Page last updated: 2024-10-16

choline and Folic Acid Deficiency

choline has been researched along with Folic Acid Deficiency in 51 studies

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research Excerpts

ExcerptRelevanceReference
"Adequate choline intake during pregnancy is essential for proper fetal development."8.91[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. ( Drews, K, 2015)
"Severe choline deficiency adversely affects cellular methylation and DNA integrity, with potentially serious implications for disease risk."5.14Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men. ( Abratte, CM; Caudill, MA; Shin, W; Vermeylen, F; Yan, J, 2010)
"Adequate choline intake during pregnancy is essential for proper fetal development."4.91[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. ( Drews, K, 2015)
"To dissociate the effects of dietary folate and choline deficiency on Shmt1-related NTD sensitivity, we determined NTD incidence in embryos from Shmt1-null dams fed diets deficient in either folate or choline."3.78Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. ( Abarinov, EV; Beaudin, AE; Caudill, M; Malysheva, O; Perry, CA; Stover, PJ, 2012)
"Reduced folate and choline status resulted in severe fetal growth restriction (FGR) and impaired fertility in litters harvested from Mthfd1(gt/+) dams, but embryonic Mthfd1(gt/+) genotype did not affect fetal growth."3.78Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. ( Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ, 2012)
"We examined whether genetic disruption of the Shmt1 gene in mice induces NTDs in response to maternal folate and choline deficiency and whether a corresponding disruption in de novo thymidylate biosynthesis underlies NTD pathogenesis."3.77Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. ( Abarinov, EV; Allen, RH; Beaudin, AE; Chu, S; Noden, DM; Perry, CA; Stabler, SP; Stover, PJ, 2011)
" Folic acid deficiency, as indicated by retarded growth and feed efficiency, could be produced in 18-day-old chicks."3.68Folate deficiency in chicks fed diets containing practical ingredients. ( Pesti, GM; Rowland, GN; Ryu, KS, 1991)
" Each of 50 rats per group received one injection 20 mg diethylnitrosamine [(DENA) CAS: 55-18-5; N-nitrosodiethylamine]/kg body weight at 4 weeks of age, and then each was maintained on a methyl group-adequate (MA) diet for 52 weeks (groups 2 and 5) or on an MD diet for 15 weeks followed by the MA diet for 37 weeks (group 4)."3.67Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection. ( Hoover, KL; Lynch, PH; Poirier, LA, 1984)
" Later work indicated that in rats and mice, diets deficient in labile methyl groups (choline, methionine, betaine, folate) produced fatty liver and that long-term administration of diets deficient in choline and methionine also caused hepatocellular carcinoma."2.44Methionine metabolism and liver disease. ( Lu, SC; Martínez-Chantar, ML; Mato, JM, 2008)
" Previous studies have shown that the long-term administration of a diet lacking essential one-carbon nutrients such as methionine, choline and folic acid (methyl donors) caused global DNA hypermethylation in the brain."1.42Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus. ( Ishii, D; Kawai, K; Mashimo, Y; Matsuda, S; Matsuzawa, D; Shimizu, E; Sutoh, C; Tomizawa, H, 2015)
"Choline is a required nutrient with roles in liver and brain function, lipid metabolism, and fetal development."1.35Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. ( Caudill, MA; Hinkis, S; Ivanov, A; Nash-Barboza, S, 2009)

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-199015 (29.41)18.7374
1990's9 (17.65)18.2507
2000's6 (11.76)29.6817
2010's20 (39.22)24.3611
2020's1 (1.96)2.80

