choline has been researched along with Multiple Sclerosis in 75 studies
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.00) | 18.7374 |
| 1990's | 23 (30.67) | 18.2507 |
| 2000's | 31 (41.33) | 29.6817 |
| 2010's | 15 (20.00) | 24.3611 |
| 2020's | 3 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trostel, C | 1 |
| Laichinger, K | 1 |
| Hauser, TK | 1 |
| Saur, S | 1 |
| Krumbholz, M | 1 |
| Henes, J | 1 |
| Ziemann, U | 1 |
| Kowarik, MC | 1 |
| Mueller, C | 1 |
| Baird, JF | 1 |
| Motl, RW | 1 |
| Hnilicová, P | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Grendár, M | 1 |
| Bittšanský, M | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Zeleňák, K | 1 |
| Lehotský, J | 1 |
| Dobrota, D | 1 |
| Kurča, E | 1 |
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
| Anheyer, D | 1 |
| Medina, DN | 1 |
| Cardozo, V | 1 |
| Remy, D | 1 |
| Hannan, N | 1 |
| Garber, A | 1 |
| Velayos, M | 1 |
| Muñoz-Serrano, AJ | 1 |
| Estefanía-Fernández, K | 1 |
| Sarmiento Caldas, MC | 1 |
| Moratilla Lapeña, L | 1 |
| López-Santamaría, M | 1 |
| López-Gutiérrez, JC | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Shen, S | 1 |
| Zhang, B | 2 |
| Yu, WW | 1 |
| Toyoda, H | 1 |
| Huang, DQ | 1 |
| Le, MH | 1 |
| Nguyen, MH | 1 |
| Huang, R | 1 |
| Zhu, L | 1 |
| Wang, J | 6 |
| Xue, L | 1 |
| Liu, L | 2 |
| Yan, X | 2 |
| Huang, S | 1 |
| Li, Y | 6 |
| Xu, T | 1 |
| Li, C | 2 |
| Ji, F | 1 |
| Ming, F | 1 |
| Zhao, Y | 2 |
| Cheng, J | 1 |
| Wang, Y | 3 |
| Zhao, H | 1 |
| Hong, S | 1 |
| Chen, K | 2 |
| Zhao, XA | 1 |
| Zou, L | 1 |
| Sang, D | 1 |
| Shao, H | 1 |
| Guan, X | 1 |
| Chen, X | 2 |
| Chen, Y | 4 |
| Wei, J | 1 |
| Zhu, C | 1 |
| Wu, C | 1 |
| Moore, HB | 1 |
| Barrett, CD | 1 |
| Moore, EE | 1 |
| Jhunjhunwala, R | 1 |
| McIntyre, RC | 1 |
| Moore, PK | 1 |
| Hajizadeh, N | 1 |
| Talmor, DS | 1 |
| Sauaia, A | 1 |
| Yaffe, MB | 1 |
| Liu, C | 3 |
| Lin, Y | 1 |
| Dong, Y | 1 |
| Wu, Y | 1 |
| Bao, Y | 1 |
| Yan, H | 2 |
| Ma, J | 1 |
| Fernández-Cuadros, ME | 1 |
| Albaladejo-Florín, MJ | 1 |
| Álava-Rabasa, S | 1 |
| Usandizaga-Elio, I | 1 |
| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
| Pérez-Moro, OS | 1 |
| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
| Galli, A | 1 |
| Bognetti, P | 1 |
| Davin, A | 1 |
| Cirrincione, A | 1 |
| Ceretti, A | 1 |
| Cereda, C | 1 |
| Ceroni, M | 1 |
| Tronconi, L | 1 |
| Vitali, S | 1 |
| Guaita, A | 1 |
| Leeds, JS | 1 |
| Raviprakash, V | 1 |
| Jacques, T | 1 |
| Scanlon, N | 1 |
| Cundall, J | 1 |
| Leeds, CM | 1 |
| Riva, A | 1 |
| Gray, EH | 1 |
| Azarian, S | 1 |
| Zamalloa, A | 1 |
| McPhail, MJW | 1 |
| Vincent, RP | 1 |
| Williams, R | 1 |
| Chokshi, S | 1 |
| Patel, VC | 1 |
| Edwards, LA | 1 |
| Alqarawi, W | 1 |
| Birnie, DH | 1 |
| Golian, M | 1 |
| Nair, GM | 1 |
| Nery, PB | 1 |
| Klein, A | 1 |
| Davis, DR | 1 |
| Sadek, MM | 1 |
| Neilipovitz, D | 1 |
| Johnson, CB | 1 |
| Green, MS | 1 |
| Redpath, C | 1 |
| Miller, DC | 1 |
