choline has been researched along with Liver Steatosis in 273 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency." | 9.16 | Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. ( Colvin, RM; Diehl, A; Guerrerio, AL; Lavine, JE; Mohan, P; Molleston, JP; Murray, KF; Scheimann, AO; Schwartz, AK; Schwimmer, JB; Torbenson, MS, 2012) |
| "Two experiments were conducted to evaluate if supplementing rumen-protected choline (RPC; Reashure, Balchem Encapsulates, Slate Hill, NY) could prevent or alleviate fatty liver in dairy cattle." | 9.12 | Supplemental choline for prevention and alleviation of fatty liver in dairy cattle. ( Bertics, SJ; Caraviello, DZ; Cooke, RF; Grummer, RR; Ramos, MH; Silva Del Río, N, 2007) |
| "Humans eating low-choline diets develop fatty liver and liver damage." | 8.88 | Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. ( Corbin, KD; Zeisel, SH, 2012) |
| "Objectives were to determine the effects of supplementing increasing amounts of choline ion on hepatic composition and mRNA abundance in pregnant dry cows subjected to a fatty liver induction protocol." | 8.31 | Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows. ( Arshad, U; Santos, JEP; Staples, CR; Tribulo, P; Zenobi, MG, 2023) |
| " We hypothesized that lower folate, choline, betaine, and glutathione (GSH) concentrations but higher total homocysteine and trimethylamine N-oxide concentrations are associated with fatty liver (FL) in postmenopausal women." | 8.12 | Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women. ( Chmurzynska, A; Muzsik-Kazimierska, A; Nikrandt, G; Szwengiel, A, 2022) |
| " Despite enzyme substitution, low pancreatic phospholipase A2 (sPLaseA2-IB) activity causes fecal loss of bile phosphatidylcholine and choline deficiency." | 8.02 | Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report. ( Bernhard, W; Graepler-Mainka, U; Grimmel, M; Haack, TB; Machann, J; Shunova, A; Utz, P, 2021) |
| "C57BL/6-GFP transgenic mice were fed with a choline-deficient diet in order to establish a fatty liver model." | 7.85 | Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. ( Aoki, H; Hasegawa, K; Hoffman, RM; Kunisada, T; Matsumoto, T; Moriwaki, H; Nakamura, M; Saji, S; Shimizu, M; Suetsugu, A, 2017) |
| "To study role of endoplasmic reticulum stress in the development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats." | 7.76 | [Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. ( Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH, 2010) |
| "Fatty liver was induced in rats by placing them on a methionine-choline deficient diet for one month." | 7.72 | Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis. ( Aeed, H; Avni, Y; Birkenfeld, S; Bruck, R; Matas, Z; Shahmurov, M; Shirin, H, 2003) |
| " Our previous studies have shown this to be caused, at least in part, by choline deficiency." | 7.69 | Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. ( Ament, ME; Buchman, AL; Dubin, MD; Gornbein, J; Jenden, DJ; Moukarzel, AA; Rice, KM; Roch, M, 1995) |
| " Addition of supplemental choline to a biotin-deficient diet decreased the biotin status of chicks and increased mortality from fatty liver and kidney syndrome (FLKS)." | 7.66 | Interrelationships between biotin, choline and other B-vitamins and the occurrence of fatty liver and kidney syndrome and sudden death syndrome in broiler chickens. ( Randall, CJ; Whitehead, CC, 1982) |
| " Experimental evidence obtained in rats suggest that the precipitous fall in maternal liver choline concentration nearing the end of pregnancy could lead to a severe reduction in the lipotropic activity of the liver." | 7.66 | Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency? ( Gwee, MC, 1982) |
| "Choline is an essential nutrient, and its deficiency causes steatohepatitis." | 5.91 | Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis. ( Abukawa, D; Ando, T; Azuma, Y; Fukuda, A; Hayashi, H; Inui, A; Kaji, S; Kasahara, M; Kusuhara, H; Mizuno, S; Mizuno, T; Nakano, S; Okamoto, T; Sabu, Y; Sakamoto, S; Shimizu, S; Suzuki, M; Takahashi, S; Tamura, R; Zen, Y, 2023) |
| "Fatty liver hemorrhagic syndrome is characterized by hepatic damage and hemorrhage impairing animal welfare in birds, which was well-known to be moderately relieved through dietary choline chloride supplementation in laying hens." | 5.51 | Dietary herbaceous mixture supplementation reduced hepatic lipid deposition and improved hepatic health status in post-peak laying hens. ( Chen, W; Du, P; Huang, Y; Liu, Z; Luo, P; Wang, Z; Zhang, H; Zhang, X; Zhu, Y, 2022) |
| "Quercetin (50 mg/kg) was given by oral route daily." | 5.38 | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. ( González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D, 2012) |
| "Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks." | 5.36 | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010) |
| "Post-Triton hyperphospholipidemia was also less pronounced in CD rats." | 5.25 | Choline-deficiency fatty liver: impaired release of hepatic triglycerides. ( Lombardi, B; Pani, P; Schlunk, FF, 1968) |
| " The dose-response relationship between feed intake, liver hemorrhagic score and liver lipid content was again demonstrated." | 5.25 | Effect of inositol, lecithin, vitamins (B12 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens. ( Polin, D; Wolford, JH, 1975) |
| "There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency." | 5.16 | Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. ( Colvin, RM; Diehl, A; Guerrerio, AL; Lavine, JE; Mohan, P; Molleston, JP; Murray, KF; Scheimann, AO; Schwartz, AK; Schwimmer, JB; Torbenson, MS, 2012) |
| "The purpose of this study was to compare the spectral characteristics of lipids, choline-containing compounds, and glutamine-glutamate complex assessed with (1)H-MR spectroscopy with the histologic findings in patients with chronic hepatitis C." | 5.13 | Evaluation of the severity of chronic hepatitis C with 3-T1H-MR spectroscopy. ( Angelico, M; Bergamini, A; Bolacchi, F; Cadioli, M; Cozzolino, V; Orlacchio, A; Simonetti, G, 2008) |
| "Two experiments were conducted to evaluate if supplementing rumen-protected choline (RPC; Reashure, Balchem Encapsulates, Slate Hill, NY) could prevent or alleviate fatty liver in dairy cattle." | 5.12 | Supplemental choline for prevention and alleviation of fatty liver in dairy cattle. ( Bertics, SJ; Caraviello, DZ; Cooke, RF; Grummer, RR; Ramos, MH; Silva Del Río, N, 2007) |
| "The objective of the study was to evaluate the dietary requirements for choline in healthy men and women and to investigate the clinical sequelae of choline deficiency." | 5.12 | Sex and menopausal status influence human dietary requirements for the nutrient choline. ( Allen, RH; daCosta, KA; Fischer, LM; Kwock, L; Lu, TS; Stabler, SP; Stewart, PW; Zeisel, SH, 2007) |
| "Humans eating diets low in choline develop fatty liver and liver damage." | 4.89 | Choline's role in maintaining liver function: new evidence for epigenetic mechanisms. ( Mehedint, MG; Zeisel, SH, 2013) |
| "Humans eating low-choline diets develop fatty liver and liver damage." | 4.88 | Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. ( Corbin, KD; Zeisel, SH, 2012) |
| "Objectives were to determine the effects of supplementing increasing amounts of choline ion on hepatic composition and mRNA abundance in pregnant dry cows subjected to a fatty liver induction protocol." | 4.31 | Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows. ( Arshad, U; Santos, JEP; Staples, CR; Tribulo, P; Zenobi, MG, 2023) |
| " We hypothesized that lower folate, choline, betaine, and glutathione (GSH) concentrations but higher total homocysteine and trimethylamine N-oxide concentrations are associated with fatty liver (FL) in postmenopausal women." | 4.12 | Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women. ( Chmurzynska, A; Muzsik-Kazimierska, A; Nikrandt, G; Szwengiel, A, 2022) |
| " Despite enzyme substitution, low pancreatic phospholipase A2 (sPLaseA2-IB) activity causes fecal loss of bile phosphatidylcholine and choline deficiency." | 4.02 | Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report. ( Bernhard, W; Graepler-Mainka, U; Grimmel, M; Haack, TB; Machann, J; Shunova, A; Utz, P, 2021) |
| " The methylation of phosphatidylethanolamine to form choline has been extensively studied in the context of fatty liver disease." | 3.96 | Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. ( da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE, 2020) |
| " To induce liver steatosis and inflammation, we fed C57/black female mice (8 weeks old) a methionine-choline deficient diet (MCD diet) for 6 weeks." | 3.96 | Automated thermal imaging for the detection of fatty liver disease. ( Balint-Lahat, N; Ben-Ari, Z; Brzezinski, RY; Finchelman, JM; Grossman, E; Hoffer, O; Leor, J; Levin-Kotler, L; Lewis, N; Naftali-Shani, N; Ovadia-Blechman, Z; Rabin, N; Safran, M; Sternfeld, A; Tepper-Shaihov, O; Unis, R; Zimmer, Y, 2020) |
| "C57BL/6-GFP transgenic mice were fed with a choline-deficient diet in order to establish a fatty liver model." | 3.85 | Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. ( Aoki, H; Hasegawa, K; Hoffman, RM; Kunisada, T; Matsumoto, T; Moriwaki, H; Nakamura, M; Saji, S; Shimizu, M; Suetsugu, A, 2017) |
| "Methionine-choline deficient (MCD) diet duration necessary for development of non-alcoholic fatty liver disease (NAFLD) and the dynamic of lipid profile and fatty acids are not completely established." | 3.80 | Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease. ( Aleksić, V; Duričić, I; Ješić-Vukićević, R; Jorgačević, B; Mladenović, DR; Radosavljević, TS; Šobajić, SS; Stanković, MN; Timić, J; Vučević, DB, 2014) |
| "In the MCD mice, aliskiren attenuated hepatic steatosis, inflammation and fibrosis." | 3.79 | Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. ( Chan, CC; Hsieh, YC; Huang, YH; Lee, KC; Lin, HC; Yang, YY, 2013) |
| "Macrovesicular and microvescular steatosis were induced in rats using methylcholine deficiency and choline deficiency diets." | 3.78 | Quantification of macrovesicular and microvesicular hepatic steatosis in rats using 3.0-T ¹H-magnetic resonance spectroscopy. ( Chang, YC; Chao, PH; Chen, CL; Cheng, YF; Chiu, TM; Lai, CY; Ou, HY; Wei, YC; Yu, CY; Yu, PC, 2012) |
| "Liver steatosis (micro/macrovesicular) was induced in adult rats fed a choline-deficient diet for 14days and compared with a control normal diet." | 3.77 | Altered distribution of caveolin-1 in early liver steatosis. ( Bonfrate, L; Calamita, G; Ferri, D; Liquori, GE; Mastrodonato, M; Mentino, D; Portincasa, P; Rossi, R, 2011) |
| " The present results suggest that the coupling of high levels of choline and low levels of methionine plays an important role in the development of insulin resistance and liver steatosis." | 3.77 | Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention. ( Bachmair, EM; Boekschoten, MV; Brennan, L; Coort, SL; Daniel, H; Evelo, C; Gibney, MJ; Keijer, J; Kleemann, R; McLoughlin, GA; Muller, M; Roos, Bd; Rubio-Aliaga, I; Sailer, M; van Erk, M; van Schothorst, EM, 2011) |
| "To study role of endoplasmic reticulum stress in the development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats." | 3.76 | [Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. ( Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH, 2010) |
| " Feeding a diet deficient in both methionine and choline (MCD) is one of the most common models of NASH, which is characterized by steatosis, mitochondrial dysfunction, hepatocellular injury, oxidative stress, inflammation, and fibrosis." | 3.76 | Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. ( Caballeria, J; Caballero, F; Elena, M; Fernández, A; Fernández-Checa, JC; Fucho, R; García-Ruiz, C; Martínez, L; Matías, N; Morales, A, 2010) |
