choline has been researched along with Glioma in 240 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the association of metabolic features of F-fluorocholine in gliomas with histopathological and molecular parameters, progression-free survival (PFS) and overall survival (OS)." | 9.30 | 18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas. ( Amo-Salas, M; Barbella, R; Borrás Moreno, JM; García Vicente, AM; Klein Zampaña, CJ; Mollejo Villanueva, M; Pena Pardo, FJ; Pérez-Beteta, J; Pérez-García, VM; Sandoval Valencia, H; Soriano Castrejón, ÁM; Villena Martín, M, 2019) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 9.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "This meta-analysis indicated 11C-choline has high diagnostic accuracy for the identification of tumor relapse from radiation induced necrosis in gliomas." | 8.98 | Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis. ( Chen, G; Gao, L; Li, T; Xu, W; Zheng, J, 2018) |
| "Twenty-six patients (mean age 16 years, range 8-22 years) with suspected glioma disease progression were evaluated with 18 F-choline PET/MRI." | 8.31 | Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults. ( Al-Khayfawee, A; Bomanji, J; Cockle, JV; Ferrazzoli, V; Fraioli, F; Hyare, H; Shankar, A; Tang, C, 2023) |
| "The aim of this study was to assess the prognostic performance of postoperative 18F-fluorocholine PET/CT in patients with high-grade glioma (HGG)." | 8.12 | Prognostic Potential of Postoperative 18F-Fluorocholine PET/CT in Patients With High-Grade Glioma. Clinical Validation of FuMeGA Postoperative PET Criteria. ( Amo-Salas, M; García Vicente, AM; López Menéndez, C; Pena Pardo, FJ; Pérez-Beteta, J; Soriano Castrejón, ÁM; Villena Martín, M, 2022) |
| "Patients with a previous gross total resection of glioma and the first suspicious or doubtful for recurrence MRI were prospectively included and subjected to 18 F-fluorocholine PET/CT." | 8.12 | Early Recurrence Detection of Glioma Using 18 F-Fluorocholine PET/CT : GliReDe Pilot Study. ( Amo-Salas, M; García Vicente, AM; Lozano Setien, E; Sandoval Valencia, H; Soriano Castrejón, ÁM, 2022) |
| "To investigate the diagnostic accuracy of O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary low-grade gliomas (LGG)." | 8.02 | 18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study. ( Baučić, M; Golubić, AT; Hodolič, M; Huić, D; Mišir Krpan, A; Mrak, G; Nemir, J; Žuvić, M, 2021) |
| "Ischemic complications after resection of high-grade glioma are frequent and may constitute potential cause of false-positive results in postsurgical evaluation using F-fluorocholine PET/CT." | 7.91 | Ischemic Complications After High-Grade Glioma Resection Could Interfere With Residual Tumor Detection With 18F-Fluorocholine PET/CT. ( García Vicente, AM; Martinez Madrigal, MM; Pena Pardo, FJ; Rodriguez Muñoz, MJ; Soriano Castrejón, A, 2019) |
| "The aim of this study is to assess the different metabolic activities characteristic of glioma recurrence and radiation necrosis (RN) and to explore the diagnostic accuracy for differentiation of the two conditions using (11)C-methionine (MET), (11)C-choline (CHO), and (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)." | 7.80 | Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis. ( Asano, Y; Iwama, T; Miwa, K; Nomura, Y; Shinoda, J; Takenaka, S; Yano, H; Yonezawa, S, 2014) |
| "The aim of the present study is to evaluate the role of (11)C-choline positron emission tomography/computed tomography (PET/CT) in detecting tumor recurrence and predicting survival in post-treatment patients with high-grade gliomas." | 7.80 | (11)C-choline PET/CT tumor recurrence detection and survival prediction in post-treatment patients with high-grade gliomas. ( Hu, X; Li, W; Ma, L; Sun, J; Wang, S; Wang, X, 2014) |
| "To study choline metabolism in biopsies from nonenhancing Grade 2 (AS2) and Grade 3 (AS3) astrocytomas to determine whether (1) phosphocholine (PC) dominates in AS3, and (2) PC is associated with proliferation or angiogenesis." | 7.77 | Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma. ( Berger, MS; Chang, SM; Chiu, KS; Chu, PW; Cloyd, CP; McKnight, TR; Phillips, JJ; Smith, KJ, 2011) |
| "This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)." | 7.77 | Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011) |
| "The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ((1)H-MRS)." | 7.75 | Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel (1)H-MRS at 1.5 T. ( Chernov, MF; Hori, T; Iseki, H; Kubo, O; Maruyama, T; Muragaki, Y; Nakamura, R; Ono, Y; Takakura, K; Usukura, M; Yoshida, S, 2009) |
| "PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy." | 7.74 | Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy. ( Ağildere, AM; Atalay, B; Elhan, AH; Geyik, E; Ozen, O; Yerli, H, 2007) |
| " The aim of this study was to determine uptake of the (18)F-labeled PET tracers (18)F-fluorocholine (N,N-dimethyl-N-(18)F-fluoromethyl-2-hydroxyethylammonium), (18)F-fluoro-ethyl-l-tyrosine (FET), and (18)F-FDG in C6 gliomas of the rat and to correlate it with uptake of the anti-extra domain B antibody (131)I-SIP(L19) as a marker of neoangiogenesis." | 7.74 | Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis. ( Alessi, P; Biollaz, G; Buck, A; Neri, D; Pahnke, J; Spaeth, N; Trachsel, E; Treyer, V; Weber, B; Wyss, MT, 2007) |
| "Diffusion tensor imaging and multiple voxel magnetic resonance spectroscopy were performed in the MRI follow-up of a patient with a glioma treated with temozolomide chemotherapy." | 7.74 | Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy. ( Enting, RH; Heesters, MA; Irwan, R; Meiners, LC; Oudkerk, M; Potze, JH; Sijens, PE; van der Graaf, WT, 2007) |
| "9L glioma cells were incubated with [(18)F]FCH and [(14)C]choline under normoxic and hypoxic (1% O(2)) conditions and analyzed for metabolic fate." | 7.74 | Biodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats. ( Bansal, A; Degrado, TR; Hara, T; Harris, RA; Shuyan, W, 2008) |
| "To examine the relationship between apparent diffusion coefficients (ADC) from diffusion weighted imaging (DWI) and choline levels from proton magnetic resonance spectroscopic imaging (MRSI) in newly diagnosed Grade II and IV gliomas within distinct anatomic regions." | 7.74 | Relationship between choline and apparent diffusion coefficient in patients with gliomas. ( Cha, S; Chang, SM; Crawford, FW; Khayal, IS; Lamborn, KR; McKnight, TR; Nelson, SJ; Saraswathy, S, 2008) |
| " The aim of this study was to assess the metabolic activity of gliomas using (11)C-methionine (MET), [(18)F] fluorodeoxyglucose (FDG), and (11)C-choline (CHO) PET and to explore the correlation between the metabolic activity and histopathologic features." | 7.74 | Metabolic assessment of gliomas using 11C-methionine, [18F] fluorodeoxyglucose, and 11C-choline positron-emission tomography. ( Iwama, T; Kato, T; Maruyama, T; Miwa, K; Muragaki, Y; Nakayama, N; Okumura, A; Shinoda, J; Yano, H; Yoshimura, S, 2008) |
| "The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas." | 7.73 | Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005) |
| "The concentrations of endogenous amino acids and choline in the extracellular fluid of human cerebral gliomas have been measured, for the first time, by in vivo microdialysis." | 7.72 | Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study. ( Ballini, C; Bianchi, L; Bricolo, A; De Micheli, E; Della Corte, L; Fattori, M; Pedata, F; Tipton, KF; Venturi, C, 2004) |
| " The purpose of this study was to investigate the correlation between the semiquantitative choline-containing compound level (Cho value) measured by MR spectroscopy and the Ki-67 labeling index in gliomas." | 7.70 | Correlation between choline level measured by proton MR spectroscopy and Ki-67 labeling index in gliomas. ( Kumabe, T; Shimizu, H; Shirane, R; Yoshimoto, T, 2000) |
| " Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220." | 7.69 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ( Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J, 1997) |
| "Palytoxin-induced whole-cell and single channel currents were recorded in mouse neuroblastoma cells." | 7.68 | Characterization of palytoxin-induced channels in mouse neuroblastoma cells. ( Dubois, JM; Rouzaire-Dubois, B, 1990) |
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 7.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| "The neuroblastoma x glioma hybrid clone NG108-15 is able to release acetylcholine upon depolarization and form cholinergic neuromuscular synapses in culture." | 7.66 | Choline uptake by the neuroblastoma x glioma hybrid, NG108-15. ( McGee, R, 1980) |
| "Human glioma cells (138MG) have a low-affinity uptake system for choline (Km = 20 microM; Vmax = 56 pmol/min/10(6) cells)." | 7.66 | Uptake and release of choline in cultures of human glioma cells. ( Walum, E, 1981) |