Authors

AuthorsStudies
Tillmann, S1
Awwad, HM1
MacPherson, CW1
Happ, DF1
Treccani, G1
Geisel, J1
Tompkins, TA1
Ueland, PM1
Wegener, G1
Obeid, R2
Pogribny, IP2
Kutanzi, K2
Melnyk, S2
de Conti, A2
Tryndyak, V2
Montgomery, B1
Pogribna, M1
Muskhelishvili, L1
Latendresse, JR2
James, SJ3
Beland, FA2
Rusyn, I2
Morrow, GP1
MacMillan, L1
Lamarre, SG1
Young, SK1
MacFarlane, AJ1
Brosnan, ME1
Brosnan, JT1
Tomizawa, H1
Matsuzawa, D1
Ishii, D1
Matsuda, S1
Kawai, K1
Mashimo, Y1
Sutoh, C1
Shimizu, E1
Drews, K1
Ganz, AB1
Shields, K1
Fomin, VG1
Lopez, YS1
Mohan, S1
Lovesky, J1
Chuang, JC1
Ganti, A1
Carrier, B1
Yan, J3
Taeswuan, S1
Cohen, VV1
Swersky, CC1
Stover, JA1
Vitiello, GA1
Malysheva, OV2
Mudrak, E1
Caudill, MA7
Batra, V1
Devasagayam, TP1
Ivanov, A1
Nash-Barboza, S1
Hinkis, S1
Shin, W1
Abratte, CM1
Vermeylen, F1
Craciunescu, CN1
Johnson, AR1
Zeisel, SH2
Christensen, KE1
Wu, Q2
Wang, X2
Deng, L1
Rozen, R2
Crivello, NA1
Blusztajn, JK1
Joseph, JA1
Shukitt-Hale, B1
Smith, DE1
Wang, W2
Gregory, JF1
Malysheva, O2
Brenna, JT1
Stabler, SP4
Allen, RH4
Beaudin, AE3
Abarinov, EV3
Noden, DM1
Perry, CA3
Chu, S1
Stover, PJ4
Caudill, M2
Shane, B1
Schoendorfer, NC1
Moxon-Lester, L1
Sharp, N1
Vitetta, L1
Boyd, RN1
Davies, PS1
Lu, L1
Ni, J1
Zhou, T1
Xu, W1
Fenech, M1
Bressenot, A1
Pooya, S1
Bossenmeyer-Pourie, C1
Gauchotte, G1
Germain, A1
Chevaux, JB1
Coste, F1
Vignaud, JM1
Guéant, JL2
Peyrin-Biroulet, L1
Kobets, T1
Koturbash, I1
Han, T1
Fuscoe, JC1
Shymonyak, S1
Collins, L1
Ross, SA1
Mikael, LG1
Pancer, J1
Jiang, X1
Field, MS1
Shields, KS1
Ash, JA1
Strupp, BJ1
Brunaud, L1
Alberto, JM1
Ayav, A1
Gérard, P1
Namour, F1
Antunes, L1
Braun, M1
Bronowicki, JP1
Bresler, L1
STEKOL, JA2
WEISS, S2
SMITH, P1
WEISS, K1
DINNING, JS1
NEATROUR, R1
DAY, PL1
ANDERSON, EI1
HSU, PT1
WATJEN, A1
DALAL, FR1
FATTERPAKER, P1
REGE, DV1
SREENIVASAN, A1
MACDONALD, RA1
JONES, RS1
PECHET, GS1
Maloney, CA1
Hay, SM1
Rees, WD1
Solis, C1
Veenema, K1
Ivanov, AA1
Tran, S1
Li, R1
Moriarty, DJ1
Maletz, CV1
Mato, JM1
Martínez-Chantar, ML1
Lu, SC1
Hoover, KL1
Lynch, PH1
Poirier, LA4
Jacob, RA3
Pianalto, FS1
Henning, SM3
Zhang, JZ1
Swendseid, ME4
Park, CS1
Choi, CB1
Baik, MG1
Keller, WL1
Kim, YI1
Miller, JW1
da Costa, KA1
Nadeau, M1
Smith, D1
Selhub, J1
Mason, JB1
Wu, MM1
Glade, MJ1
Jenden, DJ1
Allman-Farinelli, MA1
Petri, WA1
Asoklis, K1
Asoklis, R1
Cross, DR1
Miller, BJ1
Pesti, GM1
Rowland, GN1
Ryu, KS1
Newberne, PM1
Rogers, AE1
Yin, L1
Blair, R1
Newsome, F1
Whitehead, VM1
Keshavarz, K1
Fuller, HL1
Miller, DL1
Balloun, SL1

Reviews

6 reviews available for choline and Folic Acid Deficiency

ArticleYear
[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy].
    Ginekologia polska, 2015, Volume: 86, Issue:12

    Topics: Choline; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Humans; Maternal Nutritiona

2015
Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.
    Clinical chemistry and laboratory medicine, 2003, Volume: 41, Issue:8

    Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diet; DNA Methylation; Folic Acid Deficiency; Gas

2003
Methionine metabolism and liver disease.
    Annual review of nutrition, 2008, Volume: 28

    Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Humans; Liver Diseases; Liver Neoplasms

2008
The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.
    Advances in experimental medicine and biology, 1996, Volume: 399

    Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplas

1996
Labile methyl groups and the promotion of cancer.
    Annual review of nutrition, 1986, Volume: 6

    Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic

1986
Involvement of water-soluble vitamins in diseases of swine.
    Journal of animal science, 1985, Volume: 60, Issue:6

    Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotin; Choline; Choline Deficiency; Folic Acid; F

1985

Trials

6 trials available for choline and Folic Acid Deficiency

ArticleYear
Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:10

    Topics: Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Genotype; Humans; Lactation; Meth

2016
Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men.
    The Journal of nutrition, 2010, Volume: 140, Issue:5

