choline has been researched along with Liver Neoplasms in 149 studies
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this pilot study was to evaluate the use of PET/CT with (18)F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH)." | 9.15 | Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT. ( Bennink, RJ; Beuers, UH; Bieze, M; van den Esschert, JW; van Gulik, TM, 2011) |
| "This prospective study aimed to compare the diagnostic performance of (18)F-fluorocholine and (18)F-FDG for detecting and staging hepatocellular carcinoma (HCC) in patients with chronic liver disease and suspected liver nodules." | 9.14 | Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease. ( Ancel, D; Balogova, S; Fartoux, L; Grange, JD; Gutman, F; Huchet, V; Kerrou, K; Nataf, V; Rosmorduc, O; Talbot, JN, 2010) |
| "In hepatocellular carcinoma (HCC) setting, 18 F-FDG and 18 F-choline PET/CT radiotracers are classically considered surrogates of the degree of differentiation, a strong predictor of disease recurrence after curative treatment." | 8.31 | Is 18 F-FDG/ 18 F-Choline Dual-Tracer PET Behavior a Surrogate of Tumor Differentiation in Hepatocellular Carcinoma : A Tertiary Center Dedicated Study. ( Besson, FL; Durand, E; Golse, N; Pascale, A; Sebagh, M; Sivapathasundaram, A, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 8.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "The dietary intakes of choline and betaine have been related to the mortality of some neoplasms, but their effects on hepatocellular carcinoma (HCC) mortality are still unknown." | 7.96 | Dietary choline, rather than betaine intake, is associated with hepatocellular carcinoma mortality. ( Fang, AP; Liu, ZY; Luo, Y; Yishake, D; Zhang, DM; Zhu, HL, 2020) |
| "A 57-year-old man was referred to our institution for F-fluorocholine PET/CT to characterize a pulmonary nodule in a context of hepatocellular carcinoma." | 7.91 | Arterial Phase 18F-Fluorocholine PET/CT in Hepatocellular Carcinoma. ( Aziz, AL; Collet, G; Lahousse, H; Legendre, A; Petyt, G, 2019) |
| "The aim of this study was to retrospectively analyze the prognostic value of combined Tc-macroaggregated albumin (MAA) SPECT/CT and [F]-fluoroethylcholine (FEC) PET/CT before radioembolization for survival of patients with intermediate-stage hepatocellular carcinoma." | 7.88 | Combined [18F]-Fluoroethylcholine PET/CT and 99mTc-Macroaggregated Albumin SPECT/CT Predict Survival in Patients With Intermediate-Stage Hepatocellular Carcinoma. ( Albert, NL; Bartenstein, P; Hacker, M; Hartenbach, M; Hartenbach, S; Haug, AR; Paprottka, PM; Pilz, M; Tiling, R; Weber, S; Zacherl, MJ, 2018) |
| "Using a combination of tracers 18F-fluorocholine and 18F-fluorodeoxyglucose when performing positron emission tomography/computed tomography (PET/CT), often called a PET scan, helps to identify new tumor lesions in patients with hepatocellular carcinoma." | 7.88 | Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma. ( Allaire, M; Amaddeo, G; Azoulay, D; Baranes, L; Calderaro, J; Chalaye, J; Costentin, CE; Duvoux, C; Ganne-Carrié, N; Itti, E; Luciani, A; Mallat, A; Nahon, P; Nault, JC; Seror, O; Soussan, M, 2018) |
| "The aim of this study was to report the impact of C-choline PET/CT on the management of patients with hepatocellular carcinoma (HCC) and incorporate into a refined algorithm combining diagnostic imaging and multidisciplinary team (MDT) discussion." | 7.85 | Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion. ( Balzarini, L; Chiti, A; Donadon, M; Felisaz, P; Lanza, E; Lopci, E; Mimmo, A; Torzilli, G, 2017) |
| "C57BL/6-GFP transgenic mice were fed with a choline-deficient diet in order to establish a fatty liver model." | 7.85 | Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. ( Aoki, H; Hasegawa, K; Hoffman, RM; Kunisada, T; Matsumoto, T; Moriwaki, H; Nakamura, M; Saji, S; Shimizu, M; Suetsugu, A, 2017) |
| "In this prospective study, our goal was to emphasize the diagnostic value of combining (11)C-choline and (18)F-FDG PET/CT for hepatocellular carcinoma (HCC) in patients with chronic liver disease." | 7.83 | Diagnostic value of combining ¹¹C-choline and ¹⁸F-FDG PET/CT in hepatocellular carcinoma. ( Agostini, H; Castilla-Lièvre, MA; Désarnaud, S; Franco, D; Gervais, P; Helal, BO; Kuhnast, B; Marthey, L, 2016) |
| "The aim of this study was to compare C11 choline and F18 FDG PET/CT, gadoxeticenhanced 3T MRI and contrastenhanced CT for diagnosis of hepatocellular carcinoma (HCC)." | 7.83 | Diagnosis of Hepatocellular Carcinoma Using C11 Choline PET/CT: Comparison with F18 FDG, ContrastEnhanced MRI and MDCT. ( Chotipanich, C; Kunawudhi, A; Promteangtrong, C; Sricharunrat, T; Tungsuppawattanakit, P; Wongsa, P, 2016) |
| "The aim of this study was to evaluate (18)F-fluoroethylcholine PET/CT as a metabolic imaging technique for the assessment of treatment response to (90)Y radioembolization in patients with locally advanced hepatocellular carcinoma (HCC)." | 7.81 | Evaluating Treatment Response of Radioembolization in Intermediate-Stage Hepatocellular Carcinoma Patients Using 18F-Fluoroethylcholine PET/CT. ( Albert, NL; Bartenstein, P; Hacker, M; Hartenbach, M; Hartenbach, S; Haug, AR; Hirtl, A; Paprottka, PM; Tiling, R; Weber, S; Zacherl, MJ, 2015) |
| "In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting." | 7.81 | Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma. ( Ceriani, R; Chiti, A; Comito, T; de Neto, LJ; Donadon, M; Lanza, E; Lopci, E; Palmisano, A; Pedicini, V; Personeni, N; Poretti, D; Rimassa, L; Sabongi, JG; Scorsetti, M; Torzilli, G, 2015) |
| "Choline-based radiotracers have been studied for PET imaging of hepatocellular carcinoma (HCC)." | 7.77 | PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline. ( Corn, DJ; Kolthammer, JA; Lee, Z; Tenley, N; Tian, H; Wang, Y; Wu, C, 2011) |
| "PET with [methyl-(11)C]-choline (11C-choline) can be useful for detecting well-differentiated hepatocellular carcinoma (HCC) that is not 18F-FDG-avid." | 7.77 | Imaging lipid synthesis in hepatocellular carcinoma with [methyl-11c]choline: correlation with in vivo metabolic studies. ( Corn, DJ; Kolthammer, JA; Kuang, Y; Lee, Z; Salem, N; Tian, H; Wang, F; Wang, Y; Wu, C, 2011) |
| " We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet." | 7.74 | Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. ( Honoki, K; Mori, C; Nishikawa, T; Onishi, M; Sokuza, Y; Tsujiuchi, T; Uwataki, K, 2007) |
| "The purpose of this study was to retrospectively investigate the feasibility of 11C-choline PET, compared with 18F-FDG PET, for the detection of hepatocellular carcinoma (HCC)." | 7.74 | Detection of hepatocellular carcinoma using 11C-choline PET: comparison with 18F-FDG PET. ( Deguchi, A; Kaji, M; Kameyama, R; Kashiwagi, H; Nishiyama, Y; Ohkawa, M; Okano, K; Yamamoto, Y, 2008) |
| "To prospectively investigate the apparent diffusion coefficient (ADC) and choline levels measured at hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopy, to monitor therapeutic responses of hepatocellular carcinoma (HCC) to transcatheter arterial chemoembolization (TACE)." | 7.73 | Early response of hepatocellular carcinoma to transcatheter arterial chemoembolization: choline levels and MR diffusion constants--initial experience. ( Chen, CY; Hsu, JS; Jao, JC; Jaw, TS; Kuo, YT; Li, CW; Liu, GC; Wu, DK, 2006) |
