Page last updated: 2024-10-16

choline and Liver Cirrhosis

choline has been researched along with Liver Cirrhosis in 149 studies

Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Research Excerpts

ExcerptRelevanceReference
"This prospective study aimed to compare the diagnostic performance of (18)F-fluorocholine and (18)F-FDG for detecting and staging hepatocellular carcinoma (HCC) in patients with chronic liver disease and suspected liver nodules."9.14Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease. ( Ancel, D; Balogova, S; Fartoux, L; Grange, JD; Gutman, F; Huchet, V; Kerrou, K; Nataf, V; Rosmorduc, O; Talbot, JN, 2010)
" In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver."8.31Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023)
"To study role of endoplasmic reticulum stress in the development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats."7.76[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. ( Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH, 2010)
"Pioglitazone treatment started at the first signs of fibrosis in both models."5.51Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019)
"Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks."5.36Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010)
"All CDD rats developed liver cirrhosis."5.35Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet. ( Anan, A; Irie, M; Iwata, K; Sakisaka, S; Shakado, S; Sohda, T; Takeyama, Y, 2008)
"In the presence of choline deficiency, absorption of intraluminal endotoxin may contribute to the development of fibrosis and cirrhosis."5.24INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT. ( BROITMAN, SA; GOTTLIEB, LS; ZAMCHECK, N, 1964)
"This prospective study aimed to compare the diagnostic performance of (18)F-fluorocholine and (18)F-FDG for detecting and staging hepatocellular carcinoma (HCC) in patients with chronic liver disease and suspected liver nodules."5.14Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease. ( Ancel, D; Balogova, S; Fartoux, L; Grange, JD; Gutman, F; Huchet, V; Kerrou, K; Nataf, V; Rosmorduc, O; Talbot, JN, 2010)
"The purpose of this study was to compare the spectral characteristics of lipids, choline-containing compounds, and glutamine-glutamate complex assessed with (1)H-MR spectroscopy with the histologic findings in patients with chronic hepatitis C."5.13Evaluation of the severity of chronic hepatitis C with 3-T1H-MR spectroscopy. ( Angelico, M; Bergamini, A; Bolacchi, F; Cadioli, M; Cozzolino, V; Orlacchio, A; Simonetti, G, 2008)
"In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) and choline (< 2 SDs from normal) with or without increased cerebral glutamine (> 1 SD from normal)--in 20 patients with cirrhosis."5.07Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. ( Ernst, T; Jacobson, S; Korula, J; Kreis, R; Moats, RA; Ross, BD; Shonk, T; Villamil, F, 1994)
"Humans eating diets low in choline develop fatty liver and liver damage."4.89Choline's role in maintaining liver function: new evidence for epigenetic mechanisms. ( Mehedint, MG; Zeisel, SH, 2013)
" In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver."4.31Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023)
"Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice."4.31Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023)
" Previously, we reported a dietary mouse NASH model with a choline-deficient, methionine-lowered, L-amino-acid-defined, high-fat diet containing shortening without trans fatty acids (CDAA-HF-T[-]), which rapidly induces fibrosis and proliferative lesions in the liver."4.31Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes. ( Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M, 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
" In the choline-deficient, L-amino acid-defined high-fat diet model of fibrotic NASH, myeloid-specific Nlrp3 knock-out but not hepatocyte- or HSC-specific knock-out mice showed significant reduction in inflammation independent of steatosis development."4.12Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. ( Booshehri, LM; Broderick, L; Feldstein, AE; Friess, H; Hartmann, D; Hoffman, HM; Kaufmann, B; Kim, AD; Kui, L; Leszczynska, A; Reca, A; Wree, A, 2022)
" The aim of the present study was to elucidate the role of the TLR4‑dependent signaling pathway, and examine the effect of pioglitazone on hepatic fibrosis, through modulation of the TLR4 pathway in a mouse model of nutritional fibrotic steatohepatitis."3.83TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice. ( Du, J; Kong, L; Nan, Y; Niu, X; Wang, R; Zhang, Y; Zhao, S, 2016)
"To study role of endoplasmic reticulum stress in the development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats."3.76[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. ( Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH, 2010)
"The mechanistic significance of oxidative stress to fibrogenesis in the methionine and choline-deficient (MCD) diet-induced model of steatohepatitis was evaluated by antioxidant intervention, using either vitamin E or L-2-oxothiazolidine-4-carboxylate (OTC), a cysteine precursor that promotes glutathione synthesis."3.75Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis. ( Farrell, G; George, J; Hou, JY; Leclercq, I; Pera, N; Phung, N, 2009)
"Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls."3.73In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006)
" Decreased myo-inositol and increased glutamine levels were noted to be the most sensitive spectroscopic markers for cirrhotic patients with hepatic encephalopathy (HE)."3.70Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve. ( Kim, ST; Lee, JH; Lee, YS; Lim, TH; Min, YI; Mun, CW; Seo, DW; Suh, DJ, 1999)
"Choline is a quaternary amine endogenously synthesized from the amino acid methionine or absorbed via the portal circulation."2.45The addition of choline to parenteral nutrition. ( Buchman, AL, 2009)
"Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes."2.39Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996)
"While NKT-cell involvement in steatohepatitis is debated, discrepancies may stem from varied mouse strains used, predominantly C57BL6/J with Th1-dominant responses."1.91Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice. ( Andrés-Sánchez, N; Colell, A; Cuño-Gómiz, C; de Gregorio, E; Marí, M; Morales, A; Rider, P; Tutusaus, A, 2023)
"However, the effect of ACT001 on nonalcoholic steatohepatitis (NASH) is unknown."1.91iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice. ( Chen, Z; Chu, W; Li, P; Liu, Y; Mi, Y; Niu, B; Wu, X; Zhou, H; Zhou, Y, 2023)
"Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC."1.91Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis. ( Deepa, SS; Freeman, WM; Georgescu, C; Haritha, NH; Janknecht, R; Luo, W; Miller, BF; Mohammed, S; Nicklas, EH; Oh, S; Ohene-Marfo, P; Thadathil, N; Tran, AL; Van Der Veldt, M; Wang, D; Wren, JD, 2023)
"Liver fibrosis is a chronic liver disease with the presence of progressive wound healing response caused by liver injury."1.91Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism. ( Chen, J; Dai, Z; Feng, T; Huang, X; Lai, C; Liang, Y; Shang, J; Shi, Y; Su, Y; Sun, L; Yan, S; Yang, Q; Yao, Y; Zhang, Z; Zhong, D; Zou, H, 2023)
"Chlorogenic acid (CGA) is a natural polyphenolic compound."1.72Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism. ( Guo, Q; Ji, L; Kai, G; Lu, B; Miao, H; Ouyang, H; Wei, M, 2022)
"Non-alcoholic fatty liver disease (NAFLD), represents an unmet medical need that can progress to non-alcoholic steatohepatitis (NASH), which, without intervention, can result in the development of cirrhosis and hepatocellular carcinoma (HCC)."1.72IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models. ( Brightbill, HD; Ding, N; Flanagan, S; Ghilardi, N; Heredia, JE; Jones, C; Leong, L; Martinez, AP; Martzall, A; Nunez, V; Scherl, A; Sorenson, C, 2022)
"The pathogenesis of liver fibrosis requires activation of hepatic stellate cells (HSCs); once activated, HSCs lose intracellular fatty acids but the role of fatty acid oxidation and carnitine palmitoyltransferase 1A (CPT1A) in this process remains largely unexplored."1.72Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis. ( Alonso, C; Crespo, J; Cubero, FJ; da Silva Lima, N; Delgado, TC; Dieguez, C; Fernandez, U; Filliol, AA; Fondevila, MF; Gonzalez-Rellan, MJ; Heras, V; Herrero, L; Iglesias, C; Iruzubieta, P; López, M; Martinez-Chantar, ML; Mato, JM; Mayo, R; Millet, O; Nogueiras, R; Novoa, E; Parracho, T; Porteiro, B; Prevot, V; Schwabe, RF; Schwaninger, M; Senra, A; Serra, D; Varela-Rey, M; Woodhoo, A, 2022)
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in western countries, with a continuously rising incidence."1.51Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis. ( Bennek, E; Candels, LS; Elfers, C; Gassler, N; Heymann, F; Kilic, K; Mohs, A; Penders, J; Schneider, KM; Schneider, LB; Trautwein, C, 2019)
"Pioglitazone treatment started at the first signs of fibrosis in both models."1.51Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019)
"There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents."1.46Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017)
"MCD diet resulted in steatohepatitis and increased miR-155 expression in total liver, hepatocytes and Kupffer cells."1.42MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. ( Bala, S; Catalano, D; Csak, T; Iracheta-Vellve, A; Kodys, K; Lippai, D; Szabo, G, 2015)
"Thereafter, liver injury, liver fibrosis and hepatocellular apoptosis were quantified in liver sections."1.40Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. ( Berk, M; Dixon, L; Feldstein, AE; Inzaugarat, ME; Papouchado, BG; Povero, D; Thapaliya, S; Wree, A, 2014)
"Non-alcoholic steatohepatitis (NASH), which represents advanced stage NAFLD, is increasingly being recognized as a major cause of liver-related morbidity and mortality."1.40Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis. ( Azuma, T; Hoshi, N; Kawano, Y; Minami, A; Nishiumi, S; Terashima, Y; Yoshida, M, 2014)
"Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis, lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of diabetes or hyperlipidemia, all in the absence of alcohol abuse."1.39Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation. ( Matsumoto, M; Miyamae, Y; Noto, T; Oishi, Y; Takeuchi-Yorimoto, A; Yamada, A, 2013)
"The pathogenesis of non-alcoholic steatohepatitis is still unclear."1.37Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. ( Han, F; Kong, LB; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, SX, 2011)
"Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks."1.36Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010)
"Nonalcoholic steatohepatitis is characterized by the association of steatosis with hepatic cell injury, lobular inflammation and fibrosis."1.36Curcumin limits the fibrogenic evolution of experimental steatohepatitis. ( Arena, U; Caligiuri, A; Delogu, W; Galastri, S; Laffi, G; Marra, F; Milani, S; Novo, E; Parola, M; Pinzani, M; Provenzano, A; Vizzutti, F; Zamara, E, 2010)
"All CDD rats developed liver cirrhosis."1.35Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet. ( Anan, A; Irie, M; Iwata, K; Sakisaka, S; Shakado, S; Sohda, T; Takeyama, Y, 2008)
"Patients who have liver cirrhosis are at increased risk of bacterial infections, such as bacteremia, meningitis, pneumonia, urinary tract infections, and spontaneous bacterial peritonitis, due to immunodeficiency associated with the severity of the cirrhosis."1.34Brain abscess in adult cirrhotic patients: two case reports. ( Chen, IY; Chung, CL; Howng, SL; Kwan, AL; Lieu, AS, 2007)
"Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma."1.34Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. ( Akisawa, N; Hirose, A; Iwasaki, S; Masuda, K; Nozaki, Y; Oben, JA; Onishi, S; Ono, M; Saibara, T; Takahashi, M; Yoshioka, A, 2007)
"Minimal hepatic encephalopathy (MHE) is frequently diagnosed in patients with liver cirrhosis who do not show overt clinical cirrhosis-associated neurological deficits."1.33Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy. ( Graziadei, IW; Hinterhuber, H; Kugener, A; Marksteiner, J; Mattedi, M; Mechtcheriakov, S; Schocke, M; Vogel, W, 2005)
"6 patients with liver cirrhosis were included in this pilot study."1.33[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)]. ( Gregor, M; Hass, HG; Hösl, F; Kaiser, S; Nägele, T; Seeger, U, 2005)
"The MCD model of 'fibrosing steatohepatitis' replicates the histologic features of human steatohepatitis, and the sequence of steatosis, inflammatory cell injury and fibrogenesis."1.32Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. ( Farrell, G; George, J; Leclercq, I; Pera, N; Phung, N; Yun Hou, J, 2003)
"In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development."1.31Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002)
"Hepatic encephalopathy is a common problem in cirrhosis."1.30Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. ( Andus, T; Feuerbach, S; Fründ, R; Geissler, A; Held, P; Hollerbach, S; Holstege, A; Lock, G; Schölmerich, J, 1997)
"The prevalence of plasma choline deficiency, i."1.28Choline may be an essential nutrient in malnourished patients with cirrhosis. ( Bonkovsky, HL; Chawla, RK; Kutner, MH; Wolf, DC, 1989)
"In the presence of choline deficiency, absorption of intraluminal endotoxin may contribute to the development of fibrosis and cirrhosis."1.24INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT. ( BROITMAN, SA; GOTTLIEB, LS; ZAMCHECK, N, 1964)
"The degree of liver cirrhosis was determined from specimens obtained at biopsy."1.23The relative effects of protein, choline, and methionine in the treatment of experimental dietary cirrhosis in the rat. ( BEVANS, M; PATEK, AJ; PLOUGH, IC, 1952)

