choline has been researched along with Nerve Degeneration in 71 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As choline-containing compounds relate to membrane turnover, membrane dysfunction antedating neuronal death is suggested to occur in the frontal cortex in preclinical carriers of Huntington disease." | 7.74 | Decreased frontal choline and neuropsychological performance in preclinical Huntington disease. ( Alegret, M; Gómez-Ansón, B; Monte, GC; Muñoz, E; Sainz, A; Tolosa, E, 2007) |
| "The use of orally administered choline chloride in the treatment of cerebellar and spinocerebellar ataxia was investigated by a short-term double-blind crossover trial in 20 patients with ataxia." | 7.66 | Choline chloride in the treatment of cerebellar and spinocerebellar ataxia. ( Livingstone, IR; Mastaglia, FL; Pennington, RJ; Skilbeck, C, 1981) |
| "As choline-containing compounds relate to membrane turnover, membrane dysfunction antedating neuronal death is suggested to occur in the frontal cortex in preclinical carriers of Huntington disease." | 3.74 | Decreased frontal choline and neuropsychological performance in preclinical Huntington disease. ( Alegret, M; Gómez-Ansón, B; Monte, GC; Muñoz, E; Sainz, A; Tolosa, E, 2007) |
| "The authors examined the levels of NAA, creatine plus phosphocreatine, and choline-containing molecules in the left dorsolateral prefrontal cortex of 14 bipolar disorder patients (mean age=15." | 3.73 | Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. ( Axelson, D; Birmaher, B; Brambilla, P; Keshavan, MS; Nicoletti, MA; Ramos, RT; Ryan, N; Sassi, RB; Soares, JC; Stanley, JA, 2005) |
| " We also did not find a correlation between the amount of Glx and the initial Glasgow Coma Scale score, duration of coma, nor with changes in spectral metabolites, including N-acetyl aspartate, choline, and myoinositol." | 3.72 | Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. ( Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K, 2004) |
| "The use of orally administered choline chloride in the treatment of cerebellar and spinocerebellar ataxia was investigated by a short-term double-blind crossover trial in 20 patients with ataxia." | 3.66 | Choline chloride in the treatment of cerebellar and spinocerebellar ataxia. ( Livingstone, IR; Mastaglia, FL; Pennington, RJ; Skilbeck, C, 1981) |
| "Autosomal-dominant spinocerebellar ataxia type 1 (SCA1) is an adult-onset progressive disorder with well-characterized neurodegeneration in the cerebellum and brainstem." | 1.40 | Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1. ( Brandt, AU; Doss, S; Endres, M; Oberwahrenbrock, T; Paul, F; Rinnenthal, JL, 2014) |