| Beamer, P | 1 |
| Billheimer, D | 1 |
| Subbian, V | 1 |
| Sorooshian, A | 1 |
| Campbell, BS | 1 |
| Mosier, JM | 1 |
| Novaretti, JV | 1 |
| Astur, DC | 1 |
| Cavalcante, ELB | 1 |
| Kaleka, CC | 1 |
| Amaro, JT | 1 |
| Cohen, M | 1 |
| Huang, W | 2 |
| Li, T | 1 |
| Ling, Y | 1 |
| Qian, ZP | 1 |
| Zhang, YY | 1 |
| Huang, D | 1 |
| Xu, SB | 1 |
| Liu, XH | 1 |
| Xia, L | 1 |
| Yang, Y | 3 |
| Lu, SH | 1 |
| Lu, HZ | 1 |
| Zhang, R | 2 |
| Ma, JX | 1 |
| Tang, S | 1 |
| Li, CM | 1 |
| Wan, J | 1 |
| Wang, JF | 1 |
| Ma, JQ | 1 |
| Luo, JJ | 1 |
| Chen, HY | 2 |
| Mi, SL | 1 |
| Chen, SY | 1 |
| Su, YG | 1 |
| Ge, JB | 1 |
| Milheiro, SA | 1 |
| Gonçalves, J | 1 |
| Lopes, RMRM | 1 |
| Madureira, M | 1 |
| Lobo, L | 1 |
| Lopes, A | 1 |
| Nogueira, F | 1 |
| Fontinha, D | 1 |
| Prudêncio, M | 1 |
| M Piedade, MF | 1 |
| Pinto, SN | 1 |
| Florindo, PR | 1 |
| Moreira, R | 1 |
| Castillo-Lora, J | 1 |
| Delley, MF | 1 |
| Laga, SM | 1 |
| Mayer, JM | 1 |
| Sutjarit, N | 1 |
| Thongon, N | 1 |
| Weerachayaphorn, J | 1 |
| Piyachaturawat, P | 1 |
| Suksamrarn, A | 1 |
| Suksen, K | 1 |
| Papachristou, DJ | 1 |
| Blair, HC | 1 |
| Hu, Y | 1 |
| Shen, P | 1 |
| Zeng, N | 1 |
| Wang, L | 3 |
| Yan, D | 1 |
| Cui, L | 1 |
| Yang, K | 2 |
| Zhai, C | 1 |
| Yang, M | 1 |
| Lao, X | 1 |
| Sun, J | 1 |
| Ma, N | 1 |
| Wang, S | 1 |
| Ye, W | 1 |
| Guo, P | 1 |
| Rahimi, S | 1 |
| Singh, MP | 1 |
| Gupta, J | 1 |
| Nakanishi, I | 1 |
| Ohkubo, K | 1 |
| Shoji, Y | 1 |
| Fujitaka, Y | 1 |
| Shimoda, K | 1 |
| Matsumoto, KI | 1 |
| Fukuhara, K | 1 |
| Hamada, H | 1 |
| van der Boom, T | 1 |
| Gruppen, EG | 1 |
| Lefrandt, JD | 1 |
| Connelly, MA | 1 |
| Links, TP | 1 |
| Dullaart, RPF | 1 |
| Berry, JD | 1 |
| Bedlack, R | 1 |
| Mathews, D | 1 |
| Agnese, W | 1 |
| Apple, S | 1 |
| Meloncelli, S | 1 |
| Divizia, M | 1 |
| Germani, G | 1 |
| Adefegha, SA | 1 |
| Bottari, NB | 1 |
| Leal, DB | 1 |
| de Andrade, CM | 1 |
| Schetinger, MR | 1 |
| Martínez-Velasco, A | 1 |
| Perez-Ortiz, AC | 1 |
| Antonio-Aguirre, B | 1 |
| Martínez-Villaseñor, L | 1 |
| Lira-Romero, E | 1 |
| Palacio-Pastrana, C | 1 |
| Zenteno, JC | 1 |
| Ramirez, I | 1 |
| Zepeda-Palacio, C | 1 |
| Mendoza-Velásquez, C | 1 |
| Camacho-Ordóñez, A | 1 |
| Ortiz Bibriesca, DM | 1 |
| Estrada-Mena, FJ | 1 |
| Martin, BL | 1 |
| Thompson, LC | 1 |
| Kim, YH | 2 |
| Snow, SJ | 1 |
| Schladweiler, MC | 1 |
| Phillips, P | 1 |
| Harmon, M | 1 |
| King, C | 1 |
| Richards, J | 1 |
| George, I | 1 |
| Haykal-Coates, N | 1 |
| Gilmour, MI | 1 |
| Kodavanti, UP | 1 |
| Hazari, MS | 1 |
| Farraj, AK | 1 |
| Shen, Z | 1 |
| Zou, Y | 1 |
| Gao, K | 1 |
| Lazar, S | 1 |
| Wurtzel, JGT | 1 |
| Ma, P | 1 |
| Goldfinger, LE | 1 |
| Vukelic, M | 1 |
| Laloo, A | 1 |
| Kyttaris, VC | 1 |
| Chen, R | 1 |
| Chen, J | 2 |
| Xun, J | 1 |
| Hu, Z | 1 |
| Huang, Q | 2 |
| Steinhart, C | 1 |
| Shen, Y | 1 |
| Lu, H | 1 |
| Mansuri, A | 1 |
| Lokhande, K | 1 |
