Compounds > choline
Page last updated: 2024-10-17

choline and Innate Inflammatory Response

choline has been researched along with Innate Inflammatory Response in 164 studies

Research Excerpts

ExcerptRelevanceReference
"Choline supplementation improved growth performance and prevented gut inflammation in weaned piglets by altering gut microbiota and lipid metabolism."9.41Supplemental Choline Modulates Growth Performance and Gut Inflammation by Altering the Gut Microbiota and Lipid Metabolism in Weaned Piglets. ( Gao, K; Hou, L; Jiang, Z; Li, K; Liu, S; Qiu, Y; Wang, L; Yang, X, 2021)
"Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment."8.31Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring. ( Hurley, L; Ille, S; Jadavji, NM; Jauhal, J; Malysheva, OV; Pull, K, 2023)
" In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver."8.31Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023)
" We aimed to evaluate whether residual risk of recurrent stroke of TMAO and its precursor choline remain among patients who received dual-antiplatelet therapy and intensive lipid-lowering therapy and with a low inflammation level (high-sensitivity C-reactive protein <2 mg/L on admission)."8.12Residual Risk of Trimethylamine-N-Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy. ( Cheng, A; Jiang, X; Jin, A; Li, H; Li, K; Lin, J; Meng, X; Wang, Y; Xu, J; Xue, J; Zhao, M; Zheng, L, 2022)
"Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite after ingesting dietary choline, has been identified as a novel risk factor for atherosclerosis through inducing vascular inflammation."8.12Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1. ( Hong, Y; Ji, N; Luo, X; Ma, W; Nie, Z; Shan, J; Xue, J; Zhang, T; Zhang, Y; Zhou, S; Zhu, W, 2022)
" The aim of this cross-sectional study was to explore whole-blood FA, serum lipid composition, and carnitine- and choline derivatives in 78 RA outpatients with different degrees of periodontal inflammation."8.02Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation. ( Berge, RK; Beyer, K; Bjørndal, B; Bolstad, AI; Brun, JG; Lie, SA; Svardal, A, 2021)
"A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling."7.96High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. ( Li, X; Li, Y; Shuai, W; Wang, D; Wen, J; Xiang, J, 2020)
"Lipopolysaccharide significantly increased SBP and urinary albumin and decreased pregnancy outcomes, and these effects were partially reversed by higher choline treatment."7.88Choline Supplementation During Pregnancy Protects Against Gestational Lipopolysaccharide-Induced Inflammatory Responses. ( Bao, J; Garfield, RE; Han, X; Liu, H; Shi, SQ; Yang, J; Zhang, M, 2018)
"To assess the effect of choline in ameliorating lipopolysaccharide (LPS)-induced central nervous system inflammation and cognitive deficits in mice and explore the underlying mechanism."7.85[Choline improves lipopolysaccharide-induced central nervous system inflammatory response and cognitive dysfunction in mice]. ( DU, CY; Feng, ZG; Jin, SY; Wang, H; Yu, J; Zhang, N; Zhang, WD; Zhao, WX, 2017)
"In CF patients, hepatic and plasma homeostasis of choline and PC correlate with lung function and inflammation."7.81Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation. ( Bernhard, W; Grothe, J; Pynn, CJ; Raith, M; Riethmüller, J; Stoll, D; Tschürtz, SM, 2015)
") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain."7.77The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011)
" Here, the anti-inflammatory activity of choline was investigated in a mouse model of allergic airway inflammation."7.74Effect of choline chloride in allergen-induced mouse model of airway inflammation. ( Arora, N; Gaur, SN; Mehta, AK; Singh, BP, 2007)
"18F-choline uptake by inflammation was lower than that of 2DG in the tissue distribution study, and 18F-choline uptake by abscess wall was significantly lower than that of 2DG in the autoradiography study."7.73Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation. ( Fukuda, H; Furumoto, S; Ishiwata, K; Iwata, R; Kawamura, K; Kubota, K, 2006)
"Ibudilast-treated participants had lower Cho in superior frontal white matter and nominally lower MI in pregenual anterior cingulate cortex."7.11Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. ( Alger, J; Burnette, E; Evans, CJ; Grodin, EN; Irwin, MR; London, ED; Meredith, LR; Miotto, K; Nieto, SJ; O'Neill, J; Ray, LA, 2022)
"Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver diseases characterized by steatosis, inflammation, and fibrosis."5.72Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. ( Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N, 2022)
"Melatonin was administered at 20 mg/kg during the last 2 weeks."5.72Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. ( Colares, JR; da Silva, JB; Hartmann, RM; Marroni, CA; Marroni, NP; Miguel, FM; Picada, JN; Schemitt, EG, 2022)
"Inflammation drives the pathogenesis of nonalcoholic steatohepatitis (NASH)."5.62Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation. ( Alpini, G; Francis, H; Glaser, S; Li, H; Li, Q; Matthews, DR; Wu, C; Zhou, J, 2021)
"Choline is a key nutrient in fetal brain development."5.62Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. ( Balser, M; D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Walker, VK, 2021)
"Choline is a dietary component that is crucial for normal cellular function."5.56Effects of choline supplementation on liver biology, gut microbiota, and inflammation in Helicobacter pylori-infected mice. ( Cao, M; Chen, J; Huang, M; Li, S; Liu, Y; Wu, D; Wu, M; Yan, S; Yu, Z; Zhao, J; Zhou, J, 2020)
"Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH)."5.51Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease. ( Carvajal, S; Casals, E; Casals, G; Fernández-Varo, G; González de la Presa, B; Jiménez, W; Morales-Ruíz, M; Oró, D; Parra, M; Pastor, Ó; Perramón, M; Puntes, V; Ribera, J, 2019)
"Choline is an essential nutrient that is required for synthesis of the main eukaryote phospholipid, phosphatidylcholine."5.48Choline transport links macrophage phospholipid metabolism and inflammation. ( Bennett, SAL; Fullerton, MD; Ghorbani, P; LeBlond, ND; Margison, KD; Nguyen, T; Nunes, JRC; O'Dwyer, C; Snider, SA; Xu, H, 2018)
" Several works reported that the bioavailability of DHA to the brain is higher when DHA is acylated to phospholipid."5.46Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro. ( Bernoud-Hubac, N; Fourrier, C; Greenhalgh, AD; Guichardant, M; Joffre, C; Lagarde, M; Layé, S; Remus-Borel, J, 2017)
"Choline supplementation improved growth performance and prevented gut inflammation in weaned piglets by altering gut microbiota and lipid metabolism."5.41Supplemental Choline Modulates Growth Performance and Gut Inflammation by Altering the Gut Microbiota and Lipid Metabolism in Weaned Piglets. ( Gao, K; Hou, L; Jiang, Z; Li, K; Liu, S; Qiu, Y; Wang, L; Yang, X, 2021)
"Choline was described to potentiate the antinociceptive action of aspirin at small doses in several inflammatory pain models."5.40Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide. ( Pan, ZY; Wang, H, 2014)
"Quercetin (50 mg/kg) was given by oral route daily."5.38Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. ( González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D, 2012)
"Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models."5.37Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011)
"Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks."5.36Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010)
"The treatment with choline showed significant reduction in symptom/drug score and improvement in PC(20) FEV1 compared to baseline or standard pharmacotherapy (p<0."5.36Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma. ( Arora, N; Gaur, SN; Mehta, AK; Singh, BP, 2010)
"When choline (2 mg/kg) was coadministered with aspirin (9."5.33Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005)
"Endotoxemia treatment options are still of interest due to high mortality and choline treatment is one of them because of its role in the cholinergic anti-inflammatory pathway."5.30Serum choline and butyrylcholinesterase changes in response to endotoxin in calves receiving intravenous choline administration. ( Cansev, M; Ceron, JJ; Eralp Inan, O; Kasap, S; Kocaturk, M; Rubio, CP; Tvarijonaviciute, A; Ulus, IH; Yilmaz, Z, 2019)
"Higher maternal choline levels have positive effects on the development of brain function for infants of mothers who experienced viral infections in early pregnancy."5.12Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development. ( Clark, AM; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ, 2021)
"Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy."5.05Choline: An Essential Nutrient for Skeletal Muscle. ( Bertone, M; Iolascon, G; Liguori, S; Moretti, A; Paoletta, M; Toro, G, 2020)
"Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice."4.31Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023)
" In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver."4.31Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023)
"Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment."4.31Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring. ( Hurley, L; Ille, S; Jadavji, NM; Jauhal, J; Malysheva, OV; Pull, K, 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; 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Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
" In the choline-deficient, L-amino acid-defined high-fat diet model of fibrotic NASH, myeloid-specific Nlrp3 knock-out but not hepatocyte- or HSC-specific knock-out mice showed significant reduction in inflammation independent of steatosis development."4.12Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. ( Booshehri, LM; Broderick, L; Feldstein, AE; Friess, H; Hartmann, D; Hoffman, HM; Kaufmann, B; Kim, AD; Kui, L; Leszczynska, A; Reca, A; Wree, A, 2022)
"Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite after ingesting dietary choline, has been identified as a novel risk factor for atherosclerosis through inducing vascular inflammation."4.12Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1. ( Hong, Y; Ji, N; Luo, X; Ma, W; Nie, Z; Shan, J; Xue, J; Zhang, T; Zhang, Y; Zhou, S; Zhu, W, 2022)
" Therefore, PSRC1 overexpression and reduced choline consumption may further alleviate atherosclerosis."4.12Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE ( Chen, M; Chen, P; Guo, Z; Liu, D; Luo, T; Ou, C, 2022)
" We aimed to evaluate whether residual risk of recurrent stroke of TMAO and its precursor choline remain among patients who received dual-antiplatelet therapy and intensive lipid-lowering therapy and with a low inflammation level (high-sensitivity C-reactive protein <2 mg/L on admission)."4.12Residual Risk of Trimethylamine-N-Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy. ( Cheng, A; Jiang, X; Jin, A; Li, H; Li, K; Lin, J; Meng, X; Wang, Y; Xu, J; Xue, J; Zhao, M; Zheng, L, 2022)
"Maternal infection, depression, obesity, and other factors associated with inflammation were assessed at 16 weeks gestation, along with maternal C-reactive protein (CRP), cytokines, and serum choline."4.02Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. ( D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Wyrwa, A, 2021)
" The aim of this cross-sectional study was to explore whole-blood FA, serum lipid composition, and carnitine- and choline derivatives in 78 RA outpatients with different degrees of periodontal inflammation."4.02Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation. ( Berge, RK; Beyer, K; Bjørndal, B; Bolstad, AI; Brun, JG; Lie, SA; Svardal, A, 2021)
"A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling."3.96High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. ( Li, X; Li, Y; Shuai, W; Wang, D; Wen, J; Xiang, J, 2020)
" The methylation of phosphatidylethanolamine to form choline has been extensively studied in the context of fatty liver disease."3.96Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. ( da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE, 2020)
"Lipopolysaccharide significantly increased SBP and urinary albumin and decreased pregnancy outcomes, and these effects were partially reversed by higher choline treatment."3.88Choline Supplementation During Pregnancy Protects Against Gestational Lipopolysaccharide-Induced Inflammatory Responses. ( Bao, J; Garfield, RE; Han, X; Liu, H; Shi, SQ; Yang, J; Zhang, M, 2018)
"To assess the effect of choline in ameliorating lipopolysaccharide (LPS)-induced central nervous system inflammation and cognitive deficits in mice and explore the underlying mechanism."3.85[Choline improves lipopolysaccharide-induced central nervous system inflammatory response and cognitive dysfunction in mice]. ( DU, CY; Feng, ZG; Jin, SY; Wang, H; Yu, J; Zhang, N; Zhang, WD; Zhao, WX, 2017)
" The aim of the present study was to elucidate the role of the TLR4‑dependent signaling pathway, and examine the effect of pioglitazone on hepatic fibrosis, through modulation of the TLR4 pathway in a mouse model of nutritional fibrotic steatohepatitis."3.83TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice. ( Du, J; Kong, L; Nan, Y; Niu, X; Wang, R; Zhang, Y; Zhao, S, 2016)