| "Gliomas are characterized by an inherent diffuse and irregular morphology that prevents defining a boundary between tumor and healthy tissue, both in imaging assessment and surgical field." | 5.72 | Multiple and Diffuse Gliomas by 18F-Fluorocholine PET/CT: Two Sides of the Same Coin. ( Bosque, JJ; García Vicente, AM; Pérez-Beteta, J; Pérez-García, VM; Soriano Castrejón, ÁM, 2022) |
| "Gliomas are characterized by intratumoral histological heterogeneity, coexisting foci of low and high grade." | 5.56 | Low-Grade Versus High-Grade Glioma… That Is the Question. 18F-Fluorocholine PET in the Detection of Anaplastic Focus. ( Borrás Moreno, JM; Cordero García, JM; García Vicente, AM; López Menéndez, C; Soriano Castrejón, A, 2020) |
| "High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome." | 5.46 | 18F-Fluorocholine PET/CT, Brain MRI, and 5-Aminolevulinic Acid for the Assessment of Tumor Resection in High-Grade Glioma. ( Borrás Moreno, JM; García Vicente, AM; Jiménez Aragón, F; Jiménez Londoño, GA; Villena Martín, M, 2017) |
| "The follow-up of treated low-grade glioma (LGG) requires the evaluation of subtle clinical changes and MRI results." | 5.42 | ¹⁸F-Fluorocholine PET/CT as a complementary tool in the follow-up of low-grade glioma: diagnostic accuracy and clinical utility. ( Chamorro Santos, CE; Gómez-Río, M; Lardelli-Claret, P; Llamas-Elvira, JM; Luque Caro, R; Olivares Granados, G; Rodríguez-Fernández, A; Santiago Chinchilla, A; Testart Dardel, N; Zurita Herrera, M, 2015) |
| "Choline is an essential nutrient necessary for synthesis of membrane phospholipids, cell signalling molecules and acetylcholine." | 5.35 | Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake. ( Dolezal, V; Dove, R; Lisá, V; Machová, E; Meunier, FM; Newcombe, J; O'Regan, S; Prentice, J, 2009) |
| "F98 gliomas were induced in 26 rats." | 5.33 | Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat. ( Biollaz, G; Buck, A; Goepfert, K; Lutz, A; Pahnke, J; Spaeth, N; Treyer, V; Weber, B; Westera, G; Wyss, MT, 2006) |
| "To study the association of metabolic features of F-fluorocholine in gliomas with histopathological and molecular parameters, progression-free survival (PFS) and overall survival (OS)." | 5.30 | 18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas. ( Amo-Salas, M; Barbella, R; Borrás Moreno, JM; García Vicente, AM; Klein Zampaña, CJ; Mollejo Villanueva, M; Pena Pardo, FJ; Pérez-Beteta, J; Pérez-García, VM; Sandoval Valencia, H; Soriano Castrejón, ÁM; Villena Martín, M, 2019) |
| "Pediatric brain gliomas are not always amenable for complete surgical excision, therefore adjuvant treatment for a large tumor mass is often required." | 5.30 | Variation of post-treatment H-MRSI choline intensity in pediatric gliomas. ( Alger, J; Gupta, RK; Lazareff, JA, 1999) |
| "We explored the clinical values of (11)C-choline ((11)C-CHO) PET in optimization of target volume delineation and treatment regimens in postoperative radiotherapy for brain gliomas." | 5.16 | 11C-CHO PET in optimization of target volume delineation and treatment regimens in postoperative radiotherapy for brain gliomas. ( Chang, SM; Fang, HH; Jia, HW; Li, FM; Liang, YK; Nie, Q; Wang, RM; Yang, P; Zhang, J; Zhao, WR; Zhu, Q, 2012) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 5.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "This meta-analysis indicated 11C-choline has high diagnostic accuracy for the identification of tumor relapse from radiation induced necrosis in gliomas." | 4.98 | Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis. ( Chen, G; Gao, L; Li, T; Xu, W; Zheng, J, 2018) |
| " There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids." | 4.89 | Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013) |
| "Twenty-six patients (mean age 16 years, range 8-22 years) with suspected glioma disease progression were evaluated with 18 F-choline PET/MRI." | 4.31 | Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults. ( Al-Khayfawee, A; Bomanji, J; Cockle, JV; Ferrazzoli, V; Fraioli, F; Hyare, H; Shankar, A; Tang, C, 2023) |
| "The aim of this study was to assess the prognostic performance of postoperative 18F-fluorocholine PET/CT in patients with high-grade glioma (HGG)." | 4.12 | Prognostic Potential of Postoperative 18F-Fluorocholine PET/CT in Patients With High-Grade Glioma. Clinical Validation of FuMeGA Postoperative PET Criteria. ( Amo-Salas, M; García Vicente, AM; López Menéndez, C; Pena Pardo, FJ; Pérez-Beteta, J; Soriano Castrejón, ÁM; Villena Martín, M, 2022) |
| "Patients with a previous gross total resection of glioma and the first suspicious or doubtful for recurrence MRI were prospectively included and subjected to 18 F-fluorocholine PET/CT." | 4.12 | Early Recurrence Detection of Glioma Using 18 F-Fluorocholine PET/CT : GliReDe Pilot Study. ( Amo-Salas, M; García Vicente, AM; Lozano Setien, E; Sandoval Valencia, H; Soriano Castrejón, ÁM, 2022) |
| "To investigate the diagnostic accuracy of O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary low-grade gliomas (LGG)." | 4.02 | 18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study. ( Baučić, M; Golubić, AT; Hodolič, M; Huić, D; Mišir Krpan, A; Mrak, G; Nemir, J; Žuvić, M, 2021) |
| "The aim of this study was to investigate the quantitative 18F-fluoroethylcholine (CHO) PET characteristics for differentiating lower-grade glioma (LGG) from glioblastoma (GBM)." | 4.02 | Quantitative Features From CHO PET Distinguish the WHO Grades of Primary Diffuse Glioma. ( Chen, W; Cheng, X; Jiang, C; Kong, Z; Liu, D; Ma, W; Wang, Y, 2021) |
| " These methods were evaluated for segmentation of volumetric MRSI studies of gliomas using maps of the choline to N-acetylaspartate ratio, and a qualitative comparison of lesion volumes carried out." | 3.91 | Lesion segmentation for MR spectroscopic imaging using the convolution difference method. ( Maudsley, AA, 2019) |
| "Ischemic complications after resection of high-grade glioma are frequent and may constitute potential cause of false-positive results in postsurgical evaluation using F-fluorocholine PET/CT." | 3.91 | Ischemic Complications After High-Grade Glioma Resection Could Interfere With Residual Tumor Detection With 18F-Fluorocholine PET/CT. ( García Vicente, AM; Martinez Madrigal, MM; Pena Pardo, FJ; Rodriguez Muñoz, MJ; Soriano Castrejón, A, 2019) |
| "Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas." | 3.81 | Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas. ( Kelekis, N; Kokakis, I; Kouloulias, V; Kouvaris, JR; Kyrgias, G; Mosa, E; Papathanasiou, M; Pissakas, G; Pistevou-Gombaki, K; Tolia, M; Tsoukalas, N; Verganelakis, D, 2015) |
| "The aim of this study is to assess the different metabolic activities characteristic of glioma recurrence and radiation necrosis (RN) and to explore the diagnostic accuracy for differentiation of the two conditions using (11)C-methionine (MET), (11)C-choline (CHO), and (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)." | 3.80 | Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis. ( Asano, Y; Iwama, T; Miwa, K; Nomura, Y; Shinoda, J; Takenaka, S; Yano, H; Yonezawa, S, 2014) |
| "The aim of the present study is to evaluate the role of (11)C-choline positron emission tomography/computed tomography (PET/CT) in detecting tumor recurrence and predicting survival in post-treatment patients with high-grade gliomas." | 3.80 | (11)C-choline PET/CT tumor recurrence detection and survival prediction in post-treatment patients with high-grade gliomas. ( Hu, X; Li, W; Ma, L; Sun, J; Wang, S; Wang, X, 2014) |
| "There is significant elevation of the choline (Cho) /creatine (Cr) ratio, Cho peak and depression of the N-acetylaspartate (NAA) peak in gliomas." | 3.78 | Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas. ( Shang, HB; Zhang, WF; Zhao, WG, 2012) |
| " The aim of this work is to evaluate whether regional cerebral blood volume (rCBV), as well as choline (Cho), N-acetyl-aspartate (NAA) and myo-inositol (mIns) concentrations differ between tumefactive lesions and World Health Organization (WHO) grade II-III gliomas." | 3.77 | Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. ( Blasel, S; Hattingen, E; Jansen, V; Mueller, K; Pfeilschifter, W; Zanella, F, 2011) |
| "To study choline metabolism in biopsies from nonenhancing Grade 2 (AS2) and Grade 3 (AS3) astrocytomas to determine whether (1) phosphocholine (PC) dominates in AS3, and (2) PC is associated with proliferation or angiogenesis." | 3.77 | Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma. ( Berger, MS; Chang, SM; Chiu, KS; Chu, PW; Cloyd, CP; McKnight, TR; Phillips, JJ; Smith, KJ, 2011) |
| "This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)." | 3.77 | Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011) |
| "Our purpose was to investigate whether in vivo proton magnetic resonance spectroscopic imaging, using normalized concentrations of total choline (tCho) and total creatine (tCr), can differentiate between WHO grade I pilocytic astrocytoma (PA) and diffuse, fibrillary WHO grade II astrocytoma (DA) in children." | 3.76 | Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas. ( Franz, K; Hattingen, E; Kieslich, M; Lehrbecher, T; Pilatus, U; Porto, L, 2010) |
