choline has been researched along with Hepatic Encephalopathy in 37 studies
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather than MR spectroscopy." | 7.70 | Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. ( Agarwal, VP; Haseler, LJ; McCarthy, DM; Mojtahedzadeh, HN; Reddy, S; Sibbitt, WL, 1998) |
| "In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) and choline (< 2 SDs from normal) with or without increased cerebral glutamine (> 1 SD from normal)--in 20 patients with cirrhosis." | 5.07 | Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. ( Ernst, T; Jacobson, S; Korula, J; Kreis, R; Moats, RA; Ross, BD; Shonk, T; Villamil, F, 1994) |
| " Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather than MR spectroscopy." | 3.70 | Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. ( Agarwal, VP; Haseler, LJ; McCarthy, DM; Mojtahedzadeh, HN; Reddy, S; Sibbitt, WL, 1998) |
| " Decreased myo-inositol and increased glutamine levels were noted to be the most sensitive spectroscopic markers for cirrhotic patients with hepatic encephalopathy (HE)." | 3.70 | Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve. ( Kim, ST; Lee, JH; Lee, YS; Lim, TH; Min, YI; Mun, CW; Seo, DW; Suh, DJ, 1999) |
| "Minimal hepatic encephalopathy (MHE) is diagnosed when hepatic patients perform worse on psychometric tests compared to healthy controls." | 2.78 | Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy. ( El Yamany, SA; Hamisa, MF; Hasan, AM; Soliman, HH; Ziada, DH, 2013) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes." | 2.39 | Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996) |
| "In patients with hepatic encephalopathy, GABA+ levels in the cerebello-thalamo-cortical loop are significantly increased in the cerebellum and significantly decreased in the motor cortex." | 1.91 | J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy. ( Ahn, S; Butz, M; Füllenbach, ND; Häussinger, D; Jördens, MS; Ljimani, A; Oeltzschner, G; Schnitzler, A; Thiel, TA; Wilms, LM; Wittsack, HJ; Zöllner, HJ, 2023) |
| "Acute-on-chronic liver failure (ACLF), acute liver failure (ALF) and chronic liver disease (CLD) are common forms of liver failure and present with similar clinical profiles." | 1.35 | In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. ( Gupta, RK; Nath, K; Radha Krishna, Y; Saraswat, VA; Thomas, MA; Verma, A, 2008) |
| "Minimal hepatic encephalopathy (MHE) is frequently diagnosed in patients with liver cirrhosis who do not show overt clinical cirrhosis-associated neurological deficits." | 1.33 | Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy. ( Graziadei, IW; Hinterhuber, H; Kugener, A; Marksteiner, J; Mattedi, M; Mechtcheriakov, S; Schocke, M; Vogel, W, 2005) |
| "6 patients with liver cirrhosis were included in this pilot study." | 1.33 | [Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)]. ( Gregor, M; Hass, HG; Hösl, F; Kaiser, S; Nägele, T; Seeger, U, 2005) |
| "Hepatic encephalopathy is a common problem in cirrhosis." | 1.30 | Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. ( Andus, T; Feuerbach, S; Fründ, R; Geissler, A; Held, P; Hollerbach, S; Holstege, A; Lock, G; Schölmerich, J, 1997) |
