Via Histone H3K27me3 in Fetal Mouse Neural Progenitor Cells. ( Bai, Y; Chen, X; Dai, L; Guan, X; Ma, J; Qu, S; Wang, Y; Zhang, Q, 2021) |
| " Additional larger, dose-response DHA trials accounting for usual intakes and baseline DHA status are needed to determine how to best achieve target breast milk DHA levels and to identify additional modifiers of the variable breast milk DHA response to maternal DHA supplementation." | 1.62 | Baseline red blood cell and breast milk DHA levels affect responses to standard dose of DHA in lactating women on a controlled feeding diet. ( Caudill, MA; Harris, WS; Jackson, KH; Klatt, KC; Malysheva, OV; McDougall, MQ; Perry, CA; West, AA, 2021) |
| "Choline is a key nutrient in fetal brain development." | 1.62 | Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. ( Balser, M; D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Walker, VK, 2021) |
| "The cholinergic system plays a crucial role in learning and memory processes." | 1.56 | Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats. ( Hill, E; Jiang, L; Mooney, SM; Tang, S; Waddell, J; Xu, S, 2020) |
| "Choline (5ppm) was given to half the nursing dams and weanlings in each group from P11-P30." | 1.48 | Beneficial effects of postnatal choline supplementation on long-Term neurocognitive deficit resulting from fetal-Neonatal iron deficiency. ( Georgieff, MK; Gewirtz, JC; Kennedy, BC; Kohli, M; Maertens, JJ; Tran, PV, 2018) |
| "Birth weight was higher in the G allele homozygotes of the CHDH rs2289205 than in the minor allele carriers: GG: 3398 ± 64 g; GA+AA: 3193 ± 76 g." | 1.48 | PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women. ( Barlik, M; Chmurzynska, A; Drews, K; Jagodziński, PP; Kurzawińska, G; Malinowska, AM; Radziejewska, A; Różycka, A; Seremak-Mrozikiewicz, A; Szwengiel, A, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis." | 1.46 | Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. ( Alfaro, M; Chintapalli, SV; Kang, P; Shankar, K; Thakali, KM; Wankhade, UD; Zhong, Y, 2017) |
| "Choline has been shown to mediate damage of the chondrocyte matrix and degradation enzymes of mice exposed to fluoride (F)." | 1.46 | Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride. ( Hao, J; Wang, J; Zhao, Y, 2017) |
| "Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences." | 1.46 | Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. ( Blusztajn, JK; Huleatt, OM; Liu, YB; Mellott, TJ; Pender, SM; Shade, BN; Slack, BE, 2017) |
| "Choline (5 g/kg) was given to half the pregnant dams in each group from G11 to G18." | 1.43 | Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus. ( Georgieff, MK; Gewirtz, JC; Kennedy, BC; Pisansky, MT; Simmons, RA; Tran, PV; Won, KJ, 2016) |
| "Choline treatment failed to attenuate alcohol-related overactivity in the open field and deficits in Morris water maze performance." | 1.43 | Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent. ( Schneider, RD; Thomas, JD, 2016) |
| "Choline is an essential nutrient that is required for normal development of the brain." | 1.43 | Choline and the Brain: An Epigenetic Perspective. ( Bekdash, RA, 2016) |
| "Choline is a fundamental nutrient for brain development and high choline intake during prenatal and/or early postnatal periods is neuroprotective." | 1.42 | High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism. ( Blusztajn, JK; Krykbaeva, M; Langley, EA; Mellott, TJ, 2015) |
| "Choline pre-treatment increased the distance crossed by males, and both pre- and post-treatment with choline significantly increased total distance crossed for females and males." | 1.42 | Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure. ( Bearer, CF; He, M; Mooney, SM; Tang, N; Wellmann, KA, 2015) |
| "Choline is a precursor to phosphatidylcholine (PC), a structural molecule in cellular membranes that is crucial for cell growth and function." | 1.42 | Choline deficiency impairs intestinal lipid metabolism in the lactating rat. ( Curtis, JM; da Silva, RP; Field, CJ; Goruk, S; Jacobs, RL; Kelly, KB; Leonard, KA; Lewis, ED; Proctor, SD; Vine, DF, 2015) |
| "In healthy term newborns with chorioamnionitis, MRS ratios shortly after birth may provide evidence of occult neuroinflammation, which may be associated with worse performance on 1-year neurodevelopmental tests." | 1.42 | Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis. ( Bentzley, JP; Brown, T; Hope, K; Jenkins, DD; Johnson, CB; Katikaneni, LD; Lambert, D; Morgan, PS; Mulvihill, DM; Ramakrishnan, V; Rollins, LG, 2015) |
| "Choline is an important component of human breast milk and its content varies considerably among breastfeeding women and lactation periods." | 1.40 | Breast milk choline contents are associated with inflammatory status of breastfeeding women. ( Cansev, M; Ozarda, Y; Ulus, IH, 2014) |
| " Dosing solutions were adjusted by maternal body weight to provide 30, 70, or 100 mg/kg RA." | 1.40 | Metabolic characterization of all-trans-retinoic acid (ATRA)-induced craniofacial development of murine embryos using in vivo proton magnetic resonance spectroscopy. ( Hu, X; Peng, L; Qin, F; Shen, Z; Tang, S; Wu, R; Zhang, G, 2014) |
| "Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development." | 1.39 | Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. ( Blom, HJ; den Heijer, M; Hogeveen, M; Semmekrot, BA; Sporken, JM; Ueland, PM, 2013) |
| "Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system." | 1.39 | Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. ( Bonham, MP; Davidson, PW; Henderson, J; Kobrosly, RW; McAfee, AJ; McSorley, EM; Mulhern, MS; Myers, GJ; Shamlaye, CF; Strain, JJ; Thurston, SW; Ueland, PM; van Wijngaarden, E; Wallace, JM; Watson, GE, 2013) |
| "Choline is an essential nutrient required for early development." | 1.39 | Long-lasting effects of prenatal dietary choline availability on object recognition memory ability in adult rats. ( Carias, D; de Brugada, I; Gallo, M; Moreno, HC, 2013) |
| "Choline has been shown to have direct BP-reducing effects in humans and animals." | 1.38 | Increased systolic blood pressure in rat offspring following a maternal low-protein diet is normalized by maternal dietary choline supplementation. ( Bai, SY; Briggs, DI; Vickers, MH, 2012) |
| "Lumbosacral spina bifida is a common debilitating birth defect whose multiple causes are poorly understood." | 1.38 | Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. ( Capecchi, MR; Gahring, LC; Rogers, SW; Tvrdik, P, 2012) |
| "Choline or saline was administered subcutaneously to each subject from postnatal days 2 to 20." | 1.38 | Choline supplementation and DNA methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development. ( Kelly, SJ; Otero, NK; Saski, CA; Thomas, JD; Xia, X, 2012) |
| "Dystocia is a major problem for the dairy cattle industry, and the observed high rates of this condition stem from genetic selection to increase subsequent milk production of the calving female." | 1.38 | The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins. ( Sugimoto, M; Sugimoto, Y; Watanabe, T, 2012) |
| "Low choline intake is a major risk factor for liver and several neurological disorders." | 1.37 | Use of canonical variate analysis biplot in examination of choline content data of some foods. ( Alkan, B; Atakan, C, 2011) |
| "Colitis was induced by dextran sulfate sodium." | 1.37 | Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. ( Dowd, SE; Harris, RA; Kellermayer, R; Schaible, TD; Smith, CW, 2011) |
| "Choline is an essential nutrient that influences brain and behavioral development." | 1.36 | Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. ( Dominguez, HD; Idrus, NM; Monk, BR; Thomas, JD, 2010) |
| "Choline is a selective agonist for the alpha7 nicotinic receptor which appears in development before acetylcholine is present." | 1.35 | Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. ( Adams, CE; Kisley, MA; Mellott, TJ; Robbins, E; Stevens, KE, 2008) |
| "Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects." | 1.35 | Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. ( Blusztajn, JK; Mellott, TJ; Napoli, I, 2008) |
| "Diethanolamine (DEA) is a common ingredient of personal care products." | 1.35 | Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans. ( Craciunescu, CN; Fischer, L; Guo, Z; Johnson, AR; Niculescu, MD; Zeisel, SH, 2009) |
| "Choline is an essential nutrient that, via its metabolite betaine, serves as a donor of methyl groups used in fetal development to establish the epigenetic DNA and histone methylation patterns." | 1.35 | Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. ( Blusztajn, JK; Davison, JM; Kovacheva, VP; Mellott, TJ, 2009) |
| "Choline is an essential nutrient that serves as a donor of metabolic methyl groups used during gestation to establish the epigenetic DNA methylation patterns that modulate tissue-specific gene expression." | 1.35 | Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. ( Blusztajn, JK; Davison, JM; Kovacheva, VP; Mellott, TJ; O'Brien, MJ; Rogers, AE; Yang, S, 2009) |
| "Choline is an essential nutrient for phospholipids and acetylcholine biosynthesis in normal development of fetus." | 1.35 | Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT. ( Choi, HM; Kang, YS; Lee, NY, 2009) |
| "The association of chorioamnionitis and noncystic white matter injury, a common brain injury in premature newborns, remains controversial." | 1.35 | Effect of chorioamnionitis on brain development and injury in premature newborns. ( Bowen-Roberts, T; Brant, R; Chau, V; McFadden, DE; Miller, SP; Poskitt, KJ; Sargent, MA; Soulikias, W; Synnes, A, 2009) |
| "Diethanolamine (DEA) is a widely used ingredient in many consumer products and in a number of industrial applications." | 1.34 | Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells. ( da Costa, KA; Guo, Z; Niculescu, MD; Wu, R; Zeisel, SH, 2007) |
| "In women with partial hydatidiform mole, the only detectable signal was choline." | 1.33 | Magnetic resonance spectroscopy of premalignant and malignant endometrial disorders: a feasibility of in vivo study. ( Alkan, A; Celik, O; Hascalik, S; Meydanli, MM; Mizrak, B; Sarac, K, 2005) |
| "Three of them had fetal alcohol syndrome (FAS), 3 had partial FAS (PFAS), and 4 had alcohol-related neurobehavioral disorder (ARND)." | 1.33 | Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders. ( Autti-Rämö, I; Fagerlund, A; Heikkinen, S; Korkman, M; Kuusi, T; Lundbom, N; Riley, EP; Timonen, M, 2006) |
| "Choline is an essential nutrient and it is also a methyl donor critical for the maintenance of cell membrane integrity and methyl metabolism." | 1.33 | CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. ( Enaw, JO; Finnell, RH; Lammer, EJ; Lu, W; Shaw, GM; Yang, W; Zhu, H, 2006) |
| "Choline is an essential nutrient for humans and is derived from the diet as well as from de novo synthesis involving methylation of phosphatidylethanolamine catalysed by the enzyme phosphatidylethanolamine N -methyltransferase (PEMT)." | 1.32 | Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. ( Edwards, LJ; Mar, MH; Song, J; Zeisel, SH; Zhu, X, 2003) |
| "Gestational diabetes is a metabolic disorder affecting 2-5% of women and is a predictor of obesity, Type 2 diabetes mellitus and cardiovascular disease." | 1.32 | Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes. ( Crawford, MA; Ghebremeskel, K; Lowy, C; Min, Y; Thomas, B, 2004) |
| "Choline is an essential nutrient for animals and humans." | 1.32 | Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. ( Blusztajn, JK; Meck, WH; Mellott, TJ; Williams, CL, 2004) |
| "Choline is a nutrient in milk that is essential for the nourishment and growth of newborns." | 1.32 | Hormone regulation of choline uptake and incorporation in mouse mammary gland explants. ( Rillema, JA, 2004) |
| "Choline is a required nutrient and is derived from the diet as well as from de novo synthesis catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT)." | 1.32 | Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus. ( Mar, MH; Song, J; Zeisel, SH; Zhu, X, 2004) |
| "Murine trisomy 16 is an animal model of human Down's syndrome." | 1.31 | Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice. ( Allen, DD; Arriagada, C; Cárdenas, AM; Caviedes, P; Caviedes, R; Martín, J; Rapoport, SI, 2000) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| "Choline is an essential nutrient in methylation, acetylcholine and phospholipid biosynthesis, and in cell signaling." | 1.31 | Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. ( Fisher, MC; Mar, MH; Sadler, TW; Zeisel, SH, 2001) |
| "Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging." | 1.31 | Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome. ( Barker, PB; Beauchamp, NJ; Eichler, FS; Wang, P; Wityk, RJ, 2002) |
| "Choline incorporation was significantly lower after a 4-hour pulse in low glucose (+/- insulin) than under continuing high glucose (+/- insulin) conditions (P < ." | 1.30 | Effect of acute glucose depletion following glucose excess on surfactant phospholipid synthesis in developing fetal lung. ( Gewolb, IH; Marwah, GS; O'Brien, J, 1999) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 1.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| " Chronic administration of retinyl palmitate to the mother from day 16 through 20 increased disaturated PC content on day 21 but decreased SP-A concentration." | 1.29 | Retinoids control surfactant phospholipid biosynthesis in fetal rat lung. ( Bourbon, JR; Fraslon, C, 1994) |
| "Myo-inositol was found dominating the spectra at birth (12 mmoles/kg), while choline is responsible for the strongest peak in older infants (2." | 1.29 | Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. ( Ernst, T; Kreis, R; Ross, BD, 1993) |
| "Significant correlations with maternal preeclampsia and fetal open spina bifida were also observed." | 1.29 | Metabolic profiling of amniotic fluid by proton nuclear magnetic resonance spectroscopy: correlation with fetal maturation and other clinical variables. ( Bock, JL, 1994) |
| "The choline effect was first observable at concentrations of 105 mM." | 1.29 | Influence of organic cations on basic amino-acid uptake by human placental villi. ( Dancis, J; Krishna, RB; Levitz, M, 1995) |
| " Ruminal dosing of steers with 27 g/d supplemental choline in Experiment 3 increased duodenal choline flow by only 3 g/d." | 1.27 | Dietary choline effects on milk yield and duodenal choline flow in dairy cattle. ( Atkins, KB; Erdman, RA; Vandersall, JH, 1988) |
| "[3H]Choline uptake was highly inhibited by either 1." | 1.27 | Evidence of saturable uptake mechanisms at maternal and fetal sides of the perfused human placenta by rapid paired-tracer dilution: studies with calcium and choline. ( Abramovich, DR; Dacke, CG; Page, KR; Sweiry, JH; Yudilevich, DL, 1986) |
| "Glycerol and palmitate were relatively unimportant energy fuels in the perinatal lung." | 1.27 | Integrated substrate utilization by perinatal lung. ( Koniki, MV; Owens, CM; Patterson, CE; Rhoades, RA; Selig, WM, 1986) |
| "Dihydrotestosterone has previously been found to inhibit pulmonary surfactant production in vivo." | 1.27 | Dihydrotestosterone inhibits fibroblast-pneumonocyte factor-mediated synthesis of saturated phosphatidylcholine by fetal rat lung cells. ( Torday, JS, 1985) |
| "Choline status was assessed in control women, mothers and premature infants at birth and up to 14 days of life." | 1.27 | Measurement of free choline concentrations in maternal and neonatal blood by micropyrolysis gas chromatography. ( Farrell, PM; McMahon, KE, 1985) |
| " At the mid-range dosage tested (400 micrograms), dexamethasone depressed DNA (51%) appreciably more than total phosphatidylcholine (28%) and disaturated phosphatidylcholine (33%)." | 1.26 | Fetal lung disaturated phosphatidylcholine. Ostensible increase following exposure to dexamethasone. ( Funkhouser, JD; Hughes, ER, 1980) |
| "Choline did not increase lipid mobilization or piglet survival." | 1.26 | The influence of sow dietary lipids and choline on piglet survival, milk and carcass composition. ( McCampbell, HC; Seerley, RW; Snyder, RA, 1981) |
| "Tissue samples were taken from pregnant ewes and their 3-month fetuses 96 hours after intraruminal dosing of the ewes with tritiated choline." | 1.26 | Fate of labeled choline administered intraruminally to pregnant ewes given manganese-deficient or -supplemented rations. ( Hidiroglou, M; Kramer, JK; Williams, CJ, 1979) |
| "On the basis of curves illustrating the effects of dosage on experimental animals, it was shown that glucocorticoids inhibit as well as stimulate lecithin synthesis in the fetal lung." | 1.26 | [Experimental investigations in regard to the optimal stimulation of lecithin synthesis in the fetal lung via glucocorticoids (author's transl)]. ( Gerner, R; Halberstadt, E, 1976) |
| " Different dose-response curves were obtained for cytostasis and inhibition of [(3)H]-nucleoside incorporation, and changes in [(3)H]thymidine uptake were detected within 15 min of treatment with the inhibitors." | 1.25 | Rapid changes in nucleoside transport induced by growth inhibitors. Studies with neoplastic mast cells. ( Lingwood, CA; Thomas, DB, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 185 (27.82) | 18.7374 |
| 1990's | 56 (8.42) | 18.2507 |
| 2000's | 121 (18.20) | 29.6817 |
| 2010's | 191 (28.72) | 24.3611 |
| 2020's | 112 (16.84) | 2.80 |
| Authors | Studies |
|---|---|
| Grafe, EL | 2 |
| Fontaine, CJ | 1 |
| Thomas, JD | 12 |
| Christie, BR | 2 |
| Kwan, STC | 4 |
| Ricketts, DK | 1 |
| Presswood, BH | 1 |
| Smith, SM | 1 |
| Mooney, SM | 3 |
| Taesuwan, S | 2 |
| McDougall, MQ | 4 |
| Malysheva, OV | 18 |
| Bender, E | 2 |
| Nevins, JEH | 3 |
| Devapatla, S | 6 |
| Vidavalur, R | 2 |
| Caudill, MA | 36 |
| Klatt, KC | 8 |
| Robb, L | 1 |
| Joubert, G | 1 |
| Jordaan, EM | 1 |
| Ngounda, J | 1 |
| Walsh, CM | 1 |
| Derbyshire, E | 3 |
| Obeid, R | 7 |
| Schön, C | 2 |
| Mjaaseth, UN | 1 |
| Norris, JC | 1 |
| Aardema, NDJ | 1 |
| Bunnell, ML | 1 |
| Ward, RE | 1 |
| Hintze, KJ | 1 |
| Cho, CE | 1 |
| Liu, SX | 2 |
| Barks, AK | 1 |
| Lunos, S | 1 |
| Gewirtz, JC | 4 |
| Georgieff, MK | 13 |
| Tran, PV | 6 |
| Bahnfleth, CL | 1 |
| Strupp, BJ | 12 |
| Canfield, RL | 2 |
| McCabe, CF | 1 |
| LaBarre, JL | 1 |
| Domino, SE | 1 |
| Treadwell, MC | 1 |
| Baylin, A | 1 |
| Burant, CF | 1 |
| Dolinoy, DC | 2 |
| Padmanabhan, V | 1 |
| Goodrich, JM | 1 |
| Fang, Q | 1 |
| Liu, J | 5 |
| Chen, L | 2 |
| Chen, Q | 2 |
| Wang, Y | 8 |
| Li, Z | 3 |
| Fu, W | 2 |
| Liu, Y | 4 |
| Irvine, N | 2 |
| England-Mason, G | 2 |
| Field, CJ | 8 |
| Dewey, D | 3 |
| Aghajafari, F | 1 |
| Rees, G | 1 |
| Brough, L | 1 |
| Orsatti, GM | 1 |
| Lodge, A | 1 |
| Walker, S | 1 |
| Carugati, M | 1 |
| Goodlett, CR | 3 |
| Cudd, TA | 3 |
| Washburn, SE | 3 |
| Cochrane, KM | 1 |
| Williams, BA | 1 |
| Elango, R | 1 |
| Barr, SI | 1 |
| Karakochuk, CD | 1 |
| Ernst, AM | 3 |
| Gimbel, BA | 3 |
| de Water, E | 3 |
| Eckerle, JK | 6 |
| Radke, JP | 4 |
| Wozniak, JR | 6 |
| Fernandez-Osornio, LF | 1 |
| Gomez-Diaz, RA | 1 |
| Mondragon-Gonzalez, R | 1 |