| "Diagnosis of hepatocellular carcinoma (HCC) primarily involves imaging." | 6.79 | Diagnostic accuracy of (18) F-methylcholine positron emission tomography/computed tomography for intra- and extrahepatic hepatocellular carcinoma. ( Bennink, RJ; Beuers, U; Bieze, M; Klümpen, HJ; Phoa, SS; van Gulik, TM; Verheij, J, 2014) |
| "Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies." | 6.78 | The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy. ( Bennink, RJ; Beuers, U; Bieze, M; El-Massoudi, Y; Phoa, SS; van Gulik, TM; Verheij, J, 2013) |
| "A 76-year-old man, who experienced prostate cancer biochemical relapse after 12 years from radical prostatectomy, underwent abdominal CT scan for restaging purposes, negative for metastases, and then C-choline PET/CT." | 5.56 | Incidental Finding on 11C-Choline-PET/CT of Hepatocellular Carcinoma Recurrence in a Prostate Cancer Patient With Negative Abdominal CT Scan. ( Boero, M; Guglielmo, P; Pisu, N; Pung, BLJ; Sanna, S, 2020) |
| "Pioglitazone is an effective agent for chemoprevention in rodents and could be repurposed as a multi-targeted drug for delaying liver fibrosis and hepatocarcinogenesis." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Diagnosis of recurrent hepatocellular carcinoma (HCC) is sometimes challenging, especially when extrahepatic disease is present." | 5.43 | Recurrent Extrahepatic Hepatocellular Carcinoma Detected by 18F-Choline PET/CT. ( Geier, A; Götze, O; Lapa, C; Schmid, JS; Weiss, J, 2016) |
| "Hepatoblastoma is a rare carcinoma mostly seen in children." | 5.39 | Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT. ( Bennink, RJ; Bieze, M; van Gulik, TM, 2013) |
| "The aim of this pilot study was to evaluate the use of PET/CT with (18)F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH)." | 5.15 | Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT. ( Bennink, RJ; Beuers, UH; Bieze, M; van den Esschert, JW; van Gulik, TM, 2011) |
| "This prospective study aimed to compare the diagnostic performance of (18)F-fluorocholine and (18)F-FDG for detecting and staging hepatocellular carcinoma (HCC) in patients with chronic liver disease and suspected liver nodules." | 5.14 | Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease. ( Ancel, D; Balogova, S; Fartoux, L; Grange, JD; Gutman, F; Huchet, V; Kerrou, K; Nataf, V; Rosmorduc, O; Talbot, JN, 2010) |
| " The fluorine-18 ((18)F)-labeled choline derivative fluorocholine (FCH) in particular has demonstrated potential utility for imaging of a variety of neoplasms, including those of the breast, prostate, liver, and brain." | 4.84 | Cancer imaging with fluorine-18-labeled choline derivatives. ( Coel, MN; DeGrado, TR; Gutman, F; Kwee, SA; Talbot, JN, 2007) |
| " Previously, we reported a dietary mouse NASH model with a choline-deficient, methionine-lowered, L-amino-acid-defined, high-fat diet containing shortening without trans fatty acids (CDAA-HF-T[-]), which rapidly induces fibrosis and proliferative lesions in the liver." | 4.31 | Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes. ( Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M, 2023) |
| "In hepatocellular carcinoma (HCC) setting, 18 F-FDG and 18 F-choline PET/CT radiotracers are classically considered surrogates of the degree of differentiation, a strong predictor of disease recurrence after curative treatment." | 4.31 | Is 18 F-FDG/ 18 F-Choline Dual-Tracer PET Behavior a Surrogate of Tumor Differentiation in Hepatocellular Carcinoma : A Tertiary Center Dedicated Study. ( Besson, FL; Durand, E; Golse, N; Pascale, A; Sebagh, M; Sivapathasundaram, A, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 4.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "To compare the performance of the quantitative analysis of the hepatobiliary phase (HBP) tumor enhancement in gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI and of dual-tracer 18F-FDG and 18F-fluorocholine (FCH) PET/CT for the prediction of tumor aggressiveness and recurrence-free survival (RFS) in resectable hepatocellular carcinoma (HCC)." | 3.96 | Hepatobiliary MR contrast agent uptake as a predictive biomarker of aggressive features on pathology and reduced recurrence-free survival in resectable hepatocellular carcinoma: comparison with dual-tracer 18F-FDG and 18F-FCH PET/CT. ( Amaddeo, G; Calderaro, J; Chalaye, J; Galletto Pregliasco, A; Itti, E; Kharrat, R; Kobeiter, H; Laurent, A; Legou, F; Luciani, A; Mulé, S; Regnault, H; Tacher, V; Tenenhaus, A, 2020) |
| "The dietary intakes of choline and betaine have been related to the mortality of some neoplasms, but their effects on hepatocellular carcinoma (HCC) mortality are still unknown." | 3.96 | Dietary choline, rather than betaine intake, is associated with hepatocellular carcinoma mortality. ( Fang, AP; Liu, ZY; Luo, Y; Yishake, D; Zhang, DM; Zhu, HL, 2020) |
| "A 57-year-old man was referred to our institution for F-fluorocholine PET/CT to characterize a pulmonary nodule in a context of hepatocellular carcinoma." | 3.91 | Arterial Phase 18F-Fluorocholine PET/CT in Hepatocellular Carcinoma. ( Aziz, AL; Collet, G; Lahousse, H; Legendre, A; Petyt, G, 2019) |
| "Using a combination of tracers 18F-fluorocholine and 18F-fluorodeoxyglucose when performing positron emission tomography/computed tomography (PET/CT), often called a PET scan, helps to identify new tumor lesions in patients with hepatocellular carcinoma." | 3.88 | Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma. ( Allaire, M; Amaddeo, G; Azoulay, D; Baranes, L; Calderaro, J; Chalaye, J; Costentin, CE; Duvoux, C; Ganne-Carrié, N; Itti, E; Luciani, A; Mallat, A; Nahon, P; Nault, JC; Seror, O; Soussan, M, 2018) |
| "The aim of this study was to retrospectively analyze the prognostic value of combined Tc-macroaggregated albumin (MAA) SPECT/CT and [F]-fluoroethylcholine (FEC) PET/CT before radioembolization for survival of patients with intermediate-stage hepatocellular carcinoma." | 3.88 | Combined [18F]-Fluoroethylcholine PET/CT and 99mTc-Macroaggregated Albumin SPECT/CT Predict Survival in Patients With Intermediate-Stage Hepatocellular Carcinoma. ( Albert, NL; Bartenstein, P; Hacker, M; Hartenbach, M; Hartenbach, S; Haug, AR; Paprottka, PM; Pilz, M; Tiling, R; Weber, S; Zacherl, MJ, 2018) |
| "C57BL/6-GFP transgenic mice were fed with a choline-deficient diet in order to establish a fatty liver model." | 3.85 | Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. ( Aoki, H; Hasegawa, K; Hoffman, RM; Kunisada, T; Matsumoto, T; Moriwaki, H; Nakamura, M; Saji, S; Shimizu, M; Suetsugu, A, 2017) |
| "The aim of this study was to report the impact of C-choline PET/CT on the management of patients with hepatocellular carcinoma (HCC) and incorporate into a refined algorithm combining diagnostic imaging and multidisciplinary team (MDT) discussion." | 3.85 | Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion. ( Balzarini, L; Chiti, A; Donadon, M; Felisaz, P; Lanza, E; Lopci, E; Mimmo, A; Torzilli, G, 2017) |
| "In this prospective study, our goal was to emphasize the diagnostic value of combining (11)C-choline and (18)F-FDG PET/CT for hepatocellular carcinoma (HCC) in patients with chronic liver disease." | 3.83 | Diagnostic value of combining ¹¹C-choline and ¹⁸F-FDG PET/CT in hepatocellular carcinoma. ( Agostini, H; Castilla-Lièvre, MA; Désarnaud, S; Franco, D; Gervais, P; Helal, BO; Kuhnast, B; Marthey, L, 2016) |
