choline has been researched along with Friedreich Ataxia in 4 studies
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of orally administered choline chloride in the treatment of cerebellar and spinocerebellar ataxia was investigated by a short-term double-blind crossover trial in 20 patients with ataxia." | 7.66 | Choline chloride in the treatment of cerebellar and spinocerebellar ataxia. ( Livingstone, IR; Mastaglia, FL; Pennington, RJ; Skilbeck, C, 1981) |
| "The use of orally administered choline chloride in the treatment of cerebellar and spinocerebellar ataxia was investigated by a short-term double-blind crossover trial in 20 patients with ataxia." | 3.66 | Choline chloride in the treatment of cerebellar and spinocerebellar ataxia. ( Livingstone, IR; Mastaglia, FL; Pennington, RJ; Skilbeck, C, 1981) |
| "Four patients with Friedreich's ataxia took part in an open trial, in which they consumed 50-100g/day lecithin granules (containing approximately 22% phosphatidycholine) for 16 weeks, but no improvement resulted." | 1.26 | Effect of lecithin on disability and plasma free-choline levels in Friedreich's ataxia. ( Benton, S; Bradbury, S; Chamberlain, S; Kennard, C; Kilkenny, B; Robinson, N; Smith, C; Swash, M; Walker, J, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gramegna, LL | 1 |
| Tonon, C | 1 |
| Manners, DN | 1 |
| Pini, A | 1 |
| Rinaldi, R | 1 |
| Zanigni, S | 1 |
| Bianchini, C | 1 |
| Evangelisti, S | 1 |
| Fortuna, F | 1 |
| Carelli, V | 1 |
| Testa, C | 1 |
| Lodi, R | 1 |
| Livingstone, IR | 1 |
| Mastaglia, FL | 1 |
| Pennington, RJ | 1 |
| Skilbeck, C | 1 |
| Chamberlain, S | 1 |
| Robinson, N | 1 |
| Walker, J | 1 |
| Smith, C | 1 |
| Benton, S | 1 |
| Kennard, C | 1 |
| Swash, M | 1 |
| Kilkenny, B | 1 |
| Bradbury, S | 1 |
| Barbeau, A | 1 |
1 review available for choline and Friedreich Ataxia
| Article | Year |
|---|---|
Emerging treatments: replacement therapy with choline or lecithin in neurological diseases.
Topics: Animals; Choline; Dyskinesia, Drug-Induced; Friedreich Ataxia; Humans; Huntington Disease; Nervous S | 1978 |
3 other studies available for choline and Friedreich Ataxia
| Article | Year |
|---|---|
Combined Cerebellar Proton MR Spectroscopy and DWI Study of Patients with Friedreich's Ataxia.
Topics: Adolescent; Adult; Aspartic Acid; Cerebellum; Child; Choline; Diffusion Magnetic Resonance Imaging; | 2017 |
Choline chloride in the treatment of cerebellar and spinocerebellar ataxia.
Topics: Adult; Cerebellar Ataxia; Choline; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fr | 1981 |
Effect of lecithin on disability and plasma free-choline levels in Friedreich's ataxia.
Topics: Adolescent; Adult; Choline; Female; Friedreich Ataxia; Humans; Male; Middle Aged; Phosphatidylcholin | 1980 |