| Gonzalez-Carranza, E | 1 |
| Diaz-Flores, M | 1 |
| Sharma, T | 1 |
| Hernández-Pineda, J | 1 |
| Maldonado-Rodriguez, R | 1 |
| Wacher, NH | 1 |
| Cruz, M | 1 |
| Valladares-Salgado, A | 1 |
| Carter, RC | 5 |
| Senekal, M | 2 |
| Duggan, CP | 4 |
| Dodge, NC | 5 |
| Meintjes, EM | 5 |
| Molteno, CD | 5 |
| Jacobson, JL | 5 |
| Jacobson, SW | 5 |
| Steane, SE | 3 |
| Kumar, V | 1 |
| Cuffe, JSM | 2 |
| Moritz, KM | 4 |
| Akison, LK | 3 |
| Curioni, CC | 1 |
| Mocellin, MC | 1 |
| Tavares, MDS | 1 |
| da Silva, ACF | 1 |
| de Velasco, PC | 1 |
| Ribas, SA | 1 |
| Lamarca, F | 1 |
| André, C | 1 |
| Loinard-González, AAP | 2 |
| Beckman, K | 1 |
| Bhawal, R | 1 |
| Anderson, E | 1 |
| Zhang, S | 1 |
| Jackson, KH | 2 |
| King, DJ | 4 |
| Dyer, RA | 4 |
| Brenna, JT | 3 |
| Wade, MMM | 1 |
| Hodson, CE | 1 |
| Christifano, DN | 1 |
| Chollet-Hinton, L | 1 |
| Hoyer, D | 1 |
| Schmidt, A | 1 |
| Gustafson, KM | 1 |
| Baker, JA | 2 |
| Breit, KR | 2 |
| Bodnar, TS | 2 |
| Weinberg, J | 2 |
| Jennings, L | 1 |
| Basiri, R | 1 |
| Zhang, J | 2 |
| Wang, Z | 3 |
| Dai, Y | 1 |
| Zhang, L | 2 |
| Guo, J | 1 |
| Lv, S | 1 |
| Qi, X | 1 |
| Lu, D | 1 |
| Liang, W | 1 |
| Cao, Y | 3 |
| Wu, C | 3 |
| Chang, X | 1 |
| Zhou, Z | 7 |
| Probst, Y | 1 |
| Sulistyoningrum, DC | 1 |
| Netting, MJ | 1 |
| Gould, JF | 1 |
| Wood, S | 1 |
| Makrides, M | 1 |
| Best, KP | 1 |
| Green, TJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Maternal Choline Intake on Maternal/Fetal Biomarkers of Choline Status[NCT01127022] | 82 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| Maternal Choline Supplementation and Its Impact on Docosahexaenoic Acid Supply in Human Pregnancy[NCT03194659] | 40 participants (Anticipated) | Interventional | 2017-10-05 | Recruiting | |||
| Prenatal Docosahexaenoic Acid (DHA) & Neurofunctional Development[NCT02709239] | 300 participants (Actual) | Interventional | 2016-06-01 | Completed | |||
| Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure[NCT01149538] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235] | 653 participants (Anticipated) | Interventional | 2021-02-12 | Recruiting | |||
| Phase 1 Study of the Effect of Maternal Nutritional Status on Placental Vascular Function, Fetal Growth and Intrauterine Growth Retardation.[NCT01778205] | 831 participants (Actual) | Observational | 2005-01-31 | Completed | |||
| Impact of Fish Oil or Probiotic Intake on Maternal Obesity and Molecular Biomarkers in the Placenta[NCT03215784] | 80 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | |||
| Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770] | 140 participants (Anticipated) | Interventional | 2019-10-10 | Active, not recruiting | |||
| Supply of Term and Preterm Neonates With Choline, Lipids and Vitamines[NCT02027584] | 414 participants (Actual) | Observational | 2008-11-30 | Completed | |||
| Nahrungsergänzung Mit Cholin- Und Docosahexaensäure Bei Sehr Unreifen Frühgeborenen[NCT02509728] | 24 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| [NCT02244684] | 368 participants (Actual) | Observational | 2010-09-30 | Completed | |||
| Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders[NCT01911299] | Phase 2 | 55 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Do Isreali Infants of Ethiopian Origin Mother Regurgitate More Than Other Infants?[NCT01185327] | 220 participants (Actual) | Observational | 2010-08-31 | Completed | |||
| The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD[NCT05200156] | 100 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | |||
| Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior[NCT05767385] | Phase 2/Phase 3 | 150 participants (Anticipated) | Interventional | 2021-12-17 | Recruiting | ||
| Supplemental Choline and Neurodevelopment in Humans[NCT00678925] | 150 participants (Actual) | Interventional | 2004-12-31 | Completed | |||
| Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)[NCT03269110] | 2,578 participants (Anticipated) | Observational | 2017-07-01 | Enrolling by invitation | |||
| Vitamin D Status and Metabolism in Pregnant and Nonpregnant Control Women Consuming Controlled and Equivalent Intakes of Vitamin D[NCT03051867] | 47 participants (Actual) | Observational | 2009-01-15 | Completed | |||
| Double-blind Trial of Phosphatidylcholine During Pregnancy and Infant Serum Choline Levels[NCT00332124] | Phase 1 | 351 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Defining Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency[NCT02691611] | 39 participants (Actual) | Observational | 2015-12-31 | Active, not recruiting | |||
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Elicited Imitation (EI) paradigm (P.J. Bauer, 1989, Dev. Psychology) was used to measure memory in the participants at baseline, 6 months, and 9 months. The measures were items recalled after a delay (delayed items) and pairs of items recalled after a delay (delayed pairs). The sample was split by age in the analysis (young vs. old) as reflected in the outcome data. Outcome data measures included here are the slopes of the regression lines reflecting change over the three timepoints, controlling for immediate memory performance on the EI task.The slopes are given, as opposed to the raw scores, because these were the values used in the growth curve analyses. Details of these analyses are included in Wozniak et al. (2015) AJCN, doi:10.3945/ajcn.114.099168. NOTE that the means presented below represent the simple slopes that estimate the change in task performance (% of items correct) per 6-month unit of time. To estimate change in task performance over 9 months, multiply by 1.5. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Slope (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Delayed-Items-Young | Delayed-Items-Old | Delayed-Pairs-Young | Delayed-Pairs-Old | Immed-Items-Young | Immed-Items-Old | Immed-Pairs-Young | Immed-Pairs-Old | |
| Choline Bitartrate | 14.24 | -.71 | 18.97 | 2.69 | 8.48 | 2.59 | 8.75 | 11.46 |
| Placebo | 4.43 | 4.23 | 10.39 | 7.79 | 13.72 | 3.89 | 20.01 | 5.50 |
Evoked Response Potential - negative component latency data are included. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Milliseconds (Mean) | ||
|---|---|---|---|
| Frontal Neg Component Latency at baseline | Frontal Neg Component at 6 months | Frontal Neg Component at 9 months | |
| Choline Bitartrate | 2.23 | 32.45 | -4.00 |
| Placebo | 5.35 | -4.28 | -3.03 |
Evoked response potentials were measured for the memory task. Frontal positive slow-wave potential negative component amplitude data are included. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Mircovolts (Mean) | |||||
|---|---|---|---|---|---|---|
| Frontal Positive Slow Wave (PSW) - Baseline | Frontal Positive Slow Wave (PSW) - 6 months | Frontal Positive Slow Wave (PSW) - 9 months | Frontal Neg Component Amplitude - Baseline | Frontal Neg Component Amplitude - 6 months | Frontal Neg Component Amplitude - 9 months | |
| Choline Bitartrate | -2.05 | -1.04 | -0.26 | -2.53 | 1.22 | 0.35 |
| Placebo | 0.57 | -1.03 | -1.41 | 0.62 | -0.84 | -1.37 |
The Mullen Scales of Early Learning is a measure of global cognitive development and is a primary outcome measure. The Early Learning Composite is the total score for this measure. It is a scaled score with a mean of 100 and a standard deviation of 15 (higher scores indicate better global cognitive status; average range is 85-115; Impaired range is 70 or below; full range is typically 50 - 150, although minimum and maximum scores are dependent on age). See the Mullen Scales reference manual for more psychometric details. (NCT01149538)
Timeframe: Baseline and 9 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 9-month follow-up | |
| Choline Bitartrate | 83.2 | 87.1 |
| Placebo | 84.3 | 89.6 |
Side effects of choline bitartrate will be monitored by the study physician and the P.I. with physical examinations and telephone contact. (NCT01149538)
Timeframe: Baseline, 6 months, & 9 months
| Intervention | participants (Number) | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline energy level problems | 6 month energy level problems | 9 months energy level problems | Baseline pain | 6 month pain | 9 month pain | Baseline skin problems | 6 month skin problems | 9 month skin problems | Baseline Ear Nose Throat problems | 6 month Ear Nose Throat problems | 9 month Ear Nose Throat problems | Baseline headaches/dizziness | 6 month headaches/dizziness | 9 month headaches/dizziness | Baseline vision problems | 6 month vision problems | 9 month vision problems | Baseline cardiovascular | 6 month cardiovascular | 9 month cardiovascular | Baseline respiratory problems | 6 month respiratory problems | 9 month respiratory problems | Baseline gastrointestinal problems | 6 month gastrointestinal problems | 9 month gastrointestinal problems | Baseline genitourinary problems | 6 month genitourinary problems | 9 month genitourinary problems | Baseline musculoskeletal problems | 6 month musculoskeletal problems | 9 month musculoskeletal problems | 6 month neurologic/psychiatric problems | 9 month neurologic/psychiatric problems | Baseline neurologic/psychiatric problems | Baseline allergic problems | 6 month allergic problems | 9 month allergic problems | |
| Choline Bitartrate | 8 | 8 | 8 | 3 | 3 | 3 | 6 | 6 | 6 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 0 | 0 | 1 | 1 | 1 | 6 | 6 | 6 | 18 | 18 | 18 | 4 | 4 | 4 | 0 | 0 | 0 | 11 | 11 | 11 | 2 | 0 | 0 |
| Placebo | 10 | 9 | 9 | 4 | 4 | 4 | 6 | 5 | 5 | 0 | 0 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 6 | 6 | 6 | 14 | 11 | 11 | 9 | 8 | 8 | 1 | 1 | 1 | 9 | 9 | 9 | 3 | 3 | 3 |
66 reviews available for choline and Pregnancy
| Article | Year |
|---|---|
Habitual Choline Intakes across the Childbearing Years: A Review.
Topics: Adolescent; Adult; Choline; Dietary Supplements; Eating; Female; Humans; Lactation; Maternal Nutriti | 2021 |
Prenatal Folate and Choline Levels and Brain and Cognitive Development in Children: A Critical Narrative Review.
Topics: Animals; Brain; Child; Child Development; Child, Preschool; Choline; Cognition; Female; Fetal Develo | 2022 |
Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review.
Topics: Adult; Anemia; Choline; Diabetes Mellitus, Type 1; Dietary Supplements; Fatty Acids, Omega-3; Female | 2022 |
Pregnancy-induced alterations of 1-carbon metabolism and significance for maternal nutrition requirements.
Topics: Carbon; Choline; Female; Humans; Nutritional Requirements; Placenta; Pregnancy; Vitamin B Complex | 2022 |
Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder.
Topics: Child; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Preg | 2022 |
Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials.
Topics: Acetylcysteine; Brain Injuries; Cerebral Palsy; Child; Choline; Docosahexaenoic Acids; Female; Fetal | 2022 |
Amino Acids, B Vitamins, and Choline May Independently and Collaboratively Influence the Incidence and Core Symptoms of Autism Spectrum Disorder.
Topics: Amino Acids; Autism Spectrum Disorder; Child; Choline; Dietary Supplements; Female; Humans; Incidenc | 2022 |
Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Topics: Brain; Child; Child Development; Choline; Diet; Dietary Supplements; Female; Humans; Infant, Newborn | 2022 |
High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Carbon; Choline; Diabet | 2022 |
Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants.
Topics: Amino Acids; Animals; Antioxidants; Choline; Dietary Supplements; Female; Lysine; Methionine; Pregna | 2022 |
The role of maternal choline, folate and one-carbon metabolism in mediating the impact of prenatal alcohol exposure on placental and fetal development.
Topics: Carbon; Choline; Female; Fetal Development; Folic Acid; Humans; Maternal-Fetal Exchange; Micronutrie | 2023 |
Maternal choline supplementation during pregnancy to promote mental health in offspring.
Topics: Brain; Choline; Dietary Supplements; Female; Fetal Development; Humans; Mental Health; Pregnancy; Pr | 2023 |
[The influence of maternal choline supplementation on fetal brain development and the risk of psychotic symptoms].
Topics: Animals; Brain; Choline; Dietary Supplements; Family; Female; Humans; Pregnancy; Psychotic Disorders | 2023 |
Nutrient Supplementation during the Prenatal Period in Substance-Using Mothers: A Narrative Review of the Effects on Offspring Development.
Topics: Animals; Choline; Dietary Supplements; Ethanol; Female; Humans; Mothers; Nicotine; Pregnancy; Prenat | 2023 |
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi | 2020 |
Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days.
Topics: Age Factors; Animals; Brain; Choline; Cognition; Dietary Supplements; Female; Humans; Infant; Infant | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
[Importance of choline in cognitive function].
Topics: Adult; Aged; Aged, 80 and over; Choline; Cognition; Dementia; Diet; Female; Humans; Middle Aged; Neu | 2021 |
Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum.
Topics: Brain; Child; Choline; Dietary Supplements; Female; Fetal Development; Folic Acid; Humans; Micronutr | 2022 |
Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development.
Topics: Animals; Brain; Child Development; Choline; COVID-19; Developmental Disabilities; Dietary Supplement | 2021 |
Choline and docosahexaenoic acid during the first 1000 days and children's health and development in low- and middle-income countries.
Topics: Animals; Child; Child Health; Child, Preschool; Choline; Developing Countries; Docosahexaenoic Acids | 2022 |
[Research advances in the association between maternal intake of methyl donor nutrients during pregnancy and DNA methylation in offspring].
Topics: Betaine; Choline; DNA Methylation; Female; Folic Acid; Humans; Maternal Nutritional Physiological Ph | 2017 |
A crucial role for maternal dietary methyl donor intake in epigenetic programming and fetal growth outcomes.
Topics: Animals; Birth Weight; Carbon; Choline; Diet; DNA Methylation; Epigenesis, Genetic; Epigenomics; Fem | 2018 |
Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Choline; Clinical Trials as Topic; Cognition; Cognitive | 2018 |
Choline and choline-related nutrients in regular and preterm infant growth.
Topics: Betaine; Child Development; Choline; Choline Deficiency; Female; Humans; Infant; Infant, Low Birth W | 2019 |
Folate and choline absorption and uptake: Their role in fetal development.
Topics: Animals; Biological Transport, Active; Choline; Eating; Female; Fetal Development; Folic Acid; Human | 2019 |
Choline: The Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists.
Topics: Choline; Diet; Female; Folic Acid; Humans; Maternal Nutritional Physiological Phenomena; Nutritional | 2020 |
The role of folic acid fortification in neural tube defects: a review.
Topics: Biological Availability; Choline; Edible Grain; Female; Folic Acid; Folic Acid Antagonists; Food, Fo | 2013 |
Prenatal treatment of Down syndrome: a reality?
Topics: Animals; Animals, Newborn; Apigenin; Catechin; Choline; Disease Models, Animal; Down Syndrome; Dyrk | 2014 |
Maternal choline supplementation: a nutritional approach for improving offspring health?
Topics: Animals; Choline; Dietary Supplements; Epigenesis, Genetic; Female; Fetal Development; Humans; Mater | 2014 |
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas | 2014 |
Nutrition implications for fetal alcohol spectrum disorder.
Topics: Alcohol Drinking; Animals; Antioxidants; Brain; Choline; Dietary Supplements; Disease Models, Animal | 2014 |
[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy].
Topics: Choline; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Humans; Maternal Nutritiona | 2015 |
The role of rumen-protected choline in hepatic function and performance of transition dairy cows.
Topics: Animals; Cattle; Choline; Female; Lactation; Liver; Pregnancy; Rumen | 2016 |
Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's diet.
Topics: Adult; Choline; Diet; Dietary Supplements; Docosahexaenoic Acids; Female; Folic Acid; Humans; Infant | 2009 |
Importance of methyl donors during reproduction.
Topics: Brain; Choline; Female; Fetal Development; Folic Acid; Food, Fortified; Humans; Infant, Newborn; Met | 2009 |
The addition of choline to parenteral nutrition.
Topics: Aged; Burns; Child; Choline; Choline Deficiency; Female; Humans; Lactation; Liver Cirrhosis; Liver D | 2009 |
Choline: an essential nutrient for public health.
Topics: Adolescent; Adult; Aged; Animals; Breast Neoplasms; Child; Child, Preschool; Choline; Choline Defici | 2009 |
[Magnetic resonance spectroscopy for cerebral imaging].
Topics: Apoptosis; Aspartic Acid; Asphyxia Neonatorum; Biomarkers, Tumor; Brain; Brain Diseases; Brain Disea | 2010 |
Pre- and postnatal health: evidence of increased choline needs.
Topics: Choline; Female; Fetal Development; Humans; Infant Nutritional Physiological Phenomena; Infant, Newb | 2010 |
What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.
Topics: Animals; Choline; Diet; Epigenesis, Genetic; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Huma | 2011 |
Nutritional genomics: defining the dietary requirement and effects of choline.
Topics: Animals; Choline; Female; Folic Acid; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); | 2011 |
The supply of choline is important for fetal progenitor cells.
Topics: Animals; Brain; Child; Choline; Choline Deficiency; Developmental Biology; Diet; DNA Methylation; Em | 2011 |
The impact of nutrition on differential methylated regions of the genome.
Topics: Adult; Amino Acids; Animals; Choline; DNA Methylation; Female; Folic Acid; Food; Genistein; Genome, | 2011 |
Choline nutrition programs brain development via DNA and histone methylation.
Topics: Animals; Brain; Choline; Choline Deficiency; DNA Methylation; Female; Histones; Humans; Nutritional | 2012 |
Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.
Topics: Adult; Brain; Child; Child Development; Choline; Diet; Epigenomics; Female; Fetal Development; Healt | 2012 |
The nutrigenetics and nutrigenomics of the dietary requirement for choline.
Topics: Adolescent; Adult; Child; Child, Preschool; Choline; Female; Humans; Infant; Infant, Newborn; Male; | 2012 |
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan.
Topics: Aging; Animals; Attention; Behavior, Animal; Choline; Cognition; Dietary Supplements; Embryonic and | 2003 |
An overview of oocyte cryopreservation.
Topics: Animals; Cattle; Cell Survival; Choline; Cryopreservation; Cryoprotective Agents; Female; Humans; Mi | 2004 |
Nutritional importance of choline for brain development.
Topics: Animals; Apoptosis; Brain; Cell Division; Cell Movement; Cell Proliferation; Choline; Female; Folic | 2004 |
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring.
Topics: Animals; Behavior, Animal; Brain; Cell Size; Choline; Choline Deficiency; Cognition; Critical Period | 2006 |
Perinatal choline influences brain structure and function.
Topics: Brain; Choline; Female; Fetal Development; Folic Acid; Humans; Infant, Newborn; Lactation; Male; Met | 2006 |
Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet.