Research

Studies (149)

TimeframeStudies, this research(%)All Research%
pre-199067 (44.97)18.7374
1990's5 (3.36)18.2507
2000's16 (10.74)29.6817
2010's29 (19.46)24.3611
2020's32 (21.48)2.80

Authors

AuthorsStudies
Zhang, C1
Zhang, B3
Chen, A2
Yin, Q1
Wang, H4
Fondevila, MF1
Fernandez, U1
Heras, V1
Parracho, T1
Gonzalez-Rellan, MJ1
Novoa, E1
Porteiro, B1
Alonso, C1
Mayo, R1
da Silva Lima, N1
Iglesias, C1
Filliol, AA1
Senra, A1
Delgado, TC1
Woodhoo, A1
Herrero, L1
Serra, D1
Prevot, V1
Schwaninger, M1
López, M1
Dieguez, C1
Millet, O1
Mato, JM1
Cubero, FJ1
Varela-Rey, M1
Iruzubieta, P1
Crespo, J1
Martinez-Chantar, ML1
Schwabe, RF2
Nogueiras, R1
Zhao, M1
Ma, L1
Honda, T1
Kato, A1
Ohshiro, T1
Yokoyama, S1
Yamamoto, K1
Ito, T1
Imai, N1
Ishizu, Y1
Nakamura, M1
Kawashima, H1
Tsuji, NM1
Ishigami, M1
Fujishiro, M1
Miao, H1
Ouyang, H1
Guo, Q1
Wei, M1
Lu, B1
Kai, G1
Ji, L1
Enomoto, M1
Kaji, K1
Nishimura, N1
Fujimoto, Y1
Murata, K1
Takeda, S1
Tsuji, Y1
Fujinaga, Y1
Takaya, H1
Kawaratani, H1
Namisaki, T2
Akahane, T1
Yoshiji, H3
Kaufmann, B1
Kui, L1
Reca, A1
Leszczynska, A1
Kim, AD1
Booshehri, LM1
Wree, A2
Friess, H1
Hartmann, D1
Broderick, L1
Hoffman, HM2
Feldstein, AE3
Guo, Y1
Xu, X3
Dong, H1
Shen, B1
Zhu, J1
Shen, Z2
Zhou, C1
Luo, X1
Qu, Y1
Cai, X1
Zhang, Q2
Lu, L1
Li, F1
Kong, W1
Tang, Y1
Liu, L3
Zhang, G2
Liu, Y4
Liu, J3
Heredia, JE1
Sorenson, C1
Flanagan, S1
Nunez, V1
Jones, C1
Martzall, A1
Leong, L1
Martinez, AP1
Scherl, A1
Brightbill, HD1
Ghilardi, N1
Ding, N1
Hu, J1
Zheng, Y1
Ying, H1
Ma, H1
Li, L3
Zhao, Y4
Xu, L1
Li, H3
Zhang, O1
Zhang, F1
Song, M1
Ma, M1
Ding, R1
Li, D1
Dong, Z1
Jin, S2
Han, W1
Ding, C1
Aljobaily, N1
Krutsinger, K1
Viereckl, MJ1
Joly, R1
Menlove, B1
Cone, B1
Suppes, A1
Han, Y1
Yang, L3
Zhang, H1
Dong, C1
Yue, W1
Xue, R1
Liu, F1
Zhang, Z1
Shang, J1
Yang, Q2
Dai, Z1
Liang, Y1
Lai, C1
Feng, T1
Zhong, D1
Zou, H1
Sun, L1
Su, Y1
Yan, S2
Chen, J4
Yao, Y2
Shi, Y1
Huang, X1
Oates, JR1
Sawada, K1
Giles, DA1
Alarcon, PC1
Damen, MSMA1
Szabo, S1
Stankiewicz, TE1
Moreno-Fernandez, ME1
Divanovic, S1
Nakamura, S1
Nakamura, K1
Yokoi, Y1
Shimizu, Y1
Ohira, S1
Hagiwara, M1
Song, Z1
Gan, L1
Aizawa, T1
Hashimoto, D1
Teshima, T1
Ouellette, AJ1
Ayabe, T1
Chaganti, J1
Zeng, G1
Tun, N1
Lockart, I1
Abdelshaheed, C1
Cysique, L1
Montagnese, S1
Brew, BJ1
Danta, M1
Mohammed, S1
Thadathil, N1
Ohene-Marfo, P1
Tran, AL1
Van Der Veldt, M1
Georgescu, C1
Oh, S1
Nicklas, EH1
Wang, D2
Haritha, NH1
Luo, W2
Janknecht, R1
Miller, BF1
Wren, JD1
Freeman, WM1
Deepa, SS1
Chu, H1
Zhang, W1
Tan, Y1
Diao, Z1
Li, P5
Wu, Y2
Xie, L2
Sun, J2
Yang, K3
Xie, C2
Hua, Q1
Povero, D2
Lazic, M1
McBride, C1
Ambrus-Aikelin, G1
Stansfield, R1
Johnson, CD1
Santini, AM1
Pranadinata, RF1
McGeough, MD1
Stafford, JA1
Veal, JM1
Bain, G1
Zhou, H1
Niu, B1
Wu, X1
Chu, W1
Zhou, Y1
Chen, Z1
Mi, Y1
Krzistetzko, J1
Géraud, C1
Dormann, C1
Riedel, A1
Leibing, T1
Suzuki-Kemuriyama, N2
Abe, A2
Nakane, S2
Yuki, M2
Miyajima, K2
Nakae, D2
Liu, X2
Fang, Y1
Qian, C1
Zuo, W1
Lin, J1
Liang, G1
Huang, L2
Wang, Y4
Cuño-Gómiz, C1
de Gregorio, E1
Tutusaus, A1
Rider, P1
Andrés-Sánchez, N1
Colell, A1
Morales, A1
Marí, M1
Yamauchi, A1
Tone, T1
Toledo, A1
Igarashi, K1
Sugimoto, K1
Miyai, H1
Deng, D1
Nakamura, J1
Lim, HS1
Kaku, T1
Hirano, E1
Shindo, T1
Takatani, N1
Kono, Y1
Beppu, F1
Okamatsu-Ogura, Y1
Yamano, Y1
Miyashita, K1
Hosokawa, M1
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J1
Zhang, J1
Shen, S1
Yu, WW1
Toyoda, H2
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Zhu, L1
Wang, J6
Xue, L1
Yan, X2
Huang, S1
Li, Y7
Xu, T1
Li, C2
Ji, F1
Ming, F1
Cheng, J1
Zhao, H1
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y4
Wei, J1
Zhu, C2
Wu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C3
Lin, Y2
Dong, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R2
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Yang, Y3
Lu, SH1
Lu, HZ1
Zhang, R2
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
Zeng, N1
Wang, L3
Yan, D1
Cui, L1
Zhai, C1
Yang, M1
Lao, X1
Ma, N1
Wang, S2
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
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Sugihara, J1
Shimada, M1
Kondo, Y1
Kawai, Y1
Kojima, K1
Nagasaki, M1
Tokunaga, K1
Tanaka, Y1
Wahlang, B1
Perkins, JT1
Petriello, MC1
Hoffman, JB1
Stromberg, AJ1
Hennig, B1
WADE, L2
NEUDORFF, L1
ENTENMAN, C1
CHAIKOFF, IL1
Phung, N2
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Farrell, G2
Leclercq, I2
Hou, JY1
George, J2
Buchman, AL1
Vizzutti, F1
