choline has been researched along with Gaucher Disease in 5 studies
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fabry and Gaucher diseases are rare progressive inherited disorders of glycosphingolipid metabolism that affect multiple organ systems." | 1.37 | Magnetic resonance spectroscopy in patients with Fabry and Gaucher disease. ( Bodamer, O; Bogner, W; Gruber, S; Krssak, M; Stadlbauer, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Razek, AA | 1 |
| Abdalla, A | 1 |
| Gaber, NA | 1 |
| Fathy, A | 1 |
| Megahed, A | 1 |
| Barakat, T | 1 |
| Latif Alsayed, MA | 1 |
| Gruber, S | 2 |
| Bogner, W | 1 |
| Stadlbauer, A | 2 |
| Krssak, M | 1 |
| Bodamer, O | 1 |
| Bodennec, J | 1 |
| Pelled, D | 1 |
| Riebeling, C | 1 |
| Trajkovic, S | 1 |
| Futerman, AH | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Rolfs, A | 1 |
| Woeber, C | 1 |
| Kurnik, P | 1 |
| Voigtlaender, T | 1 |
| Moser, E | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Tedeschi, G | 1 |
| Schiffmann, R | 1 |
| Barton, NW | 1 |
| Shih, HH | 1 |
| Gospe, SM | 1 |
| Brady, RO | 1 |
| Alger, JR | 1 |
| Di Chiro, G | 1 |
5 other studies available for choline and Gaucher Disease
| Article | Year |
|---|---|
Proton MR Spectroscopy of the brain in children with neuronopathic Gaucher's disease.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Child, Preschool; Choline; Creatine; Diagnosis, D | 2013 |
Magnetic resonance spectroscopy in patients with Fabry and Gaucher disease.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Fabry Disease; Female; Gaucher Diseas | 2011 |
Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide.
Topics: Animals; Axons; Brain; Carbon Radioisotopes; Cell Division; Choline; Choline-Phosphate Cytidylyltran | 2002 |
Neurological and brain MRS findings in patients with Gaucher disease type 1.
Topics: Adolescent; Adult; Brain; Brain Mapping; Choline; Electrophysiology; Female; Gaucher Disease; Humans | 2007 |
Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination.
Topics: Aspartic Acid; Ataxia; Brain; Brain Diseases; Child, Preschool; Choline; Creatine; Female; Gaucher D | 1995 |