| "Spinocerebellar ataxia type 1 (SCA1) is a hereditary, progressive and fatal movement disorder that primarily affects the cerebellum." | 1.39 | Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1. ( Brent Clark, H; Eberly, LE; Emir, UE; Öz, G; Vollmers, ML, 2013) |
| " The results showed that piperine at all dosage range used in this study significantly improved memory impairment and neurodegeneration in hippocampus." | 1.36 | Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. ( Chonpathompikunlert, P; Muchimapura, S; Wattanathorn, J, 2010) |
| "The study included 12 patients with progressive supranuclear palsy, 10 with Parkinson's disease, nine with corticobasal degeneration and 11 age-matched normal control subjects." | 1.30 | Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. ( Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G, 1997) |
| "Choline was taken up by a single saturable process with apparent Km = 3." | 1.28 | Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats. ( Iwata, M; Nagata, Y; Tamaru, M, 1989) |
| "When DAPI was injected intraocularly instead of being applied to the optic tract, a regular mosaic of neurons in the ganglion cell layer was selectively stained, and two bands of fluorescence were observed in the inner plexiform layer, at the level where two bands of radioactive acetylcholine were observed in radioautographs." | 1.27 | Acetylcholine-synthesizing amacrine cells: identification and selective staining by using radioautography and fluorescent markers. ( Hayden, SA; Masland, RH; Mills, JW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (42.25) | 18.7374 |
| 1990's | 11 (15.49) | 18.2507 |
| 2000's | 19 (26.76) | 29.6817 |
| 2010's | 9 (12.68) | 24.3611 |
| 2020's | 2 (2.82) | 2.80 |
| Authors | Studies |
|---|---|
| Gautier, MK | 1 |
| Kelley, CM | 1 |
| Lee, SH | 1 |
| Alldred, MJ | 1 |
| McDaid, J | 1 |
| Mufson, EJ | 1 |
| Stutzmann, GE | 1 |
| Ginsberg, SD | 1 |
| Prabhu, GS | 1 |
| K G Rao, M | 1 |
| Rai, KS | 1 |
| Khan, MSI | 1 |
| Nabeka, H | 1 |
| Islam, F | 1 |
| Shimokawa, T | 1 |
| Saito, S | 1 |
| Li, X | 1 |
| Kawabe, S | 1 |
| Hamada, F | 1 |
| Tachibana, T | 1 |
| Matsuda, S | 1 |
| de Munck, E | 1 |
| Muñoz-Sáez, E | 1 |
| Miguel, BG | 1 |
| Solas, MT | 1 |
| Ojeda, I | 1 |
| Martínez, A | 1 |
| Gil, C | 1 |
| Arahuetes, RM | 1 |
| Emir, UE | 1 |
| Brent Clark, H | 1 |
| Vollmers, ML | 1 |
| Eberly, LE | 1 |
| Öz, G | 1 |
| Doss, S | 1 |
| Brandt, AU | 1 |
| Oberwahrenbrock, T | 1 |
| Endres, M | 2 |
| Paul, F | 1 |
| Rinnenthal, JL | 1 |
| Erichsen, AK | 1 |
| Server, A | 1 |
| Landrø, NI | 1 |
| Sandvik, L | 1 |
| Tallaksen, CM | 1 |
| Atmaca, M | 1 |
| Yildirim, H | 1 |
| Ozdemir, H | 1 |
| Koc, M | 1 |
| Ozler, S | 1 |
| Tezcan, E | 1 |