| "To clarify the causal relationship between insulin resistance and the development of NASH, steatohepatitis was induced in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) and nondiabetic control Long-Evans Tokushima Otsuka (LETO) rats by feeding them a methionine and choline-deficient (MCD) diet." | 3.74 | Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. ( Akahori, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa, N; Misu, H; Nakanuma, Y; Ota, T; Sakurai, M; Takamura, T; Uno, M; Zen, Y, 2007) |
| "Mdr2 (+/-) and Mdr2 (+/+) mice were treated with an MCD or control diet for up to 30 days, and the severity of steatohepatitis, PEMT activity and hepatic S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH) levels were measured." | 3.73 | Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. ( Green, RM; Igolnikov, AC, 2006) |
| " In the methionine- and choline-deficient diet mouse model of steatohepatitis with CYP2E1 overexpression, insulin-induced IRS-1, IRS-2, and Akt phosphorylation were similarly decreased." | 3.73 | Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. ( Czaja, MJ; Rigoli, RM; Schattenberg, JM; Singh, R; Wang, Y, 2005) |
| "Fatty liver was induced in rats by placing them on a methionine-choline deficient diet for one month." | 3.72 | Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis. ( Aeed, H; Avni, Y; Birkenfeld, S; Bruck, R; Matas, Z; Shahmurov, M; Shirin, H, 2003) |
| "The aim of this study was to determine if a relationship exists between nonalcoholic steatohepatitis (NASH) and serum levels of free fatty acids, choline deficiency, or celiac disease." | 3.71 | Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. ( Angulo, P; Buchman, AL; Lindor, KD; Nehra, V, 2001) |
| " Our previous studies have shown this to be caused, at least in part, by choline deficiency." | 3.69 | Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. ( Ament, ME; Buchman, AL; Dubin, MD; Gornbein, J; Jenden, DJ; Moukarzel, AA; Rice, KM; Roch, M, 1995) |
| "Effects of inhibitors of arachidonic acid (AA) metabolism on the development of fatty liver, cirrhosis, glutathione-S-transferase placental form (GST-P)-positive nodules and the generation of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances (TBARS), caused by a choline-deficient, L-amino acid-defined (CDAA) diet, were examined in male Fischer 344 rats by feeding CDAA diets supplemented with the inhibitors for 12 and 30 weeks." | 3.69 | Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. ( Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T, 1996) |
| " We investigated the effect of warm ischemia and reperfusion on sinusoidal microcirculation in rats with fatty livers from a choline-deficient diet." | 3.69 | Sinusoidal flow block after warm ischemia in rats with diet-induced fatty liver. ( Hakamada, K; Konn, M; Sasaki, M; Takahashi, K; Umehara, Y, 1997) |
| " In choline-deficient Fischer 344 rats, we previously showed that fatty liver was associated with elevated hepatic DAG and sustained activation of PKC." | 3.69 | Hepatic protein kinase C is not activated despite high intracellular 1,2-sn-diacylglycerol in obese Zucker rats. ( da Costa, KA; Mar, MH; Shin, OH; Zeisel, SH, 1997) |
| "Choline deficiency, via deprivation of labile methyl groups, is associated with a greatly increased incidence of hepatocarcinoma in experimental animals." | 3.68 | Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. ( Blusztajn, JK; Cochary, EF; da Costa, KA; Garner, SC; Zeisel, SH, 1993) |
| " Experimental evidence obtained in rats suggest that the precipitous fall in maternal liver choline concentration nearing the end of pregnancy could lead to a severe reduction in the lipotropic activity of the liver." | 3.66 | Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency? ( Gwee, MC, 1982) |
| " Addition of supplemental choline to a biotin-deficient diet decreased the biotin status of chicks and increased mortality from fatty liver and kidney syndrome (FLKS)." | 3.66 | Interrelationships between biotin, choline and other B-vitamins and the occurrence of fatty liver and kidney syndrome and sudden death syndrome in broiler chickens. ( Randall, CJ; Whitehead, CC, 1982) |
| " In animal experiments, activities of these enzymes in both serum and liver homogenate were examined in rats with choline-deficient, ethionine-treated, and alcoholic fatty livers." | 3.66 | [Clinical and experimental studies on changes in lysosomal enzyme activity in fatty livers (author's transl)]. ( Yamada, J, 1978) |
| "Early effects of choline deficiency were studied in rats." | 3.64 | Diurnal changes in liver and plasma lipids of choline-deficient rats. ( Lang, JM; Rosenfeld, B, 1966) |
| "A dose-response effect of rs12325817 on the risk of choline-related organ dysfunction was observed in premenopausal women: 80%, 43%, and 13% of women with 2, 1, or 0 alleles, respectively, developed organ dysfunction." | 2.75 | Dietary choline requirements of women: effects of estrogen and genetic variation. ( da Costa, KA; Fischer, LM; Galanko, J; Kwock, L; Zeisel, SH, 2010) |
| "Choline is a conditionally essential nutrient in this population." | 2.67 | Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. ( Ament, ME; Buchman, AL; Dubin, M; Eckhert, CD; Gornbein, J; Jenden, D; Moukarzel, A; Rice, K; Roch, MH, 1992) |
| "The steatohepatitis was due to a decreased ratio of PC to phosphatidylethanolamine that caused leakage from the plasma membrane of hepatocytes." | 2.49 | Physiological roles of phosphatidylethanolamine N-methyltransferase. ( Vance, DE, 2013) |
| "Betaine is a significant determinant of plasma tHcy, particularly in case of folate deficiency, methionine load, or alcohol consumption." | 2.49 | The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. ( Obeid, R, 2013) |
| "Choline (Ch) is an important nutrient that is involved in many physiological functions." | 2.48 | Choline deprivation: an overview of the major hepatic metabolic response pathways. ( Al-Humadi, H; Al-Saigh, R; Kyriakaki, A; Liapi, C; Zarros, A, 2012) |
| "While NKT-cell involvement in steatohepatitis is debated, discrepancies may stem from varied mouse strains used, predominantly C57BL6/J with Th1-dominant responses." | 1.91 | Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice. ( Andrés-Sánchez, N; Colell, A; Cuño-Gómiz, C; de Gregorio, E; Marí, M; Morales, A; Rider, P; Tutusaus, A, 2023) |
| "Choline is an essential nutrient, and its deficiency causes steatohepatitis." | 1.91 | Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis. ( Abukawa, D; Ando, T; Azuma, Y; Fukuda, A; Hayashi, H; Inui, A; Kaji, S; Kasahara, M; Kusuhara, H; Mizuno, S; Mizuno, T; Nakano, S; Okamoto, T; Sabu, Y; Sakamoto, S; Shimizu, S; Suzuki, M; Takahashi, S; Tamura, R; Zen, Y, 2023) |
| "Choline deficiency has been well studied in the context of liver disease; however, less is known about the effects of choline supplementation in HCC." | 1.56 | Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. ( Allende, DS; Brown, AL; Conrad, K; Gromovsky, AD; Helsley, RN; Neumann, CK; Owens, AP; Tranter, M; Zhang, R, 2020) |
| "In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation." | 1.56 | Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH. ( Andreola, F; Argemi, J; Bataller, R; Caballeria, J; Cowart, LA; De Chiara, F; Fondevila, C; Fox, T; Frenguelli, L; Kester, M; Levi, A; Longato, L; Luong, TV; Massey, V; Mazza, G; Montefusco, D; Omenetti, S; Pinzani, M; Rombouts, K; Shanmugavelandy, SS; Zanieri, F, 2020) |
| "Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer." | 1.56 | A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet. ( Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M, 2020) |
| "There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents." | 1.46 | Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017) |
| "MCD diet resulted in steatohepatitis and increased miR-155 expression in total liver, hepatocytes and Kupffer cells." | 1.42 | MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. ( Bala, S; Catalano, D; Csak, T; Iracheta-Vellve, A; Kodys, K; Lippai, D; Szabo, G, 2015) |
| "Although therapeutic intervention for nonalcoholic steatohepatitis (NASH) at an early stage is important owing to the progressive nature of the disease, diagnosis using noninvasive methods remains difficult." | 1.40 | Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis. ( Fujita, K; Imajo, K; Kessoku, T; Kirikoshi, H; Mawatari, H; Nakajima, A; Nozaki, Y; Ogawa, Y; Saito, S; Sekino, Y; Shinohara, Y; Taguri, M; Takahashi, J; Tomeno, W; Toshima, G; Wada, K; Yoneda, M, 2014) |
| "Non-alcoholic fatty liver disease (NAFLD) is the commonest form of chronic liver disease in developed countries." | 1.40 | Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis. ( Azuma, T; Hoshi, N; Kawano, Y; Minami, A; Nishiumi, S; Terashima, Y; Yoshida, M, 2014) |
| "Thereafter, liver injury, liver fibrosis and hepatocellular apoptosis were quantified in liver sections." | 1.40 | Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. ( Berk, M; Dixon, L; Feldstein, AE; Inzaugarat, ME; Papouchado, BG; Povero, D; Thapaliya, S; Wree, A, 2014) |
| "This pathway is down-regulated in nonalcoholic fatty liver disease." | 1.40 | GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency. ( Baud, V; Billot, K; Collin de l'Hortet, A; Fauveau, V; Gilgenkrantz, H; Guidotti, JE; Helmy, N; Prip-Buus, C; Vons, C; Zerrad-Saadi, A; Ziol, M, 2014) |
| "Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation." | 1.40 | Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. ( Rezazadeh, A; Yazdanparast, R, 2014) |
| "Development of nonalcoholic fatty liver disease (NAFLD) occurs through initial steatosis and subsequent oxidative stress." | 1.40 | The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. ( de Luka, S; Ethuričić, I; Jorgačević, B; Mladenović, D; Ninković, M; Radosavljević, TS; Sobajić, S; Stanković, MN; Vukicevic, RJ, 2014) |
| "Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis, lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of diabetes or hyperlipidemia, all in the absence of alcohol abuse." | 1.39 | Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation. ( Matsumoto, M; Miyamae, Y; Noto, T; Oishi, Y; Takeuchi-Yorimoto, A; Yamada, A, 2013) |
| "In parallel with the elevation in AR, steatohepatitis was observed in MCD diet-fed mice, and this diet-induced steatohepatitis was significantly attenuated by lentiviral-mediated knock-down of the AR gene." | 1.39 | Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. ( Chen, J; Chen, W; Deng, T; Lin, J; Qiu, L; Shi, D; Yang, J; Yang, JY; Ying, M, 2013) |
| "Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD in which inflammation and fibrosis in the liver are noted, may eventually progress to end-stage liver disease." | 1.38 | Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease. ( Fujimoto, M; Nakanishi, Y; Nishida, T; Nomoto, K; Tabuchi, Y; Takasaki, I; Tsuneyama, K, 2012) |
| "NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in Western populations." | 1.38 | Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. ( Chaba, T; Jacobs, RL; Ling, J; Vance, DE; Zhu, LF, 2012) |
| "The mechanisms triggering nonalcoholic steatohepatitis (NASH) remain poorly defined." | 1.38 | Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. ( Hahn, YS; Landes, SG; Nguyen, V; Novobrantseva, TI; Tosello-Trampont, AC, 2012) |
| "These data indicate that low CMKLR1 in NAFLD may partly result from reduced adiponectin activity." | 1.38 | Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver. ( Bauer, S; Buechler, C; Eisinger, K; Hellerbrand, C; Higuchi, A; Schäffler, A; Walsh, K; Walter, R; Wanninger, J; Weiss, TS, 2012) |
| "Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world." | 1.38 | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. ( Camporez, JP; Eisenbarth, SC; Elinav, E; Flavell, RA; Gordon, JI; Hao, L; Henao-Mejia, J; Hoffman, HM; Jin, C; Jurczak, MJ; Kau, AL; Mehal, WZ; Shulman, GI; Strowig, T; Thaiss, CA, 2012) |
| "Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis." | 1.38 | Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012) |