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Galastri, S1
Milani, S1
Delogu, W1
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Laffi, G1
Parola, M1
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Marra, F1
Mu, YP2
Ogawa, T2
Kwada, N1
Xi, XH1
Chen, XR1
BURNS, LE1
FLEMING, JF1
PAUL, WD1
DAUM, K1
KEMP, CR2
Talbot, JN1
Fartoux, L1
Balogova, S1
Nataf, V1
Kerrou, K1
Gutman, F1
Huchet, V1
Ancel, D1
Grange, JD1
Rosmorduc, O1
Nan, YM1
Han, F1
Kong, LB1
Zhao, SX1
Wang, RQ1
Wu, WJ1
Yu, J1
BEAMS, AJ1
Handler, P1
Dubin, IN1
Ohyama, T1
Yamazaki, Y1
Sato, K1
Horiguchi, N1
Ichikawa, T1
Kakizaki, S1
Takagi, H1
Mori, M1
Al-Humadi, H1
Theocharis, S1
Dontas, I1
Stolakis, V1
Zarros, A1
Kyriakaki, A1
Al-Saigh, R1
Liapi, C1
Chavarria, L1
Alonso, J1
García-Martínez, R1
Simón-Talero, M1
Ventura-Cots, M1
Ramírez, C1
Torrens, M1
Vargas, V1
Rovira, A1
Córdoba, J1
Tsuchiya, M1
Kawaguchi, K1
Kimura, T1
Terai, S1
Okita, K1
ESH, GC1
GOVINDAN, KK1
RADHAKRISHNA RAO, MV1
PATEK, AJ3
PLOUGH, IC2
BEVANS, M2
PHILLIPS, GB1
DAVIDSON, CS1
GABUZDA, GJ1
GONZALEZ ALVAREZ, J2
VOLGAREV, MN2
SHAROVA, LS1
MEADER, RD1
OHTA, Y2
ZAKI, FG4
HOFFBAUER, FW4
KNAUFF, HG1
GEORGII, A1
MATZEN, K1
MARCHESI, E1
PADULA, F1
FRENCH, SW1
BLACK, B1
GOURLEY, WK1
PETZOLD, H2
LIEBOLD, G1
BROITMAN, SA2
GOTTLIEB, LS2
ZAMCHECK, N2
LEVIN, AS1
JEFFAY, H1
MADHAVAN, TV1
ITURRIAGA, H1
PIZZI, T1
UGARTE, G1
LORCA, F1
MASUKO, K1
RUBIN, E2
POPPER, H1
MACDONALD, RA3
PECHET, GS1
WINAWER, SJ1
BHATTACHARYYA, KK1
GAISFORD, WD1
ZUIDEMA, GD1
KENDALL, FE1
DEFRITSCH, NM1
HIRSCH, RL1
QUINN, PS1
HIGGINSON, J1
POZDNIAKOVA, AI1
Salmon, WD1
Newberne, PM1
Yun Hou, J1
Onaga, M1
Ido, A1
Hasuike, S1
Uto, H1
Moriuchi, A1
Nagata, K1
Hori, T1
Hayash, K1
Tsubouchi, H1
PELNER, L1
WALDMAN, S1
BERKE, J1
GULOTTA, C1
BUSSET, R1
DONHARDT, A1
Shawcross, DL1
Balata, S1
Olde Damink, SW1
Hayes, PC1
Wardlaw, J1
Marshall, I1
Deutz, NE1
Jalan, R1
CORNATZER, WE2
CAYER, D2
JAFFE, ER1
WISSLER, RW1
BENDITT, EP1
HARTMANN, F1
LEUSCHNER, F1
Mechtcheriakov, S1
Schocke, M1
Kugener, A1
Graziadei, IW1
Mattedi, M1
Hinterhuber, H1
Vogel, W1
Marksteiner, J1
Hass, HG1
Nägele, T1
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Hösl, F1
Gregor, M1
Kaiser, S1
Tesiram, YA1
Saunders, D1
Towner, RA1
Xu, H1
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Xie, JX1
Chung, CL1
Lieu, AS1
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Kwan, AL1
Howng, SL1
Yamaguchi, K1
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Huang, J1
Yu, XX1
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Ono, M1
Saibara, T1
Nozaki, Y1
Masuda, K1
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Takahashi, M1
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Iwasaki, S1
Oben, JA1
Onishi, S1
Iwata, K1
Sohda, T1
Irie, M1
Takeyama, Y1
Anan, A1
Shakado, S1
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Cozzolino, V1
Angelico, M1
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Szczudrawa, J1
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Kirchmayer, S1
Menninger, U1
Menninger, W1
Ross, BD2
Jacobson, S1
Villamil, F1
Korula, J1
Kreis, R1
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Hodgson, HJ1
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Marks, R1
Dudley, F1
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Chawla, RK2
Wolf, DC1
Kutner, MH2
Bonkovsky, HL1
Berry, CJ1
Rudman, D1
Lieber, CS1
Wildhirt, E1
Knick, B1
Ottenjann, R1
Gruner, J1
Kanzler, G1
Beary, ME1
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Fiedler, H1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Statins for Prevention of Disease Progression and Hospitalization in Liver Cirrhosis: A Multi-center, Randomized, Double Blind, Placebo-controlled Trial. The STATLiver Trial[NCT04072601]Phase 478 participants (Actual)Interventional2019-11-08Terminated (stopped due to Study part one completed)
The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD[NCT05200156]100 participants (Anticipated)Interventional2022-02-01Recruiting
Evaluation of 11 C-Choline PET-CT for Detection of Hepatocellular Carcinoma[NCT01377220]Phase 230 participants (Anticipated)Interventional2011-06-30Not yet recruiting
Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205]40 participants (Anticipated)Observational2019-06-01Recruiting
A Magnetic Resonance Spectroscopy Study of Neuropsychiatric Effects Associated With Cytokines[NCT00001547]150 participants Observational1996-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for choline and Liver Cirrhosis