"In CF patients, hepatic and plasma homeostasis of choline and PC correlate with lung function and inflammation."3.81Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation. ( Bernhard, W; Grothe, J; Pynn, CJ; Raith, M; Riethmüller, J; Stoll, D; Tschürtz, SM, 2015)
"The aim of this study is to evaluate uptake of 2-(18)F-fluoroethyl-bis(zinc(II)-dipicolylamine) ((18)F-FEN-DPAZn2) as a promising cell death imaging agent, a choline analog (18)F-fluoroethylcholine ((18)F-FECH), (18)F-fluoride as a bone imaging agent, and a glucose analog 2-(18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG) in the combined S180 fibrosarcoma and turpentine-induced inflammation mice models."3.80Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation. ( Hu, K; Huang, T; Liang, X; Nie, D; Sun, T; Tang, G; Tang, X; Wang, H, 2014)
"In the MCD mice, aliskiren attenuated hepatic steatosis, inflammation and fibrosis."3.79Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. ( Chan, CC; Hsieh, YC; Huang, YH; Lee, KC; Lin, HC; Yang, YY, 2013)
") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain."3.77The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011)
"The purpose of this study was to explore the feasibility of (11)C-choline in the assessment of the degree of inflammation in atherosclerotic plaques."3.76Uptake of 11C-choline in mouse atherosclerotic plaques. ( Hellberg, S; Knuuti, J; Laine, VJ; Laitinen, IE; Luoto, P; Marjamäki, PM; Någren, K; Roivainen, A; Silvola, JM; Ylä-Herttuala, S, 2010)
" Feeding a diet deficient in both methionine and choline (MCD) is one of the most common models of NASH, which is characterized by steatosis, mitochondrial dysfunction, hepatocellular injury, oxidative stress, inflammation, and fibrosis."3.76Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. ( Caballeria, J; Caballero, F; Elena, M; Fernández, A; Fernández-Checa, JC; Fucho, R; García-Ruiz, C; Martínez, L; Matías, N; Morales, A, 2010)
"The scope of this work was to investigate the associations between dietary choline and betaine consumption and various markers of low-grade systemic inflammation."3.74Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. ( Antonopoulou, S; Detopoulou, P; Panagiotakos, DB; Pitsavos, C; Stefanadis, C, 2008)
" Here, the anti-inflammatory activity of choline was investigated in a mouse model of allergic airway inflammation."3.74Effect of choline chloride in allergen-induced mouse model of airway inflammation. ( Arora, N; Gaur, SN; Mehta, AK; Singh, BP, 2007)
"18F-choline uptake by inflammation was lower than that of 2DG in the tissue distribution study, and 18F-choline uptake by abscess wall was significantly lower than that of 2DG in the autoradiography study."3.73Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation. ( Fukuda, H; Furumoto, S; Ishiwata, K; Iwata, R; Kawamura, K; Kubota, K, 2006)
"Ibudilast-treated participants had lower Cho in superior frontal white matter and nominally lower MI in pregenual anterior cingulate cortex."3.11Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. ( Alger, J; Burnette, E; Evans, CJ; Grodin, EN; Irwin, MR; London, ED; Meredith, LR; Miotto, K; Nieto, SJ; O'Neill, J; Ray, LA, 2022)
"Hypertension is the most prevalent chronic disease and a risk factor for various diseases."2.72TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies. ( Ding, YJ; Jia, QJ; Li, YY; Lv, SC; Wang, YJ; Zhang, A; Zhang, JP; Zhang, WQ; Zhang, XN; Zhu, YP, 2021)
"Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998."2.45Choline: an essential nutrient for public health. ( da Costa, KA; Zeisel, SH, 2009)
"While NKT-cell involvement in steatohepatitis is debated, discrepancies may stem from varied mouse strains used, predominantly C57BL6/J with Th1-dominant responses."1.91Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice. ( Andrés-Sánchez, N; Colell, A; Cuño-Gómiz, C; de Gregorio, E; Marí, M; Morales, A; Rider, P; Tutusaus, A, 2023)
"plantarum against nonalcoholic steatohepatitis (NASH) and its underlying mechanisms remain unelucidated."1.91Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production. ( Gee, HY; Kim, DY; Park, JY, 2023)
"However, the effect of ACT001 on nonalcoholic steatohepatitis (NASH) is unknown."1.91iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice. ( Chen, Z; Chu, W; Li, P; Liu, Y; Mi, Y; Niu, B; Wu, X; Zhou, H; Zhou, Y, 2023)
"Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC."1.91Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis. ( Deepa, SS; Freeman, WM; Georgescu, C; Haritha, NH; Janknecht, R; Luo, W; Miller, BF; Mohammed, S; Nicklas, EH; Oh, S; Ohene-Marfo, P; Thadathil, N; Tran, AL; Van Der Veldt, M; Wang, D; Wren, JD, 2023)
"Autophagy affects NAFLD by improving steatosis."1.72Ubiquitin-specific peptidase 10 ameliorates hepatic steatosis in nonalcoholic steatohepatitis model by restoring autophagic activity. ( Xin, SL; Yu, YY, 2022)
"Melatonin was administered at 20 mg/kg during the last 2 weeks."1.72Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. ( Colares, JR; da Silva, JB; Hartmann, RM; Marroni, CA; Marroni, NP; Miguel, FM; Picada, JN; Schemitt, EG, 2022)
"Atherosclerosis is a hallmark of cardiovascular disease, and lifestyle strongly impacts its onset and progression."1.72TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis. ( Blanco, R; Daimiel, L; Dávalos, A; Díez-Ricote, L; Micó, V; Ordovás, JM; Ruiz-Valderrey, P; Tomé-Carneiro, J, 2022)
"Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver diseases characterized by steatosis, inflammation, and fibrosis."1.72Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. ( Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N, 2022)
"Inflammation drives the pathogenesis of nonalcoholic steatohepatitis (NASH)."1.62Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation. ( Alpini, G; Francis, H; Glaser, S; Li, H; Li, Q; Matthews, DR; Wu, C; Zhou, J, 2021)
"Choline is a key nutrient in fetal brain development."1.62Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. ( Balser, M; D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Walker, VK, 2021)
"Liraglutide treatment did not prevent lipid deposition in the liver of MCD-fed mice but limited the accumulation of C16 and C24-ceramide/sphingomyelin species."1.62The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet. ( Bochaton-Piallat, ML; De Vito, C; Dibner, C; Gaïa, N; Jornayvaz, FR; Lazarevic, V; Loizides-Mangold, U; Montandon, SA; Perroud, E; Schrenzel, J; Somm, E, 2021)
"Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies."1.56The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates. ( Chen, J; Cui, A; Gao, J; Han, J; Ji, S; Li, J; Li, Y; Liu, Z; Ma, F; Ma, X; Tai, P; Wang, G; Wang, T; Xue, Y, 2020)
"Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer."1.56A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet. ( Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M, 2020)
"We report a rare case of a prostate cancer patient with incidentally detected Peyronie disease."1.56Peyronie Disease as an Example of Nononcological, Inflammatory Uptake of 18F-Fluorocholine in Patient With Prostate Cancer. ( Cegla, P; Czepczyński, R; Kubiak, A; Witkowska, K, 2020)
"Choline is a dietary component that is crucial for normal cellular function."1.56Effects of choline supplementation on liver biology, gut microbiota, and inflammation in Helicobacter pylori-infected mice. ( Cao, M; Chen, J; Huang, M; Li, S; Liu, Y; Wu, D; Wu, M; Yan, S; Yu, Z; Zhao, J; Zhou, J, 2020)
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in western countries, with a continuously rising incidence."1.51Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis. ( Bennek, E; Candels, LS; Elfers, C; Gassler, N; Heymann, F; Kilic, K; Mohs, A; Penders, J; Schneider, KM; Schneider, LB; Trautwein, C, 2019)
"Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH)."1.51Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease. ( Carvajal, S; Casals, E; Casals, G; Fernández-Varo, G; González de la Presa, B; Jiménez, W; Morales-Ruíz, M; Oró, D; Parra, M; Pastor, Ó; Perramón, M; Puntes, V; Ribera, J, 2019)
"Choline was not significantly altered in MetS."1.48Changes to trimethylamine-N-oxide and its precursors in nascent metabolic syndrome. ( Huet, B; Jialal, I; Lent-Schochet, D; McLaughlin, M; Silva, R, 2018)
"Choline is an essential nutrient that is required for synthesis of the main eukaryote phospholipid, phosphatidylcholine."1.48Choline transport links macrophage phospholipid metabolism and inflammation. ( Bennett, SAL; Fullerton, MD; Ghorbani, P; LeBlond, ND; Margison, KD; Nguyen, T; Nunes, JRC; O'Dwyer, C; Snider, SA; Xu, H, 2018)
" Several works reported that the bioavailability of DHA to the brain is higher when DHA is acylated to phospholipid."1.46Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro. ( Bernoud-Hubac, N; Fourrier, C; Greenhalgh, AD; Guichardant, M; Joffre, C; Lagarde, M; Layé, S; Remus-Borel, J, 2017)
"MCD diet resulted in steatohepatitis and increased miR-155 expression in total liver, hepatocytes and Kupffer cells."1.42MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. ( Bala, S; Catalano, D; Csak, T; Iracheta-Vellve, A; Kodys, K; Lippai, D; Szabo, G, 2015)
"In healthy term newborns with chorioamnionitis, MRS ratios shortly after birth may provide evidence of occult neuroinflammation, which may be associated with worse performance on 1-year neurodevelopmental tests."1.42Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis. ( Bentzley, JP; Brown, T; Hope, K; Jenkins, DD; Johnson, CB; Katikaneni, LD; Lambert, D; Morgan, PS; Mulvihill, DM; Ramakrishnan, V; Rollins, LG, 2015)
"Choline was described to potentiate the antinociceptive action of aspirin at small doses in several inflammatory pain models."1.40Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide. ( Pan, ZY; Wang, H, 2014)
"Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation."1.40Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. ( Rezazadeh, A; Yazdanparast, R, 2014)
"Inflammation is closely associated with pathogenesis of various metabolic disorders, cardiovascular diseases, and cancers."1.39Combined NMR and GC-MS analyses revealed dynamic metabolic changes associated with the carrageenan-induced rat pleurisy. ( An, Y; Lei, H; Li, H; Tang, H; Wang, Y; Zhang, L, 2013)
"Rats with the metabolic syndrome have ineffective inflammation-resolving mechanisms that represent plausible reasons for the exaggerated and persistent PCD."1.39Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. ( Britton, SL; Chawla, A; Feng, X; Koch, LG; Matthay, MA; Maze, M; Su, X; Terrando, N; Yan, Y, 2013)
"Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis."1.38Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012)
"Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world."1.38Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. ( Camporez, JP; Eisenbarth, SC; Elinav, E; Flavell, RA; Gordon, JI; Hao, L; Henao-Mejia, J; Hoffman, HM; Jin, C; Jurczak, MJ; Kau, AL; Mehal, WZ; Shulman, GI; Strowig, T; Thaiss, CA, 2012)
"Quercetin (50 mg/kg) was given by oral route daily."1.38Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. ( González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D, 2012)
"The pathogenesis of non-alcoholic steatohepatitis is still unclear."1.37Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. ( Han, F; Kong, LB; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, SX, 2011)
"Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models."1.37Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011)
"Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult."1.37Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011)
"Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks."1.36Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010)
"The treatment with choline showed significant reduction in symptom/drug score and improvement in PC(20) FEV1 compared to baseline or standard pharmacotherapy (p<0."1.36Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma. ( Arora, N; Gaur, SN; Mehta, AK; Singh, BP, 2010)
"Steatohepatitis was induced by feeding wild-type or IL-6(-/-) mice for 5 weeks with a methionine and choline-deficient (MCD) diet."1.35IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. ( Carpentier, S; Danjoux, M; Garcia, V; Levade, T; Mas, E; Ségui, B, 2009)
"Fibrosis is a major complication of chronic inflammation, as seen in Crohn's disease and ulcerative colitis, two forms of inflammatory bowel diseases."1.34Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. ( Chakravarti, S; Wu, F, 2007)
"When choline (2 mg/kg) was coadministered with aspirin (9."1.33Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005)
"Nonalcoholic fatty liver (NAFL) and steatohepatitis (NASH) may accompany obesity, diabetes, parenteral nutrition, jejeuno-ileal bypass, and chronic inflammatory bowel disease."1.33Glutathione-enhancing agents protect against steatohepatitis in a dietary model. ( Chen, TS; de Villiers, WJ; Im, HJ; McClain, CJ; Oz, HS, 2006)
"Pre-treatment with choline salicylate and colchicine reduced swelling while pre-treatment with dipyridamole increased edema following cryoglobulin inoculation."1.27Cryoglobulin-induced inflammation. ( Denko, CW, 1985)

