choline has been researched along with Parkinson Disease in 61 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pergolide was administered up to a dose of 1 mg t." | 2.73 | Influences of dopaminergic treatment on motor cortex in Parkinson disease: a MRI/MRS study. ( Berti, C; Bianchi, MC; Bonuccelli, U; Ceravolo, R; Del Dotto, P; Gambaccini, G; Logi, C; Lucetti, C; Murri, L; Rossi, G; Tosetti, M, 2007) |
| "Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study." | 2.71 | MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms. ( Liu, Y; Ruan, LX; Shang, DS; Yuan, M; Zhang, LJ; Zheng, XN; Zhu, XC, 2004) |
| "Thirty patients with Parkinson's disease, treated with levodopa for the past few years, concomitantly received 500 mg of cytidine diphosphate choline (CDPC) daily for 30 days." | 2.66 | Clinical trial on the use of cytidine diphosphate choline in Parkinson's disease. ( Cubells, JM; Hernando, C, 1988) |
| "myo-Inositol was raised by about 15%, again uniformly throughout the brain, but there was no evidence for changed levels of choline." | 2.41 | A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. ( Firbank, MJ; Harrison, RM; O'Brien, JT, 2002) |
| "There are several reports of MRS in Parkinson's disease(PD) and multiple system atrophy(MSA)." | 2.40 | [Magnetic resonance spectroscopy in Parkinson's disease and multiple system atrophy]. ( Aotsuka, A; Hattori, T; Shinotoh, H, 1997) |
| "21 patients with Parkinson's disease and 24 controls were examined using magnetic resonance spectroscopic imaging at 3 Tesla." | 1.40 | Dopamine reduction in the substantia nigra of Parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. ( Gröger, A; Klose, U; Kolb, R; Schäfer, R, 2014) |
| "The mild cognitive impairment in Parkinson's disease (PD-MCI) has received increasing attention, of which the diagnosis is challenging." | 1.39 | Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment. ( Gan, R; Huang, B; Huang, Z; Nie, K; Wang, L; Zhang, Y; Zhao, J, 2013) |
| "Nine patients with Parkinson's disease and eight age- and gender-matched healthy controls were included in this study." | 1.37 | Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's disease. ( Berg, D; Chadzynski, G; Godau, J; Gröger, A; Klose, U, 2011) |
| "Although motor symptoms of Parkinson's disease (PD) are initially responsive to dopamine replacement therapy, nonresponsive features develop over time, suggesting that impaired dopaminergic function alone may not be wholly responsible for all the motor features of the disease." | 1.35 | Intact presupplementary motor area function in early, untreated Parkinson's disease. ( Camicioli, RM; Gee, M; Hanstock, CC; Martin, WR; Wieler, M, 2008) |
| "Although no difference was found between groups with RBD and IPD without dream enactment behavior in demographic characteristics, duration of disease, mean levodopa dosage and duration of levodopa use, all UPDRS scores (total, motor and cognitive) were worse in RBD group (p<0." | 1.33 | Brainstem 1H-MR spectroscopy in patients with Parkinson's disease with REM sleep behavior disorder and IPD patients without dream enactment behavior. ( Dincer, A; Hanoglu, L; Meral, H; Ozer, F, 2006) |
