choline has been researched along with Multiple System Atrophy in 6 studies
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Excerpt | Relevance | Reference |
|---|---|---|
| "目的：应用磁共振氢质子波谱(1H-proton magnetic resonance spectroscopy，1H-MRS)检测合并认知功能障碍的多系统萎缩(multiple system atrophy，MSA)患者双侧额叶的代谢特点。方法：收集23例合并认知功能障碍的MSA患者(研究组1)及19例认知功能正常的MSA患者(研究组2)，另选48名与两组MSA患者年龄、性别匹配的正常人(正常对照组)均进行1H-MRS检查，其包括双侧额叶区N-乙酰天门冬氨酸(N-acetylaspartate，NAA)/肌酸(creatine，Cr)、胆碱(choline，Cho)/肌酸(Cr)、肌醇(myoinositol，mI)/肌酸(Cr)的测定。结果：合并认知障碍的MSA患者双侧额叶NAA/Cr值较认知正常的MSA患者和正常对照组显著降低(P<0." | 3.81 | [1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and cognitive dysfunction]. ( Hou, X; Jiang, H; Sun, Z; Tang, B; Xiang, X; Zhou, G, 2015) |
| "Six patients with idiopathic Parkinson's disease (IPD), six with clinically probable multiple system atrophy and six control subjects underwent quantitative proton magnetic resonance spectroscopy (MRS)." | 1.31 | Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy. ( Clarke, CE; Lowry, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiang, X | 1 |
| Hou, X | 1 |
| Sun, Z | 1 |
| Zhou, G | 1 |
| Tang, B | 1 |
| Jiang, H | 1 |
| Takado, Y | 1 |
| Igarashi, H | 1 |
| Terajima, K | 1 |
| Shimohata, T | 1 |
| Ozawa, T | 1 |
| Okamoto, K | 1 |
| Nishizawa, M | 1 |
| Nakada, T | 1 |
| Boesch, SM | 1 |
| Wolf, C | 1 |
| Seppi, K | 1 |
| Felber, S | 1 |
| Wenning, GK | 1 |
| Schocke, M | 1 |
| Terakawa, H | 1 |
| Abe, K | 1 |
| Watanabe, Y | 1 |
| Nakamura, M | 1 |
| Fujita, N | 1 |
| Hirabuki, N | 1 |
| Yanagihara, T | 1 |
| Federico, F | 1 |
| Simone, IL | 1 |
| Lucivero, V | 1 |
| Mezzapesa, DM | 1 |
| de Mari, M | 1 |
| Lamberti, P | 1 |
| Petruzzellis, M | 1 |
| Ferrari, E | 1 |
| Clarke, CE | 1 |
| Lowry, M | 1 |
2 trials available for choline and Multiple System Atrophy
| Article | Year |
|---|---|
Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0-T magnetic resonance spectroscopy study.
Topics: Aged; Aspartic Acid; Biomarkers; Choline; Creatinine; Dipeptides; Feasibility Studies; Female; Gluta | 2011 |
Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Cerebellum; Choline; Creatine; Diagnosis, Differential; Fe | 2007 |
4 other studies available for choline and Multiple System Atrophy
| Article | Year |
|---|---|
[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and
cognitive dysfunction].
Topics: Aspartic Acid; Choline; Cognition Disorders; Creatine; Frontal Lobe; Humans; Inositol; Multiple Syst | 2015 |
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Pro | 1999 |
Usefulness of proton magnetic resonance spectroscopy in differentiating parkinsonian syndromes.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Diagnosis, Differential; Disease Progression; | 1999 |
Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Magn | 2000 |