Research

Studies (164)

TimeframeStudies, this research(%)All Research%
pre-19906 (3.66)18.7374
1990's1 (0.61)18.2507
2000's16 (9.76)29.6817
2010's69 (42.07)24.3611
2020's72 (43.90)2.80

Authors

AuthorsStudies
Corkill, DJ1
Hunt, AN1
Hinrichs, MJ1
White, N1
Rebelatto, M1
Roskos, L1
Nys, J1
Scott, A1
Robinson, MJ1
Ryan, P1
Postle, AD1
Sleeman, MA1
Lee, N1
Heo, YJ1
Choi, SE1
Jeon, JY1
Han, SJ1
Kim, DJ1
Kang, Y1
Lee, KW1
Kim, HJ2
Wan, Q1
Peng, H1
Lyu, J1
Liu, F1
Cheng, C1
Qiao, Y1
Deng, J1
Zheng, H1
Wang, Y9
Zou, C1
Liu, X2
Li, C3
Zhu, L2
Dai, Y1
Zhang, Z2
Huang, L2
Wang, TJ1
Fu, P1
Li, Y9
Wang, J7
Jiang, C1
Xin, SL1
Yu, YY1
Miguel, FM1
Picada, JN1
da Silva, JB1
Schemitt, EG1
Colares, JR1
Hartmann, RM1
Marroni, CA1
Marroni, NP1
Arora, P1
Singh, K1
Kumari, M1
Trivedi, R1
Zhu, B1
Li, H9
Lu, B1
Guo, X3
Wu, C4
Wang, F1
Li, Q3
Xie, L1
Glaser, S2
Francis, H2
Alpini, G2
Luo, T1
Liu, D2
Guo, Z2
Chen, P1
Ou, C1
Chen, M1
Tan, YY1
Yue, SR1
Lu, AP1
Zhang, L4
Ji, G1
Liu, BC1
Wang, RR1
Lee, GR1
Lee, HI1
Kim, N1
Lee, J1
Kwon, M1
Kang, YH1
Song, HJ1
Yeo, CY1
Jeong, W1
Grodin, EN1
Nieto, SJ1
Meredith, LR1
Burnette, E1
O'Neill, J1
Alger, J1
London, ED1
Miotto, K1
Evans, CJ1
Irwin, MR1
Ray, LA1
Kaufmann, B1
Kui, L1
Reca, A1
Leszczynska, A1
Kim, AD1
Booshehri, LM1
Wree, A1
Friess, H1
Hartmann, D1
Broderick, L1
Hoffman, HM3
Feldstein, AE2
Seike, T1
Boontem, P1
Yanagi, M1
Li, S2
Kido, H1
Yamamiya, D1
Nakagawa, H1
Okada, H1
Yamashita, T1
Harada, K1
Kikuchi, M1
Shiraishi, Y1
Ozaki, N1
Kaneko, S1
Yamashima, T1
Mizukoshi, E1
Zhang, Y8
Ye, S1
Lu, W1
Zhong, J1
Leng, Y1
Yang, T1
Luo, J1
Xu, W1
Zhang, H3
Kong, L3
Baker, JA1
Breit, KR1
Bodnar, TS1
Weinberg, J1
Thomas, JD2
Zhou, S1
Xue, J2
Shan, J1
Hong, Y1
Zhu, W1
Nie, Z1
Ji, N1
Luo, X1
Zhang, T2
Ma, W1
Hu, J1
Zheng, Y2
Ying, H1
Ma, H1
Li, L3
Zhao, Y4
Morozova, MV1
Borisova, MA1
Snytnikova, OA1
Achasova, KM1
Litvinova, EA1
Tsentalovich, YP1
Kozhevnikova, EN1
Xu, J1
Zhao, M1
Jin, A1
Cheng, A1
Jiang, X2
Li, K2
Lin, J1
Meng, X1
Zheng, L1
Díez-Ricote, L1
Ruiz-Valderrey, P1
Micó, V1
Blanco, R1
Tomé-Carneiro, J1
Dávalos, A1
Ordovás, JM1
Daimiel, L1
Xu, L1
Zhang, O1
Zhang, F2
Song, M1
Ma, M1
Ding, R1
Li, D1
Dong, Z1
Jin, S2
Han, W1
Ding, C1
Aljobaily, N1
Krutsinger, K1
Viereckl, MJ1
Joly, R1
Menlove, B1
Cone, B1
Suppes, A1
Han, Y1
Gao, W1
Wu, J1
Xu, Y3
Qi, S1
Liu, W4
Liu, P1
Shi, S1
Wang, H11
Zhang, Q2
Wang, S2
Rein-Fischboeck, L1
Pohl, R1
Haberl, EM1
Mages, W1
Girke, P1
Liebisch, G1
Krautbauer, S1
Buechler, C1
Tu, R1
Xia, J1
Zhen, Q1
Liang, Q1
Lu, Z1
Bian, C1
Zhao, X4
Lv, S1
Su, X2
Li, W1
Wang, X4
Pan, B1
Tacconi, E1
Palma, G1
De Biase, D1
Luciano, A1
Barbieri, M1
de Nigris, F1
Bruzzese, F1
Oates, JR1
Sawada, K1
Giles, DA1
Alarcon, PC1
Damen, MSMA1
Szabo, S1
Stankiewicz, TE1
Moreno-Fernandez, ME1
Divanovic, S1
Hurley, L1
Jauhal, J1
Ille, S1
Pull, K1
Malysheva, OV2
Jadavji, NM1
Liu, N1
Zhong, Y1
Pang, X1
Li, M2
Cannon, RD1
Mei, L1
Cai, X1
Ji, P1
Mohammed, S1
Thadathil, N1
Ohene-Marfo, P1
Tran, AL1
Van Der Veldt, M1
Georgescu, C1
Oh, S1
Nicklas, EH1
Wang, D2
Haritha, NH1
Luo, W1
Janknecht, R1
Miller, BF1
Wren, JD1
Freeman, WM1
Deepa, SS1
Arshad, U1
Husnain, A1
Poindexter, MB1
Zimpel, R1
Perdomo, MC1
Santos, JEP2
Povero, D1
Lazic, M1
McBride, C1
Ambrus-Aikelin, G1
Stansfield, R1
Johnson, CD1
Santini, AM1
Pranadinata, RF1
McGeough, MD1
Stafford, JA1
Veal, JM1
Bain, G1
Zhou, H1
Niu, B1
Wu, X1
Chu, W1
Zhou, Y1
Chen, Z1
Mi, Y1
Liu, Y8
Li, P2
Judd, JM1
Jasbi, P1
Winslow, W1
Serrano, GE1
Beach, TG1
Klein-Seetharaman, J1
Velazquez, R1
Lee, YK1
Park, JE1
Lee, M1
Mifflin, R1
Novak, R1
Hardwick, JP1
Guo, L1
Chen, Q2
Gao, Y2
Jiang, H1
Zhou, F1
Xu, M1
Kim, DY2
Park, JY1
Gee, HY1
Cuño-Gómiz, C1
de Gregorio, E1
Tutusaus, A1
Rider, P1
Andrés-Sánchez, N1
Colell, A1
Morales, A2
Marí, M1
Lopreiato, V3
Vailati-Riboni, M2
Bellingeri, A1
Khan, I1
Farina, G1
Parys, C2
Loor, JJ4
Carvajal, S1
Perramón, M1
Oró, D1
Casals, E1
Fernández-Varo, G1
Casals, G1
Parra, M1
González de la Presa, B1
Ribera, J1
Pastor, Ó1
Morales-Ruíz, M1
Puntes, V1
Jiménez, W1
Bielas, R1
Mielańczyk, A1
Skonieczna, M1
Mielańczyk, Ł1
Neugebauer, D1
Kusuda, R1
Carreira, EU1
Ulloa, L2
Cunha, FQ1
Kanashiro, A1
Cunha, TM1
Bollatti, JM1
Zenobi, MG1
Artusso, NA1
Lopez, AM1
Nelson, CD1
Barton, BA1
Staples, CR1
Hunter, SK3
Hoffman, MC3
D'Alessandro, A2
Noonan, K2
Wyrwa, A1
Freedman, R3
Law, AJ3
Boban, J1
Thurnher, MM1
Brkic, S1
Lendak, D1
Bugarski Ignjatovic, V1
Todorovic, A1
Kozic, D1
Yamauchi, A1
Tone, T1
Toledo, A1
Igarashi, K1
Sugimoto, K1
Miyai, H1
Deng, D1
Nakamura, J1
Lim, HS1
Kaku, T1
Hirano, E1
Shindo, T1
Fuchs, CD1
Krivanec, S1
Steinacher, D1
Mlitz, V1
Wahlström, A1
Stahlman, M1
Claudel, T2
Scharnagl, H1
Stojakovic, T1
Marschall, HU1
Trauner, M2
Cui, A1
Li, J2
Ji, S1
Ma, F1
Wang, G1
Xue, Y1
Liu, Z1
Gao, J1
Han, J1
Tai, P1
Wang, T1
Chen, J4
Ma, X1
Shuai, W1
Wen, J1
Li, X5
Xiang, J1
Eudy, BJ1
McDermott, CE1
Fernandez, G1
Mathews, CE1
Lai, J1
da Silva, RP1
Cegla, P1
Kubiak, A1
Witkowska, K1
Czepczyński, R1
Takatani, N1
Kono, Y1
Beppu, F1
Okamatsu-Ogura, Y1
Yamano, Y1
Miyashita, K1
Hosokawa, M1
Olivari, L1
Riccardi, N1
Rodari, P1
Angheben, A1
Artioli, P1
Salgarello, M1
Esposito, G1
Schiattarella, GG1
Jubinville, É1
Milad, N1
Maranda-Robitaille, M1
Lafrance, MA1
Pineault, M1
Lamothe, J1
Routhier, J1
Beaulieu, MJ1
Aubin, S1
Laplante, M1
Morissette, MC1
Moretti, A1
Paoletta, M1
Liguori, S1
Bertone, M1
Toro, G1
Iolascon, G1
Somm, E1
Montandon, SA1
Loizides-Mangold, U1
Gaïa, N1
Lazarevic, V1
De Vito, C1
Perroud, E1
Bochaton-Piallat, ML1
Dibner, C1
Schrenzel, J1
Jornayvaz, FR1
Wu, D1
Cao, M1
Yu, Z1
Wu, M1
Zhou, J3
Yan, S2
Huang, M1
Zhao, J2
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Zhang, J2
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Xue, L1
Liu, L2
Yan, X2
Huang, S1
Xu, T1
Ji, F1
Ming, F1
Cheng, J1
Zhao, H2
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y5
Wei, J1
Zhu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C3
Lin, Y1
Dong, Y1
Wu, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
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Wendel Garcia, PD1
Fumeaux, T1
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Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