| "Hyperleptinaemia plays an important role in hyper-responsiveness to MTX in NASH-cirrhotic rat livers with portal hypertension." | 1.38 | Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis. ( Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Tsai, TH; Yang, YY, 2012) |
| "Quercetin (50 mg/kg) was given by oral route daily." | 1.38 | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. ( González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D, 2012) |
| "The pathogenesis of non-alcoholic steatohepatitis is still unclear." | 1.37 | Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. ( Han, F; Kong, LB; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, SX, 2011) |
| "The pathogenesis of nonalcoholic steatohepatitis (NASH) is still unclear." | 1.36 | Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. ( Fujita, K; Inamori, M; Iwasaki, T; Kirikoshi, H; Maeyama, S; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Terauchi, Y; Wada, K; Yoneda, M, 2010) |
| "Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress." | 1.36 | Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. ( Ashford, ML; Chowdhry, S; Dillon, JF; Dinkova-Kostova, AT; Hayes, JD; Meakin, PJ; Nazmy, MH; Tsujita, T; Walsh, SV, 2010) |
| "Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks." | 1.36 | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010) |
| "Nonalcoholic steatohepatitis is characterized by the association of steatosis with hepatic cell injury, lobular inflammation and fibrosis." | 1.36 | Curcumin limits the fibrogenic evolution of experimental steatohepatitis. ( Arena, U; Caligiuri, A; Delogu, W; Galastri, S; Laffi, G; Marra, F; Milani, S; Novo, E; Parola, M; Pinzani, M; Provenzano, A; Vizzutti, F; Zamara, E, 2010) |
| "Nonalcoholic steatohepatitis (NASH) may progress to advanced fibrosis and cirrhosis." | 1.35 | Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. ( Akin, H; Atug, O; Avsar, E; Celikel, C; Eren, F; Imeryuz, N; Ozdogan, O; Ozguner, F; Tahan, G; Tahan, V; Tarcin, O; Tozun, N; Uzun, H, 2009) |
| "Steatohepatitis was induced by feeding wild-type or IL-6(-/-) mice for 5 weeks with a methionine and choline-deficient (MCD) diet." | 1.35 | IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. ( Carpentier, S; Danjoux, M; Garcia, V; Levade, T; Mas, E; Ségui, B, 2009) |
| "Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma." | 1.34 | Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. ( Akisawa, N; Hirose, A; Iwasaki, S; Masuda, K; Nozaki, Y; Oben, JA; Onishi, S; Ono, M; Saibara, T; Takahashi, M; Yoshioka, A, 2007) |
| "Choline is an important nutrient for humans and animals." | 1.34 | Choline cannot be replaced by propanolamine in mice. ( Li, Z; Vance, DE, 2007) |
| "Nonalcoholic fatty liver (NAFL) and steatohepatitis (NASH) may accompany obesity, diabetes, parenteral nutrition, jejeuno-ileal bypass, and chronic inflammatory bowel disease." | 1.33 | Glutathione-enhancing agents protect against steatohepatitis in a dietary model. ( Chen, TS; de Villiers, WJ; Im, HJ; McClain, CJ; Oz, HS, 2006) |
| "In the MCD dietary model of steatohepatitis, NF-kappaB is activated early and is an important proinflammatory mediator of lesion development, but steatohepatitis occurs independently of TNF synthesis and TNFR-1 activation." | 1.33 | NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. ( Dela Peña, A; Farrell, G; Field, J; George, J; Jones, B; Leclercq, I, 2005) |
| "Nonalcoholic steatohepatitis (NASH) may cause fibrosis, cirrhosis, and hepatocellular carcinoma (HCC); however, the exact mechanism of disease progression is not fully understood." | 1.33 | Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. ( Akahane, T; Asada, K; Fukui, H; Ikenaka, Y; Kaji, K; Kitade, M; Kojima, H; Namisaki, T; Noguchi, R; Tsujimoto, T; Uemura, M; Yamazaki, M; Yanase, K; Yoshii, J; Yoshiji, H, 2006) |
| "The MCD model of 'fibrosing steatohepatitis' replicates the histologic features of human steatohepatitis, and the sequence of steatosis, inflammatory cell injury and fibrogenesis." | 1.32 | Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. ( Farrell, G; George, J; Leclercq, I; Pera, N; Phung, N; Yun Hou, J, 2003) |
| "Choline is an essential nutrient for humans and is derived from the diet as well as from de novo synthesis involving methylation of phosphatidylethanolamine catalysed by the enzyme phosphatidylethanolamine N -methyltransferase (PEMT)." | 1.32 | Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. ( Edwards, LJ; Mar, MH; Song, J; Zeisel, SH; Zhu, X, 2003) |
| "Fatty liver is known to be associated with increased mortality and morbidity after liver resection." | 1.31 | Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats. ( Horsmans, Y; Lambotte, L; Picard, C; Saliez, A; Sempoux, C; Starkel, P; Van den Berge, V, 2002) |
| "The choline concentration was determined in plasma at baseline, 1/4, 1, 3, 6, and 12 hours, and 3 and 12 hours after the infusion ended, and in daily 24-hour urine collections." | 1.29 | Choline pharmacokinetics during intermittent intravenous choline infusion in human subjects. ( Ament, ME; Buchman, AL; Chang, AS; Jenden, DJ; Moukarzel, AA; Rice, KM; Roch, M, 1994) |
| " The dose-response relationship between feed intake, liver hemorrhagic score and liver lipid content was again demonstrated." | 1.25 | Effect of inositol, lecithin, vitamins (B12 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens. ( Polin, D; Wolford, JH, 1975) |
| "Post-Triton hyperphospholipidemia was also less pronounced in CD rats." | 1.25 | Choline-deficiency fatty liver: impaired release of hepatic triglycerides. ( Lombardi, B; Pani, P; Schlunk, FF, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 132 (48.35) | 18.7374 |
| 1990's | 13 (4.76) | 18.2507 |
| 2000's | 31 (11.36) | 29.6817 |
| 2010's | 76 (27.84) | 24.3611 |
| 2020's | 21 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, TY | 1 |
| Wu, CH | 1 |
| Chang, CY | 1 |
| Lee, FJ | 1 |
| Wang, BW | 1 |
| Doong, JY | 1 |
| Lin, YS | 1 |
| Kuo, CS | 1 |
| Huang, RS | 1 |
| Garnick, L | 1 |
| Bates, C | 1 |
| Massarsky, A | 1 |
| Spencer, P | 1 |
| Sura, P | 1 |
| Monnot, AD | 1 |
| Maier, A | 1 |
| Muzsik-Kazimierska, A | 1 |
| Szwengiel, A | 2 |
| Nikrandt, G | 1 |
| Chmurzynska, A | 2 |
| Zhu, Y | 1 |
| Zhang, X | 1 |
| Du, P | 1 |
| Wang, Z | 1 |
| Luo, P | 1 |
| Huang, Y | 2 |
| Liu, Z | 1 |
| Zhang, H | 1 |
| Chen, W | 2 |
| Arshad, U | 2 |
| Husnain, A | 1 |
| Poindexter, MB | 2 |
| Zimpel, R | 1 |
| Perdomo, MC | 1 |
| Santos, JEP | 3 |
| Zenobi, MG | 2 |
| Tribulo, P | 1 |
| Staples, CR | 2 |
| Cuño-Gómiz, C | 1 |
| de Gregorio, E | 1 |
| Tutusaus, A | 1 |
| Rider, P | 1 |
| Andrés-Sánchez, N | 1 |
| Colell, A | 1 |
| Morales, A | 3 |
| Marí, M | 1 |
| Tamura, R | 1 |
| Sabu, Y | 1 |
| Mizuno, T | 1 |
| Mizuno, S | 1 |
| Nakano, S | 2 |
| Suzuki, M | 2 |
| Abukawa, D | 1 |
| Kaji, S | 1 |
| Azuma, Y | 1 |
| Inui, A | 1 |
| Okamoto, T | 1 |
| Shimizu, S | 1 |
| Fukuda, A | 1 |
| Sakamoto, S | 1 |
| Kasahara, M | 1 |
| Takahashi, S | 1 |
| Kusuhara, H | 1 |
| Zen, Y | 2 |
| Ando, T | 1 |
| Hayashi, H | 1 |
| Brown, AL | 1 |
| Conrad, K | 1 |
| Allende, DS | 1 |
| Gromovsky, AD | 1 |
| Zhang, R | 1 |
| Neumann, CK | 1 |
| Owens, AP | 1 |
| Tranter, M | 1 |
| Helsley, RN | 1 |
| Fuchs, CD | 1 |
| Krivanec, S | 1 |
| Steinacher, D | 1 |
| Mlitz, V | 1 |
| Wahlström, A | 1 |
| Stahlman, M | 1 |
| Claudel, T | 2 |
| Scharnagl, H | 1 |
| Stojakovic, T | 1 |
| Marschall, HU | 1 |
| Trauner, M | 2 |
| Eudy, BJ | 1 |
| McDermott, CE | 1 |
| Fernandez, G | 1 |
| Mathews, CE | 1 |
| Lai, J | 1 |
| da Silva, RP | 2 |
| Zanieri, F | 1 |
| Levi, A | 1 |
| Montefusco, D | 1 |
| Longato, L | 1 |
| De Chiara, F | 1 |
| Frenguelli, L | 1 |
| Omenetti, S | 1 |
| Andreola, F | 1 |
| Luong, TV | 1 |
| Massey, V | 1 |
| Caballeria, J | 2 |
| Fondevila, C | 1 |
| Shanmugavelandy, SS | 1 |
| Fox, T | 1 |
| Mazza, G | 1 |
| Argemi, J | 1 |
| Bataller, R | 1 |
| Cowart, LA | 1 |
| Kester, M | 1 |
| Pinzani, M | 2 |
| Rombouts, K | 1 |
| Brzezinski, RY | 1 |
| Levin-Kotler, L | 1 |
| Rabin, N | 1 |
| Ovadia-Blechman, Z | 1 |
| Zimmer, Y | 1 |
| Sternfeld, A | 1 |
| Finchelman, JM | 1 |
| Unis, R | 1 |
| Lewis, N | 1 |
| Tepper-Shaihov, O | 1 |
| Naftali-Shani, N | 1 |
| Balint-Lahat, N | 1 |
| Safran, M | 1 |
| Ben-Ari, Z | 1 |
| Grossman, E | 1 |
| Leor, J | 1 |
| Hoffer, O | 1 |
| Sugimoto, M | 1 |
| Hamada, T | 1 |
| Wakabayasi, M | 1 |
| Yoshioka, T | 1 |
| Kato, H | 1 |
| Konishi, H | 1 |
| Nagai, R | 1 |
| Numata, Y | 1 |
| Igarashi, Y | 1 |
| Yukioka, H | 1 |
| Suzuki-Kemuriyama, N | 1 |
| Abe, A | 1 |
| Uno, K | 1 |
| Ogawa, S | 2 |
| Watanabe, A | 1 |
| Sano, R | 1 |
| Yuki, M | 1 |
| Miyajima, K | 1 |
| Nakae, D | 2 |
| Gámez-Belmonte, R | 1 |
| Tena-Garitaonaindia, M | 1 |
| Hernández-Chirlaque, C | 1 |
| Córdova, S | 1 |
| Ceacero-Heras, D | 1 |
| de Medina, FS | 1 |
| Martínez-Augustin, O | 1 |
| Lin, CW | 1 |
| Huang, TW | 1 |
| Peng, YJ | 1 |
| Lin, YY | 1 |
| Mersmann, HJ | 1 |
| Ding, ST | 1 |
| Zhang, J | 1 |
| Jiang, D | 1 |
| Lin, S | 1 |
| Cheng, Y | 1 |
| Pan, J | 1 |
| Ding, W | 1 |
| Chen, Y | 1 |
| Fan, J | 1 |
| Bernhard, W | 1 |
| Shunova, A | 1 |
| Machann, J | 1 |
| Grimmel, M | 1 |
| Haack, TB | 1 |
| Utz, P | 1 |
| Graepler-Mainka, U | 1 |
| Młodzik-Czyżewska, MA | 1 |
| Malinowska, AM | 1 |
| Di Pasqua, LG | 2 |
| Berardo, C | 2 |
| Cagna, M | 1 |
| Mannucci, B | 1 |
| Milanesi, G | 2 |
| Croce, AC | 2 |
| Ferrigno, A | 3 |
| Vairetti, M | 3 |
| Nicholls, HT | 1 |
| Hornick, JL | 1 |
| Cohen, DE | 1 |
| Nakamura, M | 1 |
| Suetsugu, A | 2 |
| Hasegawa, K | 1 |
| Matsumoto, T | 1 |
| Aoki, H | 1 |
| Kunisada, T | 1 |
| Shimizu, M | 1 |
| Saji, S | 1 |
| Moriwaki, H | 1 |
| Hoffman, RM | 1 |
| Pierce, AA | 1 |
| Duwaerts, CC | 1 |
| Siao, K | 1 |
| Mattis, AN | 1 |
| Goodsell, A | 1 |
| Baron, JL | 1 |
| Maher, JJ | 2 |
| Stellavato, A | 1 |
| Pirozzi, AVA | 1 |
| de Novellis, F | 1 |
| Scognamiglio, I | 1 |
| Vassallo, V | 1 |
| Giori, AM | 1 |
| De Rosa, M | 1 |
| Schiraldi, C | 1 |
| Scheffler, TL | 1 |
| Zuniga, JE | 1 |
| Campagna, SR | 1 |
| Castro Gonzalez, HF | 1 |
| Farmer, AT | 1 |
| Barton, BA | 1 |
| May, T | 1 |
| Klatt, KC | 1 |
| Smith, J | 1 |
| Castro, E | 1 |
| Manary, M | 1 |
| Caudill, MA | 2 |
| Jahoor, F | 1 |
| Fiorotto, ML | 1 |
| Pogribny, IP | 2 |
| Kutanzi, K | 2 |
| Melnyk, S | 2 |
| de Conti, A | 2 |
| Tryndyak, V | 2 |
| Montgomery, B | 1 |
| Pogribna, M | 1 |
| Muskhelishvili, L | 1 |
| Latendresse, JR | 2 |
| James, SJ | 1 |
| Beland, FA | 2 |
| Rusyn, I | 2 |
| Takeuchi-Yorimoto, A | 1 |
| Noto, T | 1 |
| Yamada, A | 1 |
| Miyamae, Y | 1 |
| Oishi, Y | 1 |
| Matsumoto, M | 1 |
| Mehedint, MG | 2 |
| Zeisel, SH | 10 |
| Imajo, K | 1 |
| Yoneda, M | 2 |
| Fujita, K | 2 |
| Kessoku, T | 1 |
| Tomeno, W | 1 |
| Ogawa, Y | 1 |
| Shinohara, Y | 1 |
| Sekino, Y | 1 |
| Mawatari, H | 1 |
| Nozaki, Y | 3 |
| Kirikoshi, H | 2 |
| Taguri, M | 1 |
| Toshima, G | 1 |
| Takahashi, J | 1 |
| Saito, S | 2 |
| Wada, K | 2 |
| Nakajima, A | 2 |
| Xu, L | 1 |
| Liu, B | 1 |
| Liu, X | 1 |
| Zhang, SW | 1 |
| Xin, XG | 1 |
| Zheng, JZ | 1 |
| Shimozono, R | 1 |
| Asaoka, Y | 1 |
| Yoshizawa, Y | 1 |
| Aoki, T | 1 |
| Noda, H | 1 |
| Yamada, M | 1 |
| Kaino, M | 1 |
| Mochizuki, H | 1 |
| Lee, JT | 1 |
| Pao, LH | 1 |
| Hsiong, CH | 1 |
| Huang, PW | 1 |
| Shih, TY | 1 |
| Yoa-Pu Hu, O | 1 |
| McKee, C | 1 |
| Soeda, J | 1 |
| Asilmaz, E | 1 |
| Sigalla, B | 1 |
| Morgan, M | 1 |
| Sinelli, N | 1 |
| Roskams, T | 1 |
| Oben, JA | 2 |
| Obeid, R | 1 |
| Qiu, L | 1 |
| Lin, J | 1 |
| Ying, M | 1 |
| Yang, J | 1 |
| Deng, T | 1 |
| Chen, J | 1 |
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| Lee, KC | 1 |
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| Yang, YY | 2 |
| Hsieh, YC | 1 |
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| Lin, HC | 2 |
| Stanković, MN | 2 |
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| de Luka, S | 1 |