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| Gaikwad, S | 1 |
| Nawani, N | 1 |
| Swamy, KV | 1 |
| Junnarkar, M | 1 |
| Pawar, S | 1 |
| Shaheen, MY | 1 |
| Basudan, AM | 1 |
| Niazy, AA | 1 |
| van den Beucken, JJJP | 1 |
| Jansen, JA | 1 |
| Alghamdi, HS | 1 |
| Gao, Q | 2 |
| Guo, X | 1 |
| Cao, Y | 1 |
| Jia, X | 1 |
| Xu, S | 1 |
| Lu, C | 2 |
| Zhu, H | 2 |
| Melku, M | 1 |
| Abebe, G | 1 |
| Teketel, A | 1 |
| Asrie, F | 1 |
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| Biadgo, B | 1 |
| Kassa, E | 1 |
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| Anlay, DZ | 1 |
| Ahmed, MFE | 1 |
| Ramadan, H | 1 |
| Seinige, D | 1 |
| Kehrenberg, C | 1 |
| Abd El-Wahab, A | 1 |
| Volkmann, N | 1 |
| Kemper, N | 1 |
| Schulz, J | 1 |
| Hu, MY | 1 |
| Wu, YN | 1 |
| McEvoy, MP | 1 |
| Wang, YF | 1 |
| Cong, WL | 1 |
| Liu, LP | 1 |
| Li, XX | 1 |
| Zhou, CL | 1 |
| Chen, WM | 1 |
| Wei, KL | 1 |
| Tung, SY | 1 |
| Shen, CH | 1 |
| Chang, TS | 1 |
| Yen, CW | 1 |
| Hsieh, YY | 1 |
| Chiu, WN | 1 |
| Hu, JH | 1 |
| Lu, SN | 1 |
| Hung, CH | 1 |
| Alakavuklar, MA | 1 |
| Fuqua, C | 1 |
| Luo, KL | 1 |
| Underwood, RS | 1 |
| Greenwald, I | 1 |
| Elashiry, MM | 1 |
| Elashiry, M | 1 |
| Zeitoun, R | 1 |
| Elsayed, R | 1 |
| Tian, F | 1 |
| Saber, SE | 1 |
| Elashry, SH | 1 |
| Tay, FR | 1 |
| Cutler, CW | 1 |
| O'Dowd, A | 1 |
| Maciel, M | 1 |
| Poole, ST | 1 |
| Jobling, MG | 1 |
| Rollenhagen, JE | 1 |
| Woods, CM | 1 |
| Sincock, SA | 1 |
| McVeigh, AL | 1 |
| Gregory, MJ | 1 |
| Maves, RC | 1 |
| Prouty, MG | 1 |
| Holmes, RK | 1 |
| Savarino, SJ | 1 |
| Mor, MK | 1 |
| Palevsky, PM | 1 |
| Kaufman, JS | 1 |
| Thiessen Philbrook, H | 1 |
| Weisbord, SD | 1 |
| Parikh, CR | 1 |
| John, CM | 1 |
| Phillips, NJ | 1 |
| Jarvis, GA | 1 |
| Zhu, Y | 1 |
| Kilburn, S | 1 |
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| Chaturvedi, S | 1 |
| Shaw, KJ | 1 |
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| Zhang, T | 1 |
| Xiao, H | 1 |
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| Nguyen, F | 1 |
| Guan, P | 1 |
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| Naraparaju, K | 1 |
| Perry, LM | 1 |
| Soberman, D | 1 |
| Pressly, BB | 1 |
| Alferiev, IS | 1 |
| Chorny, M | 1 |
| Brodeur, GM | 1 |
| Gao, X | 2 |
| Cheng, YH | 1 |
| Enten, GA | 1 |
| DeSantis, AJ | 1 |
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| Majetschak, M | 1 |
| Kim, DY | 1 |
| Choi, MJ | 1 |
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| Lee, NH | 1 |
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| Cheon, HG | 1 |
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| Saad, O | 1 |
| Ma, S | 1 |
| Ljumanovic, N | 1 |
| Khojasteh, SC | 1 |
| Kamath, AV | 1 |
| Shen, BQ | 1 |
| Cuypers, ML | 1 |
| Chanteux, H | 1 |
| Gillent, E | 1 |
| Bonnaillie, P | 1 |
| Saunders, K | 1 |
| Beckers, C | 1 |
| Delatour, C | 1 |
| Dell'Aiera, S | 1 |
| Ungell, AL | 1 |
| Nicolaï, J | 1 |
| Knapp, AK | 1 |
| Chen, A | 1 |