| "The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ((1)H-MRS)." | 3.75 | Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel (1)H-MRS at 1.5 T. ( Chernov, MF; Hori, T; Iseki, H; Kubo, O; Maruyama, T; Muragaki, Y; Nakamura, R; Ono, Y; Takakura, K; Usukura, M; Yoshida, S, 2009) |
| "PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy." | 3.74 | Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy. ( Ağildere, AM; Atalay, B; Elhan, AH; Geyik, E; Ozen, O; Yerli, H, 2007) |
| " The aim of this study was to determine uptake of the (18)F-labeled PET tracers (18)F-fluorocholine (N,N-dimethyl-N-(18)F-fluoromethyl-2-hydroxyethylammonium), (18)F-fluoro-ethyl-l-tyrosine (FET), and (18)F-FDG in C6 gliomas of the rat and to correlate it with uptake of the anti-extra domain B antibody (131)I-SIP(L19) as a marker of neoangiogenesis." | 3.74 | Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis. ( Alessi, P; Biollaz, G; Buck, A; Neri, D; Pahnke, J; Spaeth, N; Trachsel, E; Treyer, V; Weber, B; Wyss, MT, 2007) |
| "Diffusion tensor imaging and multiple voxel magnetic resonance spectroscopy were performed in the MRI follow-up of a patient with a glioma treated with temozolomide chemotherapy." | 3.74 | Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy. ( Enting, RH; Heesters, MA; Irwan, R; Meiners, LC; Oudkerk, M; Potze, JH; Sijens, PE; van der Graaf, WT, 2007) |
| "9L glioma cells were incubated with [(18)F]FCH and [(14)C]choline under normoxic and hypoxic (1% O(2)) conditions and analyzed for metabolic fate." | 3.74 | Biodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats. ( Bansal, A; Degrado, TR; Hara, T; Harris, RA; Shuyan, W, 2008) |
| "To examine the relationship between apparent diffusion coefficients (ADC) from diffusion weighted imaging (DWI) and choline levels from proton magnetic resonance spectroscopic imaging (MRSI) in newly diagnosed Grade II and IV gliomas within distinct anatomic regions." | 3.74 | Relationship between choline and apparent diffusion coefficient in patients with gliomas. ( Cha, S; Chang, SM; Crawford, FW; Khayal, IS; Lamborn, KR; McKnight, TR; Nelson, SJ; Saraswathy, S, 2008) |
| " The aim of this study was to assess the metabolic activity of gliomas using (11)C-methionine (MET), [(18)F] fluorodeoxyglucose (FDG), and (11)C-choline (CHO) PET and to explore the correlation between the metabolic activity and histopathologic features." | 3.74 | Metabolic assessment of gliomas using 11C-methionine, [18F] fluorodeoxyglucose, and 11C-choline positron-emission tomography. ( Iwama, T; Kato, T; Maruyama, T; Miwa, K; Muragaki, Y; Nakayama, N; Okumura, A; Shinoda, J; Yano, H; Yoshimura, S, 2008) |
| "The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas." | 3.73 | Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005) |
| "In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)." | 3.73 | In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005) |
| "Diffusion tensor imaging (DTI) and MR spectroscopy are noninvasive, quantitative tools for the preoperative assessment of gliomas with which the quantitative parameter fractional anisotropy (FA) and the concentration of neurometabolites N-acetylaspartate (NAA), choline (Cho), creatine (Cr) of the brain can be determined." | 3.73 | Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. ( Ding, XQ; Fiehler, J; Goebell, E; Hagel, C; Heese, O; Kucinski, T; Nietz, S; Paustenbach, S; Westphal, M; Zeumer, H, 2006) |
| "The concentrations of endogenous amino acids and choline in the extracellular fluid of human cerebral gliomas have been measured, for the first time, by in vivo microdialysis." | 3.72 | Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study. ( Ballini, C; Bianchi, L; Bricolo, A; De Micheli, E; Della Corte, L; Fattori, M; Pedata, F; Tipton, KF; Venturi, C, 2004) |
| " The concentration of taurine (Tau) in medulloblastomas was 29." | 3.72 | In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004) |
| " The concentration of taurine (Tau) in medulloblastomas was 29." | 3.72 | In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004) |
| "Data obtained preoperatively from three-dimensional (3D)/proton magnetic resonance (MR) spectroscopy were compared with the results of histopathological assays of tissue biopsies obtained during surgery to verify the sensitivity and specificity of a choline-containing compound-N-acetylaspartate index (CNI) used to distinguish tumor from nontumorous tissue within T2-hyperintense and contrast-enhancing lesions of patients with untreated gliomas." | 3.71 | Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. ( Berger, MS; Dillon, WP; Graves, EE; Lu, Y; McDermott, MW; McKnight, TR; Nelson, SJ; Pirzkall, A; Vigneron, DB; von dem Bussche, MH, 2002) |
| " MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis." | 3.71 | [Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002) |
| " Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA." | 3.71 | Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. ( Herminghaus, S; Krings, T; Lanfermann, H; Marquardt, G; Möller-Hartmann, W; Pilatus, U; Zanella, FE, 2002) |
| "The authors sought to compare 1H magnetic resonance spectroscopy (MRS) spectra from extracts of low-grade and high-grade gliomas, especially with respect to the signals of choline-containing compounds." | 3.70 | Characterization of choline compounds with in vitro 1H magnetic resonance spectroscopy for the discrimination of primary brain tumors. ( Berry, I; Breil, S; Delisle, MB; Gilard, V; Malet-Martino, M; Manelfe, C; Ranjeva, JP; Sabatier, J; Terral, C; Tremoulet, M, 1999) |
| " The purpose of this study was to investigate the correlation between the semiquantitative choline-containing compound level (Cho value) measured by MR spectroscopy and the Ki-67 labeling index in gliomas." | 3.70 | Correlation between choline level measured by proton MR spectroscopy and Ki-67 labeling index in gliomas. ( Kumabe, T; Shimizu, H; Shirane, R; Yoshimoto, T, 2000) |
| " All high-grade gliomas (n = 37) showed high choline and low or absent N-acetyl-L-aspartate and creatine along with lipid and/or lactate, whereas low-grade gliomas (n = 23) were characterized by low N-acetyl-aspartate and creatine and high choline and presence of only lactate." | 3.69 | Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995) |
| " The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4." | 3.69 | Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy. ( Bandou, K; Harada, M; Kannuki, S; Miyoshi, H; Nishitani, H; Tanouchi, M, 1995) |
| "(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas." | 3.69 | Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995) |
| " We used proton nuclear magnetic resonance spectroscopy to detect the presence of simple metabolites (such as lactic acid, creatine/phosphocreatine, N-acetyl aspartate, and the "choline" pool) in extracts of a human glioma grown subcutaneously in athymic ("nu/nu") mice." | 3.69 | Effects of therapy on the 1H NMR spectrum of a human glioma line. ( Cazzaniga, S; Charles, HC; Schold, SC; Sostman, HD, 1994) |
| "A rat glioma cell line (C6) was incubated with C-14 choline; the time course of uptake and metabolism was determined in vitro." | 3.69 | Brain tumors: detection with C-11 choline PET. ( Fujii, K; Haisa, T; Hara, T; Kondo, T; Kosaka, N; Mitsui, I; Nishijima, M; Shinoura, N; Yamamoto, H, 1997) |
| " In this study, we describe the effect of ethanol on the incorporation of radioactive serine, choline and ethanolamine into their respective phospholipids in a neuroblastoma x glioma hybrid cell line (NG 108-15)." | 3.69 | Ethanol potentiates the uptake of [14C]serine into phosphatidylserine by base-exchange reaction in NG 108-15 cells. ( Alling, C; Gustavsson, L; Rodríguez, FD, 1996) |
| " Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220." | 3.69 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ( Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J, 1997) |
| " Oligodendrogliomas had higher choline levels than astrocytomas." | 3.68 | [1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia]. ( Felber, SR, 1993) |
| "Palytoxin-induced whole-cell and single channel currents were recorded in mouse neuroblastoma cells." | 3.68 | Characterization of palytoxin-induced channels in mouse neuroblastoma cells. ( Dubois, JM; Rouzaire-Dubois, B, 1990) |
| "Differences between the influences of phorbol esters (such as 4 beta-12-O-tetradecanoylphorbol 13-acetate) and of fatty acids (such as oleic acid) on the synthesis and turnover of phosphatidylcholine (PtdCho) and other phospholipids have been studied in glioma (C6), neuroblastoma (N1E-115), and hybrid (NG108-15) cells in culture using [methyl-3H]choline, [32P]Pi, [1,2-14C]ethanolamine, or 1-14C-labeled fatty acids as lipid precursors." | 3.67 | Alterations of phospholipid metabolism by phorbol esters and fatty acids occur by different intracellular mechanisms in cultured glioma, neuroblastoma, and hybrid cells. ( Byers, DM; Cook, HW; Palmer, FB; Spence, MW, 1989) |