| Vukicevic, RJ | 1 |
| Radosavljević, TS | 2 |
| Al Rajabi, A | 1 |
| Castro, GS | 1 |
| Nelson, RC | 1 |
| Thiesen, A | 1 |
| Vannucchi, H | 1 |
| Vine, DF | 1 |
| Proctor, SD | 2 |
| Field, CJ | 1 |
| Curtis, JM | 1 |
| Jacobs, RL | 4 |
| Rezazadeh, A | 1 |
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| Mayer, D | 1 |
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| Luong, R | 1 |
| Sullivan, EV | 1 |
| Pfefferbaum, A | 1 |
| HULT, H | 1 |
| Takahashi, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Human Requirements for the Nutrient Choline[NCT00065546] | 43 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD[NCT05200156] | 100 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | |||
| The Role of Microbiome Reprogramming on Liver Fat Accumulation[NCT03914495] | 57 participants (Actual) | Interventional | 2019-05-21 | Terminated (stopped due to PI carefully considered multiple factors and decided to close study to any further enrollment.) | |||
| Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan[NCT04671186] | 47 participants (Actual) | Interventional | 2020-09-07 | Completed | |||
| Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery[NCT03391401] | 204 participants (Actual) | Observational | 2018-03-01 | Completed | |||
| Clinical Research Network in Nonalcoholic Steatohepatitis: Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)[NCT00063635] | Phase 3 | 173 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Clinical Research Network in Nonalcoholic Steatohepatitis: Pioglitazone vs. Vitamin E vs. Placebo for the Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS)[NCT00063622] | Phase 3 | 247 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Effects of Alpha-glycerylphosphorylcholine on Physical and Cognitive Performances in Varsity Volleyball Players[NCT02886130] | 28 participants (Actual) | Interventional | 2016-08-29 | Completed | |||
| Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People[NCT02837367] | 600 participants (Anticipated) | Interventional | 2016-09-30 | Recruiting | |||
| Expanded Access Use of Omegaven® in the Treatment of Parenteral Nutrition Induced Liver Injury in Children[NCT02925520] | 0 participants | Expanded Access | No longer available | ||||
| Compassionate Use of an Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants[NCT00738101] | 293 participants (Actual) | Interventional | 2008-09-30 | Completed | |||
| Research Study of an Intravenous Fat Emulsion Comprised of Fish Oils (Omegaven) in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury[NCT01089426] | 90 participants (Actual) | Interventional | 2008-09-30 | Completed | |||
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | kg/m-squared (Mean) |
|---|---|
| Metformin | 1.3 |
| Vitamin E | 2.1 |
| Placebo | 1.9 |
Histological activity was assessed using the NAFLD activity score on a scale of 0 to 8, with higher scores indicating more severe disease; the components of this measure include steatosis (0-3), lobular inflammation (0-3), and hepatocellular ballooning (0-2). (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | -1.1 |
| Vitamin E | -1.8 |
| Placebo | -0.7 |
Change in self-reported QOL physical health Pediatric Quality of Life Inventory (version 4.0) scores were recorded to range from 0 to 100 with increasing scores indicating better quality of life. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | 4.0 |
| Vitamin E | 6.0 |
| Placebo | 5.6 |
Change in self-reported QOL physical health Pediatric Quality of Life Inventory (version 4.0) scores were recorded to range from 0 to 100 with increasing scores indicating better quality of life. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | 5.4 |
| Vitamin E | 7.6 |
| Placebo | 5.4 |
(NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | IU/L (Mean) |
|---|---|
| Metformin | -21.5 |
| Vitamin E | -22.8 |
| Placebo | -20.4 |
Change in alpha-Tocopherol (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | mg/L (Mean) |
|---|---|
| Metformin | -0.5 |
| Vitamin E | 9.4 |
| Placebo | -0.9 |
Ballooning is assessed on a scale of 0 to 2 with higher scores indicating more severe ballooning. This secondary outcome measure is the number of participants that experienced a decrease in ballooning score at 96 weeks compared to baseline, which indicates improvement in ballooning. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 22 |
| Vitamin E | 22 |
| Placebo | 10 |
Fibrosis is assessed on a scale of 0 to 4 with higher scores indicating more severe fibrosis. This secondary outcome measure is the number of participants that experienced a decrease in fibrosis score at 96 weeks compared to baseline, which indicates improvement in fibrosis. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 22 |
| Vitamin E | 18 |
| Placebo | 19 |
Lobular inflammation is assessed on a scale of 0 to 3 with higher scores indicating more severe lobular inflammation. This secondary outcome measure is the number of participants that experienced a decrease in lobular inflammation score at 96 weeks compared to baseline, which indicates improvement in lobular inflammation. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 23 |
| Vitamin E | 22 |
| Placebo | 20 |
Steatosis is assessed on a scale of 0 to 3 with higher scores indicating more severe steatosis. This secondary outcome measure is the number of participants that experienced a decrease in steatosis score at 96 weeks compared to baseline, which indicates improvement in steatosis. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 26 |
| Vitamin E | 27 |
| Placebo | 19 |
The primary outcome was sustained reduction in ALT level, defined as 50% or less of the baseline level or 40 IU/L or less at each visit from 48 to 96 weeks of treatment. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 9 |
| Vitamin E | 15 |
| Placebo | 10 |
Fibrosis is assessed on a scale of 0 to 4 with higher scores indicating more severe fibrosis. This secondary outcome measure is the number of participants that experienced a decrease in fibrosis score, which indicates improvement in fibrosis. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 31 |
| Vitamin E | 33 |
| Placebo | 22 |
Hepatocellular ballooning is assessed on a scale of 0 to 2 with higher scores indicating more severe hepatocellular ballooning. This secondary outcome measure is the number of participants that experienced a decrease in hepatocellular ballooning score, which indicates improvement in hepatocellular ballooning. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 31 |
| Vitamin E | 40 |
| Placebo | 21 |
Lobular inflammation is assessed on a scale of 0 to 3 with higher scores indicating more severe lobular inflammation. This secondary outcome measure is the number of participants that experienced a decrease in lobular inflammation score, which indicates improvement in lobular inflammation. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 41 |
| Vitamin E | 43 |
| Placebo | 25 |
Total nonalcoholic fatty liver disease (NAFLD) activity was assessed on a scale of 0 to 8, with higher scores indicating more severe disease; the components of this measure include steatosis (assessed on a scale of 0 to 3), lobular inflammation (assessed on a scale of 0 to 3), and hepatocellular ballooning (assessed on a scale of 0 to 2). The primary outcome was an improvement in histological findings from baseline to 96 weeks, which required an improvement by 1 or more points in the hepatocellular ballooning score; no increase in the fibrosis score; and either a decrease in the activity score for nonalcoholic fatty liver disease to a score of 3 or less or a decrease in the activity score of at least 2 points, with at least a 1-point decrease in either the lobular inflammation or steatosis score. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 27 |
| Vitamin E | 36 |
| Placebo | 16 |
Steatosis is assessed on a scale of 0 to 3 with higher scores indicating more severe steatosis. This secondary outcome measure is the number of participants that experienced a decrease in steatosis score, which indicates improvement in steatosis. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 48 |
| Vitamin E | 43 |
| Placebo | 22 |
The criteria for nonalcoholic steatohepatitis was definite or possible steatohepatitis (assessed by a pathologist) with an activity score of 5 or more, or definite steatohepatitis (confirmed by two pathologists) with an activity score of 4. This secondary outcome measure is the number of participants who met this definition at baseline and did not meet this definition after 96 weeks of treatment and thus had a resolution of steatohepatitis. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 33 |
| Vitamin E | 29 |
| Placebo | 15 |
To describe proportion of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | Participants (Count of Participants) |
|---|---|
| Fish Oil Emulsion Arm | 30 |
To describe number and percentage of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: Anytime from initiation of study to discharge from the hospital.
| Intervention | Participants (Count of Participants) |
|---|---|
| Fish Oil Emulsion Arm | 40 |
The Z-score indicated the number of standard deviations away from the mean. A weight Z-score of 0 is equal to the mean. A weight Z-score of ≤ -2 indicates an underweight status, while a weight Z-score of ≥ 2 indicates overweight or obese status. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | z-score (Mean) |
|---|---|
| Fish Oil Emulsion Arm | -1.48 |
To describe the number and percentage of infants who required liver or multi-visceral transplant. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | Participants (Count of Participants) |
|---|---|
| Fish Oil Emulsion Arm | 2 |
Time in days from the initiation of fish oil emulsions (initiation of study) until resolution of cholestasis as defined by serum conjugated bilirubin≤ 2 mg/dL prior to EOS (end of study). (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | Days (Mean) |
|---|---|
| Fish Oil Emulsion Arm | 38.02 |
11 reviews available for choline and Liver Steatosis
| Article | Year |
|---|---|
Dose and exposure route analyses inform relationships between liver steatosis and 2-amino-2-methyl-1-propanol: Implications for hazard characterization.
Topics: Adenosine Monophosphate; Animals; Chemical and Drug Induced Liver Injury; Choline; Fatty Liver; Huma | 2022 |
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.
Topics: Animals; Choline; Diet; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Folic Acid; Gene Expressi | 2013 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Mo | 2013 |
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.
Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic | 2012 |
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.
Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic | 2012 |
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.
Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic | 2012 |
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.
Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic | 2012 |
Choline deprivation: an overview of the major hepatic metabolic response pathways.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Humans; Liver; Liver Diseases | 2012 |
Physiological roles of phosphatidylethanolamine N-methyltransferase.
Topics: Animals; Choline; Diet, High-Fat; Endoplasmic Reticulum; Estrogens; Fatty Liver; Humans; Liver; Mice | 2013 |
Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology.
Topics: Animals; Choline; Fatty Liver; Gene Expression Regulation, Enzymologic; Humans; Insulin; Liver; Mice | 2007 |
Nutritional and management strategies for the prevention of fatty liver in dairy cattle.
Topics: Animal Nutritional Physiological Phenomena; Animals; Cattle; Cattle Diseases; Choline; Dietary Suppl | 2008 |
Essential nature of choline with implications for total parenteral nutrition.