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Wang, L4
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Yang, K2
Zhai, C1
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Lao, X1
Sun, J1
Ma, N1
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Ohkubo, K1
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Fujitaka, Y1
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Matsumoto, KI1
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van der Boom, T1
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Zepeda-Palacio, C1
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Estrada-Mena, FJ1
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Kodavanti, UP1
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Shen, Z1
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Gao, K2
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Ma, P1
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Vukelic, M1
Laloo, A1
Kyttaris, VC1
Chen, R1
Xun, J1
Hu, Z1
Huang, Q2
Steinhart, C1
Shen, Y1
Lu, H1
Mansuri, A1
Lokhande, K1
Kore, S1
Gaikwad, S1
Nawani, N1
Swamy, KV1
Junnarkar, M1
Pawar, S1
Shaheen, MY1
Basudan, AM1
Niazy, AA1
van den Beucken, JJJP1
Jansen, JA1
Alghamdi, HS1
Gao, Q2
Cao, Y1
Jia, X1
Xu, S1
Lu, C2
Zhu, H2
Melku, M1
Abebe, G1
Teketel, A1
Asrie, F1
Yalew, A1
Biadgo, B1
Kassa, E1
Damtie, D1
Anlay, DZ1
Ahmed, MFE1
Ramadan, H1
Seinige, D1
Kehrenberg, C1
Abd El-Wahab, A1
Volkmann, N1
Kemper, N1
Schulz, J1
Hu, MY1
Wu, YN1
McEvoy, MP1
Wang, YF1
Cong, WL1
Liu, LP1
Li, XX1
Zhou, CL1
Chen, WM1
Wei, KL1
Tung, SY1
Shen, CH1
Chang, TS1
Yen, CW1
Hsieh, YY1
Chiu, WN1
Hu, JH1
Lu, SN1
Hung, CH1
Alakavuklar, MA1
Fuqua, C1
Luo, KL1
Underwood, RS1
Greenwald, I1
Elashiry, MM1
Elashiry, M1
Zeitoun, R1
Elsayed, R1
Tian, F1
Saber, SE1
Elashry, SH1
Tay, FR1
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Maciel, M1
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Jobling, MG1
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Woods, CM1
Sincock, SA1
McVeigh, AL1
Gregory, MJ1
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Roderburg, C1
Roy, S1
Bartneck, M1
Schrammen, P1
Diaz, MB1
Ehling, J1
Gremse, F1
Koppe, C1
Lammers, T1
Kiessling, F1
Van Best, N1
Pabst, O1
Courtois, G1
Linkermann, A1
Krautwald, S1
Neumann, UP1
Tacke, F1
Green, DR1
Longerich, T1
Frey, N1
Luedde, M1
Bluher, M1
Herzig, S1
Heikenwalder, M1
Luedde, T1
Wahlang, B1
Perkins, JT1
Petriello, MC1
Hoffman, JB1
Stromberg, AJ1
Hennig, B1
Giovacchini, G1
Samanes Gajate, AM1
Messa, C1
Fazio, F1
Hitchon, CA1
El-Gabalawy, HS1
Bezabeh, T1
Mehta, AK3
Gaur, SN3
Singh, BP3
Zeisel, SH2
da Costa, KA1
Mas, E1
Danjoux, M1
Garcia, V1
Carpentier, S1
Ségui, B1
Levade, T1
Mu, YP1
Ogawa, T1
Kawada, N1
Schillaci, O1
Calabria, F1
Tavolozza, M1
Cicciò, C1
Carlani, M1
Caracciolo, CR1
Danieli, R1
Orlacchio, A1
Simonetti, G1
Luyendyk, JP1
Sullivan, BP1
Guo, GL1
Le, C1
van de Weijer, EP1
Pos, FJ1
Vogel, WV1
Caballero, F1
Fernández, A1
Matías, N1
Martínez, L1
Fucho, R1
Elena, M1
Caballeria, J1
Fernández-Checa, JC1
García-Ruiz, C1
Laitinen, IE1
Luoto, P1
Någren, K1
Marjamäki, PM1
Silvola, JM1
Hellberg, S1
Laine, VJ1
Ylä-Herttuala, S1
Knuuti, J1
Roivainen, A1
Haque, JA1
McMahan, RS1
Campbell, JS1
Shimizu-Albergine, M1
Wilson, AM1
Botta, D1
Bammler, TK1
Beyer, RP1
Montine, TJ1
Yeh, MM1
Kavanagh, TJ1
Fausto, N1
Cai, B1
Deitch, EA1
Nan, YM1
Han, F1
Kong, LB1
Zhao, SX1
Wang, RQ1
Wu, WJ1
TORDA, C1
WOLFF, HG1
Chaim, OM1
da Silveira, RB1
Trevisan-Silva, D1
Ferrer, VP1
Sade, YB1
Bóia-Ferreira, M1
Gremski, LH1
Gremski, W1
Senff-Ribeiro, A1
Takahashi, HK1
Toledo, MS1
Nader, HB1
Veiga, SS1
Giuliani, D1
Ottani, A1
Altavilla, D1
Bazzani, C1
Squadrito, F1
Guarini, S1
Musso, G1
Gambino, R1
Cassader, M1
Yong-Ping, S1
Jin-Da, W1
Ru-Huan, W1
Xiang-Di, Z1
Hai-Tao, Y1
Hai, W1
Takenaka, S1
Shinoda, J1
Asano, Y1
Aki, T1
Miwa, K1
Ito, T1
Yokoyama, K1
Iwama, T1
Bagdas, D1
Sonat, FA1
Hamurtekin, E1
Sonal, S1
Gurun, MS1
Min, AK1
Kim, MK1
Kim, HS1
Seo, HY1
Lee, KU1
Kim, JG1
Park, KG1
Lee, IK1
Henao-Mejia, J1
Elinav, E1
Jin, C1
Hao, L1
Mehal, WZ1
Strowig, T1
Thaiss, CA1
Kau, AL1
Eisenbarth, SC1
Jurczak, MJ1
Camporez, JP1
Shulman, GI1
Gordon, JI1
Flavell, RA1
Zhu, A1
Marcus, DM1
Shu, HK1
Shim, H1
Marcolin, E1
San-Miguel, B1
Vallejo, D1
Tieppo, J1
Marroni, N1
González-Gallego, J1
Tuñón, MJ1
Mellergård, J1
Tisell, A1
Dahlqvist Leinhard, O1
Blystad, I1
Landtblom, AM1
Blennow, K1
Olsson, B1
Dahle, C1
Ernerudh, J1
Lundberg, P1
Vrethem, M1
Terrando, N1
Yan, Y1
Chawla, A1
Koch, LG1
Britton, SL1
Matthay, MA1
Maze, M1
BROH-KAHN, RH1
DAMMANN, F1
Su, DM1
Wang, RH1
Oz, HS1
Im, HJ1
Chen, TS1
de Villiers, WJ1
McClain, CJ1
Melek, E1
Ozyer, U1
Erol, I1
Alehan, F1
Muhteşem Ağildere, A1
Kubota, K1
Furumoto, S1
Iwata, R1
Fukuda, H1
Kawamura, K1
Ishiwata, K1
Daniel, C1
Sartory, N1
Zahn, N1
Geisslinger, G1
Radeke, HH1
Stein, JM1
Roc, AC1
Ances, BM1
Chawla, S1
Korczykowski, M1
Wolf, RL1
Kolson, DL1
Detre, JA1
Poptani, H1
Ofek, K1
Krabbe, KS1
Evron, T1
Debecco, M1
Nielsen, AR1
Brunnsgaad, H1
Yirmiya, R1
Soreq, H1
Pedersen, BK1
Chakravarti, S1
Detopoulou, P1
Panagiotakos, DB1
Antonopoulou, S1
Pitsavos, C1
Stefanadis, C1
Davis, KA1
Masella, J1
Blennerhassett, MG1
Saxena, U1
Nagpurkar, A1
Mookerjea, S1
Denko, CW1
Jonas, FJ1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Molecular Imaging of Plaque Vulnerability Using 18F-choline PET-MRI in Carotid Artery Atherosclerosis Patients[NCT02640313]Phase 314 participants (Anticipated)Interventional2015-12-31Recruiting
The Role of Microbiome Reprogramming on Liver Fat Accumulation[NCT03914495]57 participants (Actual)Interventional2019-05-21Terminated (stopped due to PI carefully considered multiple factors and decided to close study to any further enrollment.)
Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan[NCT04671186]47 participants (Actual)Interventional2020-09-07Completed
Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery[NCT03391401]204 participants (Actual)Observational2018-03-01Completed
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692]Phase 3750 participants (Anticipated)Interventional2016-11-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for choline and Innate Inflammatory Response

