choline has been researched along with Leukodystrophy, Metachromatic in 3 studies
Leukodystrophy, Metachromatic: An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Late infantile metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder that causes severe demyelination of the nervous system." | 2.75 | Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. ( Barton, NW; Fogh, J; Hanson, LG; i Dali, C; Lund, AM; Nair, N, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Feldmann, J | 1 |
| Martin, P | 1 |
| Bender, B | 1 |
| Laugwitz, L | 1 |
| Zizmare, L | 1 |
| Trautwein, C | 1 |
| Krägeloh-Mann, I | 1 |
| Klose, U | 1 |
| Groeschel, S | 1 |
| i Dali, C | 1 |
| Hanson, LG | 1 |
| Barton, NW | 1 |
| Fogh, J | 1 |
| Nair, N | 1 |
| Lund, AM | 1 |
| Kruse, B | 1 |
| Hanefeld, F | 1 |
| Christen, HJ | 1 |
| Bruhn, H | 1 |
| Michaelis, T | 1 |
| Hänicke, W | 1 |
| Frahm, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/II, Open Labeled, Monocentric Study of Direct Intracranial Administration of a Replication Deficient Adeno-associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human ARSA cDNA to Children With Metachromatic Leukodystrophy.[NCT01801709] | Phase 1/Phase 2 | 5 participants (Anticipated) | Interventional | 2014-06-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for choline and Leukodystrophy, Metachromatic
| Article | Year |
|---|---|
Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy.
Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Choline; Cognition; Creatine; Disease Progressio | 2010 |
2 other studies available for choline and Leukodystrophy, Metachromatic
| Article | Year |
|---|---|
MR-spectroscopy in metachromatic leukodystrophy: A model free approach and clinical correlation.
Topics: Aspartic Acid; Brain; Choline; Creatine; Glutamine; Humans; Inositol; Leukodystrophy, Metachromatic; | 2023 |
Alterations of brain metabolites in metachromatic leukodystrophy as detected by localized proton magnetic resonance spectroscopy in vivo.
Topics: Adolescent; Aspartic Acid; Bone Marrow Transplantation; Brain; Brain Chemistry; Child; Child, Presch | 1993 |