choline has been researched along with Glioblastoma in 92 studies
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma." | 9.12 | [Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007) |
| "Glioblastomas (GBMs), the most frequent and aggressive human primary brain tumours, have altered cell metabolism, and one of the strongest indicators of malignancy is an increase in choline compounds." | 8.02 | Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. ( Benfante, R; Clementi, F; Daga, A; Di Lascio, S; Fasoli, F; Gordon, TJ; Gotti, C; McIntosh, M; Moretti, M; Pucci, S; Viani, P; Zoli, M, 2021) |
| "Positron emission tomography (PET) and PET/computed tomography (PET-CT) studies with (11)C- or (18)F-labeled choline derivatives are used for PET imaging in glioblastoma patients." | 7.80 | Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs. ( Hara, N; Inazu, M; Saiki, I; Taguchi, C; Uchino, H; Yamanaka, T; Yara, M, 2014) |
| "A new method based on hydrophilic interaction chromatography-electrospray ionisation-tandem mass spectrometry (HILIC-ESI-MS/MS) coupled to the use of a stable isotope labelled substrate was developed to study the metabolism of choline (Cho) compounds in two human glioblastoma multiform (GBM) cell lines with different responses to ionising radiation." | 7.76 | Analysis of hydrophilic and lipophilic choline compounds in radioresistant and radiosensitive glioblastoma cell lines by HILIC-ESI-MS/MS. ( Balayssac, S; Claparols, C; Desoubzdanne, D; Gilard, V; Malet-Martino, M; Martino, R; Martins-Froment, N; Tercé, F; Zedde, C, 2010) |
| "To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)." | 7.72 | Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004) |
| "Thirteen patients with recurrent glioblastoma were enrolled in RTOG 0625/ACRIN 6677, a prospective multicenter trial in which bevacizumab was used in combination with either temozolomide or irinotecan." | 5.17 | Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. ( Barboriak, DP; Bokstein, F; Boxerman, JL; Gilbert, MR; McKinstry, RC; Ratai, EM; Safriel, Y; Snyder, BS; Sorensen, AG; Zhang, Z, 2013) |
| "The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma." | 5.12 | [Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| "Glioblastomas (GBMs), the most frequent and aggressive human primary brain tumours, have altered cell metabolism, and one of the strongest indicators of malignancy is an increase in choline compounds." | 4.02 | Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. ( Benfante, R; Clementi, F; Daga, A; Di Lascio, S; Fasoli, F; Gordon, TJ; Gotti, C; McIntosh, M; Moretti, M; Pucci, S; Viani, P; Zoli, M, 2021) |
| "We investigated the potential of [18F]fluorodeoxyglucose ([18F]FDG) and [18F]Fluoromethylcholine ([18F]FCho) PET, compared to contrast-enhanced MRI, for the early detection of treatment response in F98 glioblastoma (GB) rats." | 4.02 | Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI. ( Bolcaen, J; Boterberg, T; De Vos, F; Deblaere, K; Descamps, B; Goethals, I; Hallaert, G; Van den Broecke, C; Vanhove, C, 2021) |
| "In this study, we investigated fluorine-18 fluoromethylcholine (F-FCho) PET and contrast-enhanced MRI for predicting therapy response in glioblastoma (GB) patients according to the Response Assessment in Neuro-Oncology criteria." | 3.85 | 18F-FCho PET and MRI for the prediction of response in glioblastoma patients according to the RANO criteria. ( Acou, M; Bolcaen, J; Boterberg, T; De Vos, F; Deblaere, K; Goethals, I; Van den Broecke, C; Van Holen, R; Vanhove, C, 2017) |
