choline has been researched along with Myasthenia Gravis in 18 studies
Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have found that mutant acetylcholine receptor channels (AChRs) that cause slow-channel congenital myasthenic syndromes are activated by serum and that the high frequency of openings in serum is reduced by treatment with choline oxidase." | 7.70 | Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. ( Auerbach, A; Engel, AG; Zhou, M, 1999) |
| "The neuromuscular block of myasthenia gravis has the characteristics of an antidepolarizing (competitive block), similar to that produced by d-tubocurarine in normal subjects: progressive decrease in muscle action potentials evoked by two or more nerve stimuli, posttetanic facilitation, posttetanic fatigue, inhibition of the depolarizing action of acetylcholine (ACh) or anticholinesterase compounds, and reversal of the block by ACh or anticholinesterase compounds." | 4.75 | Characteristics and mechanism of neuromuscular block in myasthenia gravis. ( Grob, D; Namba, T, 1976) |
| "We have found that mutant acetylcholine receptor channels (AChRs) that cause slow-channel congenital myasthenic syndromes are activated by serum and that the high frequency of openings in serum is reduced by treatment with choline oxidase." | 3.70 | Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. ( Auerbach, A; Engel, AG; Zhou, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (94.44) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| TORDA, C | 1 |
| WOLFF, HG | 1 |
| PENNINGTON, G | 1 |
| WILSON, A | 1 |
| MONRO, P | 1 |
| BOWMAN, WC | 1 |
| HEMSORTH, BA | 1 |
| RAND, MJ | 1 |
| RUBINSTEIN, HM | 1 |
| DIETZ, AA | 1 |
| CZEBOTAR, V | 1 |
| Kranz, H | 1 |
| Caddy, DJ | 1 |
| Williams, AM | 1 |
| Gay, W | 1 |
| Martin-Du Pan, RC | 1 |
| Wurtman, RJ | 1 |
| Molenaar, PC | 1 |
| Newsom-Davis, J | 1 |
| Polak, RL | 1 |
| Vincent, A | 1 |
| Zhou, M | 1 |
| Engel, AG | 2 |
| Auerbach, A | 1 |
| Grob, D | 1 |
| Namba, T | 1 |
| Stein, C | 1 |
| Moore, W | 1 |
| Weinreich, D | 1 |
| Mayer, RF | 1 |
| Mora, M | 1 |
| Lambert, EH | 1 |
| Simpson, JA | 1 |
| Gentner, DR | 1 |
| Rosenberg, RN | 1 |
| Flacke, W | 1 |
| Martin, K | 1 |
| Cookson, JC | 1 |
| Paton, WD | 1 |
| Whittaker, VP | 1 |
4 reviews available for choline and Myasthenia Gravis
| Article | Year |
|---|---|
[The role of nutrition in the synthesis of neurotransmitters and in cerebral functions: clinical implications].
Topics: Alzheimer Disease; Amino Acids; Choline; Choline O-Acetyltransferase; Diabetes Mellitus; Dopa Decarb | 1981 |
Characteristics and mechanism of neuromuscular block in myasthenia gravis.
Topics: Acetylcholine; Action Potentials; Animals; Choline; Decamethonium Compounds; Electric Stimulation; E | 1976 |
Treatment of myasthenia gravis.
Topics: Acetates; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Ambenonium Chloride; Aminophylline; | 1973 |
Mechanisms of neuromuscular block. A review article.
Topics: Acetylcholine; Action Potentials; Animals; Cats; Cell Membrane; Choline; Humans; Membrane Potentials | 1969 |
14 other studies available for choline and Myasthenia Gravis
| Article | Year |
|---|---|
Studies on myasthenia gravis; apparent curare-like effect of compounds that decrease acetylcholine synthesis.
Topics: Acetylcholine; Choline; Curare; Myasthenia Gravis; Synaptic Transmission | 1946 |
Plasma choline concentrations in normal and myasthenic subjects.
Topics: Choline; Humans; Myasthenia Gravis | 1961 |
Treatment of myasthenia gravis.
Topics: Calcium; Choline; Humans; Hyperthyroidism; Myasthenia Gravis | 1963 |
Myasthenic-like features of the neuromuscular transmission failure produced by triethylcholine.
Topics: Choline; Humans; Myasthenia Gravis; Neuromuscular Junction | 1962 |
UNUSUAL URINARY COMPOUND IN PATIENTS HOMOZYGOUS FOR HEREDITARY ATYPICAL SERUM CHOLINESTERASE.
Topics: Acetylcholine; Choline; Cholinesterases; Chromatography; Clinical Enzyme Tests; Dibucaine; Fluoresce | 1964 |
Myasthenic syndrome: effect of choline, plasmapheresis and tests for circulating factor.
Topics: Action Potentials; Choline; Female; Guanidines; Humans; Middle Aged; Myasthenia Gravis; Neuromuscula | 1980 |
Choline acetyltransferase in skeletal muscle from patients with myasthenia gravis.
Topics: Choline; Choline O-Acetyltransferase; Humans; Kinetics; Muscles; Myasthenia Gravis; Physostigmine; R | 1981 |
Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes.
Topics: Animals; Cell Line; Choline; Humans; Kidney; Membrane Potentials; Mice; Mutation; Myasthenia Gravis; | 1999 |
Choline levels in plasma of myasthenia gravis patients and normal individuals.
Topics: Adolescent; Adult; Aged; Choline; Female; Humans; Male; Middle Aged; Myasthenia Gravis | 1978 |
Synaptic vesicle abnormality in familial infantile myasthenia.
Topics: Adult; Child, Preschool; Choline; Hemicholinium 3; Humans; Male; Membrane Potentials; Myasthenia Gra | 1987 |
A morphological explanation of the transmission defect in myasthenia gravis.
Topics: Acetylcholine; Animals; Anura; Cats; Choline; Decamethonium Compounds; Dogs; Guinea Pigs; Haplorhini | 1971 |
Choline acetyltransferase and acetylcholinesterase. Their role in the causes of myasthenia gravis.
Topics: Acetylcholinesterase; Acetyltransferases; Adult; Choline; Cholinesterases; Chromatography, Paper; Fe | 1972 |
Effects of quaternary ammonium compounds on choline transport in red cells.
Topics: Acetylcholine; Biological Transport, Active; Carbachol; Choline; Decamethonium Compounds; Erythrocyt | 1969 |
Origin and function of synaptic vesicles.
Topics: Acetylcholine; Amino Acids; Animals; Centrifugation, Zonal; Cerebral Cortex; Choline; Chromatography | 1971 |