| Griffin-Nolan, RJ | 1 |
| Baur, LE | 1 |
| Carroll, CJW | 1 |
| Gray, JE | 1 |
| Hoffman, AM | 1 |
| Li, X | 5 |
| Post, AK | 1 |
| Slette, IJ | 1 |
| Collins, SL | 1 |
| Luo, Y | 1 |
| Smith, MD | 1 |
| Temitayo, GI | 1 |
| Olawande, B | 1 |
| Emmanuel, YO | 1 |
| Timothy, AT | 1 |
| Kehinde, O | 1 |
| Susan, LF | 1 |
| Ezra, L | 1 |
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| Desmarini, D | 1 |
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| Sorrell, TC | 1 |
| Hawthorne, WJ | 1 |
| Djordjevic, JT | 1 |
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| Wang, ZG | 1 |
| Chen, L | 1 |
| Cai, C | 1 |
| Zhang, Y | 4 |
| Ba, D | 1 |
| Wen, S | 1 |
| Tian, Q | 1 |
| Lv, W | 1 |
| Cheng, G | 1 |
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| Chen, Q | 1 |
| Choi, ES | 1 |
| Zhao, X | 3 |
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| Liu, J | 2 |
| Huang, Y | 1 |
| Kong, L | 1 |
| Yu, X | 1 |
| Feng, B | 1 |
| Liu, D | 1 |
| Zhao, B | 1 |
| Mendes, GC | 1 |
| Yuan, P | 1 |
| Ge, D | 1 |
| Wang, WM | 1 |
| Fontes, EPB | 1 |
| Li, P | 1 |
| Shan, L | 1 |
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| Jian-Bo, Z | 1 |
| Dan-Li, W | 1 |
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| Amin, SAW | 1 |
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| Hartmann, MSM | 1 |
| Vanni, JR | 1 |
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| Langaro, MC | 1 |
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| Lucivero, V | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Regeneration in Cervical Degenerative Myelopathy - a Multi-centre, Double-blind, Randomised, Placebo Controlled Trial Assessing the Efficacy of Ibudilast as an Adjuvant Treatment to Decompressive Surgery for Degenerative Cervical Myelopathy[NCT04631471] | Phase 3 | 400 participants (Anticipated) | Interventional | 2021-12-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for choline and Multiple Sclerosis
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis.
Topics: Animals; Autoimmunity; Bile Acids and Salts; Choline; Dysbiosis; Fatty Acids, Volatile; Gastrointest | 2018 |
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
[Magnetic resonance spectroscopy and its clinical applications in multiple sclerosis].
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Humans; Lactic Acid; Magnetic Resonance Spectroscopy | 2003 |
MR spectroscopy in multiple sclerosis.
Topics: Aspartic Acid; Brain Chemistry; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Multiple | 2007 |
Correlations of evoked potentials with MR imaging and MR spectroscopy in multiple sclerosis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Evoked Potentials; Evoked Potentials, Somatosensory; Evoked | 1998 |
Proton MR spectroscopy in multiple sclerosis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Disability Evaluation; Disease Progression; Energy Metaboli | 2000 |
Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy.