| Qian, J | 1 |
| Herrera, JJ | 1 |
| Narayana, PA | 1 |
| Chonpathompikunlert, P | 1 |
| Wattanathorn, J | 1 |
| Muchimapura, S | 1 |
| Biasi, E | 1 |
| Sudharshan, N | 1 |
| Hanstock, C | 1 |
| Hui, B | 1 |
| Pyra, T | 1 |
| Johnston, W | 1 |
| Kalra, S | 1 |
| Brockmann, K | 1 |
| Hilker, R | 1 |
| Pilatus, U | 1 |
| Baudrexel, S | 1 |
| Srulijes, K | 1 |
| Magerkurth, J | 1 |
| Hauser, AK | 1 |
| Schulte, C | 1 |
| Csoti, I | 1 |
| Merten, CD | 1 |
| Gasser, T | 1 |
| Berg, D | 1 |
| Hattingen, E | 1 |
| Humpel, C | 1 |
| Weis, C | 1 |
| HASUE, M | 1 |
| Harms, C | 2 |
| Bösel, J | 1 |
| Lautenschlager, M | 2 |
| Harms, U | 1 |
| Braun, JS | 1 |
| Hörtnagl, H | 3 |
| Dirnagl, U | 2 |
| Kwiatkowski, DJ | 1 |
| Fink, K | 1 |
| Dudas, B | 1 |
| Hanin, I | 1 |
| Rose, M | 1 |
| Wülfert, E | 1 |
| Ashwal, S | 1 |
| Holshouser, B | 1 |
| Tong, K | 1 |
| Serna, T | 1 |
| Osterdock, R | 1 |
| Gross, M | 1 |
| Kido, D | 1 |
| Crochemore, C | 1 |
| Peña-Altamira, E | 1 |
| Virgili, M | 1 |
| Monti, B | 1 |
| Contestabile, A | 5 |
| Sassi, RB | 1 |
| Stanley, JA | 1 |
| Axelson, D | 1 |
| Brambilla, P | 1 |
| Nicoletti, MA | 1 |
| Keshavan, MS | 1 |
| Ramos, RT | 1 |
| Ryan, N | 1 |
| Birmaher, B | 1 |
| Soares, JC | 1 |
| Boucard, CC | 1 |
| Hoogduin, JM | 1 |
| van der Grond, J | 1 |
| Cornelissen, FW | 1 |
| Gómez-Ansón, B | 1 |
| Alegret, M | 1 |
| Muñoz, E | 1 |
| Sainz, A | 1 |
| Monte, GC | 1 |
| Tolosa, E | 1 |
| Casey, PA | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 1 |
| Saraswati, M | 1 |
| Robertson, CL | 1 |
| Masland, RH | 1 |
| Mills, JW | 1 |
| Hayden, SA | 1 |
| Migani, P | 2 |
| Poli, A | 2 |
| Villani, L | 4 |
| Natarajan, V | 1 |
| Yao, JK | 1 |
| Dyck, PJ | 1 |
| Schmid, HH | 1 |
| Austin, CA | 1 |
| Mundy, KI | 1 |
| Dorey, S | 1 |
| Flentge, F | 1 |
| Hajonides-van Der Meulen, WM | 1 |
| Lakke, JP | 1 |
| Teelken, AW | 1 |
| Livingstone, IR | 1 |
| Mastaglia, FL | 1 |
| Pennington, RJ | 1 |
| Skilbeck, C | 1 |
| Cohen, BM | 1 |
| Renshaw, PF | 1 |
| Stoll, AL | 1 |
| Wurtman, RJ | 1 |
| Yurgelun-Todd, D | 1 |
| Babb, SM | 1 |
| Berger, ML | 1 |
| Havelec, L | 1 |
| Hornykiewicz, O | 1 |
| Massieu, L | 1 |
| Morales-Villagrán, A | 1 |
| Tapia, R | 1 |
| Smith, DW | 2 |
| Mount, RJ | 2 |
| Choe, BY | 1 |
| Suh, TS | 1 |
| Choi, KH | 1 |
| Shinn, KS | 1 |
| Park, CK | 1 |
| Kang, JK | 1 |
| Tedeschi, G | 2 |
| Bertolino, A | 2 |
| Massaquoi, SG | 1 |
| Campbell, G | 1 |
| Patronas, NJ | 2 |
| Bonavita, S | 2 |
| Barnett, AS | 1 |
| Alger, JR | 1 |
| Hallett, M | 2 |
| Maier, M | 1 |
| Ron, MA | 1 |
| Litvan, I | 1 |
| Lundbom, N | 1 |
| Deicken, RF | 1 |
| Zhou, L | 1 |
| Schuff, N | 1 |
| Weiner, MW | 1 |
| Lança, AJ | 1 |
| Adamson, KL | 1 |