| "The aim of this study was to compare C11 choline and F18 FDG PET/CT, gadoxeticenhanced 3T MRI and contrastenhanced CT for diagnosis of hepatocellular carcinoma (HCC)." | 3.83 | Diagnosis of Hepatocellular Carcinoma Using C11 Choline PET/CT: Comparison with F18 FDG, ContrastEnhanced MRI and MDCT. ( Chotipanich, C; Kunawudhi, A; Promteangtrong, C; Sricharunrat, T; Tungsuppawattanakit, P; Wongsa, P, 2016) |
| "In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting." | 3.81 | Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma. ( Ceriani, R; Chiti, A; Comito, T; de Neto, LJ; Donadon, M; Lanza, E; Lopci, E; Palmisano, A; Pedicini, V; Personeni, N; Poretti, D; Rimassa, L; Sabongi, JG; Scorsetti, M; Torzilli, G, 2015) |
| "The aim of this study was to evaluate (18)F-fluoroethylcholine PET/CT as a metabolic imaging technique for the assessment of treatment response to (90)Y radioembolization in patients with locally advanced hepatocellular carcinoma (HCC)." | 3.81 | Evaluating Treatment Response of Radioembolization in Intermediate-Stage Hepatocellular Carcinoma Patients Using 18F-Fluoroethylcholine PET/CT. ( Albert, NL; Bartenstein, P; Hacker, M; Hartenbach, M; Hartenbach, S; Haug, AR; Hirtl, A; Paprottka, PM; Tiling, R; Weber, S; Zacherl, MJ, 2015) |
| "Rats fed diets deficient in choline develop hepatocellular carcinoma." | 3.79 | Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma. ( Arning, E; Bottiglieri, T; Butler, LM; Gao, YT; Govindarajan, S; Wang, R; Yuan, JM, 2013) |
| "PET with [methyl-(11)C]-choline (11C-choline) can be useful for detecting well-differentiated hepatocellular carcinoma (HCC) that is not 18F-FDG-avid." | 3.77 | Imaging lipid synthesis in hepatocellular carcinoma with [methyl-11c]choline: correlation with in vivo metabolic studies. ( Corn, DJ; Kolthammer, JA; Kuang, Y; Lee, Z; Salem, N; Tian, H; Wang, F; Wang, Y; Wu, C, 2011) |
| "Choline-based radiotracers have been studied for PET imaging of hepatocellular carcinoma (HCC)." | 3.77 | PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline. ( Corn, DJ; Kolthammer, JA; Lee, Z; Tenley, N; Tian, H; Wang, Y; Wu, C, 2011) |
| " We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet." | 3.74 | Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. ( Honoki, K; Mori, C; Nishikawa, T; Onishi, M; Sokuza, Y; Tsujiuchi, T; Uwataki, K, 2007) |
| "The purpose of this study was to retrospectively investigate the feasibility of 11C-choline PET, compared with 18F-FDG PET, for the detection of hepatocellular carcinoma (HCC)." | 3.74 | Detection of hepatocellular carcinoma using 11C-choline PET: comparison with 18F-FDG PET. ( Deguchi, A; Kaji, M; Kameyama, R; Kashiwagi, H; Nishiyama, Y; Ohkawa, M; Okano, K; Yamamoto, Y, 2008) |
| "Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls." | 3.73 | In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006) |
| "To prospectively investigate the apparent diffusion coefficient (ADC) and choline levels measured at hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopy, to monitor therapeutic responses of hepatocellular carcinoma (HCC) to transcatheter arterial chemoembolization (TACE)." | 3.73 | Early response of hepatocellular carcinoma to transcatheter arterial chemoembolization: choline levels and MR diffusion constants--initial experience. ( Chen, CY; Hsu, JS; Jao, JC; Jaw, TS; Kuo, YT; Li, CW; Liu, GC; Wu, DK, 2006) |
| "To elucidate involvement of the transforming growth factor-beta (TGF-beta) signaling pathway in endogenous and exogenous liver carcinogenesis, we investigated mutations of TGF-beta receptor type II (TGF-betaRII), Smad2 and Smad4 genes, and expression of TGF-betaRII in hepatocellular carcinomas (HCCs) induced by a choline-deficient L-amino acid-defined (CDAA) diet and by N-nitrosodiethylamine (DEN)." | 3.71 | Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats. ( Konishi, Y; Murata, N; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M, 2001) |
| "Expression of cyclooxygenase (COX)-2 protein during rat hepatocarcinogenesis associated with fatty change, fibrosis, cirrhosis and oxidative DNA damage, caused by a choline-deficient, L-amino acid-defined (CDAA) diet were investigated in F344 male rats, along with the chemopreventive efficacy of the specific COX-2 inhibitor, nimesulide (NIM)." | 3.71 | Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide. ( Denda, A; Kishida, H; Kitayama, W; Konishi, Y; Kusuoka, O; Murata, A; Nakae, D; Sasaki, Y; Takagi, H; Tsujiuchi, T; Tsutsumi, M, 2002) |
| "The effects of the chronic administration of methyl-deficient, amino acid-defined diets on liver tumor formation were examined in male weanling C3H/HeN mice previously treated with a single ip injection of 0 or 150 mg diethylnitrosamine/kg body weight [(DENA) CAS: 55-18-5]." | 3.67 | Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets. ( Creasia, D; Hoover, KL; Mikol, YB; Poirier, LA; Shivapurkar, N; Wilson, MJ, 1986) |
| "Choline deficiency is associated with triacylglycerol accumulation in the liver, and is the only nutritional state known to trigger hepatic cancer spontaneously." | 3.67 | 1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity? ( Blusztajn, JK; Zeisel, SH, 1989) |
| "Diagnosis of hepatocellular carcinoma (HCC) primarily involves imaging." | 2.79 | Diagnostic accuracy of (18) F-methylcholine positron emission tomography/computed tomography for intra- and extrahepatic hepatocellular carcinoma. ( Bennink, RJ; Beuers, U; Bieze, M; Klümpen, HJ; Phoa, SS; van Gulik, TM; Verheij, J, 2014) |
| "Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies." | 2.78 | The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy. ( Bennink, RJ; Beuers, U; Bieze, M; El-Massoudi, Y; Phoa, SS; van Gulik, TM; Verheij, J, 2013) |
| "Primary liver cancer is the fifth most common malignancy in men and the eighth in women worldwide." | 2.47 | In vivo magnetic resonance spectroscopy of liver tumors and metastases. ( Heerschap, A; Heijmen, L; ter Voert, EG; van Laarhoven, HW, 2011) |
| " Later work indicated that in rats and mice, diets deficient in labile methyl groups (choline, methionine, betaine, folate) produced fatty liver and that long-term administration of diets deficient in choline and methionine also caused hepatocellular carcinoma." | 2.44 | Methionine metabolism and liver disease. ( Lu, SC; Martínez-Chantar, ML; Mato, JM, 2008) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC." | 1.91 | Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis. ( Deepa, SS; Freeman, WM; Georgescu, C; Haritha, NH; Janknecht, R; Luo, W; Miller, BF; Mohammed, S; Nicklas, EH; Oh, S; Ohene-Marfo, P; Thadathil, N; Tran, AL; Van Der Veldt, M; Wang, D; Wren, JD, 2023) |
| "NAFLD is typically associated with obesity and diabetes, however it also develops in lean individuals without metabolic syndrome." | 1.72 | Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice. ( Farazi, PA; Fisher, KW; Hymel, E; Vlock, E, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD), represents an unmet medical need that can progress to non-alcoholic steatohepatitis (NASH), which, without intervention, can result in the development of cirrhosis and hepatocellular carcinoma (HCC)." | 1.72 | IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models. ( Brightbill, HD; Ding, N; Flanagan, S; Ghilardi, N; Heredia, JE; Jones, C; Leong, L; Martinez, AP; Martzall, A; Nunez, V; Scherl, A; Sorenson, C, 2022) |