| "Also, patients with Wilson disease and portosystemic shunting had lower myo-inositol-creatine ratios than did patients with Wilson disease and no portosystemic shunting (P < ." | 1.30 | Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy. ( Hoogenraad, TU; Mali, WP; Van Den Heuvel, AG; Van der Grond, J; Van Rooij, LG; Van Wassenaer-van Hall, HN, 1997) |
| "Patients with hepatic encephalopathy were distinguished from controls by significant reduction in levels of cerebral nucleoside triphosphate (2." | 1.30 | Proton-decoupled 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy. ( Bluml, S; Ross, BD; Tan, J; Zuckerman, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (16.22) | 18.7374 |
| 1990's | 13 (35.14) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Claeys, W | 1 |
| Van Hoecke, L | 1 |
| Geerts, A | 1 |
| Van Vlierberghe, H | 1 |
| Lefere, S | 1 |
| Van Imschoot, G | 1 |
| Van Wonterghem, E | 1 |
| Ghesquière, B | 1 |
| Vandenbroucke, RE | 1 |
| Van Steenkiste, C | 1 |
| Zöllner, HJ | 1 |
| Thiel, TA | 1 |
| Füllenbach, ND | 1 |
| Jördens, MS | 1 |
| Ahn, S | 1 |
| Wilms, LM | 1 |
| Ljimani, A | 1 |
| Häussinger, D | 1 |
| Butz, M | 1 |
| Wittsack, HJ | 1 |
| Schnitzler, A | 1 |
| Oeltzschner, G | 1 |
| Chaganti, J | 1 |
| Zeng, G | 1 |
| Tun, N | 1 |
| Lockart, I | 1 |
| Abdelshaheed, C | 1 |
| Cysique, L | 1 |
| Montagnese, S | 1 |
| Brew, BJ | 1 |
| Danta, M | 1 |
| Ciarlariello, VB | 1 |
| Fujino, MVT | 1 |
| Almeida, MD | 1 |
| Barsottini, OGP | 1 |
| Pedroso, JL | 1 |
| Ziada, DH | 1 |
| Soliman, HH | 1 |
| El Yamany, SA | 1 |
| Hamisa, MF | 1 |
| Hasan, AM | 1 |
| Chavarria, L | 2 |
| Cordoba, J | 2 |
| Razek, AA | 1 |
| Abdalla, A | 1 |
| Ezzat, A | 1 |
| Megahed, A | 1 |
| Barakat, T | 1 |
| Zahr, NM | 1 |
| Sullivan, EV | 1 |
| Rohlfing, T | 1 |
| Mayer, D | 1 |
| Collins, AM | 1 |
| Luong, R | 1 |
| Pfefferbaum, A | 1 |
| Singhal, A | 1 |
| Nagarajan, R | 1 |
| Kumar, R | 1 |
| Huda, A | 1 |
| Gupta, RK | 4 |
| Thomas, MA | 4 |
| Herman-Sucharska, I | 1 |
| Grzybek, M | 1 |
| Grochowska, A | 1 |
| Karcz, P | 1 |
| Urbanik, A | 1 |
| Bokemeyer, M | 1 |
| Ding, XQ | 1 |
| Goldbecker, A | 1 |
| Raab, P | 1 |
| Heeren, M | 1 |
| Arvanitis, D | 1 |
| Tillmann, HL | 1 |
| Lanfermann, H | 1 |
| Weissenborn, K | 1 |
| Srivastava, A | 1 |
| Yadav, SK | 1 |
| Borkar, VV | 1 |
| Yadav, A | 1 |
| Yachha, SK | 1 |
| Rathore, RK | 1 |
| Pandey, CM | 1 |
| Alonso, J | 1 |
| García-Martínez, R | 1 |
| Simón-Talero, M | 1 |
| Ventura-Cots, M | 1 |
| Ramírez, C | 1 |
| Torrens, M | 1 |
| Vargas, V | 1 |
| Rovira, A | 1 |
| GROS, H | 1 |
| Mechtcheriakov, S | 1 |
| Schocke, M | 1 |
| Kugener, A | 1 |
| Graziadei, IW | 1 |
| Mattedi, M | 1 |
| Hinterhuber, H | 1 |
| Vogel, W | 1 |
| Marksteiner, J | 1 |
| Hass, HG | 1 |
| Nägele, T | 1 |
| Seeger, U | 2 |
| Hösl, F | 1 |
| Gregor, M | 2 |
| Kaiser, S | 2 |
| Saksena, S | 1 |
| Rai, V | 1 |
| Saraswat, VA | 2 |
| Rathore, RS | 1 |
| Purwar, A | 1 |
| Kumar, M | 1 |
| Verma, A | 1 |
| Radha Krishna, Y | 1 |
| Nath, K | 1 |
| Danielsen, ER | 2 |
| Michaelis, T | 1 |
| Ross, BD | 6 |
| Jacobson, S | 1 |
| Villamil, F | 1 |
| Korula, J | 1 |
| Kreis, R | 3 |
| Ernst, T | 1 |
| Shonk, T | 1 |
| Moats, RA | 1 |
| Blüml, S | 2 |
| Geissler, A | 1 |
| Lock, G | 1 |
| Fründ, R | 1 |
| Held, P | 1 |
| Hollerbach, S | 1 |