    Topics: Adolescent; Adult; Choline; Choline Deficiency; Diet; DNA Damage; DNA Methylation; Dose-Response Rel

2010
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.
    The American journal of clinical nutrition, 2011, Volume: 93, Issue:2

    Topics: Adolescent; Adult; Betaine; Choline; Deuterium; Dietary Supplements; Folic Acid Deficiency; Genotype

2011
Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype.
    The Journal of nutrition, 2008, Volume: 138, Issue:1

    Topics: Adult; Choline; Diet; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Genetic V

2008
In vivo methylation capacity is not impaired in healthy men during short-term dietary folate and methyl group restriction.
    The Journal of nutrition, 1995, Volume: 125, Issue:6

    Topics: Administration, Oral; Adult; Carnitine; Choline; Choline Deficiency; Creatinine; Cross-Over Studies;

1995
Folate nutriture alters choline status of women and men fed low choline diets.
    The Journal of nutrition, 1999, Volume: 129, Issue:3

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Choline; Female; Folic Acid; Folic Acid De

1999

Other Studies

39 other studies available for choline and Folic Acid Deficiency

ArticleYear
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics.
    Molecular nutrition & food research, 2021, Volume: 65, Issue:9

    Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Kynurenine; Male; Methionine; Methylati

2021
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:6

    Topics: Animals; Carbon; Choline; Choline Deficiency; Cystathionine beta-Synthase; Disease Models, Animal; D

2013
In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.
    The Journal of biological chemistry, 2015, Jan-23, Volume: 290, Issue:4

    Topics: Animals; Choline; Dimethylglycine Dehydrogenase; Folic Acid; Folic Acid Deficiency; Formaldehyde; Fo

2015
Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus.
    Genes, brain, and behavior, 2015, Volume: 14, Issue:3

    Topics: Age Factors; Animals; Choline; Choline Deficiency; Diet; DNA Methylation; Epigenesis, Genetic; Folic

2015
Interaction between cytotoxic effects of gamma-radiation and folate deficiency in relation to choline reserves.
    Toxicology, 2009, Jan-08, Volume: 255, Issue:1-2

    Topics: Alanine Transaminase; Alcohol Oxidoreductases; Animals; Brain Chemistry; Choline; DNA; DNA Damage; D

2009
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.
    Journal of the American Dietetic Association, 2009, Volume: 109, Issue:2

    Topics: Adolescent; Adult; Biomarkers; Choline; Dose-Response Relationship, Drug; Female; Folic Acid; Folic

2009
Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain.
    The Journal of nutrition, 2010, Volume: 140, Issue:6

    Topics: Animals; Apoptosis; Brain; Choline; Female; Fetus; Folic Acid Deficiency; Mice; Mice, Inbred C57BL;

2010
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.
    The Journal of nutrition, 2010, Volume: 140, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-

2010
Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.
    Nutrition research (New York, N.Y.), 2010, Volume: 30, Issue:10

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline Deficiency; Diet; Dopamine; Folic Acid; Folic

2010
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
    The American journal of clinical nutrition, 2011, Volume: 93, Issue:4

    Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Def

2011
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:1

    Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Energy Intake; Folic Acid; Folic

2012
Folate-responsive birth defects: of mice and women.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:1

    Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyl

2012
Methylation capacity in children with severe cerebral palsy.
    European journal of clinical investigation, 2012, Volume: 42, Issue:7

    Topics: Betaine; Biomarkers; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Choline; Cystath

2012
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:4

    Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Emb

2012
Choline and/or folic acid deficiency is associated with genomic damage and cell death in human lymphocytes in vitro.
    Nutrition and cancer, 2012, Volume: 64, Issue:3

    Topics: Adult; Apoptosis; Cell Death; Cell Nucleus; Cells, Cultured; Choline; Choline Deficiency; DNA Damage

2012
Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats.
    The British journal of nutrition, 2013, Feb-28, Volume: 109, Issue:4

    Topics: Alkaline Phosphatase; Animal Feed; Animals; Apoptosis; beta Catenin; Cadherins; Caspase 3; Cell Diff

2013
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:11

    Topics: Animal Feed; Animals; Choline; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; DNA Damage;

2012
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:4

    Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo

2013
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
    The Journal of nutrition, 2013, Volume: 143, Issue:1

    Topics: Animals; Biomarkers; Choline; Cysteine; Disease Models, Animal; Folic Acid Deficiency; Heterozygote;

2013
The synthesis of choline and creatine in rats under various dietary conditions.
    The Journal of biological chemistry, 1953, Volume: 201, Issue:1

    Topics: Animals; Choline; Creatine; Creatinine; Diet; Folic Acid; Folic Acid Deficiency; Rats; Vitamin B 12