| "Nonalcoholic fatty liver disease affects about 24% of the world's population and may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC)." | 1.72 | Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma. ( Farazi, PA; Fisher, KW; Hymel, E, 2022) |
| "A proportion of NAFLD patients develop hepatic inflammation, known as Non-Alcoholic Steatohepatitis (NASH), which can end up in cirrhosis, or Hepatocellular Carcinoma (HCC)." | 1.56 | Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet. ( Angulo, S; Carril, E; Godzien, J; Lanzón, B; Rupérez, FJ; Valdecantos, MP; Valverde, ÁM, 2020) |
| "Choline deficiency has been well studied in the context of liver disease; however, less is known about the effects of choline supplementation in HCC." | 1.56 | Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. ( Allende, DS; Brown, AL; Conrad, K; Gromovsky, AD; Helsley, RN; Neumann, CK; Owens, AP; Tranter, M; Zhang, R, 2020) |
| "A 76-year-old man, who experienced prostate cancer biochemical relapse after 12 years from radical prostatectomy, underwent abdominal CT scan for restaging purposes, negative for metastases, and then C-choline PET/CT." | 1.56 | Incidental Finding on 11C-Choline-PET/CT of Hepatocellular Carcinoma Recurrence in a Prostate Cancer Patient With Negative Abdominal CT Scan. ( Boero, M; Guglielmo, P; Pisu, N; Pung, BLJ; Sanna, S, 2020) |
| "Choline is an essential nutrient required for normal neuronal and muscular development, as well as homeostatic regulation of hepatic metabolism." | 1.56 | In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism. ( Crawley, AM; Fullerton, MD; Ghorbani, P; Gobeil Odai, K; Han, S; Langlois, MA; O'Dwyer, C; Pezacki, JP; Renner, TM; Rezaaifar, M; Russell, RS; Shaw, TA; Steenbergen, R; Tyrrell, DL, 2020) |
| "Pioglitazone is an effective agent for chemoprevention in rodents and could be repurposed as a multi-targeted drug for delaying liver fibrosis and hepatocarcinogenesis." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "In a nutritional model of hepatocarcinogenesis, the protein Nrf2 is frequently mutated/activated at early steps of the tumorigenic process." | 1.48 | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. ( Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P, 2018) |
| "There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents." | 1.46 | Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017) |
| "Diagnosis of recurrent hepatocellular carcinoma (HCC) is sometimes challenging, especially when extrahepatic disease is present." | 1.43 | Recurrent Extrahepatic Hepatocellular Carcinoma Detected by 18F-Choline PET/CT. ( Geier, A; Götze, O; Lapa, C; Schmid, JS; Weiss, J, 2016) |
| "Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer." | 1.43 | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. ( Egger, M; Eggert, T; ElGindi, M; Felsher, DW; Greten, TF; Han, M; Heikenwalder, M; Jin, P; Kapoor, V; Kesarwala, AH; Kleiner, DE; Luo, J; Ma, C; McVicar, DW; Medina-Echeverz, J; Stroncek, DF; Terabe, M; Thornton, AM; Weber, A; Zhang, H, 2016) |
| "Hepatoblastoma is a rare carcinoma mostly seen in children." | 1.39 | Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT. ( Bennink, RJ; Bieze, M; van Gulik, TM, 2013) |
| "Choline was significantly increased in tumor tissue; lysophosphatidylcholine (LPC) was increased within bile while LPA was increased in all three biological samples of HCC patients compared with controls." | 1.37 | Hepatocellular carcinoma associated lipid metabolism reprogramming. ( Maluccio, MA; Scott, RE; Skill, NJ; Wu, J, 2011) |
| "MRS observation on liver cancer after transcatheter arterial chemoembolization (TACE) has seldom been reported." | 1.36 | Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization. ( Bian, DJ; Chen, XY; Hu, DX; Situ, WJ; Sun, JL; Xiao, EH; Yang, LP; Yuan, SW, 2010) |
| " These results indicate that long-term administration of rh-HGF does not accelerate hepatocarcinogenesis in rats fed a CDAA diet." | 1.33 | Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet. ( Abe, H; Akiyama, Y; Hasuike, S; Ido, A; Kataoka, H; Kim, ID; Kusumoto, K; Moriuchi, A; Nagata, K; Nakanishi, C; Numata, M; Tsubouchi, H; Uto, H, 2006) |
| "In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development." | 1.31 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002) |
| "While the first hepatocellular carcinoma in R16 fed either a CS or LC was seen at 9-10 months, one R16 rat fed a CD diet had liver cancer at 4 months." | 1.28 | Genetics and diet: synergism in hepatocarcinogenesis in rats. ( Gill, TJ; Kazanecki, ME; Kunz, HW; Melhem, MF; Rao, KN, 1990) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| "Choline was not effective in inhibiting the development of lung metastases in either case." | 1.27 | Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986) |
| "Methionine was contained in both the amino acid and the lipotrope supplement and probably was responsible for reducing hepatocarcinoma incidence." | 1.26 | Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet. ( Rogers, AE, 1977) |
| "Populations of Novikoff rat hepatoma cells (subline N1S1-67) were monitored for the rates of transport of various substrates and for their incorporation into acid-insoluble material as a function of the age of cultures of randomly growing cells in suspension as well as during traverse of the cells through the cell cycle." | 1.25 | Cell cycle and growth stage-dependent changes in the transport of nucleosides, hypoxanthine, choline, and deoxyglucose in cultured Novikoff rat hepatoma cells. ( Erbe, J; Plagemenn, PG; Richey, DP; Zylka, JM, 1975) |
| "Infection of Novikoff rat hepatoma cells (subline NlSL-67) with mengovirus resulted in a two- to threefold increase in the rate of choline incorporation into membrane phosphatidylcholine at about 3 hr after infection, without affecting the rate of transport of choline into the cell or its phosphorylation." | 1.25 | Effect of mengovirus replication on choline metabolism and membrane formation in novikoff hepatoma cells. ( Cleveland, PH; Plagemann, PG; Shea, MA, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (28.19) | 18.7374 |
| 1990's | 8 (5.37) | 18.2507 |
| 2000's | 26 (17.45) | 29.6817 |
| 2010's | 48 (32.21) | 24.3611 |
| 2020's | 25 (16.78) | 2.80 |
| Authors | Studies |
|---|---|
| Ohtani, N | 1 |
| Hara, E | 1 |
| Men, H | 1 |
| Young, JL | 1 |
| Zhou, W | 1 |
| Zhang, H | 3 |
| Wang, X | 1 |
| Xu, J | 1 |
| Lin, Q | 1 |
| Tan, Y | 1 |
| Zheng, Y | 1 |
| Cai, L | 1 |
| Boycott, C | 1 |
| Beetch, M | 1 |
| Yang, T | 2 |
| Lubecka, K | 1 |
| Ma, Y | 1 |
| Zhang, J | 1 |
| Kurzava Kendall, L | 1 |
| Ullmer, M | 1 |
| Ramsey, BS | 1 |
| Torregrosa-Allen, S | 1 |
| Elzey, BD | 1 |
| Cox, A | 1 |
| Lanman, NA | 1 |
| Hui, A | 1 |
| Villanueva, N | 1 |
| de Conti, A | 1 |
| Huan, T | 1 |
| Pogribny, I | 1 |
| Stefanska, B | 1 |
| Zhang, Y | 1 |
| Ye, S | 1 |
| Lu, W | 1 |
| Zhong, J | 1 |
| Leng, Y | 1 |
| Luo, J | 2 |
| Xu, W | 1 |
| Kong, L | 1 |
| Hymel, E | 3 |
| Vlock, E | 1 |
| Fisher, KW | 3 |
| Farazi, PA | 3 |
| Heredia, JE | 1 |
| Sorenson, C | 1 |
| Flanagan, S | 1 |
| Nunez, V | 1 |
| Jones, C | 1 |
| Martzall, A | 1 |
| Leong, L | 1 |
| Martinez, AP | 1 |
| Scherl, A | 1 |
| Brightbill, HD | 1 |
| Ghilardi, N | 1 |
| Ding, N | 1 |
| Sönmez, RE | 1 |
| Besson, FL | 2 |
| Ghidaglia, J | 1 |
| Lewin, M | 1 |
| Gomez, L | 1 |
| Salloum, C | 1 |
| Pittau, G | 1 |
| Ciacio, O | 1 |
