choline has been researched along with Folic Acid Deficiency in 51 studies
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
Excerpt | Relevance | Reference |
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"Adequate choline intake during pregnancy is essential for proper fetal development." | 8.91 | [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. ( Drews, K, 2015) |
"Severe choline deficiency adversely affects cellular methylation and DNA integrity, with potentially serious implications for disease risk." | 5.14 | Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men. ( Abratte, CM; Caudill, MA; Shin, W; Vermeylen, F; Yan, J, 2010) |
"Adequate choline intake during pregnancy is essential for proper fetal development." | 4.91 | [Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. ( Drews, K, 2015) |
"To dissociate the effects of dietary folate and choline deficiency on Shmt1-related NTD sensitivity, we determined NTD incidence in embryos from Shmt1-null dams fed diets deficient in either folate or choline." | 3.78 | Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. ( Abarinov, EV; Beaudin, AE; Caudill, M; Malysheva, O; Perry, CA; Stover, PJ, 2012) |
"Reduced folate and choline status resulted in severe fetal growth restriction (FGR) and impaired fertility in litters harvested from Mthfd1(gt/+) dams, but embryonic Mthfd1(gt/+) genotype did not affect fetal growth." | 3.78 | Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. ( Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ, 2012) |
"We examined whether genetic disruption of the Shmt1 gene in mice induces NTDs in response to maternal folate and choline deficiency and whether a corresponding disruption in de novo thymidylate biosynthesis underlies NTD pathogenesis." | 3.77 | Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. ( Abarinov, EV; Allen, RH; Beaudin, AE; Chu, S; Noden, DM; Perry, CA; Stabler, SP; Stover, PJ, 2011) |
" Folic acid deficiency, as indicated by retarded growth and feed efficiency, could be produced in 18-day-old chicks." | 3.68 | Folate deficiency in chicks fed diets containing practical ingredients. ( Pesti, GM; Rowland, GN; Ryu, KS, 1991) |
" Each of 50 rats per group received one injection 20 mg diethylnitrosamine [(DENA) CAS: 55-18-5; N-nitrosodiethylamine]/kg body weight at 4 weeks of age, and then each was maintained on a methyl group-adequate (MA) diet for 52 weeks (groups 2 and 5) or on an MD diet for 15 weeks followed by the MA diet for 37 weeks (group 4)." | 3.67 | Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection. ( Hoover, KL; Lynch, PH; Poirier, LA, 1984) |
" Later work indicated that in rats and mice, diets deficient in labile methyl groups (choline, methionine, betaine, folate) produced fatty liver and that long-term administration of diets deficient in choline and methionine also caused hepatocellular carcinoma." | 2.44 | Methionine metabolism and liver disease. ( Lu, SC; Martínez-Chantar, ML; Mato, JM, 2008) |
" Previous studies have shown that the long-term administration of a diet lacking essential one-carbon nutrients such as methionine, choline and folic acid (methyl donors) caused global DNA hypermethylation in the brain." | 1.42 | Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus. ( Ishii, D; Kawai, K; Mashimo, Y; Matsuda, S; Matsuzawa, D; Shimizu, E; Sutoh, C; Tomizawa, H, 2015) |
"Choline is a required nutrient with roles in liver and brain function, lipid metabolism, and fetal development." | 1.35 | Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. ( Caudill, MA; Hinkis, S; Ivanov, A; Nash-Barboza, S, 2009) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (29.41) | 18.7374 |
1990's | 9 (17.65) | 18.2507 |
2000's | 6 (11.76) | 29.6817 |
2010's | 20 (39.22) | 24.3611 |
2020's | 1 (1.96) | 2.80 |
Authors | Studies |