ArticleYear
Stratifying Non-alcoholic Steatohepatitis With the Non-invasive Ultrasound Markers Shear Wave Dispersion Slope and Shear Wave Velocity: An Animal Study.
    Ultrasound in medicine & biology, 2022, Volume: 48, Issue:12

    Topics: Animals; Biomarkers; Choline; Fibrosis; Liver; Liver Cirrhosis; Male; Methionine; Non-alcoholic Fatt

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:3

    Topics: Animals; Choline; Diet; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Folic Acid; Gene Expressi

2013
The addition of choline to parenteral nutrition.
    Gastroenterology, 2009, Volume: 137, Issue:5 Suppl

    Topics: Aged; Burns; Child; Choline; Choline Deficiency; Female; Humans; Lactation; Liver Cirrhosis; Liver D

2009
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy?
    Digestive diseases (Basel, Switzerland), 1996, Volume: 14 Suppl 1

    Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic

1996
Hepatic cholesterol and cirrhosis in rats.
    Nutrition reviews, 1967, Volume: 25, Issue:11

    Topics: Animals; Cholesterol; Choline; Liver; Liver Cirrhosis; Rats

1967
Alcoholic fatty liver.
    The New England journal of medicine, 1969, Mar-27, Volume: 280, Issue:13

    Topics: Adult; Alcoholism; Animals; Child; Choline; Diet; Dietary Fats; Dietary Proteins; Drug Synergism; Et

1969
Alleviation of dietary cirrhosis by betaine and other lipotropic agents.
    Nutrition reviews, 1969, Volume: 27, Issue:9

    Topics: Animals; Betaine; Body Weight; Choline; Deficiency Diseases; Dietary Proteins; Liver Cirrhosis; Live

1969

Trials

8 trials available for choline and Liver Cirrhosis

ArticleYear
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
    Neuroradiology, 2014, Volume: 56, Issue:10

    Topics: Adolescent; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; H

2014
1H Magnetic Resonance Spectroscopy Predicts Hepatocellular Carcinoma in a Subset of Patients With Liver Cirrhosis: A Randomized Trial.
    Medicine, 2015, Volume: 94, Issue:27

    Topics: Adult; Carcinoma, Hepatocellular; Choline; Hepatitis B, Chronic; Humans; Lipids; Liver Cirrhosis; Li

2015
Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:11

    Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Differentiation; Choline; Chronic Disease; Fem

2010
Brain magnetic resonance spectroscopy in episodic hepatic encephalopathy.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:2

    Topics: Aged; Brain; Brain Chemistry; Brain Edema; Choline; Female; Follow-Up Studies; Glutamic Acid; Hepati

2013
Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:3

    Topics: Adult; Aged; Amino Acids; Ammonia; Basal Ganglia; Brain Chemistry; Choline; Creatinine; Female; Glut

2004
Evaluation of the severity of chronic hepatitis C with 3-T1H-MR spectroscopy.
    AJR. American journal of roentgenology, 2008, Volume: 190, Issue:5

    Topics: Adult; Aged; Choline; Fatty Liver; Female; Glutamic Acid; Glutamine; Hepatitis C, Chronic; Humans; L

2008
Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.
    Radiology, 1994, Volume: 193, Issue:2

    Topics: Adult; Brain Chemistry; Choline; Double-Blind Method; Female; Glutamine; Hepatic Encephalopathy; Hum

1994

Other Studies

134 other studies available for choline and Liver Cirrhosis

ArticleYear
Trans-anethole attenuates diet-induced nonalcoholic steatohepatitis through suppressing TGF-β-mediated fibrosis.
    Clinics and research in hepatology and gastroenterology, 2022, Volume: 46, Issue:4

    Topics: Allylbenzene Derivatives; Animals; Anisoles; Choline; Diet; Liver; Liver Cirrhosis; Methionine; Mice

2022
Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.
    Journal of hepatology, 2022, Volume: 77, Issue:1

    Topics: Animals; Carnitine O-Palmitoyltransferase; Choline; Fatty Acids; Fibrosis; Hepatic Stellate Cells; H

2022
Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet.
    Digestive diseases and sciences, 2023, Volume: 68, Issue:1

    Topics: Animals; Choline; Diet; Diet, High-Fat; Down-Regulation; Estrogens; Female; Fibrosis; Humans; Liver;

2023
Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism.
    The Journal of nutritional biochemistry, 2022, Volume: 106

    Topics: Animals; Chlorogenic Acid; Choline; Choline Deficiency; Diet; Endothelial Cells; HMGB1 Protein; Live

2022
Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2022, Volume: 54, Issue:10

    Topics: Acetamides; Amino Acids; Animals; Caco-2 Cells; Chloride Channels; Choline; Diet; Humans; Lipopolysa