Topics: Administration, Oral; Choline; Clinical Trials as Topic; Dietetics; Dose-Response Relationship, Drug | 1997 |
[Physiopathology of ethylic steatosis].
Topics: Alcohol Oxidoreductases; Alcoholism; Animals; Choline; Choline Deficiency; Dogs; Ethanol; Fatty Live | 1972 |
Alcoholic fatty liver.
Topics: Adult; Alcoholism; Animals; Child; Choline; Diet; Dietary Fats; Dietary Proteins; Drug Synergism; Et | 1969 |
8 trials available for choline and Liver Steatosis
| Article | Year |
|---|---|
Dietary herbaceous mixture supplementation reduced hepatic lipid deposition and improved hepatic health status in post-peak laying hens.
Topics: Animal Feed; Animals; Antioxidants; Chickens; Cholesterol; Choline; Diet; Dietary Supplements; Fatty | 2022 |
Dietary choline requirements of women: effects of estrogen and genetic variation.
Topics: Aged; Alleles; Choline; Choline Deficiency; Diet; Estrogen Replacement Therapy; Estrogens; Estrogens | 2010 |
Dietary choline requirements of women: effects of estrogen and genetic variation.
Topics: Aged; Alleles; Choline; Choline Deficiency; Diet; Estrogen Replacement Therapy; Estrogens; Estrogens | 2010 |
Dietary choline requirements of women: effects of estrogen and genetic variation.
Topics: Aged; Alleles; Choline; Choline Deficiency; Diet; Estrogen Replacement Therapy; Estrogens; Estrogens | 2010 |
Dietary choline requirements of women: effects of estrogen and genetic variation.
Topics: Aged; Alleles; Choline; Choline Deficiency; Diet; Estrogen Replacement Therapy; Estrogens; Estrogens | 2010 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Supplemental choline for prevention and alleviation of fatty liver in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Choline; Dairying; Dietary S | 2007 |
Sex and menopausal status influence human dietary requirements for the nutrient choline.
Topics: Adolescent; Adult; Aged; Choline; Choline Deficiency; Dose-Response Relationship, Drug; Fatty Liver; | 2007 |
Evaluation of the severity of chronic hepatitis C with 3-T1H-MR spectroscopy.
Topics: Adult; Aged; Choline; Fatty Liver; Female; Glutamic Acid; Glutamine; Hepatitis C, Chronic; Humans; L | 2008 |
Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients.
Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Carnitine; Choline; Choline Deficiency; Fat | 1992 |
[Comparative therapy of fatty liver].
Topics: Adolescent; Adult; Aged; Choline; Diet, Diabetic; Fatty Liver; Female; Humans; Hypoglycemic Agents; | 1970 |
254 other studies available for choline and Liver Steatosis
| Article | Year |
|---|---|
Optimal Dietary Intake Composition of Choline and Betaine Is Associated with Minimized Visceral Obesity-Related Hepatic Steatosis in a Case-Control Study.
Topics: Adiposity; Aged; Betaine; Biomarkers; Body Composition; Case-Control Studies; Choline; Diet Records; | 2022 |
Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women.
Topics: Betaine; Biomarkers; Choline; Fatty Liver; Female; Folic Acid; Glutathione; Homocysteine; Humans; Po | 2022 |
Effect of source and amount of rumen-protected choline on hepatic metabolism during induction of fatty liver in dairy cows.
Topics: Animals; Cattle; Cattle Diseases; Cholesterol; Choline; Diet; Dietary Supplements; Fatty Acids; Fatt | 2023 |
Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows.
Topics: Animals; Cattle; Choline; Diet; Dietary Supplements; Fatty Liver; Female; Glycogen; Lactation; Liver | 2023 |
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice.
Topics: Animals; Choline; Diet, High-Fat; Fatty Liver; Female; Fibrosis; Humans; Inflammation; Liver Cirrhos | 2023 |
Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis.
Topics: Adenosine Triphosphatases; Animals; Child; Choline; Choline Deficiency; Fatty Liver; Female; Gastroi | 2023 |
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice.
Topics: Animals; Betaine; Choline; Diet, High-Fat; Dietary Supplements; DNA, Mitochondrial; Fatty Liver; Gen | 2020 |
Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Choline; Di | 2020 |
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; | 2020 |
Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH.
Topics: Adenylate Kinase; Animals; Antioxidants; Apoptosis; Cell Proliferation; Ceramides; Choline; Diet; Di | 2020 |
Automated thermal imaging for the detection of fatty liver disease.
Topics: Algorithms; Animals; Automation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Li | 2020 |
Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet.
Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Choline; Diet, High-Fat; Fatty Liver; | 2020 |
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-F | 2020 |
Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.
Topics: Alkaline Phosphatase; Alleles; Animals; Choline; Choline Deficiency; Diet; Diet, High-Fat; Disease M | 2020 |
A novel chicken model of fatty liver disease induced by high cholesterol and low choline diets.
Topics: Animals; Chickens; Cholesterol; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Hyperlip | 2021 |
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Hep G2 Cells; Humans; Inflammati | 2021 |
Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report.
Topics: Child, Preschool; Choline; Choline Deficiency; Cystic Fibrosis; Fatty Liver; Female; Humans; Young A | 2021 |
Comparison of Associations between One-Carbon Metabolism, Lipid Metabolism, and Fatty Liver Markers in Normal-Weight and Overweight People Aged 20-40 Years.
Topics: Adult; Betaine; Carbon; Choline; Fatty Liver; Humans; Lipid Metabolism; Overweight; Phosphatidyletha | 2021 |
Long-term cold storage preservation does not affect fatty livers from rats fed with a methionine and choline deficient diet.
Topics: Animals; Choline; Choline Deficiency; Diet; Fatty Liver; Liver; Male; Methionine; Rats; Rats, Wistar | 2021 |
Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
Topics: Animal Feed; Animals; Choline; Diet; Fatty Liver; Gene Expression Regulation; Lipids; Liver; Methion | 2017 |
Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment.
Topics: Animals; Ascites; Bone Marrow; Cancer-Associated Fibroblasts; Cell Line, Tumor; Choline; Choline Def | 2017 |
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
Topics: Adipose Tissue; Animals; CD18 Antigens; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Hep | 2017 |
In vitro assessment of nutraceutical compounds and novel nutraceutical formulations in a liver-steatosis-based model.
Topics: Choline; Curcumin; Dietary Supplements; Docosahexaenoic Acids; Drug Combinations; Drug Compounding; | 2018 |
Feeding increasing amounts of ruminally protected choline decreased fatty liver in nonlactating, pregnant Holstein cows in negative energy status.
Topics: Animals; Cattle; Cattle Diseases; Choline; Diet; Fatty Liver; Female; Liver | 2018 |
Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline; Dietary Supplements; Dise | 2018 |
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.
Topics: Animals; Carbon; Choline; Choline Deficiency; Cystathionine beta-Synthase; Disease Models, Animal; D | 2013 |
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.
Topics: Amino Acids; Animals; Choline; Choline Deficiency; Dietary Supplements; Fatty Liver; Iron; Liver Cir | 2013 |
Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Case-Control Studies; Choline; Fasting; Fatty L | 2014 |
3.0 T proton magnetic resonance spectroscopy of the liver: quantification of choline.
Topics: Adult; Age Factors; Aged; Biomarkers; Body Mass Index; Choline; Fatty Liver; Female; Humans; Lipids; | 2013 |
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Antioxidants; Binding Sites; Cell Line; Choline; Die | 2013 |
Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases.
Topics: Animals; Choline; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Diet; Enzyme Assays; Fatty | 2013 |
Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis.
Topics: Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Apoptosis; Choline; Culture Media; Disea | 2013 |
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.
Topics: Aldehyde Reductase; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Female; Interleukin-6; M | 2013 |
Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet.
Topics: Amides; Angiotensin II; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Fumarates; Immunoenz | 2013 |
The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD.
Topics: Animals; Choline; Diet; Fatty Acids, Nonesterified; Fatty Liver; Humans; Lipid Peroxidation; Liver; | 2014 |
Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet.
Topics: Animals; Cholesterol; Cholesterol Esters; Choline; Diet, High-Fat; Fatty Liver; Lipid Metabolism; Li | 2014 |
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes.
Topics: Animals; Antioxidants; Ascorbic Acid; Chelating Agents; Choline; Diet; Ethylenediamines; Fatty Liver | 2014 |
Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease.
Topics: Animals; Choline; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes | 2014 |
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
Topics: Adipogenesis; Adipose Tissue; Animals; Choline; Disease Models, Animal; Fatty Acids; Fatty Acids, No | 2014 |
GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency.
Topics: Animals; Blotting, Western; Cell Proliferation; Choline; Diet; Down-Regulation; ErbB Receptors; Fatt | 2014 |
Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.
Topics: Animals; Antigens, Ly; Apoptosis; Caspase 3; Choline; Collagen; Dose-Response Relationship, Drug; Fa | 2014 |
Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis.
Topics: Animals; Choline; Diet; Fatty Liver; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice, Inb | 2014 |
Standardized Salvia miltiorrhiza extract suppresses hepatic stellate cell activation and attenuates steatohepatitis induced by a methionine-choline deficient diet in mice.
Topics: Animals; Choline; Diet; Fatty Liver; Hepatic Stellate Cells; Humans; Hydrogen Peroxide; Male; Methio | 2014 |
Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism.
Topics: Animals; Carbon; Carnitine O-Palmitoyltransferase; Cholesterol; Choline; Choline Deficiency; Creatin | 2015 |
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Choline; Diet; Disease Models, Animal; F | 2015 |
In Situ Evaluation of Oxidative Stress in Rat Fatty Liver Induced by a Methionine- and Choline-Deficient Diet.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Glutathione; Glycoge | 2016 |
Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice.
Topics: Animals; Choline; Diet; Dietary Fats; Dietary Sucrose; Dietary Supplements; Fatty Liver; Feeding Beh | 2016 |
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver | 2016 |
Editor's Highlight: Perfluorooctane Sulfonate-Choline Ion Pair Formation: A Potential Mechanism Modulating Hepatic Steatosis and Oxidative Stress in Mice.
Topics: Alkanesulfonic Acids; Animals; Choline; Dose-Response Relationship, Drug; Fatty Liver; Fluorocarbons | 2016 |
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H | 2017 |
A compromised liver alters polychlorinated biphenyl-mediated toxicity.
Topics: Adipokines; Animals; Aroclors; Biomarkers; Blood Glucose; Cardiovascular Diseases; Choline; Diet; Di | 2017 |
In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage.
Topics: Animals; Basal Ganglia; Choline; Ethanol; Fatty Liver; Glutamic Acid; Glutamine; Glycogen Storage Di | 2009 |
Steatosis hepatis treated with choline chloria.
Topics: Choline; Fatty Liver | 1947 |
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model.
Topics: Amino Acids; Animals; Blotting, Western; Choline; Choline Deficiency; Diet; Disease Models, Animal; | 2010 |
Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats.
Topics: Animals; Apoptosis; Biomarkers; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Glutathio | 2009 |
Curcumin limits the fibrogenic evolution of experimental steatohepatitis.
Topics: Actins; Alanine Transaminase; Animals; CD11b Antigen; Cells, Cultured; Chemokine CCL2; Choline; Chol | 2010 |
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
Topics: Animals; Choline; Cyclooxygenase 2; Disease Progression; Fatty Liver; Food, Formulated; Interleukin- | 2010 |
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.
Topics: Animal Feed; Animals; Choline; Choline Deficiency; Disease Progression; Fatty Liver; Lipid Peroxidat | 2010 |
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Apoptosis; Choline; Disease Models, Animal; Fatty Liver; Inflammation; Interle | 2009 |
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Inflammation; Liver Ci | 2010 |
Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice.
Topics: Alanine Transaminase; Animals; Blood Coagulation; Blood Coagulation Factors; Chemokine CCL2; Choline | 2010 |
[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats].
Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Choline; Choline Deficiency; Diet; Disease Models, | 2010 |
Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.
Topics: Alanine Transaminase; Animals; Choline; Choline Deficiency; Diet; Fatty Liver; Genes; Interleukin-6; | 2010 |
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.
Topics: Animal Feed; Animals; Ceramides; Choline; Fatty Liver; Glutathione; Inflammation; Lipids; Male; Meth | 2010 |
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
Topics: Animals; Betaine; Choline; Diet; Dietary Fats; Dietary Supplements; Energy Metabolism; Fatty Liver; | 2010 |
Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice.
Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Antioxidants; Carnitine O-Palmitoyltransferase; Choline; | 2010 |
A close association of abnormal iron metabolism with steatosis in the mice fed a choline-deficient diet.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Gene Expression Regulation; Iron; Lipid Metabolis | 2010 |
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S- | 2010 |
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice.
Topics: Adenoviridae; Anilides; Animals; beta-Galactosidase; Choline; Diet; Fatty Liver; Genetic Vectors; In | 2011 |
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline; Choline Deficiency; | 2011 |
Altered distribution of caveolin-1 in early liver steatosis.
Topics: Animals; Caveolin 1; Choline; Diet; Fatty Liver; Immunoblotting; Male; Rats; Rats, Wistar; Statistic | 2011 |
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention.
Topics: Animals; Blood Glucose; Carbon; Cholesterol; Choline; Dietary Fats; Fatty Liver; Hyperglycemia; Insu | 2011 |
Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice.
Topics: Adenosine Triphosphate; Animals; Choline; Chromatin Immunoprecipitation; Diet; Ethionine; Fatty Live | 2011 |
Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver.
Topics: Animals; Betaine; Choline; Dietary Fats; Dietary Sucrose; Dietary Supplements; Disease Models, Anima | 2011 |
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis.
Topics: Activating Transcription Factor 6; Animal Feed; Animals; Choline; Choline Deficiency; Cytokines; Dia | 2011 |
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Carbon; Carcinoma, Hepatocellular; Choline; Fatty | 2011 |
Impact of CD1d deficiency on metabolism.
Topics: Animals; Antigens, CD1d; Body Weight; Chemokine CXCL16; Chemokine CXCL6; Choline; Diet, High-Fat; Fa | 2011 |
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice.
Topics: Animals; Choline; Choline-Phosphate Cytidylyltransferase; Dietary Fats; Dietary Supplements; Disease | 2012 |
Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver.
Topics: Adiponectin; Aged; Animals; Bile Ducts; Choline; Diet; Fatty Liver; Female; Hepatic Stellate Cells; | 2012 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Quantification of macrovesicular and microvesicular hepatic steatosis in rats using 3.0-T ¹H-magnetic resonance spectroscopy.
Topics: Animals; Area Under Curve; Biomarkers; Biopsy; Choline; Choline Deficiency; Disease Models, Animal; | 2012 |
Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease.
Topics: Amino Acids; Animals; Choline; Diet; Fatty Liver; Galectin 3; Gene Expression Profiling; Gene Regula | 2012 |
Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Benzofurans; Choline; Clodronic Acid; Diet, High-Fa | 2012 |
Hepatic injury due to combined choline-deprivation and thioacetamide administration: an experimental approach to liver diseases.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2012 |
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Topics: Animal Feed; Animals; Choline; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; DNA Damage; | 2012 |
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase | 2012 |
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intracellular Signa | 2013 |
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production.
Topics: Animals; Chemokine CCL2; Chemokine CXCL10; Choline; Diet; Disease Models, Animal; Fatty Liver; Femal | 2012 |
A brief history of choline.
Topics: Acetylcholine; Animals; Bile; Choline; Dogs; Fatty Liver; History, 19th Century; History, 20th Centu | 2012 |
Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Humans; Interleukin-6; Liver; Male; Methionine; M | 2013 |
Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Carbon; Choline; Fatty Liver; Genotype; Humans; | 2013 |
Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline.
Topics: Animals; Apoptosis; Choline; Diet; DNA Fragmentation; Fatty Liver; Female; Humans; In Situ Nick-End | 2003 |
[Lipotropic substances and fatty liver].
Topics: Choline; Fatty Liver; Lipotropic Agents; Liver Diseases | 1952 |
[Liver fatty degeneration inhibiting factors of foodstuffs].
Topics: Alcohols; Choline; Fatty Liver; Liver Diseases | 1952 |
Development of portal fatty liver in rats on corn diets; response to lipotropic agents.
Topics: Animals; Choline; Diet; Fatty Liver; Lipotropic Agents; Liver Diseases; Methionine; Rats; Vitamin B | 1954 |
Histological differentiation of fatty livers produced by threonine or choline deficiency.
Topics: Choline; Choline Deficiency; Fatty Liver; Liver Diseases; Threonine | 1954 |
[Action of lipotropic factors on hepatic steatosis in experimental hypoxia].
Topics: Choline; Fatty Liver; Humans; Hypoxia; Lipotropic Agents; Liver Diseases; Methionine | 1955 |
[Therapy of the fatty liver with lipotropic substances].
Topics: Choline; Fatty Liver; Humans; Lecithins; Lipotropic Agents; Liver Diseases; Methionine; Phosphatidyl | 1956 |
Effect of choline, heparin and aureomycin on fatty livers of dogs.
Topics: Animals; Chlortetracycline; Choline; Dogs; Fats; Fatty Liver; Heparin; Lipid Metabolism; Liver | 1956 |
[The action of various lipotropic substances on the steatogenic effects of carbon tetrachloride as a function of time].
Topics: Carbon Tetrachloride; Choline; Fatty Liver; Lipotropic Agents; Methionine | 1956 |
[The action of various lipotropic substances on the steatogenic effects of carbon tetrachloride as a function of time].
Topics: Carbon Tetrachloride; Choline; Fatty Liver; Lipotropic Agents; Methionine | 1956 |
[The action of various lipotropic substances on the steatogenic effects of carbon tetrachloride as a function of time].
Topics: Carbon Tetrachloride; Choline; Fatty Liver; Lipotropic Agents; Methionine | 1956 |
[The action of various lipotropic substances on the steatogenic effects of carbon tetrachloride as a function of time].
Topics: Carbon Tetrachloride; Choline; Fatty Liver; Lipotropic Agents; Methionine | 1956 |
Abnormal glucose tolerance in experimental choline-deficient fatty liver.
Topics: Choline; Fatty Liver; Glucose; Glucose Intolerance; Glucose Tolerance Test; Humans | 1957 |
[Simultaneous administration of alcohol and lipotropic drugs in chronic alcoholics; behavior of hepatic steatosis studied by serial punch biopsies].
Topics: Alcoholics; Alcoholism; Biopsy; Choline; Fatty Liver; Humans; Lipotropic Agents; Methionine | 1957 |
[Choline, proteins & fatty overload of liver].
Topics: Choline; Fatty Liver; Humans; Proteins | 1957 |
Influence of starvation on fatty liver.
Topics: Choline; Choline Deficiency; Fatty Liver; Starvation | 1957 |
Ineffectiveness of carnitine as a choline substitute in the prevention of fatty livers of rats maintained on a choline-deficient diet.
Topics: Animals; Carnitine; Choline; Choline Deficiency; Diet; Fatty Liver; Folic Acid; Rats; Vitamin B Comp | 1957 |
[Effect of vitamin B12 & choline on the steatogenic property of a low-protein diet with variable fat & vitamin B content].
Topics: Choline; Diet, Protein-Restricted; Fatty Liver; Protein Deficiency; Vitamin B 12; Vitamin B Complex; | 1957 |
[Effect of choline and inositol on metabolic disorders found in animals with various types of steatosis].
Topics: Animals; Choline; Fatty Liver; Inositol; Metabolic Diseases | 1957 |
Inhibition of chlorpromazine-caused fatty liver with cholinechloride in the white rat.
Topics: Animals; Chlorpromazine; Choline; Fatty Liver; Rats | 1957 |
Metabolism of choline by slices of fatty livers from choline-deficient rats.
Topics: Animals; Choline; Fatty Liver; Rats | 1958 |
Effect of choline on the incorporation of 35S-L-methionine into liver protein of rats with fatty livers.
Topics: Animals; Choline; Fatty Liver; Liver; Methionine; Proteins; Rats | 1958 |
Experimental virus hepatitis in choline-deficient mice with fatty livers.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Hepatitis; Hepatitis A; Mice | 1958 |
[Effect of betaine, administered parenterally, on hepatic steatosis].
Topics: Betaine; Choline; Fatty Liver | 1957 |
Kwashiorkor type of fatty liver in primates.
Topics: Animals; Betaine; Body Weight; Choline; Diet; Dietary Supplements; Fatty Liver; Kwashiorkor; Lipids; | 1958 |
[Importance of lecithin in fat metabolism & experimental fatty liver in rat].
Topics: Animals; Carbon Tetrachloride; Choline; Choline Deficiency; Fatty Liver; Lecithins; Lipid Metabolism | 1958 |
[The prevention of lipophanerosis of the liver by lipotropic substances].
Topics: Biomedical Research; Choline; Fatty Liver; Inositol; Lipotropic Agents; Liver; Methionine | 1958 |
The nature of dietary fat and the pattern of hepatic liposis in choline-deficient mice.
Topics: Animals; Choline; Choline Deficiency; Dietary Fats; Fatty Liver; Lipid Metabolism; Mice | 1959 |
Relationship between choline-deficient fatty liver and chronic alloxan diabetes in rats.
Topics: Animals; Choline; Choline Deficiency; Diabetes Mellitus, Experimental; Fatty Liver; Insulin; Liver D | 1960 |
Fatty cirrhosis in the rat. V. Regression upon return to normal diet.
Topics: Animals; Choline; Diet; Fatty Liver; Fibrosis; Liver Cirrhosis; Liver Cirrhosis, Experimental; Rats | 1963 |
Experimental dietary cirrhosis.
Topics: Animals; Choline; Cystine; Diet; Fatty Liver; Humans; Liver Cirrhosis, Experimental; Methionine; Oro | 1962 |
[On the relation of the amount of choline in the liver and kidney to the fatty liver and hematuria in the choline deficient young rat].
Topics: Animals; Choline; Fatty Liver; Hematuria; Kidney; Rats | 1963 |
INEFFECTIVENESS OF LIPOTROPIC SUBSTANCES IN POSTIRRADIATION FATTY INFILTRATION OF THE LIVER.
Topics: Animals; Choline; Fatty Liver; Lipid Metabolism; Lipotropic Agents; Liver; Methionine; Mice; Radiati | 1963 |
SERUM PROTEINS IN FATTY CIRRHOSIS OF THE RAT.
Topics: Blood Protein Electrophoresis; Choline; Deficiency Diseases; Fatty Liver; gamma-Globulins; Liver Cir | 1964 |
FATTY CIRRHOSIS IN THE RAT. VI. PATTERN OF FAT RE-ACCUMULATION AFTER RE-INSTITUTION OF CHOLINE DEFICIENCY.
Topics: Choline; Choline Deficiency; Fatty Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Dise | 1963 |
ALTERATIONS IN CHOLINE-DEFICIENT CIRRHOSIS. A HISTOCHEMICAL STUDY.
Topics: Choline; Deficiency Diseases; Dihydrolipoamide Dehydrogenase; Electron Transport Complex II; Fatty L | 1964 |
THE FATTY LIVER INDUCTION OF ALPHA-ETHYLTHIOISONICOTINAMIDE (ETHIONIAMIDE, 1314TH).
Topics: Chemical and Drug Induced Liver Injury; Choline; Ethionamide; Fatty Liver; Hepatitis; Nucleosides; P | 1964 |
[STUDIES ON THE EFFECT OF ORALLY ADMINISTERED OXYTETRACYCLINE ON LIVER LIPIDS AND SERUM CHOLESTEROL IN WHITE RATS].
Topics: Cholesterol; Choline; Fatty Liver; Lipid Metabolism; Lipids; Liver; Oxytetracycline; Pharmacology; R | 1963 |
BIOCHEMICAL CHANGES IN FATTY LIVER INDUCED BY CHOLINE OR THREONINE DEFICIENCY. PART I. LEVELS OF INDIVIDUAL PYRIDINE NUCLEOTIDES.
Topics: Choline; Deficiency Diseases; Fasting; Fatty Liver; Fluorescence; NAD; NADP; Nucleotides; Pyridines; | 1964 |
BIOCHEMICAL CHANGES IN FATTY LIVER INDUCED BY CHOLINE OR THREONINE DEFICIENCY. II. VARIOUS HEPATIC ENZYMIC ACTIVITIES DURING THE DEVELOPMENT OF FATTY LIVERS IN RATS.
Topics: Carbohydrate Metabolism; Choline; Citrates; Cytochromes; Deficiency Diseases; Fatty Liver; Glucose-6 | 1964 |
ULTRASTRUCTURAL ALTERATIONS IN EXPERIMENTAL ACUTE HEPATIC FATTY METAMORPHOSIS.
Topics: Animals; Choline; Choline Deficiency; Electrons; Endoplasmic Reticulum; Fatty Liver; Microscopy; Mic | 1964 |
A BLOOD CLOTTING DEFECT IN CHOLINE DEFICIENT RATS.