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Tillmann, S | 1 |
Awwad, HM | 1 |
MacPherson, CW | 1 |
Happ, DF | 1 |
Treccani, G | 1 |
Geisel, J | 1 |
Tompkins, TA | 1 |
Ueland, PM | 1 |
Wegener, G | 1 |
Obeid, R | 2 |
Pogribny, IP | 2 |
Kutanzi, K | 2 |
Melnyk, S | 2 |
de Conti, A | 2 |
Tryndyak, V | 2 |
Montgomery, B | 1 |
Pogribna, M | 1 |
Muskhelishvili, L | 1 |
Latendresse, JR | 2 |
James, SJ | 3 |
Beland, FA | 2 |
Rusyn, I | 2 |
Morrow, GP | 1 |
MacMillan, L | 1 |
Lamarre, SG | 1 |
Young, SK | 1 |
MacFarlane, AJ | 1 |
Brosnan, ME | 1 |
Brosnan, JT | 1 |
Tomizawa, H | 1 |
Matsuzawa, D | 1 |
Ishii, D | 1 |
Matsuda, S | 1 |
Kawai, K | 1 |
Mashimo, Y | 1 |
Sutoh, C | 1 |
Shimizu, E | 1 |
Drews, K | 1 |
Ganz, AB | 1 |
Shields, K | 1 |
Fomin, VG | 1 |
Lopez, YS | 1 |
Mohan, S | 1 |
Lovesky, J | 1 |
Chuang, JC | 1 |
Ganti, A | 1 |
Carrier, B | 1 |
Yan, J | 3 |
Taeswuan, S | 1 |
Cohen, VV | 1 |
Swersky, CC | 1 |
Stover, JA | 1 |
Vitiello, GA | 1 |
Malysheva, OV | 2 |
Mudrak, E | 1 |
Caudill, MA | 7 |
Batra, V | 1 |
Devasagayam, TP | 1 |
Ivanov, A | 1 |
Nash-Barboza, S | 1 |
Hinkis, S | 1 |
Shin, W | 1 |
Abratte, CM | 1 |
Vermeylen, F | 1 |
Craciunescu, CN | 1 |
Johnson, AR | 1 |
Zeisel, SH | 2 |
Christensen, KE | 1 |
Wu, Q | 2 |
Wang, X | 2 |
Deng, L | 1 |
Rozen, R | 2 |
Crivello, NA | 1 |
Blusztajn, JK | 1 |
Joseph, JA | 1 |
Shukitt-Hale, B | 1 |
Smith, DE | 1 |
Wang, W | 2 |
Gregory, JF | 1 |
Malysheva, O | 2 |
Brenna, JT | 1 |
Stabler, SP | 4 |
Allen, RH | 4 |
Beaudin, AE | 3 |
Abarinov, EV | 3 |
Noden, DM | 1 |
Perry, CA | 3 |
Chu, S | 1 |
Stover, PJ | 4 |
Caudill, M | 2 |
Shane, B | 1 |
Schoendorfer, NC | 1 |
Moxon-Lester, L | 1 |
Sharp, N | 1 |
Vitetta, L | 1 |
Boyd, RN | 1 |
Davies, PS | 1 |
Lu, L | 1 |
Ni, J | 1 |
Zhou, T | 1 |
Xu, W | 1 |
Fenech, M | 1 |
Bressenot, A | 1 |
Pooya, S | 1 |
Bossenmeyer-Pourie, C | 1 |
Gauchotte, G | 1 |
Germain, A | 1 |
Chevaux, JB | 1 |
Coste, F | 1 |
Vignaud, JM | 1 |
Guéant, JL | 2 |
Peyrin-Biroulet, L | 1 |
Kobets, T | 1 |
Koturbash, I | 1 |
Han, T | 1 |
Fuscoe, JC | 1 |
Shymonyak, S | 1 |
Collins, L | 1 |
Ross, SA | 1 |
Mikael, LG | 1 |
Pancer, J | 1 |
Jiang, X | 1 |
Field, MS | 1 |
Shields, KS | 1 |
Ash, JA | 1 |
Strupp, BJ | 1 |
Brunaud, L | 1 |
Alberto, JM | 1 |
Ayav, A | 1 |
Gérard, P | 1 |
Namour, F | 1 |
Antunes, L | 1 |
Braun, M | 1 |
Bronowicki, JP | 1 |
Bresler, L | 1 |
STEKOL, JA | 2 |
WEISS, S | 2 |
SMITH, P | 1 |
WEISS, K | 1 |
DINNING, JS | 1 |
NEATROUR, R | 1 |
DAY, PL | 1 |
ANDERSON, EI | 1 |
HSU, PT | 1 |
WATJEN, A | 1 |
DALAL, FR | 1 |
FATTERPAKER, P | 1 |
REGE, DV | 1 |
SREENIVASAN, A | 1 |
MACDONALD, RA | 1 |
JONES, RS | 1 |
PECHET, GS | 1 |
Maloney, CA | 1 |
Hay, SM | 1 |
Rees, WD | 1 |
Solis, C | 1 |
Veenema, K | 1 |
Ivanov, AA | 1 |
Tran, S | 1 |
Li, R | 1 |
Moriarty, DJ | 1 |
Maletz, CV | 1 |
Mato, JM | 1 |
Martínez-Chantar, ML | 1 |
Lu, SC | 1 |
Hoover, KL | 1 |
Lynch, PH | 1 |
Poirier, LA | 4 |
Jacob, RA | 3 |
Pianalto, FS | 1 |
Henning, SM | 3 |
Zhang, JZ | 1 |
Swendseid, ME | 4 |
Park, CS | 1 |
Choi, CB | 1 |
Baik, MG | 1 |
Keller, WL | 1 |
Kim, YI | 1 |
Miller, JW | 1 |
da Costa, KA | 1 |
Nadeau, M | 1 |
Smith, D | 1 |
Selhub, J | 1 |
Mason, JB | 1 |
Wu, MM | 1 |
Glade, MJ | 1 |
Jenden, DJ | 1 |
Allman-Farinelli, MA | 1 |
Petri, WA | 1 |
Asoklis, K | 1 |
Asoklis, R | 1 |
Cross, DR | 1 |
Miller, BJ | 1 |
Pesti, GM | 1 |
Rowland, GN | 1 |
Ryu, KS | 1 |
Newberne, PM | 1 |
Rogers, AE | 1 |
Yin, L | 1 |
Blair, R | 1 |
Newsome, F | 1 |
Whitehead, VM | 1 |
Keshavarz, K | 1 |
Fuller, HL | 1 |
Miller, DL | 1 |
Balloun, SL | 1 |
6 reviews available for choline and Folic Acid Deficiency
Article | Year |
---|---|
[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy].
Topics: Choline; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Humans; Maternal Nutritiona | 2015 |
Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diet; DNA Methylation; Folic Acid Deficiency; Gas | 2003 |