Topics: Amino Acids, Sulfur; Animals; Choline; Diet; DNA Methylation; Drug Interactions; Endocrine System; F | 2006 |
Choline: critical role during fetal development and dietary requirements in adults.
Topics: Brain; Choline; Choline Deficiency; Female; Fetal Development; Humans; Male; Nutritional Requirement | 2006 |
The fetal origins of memory: the role of dietary choline in optimal brain development.
Topics: Brain; Choline; Diet; Female; Folic Acid; Humans; Infant; Methionine; Nootropic Agents; Pregnancy; S | 2006 |
Nutritional and management strategies for the prevention of fatty liver in dairy cattle.
Topics: Animal Nutritional Physiological Phenomena; Animals; Cattle; Cattle Diseases; Choline; Dietary Suppl | 2008 |
Dietary choline: biochemistry, physiology, and pharmacology.
Topics: Animals; Choline; Digestion; Female; Fetus; Food Analysis; Humans; Hypertension; Infant, Newborn; In | 1981 |
Choline: essential for brain development and function.
Topics: Acetylcholine; Animals; Apoptosis; Brain; Choline; Choline Deficiency; Female; Humans; Infant, Newbo | 1997 |
Choline: needed for normal development of memory.
Topics: Animals; Brain; Choline; Choline Deficiency; Diet; Eggs; Female; Humans; Infant, Newborn; Lactation; | 2000 |
Choline acetyltransferase: a review with special reference to its cellular and subcellular localization.
Topics: Acetyl Coenzyme A; Acetylcholine; Action Potentials; Animals; Axonal Transport; Brain; Cats; Chemica | 1977 |
Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.
Topics: Animals; Animals, Newborn; Autoantibodies; B-Lymphocytes; Binding Sites, Antibody; Choline; Female; | 1977 |
Choline acetyltransferase.
Topics: Acetylcholine; Acyl Coenzyme A; Animals; Binding Sites; Brain; Choline; Choline O-Acetyltransferase; | 1977 |
Cholinergic systems in non-nervous tissues.
Topics: Acetylcholine; Animals; Bacterial Physiological Phenomena; Blood Cells; Cell Physiological Phenomena | 1978 |
Developmental aspects of lung lipids.
Topics: Androgens; Animals; Choline; Embryonic and Fetal Development; Endocrine Glands; Fatty Acids; Female; | 1985 |
Lipotropes and fetal growth.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Choline; Cystine; Deficiency | 1971 |
Progress in swine nutrition for the veterinarian.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Biotin; Calcium; Choline; Dietary | 1973 |
51 trials available for choline and Pregnancy
| Article | Year |
|---|---|
Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial.
Topics: Adaptation, Physiological; Adult; Case-Control Studies; Choline; Dietary Supplements; Female; Fetal | 2021 |
Prenatal choline supplementation improves child sustained attention: A 7-year follow-up of a randomized controlled feeding trial.
Topics: Animals; Attention; Child; Child Development; Child, Preschool; Choline; Dietary Supplements; Double | 2022 |
Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid (DHA) status among pregnant participants consuming supplemental DHA: a randomized controlled trial.
Topics: Biomarkers; Choline; Dietary Supplements; Docosahexaenoic Acids; Female; Humans; Infant, Newborn; Ph | 2022 |
Genetic Variants in One-Carbon Metabolism and Their Effects on DHA Biomarkers in Pregnant Women: A Post-Hoc Analysis.
Topics: Biomarkers; Carbon; Choline; Docosahexaenoic Acids; Fatty Acids; Female; Humans; Infant, Newborn; Ph | 2022 |
Estimated Choline Intakes and Dietary Sources of Choline in Pregnant Australian Women.
Topics: Australia; Choline; Diet; Female; Humans; Pregnancy; Pregnant Women; Vegetables | 2022 |
Effects of prenatal dietary rumen-protected choline supplementation during late gestation on calf growth, metabolism, and vaccine response.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Antioxidants; Cattle; Choline; Diet; Dietary Suppl | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Dynamic Metabolic Signatures of Choline and Carnitine across Healthy Pregnancy and in Cord Blood: Association with Maternal Dietary Protein.
Topics: Carnitine; Choline; Dietary Proteins; Dietary Supplements; Female; Fetal Blood; Humans; Pregnancy | 2023 |
Rumen-protected choline and methionine during the periparturient period affect choline metabolites, amino acids, and hepatic expression of genes associated with one-carbon and lipid metabolism.
Topics: Amino Acids; Animals; Betaine; Cattle; Choline; Diet; Dietary Supplements; Female; Lactation; Lecith | 2023 |
In utero choline exposure alters growth, metabolism, feed efficiency, and carcass characteristics of Holstein × Angus cattle from weaning to slaughter.
Topics: Animal Feed; Animals; Cattle; Choline; Diet; Dietary Supplements; Eating; Female; Male; Pregnancy; W | 2023 |
Increasing the prepartum dose of rumen-protected choline: Effects of maternal choline supplementation on growth, feed efficiency, and metabolism in Holstein and Holstein × Angus calves.
Topics: Animal Feed; Animals; Body Weight; Cattle; Choline; Diet; Dietary Supplements; Female; Lactation; Ma | 2023 |
Micronutrient Gaps and Supplement Use in a Diverse Cohort of Pregnant Women.
Topics: Choline; Cross-Sectional Studies; Diet; Dietary Supplements; Female; Folic Acid; Humans; Iron; Magne | 2023 |
Longitudinal changes in choline concentration and associated factors in human breast milk.
Topics: Choline; Female; Glycerylphosphorylcholine; Humans; Infant; Lactation; Milk, Human; Pregnancy; Water | 2023 |
Restricted maternal nutrition and supplementation of propylene glycol, monensin sodium and rumen-protected choline chloride during late pregnancy does not affect muscle fibre characteristics of offspring.
Topics: Animals; Choline; Dietary Supplements; Female; Male; Monensin; Muscle Fibers, Skeletal; Pregnancy; P | 2023 |
Choline and Betaine Levels in Plasma Mirror Choline Intake in Very Preterm Infants.
Topics: Betaine; Choline; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Dis | 2023 |
Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy.
Topics: Adult; Animals; Betaine-Homocysteine S-Methyltransferase; Choline; Choline Dehydrogenase; Dietary Su | 2019 |
Reproductive state and choline intake influence enrichment of plasma lysophosphatidylcholine-DHA: a
Topics: Adult; Choline; Deuterium; Dietary Supplements; Docosahexaenoic Acids; Female; Genotype; Humans; Lac | 2019 |
Effects of rumen-protected choline on the inflammatory and metabolic status and health of dairy cows during the transition period.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Choline; Diet; Dietary Supplements; Female; | 2020 |
Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
Topics: Child, Preschool; Choline; Cognition; Double-Blind Method; Female; Fetal Alcohol Spectrum Disorders; | 2020 |
Production responses to rumen-protected choline and methionine supplemented during the periparturient period differ for primi- and multiparous cows.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Choline; Diet; Dietary Sup | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
Topics: Adult; Brain; Choline; Dietary Supplements; Double-Blind Method; Ethanol; Female; Fetal Alcohol Spec | 2021 |
Maternal methyl donor supplementation during gestation counteracts bisphenol A-induced oxidative stress in sows and offspring.
Topics: Actins; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Benzhydryl Compounds; Beta | 2018 |
Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study.
Topics: Adult; Child Development; Choline; Dietary Supplements; Double-Blind Method; Female; Humans; Infant, | 2018 |
Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Alcohol Drinking; Choline; Dietary Supplements; Double-Blind Method; Feasibility Studies; Female; Fe | 2018 |
Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Adult; Alcohol Drinking; Birth Weight; Blinking; Choline; Cognition; Dietary Supplements; Double-Bli | 2018 |
Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Depressants; Child; Child, Preschool | 2019 |
Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester.
Topics: Choline; Dietary Supplements; Docosahexaenoic Acids; Erythrocytes; Female; Humans; Lipid Metabolism; | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys | 2013 |
Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.
Topics: Alcohol Drinking; Child, Preschool; Choline; Dietary Supplements; Double-Blind Method; Female; Fetal | 2013 |
[Influence of feeding rumen-protected choline to transition dairy cows. Part 2: Health and reproduction].
Topics: Animals; Cattle; Cattle Diseases; Choline; Dairying; Endometriosis; Female; Lactation; Lameness, Ani | 2014 |
Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
Topics: Adult; Biomarkers; Biotin; Carbon-Carbon Ligases; Carnitine; Choline; Chromatography, Liquid; Diet; | 2014 |
Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes.
Topics: Adult; Biomarkers; Breast Feeding; Choline; Dietary Supplements; Dose-Response Relationship, Drug; D | 2015 |
(1)H MRS: a potential biomarker of in utero placental function.
Topics: Adult; Algorithms; Amino Acids; Body Mass Index; Choline; Female; Fetal Growth Retardation; Gastrosc | 2015 |
The effect of dietary supplementation with rumen-protected methionine alone or in combination with rumen-protected choline and betaine on sheep milk and antioxidant capacity.
Topics: Animal Feed; Animals; Antioxidants; Betaine; Choline; Diet; Dietary Supplements; Fatty Acids; Female | 2017 |
Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.
Topics: Child; Child, Preschool; Choline; Cognition; Dietary Supplements; Dose-Response Relationship, Drug; | 2016 |
Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status.
Topics: Amino Acids; Amino Acids, Essential; Animal Feed; Animal Nutritional Physiological Phenomena; Animal | 2016 |
Effect of rumen-protected choline and methionine on physiological and metabolic disorders and reproductive indices of dairy cows.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Cattle Diseases; Choline; | 2010 |
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.
Topics: Adult; Betaine; Choline; Diet; Diet Records; Dietary Supplements; Female; Genotype; Humans; Lactatio | 2010 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc | 2012 |
Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.
Topics: Adult; Choline; Corticotropin-Releasing Hormone; DNA Methylation; Epigenesis, Genetic; Female; Fetal | 2012 |
Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.
Topics: Adult; Choline; Corticotropin-Releasing Hormone; DNA Methylation; Epigenesis, Genetic; Female; Fetal | 2012 |
Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.
Topics: Adult; Choline; Corticotropin-Releasing Hormone; DNA Methylation; Epigenesis, Genetic; Female; Fetal | 2012 |
Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.
Topics: Adult; Choline; Corticotropin-Releasing Hormone; DNA Methylation; Epigenesis, Genetic; Female; Fetal | 2012 |
Pregnancy induces transcriptional activation of the peripheral innate immune system and increases oxidative DNA damage among healthy third trimester pregnant women.
Topics: Adult; Case-Control Studies; Choline; Cluster Analysis; Diet; DNA Damage; Epigenomics; Female; Gene | 2012 |
A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1).
Topics: Acetylcholine; Adult; Angiogenesis Inhibitors; Biomarkers; Cells, Cultured; Choline; Dietary Supplem | 2013 |
Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Attention; Brain; Child, Preschool; Choline; DNA Mutational | 2013 |
Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Choline; Embryonic and Fetal Development; Female; Gestational | 2002 |
Lipid metabolite profiles and milk production for Holstein and Jersey cows fed rumen-protected choline during the periparturient period.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cholesterol; Choline; Diet; Fatty Acids, None | 2006 |
Prognostic value of 1H-MRS in neonatal encephalopathy.
Topics: Apgar Score; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Choline; Creatine; Creatinine; Femal | 2006 |
Effects of rumen-protected choline and monensin on milk production and metabolism of periparturient dairy cows.
Topics: Animal Feed; Animals; Cattle; Cholesterol; Choline; Delayed-Action Preparations; Diet; Eating; Energ | 2006 |
Supplemental choline for prevention and alleviation of fatty liver in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Choline; Dairying; Dietary S | 2007 |
Effects of rumen-protected choline supplementation in periparturient dairy goats.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline; Dairying; Diet; Dietary S | 2007 |
[Essaven treatment of varicose veins in pregnancy].
Topics: Adult; Bandages; Choline; Edema; Female; Humans; Middle Aged; Phytotherapy; Plants, Medicinal; Pregn | 1969 |
549 other studies available for choline and Pregnancy
| Article | Year |
|---|---|
Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus.
Topics: Animals; Central Nervous System Depressants; Choline; Dentate Gyrus; Disease Models, Animal; Ethanol | 2021 |
Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol-exposed fetal organs.
Topics: Animals; Animals, Newborn; Choline; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders | 2021 |
Choline supplementation as an intervention for fetal alcohol spectrum disorders: A commentary.
Topics: Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Pregnancy | 2021 |
Choline intake and associations with egg and dairy consumption among pregnant women attending a high-risk antenatal clinic in South Africa: the NuEMI study.
Topics: Adult; Choline; Cross-Sectional Studies; Dairy Products; Diet Surveys; Eggs; Female; Humans; Nutriti | 2021 |
Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Choline; Diet; Female; Folic | 2021 |
Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate
Topics: Animals; Brain-Derived Neurotrophic Factor; Choline; Dietary Supplements; DNA-Binding Proteins; Epig | 2021 |
Maternal and neonatal one-carbon metabolites and the epigenome-wide infant response.
Topics: Adult; Betaine; Carbon; Choline; Cohort Studies; DNA Methylation; Epigenome; Female; Fetal Blood; Hi | 2022 |
Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis.
Topics: Animals; Aspartic Acid; Choline; Creatine; Dietary Supplements; Female; Fetal Growth Retardation; Gl | 2022 |
The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent.
Topics: Animals; Choline; Dietary Supplements; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disord | 2022 |
Micronutrients of the one-carbon metabolism cycle are altered in mothers and neonates by gestational diabetes and are associated with weight, height and head circumference at birth.
Topics: Betaine; Birth Weight; Carbon; Choline; Diabetes, Gestational; Female; Folic Acid; Glycine; Humans; | 2022 |
Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort.
Topics: Alcohol Drinking; Animals; Birth Cohort; Child; Choline; Diet; Ethanol; Female; Fetal Alcohol Spectr | 2022 |
Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure.
Topics: Animals; Carbon; Choline; Dietary Supplements; Ethanol; Female; Humans; Placenta; Pregnancy; Prenata | 2022 |
Postnatal Choline Supplementation Rescues Deficits in Synaptic Plasticity Following Prenatal Ethanol Exposure.
Topics: Animals; Choline; Dietary Supplements; Ethanol; Female; Humans; Male; Neuronal Plasticity; Pregnancy | 2022 |
Intake of eggs, choline, lutein, zeaxanthin, and DHA during pregnancy and their relationship to fetal neurodevelopment.
Topics: Choline; Diet; Female; Humans; Lutein; Pregnancy; Prenatal Care; Zeaxanthins | 2023 |
Choline Supplementation Modifies the Effects of Developmental Alcohol Exposure on Immune Responses in Adult Rats.
Topics: Animals; Animals, Newborn; Choline; Cytokines; Dietary Supplements; Ethanol; Female; Hippocampus; Im | 2022 |
Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes.
Topics: Acetylcarnitine; Bayes Theorem; Betaine; Choline; Cohort Studies; Estradiol; Female; Humans; Leptin; | 2022 |
Characterization of Choline Nutriture among Adults and Children with Phenylketonuria.
Topics: Adult; Child; Choline; Female; Folic Acid; Humans; Methionine; Nutrition Surveys; Phenylalanine; Phe | 2022 |
Effects of maternal choline supplementation on performance and immunity of progeny from birth to weaning.
Topics: Animal Feed; Animals; Animals, Newborn; Cattle; Choline; Colostrum; Diet; Dietary Supplements; Femal | 2022 |
Choline alleviated perinatal fluoride exposure-induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice.
Topics: Animals; Choline; Female; Fluorides; Hippocampus; Memory Disorders; Mice; Pregnancy | 2023 |
One-carbon metabolism-related nutrients intake is associated with lower risk of preeclampsia in pregnant women: a matched case-control study.
Topics: Case-Control Studies; Choline; Eating; Female; Folic Acid; Humans; Methionine; Nutrients; Pre-Eclamp | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Inadequate Choline Intake in Pregnant Women in Germany.
Topics: Adult; Choline; Female; Germany; Humans; Middle Aged; Pregnancy; Pregnant Women; Vegans; Vegetarians | 2022 |
Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood.
Topics: Child, Preschool; Choline; DNA Methylation; Female; Folic Acid; Humans; Infant, Newborn; Micronutrie | 2023 |
Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood.
Topics: Child, Preschool; Choline; DNA Methylation; Female; Folic Acid; Humans; Infant, Newborn; Micronutrie | 2023 |
Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood.
Topics: Child, Preschool; Choline; DNA Methylation; Female; Folic Acid; Humans; Infant, Newborn; Micronutrie | 2023 |
Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood.
Topics: Child, Preschool; Choline; DNA Methylation; Female; Folic Acid; Humans; Infant, Newborn; Micronutrie | 2023 |
Choline Supplementation Alters Hippocampal Cytokine Levels in Adolescence and Adulthood in an Animal Model of Fetal Alcohol Spectrum Disorders.
Topics: Adolescent; Animals; Animals, Newborn; Choline; Cytokines; Dietary Supplements; Ethanol; Female; Fet | 2023 |
Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes.
Topics: Animals; Choline; Diet, High-Fat; Dietary Supplements; Female; Humans; Lipidomics; Liver; Male; Mate | 2023 |
Associations between maternal folate status and choline intake during pregnancy and neurodevelopment at 3-4 years of age in the Alberta Pregnancy Outcomes and Nutrition (APrON) study.
Topics: Alberta; Animals; Child; Child, Preschool; Choline; Dietary Supplements; Female; Folic Acid; Humans; | 2023 |
Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome.
Topics: Animals; Animals, Newborn; Choline; Female; Hippocampus; Humans; Iron; Iron Deficiencies; Male; Preg | 2023 |
Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring.
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Inflammation; Ischemic Stroke; Lactation; | 2023 |
Differential Early Mechanistic Frontal Lobe Responses to Choline Chloride and Soy Isoflavones in an Experimental Model of Fetal Alcohol Spectrum Disorder.
Topics: Animals; Choline; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Frontal Lobe; Humans; Insulin; | 2023 |
Effect of source and amount of rumen-protected choline on hepatic metabolism during induction of fatty liver in dairy cows.
Topics: Animals; Cattle; Cattle Diseases; Cholesterol; Choline; Diet; Dietary Supplements; Fatty Acids; Fatt | 2023 |
The distribution of dietary choline intake and serum choline levels in Australian women during pregnancy and associated early life factors.
Topics: Australia; Choline; Diet; Eating; Female; Humans; Infant; Pregnancy; Pregnant Women | 2023 |
Maternal dietary intake among alcohol-exposed pregnancies is linked to early infant physical outcomes in South Africa.
Topics: Calcium; Choline; Diet; Eating; Ethanol; Fatty Acids; Female; Fetal Alcohol Spectrum Disorders; Foli | 2023 |
Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows.
Topics: Animals; Cattle; Choline; Diet; Dietary Supplements; Fatty Liver; Female; Glycogen; Lactation; Liver | 2023 |
Impact of maternal dietary folic acid or choline dietary deficiencies on vascular function in young and middle-aged female mouse offspring after ischemic stroke.
Topics: Animals; Carbon; Choline; Diet; Female; Folic Acid; Humans; Ischemic Stroke; Maternal Nutritional Ph | 2023 |
Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease.
Topics: Brain; Choline; Female; Fetus; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Magnetic Reso | 2023 |
[Association between maternal plasma one-carbon biomarkers during pregnancy and fetal growth in twin pregnancies].
Topics: Adult; Betaine; Biomarkers; Birth Weight; Choline; Cohort Studies; Female; Fetal Development; Fetal | 2023 |
Choline: Exploring the Growing Science on Its Benefits for Moms and Babies.
Topics: Animals; Choline; Diet; Dietary Supplements; Female; Fetus; Health Promotion; Humans; Maternal Nutri | 2019 |
Hepatic 1-carbon metabolism enzyme activity, intermediate metabolites, and growth in neonatal Holstein dairy calves are altered by maternal supply of methionine during late pregnancy.