| "Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volumes correlated with progression-free survival (PFS) and overall survival (OS) in patients with glioblastoma (GBM)." | 3.85 | Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. ( Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL, 2017) |
| "Positron emission tomography (PET) and PET/computed tomography (PET-CT) studies with (11)C- or (18)F-labeled choline derivatives are used for PET imaging in glioblastoma patients." | 3.80 | Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs. ( Hara, N; Inazu, M; Saiki, I; Taguchi, C; Uchino, H; Yamanaka, T; Yara, M, 2014) |
| "Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy." | 3.80 | 3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. ( Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC, 2014) |
| "Peritumoral N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, Cho/NAA and rCBV significantly differentiated glioblastomas from intracranial metastases." | 3.78 | Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. ( Fezoulidis, I; Fountas, K; Kapsalaki, E; Kousi, E; Svolos, P; Theodorou, K; Tsougos, I, 2012) |
| "A new method based on hydrophilic interaction chromatography-electrospray ionisation-tandem mass spectrometry (HILIC-ESI-MS/MS) coupled to the use of a stable isotope labelled substrate was developed to study the metabolism of choline (Cho) compounds in two human glioblastoma multiform (GBM) cell lines with different responses to ionising radiation." | 3.76 | Analysis of hydrophilic and lipophilic choline compounds in radioresistant and radiosensitive glioblastoma cell lines by HILIC-ESI-MS/MS. ( Balayssac, S; Claparols, C; Desoubzdanne, D; Gilard, V; Malet-Martino, M; Martino, R; Martins-Froment, N; Tercé, F; Zedde, C, 2010) |
| "In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)." | 3.73 | In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005) |
| "To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)." | 3.72 | Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004) |
| "Seven patients responded to tamoxifen therapy (three with glioblastomas multiforme; four with anaplastic astrocytomas), and nine did not (six with glioblastomas multiforme; three with anaplastic astrocytomas)." | 3.70 | Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy. ( Arnold, DL; Caramanos, Z; Langleben, A; LeBlanc, R; Preul, MC; Shenouda, G; Villemure, JG, 2000) |
| " The spectra from meningiomas, neuroblastomas, and glioblastomas displayed, in addition to similarities-including the presence of signals from leucine, isoleucine, valine, threonine, lactate, acetate, glutamate, choline-containing compounds and glycine-certain distinguishing metabolic features." | 3.69 | Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours. ( Bhakoo, KK; Florian, CL; Noble, M; Preece, NE; Williams, SR, 1995) |
| "Thirty-nine patients after the standard treatment of a glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence - median time to progression was 6." | 1.43 | Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging. ( Bulik, M; Jancalek, R; Kazda, T; Lakomy, R; Pospisil, P; Slampa, P; Smrcka, M, 2016) |
| "Cold choline was used for binding competition experiments." | 1.42 | Evidence of 18F-FCH Uptake in Human T98G Glioblastoma Cells. ( Aprile, C; Buroni, FE; Lodola, L; Nano, R; Pasi, F; Persico, MG, 2015) |