ArticleYear
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO.
    CNS & neurological disorders drug targets, 2024, Volume: 23, Issue:1

    Topics: Choline; Cognitive Dysfunction; Gastrointestinal Microbiome; Humans; Inflammation; Stroke; Thrombosi

2024
Microbiota Effect on Trimethylamine N-Oxide Production: From Cancer to Fitness-A Practical Preventing Recommendation and Therapies.
    Nutrients, 2023, Jan-21, Volume: 15, Issue:3

    Topics: Animals; Cardiovascular Diseases; Choline; Inflammation; Methylamines; Microbiota; Neoplasms

2023
Choline: An Essential Nutrient for Skeletal Muscle.
    Nutrients, 2020, Jul-18, Volume: 12, Issue:7

    Topics: Adipose Tissue; Animals; Autophagy; Calcium; Choline; Eating; Humans; Inflammation; Muscle Proteins;

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies.
    Journal of cardiovascular translational research, 2021, Volume: 14, Issue:6

    Topics: Animals; Carnitine; Choline; Gastrointestinal Microbiome; Glucose; Humans; Hypertension; Inflammatio

2021
Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development.
    Clinical nutrition ESPEN, 2021, Volume: 43

    Topics: Animals; Brain; Child Development; Choline; COVID-19; Developmental Disabilities; Dietary Supplement

2021
Choline: an essential nutrient for public health.
    Nutrition reviews, 2009, Volume: 67, Issue:11

    Topics: Adolescent; Adult; Aged; Animals; Breast Neoplasms; Child; Child, Preschool; Choline; Choline Defici

2009
Novel insights for systemic inflammation in sepsis and hemorrhage.
    Mediators of inflammation, 2010, Volume: 2010

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Choline; Cytokines; Dise

2010
Melanocortins and the cholinergic anti-inflammatory pathway.
    Advances in experimental medicine and biology, 2010, Volume: 681

    Topics: Animals; Choline; Humans; Inflammation; Melanocortins; Myocardial Infarction; Myocardial Reperfusion

2010
Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes.
    Annual review of medicine, 2011, Volume: 62

    Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Bile Acids and Salts; Carbohydrate Metabolism;

2011
Application of metabolic PET imaging in radiation oncology.
    Radiation research, 2012, Volume: 177, Issue:4

    Topics: Acetates; Carbon Radioisotopes; Carcinoma; Choline; Confounding Factors, Epidemiologic; Female; Fluo

2012

Trials

7 trials available for choline and Innate Inflammatory Response

ArticleYear
Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial.
    Addiction biology, 2022, Volume: 27, Issue:4

    Topics: Alcohol Drinking; Alcoholism; Animals; Aspartic Acid; C-Reactive Protein; Choline; Creatine; Humans;

2022
Effects of rumen-protected choline on the inflammatory and metabolic status and health of dairy cows during the transition period.
    Journal of dairy science, 2020, Volume: 103, Issue:5

    Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Choline; Diet; Dietary Supplements; Female;

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Supplemental Choline Modulates Growth Performance and Gut Inflammation by Altering the Gut Microbiota and Lipid Metabolism in Weaned Piglets.
    The Journal of nutrition, 2021, 01-04, Volume: 151, Issue:1

    Topics: Animals; Bile Acids and Salts; Choline; Cytokines; Dietary Supplements; Female; Gastrointestinal Mic

2021
Serum choline and butyrylcholinesterase changes in response to endotoxin in calves receiving intravenous choline administration.
    Research in veterinary science, 2019, Volume: 125

    Topics: Acute-Phase Reaction; Administration, Intravenous; Animals; Biomarkers; Butyrylcholinesterase; Cattl

2019
Association between change in normal appearing white matter metabolites and intrathecal inflammation in natalizumab-treated multiple sclerosis.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adult; Antibodies, Monoclonal, Humanized; Choline; Creatine; Female; Humans; Inflammation; Interleuk

2012
Cholinergic status modulations in human volunteers under acute inflammation.
    Journal of molecular medicine (Berlin, Germany), 2007, Volume: 85, Issue:11

    Topics: Acetylcholinesterase; Acute Disease; Adult; Aged; Attention; Biomarkers; Butyrylcholinesterase; Chol

2007

Other Studies

147 other studies available for choline and Innate Inflammatory Response

ArticleYear
Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.
    Clinical science (London, England : 1979), 2021, 11-26, Volume: 135, Issue:22

    Topics: Animals; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Autoantibodies; Bronchoalveolar L

2021
Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease.
    Biochemical and biophysical research communications, 2022, 01-15, Volume: 588

    Topics: Amino Acids; Animals; Benzhydryl Compounds; Choline; Cytokines; Diet, High-Fat; Disease Models, Anim

2022
Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine-Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.
    Journal of magnetic resonance imaging : JMRI, 2022, Volume: 56, Issue:5

    Topics: Animals; Area Under Curve; Biopsy; Choline; Diet; Inflammation; Liver; Magnetic Resonance Imaging; M

2022
Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Acute Disease; Animals; Astrocytes; Brain Injuries; Cerebral Hemorrhage; Choline; Diet; Disease Mode

2022
Ubiquitin-specific peptidase 10 ameliorates hepatic steatosis in nonalcoholic steatohepatitis model by restoring autophagic activity.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2022, Volume: 54, Issue:8

    Topics: Animals; Autophagy; Choline; Fibrosis; Inflammation; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic

2022
Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet.
    Inflammation, 2022, Volume: 45, Issue:5

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases;

2022
Temporal profile of serum metabolites and inflammation following closed head injury in rats is associated with HPA axis hyperactivity.
    Metabolomics : Official journal of the Metabolomic Society, 2022, 04-29, Volume: 18, Issue:5

    Topics: Animals; Choline; Corticosterone; Head Injuries, Closed; Hypothalamo-Hypophyseal System; Inflammatio

2022
Indole supplementation ameliorates MCD-induced NASH in mice.
    The Journal of nutritional biochemistry, 2022, Volume: 107

    Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Indoles; In

2022
Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE
    Journal of molecular and cellular cardiology, 2022, Volume: 170

    Topics: Animals; Atherosclerosis; Cholesterol; Cholesterol, LDL; Choline; Inflammation; Leukocytes, Mononucl