2022
Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis.
    Cellular and molecular gastroenterology and hepatology, 2022, Volume: 14, Issue:4

    Topics: Adenosine; Amino Acids; Animals; Caspases; Choline; Hepatitis; Humans; Inflammasomes; Inflammation;

2022
Loss of YB-1 alleviates liver fibrosis by suppressing epithelial-mesenchymal transition in hepatic progenitor cells.
    Biochimica et biophysica acta. Molecular basis of disease, 2022, 11-01, Volume: 1868, Issue:11

    Topics: Animals; Cadherins; Choline; Collagen; Eosine Yellowish-(YS); Epithelial-Mesenchymal Transition; Eth

2022
IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Disease Models, Animal; Hepatitis; Inflamm

2022
Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation.
    Nutrients, 2022, Sep-15, Volume: 14, Issue:18

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases;

2022
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
    Journal of molecular endocrinology, 2023, Jan-01, Volume: 70, Issue:1

    Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis

2023
Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor.
    Nutrients, 2022, Dec-30, Volume: 15, Issue:1

    Topics: Animals; Body Weight; Choline; Choline Deficiency; Diet; Fibrosis; Humans; Inflammation; Liver; Live

2022
Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast.
    International journal of molecular sciences, 2023, Jan-07, Volume: 24, Issue:2

    Topics: Animals; Antigens; Cell Differentiation; Choline; Disease Models, Animal; Humans; Liver; Liver Cirrh

2023
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
    Journal of nanobiotechnology, 2023, Jan-25, Volume: 21, Issue:1

    Topics: Animals; Choline; Exosomes; Humans; Liver Cirrhosis; Mesenchymal Stem Cells; Mice; Phosphatidylinosi

2023
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla

2023
Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota.
    Scientific reports, 2023, 03-09, Volume: 13, Issue:1

    Topics: alpha-Defensins; Amino Acids; Animals; Choline; Diet, High-Fat; Dysbiosis; Gastrointestinal Microbio

2023
Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE.
    Hepatology communications, 2023, 04-01, Volume: 7, Issue:4

    Topics: Blood-Brain Barrier; Brain; Choline; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirr

2023
Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis.
    Molecular cancer research : MCR, 2023, 09-01, Volume: 21, Issue:9

    Topics: Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Female; Incidence; Inflammation; Liver;

2023
Qing-Zhi-Tiao-Gan-Tang (QZTGT) prevents nonalcoholic steatohepatitis (NASH) by expression pattern correction.
    Journal of ethnopharmacology, 2023, Dec-05, Volume: 317

    Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; No

2023
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
    The Journal of pharmacology and experimental therapeutics, 2023, Volume: 386, Issue:2

    Topics: Animals; Caspase 1; Choline; Inflammasomes; Inflammation; Interleukin-1beta; Liver Cirrhosis; Mice;

2023
iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice.
    Scientific reports, 2023, 07-13, Volume: 13, Issue:1

    Topics: Animals; Choline; Disease Models, Animal; Inflammation; Isotope Labeling; Liver; Liver Cirrhosis; Me

2023
Association of Differentially Altered Liver Fibrosis with Deposition of TGFBi in Stabilin-Deficient Mice.
    International journal of molecular sciences, 2023, Jun-30, Volume: 24, Issue:13

    Topics: Animals; Cell Adhesion Molecules, Neuronal; Choline; Endothelial Cells; Ligands; Liver; Liver Cirrho

2023
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline D

2023
CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response.
    Biochimica et biophysica acta. Molecular basis of disease, 2024, Volume: 1870, Issue:1

    Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Liver Cirrhosis; Methionine; Mice; Non-alc

2024
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice.
    Biology of sex differences, 2023, Nov-14, Volume: 14, Issue:1

    Topics: Animals; Choline; Diet, High-Fat; Fatty Liver; Female; Fibrosis; Humans; Inflammation; Liver Cirrhos

2023
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
    Biomedical research (Tokyo, Japan), 2020, Volume: 41, Issue:1

    Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate C

2020
Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice.
    Biochemical and biophysical research communications, 2020, 07-23, Volume: 528, Issue:2

    Topics: Alanine Transaminase; Amino Acids; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; B

2020
Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet.
    Biochemical and biophysical research communications, 2020, 12-17, Volume: 533, Issue:4

    Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Choline; Diet, High-Fat; Fatty Liver;

2020
[¹¹C] choline as a potential PET/CT biomarker of liver cirrhosis: A prospective pilot study.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2021, Volume: 53, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbon Radioisotopes; Case-Control Studies; Choline; Fem

2021
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
    Lipids in health and disease, 2020, Dec-09, Volume: 19, Issue:1

    Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def

2020
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.
    FEBS open bio, 2021, Volume: 11, Issue:11

    Topics: Amino Acids; Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Lipid Met

2021
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019, Volume: 23, Issue:1

    Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-

2019
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.
    Science translational medicine, 2018, 11-21, Volume: 10, Issue:468

    Topics: Animals; Choline; Diet; Female; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Male;

2018
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
    International journal of molecular sciences, 2019, Jan-14, Volume: 20, Issue:2

    Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Micro

2019
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.
    Toxicology and applied pharmacology, 2013, May-01, Volume: 268, Issue:3

    Topics: Amino Acids; Animals; Choline; Choline Deficiency; Dietary Supplements; Fatty Liver; Iron; Liver Cir

2013
Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:6

    Topics: Animals; Antigens, Ly; Apoptosis; Caspase 3; Choline; Collagen; Dose-Response Relationship, Drug; Fa

2014
Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Amino Acids; Animals; Choline; Diet, High-Fat; Disease Resistance; Female; Gene Deletion; Liver Cirr

2014
Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis.
    Archives of biochemistry and biophysics, 2014, Volume: 555-556

    Topics: Animals; Choline; Diet; Fatty Liver; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice, Inb

2014
Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2015, Volume: 35, Issue:6

    Topics: Animals; Cell Cycle; Choline; Choline Deficiency; Disease Models, Animal; Disease Progression; Food,

2015
Dietary Supplementation of Genistein Alleviates Liver Inflammation and Fibrosis Mediated by a Methionine-Choline-Deficient Diet in db/db Mice.
    Journal of agricultural and food chemistry, 2015, May-06, Volume: 63, Issue:17

    Topics: Animals; Choline; Diet; Dietary Supplements; Disease Models, Animal; Genistein; Humans; Liver; Liver

2015
Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells.
    BMC gastroenterology, 2015, Feb-15, Volume: 15

    Topics: Actins; Animals; Choline; Collagen Type I; Culture Media, Conditioned; Diet; Fatty Acids, Monounsatu

2015
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver

2015
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Choline; Diet; Disease Models, Animal; F

2015
Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver

2015
TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice.
    Molecular medicine reports, 2016, Volume: 13, Issue:3

    Topics: Animals; Chemokines; Choline; Diet; Down-Regulation; Fibrosis; Inflammation; Liver; Liver Cirrhosis;

2016
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression.
    Nature communications, 2016, Mar-22, Volume: 7

    Topics: Animals; Base Sequence; Carbon Tetrachloride; Carcinoma, Hepatocellular; Choline; Chronic Disease; D

2016
MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease.
    Toxicology letters, 2016, Sep-06, Volume: 258

    Topics: Animals; Biomarkers; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal;

2016
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
    Gastroenterology, 2017, Volume: 152, Issue:6

    Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H

2017
A compromised liver alters polychlorinated biphenyl-mediated toxicity.
    Toxicology, 2017, 04-01, Volume: 380

    Topics: Adipokines; Animals; Aroclors; Biomarkers; Blood Glucose; Cardiovascular Diseases; Choline; Diet; Di