| "The basis for cognitive deficits in Parkinson's disease (PD) is unknown." | 1.32 | Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia. ( Bastos, AC; Camicioli, RM; Emery, DJ; Fisher, NJ; Foster, SL; Hanstock, CC; Korzan, JR, 2004) |
| "The level in patients with Parkinson's disease, where dementia develops in up to 40% of patients, was not elevated significantly compared to that in controls." | 1.32 | Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor. ( Aasly, J; Gårseth, M; Sonnewald, U; White, LR, 2004) |
| "Six patients with idiopathic Parkinson's disease (IPD), six with clinically probable multiple system atrophy and six control subjects underwent quantitative proton magnetic resonance spectroscopy (MRS)." | 1.31 | Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy. ( Clarke, CE; Lowry, M, 2000) |
| "The study included 12 patients with progressive supranuclear palsy, 10 with Parkinson's disease, nine with corticobasal degeneration and 11 age-matched normal control subjects." | 1.30 | Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. ( Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G, 1997) |
| "Choline levels were significantly lower in untreated and treated patients compared to control subjects (p = 0." | 1.28 | Cerebrospinal fluid choline levels are decreased in Parkinson's disease. ( Colliver, JA; Giacobini, E; Manyam, BV, 1990) |
| "CDP-choline treatment showed a significant improvement of rigidity and bradykinesia and a less important amelioration of tremor." | 1.26 | New strategies in the management of Parkinson's disease: a biological approach using a phospholipid precursor (CDP-choline). ( Agnoli, A; Bruno, G; Denaro, A; Ruggieri, S, 1982) |
| "Patients with Huntington's chorea had a lower concentration of choline in lumbar spinal fluid as compared with a control group." | 1.25 | Cerebrospinal fluid choline in extrapyramidal disorders. ( Aquilonius, SM; Nyström, B; Schuberth, J; Sundwall, A, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (27.87) | 18.7374 |
| 1990's | 15 (24.59) | 18.2507 |
| 2000's | 18 (29.51) | 29.6817 |
| 2010's | 10 (16.39) | 24.3611 |
| 2020's | 1 (1.64) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, M | 2 |
| Du, N | 1 |
| Song, Z | 1 |
| Barbagallo, G | 1 |
| Arabia, G | 1 |
| Morelli, M | 1 |
| Nisticò, R | 1 |
| Novellino, F | 1 |
| Salsone, M | 1 |
| Rocca, F | 1 |
| Quattrone, A | 2 |
| Caracciolo, M | 1 |
| Sabatini, U | 1 |
| Cherubini, A | 1 |
| Zhou, B | 1 |
| Yuan, F | 1 |
| He, Z | 1 |
| Tan, C | 1 |
| Gröger, A | 2 |
| Kolb, R | 1 |
| Schäfer, R | 1 |
| Klose, U | 2 |
| Ciurleo, R | 2 |
| Di Lorenzo, G | 2 |
| Bramanti, P | 2 |
| Marino, S | 2 |
| Bonanno, L | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Martin, WR | 1 |
| Wieler, M | 1 |
| Gee, M | 1 |
| Hanstock, CC | 2 |
| Camicioli, RM | 2 |
| Griffith, HR | 1 |
| den Hollander, JA | 1 |
| Okonkwo, OC | 1 |
| O'Brien, T | 1 |
| Watts, RL | 1 |
| Marson, DC | 1 |
| Modrego, PJ | 1 |
| Fayed, N | 1 |
| Artal, J | 1 |
| Olmos, S | 1 |
| Chadzynski, G | 1 |
| Godau, J | 1 |
| Berg, D | 2 |
| Brockmann, K | 1 |
| Hilker, R | 1 |
| Pilatus, U | 1 |
| Baudrexel, S | 1 |
| Srulijes, K | 1 |
| Magerkurth, J | 1 |
| Hauser, AK | 1 |
| Schulte, C | 1 |
| Csoti, I | 1 |
| Merten, CD | 1 |