Topics: Animals; Animals, Newborn; Betaine; Betaine-Homocysteine S-Methyltransferase; Biomarkers; Carbon; Ca | 2019 |
Using Differential Threshold Effects of Individual and Combined Periconceptional Methyl Donor Status on Maternal Genomic LINE-1 and Imprinted H19 DNA Methylation to Predict Birth Weight Variance in the Taiwan Pregnancy-Newborn Epigenetics (TPNE) Cohort St
Topics: Adult; Betaine; Birth Weight; Choline; Cohort Studies; Differential Threshold; DNA; DNA Methylation; | 2020 |
Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development.
Topics: Brain; C-Reactive Protein; Choline; Female; Fetal Development; Fetus; Gestational Age; Humans; Infan | 2021 |
Prenatal Choline Supplementation during High-Fat Feeding Improves Long-Term Blood Glucose Control in Male Mouse Offspring.
Topics: Adiposity; Animals; Blood Glucose; Choline; Diet, High-Fat; Dietary Supplements; Female; Glucose Int | 2020 |
Rescue of ethanol-induced FASD-like phenotypes via prenatal co-administration of choline.
Topics: Animals; Animals, Newborn; Anxiety; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol Spe | 2020 |
Choline ameliorates ethanol induced alterations in tyrosine phosphorylation and distribution in detergent-resistant membrane microdomains of L1 cell adhesion molecule in vivo.
Topics: Animals; Choline; Detergents; Ethanol; Female; Membrane Microdomains; Neural Cell Adhesion Molecule | 2020 |
Urine metabolome alterations in malnutrition and the impact of glycerol or rumen-protected choline chloride supplementation in advanced pregnant ewes.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline; Diet; Dietary Supplements | 2020 |
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate C | 2020 |
Maternal Choline Intake Programs Hypothalamic Energy Regulation and Later-Life Phenotype of Male Wistar Rat Offspring.
Topics: Animals; Body Weight; Choline; Eating; Energy Metabolism; Female; Hypothalamus; Lactation; Male; Neu | 2020 |
Vaginal metabolome: towards a minimally invasive diagnosis of microbial invasion of the amniotic cavity in women with preterm labor.
Topics: Acetylcholine; Adult; Amniocentesis; Bacterial Infections; Case-Control Studies; Choline; Chorioamni | 2020 |
Feeding Buttermilk-Derived Choline Forms During Gestation and Lactation Modulates Ex Vivo T-Cell Response in Rat Dams.
Topics: Animal Feed; Animals; Buttermilk; Choline; Concanavalin A; Diet; Female; Maternal Nutritional Physio | 2020 |
Maternal choline and respiratory coronavirus effects on fetal brain development.
Topics: Adult; Attention; Betacoronavirus; Brain; Child Development; Choline; Coronavirus Infections; COVID- | 2020 |
Non-invasive measurement of biochemical profiles in the healthy fetal brain.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Gestational Age; Humans; | 2020 |
Distinct contributions of two choline-producing enzymatic activities to lysophosphatidic acid production in human amniotic fluid from pregnant women in the second trimester and after parturition.
Topics: Amniotic Fluid; Choline; Female; Humans; Lysophosphatidylcholines; Lysophospholipids; Parturition; P | 2020 |
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
Topics: Angiotensin II; Animals; Aorta; Body Weight; Cholesterol, Dietary; Choline; Endothelium, Vascular; F | 2020 |
Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness.
Topics: Adult; Black or African American; Choline; Female; Gestational Age; Humans; Infant, Newborn; Mental | 2021 |
Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol | 2020 |
Maternal body condition influences neonatal calf whole-blood innate immune molecular responses to ex vivo lipopolysaccharide challenge.
Topics: Animals; Animals, Newborn; Antioxidants; Body Constitution; Cattle; Cattle Diseases; Choline; Female | 2021 |
Short communication: Effects of dietary deoiled soy lecithin supplementation on circulating choline and choline metabolites, and the plasma phospholipid profile in Holstein cows fed palm fat.
Topics: Animals; Cattle; Choline; Diet; Dietary Supplements; Female; Glycine max; Lactation; Lecithins; Medi | 2021 |
Low Maternal Dietary Intake of Choline Regulates Toll-Like Receptor 4 Expression Via Histone H3K27me3 in Fetal Mouse Neural Progenitor Cells.
Topics: Animals; Cell Differentiation; Choline; Choline Deficiency; Epigenesis, Genetic; Ethanol; Female; Ge | 2021 |
Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism.
Topics: Adipogenesis; Choline; Cohort Studies; DNA Methylation; Energy Metabolism; Female; Fetal Blood; Feta | 2021 |
Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age.
Topics: Cannabis; Child; Child Development; Child, Preschool; Choline; Female; Fetal Development; Hallucinog | 2022 |
Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study.
Topics: Adult; Asian People; Case-Control Studies; China; Choline; Diet; Diet Surveys; Eating; Female; Genot | 2020 |
Baseline red blood cell and breast milk DHA levels affect responses to standard dose of DHA in lactating women on a controlled feeding diet.
Topics: Adult; Breast Feeding; Choline; Chromatography, Gas; Cohort Studies; Diet; Dietary Supplements; Doco | 2021 |
Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Appetite Regulation; Body Wei | 2021 |
Spectroscopy analysis of endometrial metabolites is a powerful predictor of success of embryo transfer in women with implantation failure: a preliminary study.
Topics: Adult; Case-Control Studies; Choline; Embryo Implantation; Embryo Transfer; Endometrium; Female; Hum | 2021 |
The effect of choline availability from gestation to early development on brain and retina functions and phospholipid composition in a male mouse model.
Topics: Animals; Brain; Choline; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Phosphatidy | 2022 |
Antiseizure medications and fetal nutrients: Effects on choline transporters in a human placental cell line.
Topics: Adult; Anticonvulsants; Antigens, CD; Cell Line; Choline; Female; Fetus; Folic Acid; Gene Expression | 2021 |
The role of maternal nutrition during pregnancy in the intergenerational transmission of childhood adversity.
Topics: Adverse Childhood Experiences; Choline; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal Syst | 2021 |
Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study.
Topics: Adult; Betaine; Biomarkers; Child; Choline; Cohort Studies; Female; Humans; Male; Pregnancy; Prenata | 2021 |
Editor's Note to: Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness.
Topics: Black or African American; Choline; Female; Gestational Age; Humans; Mental Disorders; Pregnancy; Pr | 2021 |
Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV.
Topics: Child, Preschool; Choline; Female; Humans; Inflammation; Intelligence; Male; Mothers; Pregnancy; Pre | 2021 |
The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice.
Topics: Adult; Animals; Case-Control Studies; Cells, Cultured; Choline; Diabetes, Gestational; Extracellular | 2021 |
Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta.
Topics: Animals; Brain; Choline; Dietary Supplements; DNA Methylation; Ethanol; Female; Fertilization; Fetal | 2021 |
Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; DNA Methylation; Epige | 2017 |
Choline Supplementation During Pregnancy Protects Against Gestational Lipopolysaccharide-Induced Inflammatory Responses.
Topics: Animals; Choline; Cytokines; Dietary Supplements; Female; Inflammation; Lipopolysaccharides; Placent | 2018 |
Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort.
Topics: Adult; Anxiety; Betaine; Choline; Cohort Studies; Depression; Female; Humans; Personal Satisfaction; | 2017 |
Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner.
Topics: Animals; Apoptosis; Biomarkers; Choline; Cytokines; Dietary Supplements; Drug Evaluation, Preclinica | 2017 |
Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring.
Topics: Adult; Air Pollutants; Air Pollution; Case-Control Studies; Choline; Diet Records; Eating; Female; F | 2017 |
Differences in liver functionality indexes in peripartal dairy cows fed rumen-protected methionine or choline are associated with performance, oxidative stress status, and plasma amino acid profiles.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Cattle; Choline; Diet; Dietary Sup | 2017 |
Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats.
Topics: Aging; Animals; Choline; Dizocilpine Maleate; Doublecortin Protein; Female; Hippocampus; Male; Memor | 2017 |
Beneficial effects of postnatal choline supplementation on long-Term neurocognitive deficit resulting from fetal-Neonatal iron deficiency.
Topics: Anemia, Iron-Deficiency; Animals; Animals, Newborn; Choline; Dietary Supplements; Female; Hippocampu | 2018 |
Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity.
Topics: Adiposity; Animals; Blood Glucose; Choline; Diet, High-Fat; Dietary Supplements; Disease Models, Ani | 2017 |
Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity.
Topics: Animals; Biomarkers; Choline; Diet, High-Fat; Dietary Supplements; Fatty Acid Transport Proteins; Fe | 2017 |
Effects of supplementation with ruminally protected choline on performance of multiparous Holstein cows did not depend upon prepartum caloric intake.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Choline; Diet; Dietary Supplements; Energy Intake; Energy Me | 2018 |
Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study.
Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Cerebrovascular Circulation; Choline; Creatine; | 2018 |
Choline.
Topics: Adolescent; Adult; Child; Child, Preschool; Choline; Choline Deficiency; Diet; Female; Humans; Infan | 2018 |
Maternal Choline Supplementation during Normal Murine Pregnancy Alters the Placental Epigenome: Results of an Exploratory Study.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Base Sequence; Choline; Dietary Su | 2018 |
Implantation loss induced by ethanolamine in the rat is ameliorated by a choline-supplemented diet.
Topics: Animals; Choline; Dietary Supplements; Embryo Implantation; Ethanolamine; Female; Male; Pregnancy; R | 2018 |
Fetal one-carbon nutrient concentrations may be affected by gestational diabetes.
Topics: Adult; Betaine; Carbon; Choline; Diabetes, Gestational; Female; Fetal Blood; Fetal Development; Fetu | 2018 |
Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model.
Topics: Animals; Betaine; Caloric Restriction; Carbon; Choline; DNA Methylation; Female; Gene Expression; Ho | 2018 |
Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease.
Topics: Animals; Chelating Agents; Choline; Copper; Copper-Transporting ATPases; Disease Models, Animal; DNA | 2018 |
PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women.
Topics: Adolescent; Adult; Alleles; Betaine; Birth Weight; Carnitine; Choline; Choline-Phosphate Cytidylyltr | 2018 |
Effect of rumen-protected B vitamins and choline supplementation on health, production, and reproduction in transition dairy cows.
Topics: Animal Welfare; Animals; Cattle; Choline; Diet; Female; Lactation; Milk; Postpartum Period; Pregnanc | 2018 |
Methionine and choline supply during the peripartal period alter polymorphonuclear leukocyte immune response and immunometabolic gene expression in Holstein cows.
Topics: Animals; Biomarkers; Cattle; Choline; Diet; Dietary Supplements; Female; Gene Expression Regulation; | 2018 |
Methionine and choline supply alter transmethylation, transsulfuration, and cytidine 5'-diphosphocholine pathways to different extents in isolated primary liver cells from dairy cows.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cattle; Cells, Cultured; Choline; Cytidine Diphos | 2018 |
Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts.
Topics: Animal Feed; Animals; Betaine; Biomarkers; Blood Glucose; Cell Line, Tumor; Choline; Diabetes, Gesta | 2018 |
Neuro-Regenerative Choline-Functionalized Injectable Graphene Oxide Hydrogel Repairs Focal Brain Injury.
Topics: Animals; Brain Injuries; Cells, Cultured; Choline; Female; Graphite; Hydrogels; Injections, Intraven | 2019 |
Development and validation of a quantitative choline food frequency questionnaire for use with drinking and non-drinking pregnant women in Cape Town, South Africa.
Topics: Adult; Alcohol Drinking; Choline; Cohort Studies; Diet; Evaluation Studies as Topic; Female; Humans; | 2018 |
Methyl donor supplementation suppresses the progression of liver lipid accumulation while modifying the plasma triacylglycerol lipidome in periparturient Holstein dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Betaine; Body Weight; Cattle; Choline; Diet; Dietary Supplements; Fe | 2019 |
Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.
Topics: Aspartic Acid; Brain; Brain Injuries; Cerebellum; Choline; Creatine; Female; Gestational Age; Gray M | 2019 |
Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight.
Topics: Adult; Betaine; Birth Weight; Choline; Female; Homocysteine; Humans; Infant, Newborn; Infant, Small | 2019 |
Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development.
Topics: Adult; Brain; C-Reactive Protein; Choline; Cross-Sectional Studies; Female; Fetal Development; Human | 2019 |
One-Carbon Cofactor Intake and Risk of Neural Tube Defects Among Women Who Meet Folic Acid Recommendations: A Multicenter Case-Control Study.
Topics: Adult; Betaine; Carbon; Case-Control Studies; Choline; Dietary Supplements; Dose-Response Relationsh | 2019 |
Associations between folate and choline intake, homocysteine metabolism, and genetic polymorphism of MTHFR, BHMT and PEMT in healthy pregnant Polish women.
Topics: Adolescent; Adult; Betaine-Homocysteine S-Methyltransferase; Choline; Female; Folic Acid; Genotype; | 2020 |
Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows.
Topics: Abomasum; Animals; Betaine; Cattle; Choline; Cystathionine beta-Synthase; Diet; Energy Metabolism; F | 2019 |
Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model.
Topics: Animals; Choline; Craniofacial Abnormalities; Disease Models, Animal; Ethanol; Female; Fetal Alcohol | 2019 |
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome.
Topics: Animals; Basal Forebrain; Choline; Cholinergic Neurons; Dietary Supplements; Disease Models, Animal; | 2019 |
Effects of abomasal infusions of fatty acids and one-carbon donors on hepatic ceramide and phosphatidylcholine in lactating Holstein dairy cows.
Topics: Abomasum; Animals; Cattle; Ceramides; Choline; Diet; Docosahexaenoic Acids; Fatty Acids; Female; Lac | 2019 |
Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Models, A | 2019 |
Hepatic betaine-homocysteine methyltransferase and methionine synthase activity and intermediates of the methionine cycle are altered by choline supply during negative energy balance in Holstein cows.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Abomasum; Animals; Betaine-Homocysteine S | 2019 |
Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring.
Topics: Adult; Brain; Choline; Female; Fetal Development; Gestational Age; Humans; Infant; Infant, Newborn; | 2020 |
Trimethylamine N-Oxide Metabolites in Early Pregnancy and Risk of Gestational Diabetes: A Nested Case-Control Study.
Topics: Adult; Betaine; Blood Glucose; Carnitine; Case-Control Studies; China; Choline; Diabetes, Gestationa | 2019 |
Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing POMC neurons of the hypothalamus.
Topics: Animals; beta-Endorphin; Choline; Dietary Supplements; DNA Methylation; Female; Histones; Hypothalam | 2013 |
Choline intake during pregnancy and child cognition at age 7 years.
Topics: Adult; Betaine; Child; Child Development; Choline; Cognition; Dietary Supplements; Female; Folic Aci | 2013 |
Prevention of schizophrenia: an impossible dream?
Topics: Attention; Brain; Choline; Female; Humans; Male; Neural Inhibition; Nootropic Agents; Phosphorylchol | 2013 |
Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight.
Topics: Betaine; Birth Weight; Choline; Female; Humans; Infant, Newborn; Male; Pregnancy; Sarcosine; Umbilic | 2013 |
Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.
Topics: Adult; Betaine; Choline; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Lon | 2013 |
Methylation metabolites in amniotic fluid depend on gestational age.
Topics: Adult; Amniotic Fluid; Betaine; Choline; Female; Gestational Age; Humans; Methionine; Methylation; M | 2013 |
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Choline; Disease Models, Animal; Doublecortin D | 2013 |
A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.
Topics: Aminohydrolases; Animals; Cell Proliferation; Cells, Cultured; Choline; Congenital Abnormalities; Em | 2013 |
Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants.
Topics: Adult; Betaine; British Columbia; Child Development; Choline; Dietary Supplements; Female; Folic Aci | 2013 |
Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.
Topics: Age Factors; Animals; Cell Count; Cell Size; Choline; Choline O-Acetyltransferase; Cholinergic Fiber | 2014 |
Breast milk choline contents are associated with inflammatory status of breastfeeding women.
Topics: Breast Feeding; C-Reactive Protein; Choline; Colostrum; Female; Humans; Milk, Human; Peptide Fragmen | 2014 |
Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease.
Topics: Animal Nutritional Physiological Phenomena; Animals; Choline; Copper; Cyclin D1; Diet; DNA Methylati | 2014 |
Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Choline; Diet | 2014 |
[Influence of feeding rumen-protected choline to transition dairy cows. Part 1: metabolism and milk yield].
Topics: Animal Feed; Animals; Cattle; Choline; Dairying; Dietary Supplements; Energy Metabolism; Female; Lac | 2014 |
Applied choline-omics: lessons from human metabolic studies for the integration of genomics research into nutrition practice.
Topics: Choline; Epigenomics; Female; Genotype; Humans; Hydrocortisone; Male; Maternal Nutritional Physiolog | 2014 |
Dietary intake of choline and neural tube defects in Mexican Americans.
Topics: Adult; Betaine; Case-Control Studies; Choline; Dietary Supplements; Female; Humans; Mexican American | 2014 |
Audiogenic seizure proneness after methyl-enriched diet in ontogeny.
Topics: Animals; Betaine; Choline; Diet; DNA Methylation; Epilepsy, Reflex; Female; Methionine; Pregnancy; P | 2014 |
Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors.
Topics: Animals; Anxiety Disorders; Body Weight; Choline; Dietary Supplements; Exploratory Behavior; Female; | 2014 |
Estimation of choline intake from 24 h dietary intake recalls and contribution of egg and milk consumption to intake among pregnant and lactating women in Alberta.
Topics: Adolescent; Adult; Alberta; Animals; Choline; Cohort Studies; Databases, Factual; Eggs; Female; Huma | 2014 |
Metabolic characterization of all-trans-retinoic acid (ATRA)-induced craniofacial development of murine embryos using in vivo proton magnetic resonance spectroscopy.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Choline; Cleft Palate; Craniofacial Abn | 2014 |
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.
Topics: Aging; Animals; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Supple | 2014 |
Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice.
Topics: Animals; Choline; Dietary Supplements; Docosahexaenoic Acids; Down Syndrome; Female; Lipid Metabolis | 2014 |
Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet.
Topics: Adipose Tissue; Animals; Betaine; Body Composition; Choline; Diet; Diet, High-Fat; Dietary Sucrose; | 2014 |
The effect of hypoxia-induced intrauterine growth restriction on renal artery function.
Topics: Animals; Choline; Female; Fetal Growth Retardation; Hypoxia; Male; Nitric Oxide; Phenylephrine; Preg | 2012 |
Increased systolic blood pressure in rat offspring following a maternal low-protein diet is normalized by maternal dietary choline supplementation.
Topics: Animals; Blood Pressure; Body Weight; Choline; Diet, Protein-Restricted; Dietary Supplements; Female | 2012 |
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood; | 2015 |
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood; | 2015 |
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood; | 2015 |
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood; | 2015 |
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.
Topics: Adult; Betaine; Case-Control Studies; Choline; Dietary Supplements; Female; Folic Acid; Genome, Huma | 2014 |
Maternal methyl-enriched diet in rat reduced the audiogenic seizure proneness in progeny.
Topics: Animals; Animals, Newborn; Betaine; Choline; Diet; Epilepsy, Reflex; Female; Folic Acid; Male; Mater | 2014 |
High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Choline; Disease Models, Animal; Dose-Respons | 2015 |
Prenatal choline supplementation ameliorates the long-term neurobehavioral effects of fetal-neonatal iron deficiency in rats.
Topics: Animals; Animals, Newborn; Choline; Dietary Supplements; Female; Gene Expression Regulation; Hematoc | 2014 |
Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus.