| "Glycine was detected in 24% of all studies, though with a wide range of signal amplitude and extent of the spatial distributions." | 1.40 | Mapping of glycine distributions in gliomas. ( Behari, S; Gupta, RK; Hussain, N; Maudsley, AA; Parra, NA; Roy, B; Sheriff, S; Stoyanova, R, 2014) |
| "Primary brain tumors (PBT), in particular gliomas, are among the most difficult neoplasms to treat, necessitating good quality imaging to guide clinicians at many junctures." | 1.37 | Promising role of [18F] fluorocholine PET/CT vs [18F] fluorodeoxyglucose PET/CT in primary brain tumors-early experience. ( Lam, WW; Ng, DC; Ong, SC; See, SJ; Wong, WY; Yu, SW, 2011) |
| "We examined 120 patients with brain tumors using a 1." | 1.31 | In vivo proton magnetic resonance spectroscopy of brain tumors. ( Fountas, KN; Gotsis, SD; Johnston, KW; Kapsalaki, EZ; Kapsalakis, JZ; Papadakis, N; Robinson, JS; Smisson , HF, 2000) |
| "Aspirated pus from one patient with brain abscess was examined using ex vivo proton MR spectroscopy." | 1.31 | Discrimination of brain abscess and cystic tumor by in vivo proton magnetic resonance spectroscopy. ( Kadota, O; Kikuchi, K; Kohno, K; Kumon, Y; Miki, H; Ohue, S; Sakaki, S, 2001) |
| "In pretreated glioblastoma metabolic data of MRSI seem to be potentially helpful to differentiate tumorous and non tumorous enhancement phenomena after local immunotherapy, which might be useful for further treatment decisions." | 1.31 | Comparative follow-up of enhancement phenomena with MRI and Proton MR Spectroscopic Imaging after intralesional immunotherapy in glioblastoma--Report of two exceptional cases. ( Engelbrecht, V; Floeth, FW; Weber, F; Wittsack, HJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.09) | 18.7374 |
| 1990's | 11 (11.96) | 18.2507 |
| 2000's | 32 (34.78) | 29.6817 |
| 2010's | 36 (39.13) | 24.3611 |
| 2020's | 12 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, A | 1 |
| Yuan, P | 1 |
| Huang, T | 1 |
| Li, L | 2 |
| Lyu, J | 1 |
| Yang, C | 1 |
| Wu, Y | 1 |
| Wang, L | 1 |
| Li, S | 1 |
| Zhou, J | 1 |
| Tan, Y | 2 |
| Song, J | 1 |
| Xing, H | 1 |
| Yi, K | 1 |
| Zhan, Q | 1 |
| Zhao, J | 1 |
| Wang, Q | 1 |
| Yuan, X | 1 |
| Kang, C | 1 |
| Bhaduri, S | 1 |
| Kelly, CL | 1 |
| Lesbats, C | 1 |
| Sharkey, J | 1 |
| Ressel, L | 1 |
| Mukherjee, S | 1 |
| Platt, MD | 1 |
| Delikatny, EJ | 1 |
| Poptani, H | 2 |
| Sidibe, I | 1 |
| Tensaouti, F | 2 |
| Gilhodes, J | 2 |
| Cabarrou, B | 1 |
| Filleron, T | 2 |
| Desmoulin, F | 2 |
| Ken, S | 3 |
| Noël, G | 2 |
| Truc, G | 2 |
| Sunyach, MP | 2 |
| Charissoux, M | 2 |
| Magné, N | 2 |
| Lotterie, JA | 2 |
| Roques, M | 2 |
| Péran, P | 2 |
| Cohen-Jonathan Moyal, E | 3 |
| Laprie, A | 4 |
| Ma, Q | 1 |
| Jiang, H | 1 |
| Ma, L | 1 |
| Zhao, G | 1 |
| Xu, Q | 1 |
| Guo, D | 1 |
| He, N | 1 |
| Liu, H | 2 |
| Meng, Z | 1 |
| Liu, J | 1 |
| Zhu, L | 1 |
| Lin, Q | 1 |
| Wu, X | 1 |
| Li, M | 1 |
| Luo, S | 1 |
| Fang, J | 1 |
| Lu, Z | 1 |
| Lubrano, V | 2 |
| Fuentes-Baile, M | 1 |
| Bello-Gil, D | 1 |
| Pérez-Valenciano, E | 1 |
| Sanz, JM | 1 |
| García-Morales, P | 1 |
| Maestro, B | 1 |
| Ventero, MP | 1 |
| Alenda, C | 1 |
| Barberá, VM | 1 |
| Saceda, M | 1 |
| Flores-Alvarez, E | 1 |
| Anselmo Rios Piedra, E | 1 |
| Cruz-Priego, GA | 1 |
| Durand-Muñoz, C | 1 |
| Moreno-Jimenez, S | 1 |
| Roldan-Valadez, E | 1 |
| Zhao, JP | 1 |
| Cui, CX | 1 |
| Wang, JC | 1 |