| Andus, T | 1 |
| Schölmerich, J | 1 |
| Feuerbach, S | 1 |
| Holstege, A | 1 |
| Van Den Heuvel, AG | 1 |
| Van der Grond, J | 1 |
| Van Rooij, LG | 1 |
| Van Wassenaer-van Hall, HN | 1 |
| Hoogenraad, TU | 1 |
| Mali, WP | 1 |
| Laubenberger, J | 1 |
| Bayer, S | 1 |
| Thiel, T | 1 |
| Hennig, J | 1 |
| Langer, M | 1 |
| Zuckerman, E | 1 |
| Tan, J | 1 |
| Haseler, LJ | 1 |
| Sibbitt, WL | 1 |
| Mojtahedzadeh, HN | 1 |
| Reddy, S | 1 |
| Agarwal, VP | 1 |
| McCarthy, DM | 1 |
| Lee, JH | 1 |
| Seo, DW | 1 |
| Lee, YS | 1 |
| Kim, ST | 1 |
| Mun, CW | 1 |
| Lim, TH | 1 |
| Min, YI | 1 |
| Suh, DJ | 1 |
| Taylor-Robinson, SD | 1 |
| Buckley, C | 1 |
| Changani, KK | 1 |
| Hodgson, HJ | 1 |
| Bell, JD | 1 |
| Naegele, T | 1 |
| Grodd, W | 1 |
| Viebahn, R | 1 |
| Klose, U | 1 |
| Seitz, D | 1 |
| Mader, I | 1 |
| Mayer, J | 1 |
| Lauchart, W | 1 |
| Voigt, K | 1 |
| Joyeux, H | 1 |
| Joyeux, A | 1 |
| Raoux, P | 1 |
| Brissac, C | 1 |
| Blanc, F | 1 |
| Solassol, C | 1 |
| Marks, R | 1 |
| Dudley, F | 1 |
| Wan, A | 1 |
| Farrow, NA | 1 |
| Ackerman, Z | 1 |
| Farrow, N | 1 |
| de Graaf, AA | 1 |
| Deutz, NE | 1 |
| Bosman, DK | 1 |
| Chamuleau, RA | 1 |
| de Haan, JG | 1 |
| Bovee, WM | 1 |
| DiPalma, JR | 1 |
| Lieber, CS | 1 |
| Knick, B | 1 |
| Ottenjann, R | 1 |
| Gruner, J | 1 |
| Kanzler, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205] | 40 participants (Anticipated) | Observational | 2019-06-01 | Recruiting | |||
| A Magnetic Resonance Spectroscopy Study of Neuropsychiatric Effects Associated With Cytokines[NCT00001547] | 150 participants | Observational | 1996-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for choline and Hepatic Encephalopathy
| Article | Year |
|---|---|
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy?
Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic | 1996 |
Treatment of alcoholic liver injury.
Topics: Alcoholism; Amino Acids; Choline; Fatty Liver, Alcoholic; Hepatic Encephalopathy; Hepatitis, Alcohol | 1985 |
4 trials available for choline and Hepatic Encephalopathy
| Article | Year |
|---|---|
Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy.
Topics: Adult; Ammonia; Brain; Choline; Creatinine; Female; Gastrointestinal Agents; Gastrointestinal Tract; | 2013 |
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
Topics: Adolescent; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; H | 2014 |
Brain magnetic resonance spectroscopy in episodic hepatic encephalopathy.
Topics: Aged; Brain; Brain Chemistry; Brain Edema; Choline; Female; Follow-Up Studies; Glutamic Acid; Hepati | 2013 |
Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.
Topics: Adult; Brain Chemistry; Choline; Double-Blind Method; Female; Glutamine; Hepatic Encephalopathy; Hum | 1994 |
30 other studies available for choline and Hepatic Encephalopathy
| Article | Year |
|---|---|
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
Topics: Ammonia; Animals; Bile Acids and Salts; Bile Ducts; Brain; Choline; Disease Models, Animal; Glutamin | 2022 |
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Topics: Ammonia; Cerebellum; Choline; gamma-Aminobutyric Acid; Glutamine; Hepatic Encephalopathy; Humans; In | 2023 |
Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE.