2022
The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 103

    Topics: Animals; Chemokine CCL3; Chemokines; Choline; Gastrointestinal Microbiome; Inflammation; Liver; Meth

2022
Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.
    Journal of cellular physiology, 2022, Volume: 237, Issue:9

    Topics: Animals; Choline; Cytoplasmic Dyneins; Diet; Disease Models, Animal; Dyneins; Inflammation; Liver; M

2022
Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis.
    Cellular and molecular gastroenterology and hepatology, 2022, Volume: 14, Issue:4

    Topics: Adenosine; Amino Acids; Animals; Caspases; Choline; Hepatitis; Humans; Inflammasomes; Inflammation;

2022
Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis.
    Cellular and molecular gastroenterology and hepatology, 2022, Volume: 14, Issue:4

    Topics: Aldehyde Dehydrogenase; Animals; Cathepsins; Choline; Hepatocytes; Humans; Inflammation; Lipids; Lys

2022
RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling.
    Hepatology (Baltimore, Md.), 2023, 05-01, Volume: 77, Issue:5

    Topics: Animals; Carcinoma, Hepatocellular; Choline; DEAD-box RNA Helicases; Diet, High-Fat; Disease Models,

2023
Choline Supplementation Modifies the Effects of Developmental Alcohol Exposure on Immune Responses in Adult Rats.
    Nutrients, 2022, Jul-13, Volume: 14, Issue:14

    Topics: Animals; Animals, Newborn; Choline; Cytokines; Dietary Supplements; Ethanol; Female; Hippocampus; Im

2022
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1.
    Nutrients, 2022, Aug-15, Volume: 14, Issue:16

    Topics: AMP-Activated Protein Kinases; Animals; Atherosclerosis; Choline; Gastrointestinal Microbiome; Infla

2022
Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation.
    Nutrients, 2022, Sep-15, Volume: 14, Issue:18

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases;

2022
Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice.
    Scientific reports, 2022, 09-29, Volume: 12, Issue:1

    Topics: Animals; Brain; Choline; Colitis; Fabaceae; Female; Gastrointestinal Microbiome; Glycine; Inflammati

2022
Residual Risk of Trimethylamine-N-Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy.
    Journal of the American Heart Association, 2022, 10-04, Volume: 11, Issue:19

    Topics: C-Reactive Protein; Choline; Humans; Inflammation; Lipids; Methylamines; Oxides; Platelet Aggregatio

2022
TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis.
    International journal of molecular sciences, 2022, Oct-11, Volume: 23, Issue:20

    Topics: Animals; Atherosclerosis; Betaine; Cardiovascular Diseases; Carnitine; Choline; Humans; Inflammation

2022
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
    Journal of molecular endocrinology, 2023, Jan-01, Volume: 70, Issue:1

    Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis

2023
Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor.
    Nutrients, 2022, Dec-30, Volume: 15, Issue:1

    Topics: Animals; Body Weight; Choline; Choline Deficiency; Diet; Fibrosis; Humans; Inflammation; Liver; Live

2022
Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
    International journal of biological macromolecules, 2023, Mar-01, Volume: 230

    Topics: Animals; Choline; Diet; Glucans; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alco

2023
Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis.
    Gene, 2023, Apr-05, Volume: 859

    Topics: Adiposity; Animals; Cholesterol Esters; Choline; Disease Models, Animal; Fatty Acid Synthases; Fatty

2023
Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Animals; Choline; Choline Deficiency; Diabetes Mellitus, Type 2; Diet; Fibrosis; Inflammation; Methi

2023
Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Animals; Choline; Diet; Drugs, Chinese Herbal; Endotoxemia; Gastrointestinal Microbiome; Inflammatio

2022
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla

2023
Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring.
    Nutrients, 2023, Mar-23, Volume: 15, Issue:7

    Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Inflammation; Ischemic Stroke; Lactation;

2023
The nano-windmill exerts superior anti-inflammatory effects via reducing choline uptake to inhibit macrophage activation.
    Cell proliferation, 2023, Volume: 56, Issue:10

    Topics: Anti-Inflammatory Agents; Choline; Humans; Inflammation; Macrophage Activation; Macrophages; Nucleic

2023
Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis.
    Molecular cancer research : MCR, 2023, 09-01, Volume: 21, Issue:9

    Topics: Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Female; Incidence; Inflammation; Liver;

2023
Effect of source and amount of rumen-protected choline on hepatic metabolism during induction of fatty liver in dairy cows.
    Journal of dairy science, 2023, Volume: 106, Issue:10

    Topics: Animals; Cattle; Cattle Diseases; Cholesterol; Choline; Diet; Dietary Supplements; Fatty Acids; Fatt

2023
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
    The Journal of pharmacology and experimental therapeutics, 2023, Volume: 386, Issue:2

    Topics: Animals; Caspase 1; Choline; Inflammasomes; Inflammation; Interleukin-1beta; Liver Cirrhosis; Mice;

2023
iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice.
    Scientific reports, 2023, 07-13, Volume: 13, Issue:1

    Topics: Animals; Choline; Disease Models, Animal; Inflammation; Isotope Labeling; Liver; Liver Cirrhosis; Me

2023
Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels.
    Acta neuropathologica, 2023, Volume: 146, Issue:4

    Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Choline; Humans; Inflammation; Mic

2023
Deletion of hepatic small heterodimer partner ameliorates development of nonalcoholic steatohepatitis in mice.
    Journal of lipid research, 2023, Volume: 64, Issue:11

    Topics: Animals; Cholesterol; Choline; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knoc

2023
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease.
    Biochemical pharmacology, 2023, Volume: 217

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Choline; Colitis; Colon; Cytidine Diphosphate Choline;

2023
Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production.
    Experimental & molecular medicine, 2023, Volume: 55, Issue:11

    Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Hepatitis; Humans; Inflammation; Lactobaci

2023
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice.
    Biology of sex differences, 2023, Nov-14, Volume: 14, Issue:1

    Topics: Animals; Choline; Diet, High-Fat; Fatty Liver; Female; Fibrosis; Humans; Inflammation; Liver Cirrhos

2023
Inflammation and oxidative stress transcription profiles due to in vitro supply of methionine with or without choline in unstimulated blood polymorphonuclear leukocytes from lactating Holstein cows.
    Journal of dairy science, 2019, Volume: 102, Issue:11

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Antioxidants; Cattle; Choline; D

2019
Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease.
    Scientific reports, 2019, 09-06, Volume: 9, Issue:1

    Topics: Adipokines; Animals; Body Weight; Cerium; Cholesterol; Choline; Diet; Fatty Acids; Gene Expression R

2019
Choline supported poly(ionic liquid) graft copolymers as novel delivery systems of anionic pharmaceuticals for anti-inflammatory and anti-coagulant therapy.
    Scientific reports, 2019, 10-08, Volume: 9, Issue:1

    Topics: Cell Line; Choline; Drug Carriers; Drug Delivery Systems; Escherichia coli; Free Radicals; Gene Expr

2019
Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.
    Brain research, 2020, 01-15, Volume: 1727

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Choline; Cyclic GMP; Dinoprostone; Freund's Adjuva

2020
Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development.
    Psychological medicine, 2021, Volume: 51, Issue:3

    Topics: Brain; C-Reactive Protein; Choline; Female; Fetal Development; Fetus; Gestational Age; Humans; Infan

2021
Neurometabolic Remodeling in Chronic Hiv Infection: a Five-Year Follow-up Multi-Voxel Mrs Study.
    Scientific reports, 2019, 12-24, Volume: 9, Issue:1

    Topics: Adult; Algorithms; Anti-HIV Agents; Aspartic Acid; Brain; Brain Neoplasms; Cell Communication; Cell

2019
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
    Biomedical research (Tokyo, Japan), 2020, Volume: 41, Issue:1

    Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate C

2020
Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Choline; Di

2020
The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates.
    Diabetes, 2020, Volume: 69, Issue:8

    Topics: Animals; Body Weight; Cell Line; Choline; Fibroblast Growth Factors; Fibrosis; Inflammation; Liver;

2020
High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction.
    Journal of cardiac failure, 2020, Volume: 26, Issue:8

    Topics: Animals; Choline; Diet; Fibrosis; Heart Failure; Humans; Inflammation; Mice; Mice, Inbred C57BL; Str

2020
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
    The Journal of nutritional biochemistry, 2020, Volume: 81

    Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver;

2020
Peyronie Disease as an Example of Nononcological, Inflammatory Uptake of 18F-Fluorocholine in Patient With Prostate Cancer.
    Clinical nuclear medicine, 2020, Volume: 45, Issue:7

    Topics: Aged; Choline; Humans; Inflammation; Male; Middle Aged; Penile Induration; Positron Emission Tomogra

2020
Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice.
    Biochemical and biophysical research communications, 2020, 07-23, Volume: 528, Issue:2

    Topics: Alanine Transaminase; Amino Acids; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; B

2020
COVID-19 pneumonia: increased choline uptake with 18F-choline PET/CT.
    European journal of nuclear medicine and molecular imaging, 2020, Volume: 47, Issue:10

    Topics: Choline; Coronavirus Infections; COVID-19; Disease Progression; Humans; Inflammation; Lung; Macropha

2020
Feeding Diastolic Dysfunction: Is It a Bug?
    Journal of cardiac failure, 2020, Volume: 26, Issue:8

    Topics: Animals; Choline; Diet; Fibrosis; Heart Diseases; Heart Failure; Inflammation; Mice; Stroke Volume

2020
Critical importance of dietary methionine and choline in the maintenance of lung homeostasis during normal and cigarette smoke exposure conditions.
    American journal of physiology. Lung cellular and molecular physiology, 2020, 08-01, Volume: 319, Issue:2

    Topics: Animals; Bronchoalveolar Lavage Fluid; Choline; Cytokines; Diabetes Mellitus, Type 2; Diet; Female;

2020
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet.
    Translational research : the journal of laboratory and clinical medicine, 2021, Volume: 227

    Topics: Animals; Choline; Diet; Glucagon-Like Peptide-1 Receptor; Inflammation; Liraglutide; Liver; Methioni