2017
The effect of choline, methionine, and low fat diet on the life expectancy of patients with cirrhosis of the liver.
    The Journal of laboratory and clinical medicine, 1948, Volume: 33, Issue:9

    Topics: Choline; Diet, Fat-Restricted; Life Expectancy; Liver Cirrhosis; Methionine

1948
Choline prevents fatty change and cirrhosis in the livers of dogs subjected to hypophysectomy and thyroidectomy.
    Endocrinology, 1948, Volume: 42, Issue:3

    Topics: Animals; Choline; Dogs; Fats; Hypophysectomy; Liver; Liver Cirrhosis; Pituitary Gland; Thyroid Gland

1948
Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.
    International journal of molecular medicine, 2009, Volume: 24, Issue:2

    Topics: Animals; Antioxidants; Choline; Cytokines; Diet; Gene Expression; Glutathione; Hepatic Stellate Cell

2009
Curcumin limits the fibrogenic evolution of experimental steatohepatitis.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:1

    Topics: Actins; Alanine Transaminase; Animals; CD11b Antigen; Cells, Cultured; Chemokine CCL2; Choline; Chol

2010
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:2

    Topics: Animals; Choline; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Inflammation; Liver Ci

2010
[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010, Volume: 18, Issue:2

    Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Choline; Choline Deficiency; Diet; Disease Models,

2010
Use of choline chloride in cirrhosis of the liver, with recovery after 106 paracenteses.
    Rhode Island medical journal, 1947, Volume: 30, Issue:10

    Topics: Choline; Humans; Liver Cirrhosis; Paracentesis

1947
The effect of choline, methionine, and low fat diet on the life expectancy of patients with cirrhosis of the liver.
    Proceedings [of the] annual meeting. Central Society for Clinical Research (U.S.), 1947, Volume: 20

    Topics: Choline; Diet, Fat-Restricted; Life Expectancy; Liver Cirrhosis; Methionine

1947
Choline; an effective treatment in cirrhosis.
    Hospital topics, 1947, Volume: 25, Issue:2

    Topics: Choline; Liver Cirrhosis; Treatment Outcome

1947
The action of choline on the blood lipid fractions in cirrhosis of the liver, diabetes mellitus and related conditions of disturbed fat metabolism.
    Journal. Iowa State Medical Society, 1947, Volume: 37, Issue:4

    Topics: Blood; Choline; Diabetes Mellitus; Fats; Humans; Lipid Metabolism; Lipids; Liver Cirrhosis

1947
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:3

    Topics: Adenoviridae; Anilides; Animals; beta-Galactosidase; Choline; Diet; Fatty Liver; Genetic Vectors; In

2011
The treatment of cirrhosis of the liver with choline and cystine.
    Journal of the American Medical Association, 1946, Jan-26, Volume: 130

    Topics: Choline; Cystine; Humans; Liver Cirrhosis

1946
The significance of fatty infiltration in the development of hepatic cirrhosis due to choline deficiency.
    The Journal of nutrition, 1946, Volume: 31, Issue:2

    Topics: Choline; Choline Deficiency; Liver Cirrhosis

1946
Transforming growth factor-α attenuates hepatic fibrosis: possible involvement of matrix metalloproteinase-1.
    Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:4

    Topics: Animals; Blotting, Western; Cells, Cultured; Choline; Diet; DNA Primers; Enzyme-Linked Immunosorbent

2011
Hepatic injury due to combined choline-deprivation and thioacetamide administration: an experimental approach to liver diseases.
    Digestive diseases and sciences, 2012, Volume: 57, Issue:12

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury;

2012
Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
    Journal of hepatology, 2003, Volume: 38, Issue:6

    Topics: Amino Acids; Animals; Biomarkers; Cell Line; Choline; Collagen Type III; Culture Media; Diet; Dose-R

2003
Choline in nutrition and therapy.
    The Antiseptic, 1952, Volume: 49, Issue:10

    Topics: Choline; Humans; Liver Cirrhosis; Nutritional Status; Organic Chemicals

1952
LIPOTROPIC supplements in fatty cirrhosis.
    Treatment services bulletin. Canada. Department of Veterans' Affairs, 1953, Volume: 8, Issue:1

    Topics: Alcoholism; Choline; Dietary Supplements; Humans; Lipotropic Agents; Liver Cirrhosis; Liver Diseases

1953
Studies on lipotropic factors. I. Choline content of the serum in normal and in patients suffering from cirrhosis of the liver.
    The Indian journal of medical research, 1952, Volume: 40, Issue:4

    Topics: Blood; Choline; Humans; Lipotropic Agents; Liver Cirrhosis

1952
Relative effects of protein and lipotropic substances in the treatment of nutritional cirrhosis in rats.
    Annals of the New York Academy of Sciences, 1954, May-10, Volume: 57, Issue:6

    Topics: Animals; Choline; Diet; Lipotropic Agents; Liver Cirrhosis; Liver Cirrhosis, Experimental; Methionin

1954
Nutritional aspects of cirrhosis in alcoholism; effect of a purified diet supplemented with choline.
    Annals of the New York Academy of Sciences, 1954, May-10, Volume: 57, Issue:6

    Topics: Alcoholism; Choline; Diet; Dietary Supplements; Humans; Liver Cirrhosis

1954
Clinical and nutritional aspects of lipotropic agents; with special reference to their role in the pathogenesis and treatment of fatty cirrhosis of the liver.
    Journal of the American Medical Association, 1956, Mar-17, Volume: 160, Issue:11

    Topics: Choline; Humans; Lipotropic Agents; Liver Cirrhosis; Liver Diseases; Methionine

1956
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
    Archivos de medicina experimental; trabajos del Instituto Nacional de Ciencias Medicas, 1955, Volume: 18, Issue:4

    Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans;

1955
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
    Archivos de medicina experimental; trabajos del Instituto Nacional de Ciencias Medicas, 1955, Volume: 18, Issue:4

    Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans;

1955
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
    Archivos de medicina experimental; trabajos del Instituto Nacional de Ciencias Medicas, 1955, Volume: 18, Issue:4

    Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans;

1955
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
    Archivos de medicina experimental; trabajos del Instituto Nacional de Ciencias Medicas, 1955, Volume: 18, Issue:4

    Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans;

1955
[Experimental data on production of liver cirrhosis induced by dietary choline and methionine deficiencies].
    Biulleten' eksperimental'noi biologii i meditsiny, 1957, Volume: 44, Issue:12

    Topics: Animals; Choline; Choline Deficiency; Diet; Liver Cirrhosis; Liver Cirrhosis, Experimental; Methioni

1957
[Effect of some vitamins from the B group (B12 and choline) on the cholesterol-esterifying function of the liver in liver cirrhosis].
    Trudy Leningradskogo sanitarno-gigienicheskogo meditsinskogo instituta, 1961, Volume: 69

    Topics: Cholesterol; Choline; Lipid Metabolism; Liver Cirrhosis; Vitamin A; Vitamin B 12; Vitamins

1961
Treatment of nutritional cirrhosis in rats with choline and methionine; with special reference to fibrogenesis and fibroclasia.
    The Anatomical record, 1963, Volume: 145

    Topics: Animals; Choline; Liver Cirrhosis; Methionine; Rats

1963
Fatty cirrhosis in the rat. V. Regression upon return to normal diet.
    The American journal of pathology, 1963, Volume: 42

    Topics: Animals; Choline; Diet; Fatty Liver; Fibrosis; Liver Cirrhosis; Liver Cirrhosis, Experimental; Rats

1963
[THE EFFECT OF CHOLINE PHOSPHOLIPIDS ON THE SPECTRUM OF FREE PLASMA AMINO ACIDS IN TOXIC LIVER DAMAGE].
    Klinische Wochenschrift, 1963, Sep-15, Volume: 41