| Su, HW | 1 |
| Duan, CF | 1 |
| Liu, XJ | 1 |
| Pucci, S | 1 |
| Fasoli, F | 1 |
| Moretti, M | 1 |
| Benfante, R | 1 |
| Di Lascio, S | 1 |
| Viani, P | 1 |
| Daga, A | 1 |
| Gordon, TJ | 1 |
| McIntosh, M | 1 |
| Zoli, M | 1 |
| Clementi, F | 1 |
| Gotti, C | 1 |
| Bolcaen, J | 4 |
| Descamps, B | 3 |
| Deblaere, K | 4 |
| De Vos, F | 3 |
| Boterberg, T | 4 |
| Hallaert, G | 1 |
| Van den Broecke, C | 4 |
| Vanhove, C | 4 |
| Goethals, I | 4 |
| Kumon, M | 1 |
| Nakae, S | 1 |
| Murayama, K | 1 |
| Kato, T | 1 |
| Ohba, S | 1 |
| Inamasu, J | 1 |
| Yamada, S | 1 |
| Abe, M | 1 |
| Sasaki, H | 1 |
| Ohno, Y | 1 |
| Hasegawa, M | 1 |
| Kurahashi, H | 1 |
| Hirose, Y | 1 |
| Chen, F | 1 |
| Li, Z | 1 |
| Weng, C | 1 |
| Li, P | 1 |
| Tu, L | 1 |
| Chen, L | 1 |
| Xie, W | 1 |
| Agliano, A | 2 |
| Balarajah, G | 2 |
| Ciobota, DM | 1 |
| Sidhu, J | 1 |
| Clarke, PA | 2 |
| Jones, C | 2 |
| Workman, P | 2 |
| Leach, MO | 2 |
| Al-Saffar, NMS | 1 |
| Pasi, F | 2 |
| Persico, MG | 2 |
| Buroni, FE | 2 |
| Aprile, C | 2 |
| Hodolic, M | 1 |
| Corbella, F | 1 |
| Nano, R | 2 |
| Facoetti, A | 1 |
| Lodola, L | 2 |
| Alongi, P | 1 |
| Vetrano, IG | 1 |
| Fiasconaro, E | 1 |
| Alaimo, V | 1 |
| Laudicella, R | 1 |
| Bellavia, M | 1 |
| Rubino, F | 1 |
| Bagnato, S | 1 |
| Galardi, G | 1 |
| Gurbani, SS | 2 |
| Sheriff, S | 2 |
| Maudsley, AA | 3 |
| Shim, H | 2 |
| Cooper, LAD | 1 |
| Ratai, EM | 1 |
| Zhang, Z | 1 |
| Snyder, BS | 1 |
| Boxerman, JL | 1 |
| Safriel, Y | 1 |
| McKinstry, RC | 1 |
| Bokstein, F | 1 |
| Gilbert, MR | 1 |
| Sorensen, AG | 1 |
| Barboriak, DP | 1 |
| Gupta, RK | 2 |
| Stoyanova, R | 2 |
| Parra, NA | 2 |
| Roy, B | 2 |
| Hussain, N | 1 |
| Behari, S | 1 |
| Taguchi, C | 1 |
| Inazu, M | 1 |
| Saiki, I | 1 |
| Yara, M | 1 |
| Hara, N | 1 |
| Yamanaka, T | 1 |
| Uchino, H | 1 |
| Muruganandham, M | 1 |
| Clerkin, PP | 1 |
| Smith, BJ | 1 |
| Anderson, CM | 1 |
| Morris, A | 1 |
| Capizzano, AA | 1 |
| Magnotta, V | 1 |
| McGuire, SM | 1 |
| Smith, MC | 1 |
| Bayouth, JE | 1 |
| Buatti, JM | 1 |
| Ishkanian, F | 1 |
| Huang, K | 1 |
| Walker, GR | 1 |
| Padgett, K | 1 |
| Panoff, J | 1 |
| Markoe, A | 1 |
| Al-Saffar, NM | 1 |
| Marshall, LV | 1 |
| Jackson, LE | 1 |
| Eykyn, TR | 1 |
| Pearson, AD | 1 |
| Deviers, A | 1 |
| Rowland, B | 1 |
| Laruelo, A | 1 |
| Catalaa, I | 3 |
| Celsis, P | 1 |
| Berry, I | 2 |
| Mogicato, G | 1 |
| De Vos Pharm, F | 1 |
| Kalala, JP | 2 |
| Decrock, E | 1 |
| Leybaert, L | 1 |
| Stadlbauer, A | 1 |
| Pichler, P | 1 |
| Karl, M | 1 |
| Brandner, S | 1 |
| Lerch, C | 1 |
| Renner, B | 1 |
| Heinz, G | 1 |
| Tang, C | 1 |
| Guo, J | 1 |
| Chen, H | 1 |
| Yao, CJ | 1 |
| Zhuang, DX | 1 |
| Wang, Y | 1 |
| Tang, WJ | 1 |
| Ren, G | 1 |
| Yao, Y | 1 |
| Wu, JS | 1 |
| Mao, Y | 1 |
| Zhou, LF | 1 |
| Fu, Y | 1 |
| Ong, LC | 1 |
| Ranganath, SH | 1 |
| Zheng, L | 1 |
| Kee, I | 1 |
| Zhan, W | 1 |
| Yu, S | 1 |
| Chow, PK | 1 |
| Wang, CH | 1 |
| Cordova, JS | 1 |
| Shu, HK | 1 |
| Liang, Z | 1 |
| Cooper, LA | 1 |
| Holder, CA | 1 |
| Olson, JJ | 1 |
| Kairdolf, B | 1 |
| Schreibmann, E | 1 |
| Neill, SG | 1 |
| Hadjipanayis, CG | 1 |
| Mohan, S | 1 |
| Chawla, S | 1 |
| Wang, S | 1 |
| Verma, G | 1 |
| Skolnik, A | 1 |
| Brem, S | 1 |
| Peters, KB | 1 |
| Kazda, T | 1 |
| Bulik, M | 1 |
| Pospisil, P | 1 |
| Lakomy, R | 1 |
| Smrcka, M | 1 |
| Slampa, P | 1 |
| Jancalek, R | 1 |
| Nelson, SJ | 9 |
| Li, Y | 2 |
| Lupo, JM | 1 |