| Gasser, T | 1 |
| Hattingen, E | 1 |
| Nie, K | 1 |
| Zhang, Y | 1 |
| Huang, B | 1 |
| Wang, L | 2 |
| Zhao, J | 1 |
| Huang, Z | 1 |
| Gan, R | 1 |
| Axelson, D | 1 |
| Bakken, IJ | 1 |
| Susann Gribbestad, I | 1 |
| Ehrnholm, B | 1 |
| Nilsen, G | 1 |
| Aasly, J | 2 |
| Firbank, MJ | 1 |
| Harrison, RM | 1 |
| O'Brien, JT | 1 |
| Rottenberg, DA | 1 |
| Baik, HM | 1 |
| Choe, BY | 2 |
| Son, BC | 2 |
| Jeun, SS | 1 |
| Kim, MC | 2 |
| Lee, KS | 2 |
| Kim, BS | 2 |
| Lee, JM | 1 |
| Lee, HK | 2 |
| Suh, TS | 2 |
| Zheng, XN | 1 |
| Zhu, XC | 1 |
| Ruan, LX | 1 |
| Zhang, LJ | 1 |
| Shang, DS | 1 |
| Liu, Y | 1 |
| Korzan, JR | 1 |
| Foster, SL | 1 |
| Fisher, NJ | 1 |
| Emery, DJ | 1 |
| Bastos, AC | 1 |
| White, LR | 1 |
| Gårseth, M | 1 |
| Sonnewald, U | 1 |
| Williams, AC | 1 |
| Ramsden, DB | 1 |
| Hanoglu, L | 1 |
| Ozer, F | 1 |
| Meral, H | 1 |
| Dincer, A | 1 |
| Morales, I | 1 |
| Dopico, JG | 1 |
| Sabate, M | 1 |
| Gonzalez-Hernandez, T | 1 |
| Rodriguez, M | 1 |
| Rajakumar, B | 1 |
| Flumerfelt, BA | 1 |
| Hrycyshyn, AW | 1 |
| Rajakumar, N | 1 |
| Lucetti, C | 2 |
| Del Dotto, P | 2 |
| Gambaccini, G | 2 |
| Ceravolo, R | 1 |
| Logi, C | 1 |
| Berti, C | 1 |
| Rossi, G | 1 |
| Bianchi, MC | 2 |
| Tosetti, M | 2 |
| Murri, L | 1 |
| Bonuccelli, U | 2 |
| Llumiguano, C | 1 |
| Kovacs, N | 1 |
| Usprung, Z | 1 |
| Schwarcz, A | 1 |
| Dóczi, TP | 1 |
| Balas, I | 1 |
| Perry, RH | 1 |
| Tomlinson, BE | 1 |
| Candy, JM | 1 |
| Blessed, G | 1 |
| Foster, JF | 1 |
| Bloxham, CA | 1 |
| Perry, ER | 1 |
| Wurtman, RJ | 2 |
| Agnoli, A | 1 |
| Ruggieri, S | 1 |
| Denaro, A | 1 |
| Bruno, G | 1 |
| Holshouser, BA | 1 |
| Komu, M | 1 |
| Möller, HE | 1 |
| Zijlmans, J | 1 |
| Kolem, H | 1 |
| Hinshaw, DB | 1 |
| Sonninen, P | 1 |
| Vermathen, P | 1 |
| Heerschap, A | 1 |
| Masur, H | 1 |
| Davie, CA | 1 |
| Wenning, GK | 1 |
| Barker, GJ | 1 |
| Tofts, PS | 1 |
| Kendall, BE | 1 |
| Quinn, N | 1 |
| McDonald, WI | 1 |
| Marsden, CD | 1 |
| Miller, DH | 1 |
| Bowen, BC | 1 |
| Block, RE | 1 |
| Sanchez-Ramos, J | 1 |
| Pattany, PM | 1 |
| Lampman, DA | 1 |
| Murdoch, JB | 1 |
| Quencer, RM | 1 |
| Rodríguez-Puertas, R | 1 |
| Pazos, A | 1 |
| Pascual, J | 1 |
| Nasr, A | 1 |
| Bertrand, N | 1 |
| Giroud, M | 1 |
| Septien, L | 1 |
| Gras, P | 1 |
| Dumas, R | 1 |
| Beley, A | 1 |
| Bralet, J | 1 |
| Aotsuka, A | 1 |
| Shinotoh, H | 1 |
| Hattori, T | 1 |
| Clarke, CE | 2 |
| Lowry, M | 2 |
| Horsman, A | 1 |
| Ellis, CM | 1 |
| Lemmens, G | 1 |
| Williams, SC | 1 |
| Simmons, A | 1 |
| Dawson, J | 1 |
| Leigh, PN | 1 |
| Chaudhuri, KR | 1 |
| Cruz, CJ | 1 |
| Aminoff, MJ | 1 |
| Meyerhoff, DJ | 1 |
| Graham, SH | 1 |
| Weiner, MW | 1 |
| Tedeschi, G | 1 |
| Litvan, I | 1 |
| Bonavita, S | 1 |
| Bertolino, A | 1 |
| Lundbom, N | 1 |
| Patronas, NJ | 1 |
| Hallett, M | 1 |
| Federico, F | 1 |
| Simone, IL | 1 |
| Lucivero, V | 1 |
| Iliceto, G | 1 |
| De Mari, M | 1 |
| Giannini, P | 1 |
| Mezzapesa, DM | 1 |
| Tarantino, A | 1 |
| Lamberti, P | 1 |
| Park, JW | 1 |
| Shinn, KS | 1 |
| Taylor-Robinson, SD | 1 |
| Turjanski, N | 1 |
| Bhattacharya, S | 1 |
| Seery, JP | 1 |
| Sargentoni, J | 1 |
| Brooks, DJ | 1 |
| Bryant, DJ | 1 |
| Cox, IJ | 1 |
| Sohn, YH | 1 |
| Jeong, Y | 1 |
