choline has been researched along with Hyperhomocysteinemia in 17 studies
Hyperhomocysteinemia: Condition in which the plasma levels of homocysteine and related metabolites are elevated (
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperhomocysteinemia (Hhcy) is a biochemical alteration with plasma levels of homocysteine higher than 15 µmol/L, associated with atherosclerosis, and with vascular thrombosis by disrupting endothelial cells." | 7.91 | A novel approach in the management of hyperhomocysteinemia. ( Goyal, A; Gupta, JK; Narayan Yadav, H; Qureshi, SS, 2019) |
| "The results indicated that betaine or beet could completely suppress the hyperhomocysteinemia induced by choline deficiency resulting from stimulating the homocysteine removal by both remethylation and cystathionine formation." | 7.81 | [Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats]. ( Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q, 2015) |
| "The mechanism by which feeding a higher casein diet results in resistance to choline deprivation-induced hyperhomocysteinemia was investigated in rats." | 7.78 | Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Mori, M; Morita, T; Sugiyama, K, 2012) |
| "5% serine, or both on hyperhomocysteinemia induced by deprivation of dietary choline or by dietary addition of 0." | 7.77 | Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2011) |
| "75% L-methionine for 7 d to determine the effects of dietary choline level on experimental hyperhomocysteinemia." | 7.74 | Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| " The hyperhomocysteinemia induced by choline deprivation was effectively suppressed by betaine or methionine supplementation." | 7.74 | Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| "To clarify the role of cholin- and histaminergic shifts in the onset of circulatory and functional gastric disturbances associated with erosive-ulcer gastroduodenal lesions in myocardial infarction (MI)." | 7.73 | [Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction]. ( Chernin, VV; Osadchiĭ, VA, 2005) |
| "Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease." | 7.72 | Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. ( Arning, E; Bottiglieri, T; Devlin, AM; Faraci, FM; Lentz, SR; Rozen, R, 2004) |
| "Folate deficiency, choline deficiency and methionine loading synergistically induced hyperhomocysteinemia up to 69." | 7.71 | Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia. ( Hirosawa, K; Hishida, A; Ikegaya, N; Katoh, S; Kimura, M; Kumagai, H, 2002) |
| " Other research has shown that betaine and choline seem to be more effective than folate at reducing hyperhomocysteinemia and impacting cardiovascular outcomes suggesting they may be limiting." | 4.89 | The nutritional burden of methylation reactions. ( Bertolo, RF; McBreairty, LE, 2013) |
| "Hyperhomocysteinemia (Hhcy) is a biochemical alteration with plasma levels of homocysteine higher than 15 µmol/L, associated with atherosclerosis, and with vascular thrombosis by disrupting endothelial cells." | 3.91 | A novel approach in the management of hyperhomocysteinemia. ( Goyal, A; Gupta, JK; Narayan Yadav, H; Qureshi, SS, 2019) |
| "The results indicated that betaine or beet could completely suppress the hyperhomocysteinemia induced by choline deficiency resulting from stimulating the homocysteine removal by both remethylation and cystathionine formation." | 3.81 | [Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats]. ( Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q, 2015) |
| "The mechanism by which feeding a higher casein diet results in resistance to choline deprivation-induced hyperhomocysteinemia was investigated in rats." | 3.78 | Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Mori, M; Morita, T; Sugiyama, K, 2012) |
| "5% serine, or both on hyperhomocysteinemia induced by deprivation of dietary choline or by dietary addition of 0." | 3.77 | Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2011) |
| " Cysteine supplementation also significantly suppressed hyperhomocysteinemia induced by choline-deprived 10C with an increase in plasma cysteine concentration but not that induced by 25C+0." | 3.75 | Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels. ( Kawakami, Y; Morita, T; Ohuchi, S; Sugiyama, K, 2009) |
| "75% L-methionine for 7 d to determine the effects of dietary choline level on experimental hyperhomocysteinemia." | 3.74 | Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| " The hyperhomocysteinemia induced by choline deprivation was effectively suppressed by betaine or methionine supplementation." | 3.74 | Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| "To clarify the role of cholin- and histaminergic shifts in the onset of circulatory and functional gastric disturbances associated with erosive-ulcer gastroduodenal lesions in myocardial infarction (MI)." | 3.73 | [Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction]. ( Chernin, VV; Osadchiĭ, VA, 2005) |
| "Hyperhomocysteinemia, a proposed risk factor for cardiovascular disease, is also observed in other common disorders." | 3.72 | Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. ( Castro, C; Chen, Z; Garrow, T; Genest, J; Laryea, MD; Lussier-Cacan, S; Mar, MH; Rozen, R; Schwahn, BC; Wendel, U; Zeisel, SH, 2003) |
| "Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease." | 3.72 | Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. ( Arning, E; Bottiglieri, T; Devlin, AM; Faraci, FM; Lentz, SR; Rozen, R, 2004) |