    Topics: Amino Acids; Blood; Chemical and Drug Induced Liver Injury; Choline; Glycine max; Hepatitis; Linolei

1963
SERUM PROTEINS IN FATTY CIRRHOSIS OF THE RAT.
    Archives of pathology, 1964, Volume: 77

    Topics: Blood Protein Electrophoresis; Choline; Deficiency Diseases; Fatty Liver; gamma-Globulins; Liver Cir

1964
[THE ASSOCIATION OF SORBITOL, GLUTAMIC ACID AND CHOLINE HYPOSULFITE IN THE THERAPY OF HEPATIC DISEASES AND MINOR HEPATIC INSUFFICIENCY].
    Gazzetta medica italiana, 1963, Volume: 122

    Topics: Adolescent; Biliary Dyskinesia; Child; Cholangitis; Cholecystitis; Cholelithiasis; Choline; Dithioni

1963
FATTY CIRRHOSIS IN THE RAT. VI. PATTERN OF FAT RE-ACCUMULATION AFTER RE-INSTITUTION OF CHOLINE DEFICIENCY.
    The American journal of pathology, 1963, Volume: 43

    Topics: Choline; Choline Deficiency; Fatty Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Dise

1963
ALTERATIONS IN CHOLINE-DEFICIENT CIRRHOSIS. A HISTOCHEMICAL STUDY.
    Archives of pathology, 1964, Volume: 77

    Topics: Choline; Deficiency Diseases; Dihydrolipoamide Dehydrogenase; Electron Transport Complex II; Fatty L

1964
[ALKALINE PHOSPHATASE AND MUCOPOLYSACCHARIDES IN GRANULOCYTES UNDER THE INFLUENCE OF LEVULOSE AND CHOLINE INFUSIONS].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1963, Volume: 23

    Topics: Acetylcholine; Alkaline Phosphatase; Choline; Fructose; Glycosaminoglycans; Granulocytes; Hepatitis;

1963
INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT.
    The Journal of experimental medicine, 1964, Apr-01, Volume: 119

    Topics: Animals; Body Weight; Choline; Choline Deficiency; Endotoxins; Liver Cirrhosis; Liver Cirrhosis, Exp

1964
METABOLISM OF SERUM ALBUMIN IN RATS WITH CIRRHOSIS OF THE LIVER.
    The Journal of laboratory and clinical medicine, 1964, Volume: 63

    Topics: Choline; Cystine; Dietary Fats; Liver Cirrhosis; Methionine; Proteins; Rats; Research; Serum Albumin

1964
RENAL TUBULAR CALCIFICATION IN RATS IN CHRONIC CHOLINE DEFICIENCY.
    The Indian journal of medical research, 1964, Volume: 52

    Topics: Calcification, Physiologic; Choline; Choline Deficiency; Deficiency Diseases; Dietary Fats; Fatty Ac

1964
[EXPERIMENTAL LIVER CIRRHOSIS. 1. MORPHOLOGIC AND BIOCHEMICAL STUDY OF THE LIVER IN RATS FED ON DIETS DEFICIENT IN CHOLINE].
    Biologica (Santiago, Chile), 1963, Volume: 35

    Topics: Animals; Biochemical Phenomena; Biochemistry; Choline; Deficiency Diseases; Diet; Hydroxyproline; Li

1963
PROLIFERATION OF BILE DUCTS IN CIRRHOSIS.
    Archives of pathology, 1964, Volume: 78

    Topics: Bile Ducts; Carbon Tetrachloride Poisoning; Choline; Ethionine; Liver Cirrhosis; Liver Cirrhosis, Ex

1964
EXPERIMENTAL HEMOCHROMATOSIS IN RATS.
    The American journal of pathology, 1965, Volume: 46

    Topics: Choline; Choline Deficiency; Coloring Agents; Diet; Dietary Fats; Hemochromatosis; Histocytochemistr

1965
THE SERUM AND LIVER AMYLASE AND TRANSAMINASE ACTIVITIES IN CHOLINE DEFICIENCY FATTY LIVER AND CIRRHOSIS.
    Gastroenterology, 1965, Volume: 48

    Topics: Alanine Transaminase; Amylases; Choline; Choline Deficiency; Clinical Enzyme Tests; Dietary Proteins

1965
LOW PROTEIN DIET AS A FACTOR IN THE PRODUCTION OF EXPERIMENTAL SCHISTOSOMAL HEPATIC FIBROSIS.
    The Journal of pathology and bacteriology, 1965, Volume: 89

    Topics: Animals; Caseins; Choline; Cysts; Diet; Diet, Protein-Restricted; Dietary Proteins; Granuloma; Liver

1965
FATTY CIRRHOSIS IN THE RAT. VII. INFLUENCE OF DIFFERENT LEVELS OF DIETARY FAT ON EARLY DEPOSITION OF FAT IN LIVER.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 118

    Topics: Choline; Choline Deficiency; Deficiency Diseases; Dietary Fats; Fatty Liver; Liver Cirrhosis; Pathol

1965
NUTRITIONAL LAENNEC'S CIRRHOSIS IN THE MACACA MULATTA MONKEY.
    The Journal of surgical research, 1965, Volume: 5

    Topics: Animals; Blood Chemical Analysis; Body Weight; Choline; Choline Deficiency; Dietary Fats; Dietary Pr

1965
EFFECTS OF UNSATURATED FATS ON DIETARY-INDUCED CIRRHOSIS IN THE RAT.
    Archives of pathology, 1965, Volume: 79

    Topics: Biochemical Phenomena; Biochemistry; Cholesterol; Choline; Choline Deficiency; Dietary Fats; Fats, U

1965
REVERSIBLE AND IRREVERSIBLE CHANGES IN EXPERIMENTAL CIRRHOSIS.
    The American journal of pathology, 1965, Volume: 47

    Topics: Amides; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Choline; Choline Def

1965
Experimental pigment cirrhosis: its production in rats by feeding a choline-deficient diet with excess iron.
    The American journal of pathology, 1960, Volume: 36

    Topics: Animals; Choline; Diet; Hemochromatosis; Iron; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver

1960
Pathogenesis of nutritional cirrhosis.
    Archives of internal medicine, 1962, Volume: 110

    Topics: Animals; Choline; Choline Deficiency; Liver Cirrhosis; Liver Cirrhosis, Experimental

1962
[Changes in the blood alkaline phosphatase level under the influence of vitamin B12 and choline in liver cirrhosis].
    Trudy Leningradskogo sanitarno-gigienicheskogo meditsinskogo instituta, 1961, Volume: 69

    Topics: Alkaline Phosphatase; Choline; Corrinoids; Hematinics; Humans; Leadership; Liver Cirrhosis; Phosphor

1961
Effect of antibiotics, sulfonamides, and a nitrofuran on development of hepatic cirrhosis in choline-deficient rats.
    The Journal of nutrition, 1962, Volume: 76

    Topics: Animals; Anti-Bacterial Agents; Choline; Choline Deficiency; Liver Cirrhosis; Liver Cirrhosis, Exper

1962
Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.
    Journal of hepatology, 2003, Volume: 39, Issue:5

    Topics: Animals; Choline; Diet; Fatty Liver; Gene Expression; Hepatocytes; Lipid Peroxidation; Liver; Liver

2003
Osteoactivin expressed during cirrhosis development in rats fed a choline-deficient, L-amino acid-defined diet, accelerates motility of hepatoma cells.
    Journal of hepatology, 2003, Volume: 39, Issue:5

    Topics: Aged; Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Movement; Choline; Clonin

2003
Choline excretion in patients with and without diseases of the liver and in carcinoma of the gastro-intestinal tract.
    Experimental medicine and surgery, 1951, Volume: 9, Issue:1

    Topics: Carcinoma; Choline; Digestive System; Gastrointestinal Tract; Humans; Liver Cirrhosis