| Kim, HS | 1 |
| Im, JH | 1 |
| Kim, JS | 1 |
| Bernardini, S | 1 |
| Welch, MJ | 1 |
| Markham, CH | 1 |
| Jenden, DJ | 1 |
| Gerlach, J | 1 |
| Kuczenski, R | 1 |
| Segal, DS | 1 |
| Mandell, AJ | 1 |
| Nitsch, RM | 1 |
| Blusztajn, JK | 1 |
| Pittas, AG | 1 |
| Slack, BE | 1 |
| Growdon, JH | 1 |
| Manyam, BV | 1 |
| Giacobini, E | 1 |
| Colliver, JA | 1 |
| Price, DL | 1 |
| Kitt, CA | 1 |
| Struble, RG | 1 |
| Whitehouse, PJ | 1 |
| Cork, LC | 1 |
| Walker, LC | 1 |
| Cubells, JM | 1 |
| Hernando, C | 1 |
| McGeer, PL | 4 |
| McGeer, EG | 4 |
| Fibiger, HC | 2 |
| Aquilonius, SM | 1 |
| Nyström, B | 1 |
| Schuberth, J | 1 |
| Sundwall, A | 1 |
| Re', O | 1 |
| Tsubaki, T | 1 |
| Kase, M | 1 |
| Ando, K | 1 |
| Manaka, N | 1 |
| Sato, Y | 1 |
| Koh, CV | 1 |
| Ananth, JV | 1 |
| Ban, TA | 1 |
| Lehmann, HE | 1 |
| Wada, JA | 1 |
| Jung, E | 1 |
| Cotzias, GC | 1 |
| Papavasiliou, PS | 1 |
| Ginos, J | 1 |
| Steck, A | 1 |
| Düby, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Central Nervous System Uptake of Intranasal Glutathione in Parkinson's Disease[NCT02324426] | Phase 1 | 15 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for choline and Parkinson Disease
| Article | Year |
|---|---|
Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Molecu | 2014 |
A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; | 2002 |
Effects of foods and nutrients on brain neurotransmitters.
Topics: Amino Acids; Animals; Biological Transport, Active; Brain; Choline; Dopamine; Humans; Kinetics; Neur | 1984 |
[Magnetic resonance spectroscopy in Parkinson's disease and multiple system atrophy].
Topics: Aspartic Acid; Autonomic Nervous System Diseases; Basal Ganglia Diseases; Brain; Choline; Creatine; | 1997 |
Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Amyloid; Animals; Axons; Brain; Cerebral Cortex; Cho | 1985 |
Neurotransmitter synthetic enzymes.
Topics: Acetylcholine; Acetyltransferases; Adenylyl Cyclases; Aging; Aminobutyrates; Animals; Brain; Brain C | 1973 |
2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action.
Topics: Acetylcholine; Blood-Brain Barrier; Brain Chemistry; Carbon Radioisotopes; Child; Choline; Deanol; D | 1974 |
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese | 1971 |
7 trials available for choline and Parkinson Disease
| Article | Year |
|---|---|
MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms.
Topics: Aged; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Humans; Magnetic Resonance Spec | 2004 |
Influences of dopaminergic treatment on motor cortex in Parkinson disease: a MRI/MRS study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatinine; Dopamine Agonists; Female; Humans; Magnetic Resonan | 2007 |
1H-MRS experiences after bilateral DBS of the STN in Parkinson's disease.
Topics: Aged; Aspartic Acid; Choline; Creatine; Deep Brain Stimulation; Female; Humans; Magnetic Resonance S | 2008 |
Localized proton NMR spectroscopy in the striatum of patients with idiopathic Parkinson's disease: a multicenter pilot study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antiparkinson Agents; Aspartic Acid; Carbidopa; Choline | 1995 |
Clinical trial on the use of cytidine diphosphate choline in Parkinson's disease.