1953
The effect of folic acid deficiency on the metabolism of choline by chick bone marrow.
    The Journal of biological chemistry, 1954, Volume: 209, Issue:2

    Topics: Animals; Bone Marrow; Chickens; Choline; Folic Acid; Folic Acid Deficiency; Humans

1954
Vitamin B12 and folic acid in relation to methionine synthesis from betaine in vivo and invitro.
    The Journal of biological chemistry, 1957, Volume: 226, Issue:1

    Topics: Betaine; Choline; Folic Acid; Folic Acid Deficiency; Humans; Methionine; Vitamin B 12; Vitamin B 12

1957
Effect of dietary deficiencies of folic acid and choline on lipid metabolism in the rat.
    The Indian journal of medical research, 1960, Volume: 48

    Topics: Animals; Choline; Choline Deficiency; Folic Acid; Folic Acid Deficiency; Lipid Metabolism; Lipids; R

1960
FOLIC ACID DEFICIENCY AND HEMOCHROMATOSIS.
    Archives of pathology, 1965, Volume: 80

    Topics: Blood Chemical Analysis; Choline; Diet; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemochromatos

1965
Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus.
    The British journal of nutrition, 2007, Volume: 97, Issue:6

    Topics: Amino Acids; Animals; Choline; Diet; DNA Methylation; Female; Fetus; Folic Acid; Folic Acid Deficien

2007
Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection.
    Journal of the National Cancer Institute, 1984, Volume: 73, Issue:6

    Topics: Animals; Body Weight; Choline; Diet; Diethylnitrosamine; Drug Synergism; Folic Acid Deficiency; Live

1984
Modulation of expression of fos and Ha-ras oncogenes and ornithine decarboxylase activity in mammary gland and liver of young female rats by the absence of dietary lipotropes.
    Journal of dairy science, 1994, Volume: 77, Issue:8

    Topics: Animals; Choline; Choline Deficiency; Diet; Female; Folic Acid; Folic Acid Deficiency; Gene Expressi

1994
Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver.
    The Journal of nutrition, 1994, Volume: 124, Issue:11

    Topics: Animals; Body Weight; Choline; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; P

1994
Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction.
    The Journal of nutrition, 1994, Volume: 124, Issue:7

    Topics: Adult; Choline; Diet; Folic Acid; Folic Acid Deficiency; Glycine max; Homocysteine; Humans; Male; Me

1994
Workshop on Folate, B12, and Choline. Sponsored by the Panel on Folate and other B vitamins of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Washington, D.C., March 3-4,
    Nutrition (Burbank, Los Angeles County, Calif.), 1999, Volume: 15, Issue:1

    Topics: Biological Availability; Biomarkers; Cardiovascular Diseases; Choline; Congenital Abnormalities; Fem

1999
A methionine-reversible folate deficiency in rats following the acute administration of diethylnitrosamine and alpha-naphthylisothiocyanate.
    Chemico-biological interactions, 1977, Volume: 17, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Choline; Diet; Diethylnitrosamine; Folic Acid; Folic Acid Deficie

1977
[Treatment of vitamin B 12 deficiency].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1977, Jul-20, Volume: 53, Issue:20

    Topics: Arginine; Aspartic Acid; Choline; Drug Combinations; Folic Acid; Folic Acid Deficiency; Humans; Inje

1977
Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid.
    Carcinogenesis, 1992, Volume: 13, Issue:12

    Topics: Animals; Choline; Choline Deficiency; Chromatography, High Pressure Liquid; Diet; Folic Acid; Folic

1992
Folate deficiency in chicks fed diets containing practical ingredients.
    Poultry science, 1991, Volume: 70, Issue:3

    Topics: Animal Feed; Animals; Chickens; Choline; Folic Acid; Folic Acid Deficiency; Glycine max; Liver; Male

1991
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Animals; Choline; Choline Deficiency; Deoxyuridine; Diet; DNA Damage; DNA Replication; Folic Acid; F

1989
Folate deficiency and formiminoglutamic acid excretion during chronic diethylnitrosamine administration to rats.
    Cancer research, 1973, Volume: 33, Issue:2

    Topics: Animals; Betaine; Carcinogens; Choline; Diet; Drinking; FIGLU Test; Folic Acid; Folic Acid Deficienc

1973
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
    Cancer research, 1973, Volume: 33, Issue:9

    Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic

1973
Relationship of arginine and methionine to creatine formation in chicks.
    The Journal of nutrition, 1971, Volume: 101, Issue:7

    Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Arginine; Betaine; Body Weight; Ch

1971
Folacin requirements of turkey breeder hens.
    Poultry science, 1967, Volume: 46, Issue:6

    Topics: Animals; Choline; Female; Fertility; Folic Acid Deficiency; Glycine max; Poultry Diseases; Turkeys

1967