| Allard, MA | 1 |
| Cherqui, D | 1 |
| Adam, R | 1 |
| Sa Cunha, A | 1 |
| Azoulay, D | 2 |
| Vibert, E | 1 |
| Golse, N | 2 |
| Faudemer, J | 1 |
| Meriaux, E | 1 |
| Tillou, X | 1 |
| Aide, N | 1 |
| Giri, SR | 1 |
| Bhoi, B | 1 |
| Trivedi, C | 1 |
| Rath, A | 1 |
| Rathod, R | 1 |
| Sharma, A | 1 |
| Ranvir, R | 1 |
| Kadam, S | 1 |
| Ingale, K | 1 |
| Patel, H | 1 |
| Nyska, A | 1 |
| Jain, MR | 1 |
| Sivapathasundaram, A | 1 |
| Pascale, A | 1 |
| Durand, E | 1 |
| Sebagh, M | 1 |
| Gnocchi, D | 1 |
| Afonso, MB | 2 |
| Cavalluzzi, MM | 1 |
| Lentini, G | 1 |
| Ingravallo, G | 1 |
| Sabbà, C | 1 |
| Rodrigues, CMP | 2 |
| Mazzocca, A | 1 |
| Mohammed, S | 1 |
| Thadathil, N | 1 |
| Ohene-Marfo, P | 1 |
| Tran, AL | 1 |
| Van Der Veldt, M | 1 |
| Georgescu, C | 1 |
| Oh, S | 1 |
| Nicklas, EH | 1 |
| Wang, D | 2 |
| Haritha, NH | 1 |
| Luo, W | 1 |
| Janknecht, R | 1 |
| Miller, BF | 1 |
| Wren, JD | 1 |
| Freeman, WM | 1 |
| Deepa, SS | 1 |
| Rodrigues, PM | 1 |
| Simão, AL | 1 |
| Islam, T | 1 |
| Gaspar, MM | 1 |
| O'Rourke, CJ | 1 |
| Lewinska, M | 1 |
| Andersen, JB | 1 |
| Arretxe, E | 1 |
| Alonso, C | 1 |
| Santos-Laso, Á | 1 |
| Izquierdo-Sanchez, L | 1 |
| Jimenez-Agüero, R | 1 |
| Eizaguirre, E | 1 |
| Bujanda, L | 1 |
| Pareja, MJ | 1 |
| Prip-Buus, C | 1 |
| Banales, JM | 1 |
| Castro, RE | 1 |
| Suzuki-Kemuriyama, N | 1 |
| Abe, A | 1 |
| Nakane, S | 1 |
| Yuki, M | 1 |
| Miyajima, K | 1 |
| Nakae, D | 3 |
| Carril, E | 1 |
| Valdecantos, MP | 1 |
| Lanzón, B | 1 |
| Angulo, S | 1 |
| Valverde, ÁM | 1 |
| Godzien, J | 1 |
| Rupérez, FJ | 1 |
| Brown, AL | 1 |
| Conrad, K | 1 |
| Allende, DS | 1 |
| Gromovsky, AD | 1 |
| Zhang, R | 1 |
| Neumann, CK | 1 |
| Owens, AP | 1 |
| Tranter, M | 1 |
| Helsley, RN | 1 |
| Gobeil Odai, K | 1 |
| O'Dwyer, C | 1 |
| Steenbergen, R | 1 |
| Shaw, TA | 1 |
| Renner, TM | 1 |
| Ghorbani, P | 1 |
| Rezaaifar, M | 1 |
| Han, S | 1 |
| Langlois, MA | 1 |
| Crawley, AM | 1 |
| Russell, RS | 1 |
| Pezacki, JP | 1 |
| Tyrrell, DL | 1 |
| Fullerton, MD | 1 |
| Gougelet, A | 1 |
| Colnot, S | 1 |
| Mulé, S | 1 |
| Chalaye, J | 3 |
| Legou, F | 1 |
| Tenenhaus, A | 1 |
| Calderaro, J | 2 |
| Galletto Pregliasco, A | 1 |
| Laurent, A | 1 |
| Kharrat, R | 1 |
| Amaddeo, G | 2 |
| Regnault, H | 1 |
| Tacher, V | 1 |
| Kobeiter, H | 1 |
| Itti, E | 2 |
| Luciani, A | 3 |
| Guglielmo, P | 1 |
| Pisu, N | 1 |
| Sanna, S | 1 |
| Pung, BLJ | 1 |
| Boero, M | 1 |
| Liu, ZY | 1 |
| Zhang, DM | 1 |
| Yishake, D | 1 |
| Luo, Y | 1 |
| Fang, AP | 1 |
| Zhu, HL | 2 |
| Haberl, EM | 2 |
| Pohl, R | 2 |
| Rein-Fischboeck, L | 2 |
| Höring, M | 1 |
| Krautbauer, S | 2 |
| Liebisch, G | 1 |
| Buechler, C | 2 |
| Aujay, G | 1 |
| Debordeaux, F | 1 |
| Blanc, JF | 1 |
| Lapuyade, B | 1 |
| Papadopoulos, P | 1 |
| Bordenave, L | 1 |
| Trillaud, H | 1 |
| Pinaquy, JB | 1 |
| Evangelista, L | 1 |
| Giacomuzzi, F | 1 |
| Di Gregorio, F | 1 |
| Rensi, M | 1 |
| Zhou, RF | 1 |
| Chen, XL | 1 |
| Zhou, ZG | 1 |
| Zhang, YJ | 1 |
| Lan, QY | 1 |
| Liao, GC | 1 |
| Chen, YM | 1 |
| Zeisel, S | 1 |
| Nakamura, M | 1 |
| Suetsugu, A | 2 |
| Hasegawa, K | 1 |
| Matsumoto, T | 1 |
| Aoki, H | 1 |
| Kunisada, T | 1 |
| Shimizu, M | 1 |
| Saji, S | 1 |
| Moriwaki, H | 1 |
| Hoffman, RM | 1 |
| Lanza, E | 2 |
| Donadon, M | 2 |
| Felisaz, P | 1 |
| Mimmo, A | 1 |
| Chiti, A | 3 |
| Torzilli, G | 2 |
| Balzarini, L | 1 |
| Lopci, E | 2 |
| Ikawa-Yoshida, A | 1 |
| Matsuo, S | 1 |
| Kato, A | 1 |
| Ohmori, Y | 1 |
| Higashida, A | 1 |
| Kaneko, E | 1 |
| Matsumoto, M | 1 |
| Ghedini, P | 1 |
| Bossert, I | 1 |
| Zanoni, L | 1 |
| Ceci, F | 1 |
| Graziani, T | 1 |
| Castellucci, P | 1 |
| Ambrosini, V | 1 |
| Massari, F | 1 |
| Nobili, E | 1 |
| Melotti, B | 1 |
| Musto, A | 1 |
| Zoboli, S | 1 |
| Antunovic, L | 1 |
| Kirienko, M | 1 |
| Mosconi, C | 1 |
| Ardizzoni, A | 1 |
| Golfieri, R | 1 |
| Fanti, S | 1 |
| Nanni, C | 1 |
| Costentin, CE | 2 |
| Ganne-Carrié, N | 1 |
| Baranes, L | 1 |
| Allaire, M | 1 |
| Nahon, P | 1 |
| Seror, O | 1 |
| Mallat, A | 1 |
| Soussan, M | 1 |
| Duvoux, C | 1 |
| Nault, JC | 2 |
| Hartenbach, M | 2 |
| Weber, S | 2 |
| Pilz, M | 1 |
| Hartenbach, S | 2 |
| Zacherl, MJ | 2 |
| Paprottka, PM | 2 |
| Tiling, R | 2 |
| Bartenstein, P | 2 |
| Hacker, M | 2 |
| Haug, AR | 2 |
| Albert, NL | 2 |
| Orrù, C | 1 |
| Szydlowska, M | 1 |
| Taguchi, K | 1 |
| Zavattari, P | 1 |
| Perra, A | 1 |
| Yamamoto, M | 1 |
| Columbano, A | 1 |
| Noordzij, W | 1 |
| de Jong, KP | 1 |
| de Meijer, VE | 1 |
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| Arora, G | 1 |
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| Yuan, JM | 1 |
| Bieze, M | 5 |
| Klümpen, HJ | 1 |
| Verheij, J | 3 |
| Beuers, U | 2 |
| Phoa, SS | 3 |
| van Gulik, TM | 5 |
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| Ogawa, S | 1 |
| Iio, E | 1 |
| Isogawa, M | 1 |
| Shimada, N | 1 |
| Komori, A | 1 |
| Toyoda, H | 1 |
| Kumada, T | 1 |
| Namisaki, T | 1 |
| Yoshiji, H | 2 |
| Sakamoto, N | 1 |
| Nakagawa, M | 1 |
| Asahina, Y | 1 |
| Kurosaki, M | 1 |
| Izumi, N | 1 |
| Enomoto, N | 1 |
| Kusakabe, A | 1 |
| Kajiwara, E | 1 |
| Itoh, Y | 1 |
| Ide, T | 1 |
| Tamori, A | 1 |
| Matsubara, M | 1 |
| Kawada, N | 1 |
| Shirabe, K | 1 |
| Tomita, E | 1 |
| Honda, M | 1 |
| Kaneko, S | 1 |
| Nishina, S | 1 |
| Hiasa, Y | 1 |
| Watanabe, H | 1 |
| Genda, T | 1 |
| Sakaida, I | 2 |
| Nishiguchi, S | 1 |
| Takaguchi, K | 1 |
| Tanaka, E | 1 |
| Sugihara, J | 1 |
| Shimada, M | 1 |
| Kondo, Y | 1 |
| Kawai, Y | 1 |
| Kojima, K | 1 |
| Nagasaki, M | 1 |
| Tokunaga, K | 1 |
| Tanaka, Y | 1 |
| Zhang, Q | 1 |
| Gao, J | 1 |
| Li, L | 1 |
| Chen, HB | 1 |
| Li, XQ | 1 |
| Yan, XZ | 1 |
| Nishiyama, Y | 1 |
| Kameyama, R | 1 |
| Okano, K | 1 |
| Kashiwagi, H | 1 |
| Deguchi, A | 1 |
| Kaji, M | 1 |
| Ohkawa, M | 1 |
| JAFFE, WG | 1 |
| Southam, AD | 1 |
| Easton, JM | 1 |
| Stentiford, GD | 1 |
| Ludwig, C | 1 |
| Arvanitis, TN | 1 |
| Viant, MR | 1 |
| Skill, NJ | 1 |
| Scott, RE | 1 |
| Wu, J | 1 |
| Maluccio, MA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diagnostic and Prognostic Role of 11C-Choline PET/CT and DWI MRI for Response Assessment in Patients Affected by Hepatocellular Carcinoma (HCC) and Candidate to TARE[NCT02519075] | 14 participants (Actual) | Observational | 2015-04-30 | Completed | |||
| What is the Prognostic Value of ¹¹C-choline PET/CT in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma?[NCT03430635] | 40 participants (Actual) | Observational | 2010-01-01 | Completed | |||
| Evaluation of 11 C-Choline PET-CT for Detection of Hepatocellular Carcinoma[NCT01377220] | Phase 2 | 30 participants (Anticipated) | Interventional | 2011-06-30 | Not yet recruiting | ||
| Prospective Evaluation of Tumor Response to Cancer Treatment Therapies[NCT02787954] | 10 participants (Actual) | Observational [Patient Registry] | 2016-01-31 | Terminated (stopped due to PI transferred to another institution and did not take this study with him.) | |||
| The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD[NCT05200156] | 100 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | |||
| Cancer Localization in the Prostate With F-18 Fluorocholine Positron Emission Tomography[NCT01310192] | Phase 1 | 20 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for choline and Liver Neoplasms
| Article | Year |
|---|---|
Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota.