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 3.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| "The neuroblastoma x glioma hybrid clone NG108-15 is able to release acetylcholine upon depolarization and form cholinergic neuromuscular synapses in culture." | 3.66 | Choline uptake by the neuroblastoma x glioma hybrid, NG108-15. ( McGee, R, 1980) |
| "Human glioma cells (138MG) have a low-affinity uptake system for choline (Km = 20 microM; Vmax = 56 pmol/min/10(6) cells)." | 3.66 | Uptake and release of choline in cultures of human glioma cells. ( Walum, E, 1981) |
| "Malignant brain tumors are one of the most lethal cancers." | 2.53 | The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors. ( Castro, MG; Lowenstein, PR, 2016) |
| "11C-choline has been reported as a suitable tracer for neuroimaging application." | 2.52 | Clinical applications of choline PET/CT in brain tumors. ( Ciarmiello, A; Gaeta, MC; Giovannini, E; Lazzeri, P; Milano, A, 2015) |
| "Gliomas are characterized by an inherent diffuse and irregular morphology that prevents defining a boundary between tumor and healthy tissue, both in imaging assessment and surgical field." | 1.72 | Multiple and Diffuse Gliomas by 18F-Fluorocholine PET/CT: Two Sides of the Same Coin. ( Bosque, JJ; García Vicente, AM; Pérez-Beteta, J; Pérez-García, VM; Soriano Castrejón, ÁM, 2022) |
| "Chordoid gliomas are extremely rare entities, which are generally considered occurring exclusively in the third ventricle." | 1.56 | Chordoid glioma: an entity occurring not exclusively in the third ventricle. ( Du, J; Fang, J; Li, G; Wang, S; Xu, Y; Yang, B; Yang, C, 2020) |
| "Gliomas are characterized by intratumoral histological heterogeneity, coexisting foci of low and high grade." | 1.56 | Low-Grade Versus High-Grade Glioma… That Is the Question. 18F-Fluorocholine PET in the Detection of Anaplastic Focus. ( Borrás Moreno, JM; Cordero García, JM; García Vicente, AM; López Menéndez, C; Soriano Castrejón, A, 2020) |
| "High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome." | 1.46 | 18F-Fluorocholine PET/CT, Brain MRI, and 5-Aminolevulinic Acid for the Assessment of Tumor Resection in High-Grade Glioma. ( Borrás Moreno, JM; García Vicente, AM; Jiménez Aragón, F; Jiménez Londoño, GA; Villena Martín, M, 2017) |
| "Glioma is one of the most common types of brain tumors." | 1.46 | Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy. ( Li, F; Li, H; Shi, W; Xu, Y; Yi, C; Zeng, Q, 2017) |
| "Glioma is the most common type of the primary CNS tumor." | 1.43 | Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro. ( Cui, Y; Li, FY; Li, HX; Shi, WQ; Wang, JZ; Xu, YJ; Zeng, QS, 2016) |
| "The follow-up of treated low-grade glioma (LGG) requires the evaluation of subtle clinical changes and MRI results." | 1.42 | ¹⁸F-Fluorocholine PET/CT as a complementary tool in the follow-up of low-grade glioma: diagnostic accuracy and clinical utility. ( Chamorro Santos, CE; Gómez-Río, M; Lardelli-Claret, P; Llamas-Elvira, JM; Luque Caro, R; Olivares Granados, G; Rodríguez-Fernández, A; Santiago Chinchilla, A; Testart Dardel, N; Zurita Herrera, M, 2015) |
| "Primary brain tumors (PBT), in particular gliomas, are among the most difficult neoplasms to treat, necessitating good quality imaging to guide clinicians at many junctures." | 1.37 | Promising role of [18F] fluorocholine PET/CT vs [18F] fluorodeoxyglucose PET/CT in primary brain tumors-early experience. ( Lam, WW; Ng, DC; Ong, SC; See, SJ; Wong, WY; Yu, SW, 2011) |
| "Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult." | 1.37 | Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011) |
| "Choline is an essential nutrient necessary for synthesis of membrane phospholipids, cell signalling molecules and acetylcholine." | 1.35 | Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake. ( Dolezal, V; Dove, R; Lisá, V; Machová, E; Meunier, FM; Newcombe, J; O'Regan, S; Prentice, J, 2009) |
| "Using discriminant analysis, this study found that MR spectroscopy in combination with ADC ratio, rather than ADC value, can improve the ability to differentiate recurrent glioma and radiation injury." | 1.34 | Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. ( Feng, DC; Li, CF; Liu, H; Zeng, QS; Zhen, JH, 2007) |
| "F98 gliomas were induced in 26 rats." | 1.33 | Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat. ( Biollaz, G; Buck, A; Goepfert, K; Lutz, A; Pahnke, J; Spaeth, N; Treyer, V; Weber, B; Westera, G; Wyss, MT, 2006) |
| "Ten patients with untreated gliomas were examined on a 1." | 1.32 | Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas. ( Buslei, R; Fahlbusch, R; Ganslandt, O; Gruber, S; Moser, E; Nimsky, C; Stadlbauer, A, 2004) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods." | 1.31 | Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001) |
| "High-grade brain tumors are known to have a high rate of glucose (Glc) consumption." | 1.31 | High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001) |
| "First, it allows to distinguish brain tumors from abscesses." | 1.31 | [Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis]. ( Berry, I; Ibarrola, D; Malet-Martino, M; Sabatier, J, 2001) |
| "Seventeen brain tumors were measured by 1H-CSI (chemical shift imaging) in a 1." | 1.30 | Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method. ( Furuya, S; Ide, M; Kizu, O; Maeda, T; Morishita, H; Naruse, S; Ueda, S, 1997) |
| "Pediatric brain gliomas are not always amenable for complete surgical excision, therefore adjuvant treatment for a large tumor mass is often required." | 1.30 | Variation of post-treatment H-MRSI choline intensity in pediatric gliomas. ( Alger, J; Gupta, RK; Lazareff, JA, 1999) |
| "Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas." | 1.29 | Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. ( Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL, 1993) |
| "Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values." | 1.29 | Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996) |
| "Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy." | 1.29 | Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives. ( Calabrese, G; Falini, A; Lipari, S; Losa, M; Origgi, D; Scotti, G; Triulzi, F, 1996) |
| " The dose-response curve for choline generation and DNA synthesis were comparable." | 1.28 | Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction. ( Nakashima, T; Nozawa, Y; Okano, Y; Sakai, N; Yamada, H; Zhang, W, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (7.92) | 18.7374 |
| 1990's | 38 (15.83) | 18.2507 |
| 2000's | 87 (36.25) | 29.6817 |
| 2010's | 77 (32.08) | 24.3611 |
| 2020's | 19 (7.92) | 2.80 |
| Authors | Studies |
|---|---|
| Mišir Krpan, A | 1 |
| Hodolič, M | 1 |
| Golubić, AT | 1 |
| Baučić, M | 1 |
| Nemir, J | 1 |
| Mrak, G | 1 |
| Žuvić, M | 1 |
| Huić, D | 1 |
| Rudnay, M | 1 |
| Waczulikova, I | 1 |
| Bullova, A | 1 |
| Rjaskova, G | 1 |
| Chorvath, M | 1 |
| Jezberova, M | 1 |
| Lehotska, V | 1 |
| Yang, C | 2 |
| Wu, Y | 1 |
| Wang, L | 1 |
| Li, S | 1 |
| Zhou, J | 1 |
| Tan, Y | 1 |
| Song, J | 1 |
| Xing, H | 1 |
| Yi, K | 1 |
| Zhan, Q | 1 |
| Zhao, J | 1 |
| Wang, Q | 2 |
| Yuan, X | 1 |
| Kang, C | 1 |
| García Vicente, AM | 8 |
| Pena Pardo, FJ | 4 |
| Amo-Salas, M | 3 |
| Villena Martín, M | 4 |
| López Menéndez, C | 2 |
| Soriano Castrejón, ÁM | 4 |
| Pérez-Beteta, J | 3 |
| Wang, MH | 1 |
| Roa, W | 1 |
| Wachowicz, K | 1 |
| Yahya, A | 1 |
| Murtha, A | 1 |
| Amanie, J | 1 |
| Chainey, J | 1 |
| Quon, H | 1 |
| Ghosh, S | 1 |
| Patel, S | 1 |
| Bosque, JJ | 1 |
| Pérez-García, VM | 2 |
| Sandoval Valencia, H | 3 |
| Lozano Setien, E | 2 |
| Ferrazzoli, V | 3 |
| Shankar, A | 3 |
| Cockle, JV | 3 |
| Tang, C | 3 |
| Al-Khayfawee, A | 3 |
| Bomanji, J | 3 |
| Fraioli, F | 3 |
| Hyare, H | 3 |
| Tran, D | 3 |
| Nguyen, DH | 3 |
| Nguyen, HK | 3 |
| Nguyen-Thanh, VA | 3 |
| Dong-Van, H | 3 |
| Nguyen, MD | 3 |
| De Stefano, FA | 1 |
| Morell, AA | 1 |
| Smith, G | 1 |
| Warner, T | 1 |
| Soldozy, S | 1 |
| Elarjani, T | 1 |
| Eichberg, DG | 1 |
| Luther, E | 1 |
| Komotar, RJ | 1 |
| Sheng, Y | 1 |
| Yin, D | 1 |
| Zeng, Q | 5 |
| Yang, B | 1 |
| Du, J | 1 |
| Fang, J | 1 |
| Li, G | 1 |
| Wang, S | 3 |
| Xu, Y | 3 |
| Goryawala, M | 1 |
| Saraf-Lavi, E | 1 |
| Nagornaya, N | 1 |
| Heros, D | 1 |
| Komotar, R | 1 |
| Maudsley, AA | 2 |
| Fujita, Y | 1 |
| Kohta, M | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Hashiguchi, M | 1 |
| Nagashima, H | 1 |
| Kyotani, K | 1 |
| Nakai, T | 1 |
| Ito, T | 2 |
| Kohmura, E | 1 |
| Wang, AP | 1 |
| Suryavanshi, T | 1 |
| Marcucci, M | 1 |
| Fong, C | 1 |
| Whitton, AC | 1 |
| Reddy, KKV | 1 |
| Cordero García, JM | 1 |
| Borrás Moreno, JM | 3 |
| Soriano Castrejón, A | 2 |
| Kong, Z | 2 |
| Jiang, C | 3 |
| Liu, D | 2 |
| Chen, W | 1 |
| Ma, W | 2 |
| Cheng, X | 2 |
| Wang, Y | 4 |
| Zhang, Y | 2 |
| Liu, P | 1 |