Topics: Age Factors; Animals; Binding Sites; Brain-Derived Neurotrophic Factor; Choline; Chromatin Assembly | 2015 |
Vascular effects of aerobic exercise training in rat adult offspring exposed to hypoxia-induced intrauterine growth restriction.
Topics: Animals; Choline; Endothelium, Vascular; Female; Fetal Growth Retardation; Hypoxia; Male; Mesenteric | 2015 |
The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Autistic Disorder; Behavior, Animal; Choline; Dise | 2015 |
Molecular and functional characterization of choline transporter in the human trophoblastic cell line JEG-3 cells.
Topics: Animals; Biological Transport; Cell Line, Tumor; Chlorocebus aethiops; Choline; COS Cells; Female; H | 2015 |
Choline is required in the diet of lactating dams to maintain maternal immune function.
Topics: Animals; Body Weight; Choline; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Energy I | 2015 |
Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations.
Topics: Adolescent; Adult; Betaine; Canada; Choline; Female; Fetal Blood; Fetus; Genotype; Healthy Volunteer | 2015 |
Effects of rumen-protected choline supplementation on metabolic and performance responses of transition dairy cows.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Blood Glucose; Cattle; Choline; Diet; Dietary Supplemen | 2015 |
Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig.
Topics: Animals; Animals, Newborn; Brain; Choline; Choline Deficiency; Diet; Diffusion Tensor Imaging; Disea | 2016 |
Pregnant Canadian Women Achieve Recommended Intakes of One-Carbon Nutrients through Prenatal Supplementation but the Supplement Composition, Including Choline, Requires Reconsideration.
Topics: Adult; Canada; Choline; Dietary Supplements; Female; Humans; Maternal Nutritional Physiological Phen | 2015 |
Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Central Nervous System Depressants; Ch | 2015 |
Choline deficiency impairs intestinal lipid metabolism in the lactating rat.
Topics: Animals; Choline; Choline Deficiency; Diet; Esterification; Fatty Acids; Female; Intestinal Mucosa; | 2015 |
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline; Diet; Dietary Supplements | 2016 |
Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome.
Topics: Age Factors; Aging; Animals; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Synd | 2016 |
Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Choline; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Hum | 2016 |
Elucidating Metabolic Maturation in the Healthy Fetal Brain Using 1H-MR Spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; Gestational Age; H | 2016 |
Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis.
Topics: Basal Ganglia; Brain; Choline; Chorioamnionitis; Creatine; Dipeptides; Female; Healthy Volunteers; H | 2015 |
Suppression of Mammary Carcinogenesis Through Early Exposure to Dietary Lipotropes Occurs Primarily In Utero.
Topics: Animals; Animals, Newborn; Choline; Chromatin Assembly and Disassembly; Diet; Female; Folic Acid; Hi | 2015 |
The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants.
Topics: Adult; Central Nervous System Depressants; Choline; Dietary Supplements; Ethanol; Female; Fetal Alco | 2015 |
Characterization of choline transporters in the human placenta over gestation.
Topics: Choline; Chorionic Villi; Female; Humans; Membrane Transport Proteins; Placenta; Pregnancy; Trophobl | 2015 |
Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring.
Topics: Animals; Blotting, Western; Cell Count; Cells, Cultured; Cerebral Cortex; Choline; Choline Deficienc | 2016 |
Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus.
Topics: Animals; Animals, Newborn; Behavior, Animal; Choline; Dietary Supplements; Female; Fetus; Gene Expre | 2016 |
Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Male; Maze Le | 2016 |
Prenatal choline supplementation attenuates spatial learning deficits of offspring rats exposed to low-protein diet during fetal period.
Topics: Animals; Animals, Newborn; Behavior, Animal; CA1 Region, Hippocampal; Choline; Diet, Protein-Restric | 2016 |
Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride.
Topics: ADAMTS4 Protein; Aggrecans; Animals; Choline; Chondrocytes; Extracellular Matrix; Female; Fluorides; | 2017 |
Maternal Methyl-Group Donor Intake and Global DNA (Hydroxy)Methylation before and during Pregnancy.
Topics: 5-Methylcytosine; Adult; Belgium; Betaine; Biomarkers; Choline; Cohort Studies; Cytosine; Diet; Diet | 2016 |
A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group.
Topics: Child, Preschool; Choline; Dietary Supplements; Female; Folic Acid; Gene-Environment Interaction; Ge | 2016 |
Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.
Topics: Animals; Choline; Copper; Dietary Supplements; Disease Models, Animal; DNA Methylation; Epigenomics; | 2016 |
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Echoencephalography; Female; Fetus; Glutamic Acid; | 2016 |
Choline and the Brain: An Epigenetic Perspective.
Topics: Animals; Betaine; Brain; Choline; Dietary Supplements; DNA Methylation; Environment; Epigenesis, Gen | 2016 |
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.
Topics: Aminohydrolases; Animals; Choline; Dietary Supplements; Embryo, Mammalian; Embryonic Development; Fe | 2016 |
Perinatal Dietary Choline Deficiency in Sows Influences Concentrations of Choline Metabolites, Fatty Acids, and Amino Acids in Milk throughout Lactation.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline; Choline Defi | 2016 |
Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs.
Topics: Age Factors; Animals; Binge Drinking; Brain; Choline; Disease Models, Animal; Female; Male; Neuropro | 2016 |
Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation.
Topics: Adult; Betaine; Choline; Cohort Studies; Diet; Dietary Supplements; DNA Methylation; Epigenomics; Fe | 2017 |
Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring.
Topics: Animals; Attention; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Su | 2017 |
Micronutrient Intake Is Inadequate for a Sample of Pregnant African-American Women.
Topics: Adolescent; Adult; Black or African American; Body Mass Index; Calcium, Dietary; Choline; Energy Int | 2017 |
Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Biomarkers; Choline; Female; Humans; Hypoxia-Ischemi | 2017 |
Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Animals, Newborn; Choline; | 2017 |
Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants.
Topics: Betaine; Choline; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Meth | 2017 |
Neonatal alcohol-induced region-dependent changes in rat brain neurochemistry measured by high-resolution magnetic resonance spectroscopy.
Topics: Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Body Weight; Cerebellum; Cerebrum; Choline; E | 2008 |
Apomorphine offers new insight into dopaminergic neuron vulnerability in mesencephalic cultures.
Topics: Animals; Apomorphine; Cell Survival; Cells, Cultured; Choline; Dopamine; Dopamine Agonists; Dopamine | 2008 |
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Bungarotoxins; Choline; Choline Deficiency; Evoked | 2008 |
Prenatal choline supplementation increases sensitivity to contextual processing of temporal information.
Topics: Animals; Behavior, Animal; Choline; Conditioning, Operant; Dietary Supplements; Female; Male; Nootro | 2008 |
Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Cell Proliferation; Choline; Choline Deficiency; Dieta | 2008 |
Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration.
Topics: Age Factors; Alcohols; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weigh | 2008 |
Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; C | 2008 |
Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex.
Topics: Acetylcholine; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Choline; Female; Fronta | 2008 |
Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation.
Topics: Algorithms; Animals; Biological Clocks; Choline; Dietary Supplements; Electroencephalography; Electr | 2008 |
Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats.
Topics: Acoustic Stimulation; Aging; Animals; Behavior, Animal; Choline; Dietary Supplements; Discrimination | 2008 |
Choline in the treatment of infant toxicosis.
Topics: Bacterial Infections; Choline; Disease; Female; Infant; Nutritional Sciences; Pre-Eclampsia; Pregnan | 1948 |
Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Animals; Apoptosis; Brain; Caspase 3; Cholin | 2009 |
Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain.
Topics: Animals; Brain; Choline; CpG Islands; Female; Fetus; Gene Expression Regulation, Developmental; Gene | 2009 |
Hypospadias and intake of nutrients related to one-carbon metabolism.
Topics: Carbon; Choline; Diet; Dietary Supplements; Female; Folic Acid; Humans; Hypospadias; Infant, Newborn | 2009 |
(1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility study.
Topics: Adolescent; Adult; Amniotic Fluid; Biomarkers; Choline; Female; Fetal Organ Maturity; Humans; Lung; | 2008 |
Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Carcinogens; Choline; Choline Deficiency; | 2009 |
Prenatal choline availability alters the context sensitivity of Pavlovian conditioning in adult rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Association Learning; Choline; Choline Deficiency; | 2008 |
Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT.
Topics: Acetylcholine; Animals; Base Sequence; Biological Transport, Active; Catecholamine Plasma Membrane T | 2009 |
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy.
Topics: Animals; Choline; Female; Gestational Age; Humans; Lysophosphatidylcholines; Lysophospholipids; Mult | 2009 |
[Methyl-containing diet of mothers affects the AGOUTI gene expression in the offspring of rats with various behavioral types].
Topics: Aggression; Agouti Signaling Protein; Animals; Behavior, Animal; Betaine; Choline; Dietary Supplemen | 2009 |
Investigation on the effect of supplementing rumen-protected forms of methionine and choline on health situation and reproductive performance of Holstein dairy cows.
Topics: Animal Feed; Animals; Cattle; Choline; Dairying; Dietary Supplements; Female; Health Status; Lactati | 2009 |
Effect of chorioamnionitis on brain development and injury in premature newborns.
Topics: Anisotropy; Aspartic Acid; Brain; Brain Diseases; Choline; Chorioamnionitis; Diffusion Magnetic Reso | 2009 |
Methyl donor deficiency affects fetal programming of gastric ghrelin cell organization and function in the rat.
Topics: Animals; Body Weight; Cell Lineage; Choline; Deficiency Diseases; Enteroendocrine Cells; Female; Fet | 2010 |
Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Choline; Female; Gestational Age; Heart Defects, Congenital; Humans; Imaging, | 2010 |
Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.
Topics: Animals; Choline; Diet; Female; Fetal Heart; Heart; Heart Defects, Congenital; Homocysteine; Lipotro | 2010 |
Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood.
Topics: Animals; Choline; Female; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Hum | 2011 |
The actions and obstetric applications of carbaminoylcholine.
Topics: Choline; Female; Humans; Labor, Obstetric; Pharmaceutical Preparations; Pregnancy; Work | 1947 |
Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain.
Topics: Animals; Apoptosis; Brain; Choline; Female; Fetus; Folic Acid Deficiency; Mice; Mice, Inbred C57BL; | 2010 |
Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome.
Topics: Aging; Animals; Attention; Choline; Cognition; Dietary Supplements; Disease Models, Animal; Down Syn | 2010 |
Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet.
Topics: Abnormalities, Drug-Induced; Animals; Betaine; Choline; Diet; DNA Methylation; Drug Resistance; Etha | 2011 |
Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Bulimia; Choline; Dietary Supplements; Eth | 2010 |
Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study.
Topics: Arachidonic Acid; Child Development; Child Nutritional Physiological Phenomena; Child, Preschool; Ch | 2011 |
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A | 2011 |
Use of canonical variate analysis biplot in examination of choline content data of some foods.
Topics: Choline; Female; Food Analysis; Humans; Male; Pregnancy | 2011 |
Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes.
Topics: Animals; Bacteria; Betaine; Choline; Colitis; Dietary Supplements; Disease Susceptibility; DNA Methy | 2011 |
Policy statement on folic acid and neural tube defects.
Topics: Choline; Dietary Supplements; Female; Folic Acid; Humans; Neural Tube Defects; Pregnancy; Vitamin B | 2011 |
Effect of rumen-protected choline on performance, blood metabolites, and hepatic triacylglycerols of periparturient dairy cattle.
Topics: Animal Feed; Animals; Blood Glucose; Cattle; Choline; Dietary Supplements; Eating; Fatty Acids, None | 2011 |
Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Disease Susceptibility; Female; Hippocampus; Kain | 2011 |
Non-targeted analyses of animal plasma: betaine and choline represent the nutritional and metabolic status.
Topics: Animals; Betaine; Cattle; Chickens; Choline; Diabetes Mellitus, Experimental; Female; Male; Mice; Mi | 2013 |
Cerebellar volume and proton magnetic resonance spectroscopy at term, and neurodevelopment at 2 years of age in preterm infants.
Topics: Aspartic Acid; Brain Mapping; Cerebellum; Child, Preschool; Choline; Cognition Disorders; Developmen | 2012 |
Altered placental methyl donor transport in the dexamethasone programmed rat.
Topics: Animals; Biological Transport; Choline; Dexamethasone; DNA Methylation; Embryonic Development; Epist | 2012 |
Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome.
Topics: Animals; Avitaminosis; Choline; Epigenesis, Genetic; Female; Fetal Alcohol Spectrum Disorders; Folic | 2012 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Emb | 2012 |
Gestational intake of methyl donors and global LINE-1 DNA methylation in maternal and cord blood: prospective results from a folate-replete population.
Topics: Adult; Betaine; Choline; Diet; Dietary Supplements; DNA Methylation; Female; Fetal Blood; Folic Acid | 2012 |
The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt.
Topics: Acetylcholine; Animals; Animals, Newborn; Behavior, Animal; Choline; Dietary Supplements; Ethanol; F | 2012 |
Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat.
Topics: Animals; Choline; Cysteine; Diet; Female; Fetus; Folic Acid; Homocysteine; Kinetics; Litter Size; Li | 2012 |
Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Lineage; Choline; Female; Homologous Recombin | 2012 |
Choline supplementation and DNA methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development.
Topics: Animals; Animals, Newborn; Choline; Dietary Supplements; DNA Methylation; Ethanol; Female; Hippocamp | 2012 |
Maternal intake of methyl-donor nutrients and child cognition at 3 years of age.
Topics: Adult; Betaine; Child Development; Child, Preschool; Choline; Cognition; Cohort Studies; Diet; DNA M | 2012 |
Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women.
Topics: Adult; Animals; Choline; Diet; Docosahexaenoic Acids; Erythrocytes; Fatty Acids, Omega-3; Female; Fi | 2013 |
The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins.
Topics: 5' Untranslated Regions; Animals; Birth Weight; Cattle; Cell Proliferation; Choline; Dystocia; Exons | 2012 |
MR spectroscopy of the fetal brain: is it possible without sedation?
Topics: Aspartic Acid; Brain; Choline; Conscious Sedation; Creatine; Female; Fetal Diseases; Fetal Growth Re | 2013 |
Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants.
Topics: Betaine; Child Development; Choline; Cognition; Female; Humans; Infant; Male; Pregnancy; Pregnancy T | 2012 |
Postnatal choline levels mediate cognitive deficits in a rat model of schizophrenia.
Topics: Animals; Choline; Choline Deficiency; Cognition Disorders; Disease Models, Animal; Dizocilpine Malea | 2012 |
Methyl group balance in brain and liver: role of choline on increased S-adenosyl methionine (SAM) demand by chronic arsenic exposure.
Topics: Animals; Arsenic; Arsenic Poisoning; Brain; Choline; Female; Immunohistochemistry; Liver; Male; Meth | 2012 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo | 2013 |
Following healthy pregnancy by nuclear magnetic resonance (NMR) metabolic profiling of human urine.
Topics: Acids, Acyclic; Adult; Amino Acids; Biomarkers; Choline; Creatinine; Female; Humans; Magnetic Resona | 2013 |
High maternal choline intake may prevent the development of stress-related disorders through epigenetic mechanisms.
Topics: Choline; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Humans; Hyd | 2012 |
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
Topics: Betaine; Child Development; Child, Preschool; Choline; Cognition; Female; Homocysteine; Humans; Lang | 2013 |
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice.
Topics: Animals; Betaine; Choline; Craniofacial Abnormalities; Dietary Supplements; Disease Models, Animal; | 2013 |
Metabolic profiling of plasma from sows before parturition and during lactation using a liquid chromatography-mass spectrometry-based approach.
Topics: Animals; Betaine; Choline; Chromatography, Liquid; Female; Lactation; Lipids; Mass Spectrometry; Par | 2012 |
Long-lasting effects of prenatal dietary choline availability on object recognition memory ability in adult rats.
Topics: Animals; Behavior, Animal; Choline; Choline Deficiency; Dietary Supplements; Female; Male; Maternal | 2013 |
Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats.
Topics: Aging; Animals; Cell Size; Choline; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Male; Me | 2002 |
Maturation of the human fetal brain as observed by 1H MR spectroscopy.
Topics: Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Female; Fetus; Gestational Age; Humans; Inosito | 2002 |
Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors.
Topics: Animals; Cell Line; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Syndrome; Fem | 2002 |
Birth of two babies using oocytes that were cryopreserved in a choline-based freezing medium.
Topics: Adult; Choline; Cryopreservation; Embryo Implantation; Embryo Transfer; Female; Gestational Age; Hum | 2002 |
Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline.
Topics: Animals; Apoptosis; Choline; Diet; DNA Fragmentation; Fatty Liver; Female; Humans; In Situ Nick-End | 2003 |
Free and phospholipid-bound choline concentrations in serum during pregnancy, after delivery and in newborns.
Topics: Cesarean Section; Choline; Female; Gestational Age; Humans; Infant, Newborn; Labor, Obstetric; Phosp | 2002 |
Sodium transport across the chorioallantoic membrane of porcine placenta involves the epithelial sodium channel (ENaC).
Topics: Amiloride; Animals; Biological Transport; Blotting, Western; Choline; Chorion; Diuretics; Enzyme Inh | 2003 |
Effect of exogenous surfactant on the development of surfactant synthesis in premature rabbit lung.
Topics: Animals; Biological Products; Carbon Radioisotopes; Choline; Drug Combinations; Fatty Alcohols; Fema | 2003 |
Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Choline; Choline Deficiency; Diet; Dizocilpine Maleate; | 2003 |
Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus.
Topics: Aging; Animals; Calbindin 2; Choline; Choline Deficiency; Embryonic and Fetal Development; Female; G | 2003 |
Liver metabolism and production of cows fed increasing amounts of rumen-protected choline during the periparturient period.
Topics: 3-Hydroxybutyric Acid; Animals; Body Composition; Body Weight; Cattle; Choline; Dietary Supplements; | 2003 |
Antenatal proton MR spectroscopy of the human brain in vivo.
Topics: Aspartic Acid; Brain; Choline; Creatine; Female; Fetus; Gestational Age; Humans; Inositol; Magnetic | 2003 |
Reversible posterior leukoencephalopathy in eclampsia.
Topics: Adult; Aspartic Acid; Cerebral Arterial Diseases; Choline; Creatine; Female; Humans; Inositol; Magne | 2003 |
Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung.
Topics: Amino Acid Sequence; Animals; Bombesin; Cell Differentiation; Cell Division; Choline; Dexamethasone; | 2004 |
[Carbaminoylcholine in Soskin test].
Topics: Amenorrhea; Choline; Female; Humans; Pregnancy; Pregnancy Tests | 1953 |
[Effect of PAS, streptomycin and choline during pregnancy].
Topics: Aminosalicylic Acid; Choline; Female; Fetus; Pregnancy; Streptomycin | 1953 |
[The choline content of the human placenta, its function and its significance for the etiology of toxicosis].
Topics: Choline; Female; Humans; Inactivation, Metabolic; Placenta; Pre-Eclampsia; Pregnancy | 1954 |
[Effect of neurovegetative system on immunity transmitted through placental barrier].
Topics: Antibodies; Antigens; Atropine; Choline; Epinephrine; Ergot Alkaloids; Female; Humans; Placenta; Pre | 1955 |
Peripheral vascular reactions in normal subjects, normal pregnancy and toxaemia of pregnancy.
Topics: Bacterial Infections; Choline; Female; Histamine; Histamine Agents; Pre-Eclampsia; Pregnancy; Sepsis | 1956 |
[Pregnancy in choline-deficient diets].
Topics: Choline; Choline Deficiency; Diet; Female; Humans; Pregnancy | 1958 |
Hemoglobin synthesis with iron choline citrate in hypochromic anemia of pregnancy.