| "Folate deficiency, choline deficiency and methionine loading synergistically induced hyperhomocysteinemia up to 69." | 3.71 | Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia. ( Hirosawa, K; Hishida, A; Ikegaya, N; Katoh, S; Kimura, M; Kumagai, H, 2002) |
| "Choline is an essential nutrient and can also be obtained by de novo synthesis via an oestrogen responsive pathway." | 2.77 | Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. ( Bonham, MP; Duffy, ME; McCormack, JM; McNulty, H; Molloy, AM; Robson, PJ; Scott, JM; Strain, JJ; Ueland, PM; Wallace, JM; Walsh, PM; Ward, M, 2012) |
| "Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden." | 2.66 | Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery. ( Bergamini, C; Capelli, I; Cappuccilli, M; Cianciolo, G; Conte, D; Donati, G; Giacomelli, FA; La Manna, G; Natali, T, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Cappuccilli, M | 1 |
| Bergamini, C | 1 |
| Giacomelli, FA | 1 |
| Cianciolo, G | 1 |
| Donati, G | 1 |
| Conte, D | 1 |
| Natali, T | 1 |
| La Manna, G | 1 |
| Capelli, I | 1 |
| Qureshi, SS | 1 |
| Gupta, JK | 1 |
| Goyal, A | 1 |
| Narayan Yadav, H | 1 |
| Jadavji, NM | 1 |
| Bahous, RH | 1 |
| Deng, L | 1 |
| Malysheva, O | 1 |
| Grand'maison, M | 1 |
| Bedell, BJ | 1 |
| Caudill, MA | 1 |
| Rozen, R | 5 |
| Liu, Y | 3 |
| Han, F | 1 |
| Sun, L | 1 |
| Lu, J | 1 |
| Wang, Q | 1 |
| Sugiyama, K | 6 |
| Huang, Z | 1 |
| Setoue, M | 2 |
| Ohuchi, S | 3 |
| Morita, T | 5 |
| Kawakami, Y | 1 |
| Strakova, J | 1 |
| Williams, KT | 1 |
| Gupta, S | 1 |
| Schalinske, KL | 1 |
| Kruger, WD | 1 |
| Jiracek, J | 1 |
| Li, L | 1 |
| Garrow, TA | 2 |
| Liu, YQ | 2 |
| Wallace, JM | 1 |
| McCormack, JM | 1 |
| McNulty, H | 1 |
| Walsh, PM | 1 |
| Robson, PJ | 1 |
| Bonham, MP | 1 |
| Duffy, ME | 1 |
| Ward, M | 1 |
| Molloy, AM | 1 |
| Scott, JM | 1 |
| Ueland, PM | 1 |
| Strain, JJ | 1 |
| Mori, M | 1 |
| Bertolo, RF | 1 |
| McBreairty, LE | 1 |
| Kumagai, H | 1 |
| Katoh, S | 1 |
| Hirosawa, K | 1 |
| Kimura, M | 1 |
| Hishida, A | 1 |
| Ikegaya, N | 1 |
| Schwahn, BC | 2 |
| Chen, Z | 1 |
| Laryea, MD | 1 |
| Wendel, U | 2 |
| Lussier-Cacan, S | 2 |
| Genest, J | 1 |
| Mar, MH | 2 |
| Zeisel, SH | 2 |
| Castro, C | 2 |
| Garrow, T | 1 |
| Devlin, AM | 1 |
| Arning, E | 1 |
| Bottiglieri, T | 1 |
| Faraci, FM | 1 |
| Lentz, SR | 1 |
| Leclerc, D | 1 |
| Chernin, VV | 1 |
| Osadchiĭ, VA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Medium-term Oral Guanidinoacetic Acid (GAA) Administration on Human Performance, Body Composition, and Metabolic Outcomes in Physically Active Men and Women[NCT01133899] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| [NCT01371357] | Phase 3 | 40 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for choline and Hyperhomocysteinemia
| Article | Year |
|---|---|
Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery.
Topics: Betaine; Cardiovascular Diseases; Choline; Dietary Supplements; DNA Methylation; Eating; Epigenesis, | 2020 |
The nutritional burden of methylation reactions.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Creatine; Diet; Dietary Supplements; Folic Acid; | 2013 |
1 trial available for choline and Hyperhomocysteinemia
| Article | Year |
|---|---|
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Met | 2012 |
14 other studies available for choline and Hyperhomocysteinemia
| Article | Year |
|---|---|
A novel approach in the management of hyperhomocysteinemia.
Topics: Alcohol Oxidoreductases; Animals; Choline; Cytidine Diphosphate Choline; Dietary Supplements; Endoth | 2019 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; | 2014 |
[Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats].
Topics: Amino Acids; Animals; Beta vulgaris; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cho | 2015 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
Topics: Animals; Betaine; Choline; Choline Deficiency; Cysteine; Dietary Supplements; Growth; Homocysteine; | 2008 |
Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Caseins; Choline; Cystathionine beta-Synthase; Cy | 2009 |
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.
Topics: Amino Acids; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta | 2010 |
Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet.
Topics: Animals; Caseins; Choline; Diet; Dietary Supplements; Drug Synergism; Glycine; Hyperhomocysteinemia; | 2011 |
Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats.
Topics: Animals; Caseins; Choline; Choline Deficiency; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Ma | 2012 |
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia.
Topics: Age Factors; Animal Feed; Animals; Choline; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methioni | 2002 |
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Dose-Response Relationship, Drug; Female; Genoty | 2003 |
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Topics: Animals; Aorta; Arterioles; Cerebral Arteries; Choline; Crosses, Genetic; Cysteine; Diet; Endotheliu | 2004 |
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
Topics: Animal Feed; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta | 2004 |
[Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction].
Topics: Adolescent; Adult; Aged; Choline; Disease Progression; Female; Histamine; Humans; Hyperhomocysteinem | 2005 |