Topics: Bile Acids and Salts; Carcinoma, Hepatocellular; Cellular Senescence; Choline; DNA Damage; Ethanol; | 2021 |
Choline, Other Methyl-Donors and Epigenetics.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cyclin-Dependent Kinase Inhibit | 2017 |
PET with (18)F-labelled choline-based tracers for tumour imaging: a review of the literature.
Topics: Brain Neoplasms; Choline; Humans; Liver Neoplasms; Male; Neoplasms; Positron-Emission Tomography; Pr | 2010 |
In vivo magnetic resonance spectroscopy of liver tumors and metastases.
Topics: Carbon Isotopes; Choline; Ethanolamine; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Ne | 2011 |
Cancer imaging with fluorine-18-labeled choline derivatives.
Topics: Brain Neoplasms; Carcinoma, Hepatocellular; Choline; Esophageal Neoplasms; Female; Fluorine Radioiso | 2007 |
Methionine metabolism and liver disease.
Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Humans; Liver Diseases; Liver Neoplasms | 2008 |
The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.
Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplas | 1996 |
Labile methyl groups and the promotion of cancer.
Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic | 1986 |
Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; Cell Transfo | 1974 |
6 trials available for choline and Liver Neoplasms
| Article | Year |
|---|---|
Diagnostic accuracy of (18) F-methylcholine positron emission tomography/computed tomography for intra- and extrahepatic hepatocellular carcinoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bile Ducts, Extrahepatic; Bile Ducts, Intrahepatic; Carc | 2014 |
1H Magnetic Resonance Spectroscopy Predicts Hepatocellular Carcinoma in a Subset of Patients With Liver Cirrhosis: A Randomized Trial.
Topics: Adult; Carcinoma, Hepatocellular; Choline; Hepatitis B, Chronic; Humans; Lipids; Liver Cirrhosis; Li | 2015 |
Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT.
Topics: Adenoma, Liver Cell; Adult; Biological Transport; Choline; Diagnosis, Differential; Female; Focal No | 2011 |
Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Differentiation; Choline; Chronic Disease; Fem | 2010 |
A pilot comparison of 18F-fluorodeoxyglucose and 18F-fluorocholine PET/CT to predict early recurrence of unifocal hepatocellular carcinoma after surgical resection.
Topics: Aged; Carcinoma, Hepatocellular; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Hum | 2012 |
The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy.
Topics: Adenoma, Liver Cell; Adult; Aged; Choline; Diagnosis, Differential; Female; Focal Nodular Hyperplasi | 2013 |
134 other studies available for choline and Liver Neoplasms
| Article | Year |
|---|---|
Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer.
Topics: Animals; Animals, Newborn; Cadmium; Choline; Diet, High-Fat; Diethylnitrosamine; Disease Models, Ani | 2021 |
Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; DNA; DNA Methylation; Epigenesis, Genetic; | 2022 |
RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling.
Topics: Animals; Carcinoma, Hepatocellular; Choline; DEAD-box RNA Helicases; Diet, High-Fat; Disease Models, | 2023 |
Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice.
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Diet, High-Fat; Disease Models, Animal; Di | 2022 |
IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Disease Models, Animal; Hepatitis; Inflamm | 2022 |
Towards refining the utility of dual (18F-FDG / 18F-Choline) PET/CT for the management of hepatocellular carcinoma: a tertiary center study.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Choline; Fluorodeoxyglucose F18; Humans; Liver Neopla | 2023 |
Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Fructose; Liver Neoplasms; Mice; Non-alcoh | 2022 |
Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Fructose; Liver Neoplasms; Mice; Non-alcoh | 2022 |
Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Fructose; Liver Neoplasms; Mice; Non-alcoh | 2022 |
Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Fructose; Liver Neoplasms; Mice; Non-alcoh | 2022 |
Normalization of Liver Physiological Uptake as a Response Marker to Treatment in Prostate Cancer Liver Metastases Appearing as Photopenic on Baseline 18F-Fluorocholine PET/CT.
Topics: Bone Neoplasms; Choline; Humans; Liver Neoplasms; Male; Middle Aged; Positron Emission Tomography Co | 2023 |
Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Diethylnitrosamine; Diseas | 2023 |
Is 18 F-FDG/ 18 F-Choline Dual-Tracer PET Behavior a Surrogate of Tumor Differentiation in Hepatocellular Carcinoma : A Tertiary Center Dedicated Study.
Topics: Carcinoma, Hepatocellular; Choline; Fluorodeoxyglucose F18; Humans; Liver Neoplasms; Neoplasm Recurr | 2023 |
Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline-deficient l-amino acid-defined diet prevents hepatocarcinogenesis in mice.
Topics: Amino Acids; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Choline Deficiency; Diet; | 2023 |
Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis.
Topics: Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Female; Incidence; Inflammation; Liver; | 2023 |
miR-21-5p promotes NASH-related hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Liver; Liver Neoplasms; Mice; MicroRNAs | 2023 |
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline D | 2023 |
Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatectomy; Lipid Metabolism; Liver; Liver Neoplasm | 2020 |
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice.
Topics: Animals; Betaine; Choline; Diet, High-Fat; Dietary Supplements; DNA, Mitochondrial; Fatty Liver; Gen | 2020 |
In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism.
Topics: Antigens, CD; Carcinoma, Hepatocellular; Cell Line, Tumor; Choline; Culture Media; Hepacivirus; Huma | 2020 |
[Metabolic imaging assessing choline addiction in liver primary cancers predicts their oncogenotype and opens a new therapeutic avenue].
Topics: Animals; beta Catenin; Carcinoma, Hepatocellular; Choline; Diagnostic Imaging; Gain of Function Muta | 2020 |
Hepatobiliary MR contrast agent uptake as a predictive biomarker of aggressive features on pathology and reduced recurrence-free survival in resectable hepatocellular carcinoma: comparison with dual-tracer 18F-FDG and 18F-FCH PET/CT.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Choline; Contrast Media; Disease-Free Sur | 2020 |
Incidental Finding on 11C-Choline-PET/CT of Hepatocellular Carcinoma Recurrence in a Prostate Cancer Patient With Negative Abdominal CT Scan.
Topics: Aged; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Humans; Incidental Findings; Liver N | 2020 |
Dietary choline, rather than betaine intake, is associated with hepatocellular carcinoma mortality.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Betaine; Carcinoma, Hepatocellular; China; Choline; Diet | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
18F-choline PET-computed tomography for the prediction of early treatment responses to transarterial radioembolization in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Choline; Embolization, Therapeutic; Glycolysis; Humans; Live | 2021 |
Skeletal Muscle Metastases in HCC Revealed by 18F-Choline PET/CT.
Topics: Aged; Carcinoma, Hepatocellular; Choline; Humans; Liver Neoplasms; Male; Muscle, Skeletal; Neoplasm | 2021 |
Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Betaine; Case-Control Studies; China; Choline; Diet; Fem | 2017 |
Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment.
Topics: Animals; Ascites; Bone Marrow; Cancer-Associated Fibroblasts; Cell Line, Tumor; Choline; Choline Def | 2017 |
Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline | 2017 |
Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline | 2017 |
Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline | 2017 |
Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline | 2017 |
Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Di | 2017 |
Liver metastases from prostate cancer at 11C-Choline PET/CT: a multicenter, retrospective analysis.