Topics: Choline; Clinical Trials as Topic; Cytidine Diphosphate Choline; Dopamine; Female; Humans; Male; Mid | 1988 |
[Therapeutic effects of Nicholin (CDP-choline): Parkinson's syndrome.--a double-blind study].
Topics: Adult; Aged; Choline; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; | 1974 |
Troxonium tosylate in the treatment of drug-induced extrapyramidal manifestations.
Topics: Adult; Benzoates; Choline; Clinical Trials as Topic; Esters; Ethanol; Extrapyramidal Tracts; Female; | 1971 |
46 other studies available for choline and Parkinson Disease
| Article | Year |
|---|---|
Primary motor area-related injury of anterior central gyrus in Parkinson's disease with dyskinesia: A study based on MRS and Q-space.
Topics: Aspartic Acid; Brain; Choline; Creatine; Dyskinesias; Humans; Magnetic Resonance Imaging; Magnetic R | 2023 |
Thalamic neurometabolic alterations in tremulous Parkinson's disease: A preliminary proton MR spectroscopy study.
Topics: Aged; Aspartic Acid; Choline; Creatine; Discriminant Analysis; Dopamine Plasma Membrane Transport Pr | 2017 |
Application of proton magnetic resonance spectroscopy on substantia nigra metabolites in Parkinson's disease.
Topics: Adult; Aged; Choline; Creatine; Dipeptides; Female; Humans; Magnetic Resonance Spectroscopy; Male; M | 2014 |
Dopamine reduction in the substantia nigra of Parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dopamine; Humans; Magnetic Resonance I | 2014 |
Metabolic changes in de novo Parkinson's disease after dopaminergic therapy: A proton magnetic resonance spectroscopy study.
Topics: Antiparkinson Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dopamine Agonists; Fem | 2015 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
Intact presupplementary motor area function in early, untreated Parkinson's disease.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Spe | 2008 |
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studie | 2008 |
Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson disease.
Topics: Aged; Brain; Choline; Corpus Striatum; Creatine; Diffusion Tensor Imaging; Dipeptides; Female; Gluta | 2011 |
Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's disease.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Imaging, Three-Dimensi | 2011 |
GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure.
Topics: Adenosine Diphosphate; Adult; Age of Onset; Aged; Algorithms; Aspartic Acid; Brain Chemistry; Cholin | 2012 |
Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment.
Topics: Aged; Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Choline; Cognitive Dysfunction; Early Diagn | 2013 |
Applications of neural network analyses to in vivo 1H magnetic resonance spectroscopy of Parkinson disease patients.
Topics: Aged; Aspartic Acid; Basal Ganglia; Case-Control Studies; Choline; Creatine; Female; Humans; Magneti | 2002 |
Why Rome trembles: "E avanti a lui tremava tutta Roma!" (Tosca, Act II).
Topics: Aspartic Acid; Cerebellum; Choline; Creatine; Essential Tremor; Humans; Magnetic Resonance Spectrosc | 2003 |
Proton MR spectroscopic changes in Parkinson's diseases after thalamotomy.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Mal | 2003 |
Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Cognition; Creatine; Female; Gyrus Cinguli; Huma | 2004 |
Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Case-Control Studi | 2004 |
Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases.
Topics: Animals; Choline; Embryonic Development; Epigenesis, Genetic; Evolution, Molecular; Homeostasis; Hum | 2005 |
Brainstem 1H-MR spectroscopy in patients with Parkinson's disease with REM sleep behavior disorder and IPD patients without dream enactment behavior.
Topics: Aged; Aspartic Acid; Brain Stem; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol; | 2006 |
Substantia nigra osmoregulation: taurine and ATP involvement.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Choline; Dose-Response Relati | 2007 |
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; In | 2007 |
Cortical cholinergic deficit in mentally impaired Parkinsonian patients.
Topics: Alzheimer Disease; Cerebral Cortex; Choline; Humans; Parkinson Disease | 1983 |
New strategies in the management of Parkinson's disease: a biological approach using a phospholipid precursor (CDP-choline).
Topics: Adult; Aged; Benserazide; Carbidopa; Choline; Cytidine Diphosphate Choline; Dose-Response Relationsh | 1982 |
Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Basal Ganglia; Brain Diseases; Choline; Creatine; Diagnosis, Di | 1995 |
Proton MR spectroscopy of the brain in 14 patients with Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dementia; Energy Metabolism | 1995 |
Cholinergic markers in degenerative parkinsonism: autoradiographic demonstration of high-affinity choline uptake carrier hyperactivity.