| Shi, Y | 1 |
| Zhao, D | 1 |
| Jiménez Aragón, F | 1 |
| Jiménez Londoño, GA | 1 |
| Ditter, P | 1 |
| Hattingen, E | 9 |
| Liu, Z | 1 |
| Zhang, J | 4 |
| Berrington, A | 1 |
| Voets, NL | 1 |
| Larkin, SJ | 1 |
| de Pennington, N | 1 |
| Mccullagh, J | 1 |
| Stacey, R | 1 |
| Schofield, CJ | 1 |
| Jezzard, P | 1 |
| Clare, S | 1 |
| Cadoux-Hudson, T | 1 |
| Plaha, P | 1 |
| Ansorge, O | 1 |
| Emir, UE | 1 |
| Gao, W | 1 |
| Wang, X | 3 |
| Li, F | 4 |
| Shi, W | 3 |
| Li, H | 3 |
| Pedrosa de Barros, N | 1 |
| Meier, R | 1 |
| Pletscher, M | 1 |
| Stettler, S | 1 |
| Knecht, U | 1 |
| Herrmann, E | 1 |
| Schucht, P | 1 |
| Reyes, M | 1 |
| Gralla, J | 1 |
| Wiest, R | 1 |
| Slotboom, J | 1 |
| Gao, L | 1 |
| Xu, W | 1 |
| Li, T | 1 |
| Zheng, J | 1 |
| Chen, G | 1 |
| Rodriguez Muñoz, MJ | 1 |
| Martinez Madrigal, MM | 1 |
| Chawla, S | 1 |
| Lee, SC | 1 |
| Mohan, S | 1 |
| Nasrallah, M | 1 |
| Vossough, A | 1 |
| Krejza, J | 1 |
| Melhem, ER | 1 |
| Nabavizadeh, SA | 1 |
| Mollejo Villanueva, M | 1 |
| Barbella, R | 1 |
| Klein Zampaña, CJ | 1 |
| Li, J | 2 |
| Huang, S | 1 |
| Shao, K | 1 |
| Liu, Y | 1 |
| An, S | 2 |
| Kuang, Y | 1 |
| Guo, Y | 2 |
| Ma, H | 2 |
| Balos, DR | 1 |
| Gavrilović, S | 2 |
| Lavrnić, S | 2 |
| Vasić, B | 1 |
| Macvanski, M | 2 |
| Damjanović, D | 2 |
| Opinćal, TS | 1 |
| Roder, C | 1 |
| Skardelly, M | 1 |
| Ramina, KF | 1 |
| Beschorner, R | 1 |
| Honneger, J | 1 |
| Nägele, T | 1 |
| Tatagiba, MS | 1 |
| Ernemann, U | 1 |
| Bisdas, S | 1 |
| García-Álvarez, I | 1 |
| Garrido, L | 1 |
| Romero-Ramírez, L | 1 |
| Nieto-Sampedro, M | 1 |
| Fernández-Mayoralas, A | 1 |
| Campos-Olivas, R | 1 |
| Takenaka, S | 2 |
| Asano, Y | 2 |
| Shinoda, J | 3 |
| Nomura, Y | 1 |
| Yonezawa, S | 1 |
| Miwa, K | 3 |
| Yano, H | 2 |
| Iwama, T | 3 |
| Novak, J | 1 |
| Wilson, M | 2 |
| Macpherson, L | 1 |
| Arvanitis, TN | 2 |
| Davies, NP | 2 |
| Peet, AC | 2 |
| Raschke, F | 1 |
| Jones, TL | 1 |
| Barrick, TR | 1 |
| Howe, FA | 1 |
| Madan, A | 1 |
| Ganji, SK | 2 |
| An, Z | 1 |
| Choe, KS | 1 |
| Pinho, MC | 1 |
| Bachoo, RM | 2 |
| Maher, EM | 1 |
| Choi, C | 2 |
| Babourina-Brooks, B | 1 |
| Li, W | 1 |
| Ma, L | 1 |
| Sun, J | 1 |
| Hu, X | 1 |
| Giovannini, E | 1 |
| Lazzeri, P | 1 |
| Milano, A | 1 |
| Gaeta, MC | 1 |
| Ciarmiello, A | 1 |
| Stadler, KL | 1 |
| Ober, CP | 1 |
| Feeney, DA | 1 |
| Jessen, CR | 1 |
| Yamamoto, T | 1 |
| Isobe, T | 3 |
| Akutsu, H | 1 |
| Masumoto, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206] | 12 participants (Anticipated) | Observational | 2020-12-31 | Not yet recruiting | |||
| A Prospective Study About the Validity of MRS-guided Resection on Prognosis High-grade Gliomas[NCT02795364] | 50 participants (Anticipated) | Interventional | 2016-06-30 | Not yet recruiting | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla[NCT04233788] | 55 participants (Anticipated) | Observational | 2021-09-01 | Recruiting | |||
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Study of Clinical Biomarkers in Human Health and Disease (Healthiomics)[NCT05106725] | 3,500 participants (Anticipated) | Observational | 2021-10-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for choline and Glioma
| Article | Year |
|---|---|
Unique magnetic resonance spectroscopy profile of intracranial meningiomas compared to gliomas: a systematic review.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Spectr | 2023 |
Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis.
Topics: Carbon Radioisotopes; Choline; Diagnosis, Differential; Glioma; Humans; Necrosis; Neoplasm Recurrenc | 2018 |
Clinical applications of choline PET/CT in brain tumors.
Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Glioma; Half-Life; Humans; P | 2015 |
The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade gliomas: A systematic review and meta-analysis.
Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Databases, Factual; Glioma; Hum | 2016 |
The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors.
Topics: Adenoviridae; Animals; Brain Neoplasms; Choline; Dendritic Cells; Genetic Therapy; Genetic Vectors; | 2016 |
[Corpus callosum tumor as the presenting symptom of neurofibromatosis type 1 in a patient and literature review].
Topics: Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child, Preschool; Choline; Corpus Callo | 2012 |
Potential of MR spectroscopy for assessment of glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol | 2013 |
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ | 2013 |
Imaging gliomas with positron emission tomography and single-photon emission computed tomography.
Topics: Brain; Brain Neoplasms; Choline; Fluorodeoxyglucose F18; Glioma; Methionine; Methyltyrosines; Predic | 2003 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
[PET and malignant cerebral tumors].
Topics: Brain Neoplasms; Choline; Dideoxynucleosides; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Glioma | 2006 |
Brain stem involvement in children with neurofibromatosis type 1: role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Choline; Creatine; | 1997 |
11 trials available for choline and Glioma
| Article | Year |
|---|---|
18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas.
Topics: Choline; Chromosome Deletion; Disease Progression; Female; Glioma; Humans; Isocitrate Dehydrogenase; | 2019 |
Evaluation of human glioma using in-vivo proton magnetic resonance spectroscopy combined with expression of cyclooxygenase-2: a preliminary clinical trial.
Topics: Adult; Aged; Biomarkers, Tumor; Brain; Brain Neoplasms; Choline; Creatine; Cyclooxygenase 2; Female; | 2017 |
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis | 2008 |
11C-CHO PET in optimization of target volume delineation and treatment regimens in postoperative radiotherapy for brain gliomas.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carbon Radioisotopes; Child; Choline; Female; Follow-Up St | 2012 |
The optimal timing for imaging brain tumours and other brain lesions with 18F-labelled fluoromethylcholine: a dynamic positron emission tomography study.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; | 2012 |
Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy.
Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Choline; Dacarbazin | 2004 |
Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings.
Topics: Adult; Aged; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choli | 2004 |
Contrast/Noise ratio on conventional MRI and choline/creatine ratio on proton MRI spectroscopy accurately discriminate low-grade from high-grade cerebral gliomas.
Topics: Adolescent; Adult; Aged; Algorithms; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Fe | 2006 |
Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas.
Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Pro | 2007 |
Multivoxel 3D proton MR spectroscopy in the distinction of recurrent glioma from radiation injury.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fema | 2007 |
Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Pr | 1996 |
217 other studies available for choline and Glioma
| Article | Year |
|---|---|
18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study.
Topics: Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Imaging; Pilot Projects; Positron Emiss | 2021 |
Magnetic resonance spectroscopy - its added value in brain glioma multiparametric assessment.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectro | 2021 |
Glioma-derived exosomes hijack the blood-brain barrier to facilitate nanocapsule delivery via LCN2.
Topics: Blood-Brain Barrier; Choline; Endothelial Cells; Exosomes; Glioblastoma; Glioma; Humans; Lipocalin-2 | 2022 |
Prognostic Potential of Postoperative 18F-Fluorocholine PET/CT in Patients With High-Grade Glioma. Clinical Validation of FuMeGA Postoperative PET Criteria.
Topics: Choline; Glioma; Humans; Neoplasm Recurrence, Local; Positron Emission Tomography Computed Tomograph | 2022 |
Early Metabolic Changes in 1H-MRSI Predictive for Survival in Patients With Newly Diagnosed High-grade Glioma.
Topics: Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging; Magnetic Resonance S | 2022 |
Multiple and Diffuse Gliomas by 18F-Fluorocholine PET/CT: Two Sides of the Same Coin.
Topics: Choline; Glioma; Humans; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals | 2022 |
Early Recurrence Detection of Glioma Using 18 F-Fluorocholine PET/CT : GliReDe Pilot Study.
Topics: Choline; Early Diagnosis; Glioma; Humans; Neoplasm Recurrence, Local; Pilot Projects; Positron Emiss | 2022 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Mapping glioma heterogeneity using multiparametric 18 F-choline PET/MRI in childhood and teenage-young adults.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Choline; Diffusion Magnetic Resonance Imaging; Glioma; Hu | 2023 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Using the metabolite alterations monitoring the AEG-1 expression level and cell biological behaviour of U251 cell in vitro.
