choline has been researched along with Experimental Hepatoma in 38 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 5.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| "To compare metabolic magnetic resonance (MR) imaging findings (ie, quantification of tumor choline concentration) with percentage of necrosis on pathologic examination in rabbits bearing VX2 liver tumors." | 3.77 | Quantitative proton MR spectroscopy as a biomarker of tumor necrosis in the rabbit VX2 liver tumor. ( Buijs, M; Geschwind, JF; Kamel, IR; Lee, KH; Liapi, E; Pan, L; Salibi, N; Ventura, VP; Vossen, JA, 2011) |
| "We evaluated the effects of angiogenesis inhibitor, TNP-470, on hepatocellular carcinoma (HCCs) induced by a choline-deficient L-amino acid defined (CDAA) diet in rats." | 3.70 | Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats. ( Kin, M; Nakamura, T; Ogata, R; Sakamoto, M; Sata, M; Tamaki, S; Torimura, T; Ueno, T, 2000) |
| "Effects of inhibitors of arachidonic acid (AA) metabolism on the development of fatty liver, cirrhosis, glutathione-S-transferase placental form (GST-P)-positive nodules and the generation of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances (TBARS), caused by a choline-deficient, L-amino acid-defined (CDAA) diet, were examined in male Fischer 344 rats by feeding CDAA diets supplemented with the inhibitors for 12 and 30 weeks." | 3.69 | Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. ( Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T, 1996) |
| "Choline deficiency, via deprivation of labile methyl groups, is associated with a greatly increased incidence of hepatocarcinoma in experimental animals." | 3.68 | Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. ( Blusztajn, JK; Cochary, EF; da Costa, KA; Garner, SC; Zeisel, SH, 1993) |
| " Each of 50 rats per group received one injection 20 mg diethylnitrosamine [(DENA) CAS: 55-18-5; N-nitrosodiethylamine]/kg body weight at 4 weeks of age, and then each was maintained on a methyl group-adequate (MA) diet for 52 weeks (groups 2 and 5) or on an MD diet for 15 weeks followed by the MA diet for 37 weeks (group 4)." | 3.67 | Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection. ( Hoover, KL; Lynch, PH; Poirier, LA, 1984) |
| "Choline deficiency has been well studied in the context of liver disease; however, less is known about the effects of choline supplementation in HCC." | 1.56 | Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. ( Allende, DS; Brown, AL; Conrad, K; Gromovsky, AD; Helsley, RN; Neumann, CK; Owens, AP; Tranter, M; Zhang, R, 2020) |
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 1.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (39.47) | 18.7374 |
| 1990's | 15 (39.47) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, AL | 1 |
| Conrad, K | 1 |
| Allende, DS | 1 |
| Gromovsky, AD | 1 |
| Zhang, R | 1 |
| Neumann, CK | 1 |
| Owens, AP | 1 |
| Tranter, M | 1 |
| Helsley, RN | 1 |
| Li, Y | 1 |
| Lin, D | 1 |
| Weng, Y | 1 |
| Weng, S | 1 |
| Yan, C | 1 |
| Xu, X | 1 |
| Chen, J | 1 |
| Ye, R | 1 |
| Hong, J | 1 |
| Knight, B | 1 |
| Tirnitz-Parker, JE | 1 |
| Olynyk, JK | 1 |
| Buijs, M | 1 |
| Vossen, JA | 1 |
| Geschwind, JF | 1 |
| Salibi, N | 1 |
| Pan, L | 1 |
| Ventura, VP | 1 |
| Liapi, E | 1 |
| Lee, KH | 1 |
| Kamel, IR | 1 |
| Brunaud, L | 1 |
| Alberto, JM | 1 |
| Ayav, A | 1 |
| Gérard, P | 1 |
| Namour, F | 1 |
| Antunes, L | 1 |
| Braun, M | 1 |
| Bronowicki, JP | 1 |
| Bresler, L | 1 |
| Guéant, JL | 1 |
| SALMON, WD | 1 |
| COPELAND, DH | 1 |
| BURNS, MJ | 1 |
| KENSLER, CJ | 1 |
| BIERMAN, E | 1 |
| CONDOURIS, G | 1 |
| SCHOENTAL, R | 1 |
| HEAD, MA | 1 |
| SCHNEIDER, WC | 1 |
| ROTHERHAM, J | 1 |
| HARTROFT, WS | 1 |
| Tesiram, YA | 1 |
| Saunders, D | 1 |
| Towner, RA | 1 |
| Kubota, K | 1 |
| Soeda, J | 1 |
| Misawa, R | 1 |
| Mihara, M | 1 |
| Miwa, S | 1 |
| Ise, H | 1 |