| Olson, M | 2 |
| Crane, JC | 1 |
| Molinaro, A | 2 |
| Roy, R | 2 |
| Clarke, J | 1 |
| Butowski, N | 2 |
| Prados, M | 1 |
| Cha, S | 5 |
| Chang, SM | 4 |
| Lybaert, K | 1 |
| Moerman, L | 1 |
| Kadambi, AK | 1 |
| Park, I | 1 |
| Crane, J | 1 |
| Chang, S | 5 |
| Koch, K | 1 |
| Hartmann, R | 1 |
| Schröter, F | 1 |
| Suwala, AK | 1 |
| Maciaczyk, D | 1 |
| Krüger, AC | 1 |
| Willbold, D | 1 |
| Kahlert, UD | 1 |
| Maciaczyk, J | 1 |
| Acou, M | 1 |
| Van Holen, R | 1 |
| Boonzaier, NR | 1 |
| Larkin, TJ | 1 |
| Matys, T | 1 |
| van der Hoorn, A | 1 |
| Yan, JL | 1 |
| Price, SJ | 1 |
| Thorsen, F | 1 |
| Jirak, D | 1 |
| Wang, J | 1 |
| Sykova, E | 1 |
| Bjerkvig, R | 1 |
| Enger, PØ | 1 |
| van der Kogel, A | 1 |
| Hajek, M | 1 |
| Saraswathy, S | 2 |
| Crawford, FW | 2 |
| Lamborn, KR | 2 |
| Pirzkall, A | 5 |
| Khayal, IS | 1 |
| McGue, C | 1 |
| Berger, MS | 1 |
| Vanpouille, C | 1 |
| Le Jeune, N | 1 |
| Kryza, D | 1 |
| Clotagatide, A | 1 |
| Janier, M | 1 |
| Dubois, F | 1 |
| Perek, N | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Srinivasan, R | 1 |
| Phillips, JJ | 1 |
| Vandenberg, SR | 1 |
| Polley, MY | 1 |
| Bourne, G | 1 |
| Au, A | 1 |
| Desoubzdanne, D | 1 |
| Claparols, C | 1 |
| Martins-Froment, N | 1 |
| Zedde, C | 1 |
| Balayssac, S | 1 |
| Gilard, V | 1 |
| Tercé, F | 1 |
| Martino, R | 1 |
| Malet-Martino, M | 1 |
| Lam, WW | 1 |
| Ng, DC | 1 |
| Wong, WY | 1 |
| Ong, SC | 1 |
| Yu, SW | 1 |
| See, SJ | 1 |
| Davila, M | 1 |
| Candiota, AP | 1 |
| Pumarola, M | 1 |
| Arus, C | 1 |
| Einstein, DB | 1 |
| Wessels, B | 1 |
| Bangert, B | 1 |
| Fu, P | 1 |
| Nelson, AD | 1 |
| Cohen, M | 1 |
| Sagar, S | 1 |
| Lewin, J | 1 |
| Sloan, A | 1 |
| Zheng, Y | 1 |
| Williams, J | 1 |
| Colussi, V | 1 |
| Vinkler, R | 1 |
| Maciunas, R | 1 |
| Zhu, M | 1 |
| Fischl, AS | 1 |
| Trowbridge, MA | 1 |
| Shannon, HE | 1 |
| Jeon, JY | 1 |
| Kovanlikaya, I | 1 |
| Boockvar, JA | 1 |
| Mao, X | 1 |
| Shin, B | 1 |
| K Burkhardt, J | 1 |
| Kesavabhotla, K | 1 |
| Christos, P | 1 |
| Riina, H | 1 |
| Shungu, DC | 1 |
| Tsiouris, AJ | 1 |
| Lima, EC | 1 |
| Otaduy, MC | 2 |
| Tsunemi, M | 1 |
| Pincerato, R | 1 |
| Cardoso, EF | 1 |
| Rosemberg, S | 1 |
| Aguiar, PH | 1 |
| Cerri, GG | 1 |
| Leite, CC | 1 |
| Tsougos, I | 1 |
| Svolos, P | 1 |
| Kousi, E | 1 |
| Fountas, K | 1 |
| Theodorou, K | 1 |
| Fezoulidis, I | 1 |
| Kapsalaki, E | 1 |
| Gmeiner, M | 1 |
| Sonnberger, M | 1 |
| Wurm, G | 1 |
| Weis, S | 1 |
| Rabinov, JD | 1 |
| Lee, PL | 1 |
| Barker, FG | 1 |
| Louis, DN | 1 |
| Harsh, GR | 1 |
| Cosgrove, GR | 1 |
| Chiocca, EA | 1 |
| Thornton, AF | 1 |
| Loeffler, JS | 1 |
| Henson, JW | 1 |
| Gonzalez, RG | 2 |
| Howe, FA | 1 |
| Barton, SJ | 1 |
| Cudlip, SA | 1 |
| Stubbs, M | 1 |
| Saunders, DE | 1 |
| Murphy, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Phase II Trial of Conventional Radiotherapy With Stereotactic Radiosurgery to High Risk Tumor Regions as Determined by Functional Imaging in Patients With Glioblastoma Multiforme[NCT00253448] | Phase 2 | 35 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| Ependymomics: Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents[NCT05151718] | 370 participants (Anticipated) | Observational | 2021-09-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Followed every 3 months for 2 years, every 6 months for 3 years, and annually thereafter for at least 5 years (NCT00253448)
Timeframe: Minimum of 5 years.