Topics: Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Tests; Choline; Factor V; Factor V | 1964 |
INFLUENCE OF LACTOSE ON AMOUNT OF LIVER-FAT IN FATTY LIVERS.
Topics: Carbohydrate Metabolism; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cho | 1964 |
FATTY LIVERS INDUCED BY AMINO ACIDS AND INFLUENCE OF OTHER AMINO ACIDS ON THEM.
Topics: Amino Acids; Arginine; Aspartic Acid; Choline; Cystine; Dietary Fats; Fatty Liver; Glutamates; Glyci | 1964 |
CHOLINE DEFICIENCY IN BABOON AND RAT COMPARED.
Topics: Animals; Blood Chemical Analysis; Choline; Choline Deficiency; Deficiency Diseases; Dietary Fats; Di | 1965 |
FATTY LIVERS PRODUCED IN ALBINO RATS BY EXCESS NIACIN IN HIGH FAT DIETS. II. EFFECT OF CHOLINE SUPPLEMENTS.
Topics: Alkaline Phosphatase; Blood Chemical Analysis; Body Weight; Choline; Choline Deficiency; Diet Therap | 1965 |
THE SERUM AND LIVER AMYLASE AND TRANSAMINASE ACTIVITIES IN CHOLINE DEFICIENCY FATTY LIVER AND CIRRHOSIS.
Topics: Alanine Transaminase; Amylases; Choline; Choline Deficiency; Clinical Enzyme Tests; Dietary Proteins | 1965 |
THE EFFECTS OF CHOLINE ON HEPATIC ULTRASTRUCTURAL CHANGES ASSOCIATED WITH THE INTRAVENOUS ADMINISTRATION OF FAT.
Topics: Administration, Intravenous; Choline; Diet; Electrons; Emulsions; Fats; Fatty Liver; Injections, Int | 1965 |
FATTY CIRRHOSIS IN THE RAT. VII. INFLUENCE OF DIFFERENT LEVELS OF DIETARY FAT ON EARLY DEPOSITION OF FAT IN LIVER.
Topics: Choline; Choline Deficiency; Deficiency Diseases; Dietary Fats; Fatty Liver; Liver Cirrhosis; Pathol | 1965 |
EFFECTS OF UNSATURATED FATS ON DIETARY-INDUCED CIRRHOSIS IN THE RAT.
Topics: Biochemical Phenomena; Biochemistry; Cholesterol; Choline; Choline Deficiency; Dietary Fats; Fats, U | 1965 |
FATTY ACID COMPOSITION OF RAT LIVER LIPIDS DURING CHOLINE DEFICIENCY.
Topics: Choline; Choline Deficiency; Dietary Fats; Dietary Proteins; Fatty Acids; Fatty Acids, Essential; Fa | 1965 |
THE EFFECT OF COLD EXPOSURE ON PLASMA AND LIVER CHOLESTEROL LEVELS IN RATS FED VARIOUS DIETS.
Topics: Biochemical Phenomena; Biochemistry; Body Weight; Cholesterol; Choline; Choline Deficiency; Cold Tem | 1964 |
THE LIPOTROPIC ACTION OF COLD. 2. THE INFLUENCE OF COLD AND CHOLINE DEFICIENCY ON SERUM LIPIDS OF RATS AT DIFFERENT INTAKES OF DIETARY METHIONINE.
Topics: Cholesterol; Choline; Choline Deficiency; Cold Temperature; Diet; Fatty Liver; Glycerides; Lipids; L | 1965 |
EFFECTS OF DIETARY LIPID AND DIETHYLSTILBESTROL UPON LIVER FATTY ACIDS OF CHOLINE-DEFICIENT RATS.
Topics: Cholesterol; Choline; Choline Deficiency; Deficiency Diseases; Dietary Fats; Diethylstilbestrol; Fat | 1965 |
THE EFFECTS OF CHOLINE AND RELATED COMPOUNDS ON THE GROWTH AND DEVELOPMENT OF DROSOPHILA MELANOGASTER.
Topics: Amino Acids; Amino Alcohols; Ammonium Compounds; Animals; Betaine; Carnitine; Chemical Phenomena; Ch | 1965 |
Fatty liver of portal type: effects of choline, methionine, and vitamin B12.
Topics: Choline; Fatty Liver; Liver Diseases; Methionine; Vitamin B 12; Vitamin B Complex | 1955 |
DIETARY deficiencies and fatty livers.
Topics: Choline; Diet; Fatty Liver; Humans; Lipid Metabolism; Lipids; Liver Diseases; Protein Deficiency | 1955 |
THE INHIBITION of choline-induced fatty liver by cortisone.
Topics: Choline; Cortisone; Fatty Liver; Humans; Liver Diseases | 1955 |
Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.
Topics: Animals; Choline; Diet; Fatty Liver; Gene Expression; Hepatocytes; Lipid Peroxidation; Liver; Liver | 2003 |
Use of choline supplements in fatty metamorphosis of the liver; a needle biopsy investigation in human beings.
Topics: Biopsy, Needle; Choline; Fatty Liver; Humans; Liver | 1950 |
Liver steatosis in undernourished Chilean children. III. Evaluation of choline treatment with repeated liver biopsies.
Topics: Biopsy; Chile; Choline; Deficiency Diseases; Fatty Liver | 1950 |
[Effect of methionine and choline on the cholestero overload of the liver in experimental steatosis of the liver in the rat].
Topics: Animals; Choline; Fatty Liver; Liver; Methionine; Rats | 1950 |
[Hepatic steatosis due to phosphorus; lipotropic action of choline and of combined choline-inositol].
Topics: Choline; Fatty Liver; Humans; Inositol; Lipotropic Agents; Phosphorus | 1950 |
Lipid content and volume of bile secreted by choline-deficient rats with fatty livers.
Topics: Animals; Bile; Choline; Fatty Liver; Lipids; Rats | 1951 |
[Effect of lipotropic substances upon blood and liver lipoids in experimental fatty liver and in liver cirrhosis in man].
Topics: Choline; Fatty Liver; Lipotropic Agents; Liver; Liver Cirrhosis; Methionine | 1950 |
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Topics: Adenoviridae; Animals; Blotting, Northern; Blotting, Western; Cell Line; Choline; Cytochrome P-450 C | 2005 |
Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model.
Topics: Animals; Choline; Choline Deficiency; Deuterium; Diet; Disease Models, Animal; Fatty Liver; Lipid Me | 2005 |
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Hepatitis; | 2005 |
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2006 |
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Li | 2006 |
Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid.
Topics: Animals; Antioxidants; Benzofurans; Biomarkers; Choline; Choline Deficiency; Chromatography, High Pr | 2006 |
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.
Topics: Acyl-CoA Oxidase; Alanine Transaminase; Animals; Bezafibrate; Carnitine O-Palmitoyltransferase; Chol | 2006 |
Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.
Topics: Animals; Carcinoma, Hepatocellular; Choline; Disease Models, Animal; Disease Progression; Fatty Live | 2006 |
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
Topics: Animals; Chemokine CCL2; Chemokine CCL4; Choline; Choline Deficiency; Cyclooxygenase 2; Diet; Diseas | 2007 |
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
Topics: Animal Feed; Animals; Choline; Collagen Type I; Collagen Type I, alpha 1 Chain; Diabetes Mellitus, T | 2007 |
Choline cannot be replaced by propanolamine in mice.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Liver; Methionine; Mice; Mice, Inbred C57BL; Phos | 2007 |
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Choline; Cytochrome P-450 CYP2E1; Diacylglycerol O | 2007 |
Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animal Feed; Animals; Choline; Connective Tissue Growth Fac | 2007 |
Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Choline Deficiency; Diet; Fatty Acids, Uns | 2007 |
Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis.
Topics: Animals; Choline; Cytochrome P-450 CYP2E1; Fatty Liver; Hepatitis; Liver; Male; Methionine; NF-kappa | 2003 |
Effects of lipid-supplemented total parenteral nutrition on fatty liver disease in a premature neonatal piglet model.
Topics: Animals; Animals, Newborn; Bilirubin; Choline; Dietary Supplements; Disease Models, Animal; Fatty Ac | 2008 |
Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet.
Topics: Adaptation, Physiological; Animal Feed; Animals; Choline; Choline Deficiency; Energy Metabolism; Fat | 2008 |
Effects of rosiglitazone on methionine-choline deficient diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline; Diet; Disease Models, Animal; Fatty Liver | 2007 |
Choline; the cause of lipocaic lipotropic action on fatty rat livers.
Topics: Animals; Choline; Fatty Liver; Lipotropic Agents; Rats | 1949 |
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated | 2008 |
Effect of environmental temperature on fatty livers produced by various hepatotoxic agents in rats.
Topics: Animals; Carbon Tetrachloride; Choline; Diet; Ethanol; Ethionine; Fatty Liver; Female; Lipid Metabol | 1967 |
Effect of 2-N-mono- and 2-N-diethylaminoethanol on normal and choline-deficient rats.
Topics: Amino Alcohols; Animals; Body Weight; Cholesterol; Choline; Choline Deficiency; Emulsions; Fatty Liv | 1967 |
Vitamin B12, choline and related substances in dietary hepatic injury in rats.
Topics: Amino Acids; Animals; Body Weight; Choline; Cystine; Diet; Fatty Liver; Growth; Homocystine; Lipid M | 1967 |
The influence of testosterone on the induction of fatty liver by methionine deficiency.
Topics: Amino Acids; Animals; Castration; Choline; Deficiency Diseases; Diet; Fatty Liver; Female; Glutamate | 1967 |
Lipid transport in experimental dietary hepatic injury in rats.
Topics: Animals; Biological Transport; Cholesterol; Choline; Dietary Proteins; Fats, Unsaturated; Fatty Live | 1967 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi | 1980 |
Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency?
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Female; Humans; Lipotropic Agents; Liver; Pregnan | 1982 |
Interrelationships between biotin, choline and other B-vitamins and the occurrence of fatty liver and kidney syndrome and sudden death syndrome in broiler chickens.
Topics: Animals; Biotin; Chickens; Choline; Death, Sudden; Diet; Fatty Liver; Female; Kidney Diseases; Male; | 1982 |
[Clinical experience report on Hepavis].
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Choline; Dehydrocholic Acid; Drug Co | 1980 |
Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation.
Topics: Adult; Aged; Choline; Choline Deficiency; Fatty Liver; Female; Humans; Infusions, Intravenous; Lipot | 1995 |
Sexually differentiated response to choline in choline deficiency and ethionine intoxication.
Topics: Animals; Blood Proteins; Choline; Choline Deficiency; Ethionine; Fatty Liver; Female; Lipoproteins, | 1995 |
Choline pharmacokinetics during intermittent intravenous choline infusion in human subjects.
Topics: Adult; Analysis of Variance; Choline; Fatty Liver; Female; Humans; Infusions, Intravenous; Male; Mid | 1994 |
Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats.
Topics: Animals; Blotting, Western; Cell Membrane; Choline; Choline Deficiency; Diet; Diglycerides; Fatty Li | 1993 |
Cysteine supplementation and reduction of total parenteral nutrition-induced hepatic lipid accumulation in the weanling rat.
Topics: Acetyl-CoA Carboxylase; Animals; Animals, Suckling; Cells, Cultured; Choline; Cysteine; Fatty Liver; | 1995 |
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver | 1996 |
Hybrid ducks overfed with boiled corn develop an acute hepatic steatosis with decreased choline and polyunsaturated fatty acid level in phospholipids.
Topics: Animal Feed; Animals; Choline; Ducks; Fatty Acids, Unsaturated; Fatty Liver; Hot Temperature; Lipids | 1996 |
Sinusoidal flow block after warm ischemia in rats with diet-induced fatty liver.
Topics: Animals; Antibodies, Monoclonal; Antithrombin III; Choline; Diet; Fatty Liver; Fibrinogen; Hot Tempe | 1997 |
Hepatic protein kinase C is not activated despite high intracellular 1,2-sn-diacylglycerol in obese Zucker rats.
Topics: Animals; Cell Membrane; Choline; Diglycerides; Enzyme Activation; Fatty Liver; Liver; Obesity; Prote | 1997 |
The effect of a combined dietary treatment with cholesterol and cholic acid on the lipid metabolism of geese at low or high choline concentrations.
Topics: Animals; Body Weight; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Cholest | 1999 |
Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis.
Topics: Celiac Disease; Choline; Fatty Acids, Nonesterified; Fatty Liver; Female; Humans; Liver; Male; Middl | 2001 |
Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
Topics: Animal Feed; Animals; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cholesterol; Choline | 2002 |
Effect of inositol, lecithin, vitamins (B12 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens.