Topics: Animals; Aspartic Acid; Brain; Choline; Humans; Lipid Metabolism; Magnetic Resonance Imaging; Magnet | 1991 |
9 trials available for choline and Multiple Sclerosis
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
The effects of interferon beta-1a on proton MR spectroscopic imaging in patients with multiple sclerosis, a controlled study, preliminary results.
Topics: Adjuvants, Immunologic; Adult; Aspartic Acid; Biomarkers; Brain Mapping; Central Nervous System; Cho | 2008 |
The effectiveness of choline citrate infusions monitored by lymphocyte transformation test (LTT) in multiple sclerosis. A new approach to the diagnosis and treatment of the disease.
Topics: Adult; Choline; Humans; Immunologic Factors; Lymphocyte Activation; Middle Aged; Multiple Sclerosis; | 2009 |
Association between change in normal appearing white matter metabolites and intrathecal inflammation in natalizumab-treated multiple sclerosis.
Topics: Adult; Antibodies, Monoclonal, Humanized; Choline; Creatine; Female; Humans; Inflammation; Interleuk | 2012 |
Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients.
Topics: Adult; Aspartic Acid; Atrophy; Axons; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; Cre | 2003 |
Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Corpus Callosum; Creatine; Diffusion; Female; Humans; Magnetic | 2003 |
High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diagnosis, Differential; | 2008 |
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Alanine; Amino Acids; Aspartic Acid; Biomarkers; Chol | 2001 |
59 other studies available for choline and Multiple Sclerosis
| Article | Year |
|---|---|
Tumefactive demyelinating CNS lesion in a 60-year-old woman with familial Mediterranean fever.
Topics: Choline; Familial Mediterranean Fever; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Magn | 2022 |
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Topics: Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Inositol; Magnetic Resonance | 2022 |
Altered hypothalamic metabolism in early multiple sclerosis - MR spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Hypothalamus; Ino | 2019 |
Metabolites predict lesion formation and severity in relapsing-remitting multiple sclerosis.
Topics: Adult; Brain; Choline; Diffusion Tensor Imaging; Female; Glutamic Acid; Humans; Magnetic Resonance I | 2018 |
Altered Cerebrospinal Fluid Concentrations of Hydrophobic and Hydrophilic Compounds in Early Stages of Multiple Sclerosis-Metabolic Profile Analyses.
Topics: Acetone; Adult; Amino Acids; Biomarkers; Case-Control Studies; Choline; Creatinine; Female; Humans; | 2019 |
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inos | 2013 |
Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic | 2013 |
[The metabolic abnormalities in plaques of multiple sclerosis patients - the assessment in proton MR spectroscopy (1HMRS)].
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Leukoencephalopa | 2013 |
Quantification of diagnostic biomarkers to detect multiple sclerosis lesions employing (1)H-MRSI at 3T.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Choline; Creatine; Female; Glutathio | 2015 |
Metabolic changes in normal-appearing white matter in patients with neuromyelitis optica and multiple sclerosis: a comparative magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Sp | 2017 |
MR spectroscopy indicates diffuse multiple sclerosis activity during remission.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonan | 2009 |
Reduced NAA-levels in the NAWM of patients with MS is a feature of progression. A study with quantitative magnetic resonance spectroscopy at 3 Tesla.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Midd | 2010 |
Proton MRS of large multiple sclerosis lesions reveals subtle changes in metabolite T(1) and area.
Topics: Aspartic Acid; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Proto | 2010 |
Conventional and advanced magnetic resonance imaging in tumefactive demyelination.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Contrast Media; Demyelinatin | 2011 |
Correlation of diffusion and metabolic alterations in different clinical forms of multiple sclerosis.
Topics: Adult; Aspartic Acid; Choline; Diffusion; Diffusion Tensor Imaging; Humans; Image Processing, Comput | 2012 |
Tumefactive multiple sclerosis lesions under fingolimod treatment.
Topics: Aspartic Acid; Brain; Choline; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; I | 2012 |
Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectro | 2002 |
Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis.
Topics: Adult; Brain; Choline; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spect | 2002 |
Disappearing "T1 black holes" in an animal model of multiple sclerosis.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Cardiovirus Infections; Choline; Creatine; Magnetic | 2004 |
MR spectroscopy of cervical spinal cord in patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Case-Control Studies; Cervical Vertebrae; Choline; Creatine; Female; Humans; I | 2004 |
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.