Topics: Astrocytes; Choline; Gene Expression; Glioma; Humans; Lactic Acid; Oncogenes | 2023 |
Chordoid glioma: an entity occurring not exclusively in the third ventricle.
Topics: Adult; Aged; Aspartic Acid; Cerebellum; Cerebral Ventricle Neoplasms; Choline; Diffusion Magnetic Re | 2020 |
The Association between Whole-Brain MR Spectroscopy and IDH Mutation Status in Gliomas.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Isocitrate | 2020 |
Intraoperative 3-T Magnetic Resonance Spectroscopy for Detection of Proliferative Remnants of Glioma.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; M | 2020 |
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.
Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err | 2020 |
Low-Grade Versus High-Grade Glioma… That Is the Question. 18F-Fluorocholine PET in the Detection of Anaplastic Focus.
Topics: Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Imaging; Neoplasm Grading; Neovasculari | 2020 |
FuMeGA Criteria for Visual Assessment of Postoperative 18F-Fluorocholine PET in Patients With Glioma.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; Image Processing, Computer-Assisted; | 2020 |
Quantitative Features From CHO PET Distinguish the WHO Grades of Primary Diffuse Glioma.
Topics: Adult; Aged; Area Under Curve; Brain Neoplasms; Choline; Diagnosis, Differential; Female; Glioma; Hu | 2021 |
Role of traditional CHO PET parameters in distinguishing IDH, TERT and MGMT alterations in primary diffuse gliomas.
Topics: Adult; Aged; Biomarkers, Tumor; Choline; DNA Modification Methylases; DNA Repair Enzymes; Female; Gl | 2021 |
18F-Fluorocholine PET/CT, Brain MRI, and 5-Aminolevulinic Acid for the Assessment of Tumor Resection in High-Grade Glioma.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Imaging; Ma | 2017 |
[Magnetic resonance spectroscopy of brain tumors].
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging | 2017 |
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res | 2017 |
A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Female; Glioma; Glutarates; Humans; Isocitrate Dehydrogen | 2018 |
Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Proliferation; Chil | 2019 |
On the relation between MR spectroscopy features and the distance to MRI-visible solid tumor in GBM patients.
Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Healthy Volunteers; Hu | 2018 |
Lesion segmentation for MR spectroscopic imaging using the convolution difference method.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Computer Simulation; Glio | 2019 |
Ischemic Complications After High-Grade Glioma Resection Could Interfere With Residual Tumor Detection With 18F-Fluorocholine PET/CT.
Topics: Adult; Brain Ischemia; Brain Neoplasms; Choline; Diagnosis, Differential; Female; Glioma; Humans; Ma | 2019 |
Lack of choline elevation on proton magnetic resonance spectroscopy in grade I-III gliomas.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Mid | 2019 |
A choline derivate-modified nanoprobe for glioma diagnosis using MRI.
Topics: Animals; Brain Neoplasms; Choline; Contrast Media; Glioma; Image Enhancement; Magnetic Resonance Ima | 2013 |
Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diffusion | 2013 |
Spectroscopy imaging in intraoperative MR suite: tissue characterization and optimization of tumor resection.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Image | 2014 |
The effect of antitumor glycosides on glioma cells and tissues as studied by proton HR-MAS NMR spectroscopy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferati | 2013 |
Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis.
Topics: Adult; Aged; Area Under Curve; Brain; Brain Neoplasms; Carbon Isotopes; Choline; Combined Modality T | 2014 |
Clinical protocols for ³¹P MRS of the brain and their use in evaluating optic pathway gliomas in children.
Topics: Adult; Analysis of Variance; Biomarkers, Tumor; Brain; Child, Preschool; Choline; Female; Glioma; Hu | 2014 |
Delineation of gliomas using radial metabolite indexing.
Topics: Algorithms; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Diagnosis, Computer-Assisted | 2014 |
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; | 2015 |
MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment.
Topics: Adolescent; Algorithms; Biomarkers, Tumor; Body Water; Brain Neoplasms; Cerebellar Neoplasms; Child; | 2014 |
(11)C-choline PET/CT tumor recurrence detection and survival prediction in post-treatment patients with high-grade gliomas.
Topics: Adult; Aged; Brain; Brain Neoplasms; Choline; Female; Follow-Up Studies; Glioma; Humans; Magnetic Re | 2014 |
Multivoxel proton magnetic resonance spectroscopy of inflammatory and neoplastic lesions of the canine brain at 3.0 T.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, | 2014 |
Influence of echo time in quantitative proton MR spectroscopy using LCModel.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer | 2015 |
¹⁸F-Fluorocholine PET/CT as a complementary tool in the follow-up of low-grade glioma: diagnostic accuracy and clinical utility.
Topics: Adult; Brain Neoplasms; Choline; Female; Glioma; Humans; Male; Middle Aged; Multimodal Imaging; Posi | 2015 |
¹⁸F-Fluorocholine PET/CT as a complementary tool in the follow-up of low-grade glioma.
Topics: Brain Neoplasms; Choline; Female; Glioma; Humans; Male; Positron-Emission Tomography; Radiopharmaceu | 2015 |
Machine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy.
Topics: Algorithms; Artificial Intelligence; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Cre | 2015 |
Primary Central Nervous System Natural Killer Cell Lymphoma in a Chinese Woman with Atypical (11)C-Choline Positron Emission Tomography and Magnetic Resonance Spectrometry Findings.
Topics: Adult; Central Nervous System Neoplasms; Choline; Female; Fluorodeoxyglucose F18; Glioma; Humans; Ki | 2015 |
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra | 2016 |
Dynamic 1H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma.
Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Choline; Diagnosis, Differe | 2015 |
Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas.
Topics: Adult; Age Factors; Aged; Choline; Creatine; Disease-Free Survival; Female; Glioma; Humans; Magnetic | 2015 |
Choline Derivate-Modified Doxorubicin Loaded Micelle for Glioma Therapy.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Choline; Doxorubicin; Flow Cytometry; Glioma; Human | 2015 |
Comparison between magnetic resonance spectroscopy and diffusion weighted imaging in the evaluation of gliomas response after treatment.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Diffusion Magnetic Resonanc | 2015 |
Metabolic approach for tumor delineation in glioma surgery: 3D MR spectroscopy image-guided resection.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diffusion Tensor Imaging; Feasibility S | 2016 |
Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro.
Topics: Aspartic Acid; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Choline; C | 2016 |
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre | 2016 |
Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy.
Topics: Apoptosis; Astrocytes; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Choline; Creati | 2017 |
Prognostic value of choline and creatine in WHO grade II gliomas.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Disease-Free Survival; Female; Follow-Up Studies; G | 2008 |
Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Gliom | 2008 |
Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel (1)H-MRS at 1.5 T.
Topics: Adult; Brain Neoplasms; Choline; Female; Glioma; Humans; Magnetic Resonance Imaging; Magnetic Resona | 2009 |
Technetium Tc99m tetrofosmin single-photon emission CT for the assessment of glioma proliferation.
Topics: Adult; Brain Neoplasms; Carbon Radioisotopes; Choline; Female; Fluorodeoxyglucose F18; Gene Expressi | 2008 |
Bilateral thalamic glioma.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imagin | 2008 |
Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake.
Topics: Acetylcholine; Animals; Antibody Specificity; Antigens, CD; Cell Differentiation; Cell Enlargement; | 2009 |
(1)H MRSI and progression-free survival in patients with WHO grades II and III gliomas.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Disease Progression; Disease-Free Survival; Female; | 2010 |
Differential diagnosis between radiation necrosis and glioma progression using sequential proton magnetic resonance spectroscopy and methionine positron emission tomography.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Neoplasms; Carbon Radioisotopes; Choline; Diagnosi | 2009 |
MR spectroscopic evaluation of brain tissue damage after treatment for pediatric brain tumors.
Topics: Adolescent; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Ependymoma; Female; Gli | 2010 |
Diagnostic value of proton magnetic resonance spectroscopy in the noninvasive grading of solid gliomas: comparison of maximum and mean choline values.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer-Assisted; Magn | 2009 |
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr | 2010 |
MR spectroscopy for differentiation of recurrent glioma from radiation-induced changes.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast | 2009 |
The metabolic epicenter of supratentorial gliomas: a 1H-MRSI study.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Chi-Square Distribution; Cholin | 2009 |
Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; | 2010 |
Response to article "Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors".
Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc | 2010 |
Response to a letter by Paul E. Sijens.
Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc | 2010 |
Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization.
Topics: Animals; Artifacts; Biological Transport; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemica | 2010 |
Magnetic resonance spectroscopic imaging for visualization of the infiltration zone of glioma.
Topics: Adult; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Choline; Data Interpretation, Statistica | 2011 |
Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas.
Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Im | 2011 |
Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain Neoplasms; Cerebrovas | 2011 |
Biopsy targeting gliomas: do functional imaging techniques identify similar target areas?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Contras | 2010 |
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Creatine; Female; Glioma; H | 2011 |
Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1.
Topics: Brain; Choline; Glioma; Humans; Male; Neurofibromatosis 1; Optic Nerve; Positron-Emission Tomography | 2010 |
Value of 1H-magnetic resonance spectroscopy chemical shift imaging for detection of anaplastic foci in diffusely infiltrating gliomas with non-significant contrast-enhancement.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; H | 2011 |
Promising role of [18F] fluorocholine PET/CT vs [18F] fluorodeoxyglucose PET/CT in primary brain tumors-early experience.