| Coen, KM | 1 |
| Chow, BL | 1 |
| Corrigall, WA | 1 |
| Onufriev, MV | 1 |
| Gulyaeva, NV | 1 |
| Freyer, D | 1 |
| Sehmsdorf, U | 1 |
| Ruscher, K | 1 |
| Moiseeva, YV | 1 |
| Arnswald, A | 1 |
| Victorov, I | 1 |
| Weber, JR | 1 |
| Araki, T | 1 |
| Tanji, H | 1 |
| Fujihara, K | 1 |
| Kato, H | 1 |
| Imai, Y | 1 |
| Mizugaki, M | 1 |
| Itoyama, Y | 1 |
| Simone, IL | 1 |
| Tortorella, C | 1 |
| Federico, F | 1 |
| Liguori, M | 1 |
| Lucivero, V | 1 |
| Giannini, P | 1 |
| Carrara, D | 1 |
| Bellacosa, A | 1 |
| Livrea, P | 1 |
| Yassin, L | 1 |
| Gillo, B | 1 |
| Kahan, T | 1 |
| Halevi, S | 1 |
| Eshel, M | 1 |
| Treinin, M | 1 |
| Strahlendorf, JC | 1 |
| Acosta, S | 1 |
| Miles, R | 1 |
| Strahlendorf, HK | 1 |
| Khiat, A | 1 |
| Yared, Z | 1 |
| Bard, C | 1 |
| Lacroix, A | 1 |
| Boulanger, Y | 1 |
| Murata, T | 1 |
| Kimura, H | 1 |
| Omori, M | 1 |
| Kado, H | 1 |
| Kosaka, H | 1 |
| Iidaka, T | 1 |
| Itoh, H | 1 |
| Wada, Y | 1 |
| Zaczek, R | 1 |
| Schwarcz, R | 1 |
| Coyle, JT | 1 |
| Hunt, SP | 1 |
| Streit, P | 1 |
| Künzle, H | 1 |
| Cuénod, M | 1 |
| Csillik, B | 1 |
| Arbilla, S | 1 |
| Perec, CJ | 1 |
| Stefano, FJ | 1 |
| Javoy, F | 2 |
| Sotelo, C | 1 |
| Herbet, A | 1 |
| Agid, Y | 1 |
| Knüsel, B | 1 |
| Beck, KD | 1 |
| Winslow, JW | 1 |
| Rosenthal, A | 1 |
| Burton, LE | 1 |
| Widmer, HR | 1 |
| Nikolics, K | 1 |
| Hefti, F | 1 |
| Rothe, T | 1 |
| Hanisch, UK | 1 |
| Krohn, K | 1 |
| Schliebs, R | 1 |
| Härtig, W | 1 |
| Webster, HH | 1 |
| Biesold, D | 1 |
| Callahan, JW | 1 |
| Tamaru, M | 1 |
| Iwata, M | 1 |
| Nagata, Y | 1 |
| Bissoli, R | 2 |
| Garolini, S | 1 |
| Guarnieri, T | 1 |
| Battistini, S | 1 |
| Saverino, O | 1 |
| Amir, A | 1 |
| Pittel, Z | 1 |
| Shahar, A | 1 |
| Fisher, A | 1 |
| Heldman, E | 1 |
| Stephens, PH | 1 |
| Tagari, P | 1 |
| Cuello, AC | 1 |
| Munarini, A | 1 |
| Chiodini, O | 1 |
| Fonnum, F | 1 |
| Colhoun, EH | 1 |
| Myles, LA | 1 |
| Rylett, RJ | 1 |
| Ekström, J | 1 |
| Emmelin, N | 1 |
| Tucek, S | 1 |
| Kelly, JS | 1 |
| Gottesfeld, Z | 1 |
| Schon, F | 1 |
| Hui, FW | 1 |
| Smith, AA | 1 |
| Storm-Mathisen, J | 1 |
| Paggi, P | 1 |
| Toschi, G | 1 |
| Ciaranello, RD | 1 |
| Jacobowitz, D | 1 |
| Axelrod, J | 1 |
| Sethy, VH | 1 |
| Roth, RH | 1 |
| Kuhar, MJ | 1 |
| Van Woert, MH | 1 |
| Weitsen, HA | 1 |
| Norvell, JE | 1 |
2 reviews available for choline and Nerve Degeneration
| Article | Year |
|---|---|
Recent advances in the use of selective neuron-destroying agents for neurobiological research.
Topics: Animals; Aziridines; Choline; Colchicine; Folic Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kain | 1984 |
Synaptochemistry of acetylcholine metabolism in a cholinergic neuron.