Topics: Anemia; Anemia, Hypochromic; Anemia, Sideroblastic; Choline; Female; Genetic Diseases, X-Linked; Hem | 1960 |
Periplacental hemorrhage and renal necrosis in protein and choline deficient pregnant rats following progesterone administration. A preliminary report.
Topics: Animals; Choline; Choline Deficiency; Female; Hemorrhage; Humans; Kidney Diseases; Pregnancy; Pregna | 1960 |
THE ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN UTERINE CONTRACTILITY AND BLOOD FLOW. II. THE ROLE OF THE PARASYMPATHETIC NEUROHORMONE ACETYLCHOLINE IN UTERINE MOTILITY AND BLOOD FLOW.
Topics: Acetylcholine; Animals; Animals, Newborn; Autonomic Nervous System; Blood Circulation; Carbachol; Ch | 1964 |
A COMPARISON OF THE N-ALKYL GROUP SPECIFICITY OF CHOLINE ACETYLTRANSFERASE FROM DIFFERENT SPECIES.
Topics: Acetylcholine; Acyltransferases; Ammonium Compounds; Animals; Brain; Choline; Choline O-Acetyltransf | 1964 |
STUDIES USING CLOSTRIDIUM BOTULINUM TOXIN--TYPE A.
Topics: Acetylcholine; Antitoxins; Barbiturates; Botulinum Toxins; Brain Chemistry; Calcium; Chlorpromazine; | 1965 |
The effect of a choline deficient diet in young pregnant rats.
Topics: Animals; Choline; Choline Deficiency; Diet; Female; Humans; Nutrition Assessment; Pregnancy; Prenata | 1960 |
The renal lesions associated with intrauterine haemorrhage and foetal death in pregnant rats given progesterone and an experimental diet.
Topics: Animals; Choline; Choline Deficiency; Diet; Female; Fetal Death; Fetus; Hemorrhage; Humans; Kidney; | 1962 |
Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus.
Topics: Animals; Apoptosis; Biological Availability; Brain; Choline; Embryonic and Fetal Development; Female | 2003 |
Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes.
Topics: Adult; Arachidonic Acid; Choline; Diabetes Mellitus; Diabetes, Gestational; Docosahexaenoic Acids; E | 2004 |
Dietary prenatal choline supplementation alters postnatal hippocampal structure and function.
Topics: Action Potentials; Animals; Animals, Newborn; Cell Count; Cell Size; Choline; Dietary Supplements; E | 2004 |
Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
Topics: Animals; Choline; Choline Deficiency; Cues; Cyclic AMP Response Element-Binding Protein; Female; Glu | 2004 |
Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Fractionation; Cells, Cultured | 2004 |
The metabolism of methionine and choline in normal and pre-eclamptic pregnant women.
Topics: Choline; Female; Humans; Methionine; Pre-Eclampsia; Pregnancy | 1951 |
Methionine and choline deficiency in the rat with special reference to the pregnant state.
Topics: Animals; Choline; Choline Deficiency; Female; Methionine; Pregnancy; Rats | 1951 |
Hormone regulation of choline uptake and incorporation in mouse mammary gland explants.
Topics: Animals; Biological Transport; Choline; Culture Techniques; Female; Hydrocortisone; Insulin; Lipid M | 2004 |
Sex-related differences in effect of ethanol administration and folic acid supplementation on pancreatic amylase in rats.
Topics: Amylases; Animals; Body Weight; Central Nervous System Depressants; Choline; Dietary Supplements; Et | 2004 |
Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus.
Topics: Acyltransferases; Animals; Blotting, Western; Brain; Calbindin 2; Choline; Chromatography, High Pres | 2004 |
Periconceptional dietary intake of choline and betaine and neural tube defects in offspring.
Topics: Betaine; California; Case-Control Studies; Choline; Female; Humans; Infant, Newborn; Maternal Nutrit | 2004 |
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys.
Topics: Adenylyl Cyclases; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Brain; Choline; DNA; Female; He | 2005 |
Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells.
Topics: Animals; Cell Separation; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Chromato | 2005 |
Magnetic resonance spectroscopy of premalignant and malignant endometrial disorders: a feasibility of in vivo study.
Topics: Adult; Aged; Choline; Creatine; Endometrial Hyperplasia; Endometrial Neoplasms; Endometrium; Feasibi | 2005 |
Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Brain Stem; Cerebra | 2005 |
Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy.
Topics: Adult; Africa, Western; Betaine; Black People; Choline; Dietary Supplements; Female; Folic Acid; Ges | 2005 |
Choline, homocysteine, and pregnancy.
Topics: Animals; Choline; Choline Deficiency; Female; Homocysteine; Humans; Lactation; Maternal Nutritional | 2005 |
Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery.
Topics: Betaine; Choline; Chromatography, Liquid; Creatinine; Cross-Sectional Studies; Female; Fetal Blood; | 2005 |
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains.
Topics: Animals; Calbindin 2; Choline; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibi | 2006 |
[The effect of methyl-containing supplements during pregnancy on the phenotypic modification of offspring hair color in rats].
Topics: Agouti Signaling Protein; Animals; Betaine; Choline; Color; Dietary Supplements; Electron Spin Reson | 2006 |
Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica.
Topics: Adolescent; Adult; Choline; Diet; Female; Food Analysis; Gas Chromatography-Mass Spectrometry; Human | 2005 |
Maternal methyl supplements increase offspring DNA methylation at Axin Fused.
Topics: Alleles; Animals; Axin Protein; Betaine; Body Weight; Choline; CpG Islands; Diet; Dietary Supplement | 2006 |
Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Central Nervous System Depressants; C | 2006 |
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.
Topics: California; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Female; Genotype; Human | 2006 |
Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells.
Topics: Animals; Apoptosis; Brain; Bromodeoxyuridine; Carbon Radioisotopes; Cell Proliferation; Cells, Cultu | 2007 |
Prenatal choline availability modulates hippocampal and cerebral cortical gene expression.
Topics: Animals; Base Sequence; Blotting, Western; Cerebral Cortex; Choline; Choline Deficiency; Diet; DNA P | 2007 |
Improved cryopreservation of bovine preimplantation embryos cultured in chemically defined medium.
Topics: Animals; Birth Rate; Blastocyst; Cattle; Cell Survival; Choline; Cryopreservation; Culture Media; Em | 2008 |
Choline supplementation following third-trimester-equivalent alcohol exposure attenuates behavioral alterations in rats.
Topics: Alcohols; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Choline; Dose-Response Relations | 2007 |
Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome.
Topics: Acetylcholine; Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Brain; Choline; Di | 2007 |
Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Choline; Choline Deficiency; Female; G | 2007 |
Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus.
Topics: Amino Acids; Animals; Choline; Diet; DNA Methylation; Female; Fetus; Folic Acid; Folic Acid Deficien | 2007 |
Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Choline; Diet; Dietary Supplements; Doublecortin Prote | 2007 |
A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats.
Topics: Age Factors; Animal Feed; Animals; Anxiety; Betaine; Brain; Choline; Critical Period, Psychological; | 2007 |
ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells.
Topics: Animals; Cell Differentiation; Cell Division; Choline; Dimerization; Down-Regulation; Epithelial Cel | 2007 |
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; In | 2007 |
Nutrition fact sheet. Eggs: a good choice for moms-to-be.
Topics: Adult; Choline; Eggs; Female; Humans; Maternal Nutritional Physiological Phenomena; Nutrition Policy | 2007 |
In utero methanesulfonyl fluoride differentially affects learning and maze performance in the absence of long-lasting cholinergic changes in the adult rat.
Topics: Acetylcholinesterase; Animals; Anxiety; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibit | 2008 |
Prenatal choline supplementation increases sensitivity to time by reducing non-scalar sources of variance in adult temporal processing.
Topics: Analysis of Variance; Animals; Choice Behavior; Choline; Dietary Supplements; Female; Male; Mental P | 2007 |
Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants.
Topics: Adolescent; Adult; Betaine; Choline; Choline Dehydrogenase; Female; Gene Expression Regulation, Enzy | 2007 |
Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Choline; Conditioning, Psychological; Dietary Supplem | 2008 |
Supplementing limited methionine diets with rumen-protected methionine, betaine, and choline in early lactation Holstein cows.
Topics: Animal Feed; Animals; Betaine; Body Constitution; Body Weight; Cattle; Choline; Dairying; Diet; Diet | 2008 |
Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus.
Topics: Animals; Choline; Female; Hippocampus; Male; Pregnancy; Prenatal Care; Prenatal Nutritional Physiolo | 2008 |
Choline concentrations in human maternal and cord blood and intelligence at 5 y of age.
Topics: Child Development; Child, Preschool; Choline; Cognition; Female; Fetal Blood; Gestational Age; Human | 2008 |
Metabolic assessment of the brain using proton magnetic resonance spectroscopy in a growth-restricted human fetus: case report.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Child, Preschool; Choline; Female; Fetal Growth Retard | 2008 |
Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Bungarotoxi | 2008 |
Ontogenesis of cholingergic innervation in the rat heart.
Topics: Acetylcholine; Animals; Animals, Newborn; Carnitine O-Acetyltransferase; Chick Embryo; Choline; Elec | 1980 |
Phenylacetate and brain dysfunction in experimental phenylketonuria: synaptic development.
Topics: Animals; Cerebral Cortex; Choline; Female; Fenclonine; gamma-Aminobutyric Acid; Humans; Male; Neurot | 1980 |
Development of GABAergic function of dissociated hippocampal cultures from fetal mice.
Topics: Animals; Autoradiography; Binding, Competitive; Cell Differentiation; Choline; Culture Techniques; F | 1981 |
Electric potential differences in the isolated guinea-pig placenta.
Topics: Animals; Choline; Female; Gramicidin; Guinea Pigs; In Vitro Techniques; Ion Channels; Maternal-Fetal | 1982 |
Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency?
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Female; Humans; Lipotropic Agents; Liver; Pregnan | 1982 |
Ontogeny of opiate mechanisms in relation to the sequential development of neurons known to be components of the guinea pig's enteric nervous system.
Topics: Acetylcholine; Animals; Axons; Choline; Drug Tolerance; Female; Gestational Age; Guinea Pigs; Humans | 1980 |
Effects of the herbicide 2, 4-dichlorophenyl-p-nitrophenyl ether (nitrofen) on fetal lung development in rats.
Topics: Animals; Choline; Diacylglycerol Cholinephosphotransferase; Female; Glucocorticoids; Herbicides; Lun | 1981 |
Evidence for a regulatory role of CTP : choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth.
Topics: Animals; Animals, Newborn; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Cho | 1981 |
Inhibition of phorbol ester-receptor binding by a factor from human serum.
Topics: Animals; Arachidonic Acids; Blood; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Cel | 1982 |
Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport.
Topics: Adult; Bipolar Disorder; Choline; Erythrocytes; Female; Fetal Blood; Humans; Lithium; Lithium Carbon | 1983 |
Kinetics of methionine and choline and their incorporation into plasma lipids and milk components in lactating goats.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Choline; Female; Goats; Infusions, Parenteral; Lactat | 1984 |
Ventilation-induced release of phosphatidylcholine from neonatal-rat lungs in vitro.
Topics: Animals; Animals, Newborn; Calcium; Choline; Diabetes Mellitus, Experimental; Female; Lung; Models, | 1984 |
The rate-limiting reaction in phosphatidylcholine synthesis by alveolar type II cells isolated from fetal rat lung.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Female; Fetus; Kinetics; Lung; Phosphatidylcholines; | 1984 |
The neuroteratogenicity of procarbazine in the rat: behavioral, morphological, and neurochemical aspects.
Topics: Abnormalities, Drug-Induced; Animals; Avoidance Learning; Behavior, Animal; Brain; Choline; Choline | 1984 |
Effect of fibroblast-pneumonocyte factor on the synthesis of surfactant phospholipids in type II cells from fetal rat lung.
Topics: Animals; Cells, Cultured; Choline; Female; Fibroblast Growth Factors; Glycerol; Lung; Oligopeptides; | 1984 |
Influence of the major histocompatibility complex (H-2) on glucocorticoid-stimulated pulmonary surfactant synthesis in two congenic mouse strains.
Topics: Alleles; Animals; Betamethasone; Choline; DNA; Female; Genetic Linkage; H-2 Antigens; Lipids; Lung; | 1984 |
The effect of maternal diabetes on the synthesis and secretion of phosphatidylcholine in fetal and maternal rat lungs in vitro.
Topics: Animals; Blood Glucose; Choline; Diabetes Mellitus, Experimental; Female; Fetal Organ Maturity; Fetu | 1984 |
Alveolar pre-type II cells from the fetal rabbit lung. Isolation and characterization.
Topics: Animals; Cell Adhesion; Cell Differentiation; Cell Separation; Cells, Cultured; Choline; Dexamethaso | 1983 |
Glucocorticoid-thyroid hormone interactions in fetal rat lung.
Topics: Animals; Betamethasone; Binding Sites; Cell Nucleus; Choline; Cytoplasm; Dexamethasone; Dose-Respons | 1984 |
Dietary choline for the lactating cow: possible effects on milk fat synthesis.
Topics: Animals; Cattle; Choline; Fatty Acids, Nonesterified; Fatty Acids, Volatile; Female; Hydrogen-Ion Co | 1984 |
Increase of choline acetyltransferase by colchicine in primary cell cultures of spinal cord.
Topics: Acetylcholinesterase; Animals; Antibodies, Monoclonal; Cells, Cultured; Choline; Choline O-Acetyltra | 1984 |
[Effects of citicholine on pituitary gland function in normal subjects and in cases of idiopathic galactorrhea].
Topics: Adolescent; Adult; Choline; Cimetidine; Cytidine Diphosphate Choline; Female; Galactorrhea; Growth H | 1980 |
Corticosteroid stimulation of phosphatidylcholine synthesis in cultured fetal rabbit lung: evidence for de novo protein synthesis mediated by glucocorticoid receptors.
Topics: Animals; Binding, Competitive; Choline; Dexamethasone; Female; Fetus; Hydrocortisone; Kinetics; Lung | 1983 |
Influence of sex hormones on lung maturation in the fetal rabbit.
Topics: Animals; Choline; Cytosol; Diethylstilbestrol; Estradiol; Female; Gestational Age; Kinetics; Lung; M | 1983 |
Uptake and utilization of CDP-choline in primary brain cell cultures from fetal brain.
Topics: Animals; Brain; Carbon Radioisotopes; Cells, Cultured; Choline; Cytidine Diphosphate Choline; Female | 1983 |
Type II alveolar cells in organotypic culture. A model system for the study of surfactant synthesis.
Topics: Animals; Choline; Female; Glucose; Organ Culture Techniques; Palmitic Acids; Phosphatidylcholines; P | 1980 |
Fetal lung disaturated phosphatidylcholine. Ostensible increase following exposure to dexamethasone.
Topics: Animals; Choline; Dexamethasone; Female; Glucocorticoids; In Vitro Techniques; Lung; Phosphatidylcho | 1980 |
Metabolic activity of developing rat lung.
Topics: Aging; Animals; Animals, Newborn; Choline; Female; Glucosamine; Glycoproteins; Lung; Palmitic Acids; | 1981 |
Effect of tallow and choline chloride addition to the diet of sows milk composition, milk yield and preweaning pig performance.
Topics: Animals; Animals, Suckling; Body Weight; Choline; Colostrum; Dietary Fats; Fats; Female; Lactation; | 1982 |
The effect of choline acetyltransferase inhibition on acetylcholine synthesis and release in term human placenta.
Topics: Acetylcholine; Aminoisobutyric Acids; Biological Transport; Choline; Choline O-Acetyltransferase; Fe | 1982 |
Effect of early inorganic lead exposure on rat blood-brain barrier permeability to tyrosine or choline.
Topics: Animals; Animals, Suckling; Biological Transport, Active; Blood-Brain Barrier; Choline; Female; Lead | 1982 |
[Personal experience in the treatment of placental insufficiency with cytidine diphosphocholine].
Topics: Adult; Choline; Cytidine Diphosphate Choline; Estriol; Female; Humans; Placenta Diseases; Placental | 1980 |
[Enzymatic lecithin determination in amniotic fluid for antepartal diagnosis of lung maturity - a multi-center study (author's transl)].
Topics: Amniotic Fluid; Choline; Female; Fetal Organ Maturity; Humans; Lung; Phosphatidylcholines; Pregnancy | 1982 |
Hormonal induction of pulmonary maturation in the rabbit fetus: effects of maternal treatment with estradiol-17 beta on th endogenous levels of cholinephosphate, CDP-choline and phosphatidylcholine.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Estradiol; Female; Fetus; Lung; Maternal-Fetal Excha | 1981 |
The influence of sow dietary lipids and choline on piglet survival, milk and carcass composition.
Topics: Animals; Choline; Colostrum; Diet; Dietary Fats; Female; Milk; Pregnancy; Swine | 1981 |
Pool sizes of the precursors for phosphatidylcholine synthesis in developing rat lung.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Fatty Acids; Female; Fetus; Glycerol; Lung; Palmitic | 1981 |
Increased synthesis of phosphatidylcholine by rat lung following premature birth.
Topics: Animals; Choline; Dexamethasone; Female; Gestational Age; Glucose; Lung; Maternal-Fetal Exchange; Ph | 1980 |
Phospholipid synthesis in lung slices from fetuses of alloxan diabetic rabbits.
Topics: Animals; Choline; Diabetes Mellitus, Experimental; Female; Fetus; In Vitro Techniques; Lung; Phospha | 1980 |
Acetylcholine in human placenta. Identification by pyrolysis gas chromatography/mass spectrometry and tissue levels following different modes of delivery.
Topics: Acetylcholine; Cesarean Section; Choline; Delivery, Obstetric; Extraembryonic Membranes; Female; Gas | 1980 |
Elevated choline concentration in neonatal plasma.
Topics: Animals; Animals, Newborn; Choline; Diet; Female; Fetus; Gestational Age; Humans; Infant, Newborn; P | 1980 |
Changes in renal haemodynamics and kidney weight during pregnancy in the unanaesthetized rat.
Topics: Animals; Choline; Female; Glomerular Filtration Rate; Kidney; Organ Size; Phospholipids; Pregnancy; | 1980 |
Evidence for stimulation of glycerophospholipid synthesis in cultured human cells infected with measles virus.
Topics: Amnion; Cell Line; Cell Transformation, Viral; Choline; Female; Humans; Kinetics; Measles virus; Pho | 1980 |
Human amniotic fluid contains fibroblast-pneumonocyte factor.
Topics: Amniotic Fluid; Cells, Cultured; Choline; Female; Fetus; Fibroblast Growth Factors; Gestational Age; | 1980 |
Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet.
Topics: Administration, Oral; Animals; Betaine; Brain; Carbon Radioisotopes; Choline; Chromatography, High P | 1995 |
Isolation of syncytial microvillous membrane vesicles from human term placenta and their application in drug-nutrient interaction studies.
Topics: Alanine; Alkaline Phosphatase; Biological Transport; Calcium; Choline; Female; Food-Drug Interaction | 1995 |
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
Topics: Animals; Betaine; Choline; Choline Deficiency; Female; Lactation; Liver; Male; Maternal-Fetal Exchan | 1995 |
Histochemical demonstration of phospholipid containing choline in the cytoplasm of murine decidual cells.
Topics: Animals; Choline; Cytoplasm; Decidua; Female; Histocytochemistry; Lipid Metabolism; Mice; Mice, Inbr | 1994 |
Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcholinesterase; Ammonia; Animals; Brain; Carnitine; Choline; Choline O-Acetyl | 1995 |
GM1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Choline; Dopamine; Female; G(M1) Ganglioside; Hypo | 1994 |
Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Choline; Diglycerides; Female; Methionine; Microsomes, | 1994 |
Retinoids control surfactant phospholipid biosynthesis in fetal rat lung.