| Intervention | months (Median) | ||||||
|---|---|---|---|---|---|---|---|
| Entire Cohort | RTOG Glioma Recursive Partitioning Class 3 n=4 | RTOG Glioma Recursive Partitioning Class 4 n=13 | RTOG Glioma Recursive Partitioning Class 5 n=16 | RTOG Glioma Recursive Partitioning Class 6 n=2 | Patients receiving concurrent chemotherapy | Patients who were not candidates for chemotherapy | |
| Stereotactic Radiosurgery Plus Conventional Radiotherapy | 15.8 | 22 | 18.7 | 12.5 | 3.9 | 20.8 | 11 |
4 reviews available for choline and Glioblastoma
| Article | Year |
|---|---|
Progressive multifocal exophytic pontine glioblastoma: a case report with literature review.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child, Preschool; Choline; Diagnosis, Differential; Fatal Outco | 2017 |
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
Glioblastoma with the appearance of arteriovenous malformation: pitfalls in diagnosis.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Choline; Diagnosis, | 2013 |
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates; | 1992 |
8 trials available for choline and Glioblastoma
| Article | Year |
|---|---|
Pseudoprogression in GBM versus true progression in patients with glioblastoma: A multiapproach analysis.
Topics: Brain Neoplasms; Choline; Disease Progression; Glioblastoma; Humans; Magnetic Resonance Imaging; Neo | 2023 |
Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Be | 2013 |
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea | 2014 |
Phase II trial of radiosurgery to magnetic resonance spectroscopy-defined high-risk tumor volumes in patients with glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Combined Modality Therapy; | 2012 |
Metabolic response of glioblastoma to superselective intra-arterial cerebral infusion of bevacizumab: a proton MR spectroscopic imaging study.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Aspartic Acid; Bevacizumab; Brain; | 2012 |
[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Chol | 2007 |
Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Magnetic Resonance Ima | 2008 |
Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Pr | 1996 |
80 other studies available for choline and Glioblastoma
| Article | Year |
|---|---|
Distinguishing Tumor Recurrence From Radiation Necrosis in Treated Glioblastoma Using Multiparametric MRI.
Topics: Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; | 2022 |
Glioma-derived exosomes hijack the blood-brain barrier to facilitate nanocapsule delivery via LCN2.
Topics: Blood-Brain Barrier; Choline; Endothelial Cells; Exosomes; Glioblastoma; Glioma; Humans; Lipocalin-2 | 2022 |
Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models.
Topics: Animals; Brain Neoplasms; Choline; Choline Kinase; Glioblastoma; Mice; Rats; Receptors, Antigen, T-C | 2023 |
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation.
Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Choline; Glioblastoma; Humans; Phospholipid | 2023 |
Is pre-radiotherapy metabolic heterogeneity of glioblastoma predictive of progression-free survival?
Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magnetic Resonance Imaging; | 2023 |
CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells.
Topics: 3T3-L1 Cells; Adenocarcinoma; Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; | 2020 |
Correlations between DTI-derived metrics and MRS metabolites in tumour regions of glioblastoma: a pilot study.
Topics: Anisotropy; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Contrast Media; Creatine; Di | 2020 |
Multimodal MR Features of 8 Cases of Epithelioid Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Diffusi | 2020 |
Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chol | 2021 |
Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI.
Topics: Animals; Cell Line, Tumor; Choline; Contrast Media; Female; Fluorodeoxyglucose F18; Glioblastoma; Ma | 2021 |
Myoinositol to Total Choline Ratio in Glioblastomas as a Potential Prognostic Factor in Preoperative Magnetic Resonance Spectroscopy.
Topics: Brain Neoplasms; Choline; Glioblastoma; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonan | 2021 |
Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy.