Topics: Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Humans; Liver Neoplasms; Male; Middle Aged; | 2018 |
Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Choline; Female; Fluorodeoxyglucose F18; Humans; Liver; Live | 2018 |
Combined [18F]-Fluoroethylcholine PET/CT and 99mTc-Macroaggregated Albumin SPECT/CT Predict Survival in Patients With Intermediate-Stage Hepatocellular Carcinoma.
Topics: Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Choline; Female; Humans; Liver Neoplasms; Male; | 2018 |
Reply to: "Response to: Positron emission tomography/computed tomography with
Topics: Carcinoma, Hepatocellular; Choline; Humans; Liver Neoplasms; Multimodal Imaging; Neoplasm Staging; P | 2018 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosa | 2018 |
Response to: Positron emission tomography/computed tomography with
Topics: Carcinoma, Hepatocellular; Choline; Humans; Liver Neoplasms; Multimodal Imaging; Neoplasm Staging | 2018 |
Hepatic Metastases From Prostatic Adenocarcinoma Without Elevated 18F-Choline Activity.
Topics: Adenocarcinoma; Aged; Biological Transport; Choline; Humans; Liver Neoplasms; Male; Positron Emissio | 2018 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
Arterial Phase 18F-Fluorocholine PET/CT in Hepatocellular Carcinoma.
Topics: Biological Transport; Carcinoma, Hepatocellular; Choline; Hepatic Artery; Humans; Liver Neoplasms; M | 2019 |
Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma.
Topics: Aged; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Choline; Cohort Studies; Humans; Liv | 2013 |
18F-fluorocholine may be taken-up by brown adipose tissue.
Topics: Adenoma; Adipose Tissue, Brown; Adult; Artifacts; Choline; Diagnosis, Differential; False Positive R | 2013 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M | 2014 |
Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans.
Topics: Acetylcarnitine; Adolescent; Adult; Africa, Western; Aged; Aged, 80 and over; alpha-Fetoproteins; Bi | 2014 |
Asymmetrical distribution of choline phospholipids revealed by click chemistry and freeze-fracture electron microscopy.
Topics: Carcinoma, Hepatocellular; Cell Membrane; Choline; Chromatography, Thin Layer; Click Chemistry; Cyto | 2014 |
The effects of methyl-donor deficiency on the pattern of gene expression in mice.
Topics: Animals; Choline; Deficiency Diseases; Diet; Female; Folic Acid; Gene Expression Regulation; Kidney; | 2015 |
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu | 2015 |
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu | 2015 |
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu | 2015 |
Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Hu | 2015 |
Evaluating Treatment Response of Radioembolization in Intermediate-Stage Hepatocellular Carcinoma Patients Using 18F-Fluoroethylcholine PET/CT.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Choline; Embolization, Therapeutic; Humans; Liver Neo | 2015 |
Diagnostic value of combining ¹¹C-choline and ¹⁸F-FDG PET/CT in hepatocellular carcinoma.
Topics: Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Fluorodeo | 2016 |
Recurrent Extrahepatic Hepatocellular Carcinoma Detected by 18F-Choline PET/CT.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Choline; Female; Fluorine Radioisotopes; Humans; Live | 2016 |
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Case-Control Studies; CD4-Positive T-Lymphocytes | 2016 |
Diagnosis of Hepatocellular Carcinoma Using C11 Choline PET/CT: Comparison with F18 FDG, ContrastEnhanced MRI and MDCT.
Topics: Adult; Carcinoma, Hepatocellular; Choline; Female; Fluorodeoxyglucose F18; Humans; Liver Neoplasms; | 2016 |
Diagnostic value of 3.0T (1)H MRS with choline-containing compounds ratio (∆CCC) in primary malignant hepatic tumors.
Topics: Adult; Aged; Case-Control Studies; Choline; Female; Humans; Liver Neoplasms; Magnetic Resonance Imag | 2016 |
Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.
Topics: Adenoma, Liver Cell; Carcinoma, Hepatocellular; Choline; Diagnosis, Differential; Female; Fluorine R | 2017 |
Application of Single Voxel 1H Magnetic Resonance Spectroscopy in Hepatic Benign and Malignant Lesions.
Topics: Adult; Aged; Choline; Contrast Media; Diagnosis, Differential; Female; Humans; Lipid Metabolism; Liv | 2016 |
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Topics: Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Choline; Diet, | 2017 |
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H | 2017 |
[Metabonomic study of blood plasma in the assessment of liver graft function].
Topics: Acetone; Alanine; Biomarkers; Blood Glucose; Carcinoma; Choline; Glutamine; Humans; Lactic Acid; Liv | 2007 |
Detection of hepatocellular carcinoma using 11C-choline PET: comparison with 18F-FDG PET.
Topics: Aged; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorod | 2008 |
The influence of sodium thiosulfate on experimental tumor induction.
Topics: Adenoma; Animals; Choline; Choline Deficiency; Humans; Liver; Liver Neoplasms; Neoplasms; Neoplasms, | 1948 |
Metabolic changes in flatfish hepatic tumours revealed by NMR-based metabolomics and metabolic correlation networks.
Topics: Adenoma; Animals; Choline; Computational Biology; Environment; False Positive Reactions; Flatfishes; | 2008 |
Hepatocellular carcinoma associated lipid metabolism reprogramming.
Topics: Bile; Carcinoma, Hepatocellular; Case-Control Studies; Choline; Gene Expression Profiling; Gene Expr | 2011 |
Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Choline; Female; Glucose; Gl | 2010 |
Transport and metabolism of radiolabeled choline in hepatocellular carcinoma.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cells, Cultured; Choline; Dinitrophenols; | 2010 |
Imaging lipid synthesis in hepatocellular carcinoma with [methyl-11c]choline: correlation with in vivo metabolic studies.
Topics: Animals; Betaine; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Choline Kinase; Choline- | 2011 |
PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Fasting; Hu | 2011 |
Multimodal assessment of early tumor response to chemotherapy: comparison between diffusion-weighted MRI, 1H-MR spectroscopy of choline and USPIO particles targeted at cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Choline; Dextrans; D | 2012 |
F-18 FDG in conjunction with 11C-choline PET/CT in the diagnosis of hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Hepatocellular; Choline; Female; Fl | 2011 |
Fast detection of choline-containing metabolites in liver using 2D ¹H-¹⁴N three-bond correlation (HN3BC) spectroscopy.
Topics: Algorithms; Biomarkers, Tumor; Choline; Female; Humans; Liver; Liver Neoplasms; Magnetic Resonance S | 2012 |
Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT.
Topics: Adolescent; Choline; Female; Hepatoblastoma; Humans; Liver Neoplasms; Multimodal Imaging; Positron-E | 2013 |
Involvement of phospholipids in the mechanism of insulin action in HEPG2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Choline; Chromatography, Thin Layer; Diglycerides; Extr | 2003 |
Liver carcinoma and related lesions in chronic choline deficiency.
Topics: Animals; Carcinoma, Hepatocellular; Choline; Choline Deficiency; Liver Cirrhosis, Experimental; Live | 1954 |
[Determining role of a simple nutritional factor in obtaining of certain liver cancers in rat Wistar intergrating a carcinogen p-dimethylaminoazobenzene].
Topics: Animals; Bile Ducts, Intrahepatic; Carcinogens; Choline; Fats; Liver Neoplasms; Neoplasms, Experimen | 1954 |
Hepatomas in choline deficiency.
Topics: Animals; Carcinoma, Hepatocellular; Choline; Choline Deficiency; Humans; Liver Neoplasms; Liver Neop | 1955 |
The effects of compounds related to choline on azo-dye carcinogenesis.
Topics: Amino Alcohols; Animals; Benzene; Benzene Derivatives; Carcinogenesis; Carcinoma, Hepatocellular; Ch | 1955 |
PHOSPHORUS COMPOUNDS IN ANIMAL TISSUES. VII. ENZYMATIC FORMATION OF DEOXYCYTIDINE DIPHOSPHATE CHOLINE AND LECITHIN BY TISSUE HOMOGENATES.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Choline; Chromatography; Cytosine Nucleotides; | 1963 |
INTRACELLULAR DISTRIBUTION OF ENZYMES. XIII. ENZYMATIC SYNTHESIS OF DEOXYCYTIDINE DIPHOSPHATE CHOLINE AND LECITHIN IN RAT LIVER.
Topics: Carbon Isotopes; Carcinoma, Hepatocellular; Chemistry Techniques, Analytical; Choline; Cytosine Nucl | 1963 |
On the qualitative change in the nature of choline plasmalogen in tumor tissues.