2021
Effects of choline supplementation on liver biology, gut microbiota, and inflammation in Helicobacter pylori-infected mice.
    Life sciences, 2020, Oct-15, Volume: 259

    Topics: Animals; Cholesterol, LDL; Choline; Diet; Dietary Supplements; Feces; Female; Gastrointestinal Micro

2020
Methyl donor supply to heat stress-challenged polymorphonuclear leukocytes from lactating Holstein cows enhances 1-carbon metabolism, immune response, and cytoprotective gene network abundance.
    Journal of dairy science, 2020, Volume: 103, Issue:11

    Topics: Animals; Antioxidants; Carbon; Cattle; Cattle Diseases; Choline; Diet; Female; Gene Regulatory Netwo

2020
Maternal body condition influences neonatal calf whole-blood innate immune molecular responses to ex vivo lipopolysaccharide challenge.
    Journal of dairy science, 2021, Volume: 104, Issue:2

    Topics: Animals; Animals, Newborn; Antioxidants; Body Constitution; Cattle; Cattle Diseases; Choline; Female

2021
The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Alanine Transaminase; Amino Acids; Animals; Cell Adhesion; Choline; Diet; Disease Models, Animal; En

2020
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
    Lipids in health and disease, 2020, Dec-14, Volume: 19, Issue:1

    Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-F

2020
Inflammation-driven glial alterations in the cuprizone mouse model probed with diffusion-weighted magnetic resonance spectroscopy at 11.7 T.
    NMR in biomedicine, 2021, Volume: 34, Issue:4

    Topics: Animals; Brain; Choline; Cuprizone; Diffusion Magnetic Resonance Imaging; Female; Immunohistochemist

2021
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
    Life sciences, 2021, Apr-01, Volume: 270

    Topics: Animals; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Hep G2 Cells; Humans; Inflammati

2021
Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation.
    Scientific reports, 2021, 03-05, Volume: 11, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Carnitine; Choline; Cross-Sectional Studies; Fatty Acids; Female; Human

2021
Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis.
    Cellular and molecular gastroenterology and hepatology, 2021, Volume: 12, Issue:2

    Topics: Animals; Caspases, Initiator; Choline; Diet; Disease Progression; Hepatocytes; Inflammation; Lipopol

2021
Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV.
    Journal of psychiatric research, 2021, Volume: 141

    Topics: Child, Preschool; Choline; Female; Humans; Inflammation; Intelligence; Male; Mothers; Pregnancy; Pre

2021
Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation.
    The American journal of pathology, 2021, Volume: 191, Issue:10

    Topics: Animals; Cell Line, Tumor; Choline; Diet; Epithelial Cells; Feeding Behavior; Humans; Inflammation;

2021
High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine
    Science (New York, N.Y.), 2021, 08-13, Volume: 373, Issue:6556

    Topics: Animals; Cell Hypoxia; Choline; Colon; Diet, High-Fat; Energy Metabolism; Epithelial Cells; Escheric

2021
Choline Supplementation During Pregnancy Protects Against Gestational Lipopolysaccharide-Induced Inflammatory Responses.
    Reproductive sciences (Thousand Oaks, Calif.), 2018, Volume: 25, Issue:1

    Topics: Animals; Choline; Cytokines; Dietary Supplements; Female; Inflammation; Lipopolysaccharides; Placent

2018
[Choline improves lipopolysaccharide-induced central nervous system inflammatory response and cognitive dysfunction in mice].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2017, May-20, Volume: 37, Issue:5

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium-Binding Proteins; Central Nervous System;

2017
Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro.
    Journal of neuroinflammation, 2017, Aug-24, Volume: 14, Issue:1

    Topics: Animals; Cell Line, Transformed; Choline; Docosahexaenoic Acids; Inflammation; Inflammation Mediator

2017
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
    PloS one, 2017, Volume: 12, Issue:9

    Topics: Adipose Tissue; Animals; CD18 Antigens; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Hep

2017
Changes to trimethylamine-N-oxide and its precursors in nascent metabolic syndrome.
    Hormone molecular biology and clinical investigation, 2018, Apr-18, Volume: 35, Issue:2

    Topics: Adult; Aged; Biomarkers; Carnitine; Choline; Female; Humans; Inflammation; Male; Metabolic Syndrome;

2018
Choline transport links macrophage phospholipid metabolism and inflammation.
    The Journal of biological chemistry, 2018, 07-20, Volume: 293, Issue:29

    Topics: Animals; Cells, Cultured; Choline; Inflammation; Lipogenesis; Macrophages; Mice, Inbred C57BL; Organ

2018
Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.
    The Journal of infectious diseases, 2018, 09-22, Volume: 218, Issue:9

    Topics: Atherosclerosis; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Choline; Female; Gastrointes

2018
Methionine and choline supply during the peripartal period alter polymorphonuclear leukocyte immune response and immunometabolic gene expression in Holstein cows.
    Journal of dairy science, 2018, Volume: 101, Issue:11

    Topics: Animals; Biomarkers; Cattle; Choline; Diet; Dietary Supplements; Female; Gene Expression Regulation;

2018
Walnut Protein Hydrolysates Play a Protective Role on Neurotoxicity Induced by d-Galactose and Aluminum Chloride in Mice.
    Molecules (Basel, Switzerland), 2018, Sep-10, Volume: 23, Issue:9

    Topics: Aluminum Chloride; Amino Acids; Animals; Antioxidants; Behavior, Animal; Body Weight; Choline; Feedi

2018
Choline Regulates the Function of Bovine Immune Cells and Alters the mRNA Abundance of Enzymes and Receptors Involved in Its Metabolism
    Frontiers in immunology, 2018, Volume: 9

    Topics: Acetylcholine; Adaptive Immunity; Animals; Betaine; Cattle; Cell Proliferation; Cells, Cultured; Cho

2018
Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Calcium; Cholesterol; Choline; Diet; Disease Progression; Dynamins; Feeding Beha

2019
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
    International journal of molecular sciences, 2019, Jan-14, Volume: 20, Issue:2

    Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Micro

2019
Simian immunodeficiency virus transiently increases brain temperature in rhesus monkeys: detection with magnetic resonance spectroscopy thermometry.
    Magnetic resonance in medicine, 2019, Volume: 81, Issue:5

    Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Inflammation; Inositol; Macaca mulatta; Magne

2019
Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.
    Toxicon : official journal of the International Society on Toxinology, 2019, Apr-15, Volume: 162

    Topics: Animals; Cell Adhesion Molecules; Cholesterol; Choline; Diet, High-Fat; Hepatobiliary Elimination; I

2019
Cholinesterase's activities of infected mice by Brucella ovis.
    Microbial pathogenesis, 2019, Volume: 132

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Brucella ovis; Brucellosis; Butyrylcholinesterase; Cat

2019
Choline uptake is vital for IL-1β-driven inflammation.
    Nature reviews. Rheumatology, 2019, Volume: 15, Issue:6

    Topics: Choline; Humans; Inflammation; Interleukin-18; Interleukin-1beta; Macrophages

2019
Epoxyeicosatrienoic acids alleviate methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in mice.
    Scandinavian journal of immunology, 2019, Volume: 90, Issue:3

    Topics: Animals; Cell Line; Cell Line, Tumor; Chemokines; Choline; Cytochrome P-450 CYP2J2; Cytochrome P-450

2019
Combined NMR and GC-MS analyses revealed dynamic metabolic changes associated with the carrageenan-induced rat pleurisy.
    Journal of proteome research, 2013, Dec-06, Volume: 12, Issue:12

    Topics: Acute-Phase Proteins; Animals; Carrageenan; Choline; Citric Acid Cycle; Fatty Acids; Gas Chromatogra

2013
Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Amides; Angiotensin II; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Fumarates; Immunoenz

2013
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes.
    Iranian biomedical journal, 2014, Volume: 18, Issue:1

    Topics: Animals; Antioxidants; Ascorbic Acid; Chelating Agents; Choline; Diet; Ethylenediamines; Fatty Liver

2014
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
    Biochimica et biophysica acta, 2014, Volume: 1842, Issue:7

    Topics: Adipogenesis; Adipose Tissue; Animals; Choline; Disease Models, Animal; Fatty Acids; Fatty Acids, No

2014
Choline inadequacy impairs trophoblast function and vascularization in cultured human placental trophoblasts.
    Journal of cellular physiology, 2014, Volume: 229, Issue:8

    Topics: Apoptosis; Biomarkers; Cell Differentiation; Cell Line; Cell Membrane; Cell Proliferation; Choline;

2014
Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide.
    International immunopharmacology, 2014, Volume: 20, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Choline; Cytokines; Drug Synergism; Edema;

2014
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
    International journal of molecular sciences, 2014, Apr-04, Volume: 15, Issue:4

    Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M

2014
Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014, Volume: 90

    Topics: Animals; Bacterial Infections; Cell Line, Tumor; Choline; Diagnosis, Differential; Female; Fibrosarc

2014
Intranasal administration of a combination of choline chloride, vitamin C, and selenium attenuates the allergic effect in a mouse model of airway disease.
    Free radical biology & medicine, 2014, Volume: 73

    Topics: Administration, Intranasal; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Asthma;

2014
Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes.
    Molecular neurobiology, 2016, Volume: 53, Issue:2

    Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cerebral Cortex;

2016
Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:4

    Topics: Adult; Arachidonic Acid; Betaine; Choline; Cystic Fibrosis; Deuterium; Docosahexaenoic Acids; Female

2015
Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation.
    Translational psychiatry, 2015, Apr-14, Volume: 5

    Topics: Adult; Age Factors; Anisotropy; Aspartic Acid; Case-Control Studies; Choline; Creatine; Diffusion Te

2015
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Choline; Diet; Disease Models, Animal; F

2015
Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis.
    Journal of perinatology : official journal of the California Perinatal Association, 2015, Volume: 35, Issue:12

    Topics: Basal Ganglia; Brain; Choline; Chorioamnionitis; Creatine; Dipeptides; Female; Healthy Volunteers; H

2015
A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice.
    Disease models & mechanisms, 2015, Volume: 8, Issue:12