Topics: Blood-Brain Barrier; Brain; Choline; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirr | 2023 |
Teaching Video NeuroImages: Hepatic myelopathy: An unusual neurologic complication of hepatic encephalopathy.
Topics: Choline; Gait Disorders, Neurologic; Globus Pallidus; Glutamic Acid; Glutamine; Hepatic Encephalopat | 2019 |
Concomitants of alcoholism: differential effects of thiamine deficiency, liver damage, and food deprivation on the rat brain in vivo.
Topics: Alcoholism; Analysis of Variance; Animals; Brain; Choline; Disease Models, Animal; Ethanol; Food Dep | 2016 |
Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy.
Topics: Adult; Aged; Brain; Choline; Creatine; Female; Hepatic Encephalopathy; Humans; Inositol; Liver; Magn | 2009 |
[Myoinositol trends in HMRS brain spectrum of patients with hepatic encephalopathy].
Topics: Ammonia; Biomarkers; Choline; Creatine; Hepatic Encephalopathy; Humans; Inositol; Liver; Magnetic Re | 2010 |
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders | 2011 |
Serial evaluation of children with ALF with advanced MRI, serum proinflammatory cytokines, thiamine, and cognition assessment.
Topics: Brain; Brain Edema; Case-Control Studies; Child; Child, Preschool; Choline; Cognition; Cognition Dis | 2012 |
[THE VARIOUS FORMS OF HEPATIC COMA AND THEIR TREATMENT].
Topics: Adrenal Cortex Hormones; Anti-Infective Agents, Local; Choline; Drug Therapy; Folic Acid; Fructose; | 1965 |
Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy.
Topics: Aspartic Acid; Cerebral Cortex; Choline; Creatinine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli | 2005 |
[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)].
Topics: Adult; Ammonia; Brain; Choline; Combined Modality Therapy; Creatinine; Diet, Protein-Restricted; Dip | 2005 |
Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure.
Topics: Adolescent; Adult; Anisotropy; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circ | 2008 |
In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Chronic Disease; Creat | 2008 |
Three methods of calibration in quantitative proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Body Water; Brain; Brain Chemistry; Brain Injuries; Calibration; Choline; Crea | 1995 |
Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Hepatic Encephalopathy; Humans; I | 1997 |
Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Diagnosis, Differential; Fem | 1997 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Proton-decoupled 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy.
Topics: Adenosine Triphosphate; Adult; Aged; Brain; Choline; Ethanolamine; Female; Hepatic Encephalopathy; H | 1998 |
Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy.
Topics: Administration, Oral; Adult; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopa | 1998 |
Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Energy Metabolism; Female; Gl | 1999 |
Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy.
Topics: Adult; Aged; Brain; Choline; Creatinine; Electroencephalography; Female; Glutamic Acid; Glutamine; H | 1999 |
MR imaging and (1)H spectroscopy of brain metabolites in hepatic encephalopathy: time-course of renormalization after liver transplantation.
Topics: Adult; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Glutamic Acid; Glutamine; Hepati | 2000 |
[Metabolic disorders in experimental hepatic insufficiency and parenteral feeding].
Topics: 5-Hydroxytryptophan; Amino Acids; Ammonia; Animals; Blood Coagulation; Blood Transfusion; Choline; D | 1977 |
Trimethylamine metabolism in liver disease.
Topics: Choline; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methylamines | 1978 |
Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.
Topics: Aspartic Acid; Brain; Choline; Female; Glucose; Glutamates; Glutamic Acid; Glutamine; Hepatic Enceph | 1992 |
Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols.
Topics: Aged; Brain; Choline; Chronic Disease; Data Interpretation, Statistical; Electronic Data Processing; | 1991 |
The use of in vivo proton NMR to study the effects of hyperammonemia in the rat cerebral cortex.
Topics: Ammonia; Animals; Cerebral Cortex; Choline; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalop | 1991 |
Nutritional pharmacology.
Topics: Amino Acids, Branched-Chain; Brain Diseases; Choline; Diet; Dyskinesia, Drug-Induced; Hepatic Enceph | 1985 |
[Dietetic therapy of liver diseases].
Topics: Choline; Chronic Disease; Diet Therapy; Dietary Proteins; Fatty Acids; Fatty Liver; Hepatic Encephal | 1972 |