Topics: Acetates; Acetylcholine; Acetylcholinesterase; Animals; Axons; Cell Membrane; Choline; Cytoplasm; Hi | 1975 |
69 other studies available for choline and Nerve Degeneration
| Article | Year |
|---|---|
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Forebrain; Choline; Choline O-Acetyltransferase; Dietary Sup | 2023 |
Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats- exploring the comparable benefits of choline and DHA or environmental enrichment.
Topics: Animals; Animals, Newborn; Behavior, Animal; Choline; Diet, High-Fat; Disease Models, Animal; Docosa | 2021 |
Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Caspase 3; Chick Embryo; Chickens; Choline; | 2017 |
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Cre | 2013 |
Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1.
Topics: Animals; Ataxin-1; Ataxins; Cerebellum; Choline; Disease Models, Animal; Disease Progression; Gene K | 2013 |
Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Female; | 2014 |
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations.
Topics: Adenosine Triphosphatases; Adult; Aspartic Acid; Biomarkers; Choline; Cognition Disorders; Creatine; | 2009 |
Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Functional Laterality; | 2009 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Imm | 2010 |
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Aziridines; Benzodioxoles; Choline; Cog | 2010 |
Effects of postnatal dietary choline manipulation against MK-801 neurotoxicity in pre- and postadolescent rats.
Topics: Animals; Animals, Newborn; Brain; Choline; Cytoprotection; Dietary Supplements; Disease Models, Anim | 2010 |
Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Female; Gyrus Cinguli; Humans; M | 2011 |
GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure.
Topics: Adenosine Diphosphate; Adult; Age of Onset; Aged; Algorithms; Aspartic Acid; Brain Chemistry; Cholin | 2012 |
Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices. Implication in Alzheimer's disease?
Topics: Acetyl Coenzyme A; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Cell Survival; Cerebral Cor | 2002 |
[EXPERIMENTAL STUDY ON THE CORRELATION OF ELECTROMYOGRAPHICAL AND MORPHOLOGICAL FINDINGS ON SKELETAL MUSCLE].
Topics: Choline; Cholinesterases; Denervation; Electromyography; Histocytochemistry; Muscle, Skeletal; Muscl | 1964 |
Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization.
Topics: Actin Cytoskeleton; Animals; Apoptosis; Aziridines; Calcium Channels; Calcium Signaling; Caspase 3; | 2004 |
Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aziridines; Cell Death; Choline; Choline O-Acetyl | 2004 |
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Com | 2004 |
Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Brain Stem; Cerebra | 2005 |
Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients.
Topics: Adolescent; Adult; Age Factors; Aspartic Acid; Bipolar Disorder; Child; Choline; Creatine; Female; H | 2005 |
Occipital proton magnetic resonance spectroscopy (1H-MRS) reveals normal metabolite concentrations in retinal visual field defects.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glaucoma; Humans; Mac | 2007 |
Decreased frontal choline and neuropsychological performance in preclinical Huntington disease.
Topics: Adult; Basal Ganglia; Cell Membrane; Choline; Cognition; Cognition Disorders; Down-Regulation; Femal | 2007 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
Acetylcholine-synthesizing amacrine cells: identification and selective staining by using radioautography and fluorescent markers.
Topics: Acetylcholine; Animals; Autoradiography; Axonal Transport; Axons; Choline; Efferent Pathways; Fluore | 1984 |
Early stimulation of phosphatidylcholine biosynthesis during Wallerian degeneration of rat sciatic nerve.
Topics: Animals; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Diacylglycerol Cholinephos | 1982 |
Low dose choline chloride in cerebellar degeneration.
Topics: Adolescent; Adult; Aged; Cerebellar Ataxia; Cerebellar Diseases; Choline; Dose-Response Relationship | 1984 |
CSF choline levels in groups of patients with cranial trauma or extrapyramidal disorders.
Topics: Adult; Basal Ganglia Diseases; Blood-Brain Barrier; Brain Concussion; Brain Injuries; Choline; Femal | 1984 |
Choline chloride in the treatment of cerebellar and spinocerebellar ataxia.