    Topics: Aging; Alanine Transaminase; Animals; Bile Ducts; Biomarkers; Body Weight; Cell Differentiation; Cel

2015
Plasma Concentrations of Trimethylamine-N-oxide Are Directly Associated with Dairy Food Consumption and Low-Grade Inflammation in a German Adult Population.
    The Journal of nutrition, 2016, Volume: 146, Issue:2

    Topics: Adult; Animals; Betaine; C-Reactive Protein; Choline; Dairy Products; Diet; Diet Surveys; Feeding Be

2016
Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adult; Aged; Betaine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Choline; Female; Fibr

2016
TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice.
    Molecular medicine reports, 2016, Volume: 13, Issue:3

    Topics: Animals; Chemokines; Choline; Diet; Down-Regulation; Fibrosis; Inflammation; Liver; Liver Cirrhosis;

2016
Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice.
    Journal of affective disorders, 2016, May-15, Volume: 196

    Topics: Animals; Anxiety; Cholesterol; Choline; Depression; Diet; Female; Inflammation; Mice; Mice, Inbred C

2016
Dietary choline regulates antibacterial activity, inflammatory response and barrier function in the gills of grass carp (Ctenopharyngodon idella).
    Fish & shellfish immunology, 2016, Volume: 52

    Topics: Animal Feed; Animals; Carps; Choline; Diet; Dietary Supplements; Fish Diseases; Fish Proteins; Gene

2016
Inflammatory effects of TNFα are counteracted by X-ray irradiation and AChE inhibition in mouse micromass cultures.
    Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B

    Topics: Acetylcholinesterase; Animals; Cell Differentiation; Cells, Cultured; Choline; Cholinesterase Inhibi

2016
Imaging Intraplaque Inflammation in Carotid Atherosclerosis With 18F-Fluorocholine Positron Emission Tomography-Computed Tomography: Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation.
    Circulation. Cardiovascular imaging, 2016, Volume: 9, Issue:5

    Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Asymptomatic Diseases; Biomarkers; Ca

2016
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
    Nature communications, 2016, 06-21, Volume: 7

    Topics: Adipocytes; Adipose Tissue, White; Animals; Apoptosis; Body Mass Index; Caspase 8; Choline; Choline

2016
Dietary choline deficiency and excess induced intestinal inflammation and alteration of intestinal tight junction protein transcription potentially by modulating NF-κB, STAT and p38 MAPK signaling molecules in juvenile Jian carp.
    Fish & shellfish immunology, 2016, Volume: 58

    Topics: Animal Feed; Animals; Carps; Choline; Cytokines; Diet; Dose-Response Relationship, Drug; Fish Diseas

2016
A compromised liver alters polychlorinated biphenyl-mediated toxicity.
    Toxicology, 2017, 04-01, Volume: 380

    Topics: Adipokines; Animals; Aroclors; Biomarkers; Blood Glucose; Cardiovascular Diseases; Choline; Diet; Di

2017
Increased C-11 choline uptake in pagetic bone in a patient with coexisting skeletal metastases from prostate cancer.
    Clinical nuclear medicine, 2008, Volume: 33, Issue:11

    Topics: Aged; Bone Neoplasms; Carbon Radioisotopes; Cell Proliferation; Choline; Diagnosis, Differential; Fe

2008
Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation.
    Rheumatology international, 2009, Volume: 29, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Choline; Creatine; Fuco

2009
Choline supplementation reduces oxidative stress in mouse model of allergic airway disease.
    European journal of clinical investigation, 2009, Volume: 39, Issue:10

    Topics: Administration, Inhalation; Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage

2009
Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma.
    Immunobiology, 2010, Volume: 215, Issue:7

    Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Cells, Cultured; Choline; Cytokines; Eosinophi

2010
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.
    PloS one, 2009, Nov-20, Volume: 4, Issue:11

    Topics: Animal Feed; Animals; Apoptosis; Choline; Disease Models, Animal; Fatty Liver; Inflammation; Interle

2009
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:2

    Topics: Animals; Choline; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Inflammation; Liver Ci

2010
18F-choline PET/CT physiological distribution and pitfalls in image interpretation: experience in 80 patients with prostate cancer.
    Nuclear medicine communications, 2010, Volume: 31, Issue:1

    Topics: Aged; Aged, 80 and over; Brain; Choline; Humans; Image Interpretation, Computer-Assisted; Inflammati

2010
Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice.
    The American journal of pathology, 2010, Volume: 176, Issue:1

    Topics: Alanine Transaminase; Animals; Blood Coagulation; Blood Coagulation Factors; Chemokine CCL2; Choline

2010
Active inflammation in 18F-methylcholine PET/CT.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:3

    Topics: Aged; Choline; Humans; Inflammation; Male; Neoplasm Metastasis; Positron-Emission Tomography; Prosta

2010
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.
    The Journal of biological chemistry, 2010, Jun-11, Volume: 285, Issue:24

    Topics: Animal Feed; Animals; Ceramides; Choline; Fatty Liver; Glutathione; Inflammation; Lipids; Male; Meth

2010
Uptake of 11C-choline in mouse atherosclerotic plaques.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:5

    Topics: Animals; Apolipoproteins B; Atherosclerosis; Choline; Cryopreservation; Immunohistochemistry; Inflam

2010
Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:12

    Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Antioxidants; Carnitine O-Palmitoyltransferase; Choline;

2010
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:3

    Topics: Adenoviridae; Anilides; Animals; beta-Galactosidase; Choline; Diet; Fatty Liver; Genetic Vectors; In

2011
Apparent curare effect of substances that decrease acetylcholine synthesis.
    The American journal of physiology, 1946, Volume: 147

    Topics: Acetylcholine; Choline; Curare; Inflammation; Nervous System; Nervous System Physiological Phenomena

1946
Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity.
    Biochimica et biophysica acta, 2011, Volume: 1811, Issue:2

    Topics: Animals; Aorta; Cell Membrane; Cells, Cultured; Choline; Endothelial Cells; Inflammation; Insect Pro

2011
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
    European journal of pain (London, England), 2011, Volume: 15, Issue:8

    Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem

2011
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
    Brain tumor pathology, 2011, Volume: 28, Issue:3

    Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe

2011
The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Choline; Cytidine Diphosphate Choline;

2011
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
    Life sciences, 2012, Jan-30, Volume: 90, Issue:5-6

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;

2012
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
    The Journal of nutrition, 2012, Volume: 142, Issue:10

    Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase

2012
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
    Molecular medicine (Cambridge, Mass.), 2013, Feb-08, Volume: 18

    Topics: Animals; Anti-Inflammatory Agents; CD3 Complex; Cell Polarity; Choline; Cognition Disorders; Disease

2013
Choline salicylate: a new, effective, and well-tolerated analgesic, anti-inflammatory, and antipyretic agent.
    International record of medicine, 1960, Volume: 173

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Choline; Drug Combinations; Inflammation; Salicy

1960
[Antiphlogistic percutaneous therapy with choline stearate (chomelan)].
    Die Medizinische, 1955, Feb-19, Volume: 8

    Topics: Choline; Humans; Inflammation; Stearates; Stearic Acids

1955
Antinociceptive effects of choline against acute and inflammatory pain.
    Neuroscience, 2005, Volume: 132, Issue:1

    Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm

2005
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
    Journal of biochemical and molecular toxicology, 2006, Volume: 20, Issue:1

    Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Li

2006
+H-proton-magnetic resonance spectroscopic findings in a patient with acute hemicerebellitis presenting without localized signs: a case report.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2006, Volume: 10, Issue:4

    Topics: Acute Disease; Adolescent; Aspartic Acid; Cerebellar Diseases; Choline; Cranial Fossa, Posterior; Cr

2006
Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation.
    Annals of nuclear medicine, 2006, Volume: 20, Issue:8

    Topics: Animals; Autoradiography; Brain; Choline; Deoxyglucose; Fluorine Radioisotopes; Inflammation; Lung;

2006
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Feb-15, Volume: 178, Issue:4

    Topics: Animals; Antigens, CD; Antigens, Differentiation; Aziridines; Cell Differentiation; Choline; Colitis

2007
Effect of choline chloride in allergen-induced mouse model of airway inflammation.
    The European respiratory journal, 2007, Volume: 30, Issue:4

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Choline; Diseas

2007
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
    Archives of neurology, 2007, Volume: 64, Issue:9

    Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Atrophy; Biomark

2007
Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Nov-15, Volume: 179, Issue:10

    Topics: Animals; Aziridines; CD4-Positive T-Lymphocytes; Choline; Chronic Disease; Colitis, Ulcerative; Croh

2007
Is there a new component of the Mediterranean diet that reduces inflammation?
    The American journal of clinical nutrition, 2008, Volume: 87, Issue:2

    Topics: Betaine; Biomarkers; Choline; Confounding Factors, Epidemiologic; Diet Surveys; DNA Methylation; Epi

2008
Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study.
    The American journal of clinical nutrition, 2008, Volume: 87, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Betaine; Biomarkers; C-Reactive Protein; Choli

2008
Acetylcholine metabolism in the inflamed rat intestine.
    Experimental neurology, 1998, Volume: 152, Issue:2

    Topics: Acetylcholine; Animals; Choline; Choline O-Acetyltransferase; Inflammation; Jejunal Diseases; Male;

1998
Contrasting effect of phosphorylcholine-binding protein from rat and rabbit on heparin-lipoprotein interaction: a role of sialic acid.
    Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, Volume: 63, Issue:9

    Topics: Animals; Calcium; Carrier Proteins; Chemical Precipitation; Choline; Drug Interactions; Electrophore

1985
Cryoglobulin-induced inflammation.
    Agents and actions, 1985, Volume: 17, Issue:1

    Topics: Alprostadil; Animals; Choline; Colchicine; Cryoglobulins; Crystallization; Dipyridamole; Drug Combin

1985
[Experiences on the use of medicinal plant extracts for traumatic and inflammatory swelling of the soft tissue].
    Deutsches medizinisches Journal, 1966, Oct-05, Volume: 17, Issue:19

    Topics: Allantoin; Choline; Humans; Hydantoins; Inflammation; Plants, Medicinal; Wounds and Injuries

1966