Topics: Acetates; Acyclic Monoterpenes; Animals; Cells, Cultured; Choline; Female; Fetus; Lipid Metabolism; | 1994 |
Morphological assessment of ethyl choline mustard aziridinium-induced neurotoxicity in rat brain reaggregate cultures.
Topics: Animals; Aziridines; Brain; Cells, Cultured; Choline; Female; Microscopy, Electron; Nervous System D | 1993 |
Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy.
Topics: Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Female; Gestational Age; Humans; | 1993 |
Metabolic profiling of amniotic fluid by proton nuclear magnetic resonance spectroscopy: correlation with fetal maturation and other clinical variables.
Topics: Amino Acids; Amniotic Fluid; Choline; Creatinine; Down Syndrome; Embryonic and Fetal Development; Fe | 1994 |
Relationship between thyroid hormone transport and neutral amino acid transport in JAR human choriocarcinoma cells.
Topics: Amino Acids; Biological Transport; Cell Line; Choline; Choriocarcinoma; Female; Humans; Hydrogen-Ion | 1994 |
Valproate and sodium currents in cultured hippocampal neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Choline; Electrophysiology; Female; Hippocampus; Membra | 1993 |
The cation receptor subsite of the choline transporter in preimplantation mouse conceptuses resembles a cation receptor subsite of several amino acid transporters.
Topics: Amino Acid Transport Systems; Animals; Binding Sites; Blastocyst; Carrier Proteins; Cations; Choline | 1993 |
Phospholipid and phospholipid fatty acid composition of mixed murine spinal cord neuronal cultures.
Topics: Animals; Cells, Cultured; Choline; Chromatography, High Pressure Liquid; Ethanolamines; Fatty Acids; | 1993 |
CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides.
Topics: Animals; Bombesin; Cell Division; Choline; Dipeptides; DNA; DNA Replication; Female; Fetus; Kinetics | 1993 |
Inhibition of choline uptake in syncytial microvillus membrane vesicles of human term placenta. Specificity and nature of interaction.
Topics: Atropine; Carrier Proteins; Choline; Cholinergic Antagonists; Cimetidine; Dose-Response Relationship | 1995 |
Alterations in hippocampal hemicholinium-3 binding and related behavioural and biochemical changes after prenatal phenobarbitone exposure.
Topics: Animals; Behavior, Animal; Choline; Female; Hippocampus; Male; Maze Learning; Mice; Phenobarbital; P | 1995 |
Influence of organic cations on basic amino-acid uptake by human placental villi.
Topics: Amino Acids; Arginine; Cations; Choline; Chorionic Villi; Female; Humans; Lithium; Lysine; Pregnancy | 1995 |
The choline content of human breast milk expressed during the first few weeks of lactation.
Topics: Choline; Female; Glycerylphosphorylcholine; Humans; Infant Nutritional Physiological Phenomena; Infa | 1996 |
Dietary choline supplementation in pregnant rats increases hippocampal phospholipase D activity of the offspring.
Topics: Animals; Choline; Female; Food, Fortified; Glutamic Acid; Glycerol; Hippocampus; Oleic Acid; Phospha | 1996 |
Expression of the cholinergic signal-transduction pathway components during embryonic rat heart development.
Topics: Acetylcholinesterase; Animals; Base Sequence; Choline; Choline O-Acetyltransferase; DNA Primers; Fem | 1997 |
Phospholipid containing choline histochemistry of mouse uterine epithelia during preimplantation stage.
Topics: Animals; Azo Compounds; Choline; Embryonic Development; Epithelium; Female; Lipids; Mice; Naphthalen | 1997 |
MR imaging, MR angiography, and MR spectroscopy of the brain in eclampsia.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Edema; Brain Ischemia; Cerebral Arteries; Choline; Cr | 1997 |
Prenatal availability of choline modifies development of the hippocampal cholinergic system.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Biological Availability; Choline; Female; Hippocampus; | 1998 |
Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats.
Topics: Animals; Choline; Choline Deficiency; Dietary Supplements; Female; Hippocampus; In Vitro Techniques; | 1998 |
Decreased serum choline concentrations in humans after surgery, childbirth, and traumatic head injury.
Topics: Anesthesia, General; Cesarean Section; Choline; Choline Deficiency; Craniocerebral Trauma; Elective | 1998 |
Choline availability modulates the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain.
Topics: Aging; Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Biomarkers; Brain; Choline; | 1998 |
Pregnancy-associated adaptations to hepatic phosphatidylcholine biosynthesis in the guinea-pig.
Topics: Adaptation, Physiological; Animals; Choline; Chromatography, High Pressure Liquid; Female; Guinea Pi | 1998 |
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements | 1998 |
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements | 1998 |
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements | 1998 |
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements | 1998 |
Choline, a vital amine.
Topics: Acetylcholine; Aging; Animals; Apoptosis; Brain; Cell Division; Choline; Choline Deficiency; Cogniti | 1998 |
Choline availability alters embryonic development of the hippocampus and septum in the rat.
Topics: Animals; Antimetabolites; Apoptosis; Biomarkers; Brain Chemistry; Bromodeoxyuridine; Cell Differenti | 1999 |
Effect of acute glucose depletion following glucose excess on surfactant phospholipid synthesis in developing fetal lung.
Topics: Animals; Choline; Down-Regulation; Embryonic and Fetal Development; Female; Glucose; Insulin; Lung; | 1999 |
Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus.
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Choline; Choline Deficiency; Corpus Striatum | 1999 |
The effects of neonatal choline dietary supplementation on adult spatial and configural learning and memory in rats.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Choline; Discrimination Learning; Female; Injections, | 1999 |
Culture of one-cell hamster embryos with water soluble vitamins: pantothenate stimulates blastocyst production.
Topics: Animals; Blastocyst; Choline; Cricetinae; Culture Media; Culture Techniques; Dose-Response Relations | 2000 |
Choline supplementation during prenatal development reduces proactive interference in spatial memory.
Topics: Animals; Choice Behavior; Choline; Embryonic and Fetal Development; Female; Fetus; Male; Maze Learni | 1999 |
Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.
Topics: Aging; Animals; Animals, Newborn; Choline; Electric Stimulation; Female; Fetus; Hippocampus; In Vitr | 1999 |
Perinatal complications and abnormal proton metabolite concentrations in frontal cortex of adolescents seen on magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain Damage, Chronic; Choline; Creatine; Female; Follow-Up Studies; Frontal Lobe; Hu | 2000 |
Post-natal modulation of heart and liver phosphoglyceride fatty acids in pups.
Topics: Animal Feed; Animals; Animals, Newborn; Animals, Suckling; Body Weight; Choline; Diet; Ethanolamines | 1999 |
Choline plus cytidine stimulate phospholipid production, and the expression and secretion of amyloid precursor protein in rat PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Membrane; Choline; Cytidine; Female | 2000 |
Na(+)-K(+)-ATPase is distributed to microvillous and basal membrane of the syncytiotrophoblast in human placenta.
Topics: Animals; Binding, Competitive; Cell Membrane; Choline; Duodenum; Female; Humans; Immune Sera; Immuno | 2000 |
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cerebral Cortex; Choline; Choline O-Acetyltran | 2000 |
Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood.
Topics: Animals; Carbachol; Choline; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Hippocam | 2000 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Electric Stimulation; Excitatory Postsynaptic Pot | 2000 |
Impact of dietary rumen undegradable protein and rumen-protected choline on intake, peripartum liver triacylglyceride, plasma metabolites and milk production in transition dairy cows.
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Urea Nitrogen; Body Weight; Cattle; Choli | 2000 |
Ethanolamine transport in human placental brush-border membrane vesicles.
Topics: Adult; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Choline; Diffusion; Ethano | 2001 |
Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Dyskinesia Agents; Choline; Deanol; Embryo, Mammalian; Em | 2001 |
Choline deficiency induces apoptosis in primary cultures of fetal neurons.
Topics: Animals; Apoptosis; Cell Membrane; Cells, Cultured; Ceramides; Cerebral Cortex; Choline; Choline Def | 2001 |
Three-dimensional proton MR spectroscopic imaging of premature and term neonates.
Topics: Aspartic Acid; Brain; Brain Mapping; Cerebral Hemorrhage; Choline; Chorioamnionitis; Creatine; Energ | 2001 |
Regulation of glutamate transport and transport proteins in a placental cell line.
Topics: Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; ATP-Binding Cassette Transpor | 2001 |
Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus.
Topics: Animal Nutritional Physiological Phenomena; Animals; Cell Cycle Proteins; Choline; Cyclin-Dependent | 2001 |
The transfer of choline from the host to the bacterial cell surface requires glpQ in Haemophilus influenzae.
Topics: Adult; Animals; Bacterial Proteins; Choline; Female; Glycerylphosphorylcholine; Haemophilus Infectio | 2001 |
Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung.
Topics: Animals; Choline; Female; Gene Expression Regulation, Developmental; Intercellular Signaling Peptide | 2001 |
Prenatal choline supplementation protects against postnatal neurotoxicity.
Topics: Aging; Animals; Cell Count; Choline; Cytoprotection; Dietary Supplements; Dizocilpine Maleate; Excit | 2002 |
Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.
Topics: Animals; Choline; Choline Deficiency; Dietary Supplements; Female; Hippocampus; Male; Maze Learning; | 2002 |
Perinatal choline treatment modifies the effects of a visuo-spatial attractive cue upon spatial memory in naive adult rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Brain; Brain Chemistry; Choline; Choline O-Acetyltransfera | 2002 |
Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
Topics: Adult; Aspartic Acid; Brain Diseases; Choline; Confusion; Creatine; Female; Headache; Humans; Magnet | 2002 |
Tetrahydrocannabinol (THC) alters synthesis and release of surfactant-related material in isolated fetal rabbit type II cells.
Topics: Animals; Cell Survival; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Dose-Respo | 2002 |
1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Choline; Citric Acid; Creatinine; Energy Metabolism; Femal | 2002 |
Lung lecithin biosynthesis in the nonhuman primate fetus: determination of the primary pathway in vivo.
Topics: Acid-Base Equilibrium; Animals; Choline; Ethanolamines; Female; Fetus; Haplorhini; Hydrogen-Ion Conc | 1976 |
Effects of drugs on the uptake of acetylcholine by human term placenta fragments.
Topics: Acetylcholine; Anesthetics, Local; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biologica | 1976 |
Choline acetyltransferase and carnitine acetyltransferase in the placenta of the mouse.
Topics: Acetates; Acetyl Coenzyme A; Acetylcholine; Acetyltransferases; Animals; Carnitine; Carnitine O-Acet | 1977 |
Developmental changes in the brain levels of neurotransmitters as influenced by maternal ethanol consumption in the rat.
Topics: 4-Aminobutyrate Transaminase; Acetaldehyde; Acetylcholine; Alcoholism; Animals; Animals, Newborn; Br | 1977 |
[Study of fetal alveolar surfactant: possibility of induction].
Topics: Adrenergic beta-Agonists; Adult; Choline; Cytidine Diphosphate Choline; Female; Fetus; Glucocorticoi | 1979 |
Prenatal diagnosis of Niemann-Pick disease type A using chromogenic substrate.
Topics: Amniotic Fluid; Choline; Female; Fibroblasts; Humans; Niemann-Pick Diseases; Phosphorylcholine; Preg | 1977 |
Lung lecithin synthesis in primates as related to respiratory distress syndrome.
Topics: Amniotic Fluid; Animals; Choline; Ethanolamines; Female; Fetus; Gestational Age; Haplorhini; Humans; | 1978 |
Phospholipid biosynthesis: the activity of phosphatidic acid phosphohydrolase in the developing lung and amnionic fluid.
Topics: Amniotic Fluid; Animals; Choline; Female; Fetus; Gestational Age; Humans; Liver; Lung; Microsomes; P | 1975 |
Role of adenosine 3', 5'-monophosphate in maturation of fetal lungs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Animals; Choline; Cyclic AMP; Female; Hydrocorti | 1976 |
Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture.
Topics: Aminophylline; Animals; Bucladesine; Choline; Choline Kinase; Diacylglycerol Cholinephosphotransfera | 1977 |
Corticosteroid induction of phosphatidic acid phosphatase in fetal rabbit lung.
Topics: Animals; Betamethasone; Choline; Diacylglycerol Cholinephosphotransferase; Enzyme Induction; Female; | 1977 |
Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Betamethasone; Choline; Choline Kinase; Diac | 1979 |
Effects of dexamethasone of neurotransmitter enzymes in chromaffin tissue of the newborn rat.
Topics: Acetyltransferases; Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Aorta; Basal Gangli | 1975 |
In vitro perfusion studies of the human placenta. VI. Evidence against active glucose transport.
Topics: Adult; Biological Transport, Active; Chlorides; Choline; Dinitrophenols; Female; Glucose; Humans; In | 1979 |
The influence of hormones on the biochemical development of fetal rat lung in organ culture. I. Estrogen.
Topics: Acetates; Animals; Choline; Estradiol; Female; Glycogen; Lung; Organ Culture Techniques; Phosphatidy | 1979 |
Fate of labeled choline administered intraruminally to pregnant ewes given manganese-deficient or -supplemented rations.
Topics: Animal Feed; Animals; Choline; Fatty Acids; Female; Manganese; Pregnancy; Pregnancy, Animal; Rumen; | 1979 |
[Regarding the effect of bromhexine metabolite VII on lecithin synthesis in fetal lungs (author's transl)].
Topics: Ambroxol; Animals; Bromhexine; Choline; Female; In Vitro Techniques; Lung; Pregnancy; Pulmonary Surf | 1977 |
[Increased production of alveolar surfactant in the human fetus after treatment with cytidine diphosphocholine].
Topics: Adult; Amniotic Fluid; Choline; Cytidine Diphosphate Choline; Female; Fetus; Humans; Phosphatidylcho | 1977 |
Effects of N-methylaminoethanol, and N,N-dimethylaminoethanol in the diet of pregnant rats on neonatal rat brain cholinergic and phospholipid profile.
Topics: Acetylcholine; Animals; Animals, Newborn; Body Weight; Brain; Choline; Deanol; Ethanolamines; Female | 1978 |
Pulmonary phospholipid biosynthesis and the ability of the fetal rabbit lung to reduce cortisone to cortisol during the final ten days of gestation.
Topics: Animals; Choline; Cortisone; Female; Fetus; Gestational Age; Hydrocortisone; In Vitro Techniques; Lu | 1978 |
Labeling of phosphatidylcholine in the alveolar wash of rabbits in utero.
Topics: Animals; Choline; Female; Isotope Labeling; Models, Biological; Palmitic Acids; Phosphates; Phosphat | 1978 |
Choline metabolism in human term placenta--studies on de novo synthesis and the effects of some drugs on the metabolic fate of [N-methyl 3H]choline.
Topics: Choline; Dinitrophenols; Female; Humans; In Vitro Techniques; Paraoxon; Placenta; Pregnancy; Sodium; | 1978 |
Enzymic assay for lecithin in amniotic fluid.
Topics: Alcohol Oxidoreductases; Amniotic Fluid; Arthrobacter; Bilirubin; Blood; Choline; Female; Humans; Ph | 1979 |
[The place of citicolin in pulmonological therapy (author's transl)].
Topics: Animals; Choline; Cytidine Diphosphate Choline; Female; Humans; Infant, Newborn; Lipids; Lung; Mater | 1976 |
[Methionine adenosyltransferase and transmethylation in fetal and neonatal lung of the human, monkey, and rabbit (author's transl)].
Topics: Animals; Animals, Newborn; Choline; Cortisone; Female; Gestational Age; Haplorhini; Humans; Infant, | 1976 |
Fetal lung lecithin metabolism and the amniotic fluid L/S ratio in rhesus monkey gestations.
Topics: Amniotic Fluid; Animals; Choline; Female; Fetus; Gestational Age; Haplorhini; Lung; Macaca mulatta; | 1976 |
Re-evaluation of the kinetic mechanism of the choline acetyltransferase reaction.
Topics: Acetyltransferases; Choline; Choline O-Acetyltransferase; Ethanolamines; Female; Humans; Kinetics; M | 1977 |
Lack of influence of the phase of estrus cycle or treatment with steroid contraceptive drugs on cholinergic parameters in mouse and rat brain.
Topics: Acetylcholine; Acetyltransferases; Animals; Brain; Choline; Choline O-Acetyltransferase; Diencephalo | 1976 |
[In vivo and in vitro investigations of the effect of decortilen (16-methylenprednisolone) on lecithin synthesis in the fetal lung (author's transl)].
Topics: Animals; Choline; Female; Humans; Hyaline Membrane Disease; In Vitro Techniques; Infant, Newborn; Lu | 1976 |
[Experimental investigations in regard to the optimal stimulation of lecithin synthesis in the fetal lung via glucocorticoids (author's transl)].
Topics: Animals; Choline; Dexamethasone; Dose-Response Relationship, Drug; Female; Glucocorticoids; Hydrocor | 1976 |
Choline and acetylcholine in rats: effect of dietary choline.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Choline; Choline Deficiency; Deanol; Diet; Duodenum; | 1976 |
[Role of Ca ions in the activity of mammary gland secretory cells].
Topics: Acetylcholine; Animals; Biological Transport; Calcium; Caseins; Choline; Female; Goats; Lactation; M | 1976 |
The use of monolayer cell cultures in the study of fetal and neonatal pulmonary cell growth and lecithin synthesis.
Topics: Animals; Animals, Newborn; Cells, Cultured; Choline; Female; Fetus; Growth; Hydrocortisone; Lung; Me | 1975 |
Choline acetyltransferase and acetylcholinesterase in the developing rat spinal cord.
Topics: Acetylcholinesterase; Acetyltransferases; Age Factors; Animals; Animals, Newborn; Carbon Radioisotop | 1975 |
The rabbit fetal lung as a glucocorticoid target tissue.
Topics: Aldosterone; Animals; Cells, Cultured; Choline; Corticosterone; Cortisone; Dexamethasone; Estradiol; | 1975 |
The choline incorporation pathway: primary mechanism for de novo lecithin synthesis in fetal primate lung.
Topics: Adenosine Triphosphate; Amniotic Fluid; Animals; Animals, Newborn; Choline; Female; Gestational Age; | 1975 |
Effects of cortisol on serially propogated fibroblast cell cultures derived from the rabbit retal lung and skin.
Topics: Animals; Biotransformation; Cells, Cultured; Choline; Cortisone; Culture Media; Female; Fetus; Fibro | 1975 |
Stimualtion of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration.
Topics: Animals; Choline; Cytidine Diphosphate Diglycerides; Enzyme Activation; Female; Gestational Age; Gly | 1975 |
Studies on accumulation and metabolic fate of (N-Me3h)choline in human term placenta fragments.
Topics: Binding Sites; Binding, Competitive; Biological Transport, Active; Cations, Monovalent; Choline; Cya | 1976 |
Effect of supplemental choline on reproductive performance of sows: a cooperative regional study.
Topics: Animals; Animals, Newborn; Birth Weight; Choline; Female; Muscular Diseases; Nutritional Requirement | 1976 |
Comparison of effects of epidermal and insulin-like growth factors, gastrin releasing peptide and retinoic acid on fetal lung cell growth and maturation in vitro.
Topics: Animals; Cell Division; Choline; DNA; Epidermal Growth Factor; Epithelium; Female; Fibroblasts; Fluo | 1992 |
Effects of betamethasone and thyroid hormone on fetal rat lung maturation in vivo.
Topics: Animals; Betamethasone; Choline; Drug Synergism; Embryonic and Fetal Development; Female; Injections | 1992 |
Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A.
Topics: Analysis of Variance; Animals; Aziridines; Cerebral Ventricles; Choline; Cognition; Female; Fetal Ti | 1992 |
GTP-related effects and binding by differentiating fetal rabbit type II alveolar cells in vitro.