Topics: Carcinoma, Hepatocellular; Choline; Humans; Lipid Metabolism; Liver Neoplasms; Phospholipids; Plasma | 1960 |
Osteoactivin expressed during cirrhosis development in rats fed a choline-deficient, L-amino acid-defined diet, accelerates motility of hepatoma cells.
Topics: Aged; Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Movement; Choline; Clonin | 2003 |
The effect of choline deficiency on the development of tumors produced by butter yellow.
Topics: Choline; Choline Deficiency; Humans; Liver Neoplasms; Neoplasms; p-Dimethylaminoazobenzene | 1951 |
In vivo proton magnetic resonance spectroscopy of large focal hepatic lesions and metabolite change of hepatocellular carcinoma before and after transcatheter arterial chemoembolization using 3.0-T MR scanner.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Catheterization; Chemoembolization, Thera | 2004 |
Quantification of choline compounds in human hepatic tumors by proton MR spectroscopy at 3 T.
Topics: Brain; Carcinoma, Hepatocellular; Choline; Humans; Liver; Liver Neoplasms; Magnetic Resonance Imagin | 2005 |
In vivo detection of metabolic changes by 1H-MRS in the DEN-induced hepatocellular carcinoma in Wistar rat.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, Animal | 2005 |
Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes.
Topics: Animals; Apoptosis; Benzyl Compounds; Blotting, Western; Caspases; Cell Separation; Cells, Cultured; | 2005 |
Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Choline; Choline Deficiency; DNA Damage; DNA, Neoplas | 2005 |
Early response of hepatocellular carcinoma to transcatheter arterial chemoembolization: choline levels and MR diffusion constants--initial experience.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Catheterization; Chemoembolization, Thera | 2006 |
Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet.
Topics: Albumins; Amino Acids; Animal Feed; Animals; Choline; Hepatocyte Growth Factor; Humans; Liver Neopla | 2006 |
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv | 2006 |
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv | 2006 |
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv | 2006 |
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT.
Topics: Carcinoma, Hepatocellular; Choline; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Liv | 2006 |
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, | 2006 |
Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats.
Topics: Amino Acids; Animal Feed; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; DNA Mutat | 2007 |
Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Cyclic N-Oxides; D | 2007 |
Fluoromethylcholine PET in recurrent multifocal hepatoma.
Topics: Carcinoma, Hepatocellular; Choline; Female; Humans; Image Enhancement; Liver Neoplasms; Middle Aged; | 2007 |
Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model.
Topics: Animal Feed; Animals; Bone Marrow Cells; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2008 |
Analysis of acetylcholine, choline and butyrobetaine in human liver tissues by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Topics: Acetylcholine; Betaine; Carcinoma, Hepatocellular; Carnitine; Choline; Chromatography, Liquid; Human | 2008 |
Quantitative proton magnetic resonance spectroscopy of the normal liver and malignant hepatic lesions at 3.0 Tesla.
Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Choline; Female; Humans; Liver; Liver Neoplasms; Magneti | 2008 |
Modulation of tumor promotion in liver carcinogenesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Di | 1983 |
Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.
Topics: Animals; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neopl | 1982 |
Promotion of liver carcinogenesis in the rat by a choline-devoid diet: role of liver cell necrosis and regeneration.
Topics: Animals; Choline; Diet; DNA; Liver; Liver Neoplasms; Liver Regeneration; Male; Necrosis; Neoplasms, | 1982 |
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethy | 1980 |
Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency.
Topics: Amino Acid Sequence; Animals; Choline; DNA; Folic Acid; Gene Expression Regulation, Neoplastic; Gene | 1993 |
Phospholipid synthesis in the lymphomatous mouse liver studied by 31P nuclear magnetic resonance spectroscopy in vitro and by administration of 14C-radiolabelled compounds in vivo.
Topics: Animals; Body Weight; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Liver Neoplasms; L | 1993 |
Fibrosis accelerates the development of enzyme-altered lesions in the rat liver.
Topics: Actins; Amino Acids; Animals; Blood; Choline; Diet; Glutathione Transferase; Hydroxyproline; Liver; | 1998 |
Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; CpG Islands; Diet; DNA Methylation; Focal | 1999 |
Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; DNA-Binding Prot | 2001 |
Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells.
Topics: Animals; Choline; DNA; Hepatocytes; Humans; Liver Neoplasms; Mass Spectrometry; Methylation; Models, | 2002 |
Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Antic | 2002 |
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D | 2002 |
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.
Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; | 1975 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylni | 1977 |
Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet.
Topics: Alanine Transaminase; Albumins; alpha-Fetoproteins; Animals; Bilirubin; Cell Division; Choline; Diet | 1978 |
Cell cycle and growth stage-dependent changes in the transport of nucleosides, hypoxanthine, choline, and deoxyglucose in cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Choline; D | 1975 |
Role of DNA repair in natural resistance of rat ascites hepatomas to nitrogen mustard.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Choline; DNA Rep | 1977 |
Azaserine carcinogenesis: organ susceptibility change in rats fed a diet devoid of choline.
Topics: Animals; Azaserine; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Liver; Liver | 1978 |
Genetics and diet: synergism in hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Choline; Diet; Genes; Live | 1990 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Persistent reduction of indigenous DNA modification (I-compound) levels in liver DNA from male Fischer rats fed choline-devoid diet and in DNA of resulting neoplasms.
Topics: Animals; Autoradiography; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Diet; Diseas | 1990 |
1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity?
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diglycerides; Enzyme Activation; Glycerides; Live | 1989 |
Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets.
Topics: Animals; Body Weight; Choline; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; | 1986 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N | 1986 |
A lipotrope-dependent increase of histidase and urocanase in the livers of choline-deficient rats and in the Reuber H-35 transplanted hepatoma.
Topics: Ammonia-Lyases; Animals; Carcinoma, Hepatocellular; Choline; Choline Deficiency; Diet; Histidine Amm | 1973 |
Hepatorenal lesions in rats fed a low lipotrope diet and exposed to aflatoxin.
Topics: Aflatoxins; Animals; Autoradiography; Body Weight; Choline; Diet; DNA; Hyperplasia; Kidney; Lipids; | 1968 |
Phenethyl alcohol: reversible inhibition of synthesis of macromolecules and disaggregation of polysomes in rat hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Membrane Permeability; Centrifugation, Densi | 1968 |
Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. I. Incorporation of choline into phosphatidylcholine of mitochondria and other membranous structures and effect of metabolic inhibitors.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Membrane; Centrifugation, Density Gradient | 1968 |
[The lipid composition of microsomal fractions in the liver and hepatoma].
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Fatty Acids; In Vitro Techniques; Lipids; | 1968 |
[On the pathomorphology of tumors induced by benzocholine 69].
Topics: Adenocarcinoma; Adenoma; Animals; Benzene; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Choline; | 1969 |
Occurrence and nature of O-alkyl and O-alk-I-enyl moieties of glycerol in lipids of Morris transplanted hepatomas and normal rat liver.
Topics: Amino Alcohols; Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Chromatography, Gas; Chrom | 1969 |
Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. II. Phosphatidylcholine synthesis during growth cycle and fluctuation of mitochondrial density.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Membrane; Centri | 1969 |
Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cel | 1969 |
Effect of mengovirus replication on choline metabolism and membrane formation in novikoff hepatoma cells.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Membrane; Centrifugation, Density Gradient | 1970 |
Cytochalasin B. I. Effect on cytokinesis of Novikoff hepatoma cells.
Topics: Animals; Antineoplastic Agents; Benzocycloheptenes; Carcinoma, Hepatocellular; Cell Division; Cholin | 1971 |
Isotope dilution determinations and other studies of cytidine diphosphate choline, cytidine diphosphate ethanolamine, deoxycytidine diphosphate choline, and deoxycytidine diphosphate ethanolamine in liver and liver tumors.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Choline; Cytosine Nucleotides; | 1971 |
Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. 3. Choline transport and uptake by simple diffusion and lack of direct exchange with phosphatidylcholine.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Fractionation; Cell Line; Cell Membra | 1971 |
Cytochalasin B. VI. Competitive inhibition of nucleoside transport by cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cells, Cultured; Choline; DNA, Neoplasm; I | 1972 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic | 1973 |
Competitive inhibition of the transport of nucleosides, hypoxanthine, choline and deoxyglucose by theophylline, papaverine and prostaglandins.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Carcinoma, Hepatocellular; Cells, Cultu | 1974 |
Inhibition of transport systems in cultured rat hepatoma cells by colcemid and ethanol.
Topics: Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Choline; Colchicine; De | 1974 |
Cell population dynamics in the liver. A review of quantitative morphological techniques applied to the study of physiological and pathological growth.
Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Cholestasis; Choline; Deficiency Dis | 1966 |