Methionine metabolism and liver disease.
Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Humans; Liver Diseases; Liver Neoplasms | 2008 |
The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.
Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplas | 1996 |
Labile methyl groups and the promotion of cancer.
Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic | 1986 |
Involvement of water-soluble vitamins in diseases of swine.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotin; Choline; Choline Deficiency; Folic Acid; F | 1985 |
6 trials available for choline and Folic Acid Deficiency
Article | Year |
---|---|
Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.
Topics: Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Genotype; Humans; Lactation; Meth | 2016 |
Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men.
Topics: Adolescent; Adult; Choline; Choline Deficiency; Diet; DNA Damage; DNA Methylation; Dose-Response Rel | 2010 |
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.
Topics: Adolescent; Adult; Betaine; Choline; Deuterium; Dietary Supplements; Folic Acid Deficiency; Genotype | 2011 |
Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype.
Topics: Adult; Choline; Diet; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Genetic V | 2008 |
In vivo methylation capacity is not impaired in healthy men during short-term dietary folate and methyl group restriction.
Topics: Administration, Oral; Adult; Carnitine; Choline; Choline Deficiency; Creatinine; Cross-Over Studies; | 1995 |
Folate nutriture alters choline status of women and men fed low choline diets.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Choline; Female; Folic Acid; Folic Acid De | 1999 |
39 other studies available for choline and Folic Acid Deficiency
Article | Year |
---|---|
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics.
Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Kynurenine; Male; Methionine; Methylati | 2021 |
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.
Topics: Animals; Carbon; Choline; Choline Deficiency; Cystathionine beta-Synthase; Disease Models, Animal; D | 2013 |
In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.
Topics: Animals; Choline; Dimethylglycine Dehydrogenase; Folic Acid; Folic Acid Deficiency; Formaldehyde; Fo | 2015 |
Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Diet; DNA Methylation; Epigenesis, Genetic; Folic | 2015 |
Interaction between cytotoxic effects of gamma-radiation and folate deficiency in relation to choline reserves.
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Animals; Brain Chemistry; Choline; DNA; DNA Damage; D | 2009 |
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.
Topics: Adolescent; Adult; Biomarkers; Choline; Dose-Response Relationship, Drug; Female; Folic Acid; Folic | 2009 |
Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain.
Topics: Animals; Apoptosis; Brain; Choline; Female; Fetus; Folic Acid Deficiency; Mice; Mice, Inbred C57BL; | 2010 |
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S- | 2010 |
Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline Deficiency; Diet; Dopamine; Folic Acid; Folic | 2010 |
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Def | 2011 |
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Energy Intake; Folic Acid; Folic | 2012 |
Folate-responsive birth defects: of mice and women.
Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyl | 2012 |
Methylation capacity in children with severe cerebral palsy.
Topics: Betaine; Biomarkers; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Choline; Cystath | 2012 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Emb | 2012 |
Choline and/or folic acid deficiency is associated with genomic damage and cell death in human lymphocytes in vitro.