Topics: Animals; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Choline; Ethidium; Femal | 1992 |
Culture of fetal alveolar epithelial type II cells in serum-free medium.
Topics: Animals; Biotin; Cell Division; Cells, Cultured; Choline; Culture Media, Serum-Free; DNA; Epithelial | 1991 |
The histopathological, behavioral and neurochemical effects of intraventricular injection of ethylcholine mustard aziridinium (AF64A) in the neonatal rat.
Topics: Animals; Animals, Newborn; Autonomic Nervous System Diseases; Aziridines; Behavior, Animal; Biogenic | 1991 |
Choline-induced spatial memory facilitation correlates with altered distribution and morphology of septal neurons.
Topics: Animals; Choline; Female; Male; Maternal-Fetal Exchange; Memory; Neurons; Pregnancy; Prosencephalon; | 1991 |
Rapid and sensitive discriminating determination of acetylcholinesterase activity in amniotic fluid with a choline sensor.
Topics: Acetylcholine; Acetylcholinesterase; Alcohol Oxidoreductases; Amniotic Fluid; Butyrylcholinesterase; | 1991 |
Origin and significance of acetylcholine and choline in plasma and serum from normal and paretic cows.
Topics: Acetylcholine; Animals; Cattle; Cattle Diseases; Choline; Female; Gas Chromatography-Mass Spectromet | 1991 |
Inhibitor action on placental calcium transport.
Topics: Adenosine Triphosphatases; Biological Transport; Calcium; Calcium Radioisotopes; Carrier Proteins; C | 1991 |
Intrahippocampal transplants of septal cholinergic neurons: high-affinity choline uptake and spatial memory function.
Topics: Animals; Brain Tissue Transplantation; Choline; Female; Fetal Tissue Transplantation; Learning; Male | 1991 |
Sodium-dependent magnesium transport across in situ perfused rat placenta.
Topics: Acetazolamide; Amiloride; Animals; Biological Transport; Calcium; Choline; Edetic Acid; Female; Magn | 1991 |
Glycine uptake in pre-implantation mouse embryos: kinetics and the effects of external [Na+].
Topics: Animals; Blastocyst; Chlorides; Choline; Dose-Response Relationship, Drug; Embryonic Development; Fe | 1990 |
Global in vivo replacement of choline by N-aminodeanol. Testing a hypothesis about progressive degenerative dementia: I. Dynamics of choline replacement.
Topics: Acetylation; Acetylcholinesterase; Alzheimer Disease; Animals; Brain Chemistry; Butyrylcholinesteras | 1990 |
Global in vivo replacement of choline by N-aminodeanol. Testing a hypothesis about progressive degenerative dementia: II. Physiological and behavioral effects.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Body Weight; Bra | 1990 |
Determination of succinylcholine hydrolytic enzyme activity in human plasma.
Topics: Acetylcholine; Adult; Aged; Butyrylcholinesterase; Choline; Chromatography, Liquid; Female; Humans; | 1990 |
Effect of prenatal exposure to phencyclidine on the postnatal development of the cholinergic system in the rat.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Choline; Cholinergic Fibers; Corpus Striatum; Drug T | 1990 |
Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain.
Topics: Animals; Brain; Choline; Choline O-Acetyltransferase; Female; Fetus; Growth; Nicotine; Parasympathet | 1989 |
Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both.
Topics: Age Factors; Animals; Brain; Choline; Choline O-Acetyltransferase; Discrimination Learning; Female; | 1989 |
Inositol and choline levels in the diet and neutral lipid hepatic content of lactating rat.
Topics: Animals; Body Weight; Choline; Dietary Proteins; Female; Inositol; Lactation; Lipoproteins; Liver; O | 1989 |
Stimulation of phospholipid hydrolysis and arachidonic acid mobilization in human uterine decidua cells by phorbol ester.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Choline; Decidua; Female; Humans; Hydrolysis; | 1987 |
Contractile properties of chemically skinned fibers from pregnant rat myometrium: existence of an internal Ca-store.
Topics: Animals; Calcimycin; Calcium; Cations, Divalent; Choline; Cyclic AMP; Female; Inositol 1,4,5-Trispho | 1988 |
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus | 1985 |
Effects of dietary and abomasally infused choline on milk production responses of lactating dairy cows.
Topics: Abomasum; Animals; Cattle; Choline; Diet; Dietary Fats; Eating; Female; Intubation, Gastrointestinal | 1989 |
Regulation of phospholipid synthesis by intracellular phospholipases in fetal rabbit type II pneumocytes.
Topics: Acetophenones; Animals; Choline; Choline-Phosphate Cytidylyltransferase; Female; Lung; Nucleotidyltr | 1985 |
Changes in membrane permeability in cells infected by human cytomegalovirus.
Topics: Biological Transport; Cell Membrane Permeability; Cell Transformation, Viral; Choline; Cytomegalovir | 1986 |
Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells.
Topics: Animals; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Dexamethasone; Enzyme Ind | 1987 |
Behavioral differences in the developing rat following postnatal anoxia or postnatally injected AF-64A, a cholinergic neurotoxin.
Topics: Animals; Avoidance Learning; Aziridines; Azirines; Behavior, Animal; Brain; Choline; Female; Fetal H | 1988 |
[Lipid metabolism in the gastrointestinal tract of lactating cows during the duodenal infusion of choline chloride and methionine].
Topics: Animal Feed; Animals; Bile; Cattle; Choline; Digestive System; Duodenum; Female; Gastrointestinal Co | 1988 |
Rat and human mammary tissue can synthesize choline moiety via the methylation of phosphatidylethanolamine.
Topics: Animals; Breast; Choline; Female; Humans; Lactation; Mammary Glands, Animal; Methylation; Methyltran | 1988 |
A rapid electrochemical assay of lecithin in amniotic fluid using a fluoride ion-sensitive electrode.
Topics: Amniotic Fluid; Animals; Choline; Electrodes; Female; Fluorides; Gestational Age; Humans; Ions; Meth | 1988 |
Dietary choline effects on milk yield and duodenal choline flow in dairy cattle.
Topics: Animals; Cattle; Choline; Digestion; Duodenum; Female; Fermentation; Lactation; Male; Pregnancy; Rum | 1988 |
Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory.
Topics: Animals; Choline; Cues; Discrimination Learning; Female; Male; Memory; Mental Recall; Orientation; P | 1988 |
Prenatal caffeine causes long lasting behavioral and neurochemical changes.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain; Caffeine; Cerebral Cortex; Choline; Discrimina | 1988 |
Lactation response to short-term abomasal infusion of choline, inositol, and soy lecithin.
Topics: Abomasum; Animals; Cattle; Choline; Female; Inositol; Lactation; Phosphatidic Acids; Phosphatidylcho | 1987 |
Acetylcholine and choline levels in rabbit fetuses exposed to anticholinergics.
Topics: Acetylcholine; Animals; Choline; Female; Fetal Diseases; Fetus; Gestational Age; Maternal-Fetal Exch | 1987 |
Isolation and characterization of differentiated alveolar type II cells from fetal human lung.
Topics: Acetates; Acetic Acid; Cell Separation; Choline; Dexamethasone; Female; Fluorescent Antibody Techniq | 1986 |
Behavioural changes in adult rats produced by early postnatal maternal deprivation and treatment with choline chloride.
Topics: Acetylcholine; Animals; Animals, Newborn; Behavior, Animal; Brain; Choline; Emotions; Female; Male; | 1986 |
Evidence of saturable uptake mechanisms at maternal and fetal sides of the perfused human placenta by rapid paired-tracer dilution: studies with calcium and choline.
Topics: Biological Transport, Active; Calcium; Choline; Female; Glucose; Humans; Hydrogen-Ion Concentration; | 1986 |
Prenatal monosodium glutamate causes long-lasting cholinergic and adrenergic changes in various brain regions.
Topics: Animals; Brain; Choline; Choline O-Acetyltransferase; Female; Glutamates; Parasympathetic Nervous Sy | 1987 |
Effect of level of protein and supplemental choline on reproductive performance of gilts fed sorghum diets.
Topics: Animal Feed; Animals; Body Weight; Choline; Dietary Proteins; Female; Pregnancy; Pregnancy, Animal; | 1987 |
Membrane carriers and receptors at maternal and fetal sides of the placenta by single circulation paired-tracer dilution: evidence for a choline transport system.
Topics: Animals; Biological Transport; Choline; Female; Guinea Pigs; In Vitro Techniques; Indicator Dilution | 1985 |
Ontogenesis of nicotinic acetylcholine receptors and presynaptic cholinergic neurons in mammalian brain.
Topics: Animals; Brain; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Kinetics; Mollusk | 1986 |
Integrated substrate utilization by perinatal lung.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Choline; Energy Metabolism; Female; Fetus; Glucose | 1986 |
Effect of cortisol on the synthesis of lamellar body glycerophospholipids in fetal rabbit lung tissue in vitro.
Topics: Animals; Choline; Female; Hydrocortisone; Lung; Organ Culture Techniques; Phosphatidic Acids; Phosph | 1985 |
Influence of theophylline on fetal rat lung phosphatidylcholine synthesis in vivo.
Topics: Animals; Choline; Female; Fetus; Injections, Intraperitoneal; Kinetics; Lung; Phosphatidylcholines; | 1985 |
Dihydrotestosterone inhibits fibroblast-pneumonocyte factor-mediated synthesis of saturated phosphatidylcholine by fetal rat lung cells.
Topics: Animals; Cells, Cultured; Choline; Dihydrotestosterone; Female; Fibroblast Growth Factors; Hydrocort | 1985 |
Measurement of free choline concentrations in maternal and neonatal blood by micropyrolysis gas chromatography.
Topics: Choline; Chromatography, Gas; Erythrocytes; Female; Fetal Blood; Humans; Infant, Newborn; Plasma; Pr | 1985 |
Characterization of choline transport at maternal and fetal interfaces of the perfused guinea-pig placenta.
Topics: Animals; Biological Transport; Choline; Ethylmaleimide; Female; Guinea Pigs; Hemicholinium 3; In Vit | 1985 |
Regulation of methyl group metabolism in lactating ewes.
Topics: Animals; Choline; Creatine; Creatinine; Female; Lactation; Liver; Methyltransferases; Milk; Pancreas | 1985 |
The nerves of the umbilical cord in man and the rat.
Topics: Acetylcholinesterase; Animals; Choline; Extraembryonic Membranes; Female; Histocytochemistry; Humans | 1971 |
Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: evidence for involvement of brain dopamine.
Topics: Acetyltransferases; Age Factors; Animals; Appetite; Avoidance Learning; Behavior, Animal; Brain; Bra | 1973 |
Effects of maternal dietary lipotropes on prenatal and neonatal rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Choline; Female; Lipotropic A | 1970 |
Antibodies to rat brain choline acetyltransferase: species and organ specificity.
Topics: Acetyltransferases; Animals; Antibodies; Brain; Carbon Radioisotopes; Carnitine; Cats; Cattle; Choli | 1973 |
Fractionation of Listeria monocytogenes serotype 5.
Topics: Abortion, Induced; Abortion, Veterinary; Agglutination Tests; Ammonium Sulfate; Animals; Antigens, B | 1973 |
The accumulation of malachite green stainable phospholipid in rabbit spermatozoa during maturation in the epididymis, and its possible role in capacitation.
Topics: Animals; Benzylidene Compounds; Choline; Coloring Agents; Epididymis; Estrus; Female; Glutaral; Male | 1974 |
Effects of deficiencies in labile methyl groups on the growth and development of fetal rats.
Topics: Animals; Choline; Congenital Abnormalities; Deficiency Diseases; Diet; Embryonic and Fetal Developme | 1970 |
Proceedings: Penetration of choline through rat placenta in vivo.
Topics: Animals; Brain; Choline; Female; Fetus; Liver; Maternal-Fetal Exchange; Phosphatidylcholines; Placen | 1974 |
Membranes of mammary gland. I. Bovine mammary mitochondria.
Topics: Amino Alcohols; Animals; Cattle; Cell Membrane; Cholesterol; Choline; Cytochromes; Electrophoresis; | 1971 |
Epithelial-mesenchymal interactions during odontogenesis. 3. A simple method for the isolation of matrix vesicles.
Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Amelogenesis; Animals; Choline; C | 1972 |
Sexual differences in the hypothalamic cholinergic system before and after puberty: inductory effect of testosterone.
Topics: Acetylcholine; Acetylcholinesterase; Acetyltransferases; Age Factors; Animals; Cerebral Cortex; Chol | 1973 |
Choline kinase and choline phosphotransferase in developing fetal rat lung.
Topics: Animals; Carbon Radioisotopes; Choline; Cytosine Nucleotides; Female; Fetus; Gestational Age; Lung; | 1974 |
Rapid changes in nucleoside transport induced by growth inhibitors. Studies with neoplastic mast cells.
Topics: Adenosine; Animals; Biological Transport; Bucladesine; Cell Count; Cell Line; Choline; Dose-Response | 1974 |
Secretion rates and chemical composition of oviduct and uterine fluids in sows.
Topics: Amino Acids; Animals; Body Fluids; Chlorides; Choline; Estrus; Female; Glucose; Lactates; Lipids; Ma | 1974 |
Workshop on possible pharmacologic mechanisms for enhancement of lung maturation.
Topics: Adrenocorticotropic Hormone; Choline; Cyclic AMP; Female; Glucocorticoids; Humans; Infant, Newborn; | 1974 |
Membrane proliferation and phosphatidylcholine synthesis in normal, preneoplastic, and neoplastic mammary gland tissues in C3H mice.
Topics: Adenocarcinoma; Animals; Carbon Isotopes; Choline; Cytochrome c Group; DNA; Endoplasmic Reticulum; F | 1972 |
Effects of steroids on the enzymatic pathways of lecithin production in fetal rabbits.
Topics: Adrenal Cortex Hormones; Animals; Body Weight; Choline; DNA; Enzyme Induction; Female; Fetus; Hydroc | 1974 |
Bidrin: perinatal toxicity and effect on the development of brain acetylcholinesterase and choline acetyltransferase in mice.
Topics: Abnormalities, Drug-Induced; Acetylcholinesterase; Acetyltransferases; Analysis of Variance; Animals | 1974 |
Choline requirement of pregnant sows and gilts under restricted feeding conditions.
Topics: Administration, Oral; Animal Feed; Animals; Animals, Newborn; Birth Weight; Body Weight; Choline; Ch | 1974 |
[Effect on the phospholipid contents in the fetal lung of the rabbit determined by administration of citicholine to the mother].
Topics: Animals; Animals, Newborn; Cholesterol; Choline; Creatine Kinase; Cytosine Nucleotides; Female; Fetu | 1974 |
Induction of choline phosphotransferase and lecithin synthesis in the fetal lung by corticosteroids.
Topics: Animals; Carbon Isotopes; Choline; Cycloheximide; Dactinomycin; Enzyme Induction; Female; Fetus; Ges | 1973 |
Effect of dexamethasone on phenylethanolamine N-methyltransferase in chromaffin tissue of the neonatal rat.
Topics: Acetyltransferases; Adrenal Cortex Hormones; Animals; Animals, Newborn; Choline; Chromaffin System; | 1973 |
[Trial of a new drug, citicholine, in the therapy and prevention of eclampsic coma].
Topics: Adult; Choline; Cytosine Nucleotides; Eclampsia; Female; Humans; Pre-Eclampsia; Pregnancy | 1973 |
Biosynthesis of sphingomyelin in developing brain tissues.
Topics: Animals; Brain; Cattle; Ceramides; Chickens; Choline; Cytosine Nucleotides; Female; Hydrogen-Ion Con | 1973 |
[Intensive care of cases of severe eclampsia (author's transl)].
Topics: Acidosis, Respiratory; Adolescent; Adult; Albumins; Carbamates; Choline; Cortisone; Droperidol; Drug | 1973 |
Human placental phospholipid synthesis.
Topics: Carbon Radioisotopes; Choline; Ethanolamines; Female; Glycerides; Glycerol; Humans; Microsomes; Mito | 1973 |
Evaluation of supplemental choline for reproducing sows housed in total confinement on concrete or in dirt lots.
Topics: Animal Feed; Animals; Animals, Newborn; Birth Weight; Choline; Female; Fertilization; Glycine max; H | 1973 |
Choline acetyltransferase of human placenta during the first trimester of pregnancy.
Topics: Acetylcholine; Acetyltransferases; Bromine; Carbon Radioisotopes; Chlorine; Choline; Cholinesterase | 1974 |
Skeletal muscle lipids. 3. Changes in fatty acid composition of individual phosphoglycerides in man from fetal to middle age.
Topics: Adolescent; Adult; Aging; Cardiolipins; Child; Child, Preschool; Choline; Chromatography, Gas; Chrom | 1974 |
UDP-galactose:glycoprotein galactosyltransferase activity in tissues of developing rat.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Choline; Cyto | 1974 |
Kinetic mechanisms of human placental choline acetyltransferase.
Topics: Acetylcholine; Acyltransferases; Carbon Isotopes; Choline; Coenzyme A; Female; Humans; Kinetics; Pla | 1972 |
Subtle consequences of methylmercury exposure: behavioral deviations in offspring of treated mothers.
Topics: Acyltransferases; Animals; Behavior, Animal; Brain; Brain Chemistry; Choline; Cholinesterases; Defec | 1972 |
[Effect of CDP-choline on phospholipid production in the fetal lung of the rabbit].
Topics: Animals; Choline; Cytosine Nucleotides; Female; Fetus; Lung; Phosphatidylcholines; Phosphatidylethan | 1972 |
Secretion rates and chemical composition of oviduct and uterine fluids in rabbits.
Topics: Aldehydes; Amino Acids; Animals; Body Fluids; Choline; Cholinesterases; Citrates; Electrolytes; Este | 1971 |
Activity of choline acetyltransferase in various human adult and fetal tissues.
Topics: Acetylcholine; Acyltransferases; Adult; Aged; Basal Ganglia; Brain; Carbon Isotopes; Cerebellum; Cer | 1971 |
Hypertension in young rats following choline deficiency in maternal diets.
Topics: Age Factors; Aging; Animals; Blood Pressure Determination; Choline; Choline Deficiency; Female; Feta | 1971 |
Human placental choline acetyltransferase. Radiometric assay, inhibition by analogues of choline and acetylcholine, and isotopic exchange between choline and acetylcholine.
Topics: Acetamides; Acetates; Acetylcholine; Acyltransferases; Binding Sites; Biological Assay; Carbon Isoto | 1971 |
Effect of removing the external sodium on the electrical and mechanical activities of the pregnant mouse myometrium.
Topics: Action Potentials; Animals; Calcium; Choline; Female; Hypertonic Solutions; Isotonic Solutions; Lith | 1971 |
Increased incorporation of methyl-14C-choline, methyl-14C-methionine and 1,2-14C-ethanolamine into phospholipids by liver slices from pregnant rats.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Choline; Chromatography, Paper; Female; In Vitro Technique | 1969 |
Phospholipids and the onset of labor in rabbits.
Topics: Abortion, Induced; Animals; Biological Assay; Choline; Chromatography, Thin Layer; Fatty Acids; Fema | 1970 |
Biosynthesis of phosphatidyl choline during prenatal development of the rat lung.
Topics: Animals; Carbon Isotopes; Choline; Chromatography, Paper; Female; Lung; Male; Methionine; Phosphatid | 1968 |
Phospholipid metabolism in the developing liver. I. The biosynthesis of choline glycerophosphatides by liver slices from fetal, newborn and adult rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Choline; Chromatography, Thin Layer; Female; Fetu | 1969 |
Livers of choline-deficient pregnant and fetal rats.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Fatty Liver; Female; Fetus; Liver; Pregna | 1965 |