Topics: Adult; Cerebellar Ataxia; Choline; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fr | 1981 |
Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood-Brain Barrier; Brain | 1995 |
Role of glucocorticoids in the cholinergic degeneration in rat hippocampus induced by ethylcholine aziridinium (AF64A).
Topics: Acetylcholine; Adrenalectomy; Animals; Aziridines; Cerebral Ventricles; Choline; Choline O-Acetyltra | 1993 |
Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study.
Topics: Animals; Cell Death; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dicarboxylic Acids; Dizo | 1995 |
Damage to cochlear efferents following AF64A intoxication.
Topics: Animals; Aziridines; Cell Membrane; Cell Survival; Chinchilla; Choline; Cochlea; Dose-Response Relat | 1993 |
Neuronal dysfunction in patients with closed head injury evaluated by in vivo 1H magnetic resonance spectroscopy.
Topics: Algorithms; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Energy Metabolism; Glasgow Coma Scale | 1995 |
Proton magnetic resonance spectroscopic imaging in patients with cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Humans; Lac | 1996 |
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali | 1996 |
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Ma | 1997 |
Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; F | 1997 |
The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study.
Topics: Acetylcholine; Animals; Aziridines; Behavior, Animal; Choline; Cholinergic Fibers; Denervation; Dihy | 2000 |
Role of nitric oxide in the ethylcholine aziridinium model of delayed apoptotic neurodegeneration in vivo and in vitro.
Topics: Animals; Apoptosis; Aziridines; Cells, Cultured; Cerebral Cortex; Cerebral Ventricles; Choline; Chol | 2000 |
Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats.
Topics: Animals; Autoradiography; Choline; Cholinergic Agents; Corpus Striatum; Dopamine Antagonists; Hemich | 2000 |
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magn | 2001 |
Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Calcium; Chelating Agents; Chemotaxis; Choline | 2001 |
Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha7 nicotinic receptor.
Topics: Aconitine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha7 Nicotinic Acetylcholine | 2001 |
Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Brain Injuries; Cell Membrane; Choline; Crea | 2001 |
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy | 2001 |
Long-term sequelae of striatal kainate lesion.
Topics: Acetylcholine; Animals; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; gamma-Amino | 1978 |
Characterization of the pigeon isthmo-tectal pathway by selective uptake and retrograde movement of radioactive compounds and by Golgi-like horseradish peroxidase labeling.
Topics: Acetylcholinesterase; Amino Acids; Animals; Axonal Transport; Choline; Columbidae; gamma-Aminobutyri | 1977 |
Delay in nerve degeneration after sympathectomy of the submaxillary gland of the rat by treatment with pargyline, nialamide or beta-TM-10.
Topics: Animals; Choline; Female; In Vitro Techniques; Metaraminol; Monoamine Oxidase; Nerve Degeneration; N | 1977 |
Partial selectivity of 6-OHDA induced neuronal degeneration after intraissular injection in the brain with special reference to the nigro-striatal dopamine system.
Topics: Animals; Choline; Corpus Striatum; Dopamine; Hydroxydopamines; Nerve Degeneration; Serotonin; Substa | 1975 |
Specificity of dopaminergic neuronal degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system.
Topics: Animals; Choline; Copper; Corpus Striatum; Dopamine; Electrocoagulation; Hydroxydopamines; Male; Ner | 1976 |
Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain.
Topics: Animals; Axons; Brain-Derived Neurotrophic Factor; Choline; Denervation; Dopamine; Female; Nerve Deg | 1992 |
Changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury.
Topics: Acetylcholinesterase; Afferent Pathways; Animals; Brain Mapping; Choline; Choline O-Acetyltransferas | 1990 |
Selective damage to cochlear efferents by the choline neurotoxin ethylcholine mustard aziridinium ion (AF64A) in the chinchilla.