Topics: Aged; Autoradiography; Biomarkers; Brain; Carrier Proteins; Choline; Female; Hemicholinium 3; Hippoc | 1994 |
Cerebrospinal fluid choline levels in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Choline; Humans; Middle Aged; Parkinson Disease | 1993 |
Unchanged basal ganglia N-acetylaspartate and glutamate in idiopathic Parkinson's disease measured by proton magnetic resonance spectroscopy.
Topics: Aged; Apomorphine; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Humans; Magnetic | 1997 |
Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Antiparkinson Agents; Aspartic Acid; Choline; Creatine; Dopamine Agents; Humans; Levodo | 1997 |
Proton MR spectroscopic imaging of the striatum in Parkinson's disease.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Female; Humans; Magnetic | 1997 |
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Ma | 1997 |
Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.
Topics: Aged; Antiparkinson Agents; Aspartic Acid; Atrophy; Cerebral Cortex; Choline; Corpus Striatum; Creat | 1997 |
Neuronal laterality in Parkinson's disease with unilateral symptom by in vivo 1H magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Globus Pallidus; Humans; Mag | 1998 |
A proton magnetic resonance spectroscopy study of the striatum and cerebral cortex in Parkinson's disease.
Topics: Aged; Aspartic Acid; Cerebral Cortex; Choline; Corpus Striatum; Creatine; Female; Glutamic Acid; Glu | 1999 |
The brain lesion responsible for parkinsonism after carbon monoxide poisoning.
Topics: Aspartic Acid; Brain Chemistry; Carbon Monoxide Poisoning; Carrier Proteins; Choline; Cognition Diso | 2000 |
Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Magn | 2000 |
Proton magnetic resonance spectroscopy (1H-MRS) of motor cortex and basal ganglia in de novo Parkinson's disease patients.
Topics: Aged; Aspartic Acid; Basal Ganglia; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Ma | 2001 |
Acetylcholine and choline in cerebrospinal fluid of patients with Parkinson's disease and Huntington's chorea.
Topics: Acetylcholine; Adult; Aged; Choline; Humans; Huntington Disease; Middle Aged; Parkinson Disease; Ris | 1976 |
The relationship between parkinsonism and tardive dyskinesia.
Topics: Age Factors; Aminobutyrates; Baclofen; Basal Ganglia; Biperiden; Choline; Dopamine; Dyskinesia, Drug | 1977 |
Regional and subcellular distribution and kinetic properties of rat brain choline acetyltransferase--some functional considerations.
Topics: Acetyltransferases; Animals; Brain; Caudate Nucleus; Cerebellum; Choline; Disease Models, Animal; Ki | 1975 |
Evidence for a membrane defect in Alzheimer disease brain.
Topics: Aged; Alzheimer Disease; Brain; Brain Chemistry; Choline; Down Syndrome; Glycerylphosphorylcholine; | 1992 |
Cerebrospinal fluid choline levels are decreased in Parkinson's disease.
Topics: Acetylcholinesterase; Aged; Choline; Humans; Male; Middle Aged; Parkinson Disease | 1990 |
Glutamic-acid decarboxylase and choline acetylase in Huntington's chorea and Parkinson's disease.
Topics: Acetylesterase; Basal Ganglia; Carboxy-Lyases; Choline; Glutamates; Humans; Huntington Disease; Park | 1973 |
Choline acetylase and glutamic acid decarboxylase in Huntington's chorea. A preliminary study.
Topics: Acetylcholine; Acetylcholinesterase; Acetylesterase; Adult; Aged; Aminobutyrates; Autopsy; Basal Gan | 1973 |
Cerebrospinal fluid choline in extrapyramidal disorders.
Topics: Acetylcholine; Adolescent; Adult; Aged; Basal Ganglia Diseases; Brain; Brain Diseases; Brain Neoplas | 1972 |
Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase.
Topics: Acetylcholinesterase; Aminobutyrates; Animals; Carbon Isotopes; Carboxy-Lyases; Cats; Caudate Nucleu | 1971 |