1951
[Recent data on the literature and personal research of choline metabolism].
    Revue medicale de Liege, 1951, Feb-01, Volume: 6, Issue:3

    Topics: Choline; Humans; Liver Cirrhosis; Publications; Research

1951
[On choline therapy].
    Therapie der Gegenwart, 1952, Volume: 91, Issue:4

    Topics: Choline; Hepatitis; Hepatitis A; Humans; Liver Cirrhosis; Viral Vaccines

1952
The relative effects of protein, choline, and methionine in the treatment of experimental dietary cirrhosis in the rat.
    The Journal of experimental medicine, 1952, Volume: 96, Issue:3

    Topics: Animals; Choline; Dietary Supplements; Liver Cirrhosis; Liver Cirrhosis, Experimental; Methionine; R

1952
Phospholipid synthesis in patients with cirrhosis and infectious hepatitis; the effects of choline and methionine as measured by radioactive phosphorus.
    Southern medical journal, 1950, Volume: 43, Issue:3

    Topics: Choline; Communicable Diseases; Hepatitis; Hepatitis A; Liver; Liver Cirrhosis; Methionine; Phosphor

1950
The effects of lipotropic factors on phospholipide turnover in the plasma of patients with cirrhosis of the liver, as indicated by radioactive phosphorus.
    The Journal of clinical investigation, 1950, Volume: 29, Issue:5

    Topics: Blood; Choline; Lipotropic Agents; Liver; Liver Cirrhosis; Phospholipids; Phosphorus; Phosphorus Rad

1950
The importance of methionine and choline in the arrest of dietary cirrhosis of the liver in the rat.
    The American journal of pathology, 1950, Volume: 26, Issue:5

    Topics: Animals; Choline; Diet; Liver; Liver Cirrhosis; Methionine; Rats

1950
[Effect of lipotropic substances upon blood and liver lipoids in experimental fatty liver and in liver cirrhosis in man].
    Klinische Wochenschrift, 1950, Aug-01, Volume: 28, Issue:29-30

    Topics: Choline; Fatty Liver; Lipotropic Agents; Liver; Liver Cirrhosis; Methionine

1950
Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy.
    Neuroradiology, 2005, Volume: 47, Issue:1

    Topics: Aspartic Acid; Cerebral Cortex; Choline; Creatinine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli

2005
[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)].
    Zeitschrift fur Gastroenterologie, 2005, Volume: 43, Issue:4

    Topics: Adult; Ammonia; Brain; Choline; Combined Modality Therapy; Creatinine; Diet, Protein-Restricted; Dip

2005
Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model.
    Biochimica et biophysica acta, 2005, Oct-15, Volume: 1737, Issue:1

    Topics: Animals; Choline; Choline Deficiency; Deuterium; Diet; Disease Models, Animal; Fatty Liver; Lipid Me

2005
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
    Academic radiology, 2006, Volume: 13, Issue:12

    Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models,

2006
Brain abscess in adult cirrhotic patients: two case reports.
    The Kaohsiung journal of medical sciences, 2007, Volume: 23, Issue:1

    Topics: Aged; Aspartic Acid; Brain Abscess; Choline; Creatine; Humans; Liver Cirrhosis; Magnetic Resonance I

2007
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:6

    Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Choline; Cytochrome P-450 CYP2E1; Diacylglycerol O

2007
Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animal Feed; Animals; Choline; Connective Tissue Growth Fac

2007
Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet.
    Journal of gastrointestinal and liver diseases : JGLD, 2008, Volume: 17, Issue:1

    Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Choline;

2008
Cytoprotective effect of 16, 16' dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rat.
    Folia histochemica et cytochemica, 1980, Volume: 18, Issue:4

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Chemical and Drug Induced Liver Injury; Choline; Drug Combi

1980
[Clinical experience report on Hepavis].
    Die Medizinische Welt, 1980, Oct-17, Volume: 31, Issue:42

    Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Choline; Dehydrocholic Acid; Drug Co

1980
Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging.
    Hepatology (Baltimore, Md.), 1997, Volume: 25, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Hepatic Encephalopathy; Humans; I

1997
Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Energy Metabolism; Female; Gl

1999
Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy.
    Liver, 1999, Volume: 19, Issue:5

    Topics: Adult; Aged; Brain; Choline; Creatinine; Electroencephalography; Female; Glutamic Acid; Glutamine; H

1999
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
    Journal of hepatology, 2002, Volume: 37, Issue:1

    Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D

2002
Trimethylamine metabolism in liver disease.
    Lancet (London, England), 1978, May-20, Volume: 1, Issue:8073

    Topics: Choline; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methylamines

1978
Choline may be an essential nutrient in malnourished patients with cirrhosis.
    Gastroenterology, 1989, Volume: 97, Issue:6

    Topics: Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Choline; Choline Deficien

1989
Plasma concentrations of transsulfuration pathway products during nasoenteral and intravenous hyperalimentation of malnourished patients.
    The American journal of clinical nutrition, 1985, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Amino Acids; Blood Proteins; Carnitine; Choline; Creatine; Cysteine; Entera

1985
Lipotropic products.
    The Medical letter on drugs and therapeutics, 1973, Jul-20, Volume: 15, Issue:15

    Topics: Choline; Humans; Inositol; Lipotropic Agents; Liver Cirrhosis

1973
[Therapeutic progress in chronic liver diseases].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1968, Volume: 28, Issue:2

    Topics: Choline; Chronic Disease; Folic Acid; Hepatitis; Humans; Liver Cirrhosis; Orotic Acid; Thioctic Acid

1968
[Dietetic therapy of liver diseases].
    Minerva medica, 1972, Jun-27, Volume: 63, Issue:49

    Topics: Choline; Chronic Disease; Diet Therapy; Dietary Proteins; Fatty Acids; Fatty Liver; Hepatic Encephal

1972
Effect of a high-ethanol and choline-deficient diet on the metabolism of ( 3 H)oestradiol in vitro by subcellular fractions of male rat livers.
    The Biochemical journal, 1971, Volume: 123, Issue:4

    Topics: Animals; Biopsy; Cell Fractionation; Centrifugation; Choline; Diet; Estradiol; Ethanol; In Vitro Tec

1971
A comparison of chronic alcohol ingestion in male rats fed normal and cirrhogenic diets.
    The West Virginia medical journal, 1968, Volume: 64, Issue:10

    Topics: Animals; Choline; Diet; Ethanol; Liver Cirrhosis; Male; Rats

1968
[Fibrosis and cirrhosis in the rat liver after the replacement of a proteinand choline-deficient diet with a complete one].
    Arkhiv patologii, 1969, Volume: 31, Issue:3

    Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Proteins; Fatty Liver; Liver Cirrhosis; Methods;

1969
[Evolution of chronic diffuse liver diseases treated by essential choline phospholipid therapy. Clinical and analytical control through exploration with radioactive isotopes].
    Revista espanola de las enfermedades del aparato digestivo, 1967, Volume: 26, Issue:4

    Topics: Adult; Choline; Female; Gold Isotopes; Hepatitis; Humans; Iodine Radioisotopes; Liver Cirrhosis; Liv

1967
Fatty cirrhosis in the rat.
    Archives of pathology, 1966, Volume: 81, Issue:6

    Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats;

1966
Renal changes in dietary hepatic injury in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1966, Volume: 123, Issue:3

    Topics: Animals; Choline; Diet; Kidney Tubules; Liver Cirrhosis; Methionine; Rats; Vitamin B 12

1966
[Effect of choline chloride on the oxygen content of arterial blood in liver diseases].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1966, Volume: 26, Issue:2

    Topics: Arteries; Choline; Fructose; Hepatitis A; Humans; Hypertension, Portal; Infusions, Parenteral; Liver

1966