Topics: Animal Feed; Animals; Caseins; Chickens; Choline; Eggs; Fatty Liver; Female; Hemorrhage; Inositol; I | 1975 |
[Clinical and experimental studies on changes in lysosomal enzyme activity in fatty livers (author's transl)].
Topics: Acid Phosphatase; Adolescent; Adult; Animals; Choline; Ethionine; Fatty Liver; Fatty Liver, Alcoholi | 1978 |
The activity of silybin on phospholipid metabolism of normal and fatty liver in vivo.
Topics: Animals; Choline; Ethanol; Ethanolamines; Ethionine; Fatty Liver; Female; Flavonoids; Liver; Phospho | 1977 |
Chronic toxicity of methotrexate in rats: partial to complete projection of the liver by choline: Brief communication.
Topics: Animals; Bone Marrow; Choline; Choline Deficiency; Fatty Liver; Liver; Male; Methotrexate; Rats | 1977 |
Factors affecting liver lipid content in pyridoxing-deficient rats. I. Dietary protein levels.
Topics: Alanine Transaminase; Animals; Caseins; Choline; Dietary Proteins; Fatty Liver; Kidney; Lipid Metabo | 1976 |
The effects of choline and inositol on hepatic lipid metabolism and the incidence of the fatty liver and kidney syndrome in broilers.
Topics: Animal Feed; Animals; ATP Citrate (pro-S)-Lyase; Chickens; Choline; Dietary Proteins; Fatty Liver; I | 1975 |
[Current biochemical, clinical and therapeutic views on the subject of liver steatosis].
Topics: Adenosine Triphosphate; Choline; Fatty Liver; Humans; Triglycerides; Vitamin B Complex; Vitamin E | 1975 |
Dietary management of idiopathic feline hepatic lipidosis with a liquid diet supplemented with citrulline and choline.
Topics: Animals; Cat Diseases; Cats; Choline; Citrulline; Diet; Enteral Nutrition; Fatty Liver; Intubation, | 1991 |
Lipotropic activity of inositol and chlortetracycline alone and in various combinations of choline, vitamin B 12 and folic acid. Activity of three liver extracts with assays for these substances.
Topics: Animals; Body Weight; Cattle; Chlortetracycline; Choline; Dietary Fats; Drug Combinations; Fatty Liv | 1971 |
Production of a fatty liver by ethanol in rhesus monkeys.
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Alcoholic Intoxication; Alkaline Phosphatase; Animals | 1972 |
Lipotropic effect of dextrin versus sucrose in choline-deficient rats.
Topics: Animals; Bacteria; Cecum; Choline; Choline Deficiency; Diet; Dietary Carbohydrates; Fatty Liver; Fec | 1970 |
[Effect of cholineorotate on experimental fatty liver in the rat].
Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Choline; Fatty Liver; Li | 1970 |
The effect of acute ethanol ingestion on in vitro metabolism of choline and ethanol derivatives in rat liver.
Topics: Animals; Choline; Diet; Ethanol; Ethanolamines; Fatty Liver; Female; Lipids; Liver; Membranes; Methy | 1974 |
Failure of vitamin supplementation to alter the fatty liver syndrome caused by aflatoxin.
Topics: Aflatoxins; Animals; Aspergillus flavus; Chickens; Choline; Fatty Liver; Female; Inositol; Lipids; L | 1972 |
Effect of diet on fatty liver-hemorrhagic syndrome incidence in laying chickens.
Topics: Animals; Body Weight; Chickens; Choline; Cobalt; Diet; Fatty Liver; Female; Hemorrhage; Inositol; Li | 1972 |
Involvement of diet in fatty liver and kidney syndrome in broiler chickens.
Topics: Animal Feed; Animals; Chickens; Choline; Diet; Edible Grain; Fatty Liver; Kidney; Kidney Diseases; L | 1973 |
Phenobarbital-induced fatty livers in the rat.
Topics: Animals; Cholesterol; Choline; Choline Deficiency; Dietary Fats; Dietary Proteins; Fatty Liver; Inje | 1973 |
Observations on the relationship of hepatic choline uptake to ethanolic fatty liver in the rat.
Topics: Animals; Carbon Isotopes; Chlorine; Choline; Ethanol; Fatty Liver; Glucose; Lipids; Lipoproteins; Li | 1973 |
The effects of feeding an elemental chemical diet to mature rats: toxicologic and pathologic studies.
Topics: Animals; Body Weight; Choline; Deficiency Diseases; Diet; Drinking Behavior; Fatty Liver; Feces; Fee | 1973 |
[Clinical treatment of acute and chronic liver diseases].
Topics: Acute Disease; Choline; Chronic Disease; Fatty Liver; Hepatitis; Humans; Liver Diseases; Male; Methi | 1972 |
A quantitative morphological analysis of ethanol effect upon rat liver.
Topics: Animals; Choline; Endoplasmic Reticulum; Ethanol; Fatty Liver; Glycogen; Golgi Apparatus; Lipids; Li | 1972 |
[Dietetic therapy of liver diseases].
Topics: Choline; Chronic Disease; Diet Therapy; Dietary Proteins; Fatty Acids; Fatty Liver; Hepatic Encephal | 1972 |
Responses of fatty livers of mice of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Choline; Choline Deficiency; Dietary | 1969 |
Mode of action of choline. IV. Activity of the enzymes related to fatty acid synthesis and the levels of metabolic intermediates in choline-deficient rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Alcohol Oxidoreductases; Animals; Carbon Isotopes; Chol | 1969 |
Effect of alcohol on the liver of rats. II. Factors contributing to elevations of plasma transaminase activities and hepatic cell necrosis following a single administration of alcohol in rats.
Topics: Alcohols; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury | 1969 |
[Fibrosis and cirrhosis in the rat liver after the replacement of a proteinand choline-deficient diet with a complete one].
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Proteins; Fatty Liver; Liver Cirrhosis; Methods; | 1969 |
Early changes in livers of rats fed choline-deficient diets at four levels of protein.
Topics: Alkaline Phosphatase; Animals; Blood Proteins; Body Weight; Choline; Cystine; Diet; Dietary Proteins | 1969 |
Early effects of carbon tetrachloride on the synthesis of phospholipids in the rat liver and their possible pathogenetic role in fatty liver induction.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Carbon Tetrachloride; Choline; Chromatography, Thin Layer; | 1969 |
Reticuloendothelial activity in choline-deficient or carbon tetrachloride-treated rats.
Topics: Animals; Biological Transport; Carbon; Carbon Tetrachloride Poisoning; Choline; Choline Deficiency; | 1970 |
Studies on myoinositol. V. Effect of myoinositol on the prevention of fatty liver induced by orotic acid.
Topics: Animals; Choline; Fatty Liver; Injections, Subcutaneous; Inositol; Lipid Metabolism; Liver; Male; Mu | 1970 |
Retardation of microsomal protein synthesis in rat liver due to induction of Handler's experimental fatty liver.
Topics: Animals; Choline; Fatty Liver; Injections, Subcutaneous; Inositol; Leucine; Male; Microsomes, Liver; | 1970 |
Mode of action of choline. V. Sequential changes in hepatic and serum lipids of choline-deficient rats.
Topics: Animals; Choline; Deficiency Diseases; Fatty Liver; Liver; Male; Microsomes, Liver; Phosphatidylchol | 1970 |
Effect of phenobarbital on the development of fatty livers in choline-deficient rats.
Topics: Animals; Choline; Deficiency Diseases; Fatty Liver; Humans; Liver; Male; Phenobarbital; Phospholipid | 1970 |
Further studies on the partial lipotropic effect of dextrin in choline-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Dietary Carbohydrates; Fatty Liver; Fructose; Glucose; Lipid M | 1971 |
Methionine-responsive liver damage in young pigs fed a diet low in protien and vitamin E.
Topics: Animals; Aspartate Aminotransferases; Blood Proteins; Body Weight; Choline; Diet; Fatty Liver; Femal | 1968 |
Effect of pancreatin on the absorption of Fe59 in rats with fatty liver.
Topics: Animals; Bromelains; Choline; Fatty Liver; Female; Iron; Iron Isotopes; Pancreatic Extracts; Pancrea | 1968 |
Studies on myoinositol. IV. Effect of myoinositol on the cholesterol metabolism of rats suffering from experimental fatty liver.
Topics: Acetates; Adipose Tissue; Animals; Carbon Isotopes; Cholesterol; Choline; Fatty Liver; Inositol; Lip | 1968 |
Choline-deficiency fatty liver: impaired release of hepatic triglycerides.
Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Diet; Fatty Liver; Hyperlipidemias; Intestina | 1968 |
[On methylation processes in metabolism].
Topics: Biochemical Phenomena; Biochemistry; Choline; Dietary Fats; Epinephrine; Fatty Liver; Humans; Mescal | 1969 |
Studies on phospholipid metabolism in choline deficient fatty liver.
Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Chromatography; Fatty Acids; Fatty Liver; Fem | 1969 |
Metabolism of phosphorylcholine and lecithin in normal and choline-deficient rats.
Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Fatty Liver; Lipid Metabolism; Liver; Male; M | 1969 |
Liver phospholipids of rats deprived of dietary choline.
Topics: Animals; Arachidonic Acids; Body Weight; Choline; Chromatography, Gas; Fatty Acids; Fatty Liver; Foo | 1969 |
[Considerations on the therapy of hepatic steatosis].
Topics: Adult; Aged; Alcoholism; Choline; Colitis, Ulcerative; Diabetes Complications; Fatty Liver; Gout; He | 1969 |
Alterations in phospholipid metabolism induced by ethanol administration.
Topics: Alkylation; Animals; Choline; Chromatography, Thin Layer; Ethanol; Fatty Liver; Formates; In Vitro T | 1965 |
[Urinary elimination of 17-ketosteroids in experimental steatosis due to cholesterin and in steatosis due to cholesterin treated with methylating substances, testosterone and vitamin E (experimental research)].
Topics: 17-Ketosteroids; Animals; Betaine; Cholesterol; Choline; Fatty Liver; Quaternary Ammonium Compounds; | 1964 |
Studies on the rapid accumulation of triglyceride in the liver in choline deficiency.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Fatty Liver; Glycerides; Lipoproteins; Li | 1965 |
Choline metabolism in normal and choline-deficient rats of different ages.
Topics: Aging; Animals; Body Weight; Choline; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Me | 1965 |
[Effect of choline chloride and (-)-carnitine of the experimental fatty liver in the rat].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carnitine; Choline; Fatty Liver; Liver; Rats | 1965 |
Livers of choline-deficient pregnant and fetal rats.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Fatty Liver; Female; Fetus; Liver; Pregna | 1965 |
Fatty cirrhosis in the rat. 8. Effect of dietary fat.
Topics: Animals; Choline; Choline Deficiency; Cottonseed Oil; Dietary Fats; Fatty Acids, Essential; Fatty Li | 1965 |
Diurnal changes in liver and plasma lipids of choline-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Circadian Rhythm; Deficiency Diseases; Fatty Liver; In Vitro T | 1966 |
Environmental temperature and choline requirement in rats. I. Choline deficiency in rats at various temperatures.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Diet; Fatty Liver; In Vitro Techniques; L | 1966 |
Environmental temperature and choline requirements in rats. II. Choline and methionine requirements for lipotropic activity.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Fatty Liver; Lipid Metabolism; Liver; Met | 1966 |
Choline-deficiency fatty liver: relation of plasma phospholipids to liver triglycerides.
Topics: Animals; Chemistry Techniques, Analytical; Choline; Choline Deficiency; Chromatography, Thin Layer; | 1966 |
Cirrhosis-enhancing effect of corn oil. Protection by choline.
Topics: Animals; Cholesterol; Choline; Diet; Dietary Fats; Fats, Unsaturated; Fatty Liver; Glycerides; Growt | 1966 |
Fatty cirrhosis in the rat.
Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats; | 1966 |
Fatty cirrhosis in the rat. X. Effect of sex.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; DNA; Fatty Liver; Female; Liver Cirrhosis | 1966 |
The effects of choline deficiency and choline re-feeding upon the metabolism of plasma and liver lipids.
Topics: Amino Alcohols; Animals; Choline; Deficiency Diseases; Fatty Liver; Lipid Metabolism; Liver; Palmiti | 1966 |
Study of agents for the prevention of the fatty liver produced by prolonged alcohol intake.
Topics: Alcohol Deterrents; Alcoholism; Animals; Antioxidants; Choline; Diet; Fatty Liver; Glycerides; Human | 1966 |