Topics: Adult; Animals; Biomarkers; Cell Line, Tumor; Cell Survival; Child; Choline; Energy Metabolism; Fema | 2017 |
Uptake of
Topics: Carbon; Cell Line, Tumor; Choline; Diagnosis, Differential; Glioblastoma; Humans; Ions; Neoplasm Met | 2017 |
Choline-PET/CT in the Differential Diagnosis Between Cystic Glioblastoma and Intraparenchymal Hemorrhage.
Topics: Brain Neoplasms; Cerebral Hemorrhage; Choline; Diagnosis, Differential; Glioblastoma; Humans; Magnet | 2019 |
Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting.
Topics: Algorithms; Artifacts; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Computer Graphics; Cr | 2019 |
Mapping of glycine distributions in gliomas.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Mapping; Brain Neoplasms; Choline; Diffusion Magn | 2014 |
Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs.
Topics: Antigens, CD; Antineoplastic Agents; Astrocytes; Cell Line, Tumor; Cell Survival; Central Nervous Sy | 2014 |
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; C | 2014 |
Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Brain Mapping; Brain Neoplasms; Choline; Creatine; F | 2014 |
Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma.
Topics: Cell Line, Tumor; Choline; Flow Cytometry; Glioblastoma; Humans; Immunoblotting; Lactic Acid; Magnet | 2014 |
(18)F-fluoromethylcholine (FCho), (18)F-fluoroethyltyrosine (FET), and (18)F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Diagnosis, Differential; Female; Fluorodeoxyglu | 2015 |
Quantification of serial changes in cerebral blood volume and metabolism in patients with recurrent glioblastoma undergoing antiangiogenic therapy.
Topics: Angiogenesis Inhibitors; Aspartic Acid; Bevacizumab; Blood Volume; Brain; Brain Mapping; Brain Neopl | 2015 |
Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Codon, Nonsense; DNA | 2015 |
Evidence of 18F-FCH Uptake in Human T98G Glioblastoma Cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Choline; Fluorodeoxyglucose F18; Glioblastoma; Humans; Radionucli | 2015 |
A Dual Tracer 18F-FCH/18F-FDG PET Imaging of an Orthotopic Brain Tumor Xenograft Model.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Disease Models, Animal; Fluorodeoxyglucose F18; | 2016 |
Whole-brain spectroscopic MRI biomarkers identify infiltrating margins in glioblastoma patients.
Topics: Aminolevulinic Acid; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Count; Choline; Disease | 2016 |
Assessment of early response to tumor-treating fields in newly diagnosed glioblastoma using physiologic and metabolic MRI: initial experience.
Topics: Anisotropy; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Blood Volume; Choline; Crea | 2016 |
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Cohort Studies; Diffusion Magnetic Resonance I | 2016 |
Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab.
Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Chol | 2016 |
Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats.
Topics: Animals; Brain; Cell Line, Tumor; Choline; Diagnosis, Differential; Disease Models, Animal; Female; | 2016 |
Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cho | 2017 |
Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Survival; Choline; Choline Kinase; Dacarbazine; Energy Metab | 2016 |
18F-FCho PET and MRI for the prediction of response in glioblastoma patients according to the RANO criteria.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Image Processing, Computer-Assi | 2017 |
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor I | 2017 |
Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Glioblastoma; Glutamic Acid; Magnetic Resonance | 2008 |
Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy.
Topics: Adult; Aged; Asparagine; Brain Mapping; Brain Neoplasms; Choline; Contrast Media; Creatine; Drug The | 2009 |
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM.
Topics: Adult; Aged; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti | 2009 |
Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model.
Topics: Animals; Biological Transport; Cell Line, Tumor; Choline; Choline Kinase; Drug Resistance, Multiple; | 2009 |
Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM.
Topics: Biomarkers, Tumor; Brain Neoplasms; Choline; Glioblastoma; Humans; Image Interpretation, Computer-As | 2010 |
Analysis of hydrophilic and lipophilic choline compounds in radioresistant and radiosensitive glioblastoma cell lines by HILIC-ESI-MS/MS.
Topics: Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Choline; Chromatography, Liquid; Gliobla | 2010 |
Promising role of [18F] fluorocholine PET/CT vs [18F] fluorodeoxyglucose PET/CT in primary brain tumors-early experience.
Topics: Brain Neoplasms; Choline; Fatal Outcome; Female; Fluorine Radioisotopes; Glioblastoma; Glioma; Human | 2011 |
Minimization of spectral pattern changes during HRMAS experiments at 37 degrees celsius by prior focused microwave irradiation.
Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Choline; Glioblastoma; Humans; Lipids; Magnetic R | 2012 |
Reproducibility of total choline/water ratios in mouse U87MG xenograft tumors by 1H-MRS.