Topics: Brain Neoplasms; Choline; Fatal Outcome; Female; Fluorine Radioisotopes; Glioblastoma; Glioma; Human | 2011 |
Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen.
Topics: Adolescent; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anti | 2011 |
Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas.
Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Diagnos | 2010 |
Heterogeneity in malignant gliomas: a magnetic resonance analysis of spatial distribution of metabolite changes and regional blood volume.
Topics: Adult; Aged; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Female; Glioma; Humans | 2011 |
pH optimization for a reliable quantification of brain tumor cell and tissue extracts with (1)H NMR: focus on choline-containing compounds and taurine.
Topics: Brain; Brain Chemistry; Brain Neoplasms; Choline; Glioma; Humans; Hydrogen-Ion Concentration; Magnet | 2011 |
Mathematical modeling of energy metabolism and hemodynamics of WHO grade II gliomas using in vivo MR data.
Topics: Adolescent; Adult; Aged; Algorithms; Brain Neoplasms; Cerebrovascular Circulation; Child; Choline; F | 2011 |
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe | 2011 |
Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma.
Topics: Adult; Astrocytoma; Biopsy; Brain Neoplasms; Cell Proliferation; Choline; Female; Glioma; Glycerylph | 2011 |
Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Brain Neoplasms; Choline; Creatine; D | 2011 |
Papillary glioneuronal tumor: unexplored entity.
Topics: Adult; Brain Neoplasms; Choline; Creatinine; Diffusion Magnetic Resonance Imaging; Female; Glioma; H | 2012 |
Glioma residual or recurrence versus radiation necrosis: accuracy of pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT compared to proton magnetic resonance spectroscopy (1H-MRS): initial results.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Follow-Up Studie | 2012 |
F-18 choline PET does not detect increased metabolism in F-18 fluoroethyltyrosine-negative low-grade gliomas.
Topics: Adult; Brain Neoplasms; Choline; False Negative Reactions; Female; Glioma; Humans; Male; Middle Aged | 2012 |
Cutoff value of choline concentration reliably reveals high-grade brain tumors among other contrast-enhancing brain lesions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Diseases; Brain Infarction; Brain Neoplasms; Centr | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.
Topics: Adolescent; Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Feasibi | 2012 |
Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Fluorodeoxy | 2012 |
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu | 2012 |
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu | 2012 |
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu | 2012 |
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu | 2012 |
Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas.
Topics: Adolescent; Adult; Aged; Anisotropy; Aspartic Acid; Brain Neoplasms; Cerebral Cortex; Child; Choline | 2012 |
Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glioma; Humans; Lactic Acid; Lip | 2002 |
Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence.
Topics: Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Spectroscopy; Pr | 2002 |
Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenografts.
Topics: Animals; Brain Neoplasms; Carbon-Sulfur Lyases; Choline; Choline Deficiency; Glioma; Homocysteine; H | 2002 |
In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience.
Topics: Adult; Astrocytoma; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Female; Gliobl | 2002 |
Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Brefeldin A; Cell Division; Cell Line; Cerami | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia | 2002 |
[Changes in 1H-MRS in glioma patients before and after irradiation: the significance of quantitative analysis of choline-containing compounds].
Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Choline; Female; Glioma; Humans; Magnetic Resonance Spectr | 2003 |
Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy.
Topics: Central Nervous System Neoplasms; Choline; Diagnosis, Differential; Glioma; Humans; Immunocompetence | 2003 |
Preoperative proton-MR spectroscopy of gliomas--correlation with quantitative nuclear morphology in surgical specimen.
Topics: Brain Neoplasms; Cell Division; Cell Nucleus; Choline; Fourier Analysis; Glioma; Humans; Immunoenzym | 2003 |
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Choline; Diffusion; Ganciclovir; Genet | 2003 |
Use of 18F-choline and 11C-choline as contrast agents in positron emission tomography imaging-guided stereotactic biopsy sampling of gliomas.
Topics: Adolescent; Adult; Aged; Biopsy; Brain Neoplasms; Choline; Contrast Media; Female; Glioma; Humans; M | 2003 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study.
Topics: Adult; Aged; Amino Acids; Brain Neoplasms; Cell Division; Choline; Extracellular Space; Female; Glio | 2004 |
1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Dose-Response Relationshi | 2004 |
[Usefulness of Cho/Cr ratio in proton MR spectroscopy for differentiating residual/recurrent glioma from non-neoplastic lesions].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Female; Glioma | 2004 |
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; C | 2004 |
Proton magnetic resonance spectroscopy-guided biopsy for cerebral glial tumors.
Topics: Adult; Aged; Biopsy; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Ki-67 Antigen; Magn | 2004 |
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
Topics: Adult; Aged; Aspartic Acid; Body Water; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr | 2004 |
Perfusion magnetic resonance imaging and magnetic resonance spectroscopy of cerebral gliomas showing imperceptible contrast enhancement on conventional magnetic resonance imaging.
Topics: Adult; Blood Volume; Brain; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Angiograph | 2004 |
Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas.
Topics: Adult; Algorithms; Aspartic Acid; Astrocytoma; Automation; Biopsy; Brain Chemistry; Brain Mapping; B | 2004 |
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin | 2005 |
Clinicopathological examination of glioma by proton magnetic resonance spectroscopy background.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioma; Humans; Lactic Acid; Magnetic Resona | 2004 |
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Child, Preschool; Cho | 2005 |
Spectroscopy and navigation.
Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Glioma; Humans; Image Processing, Comput | 2005 |
Proton magnetic resonance spectroscopic imaging integrated into image-guided surgery: correlation to standard magnetic resonance imaging and tumor cell density.
Topics: Algorithms; Aspartic Acid; Biopsy; Brain Neoplasms; Cell Count; Choline; Feasibility Studies; Glioma | 2005 |
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression | 2005 |
High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma.
Topics: Animals; Apoptosis; Biomarkers; Brain Neoplasms; Choline; Female; Genetic Therapy; Glioma; Image Int | 2005 |
Correlation between choline and MIB-1 index in human gliomas. A quantitative in proton MR spectroscopy study.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; Ki-67 Antigen; Magnetic Resonance Spe | 2005 |
The contribution of magnetic resonance spectroscopy and echoplanar perfusion-weighted MRI in the initial assessment of brain tumours.
Topics: Adolescent; Adult; Aged; Astrocytoma; Blood Volume; Brain Neoplasms; Child; Child, Preschool; Cholin | 2005 |
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic | 2005 |
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy.
Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv | 2006 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla | 2005 |
Preoperative grading of gliomas by using metabolite quantification with high-spatial-resolution proton MR spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Female; | 2006 |
Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Brain Neoplasms; Cell Line, Tumor; Choline; Fluorodeox | 2006 |
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio | 2006 |
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma; | 2006 |
Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study.
Topics: Adult; Aged; Anisotropy; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Size; Choline; Cre | 2006 |
Long-term normal-appearing brain tissue monitoring after irradiation using proton magnetic resonance spectroscopy in vivo: statistical analysis of a large group of patients.
Topics: Adult; Aged; Aspartic Acid; Blood-Brain Barrier; Brain; Brain Neoplasms; Choline; Creatine; Female; | 2006 |
Comments and controversies: magnetic resonance spectroscopy and gliomas.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; | 2006 |
Proton magnetic resonance spectroscopy in childhood brainstem lesions.
Topics: Adolescent; Amino Acids; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neop | 2007 |
Use of MR spectroscopy and functional imaging in the treatment planning of gliomas.
Topics: Brain; Brain Neoplasms; Choline; Cranial Irradiation; Creatine; Glioma; Humans; Image Processing, Co | 2007 |
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Diffusion Magn | 2007 |
Proton magnetic resonance spectroscopic imaging in the border zone of gliomas: correlation of metabolic and histological changes at low tumor infiltration--initial results.
Topics: Aspartic Acid; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; Neoplasm Invasive | 2007 |
Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imaging; | 2007 |
Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis.
Topics: Animals; Antibodies; Brain Neoplasms; Cell Line, Tumor; Choline; Fibronectins; Glioma; Male; Neovasc | 2007 |
Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Blood Flow Velocity; Brain; Brain Neoplasms; Choline | 2007 |
Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics.
Topics: Adolescent; Adult; Blood Flow Velocity; Choline; Creatine; Diagnosis, Differential; Diffusion Magnet | 2007 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; | 2007 |
Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Choline; Dacarbazine; Diffusion Magnetic Resonan | 2007 |
Biodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats.
Topics: Animals; Cell Line, Tumor; Choline; Glioma; Male; Metabolic Clearance Rate; Organ Specificity; Radio | 2008 |
Relationship between choline and apparent diffusion coefficient in patients with gliomas.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Chemistry; Brain Neoplasms; Choline; Diffusion Magnetic | 2008 |
Metabolic assessment of gliomas using 11C-methionine, [18F] fluorodeoxyglucose, and 11C-choline positron-emission tomography.
Topics: Adult; Brain Neoplasms; Carbon Radioisotopes; Choline; Female; Fluorodeoxyglucose F18; Gene Expressi | 2008 |
A diffusible factor responsible for the determination of cholinergic functions in cultured sympathetic neurons. Partial purification and characterization.
Topics: Animals; Animals, Newborn; Cell Line; Cells, Cultured; Choline; Ganglia, Sympathetic; Glioma; Kineti | 1981 |
Choline uptake by the neuroblastoma x glioma hybrid, NG108-15.