Topics: Animals; Aziridines; Chinchilla; Choline; Cochlea; Efferent Pathways; Hair Cells, Auditory; Microsco | 1989 |
Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats.
Topics: Aging; Animals; Biological Transport; Choline; Denervation; Female; Ganglia, Sympathetic; Hemicholin | 1989 |
Effect of AF64A on the cholinergic systems of the retina and optic tectum of goldfish.
Topics: Animals; Aziridines; Azirines; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Eye; Glutam | 1988 |
Cholinotoxicity of the ethylcholine aziridinium ion in primary cultures from rat central nervous system.
Topics: Acetylcholinesterase; Animals; Aziridines; Azirines; Brain; Cells, Cultured; Choline; Cholinergic Fi | 1988 |
Ethylcholine mustard aziridinium ion lesions of the rat cortex result in retrograde degeneration of basal forebrain cholinergic neurons: implications for animal models of neurodegenerative disease.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Basal Ganglia; Cerebral Cortex; Choline; Choline O | 1987 |
Modification of ultrastructural and neurochemical parameters in synaptosomes of the retino-deprived goldfish optic tectum.
Topics: Acetylcholine; Animals; Aspartic Acid; Choline; Functional Laterality; Goldfish; Microscopy, Electro | 1986 |
Ultrastructural and neurochemical effects of the presumed cholinergic toxin AF64A in the rat interpeduncular nucleus.
Topics: Animals; Aziridines; Azirines; Brain Chemistry; Choline; Cholinergic Fibers; gamma-Aminobutyric Acid | 1986 |
An attempt to produce cholinergic hypofunction in rat brain using choline mustard aziridinium ion: neurochemical and histological parameters.
Topics: Alzheimer Disease; Animals; Brain; Choline; Disease Models, Animal; Hippocampus; Male; Nerve Degener | 1986 |
Movement of choline acetyltransferase in axons disconnected from their cell bodies.
Topics: Acyltransferases; Animals; Axonal Transport; Axons; Choline; Diaphragm; Ligation; Male; Nerve Degene | 1971 |
Transport and changes of activity of choline acetyltransferase in the peripheral stump of an interrupted nerve.
Topics: Acetylcholinesterase; Acetyltransferases; Animals; Axonal Transport; Biological Transport; Carbon Ra | 1974 |
Reduction in GADI activity from the dorsal lateral region of the deafferented rat spinal cord.
Topics: Acetyltransferases; Aminobutyrates; Animals; Autoradiography; Carboxy-Lyases; Choline; Glutamates; L | 1973 |
Degeneration of taste buds and lateral line organs in the salamander treated with cholinolytic drugs.
Topics: Acetylcholine; Animals; Atropine; Choline; Epithelium; Hemicholinium 3; Mechanoreceptors; Nerve Dege | 1972 |
Glutamate decarboxylase in the rat hippocampal region after lesions of the afferent fibre systems. Evidence that the enzyme is localized in intrinsic neurones.
Topics: Acetylcholinesterase; Aminobutyrates; Animals; Axons; Carboxy-Lyases; Cerebellar Nuclei; Cerebellum; | 1972 |
Effects of denervation and lack of calcium on the action of Latrodectus venom on rat sympathetic ganglion.
Topics: Action Potentials; Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Calci | 1972 |
Effect of dexamethasone on phenylethanolamine N-methyltransferase in chromaffin tissue of the neonatal rat.
Topics: Acetyltransferases; Adrenal Cortex Hormones; Animals; Animals, Newborn; Choline; Chromaffin System; | 1973 |
Choline and acetylcholine: regional distribution and effect of degeneration of cholinergic nerve terminals in the rat hippocampus.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Choline; Hippocampus; Male; Microwaves; Nerve Degene | 1973 |
Cholinergic innervation of the autotransplanted canine kidney.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Autonomic Nervous System; Choline; Dogs; Female; Gangl | 1969 |