Topics: Acute Disease; Adult; Brain; Choline; Chronic Disease; Female; Glutamic Acid; Humans; Inositol; Magn | 2005 |
Proton magnetic resonance spectroscopy of normal appearing white matter in familial and sporadic multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Image Processing, Computer-Assisted; | 2005 |
(1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Processing, | 2006 |
Magnetic resonance spectroscopy of memory and frontal brain region in early multiple sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Disability Evaluation; Female; Frontal Lobe; Humans; Magn | 2005 |
A simplified method to integrate metabolic images in stereotactic procedures using a PET/CT scanner.
Topics: Aged; Algorithms; Brain; Carbon Radioisotopes; Choline; Female; Fluorodeoxyglucose F18; Humans; Imag | 2005 |
Proton magnetic resonance spectroscopy of normal appearing white matter in asymptomatic relatives of multiple sclerosis patients.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resona | 2006 |
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; | 2007 |
Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS : a MRSI study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain Mapping; Case-Control Studies; Choline; Female; Hu | 2007 |
Low choline concentrations in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.
Topics: Adult; Biomarkers; Brain; Choline; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Sp | 2007 |
Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Ino | 2007 |
"Absolute" quantification in magnetic resonance spectroscopy: validation of a clinical protocol in multiple sclerosis.
Topics: Adult; Algorithms; Aspartic Acid; Biomarkers; Brain; Choline; Diagnosis, Computer-Assisted; Female; | 2007 |
Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter.
Topics: Adult; Brain Chemistry; Choline; Contrast Media; Creatine; Gadolinium; Heterocyclic Compounds; Human | 1995 |
Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Choline; Cohort Studies; Creatine; Demyelinating Dise | 1994 |
Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Mal | 1994 |
Automated processing for proton spectroscopic imaging using water reference deconvolution.
Topics: Artifacts; Aspartic Acid; Body Water; Brain; Choline; Creatine; Electronic Data Processing; Fourier | 1994 |
Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products.
Topics: Adult; Choline; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis | 1993 |
Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation.
Topics: Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Cerebrospinal Fluid; Choline; Confidence Inter | 1996 |
Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T.
Topics: Adult; Aspartic Acid; Astrocytes; Axons; Brain; Cell Membrane; Cerebral Ventricles; Choline; Creatin | 1996 |
Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis--ringlike appearances in acute plaques.
Topics: Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol | 1996 |
Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases; Brain Edema; Choline; Chronic Disease; Creatine; Demyel | 1996 |
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic | 1996 |
A study of multiple sclerosis patients with magnetic resonance spectroscopic imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Reso | 1995 |
Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Female; Gadolinium; Humans; Image Enhancement; Lipid Metabolis | 1998 |
1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study.
Topics: Adult; Brain; Choline; Creatinine; Disability Evaluation; Humans; Inositol; Interferon-beta; Magneti | 1998 |
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Huma | 1998 |
Quantitative spectroscopic imaging of the human brain.
Topics: Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Ventricles; Choline; Computer Graphics; Crea | 1998 |
Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients.
Topics: Adult; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Imagi | 1999 |
Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Biopsy, Needle; Blood-Brain Barrier; Brain; Cell Division; Choline; Dem | 1999 |
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I | 2000 |
Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magn | 2001 |
Use of choline in the treatment of ataxia associated with multiple sclerosis.
Topics: Ataxia; Choline; Double-Blind Method; Humans; Multiple Sclerosis | 1979 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis.
Topics: Choline; Chronic Disease; Creatine; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Pro | 1991 |
Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis.
Topics: Acute Disease; Adult; Aspartic Acid; Brain; Choline; Chronic Disease; Female; Humans; Lipid Metaboli | 1991 |
Human brain proton localized NMR spectroscopy in multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Resonance | 1991 |
Lipid alterations in apparently normal white matter in multiple sclerosis.
Topics: Adult; Aged; Brain; Cerebrosides; Cholesterol; Choline; Fatty Acids; Female; Humans; Inositol; Lipid | 1971 |
Fatty acid and aldehyde changes in choline- and ethanolamine-containing phospholipids in the white matter of multiple sclerosis brains.
Topics: Aldehydes; Amino Alcohols; Brain; Choline; Esters; Fatty Acids; Humans; Multiple Sclerosis; Phosphol | 1969 |