Topics: Adult; Apoptosis; Cell Death; Cell Nucleus; Cells, Cultured; Choline; Choline Deficiency; DNA Damage | 2012 |
Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats.
Topics: Alkaline Phosphatase; Animal Feed; Animals; Apoptosis; beta Catenin; Cadherins; Caspase 3; Cell Diff | 2013 |
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Topics: Animal Feed; Animals; Choline; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; DNA Damage; | 2012 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo | 2013 |
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Topics: Animals; Biomarkers; Choline; Cysteine; Disease Models, Animal; Folic Acid Deficiency; Heterozygote; | 2013 |
The synthesis of choline and creatine in rats under various dietary conditions.
Topics: Animals; Choline; Creatine; Creatinine; Diet; Folic Acid; Folic Acid Deficiency; Rats; Vitamin B 12 | 1953 |
The effect of folic acid deficiency on the metabolism of choline by chick bone marrow.
Topics: Animals; Bone Marrow; Chickens; Choline; Folic Acid; Folic Acid Deficiency; Humans | 1954 |
Vitamin B12 and folic acid in relation to methionine synthesis from betaine in vivo and invitro.
Topics: Betaine; Choline; Folic Acid; Folic Acid Deficiency; Humans; Methionine; Vitamin B 12; Vitamin B 12 | 1957 |
Effect of dietary deficiencies of folic acid and choline on lipid metabolism in the rat.
Topics: Animals; Choline; Choline Deficiency; Folic Acid; Folic Acid Deficiency; Lipid Metabolism; Lipids; R | 1960 |
FOLIC ACID DEFICIENCY AND HEMOCHROMATOSIS.
Topics: Blood Chemical Analysis; Choline; Diet; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemochromatos | 1965 |
Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus.
Topics: Amino Acids; Animals; Choline; Diet; DNA Methylation; Female; Fetus; Folic Acid; Folic Acid Deficien | 2007 |
Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection.
Topics: Animals; Body Weight; Choline; Diet; Diethylnitrosamine; Drug Synergism; Folic Acid Deficiency; Live | 1984 |
Modulation of expression of fos and Ha-ras oncogenes and ornithine decarboxylase activity in mammary gland and liver of young female rats by the absence of dietary lipotropes.
Topics: Animals; Choline; Choline Deficiency; Diet; Female; Folic Acid; Folic Acid Deficiency; Gene Expressi | 1994 |
Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver.
Topics: Animals; Body Weight; Choline; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; P | 1994 |
Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction.
Topics: Adult; Choline; Diet; Folic Acid; Folic Acid Deficiency; Glycine max; Homocysteine; Humans; Male; Me | 1994 |
Workshop on Folate, B12, and Choline. Sponsored by the Panel on Folate and other B vitamins of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Washington, D.C., March 3-4,
Topics: Biological Availability; Biomarkers; Cardiovascular Diseases; Choline; Congenital Abnormalities; Fem | 1999 |
A methionine-reversible folate deficiency in rats following the acute administration of diethylnitrosamine and alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Animals; Choline; Diet; Diethylnitrosamine; Folic Acid; Folic Acid Deficie | 1977 |
[Treatment of vitamin B 12 deficiency].
Topics: Arginine; Aspartic Acid; Choline; Drug Combinations; Folic Acid; Folic Acid Deficiency; Humans; Inje | 1977 |
Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid.
Topics: Animals; Choline; Choline Deficiency; Chromatography, High Pressure Liquid; Diet; Folic Acid; Folic | 1992 |
Folate deficiency in chicks fed diets containing practical ingredients.
Topics: Animal Feed; Animals; Chickens; Choline; Folic Acid; Folic Acid Deficiency; Glycine max; Liver; Male | 1991 |
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Deoxyuridine; Diet; DNA Damage; DNA Replication; Folic Acid; F | 1989 |
Folate deficiency and formiminoglutamic acid excretion during chronic diethylnitrosamine administration to rats.
Topics: Animals; Betaine; Carcinogens; Choline; Diet; Drinking; FIGLU Test; Folic Acid; Folic Acid Deficienc | 1973 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic | 1973 |
Relationship of arginine and methionine to creatine formation in chicks.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Arginine; Betaine; Body Weight; Ch | 1971 |
Folacin requirements of turkey breeder hens.
Topics: Animals; Choline; Female; Fertility; Folic Acid Deficiency; Glycine max; Poultry Diseases; Turkeys | 1967 |