Topics: Animals; Biomarkers, Tumor; Body Water; Cell Line, Tumor; Choline; Glioblastoma; Humans; Magnetic Re | 2012 |
The effect of paramagnetic contrast in choline peak in patients with glioblastoma multiforme might not be significant.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Choline; Contrast Media; Electron Spin Reson | 2013 |
Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, D | 2012 |
In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience.
Topics: Adult; Astrocytoma; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Female; Gliobl | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Blood Volume; Brain Neoplasms; Choline; Glioblastoma; Humans | 2004 |
Combined use of F-18 fluorocholine positron emission tomography and magnetic resonance spectroscopy for brain tumor evaluation.
Topics: Adult; Brain; Brain Neoplasms; Choline; Demyelinating Diseases; Female; Fluorine Radioisotopes; Glio | 2004 |
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor | 2004 |
123I-IMT SPECT and 1H MR-spectroscopy at 3.0 T in the differential diagnosis of recurrent or residual gliomas: a comparative study.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Female; Glioblastoma; Huma | 2004 |
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin | 2005 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla | 2005 |
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors].
Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined | 2006 |
Correlation between amplification of the gene for the epidermal growth factor receptor (EGFR), data from preoperative proton-MR-spectroscopy (1HMRS) and histomorphometric data of glioblastomas.
Topics: Adult; Aged; Brain Neoplasms; Cell Nucleus; Choline; Creatine; ErbB Receptors; Gene Amplification; G | 2007 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Analysis of brain tumors using 1H magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magneti | 1995 |
Imaging brain tumors -- beyond three dimensions.
Topics: Aged; Alanine; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Lactates; Lactic Acid; Magnet | 1996 |
Single-voxel proton brain spectroscopy exam (PROBE/SV) in patients with primary brain tumors.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Crea | 1996 |
Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours.
Topics: Alanine; Amino Acids; Brain Neoplasms; Choline; Chromatography, High Pressure Liquid; Creatine; Glio | 1995 |
Immortalization and transformation are associated with specific alterations in choline metabolism.
Topics: Animals; Antigens, Viral, Tumor; Cell Division; Cell Line, Transformed; Choline; Glioblastoma; Human | 1996 |
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.
Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Pro | 1997 |
Proton MR spectroscopy of delayed cerebral radiation in monkeys and humans after brachytherapy.
Topics: Adult; Animals; Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Cranial Irradiation; | 1997 |
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms; | 1999 |
Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Astro | 2000 |
A preliminary study of the prognostic value of proton magnetic resonance spectroscopic imaging in gamma knife radiosurgery of recurrent malignant gliomas.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Choline; Creatine; Female; Glioblastoma; Humans; Lactic Aci | 2000 |
Effect of voxel position on single-voxel MR spectroscopy findings.
Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio | 2000 |
Correlation of myo-inositol levels and grading of cerebral astrocytomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil | 2000 |
In vivo proton magnetic resonance spectroscopy of brain tumors.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Brain; Brain Abscess; Brain Neoplasms; Choline | 2000 |
Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy.
Topics: Adult; Biopsy; Brain Neoplasms; Choline; Glioblastoma; Gliosis; Humans; Lactates; Lipids; Magnetic R | 2000 |
Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined | 2001 |
Discrimination of brain abscess and cystic tumor by in vivo proton magnetic resonance spectroscopy.
Topics: Acetates; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Bacteria; Biomarkers; Brain Abscess; Child; | 2001 |
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop | 2001 |
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil | 2001 |
In vivo single-voxel proton MR spectroscopy in brain lesions with ring-like enhancement.
Topics: Adult; Aged; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; Cerebral Infarction; Choline; Cr | 2001 |
[1H-MR Spectroscopy of brain tumors in the course of radiation therapy: Use of fast spectroscopic imaging and single-voxel spectroscopy for diagnosing recurrence].
Topics: Adult; Aged; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Cranial Irradiation; Energy | 2002 |
Comparative follow-up of enhancement phenomena with MRI and Proton MR Spectroscopic Imaging after intralesional immunotherapy in glioblastoma--Report of two exceptional cases.
Topics: Adult; Brain Neoplasms; Choline; Fatal Outcome; Female; Glioblastoma; Humans; Image Processing, Comp | 2002 |
Choline uptake in glial cell cultures.
Topics: Animals; Brain Neoplasms; Cells, Cultured; Choline; Clone Cells; Cricetinae; Glioblastoma; Neuroglia | 1974 |