Topics: Animals; Biological Transport; Bucladesine; Cell Line; Choline; Clone Cells; Glioma; Hemicholinium 3 | 1980 |
Uptake and release of choline in cultures of human glioma cells.
Topics: Cell Line; Choline; Glioma; Humans; Tumor Cells, Cultured | 1981 |
Comparison of lipids and lipid metabolism in a human glioma cell line, its clone, and oligodendroglia.
Topics: Acetates; Acetic Acid; Cell Line; Choline; Chromatography, Thin Layer; Clone Cells; Glioma; Glycolip | 1983 |
A new capillary tube system for measuring the uptake and release of materials from cultured cells.
Topics: Acetylcholine; Animals; Biological Transport; Cell Line; Choline; Glioma; Hybrid Cells; Kinetics; Me | 1980 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea | 1995 |
Spectral editing with adiabatic pulses.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Choline; Creatine; Feasibility Studies; Gl | 1995 |
Proton magnetic resonance spectroscopy of astrocytic tumors: an in vitro study.
Topics: Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fe | 1993 |
Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Ependymoma; Glioma; Humans; Magnetic | 1995 |
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di | 1995 |
Effects of therapy on the 1H NMR spectrum of a human glioma line.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Lactates; Magnetic Resonance Spe | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells.
Topics: Animals; Carbon Isotopes; Cell Division; Choline; Ethanolamines; Glioma; Magnetic Resonance Spectros | 1994 |
Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance I | 1993 |
Quantitative proton spectroscopy and histology of a canine brain tumor model.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag | 1993 |
In vivo, ex vivo, and in vitro one- and two-dimensional nuclear magnetic resonance spectroscopy of an intracerebral glioma in rat brain: assignment of resonances.
Topics: Amino Acids; Animals; Brain; Brain Neoplasms; Choline; Fatty Acids, Nonesterified; Glioma; Lactates; | 1994 |
[1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Child; Child, Preschool; | 1993 |
Limited metabolic interaction of serine with ethanolamine and choline in the turnover of phosphatidylserine, phosphatidylethanolamine and plasmalogens in cultured glioma cells.
Topics: Animals; Carbon Radioisotopes; Choline; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamine | 1993 |
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal | 1996 |
Phorbol ester stimulation of phosphatidylcholine synthesis in four cultured neural cell lines: correlations with expression of protein kinase C isoforms.
Topics: Animals; Blotting, Northern; Blotting, Western; Choline; Gene Expression; Glioma; Humans; Isoenzymes | 1995 |
Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives.
Topics: Adenoma; Aspartic Acid; Brain Neoplasms; Choline; Craniopharyngioma; Creatinine; Glioma; Humans; Lym | 1996 |
Brain tumors: detection with C-11 choline PET.
Topics: Adult; Aged; Animals; Brain Neoplasms; Child; Choline; Female; Glioma; Humans; Male; Middle Aged; Ox | 1997 |
Ethanol potentiates the uptake of [14C]serine into phosphatidylserine by base-exchange reaction in NG 108-15 cells.
Topics: Animals; Carbon Radioisotopes; Choline; Ethanol; Ethanolamine; Ethanolamines; Glioma; Hybrid Cells; | 1996 |
Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy.
Topics: Adenoma; Adolescent; Adult; Aged; Amino Acids; Brain; Brain Neoplasms; Child; Choline; Creatine; Fem | 1997 |
Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Evaluation Studies as Topic; Glioma; Humans; Imag | 1997 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phos | 1997 |
Magnetic resonance spectroscopy guided brain tumor resection: differentiation between recurrent glioma and radiation change in two diagnostically difficult cases.
Topics: Adult; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Diagnosis, Differential; Glioma; | 1998 |
1H MR spectroscopy monitoring of changes in choline peak area and line shape after Gd-contrast administration.
Topics: Adult; Aged; Brain; Brain Neoplasms; Choline; Contrast Media; Female; Gadolinium DTPA; Glioma; Human | 1998 |
Characterization of choline compounds with in vitro 1H magnetic resonance spectroscopy for the discrimination of primary brain tumors.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; In Vitro Techniques; Magnetic Resonan | 1999 |
Ca2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line.
Topics: Calcium; Charybdotoxin; Choline; Dose-Response Relationship, Drug; Glioma; Gluconates; Humans; Intra | 1999 |
Variation of post-treatment H-MRSI choline intensity in pediatric gliomas.
Topics: Astrocytoma; Biopsy; Brain Neoplasms; Child; Child, Preschool; Choline; Follow-Up Studies; Glioma; H | 1999 |
Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Fema | 2000 |
Correlation between choline level measured by proton MR spectroscopy and Ki-67 labeling index in gliomas.
Topics: Adult; Aged; Brain Neoplasms; Cell Division; Choline; Female; Glioma; Humans; Ki-67 Antigen; Magneti | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Female; Glioma; Humans; Imaging, Three-Dimens | 2001 |
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies; | 2001 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; | 2001 |
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S | 2001 |
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr | 2001 |
[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis].
Topics: Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Energy Metabolism; | 2001 |
[1H-MR Spectroscopy of brain tumors in the course of radiation therapy: Use of fast spectroscopic imaging and single-voxel spectroscopy for diagnosing recurrence].
Topics: Adult; Aged; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Cranial Irradiation; Energy | 2002 |
Proton magnetic resonance spectroscopy of cerebral glioma after irradiation.
Topics: Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy | 2001 |
High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Bra | 2002 |
The effect of Gd-DTPA on T(1)-weighted choline signal in human brain tumours.
Topics: Brain Neoplasms; Choline; Contrast Media; Gadolinium DTPA; Glioma; Humans; Magnetic Resonance Spectr | 2002 |
Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions.
Topics: Aspartic Acid; Brain Abscess; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Diagnosis, Di | 2002 |
Counter transport of glutamine and choline in cultures of human glioma cells.
Topics: Biological Transport; Cells, Cultured; Choline; Diffusion; Glioma; Glutamine; Humans; Kinetics; Neop | 1979 |
Calcium fluxes in cultured and bulk isolated neuronal and glial cells.
Topics: Acetylcholine; Animals; Astrocytes; Brain Neoplasms; Calcium; Cells, Cultured; Choline; Glioma; Huma | 1977 |
On the uptake mechanism of choline in nerve cell cultures.
Topics: Animals; Astrocytes; Brain; Chick Embryo; Choline; Cholinesterase Inhibitors; Clone Cells; Cyanides; | 1976 |
Synapse formation between clonal neuroblastoma X glioma hybrid cells and striated muscle cells.
Topics: Action Potentials; Calcium; Cells, Cultured; Choline; Glioma; Hybrid Cells; Membrane Potentials; Mus | 1976 |
Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction.
Topics: Animals; Choline; DNA Replication; DNA, Neoplasm; Enzyme Activation; Glioma; Glycerophospholipids; K | 1992 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
Characterization of palytoxin-induced channels in mouse neuroblastoma cells.
Topics: Acrylamides; Animals; Calcium; Cell Membrane Permeability; Choline; Cnidarian Venoms; Electric Condu | 1990 |
Effects of insulin on glucose uptake in cultured cells from the central nervous system of rodent.
Topics: Animals; Calcium; Carbachol; Central Nervous System; Choline; Deoxyglucose; Glioma; Insulin; Kinetic | 1991 |
Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis by cytochalasin B in cultured glioma cells: potential regulation of biosynthesis by Ca(2+)-dependent mechanisms.
Topics: Animals; Biological Transport, Active; Calcium; Carbon Radioisotopes; Cell Line; Choline; Cytochalas | 1991 |
Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2+.
Topics: Animals; Calcium; Choline; Cytidine Diphosphate Choline; Electricity; Glioma; Permeability; Phosphat | 1991 |
Organic cations substituted for sodium are toxic to cultured rat glioma cells.
Topics: Animals; Cations; Choline; Glioma; Osmolar Concentration; Rats; Sodium; Tumor Cells, Cultured | 1990 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |
Alterations of phospholipid metabolism by phorbol esters and fatty acids occur by different intracellular mechanisms in cultured glioma, neuroblastoma, and hybrid cells.
Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Fatty Acids; Glioma; Hybrid Cells; Kinetic | 1989 |
Isolation of plasma membranes from cultured glioma cells and application to evaluation of membrane sphingomyelin turnover.
Topics: Biomarkers; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Choline; Enzymes; Glio | 1988 |
Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Choline; Chromatography, High Pressure Liqui | 1987 |
Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters.
Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glioma; Inositol; Neuroblastoma; Phorbol E | 1986 |
AF64A: an active site directed irreversible inhibitor of choline acetyltransferase.
Topics: Animals; Aziridines; Azirines; Cell Line; Choline; Choline Kinase; Choline O-Acetyltransferase; Chol | 1985 |
Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by factors contained in glioma-conditioned medium: enhancement of high-affinity choline uptake system and reduction of norepinephrine uptake system.
Topics: Acetylcholine; Adrenal Gland Neoplasms; Animals; Cell Differentiation; Choline; Cholinergic Fibers; | 1986 |
Cultured cell systems and methods for neurobiology.
Topics: Acetylcholine; Acetylcholinesterase; Acetyltransferases; Animals; Brain; Brain Neoplasms; Carbon Rad | 1974 |
The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons.
Topics: Acetylcholine; Animals; Catecholamines; Cells, Cultured; Choline; Cytarabine; Fibroblasts; Floxuridi | 1974 |
High activity of choline acetyltransferase induced in neuroblastoma x glia hybrid cells.
Topics: Acetylcholinesterase; Acetyltransferases; Animals; Cell Fusion; Cell Line; Choline; Chromosomes; Clo | 1974 |