| Takahashi, M | 1 |
| Miyagawa, S | 1 |
| Shinozuka, H | 3 |
| Abanobi, SE | 1 |
| Lombardi, B | 6 |
| Hoover, KL | 1 |
| Lynch, PH | 1 |
| Poirier, LA | 2 |
| Rogers, AE | 1 |
| Lenhart, G | 1 |
| Morrison, G | 1 |
| da Costa, KA | 2 |
| Garner, SC | 2 |
| Chang, J | 1 |
| Zeisel, SH | 2 |
| Cochary, EF | 1 |
| Blusztajn, JK | 1 |
| Yoshida, LS | 1 |
| Miyazawa, T | 1 |
| Hatayama, I | 1 |
| Sato, K | 1 |
| Fujimoto, K | 1 |
| Kaneda, T | 1 |
| Cui, Z | 1 |
| Houweling, M | 1 |
| Vance, DE | 1 |
| Endoh, T | 1 |
| Tang, Q | 1 |
| Denda, A | 2 |
| Noguchi, O | 1 |
| Kobayashi, E | 1 |
| Tamura, K | 1 |
| Horiguchi, K | 1 |
| Ogasawara, H | 1 |
| Tsujiuchi, T | 2 |
| Nakae, D | 2 |
| Sugimura, M | 1 |
| Konishi, Y | 2 |
| Kobayashi, Y | 1 |
| Akai, H | 1 |
| Kishida, H | 1 |
| Okajima, E | 1 |
| Kitayama, W | 1 |
| Murakami, A | 1 |
| Koshimizu, K | 1 |
| Ohigashi, H | 1 |
| Kin, M | 1 |
| Torimura, T | 1 |
| Ueno, T | 1 |
| Nakamura, T | 1 |
| Ogata, R | 1 |
| Sakamoto, M | 1 |
| Tamaki, S | 1 |
| Sata, M | 1 |
| Takahashi, S | 1 |
| Katyal, SL | 1 |
| Sell, S | 1 |
| Iammarino, RM | 1 |
| Hacker, HJ | 1 |
| Steinberg, P | 1 |
| Toshkov, I | 1 |
| Oesch, F | 1 |
| Bannasch, P | 1 |
| Tessitore, L | 2 |
| Pani, P | 2 |
| Dianzani, MU | 2 |
| Mirowski, M | 1 |
| Hanausek, M | 1 |
| Sherman, U | 1 |
| Adams, AK | 1 |
| Walaszek, Z | 1 |
| Slaga, TJ | 1 |
| Locker, J | 1 |
| Saito, R | 1 |
| Palomba, L | 1 |
| Rao, KN | 1 |
| Newberne, PM | 1 |
| Suphiphat, V | 1 |
| Locniskar, M | 1 |
| de Camargo, JL | 1 |
| Datko, AH | 1 |
| Aksamit, RR | 1 |
| Mudd, SH | 1 |
| Fullerton, FR | 1 |
| Hoover, K | 1 |
| Mikol, YB | 1 |
| Creasia, DA | 1 |
| Chandar, N | 1 |
| Eppler, CM | 1 |
| Malewicz, B | 1 |
| Jenkin, HM | 1 |
| Baumann, WJ | 1 |
| Wainfan, E | 1 |
| Dizik, M | 1 |
| Yamamoto, K | 1 |
| Niwa, A | 1 |
| Yasumura, Y | 1 |
| Ove, P | 1 |
| Reddy, TV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for choline and Experimental Hepatoma
| Article | Year |
|---|---|
Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diet; DNA Methylation; Folic Acid Deficiency; Gas | 2003 |
Gene amplification during stages of carcinogenesis.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Choline; Cocarcinogenesis; Diet; Gene Ampli | 1991 |
36 other studies available for choline and Experimental Hepatoma
| Article | Year |
|---|---|
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice.
Topics: Animals; Betaine; Choline; Diet, High-Fat; Dietary Supplements; DNA, Mitochondrial; Fatty Liver; Gen | 2020 |
Early Diffusion-Weighted Imaging and Proton Magnetic Resonance Spectroscopy Features of Liver Transplanted Tumors Treated with Radiation in Rabbits: Correlation with Histopathology.
Topics: Animals; bcl-2-Associated X Protein; Choline; Creatinine; Diffusion; Diffusion Magnetic Resonance Im | 2019 |
C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cho | 2008 |
Quantitative proton MR spectroscopy as a biomarker of tumor necrosis in the rabbit VX2 liver tumor.
Topics: Animals; Choline; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Necrosis; Rabbits; | 2011 |
Hepatomas in choline deficiency.
Topics: Animals; Carcinoma, Hepatocellular; Choline; Choline Deficiency; Humans; Liver Neoplasms; Liver Neop | 1955 |
The effects of compounds related to choline on azo-dye carcinogenesis.
Topics: Amino Alcohols; Animals; Benzene; Benzene Derivatives; Carcinogenesis; Carcinoma, Hepatocellular; Ch | 1955 |
Progression of liver lesions produced in rats by temporary treatment with pyrrolizidine (senecio) alkaloids, and the effects of betaine and high casein diet.
Topics: Animals; Betaine; Caseins; Choline; Diet; Disease Progression; Gastrointestinal Diseases; Liver Neop | 1957 |
Phosphorus compounds in animal tissues. VI. Deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine in the Novikoff hepatoma.
Topics: Animals; Choline; Deoxycytosine Nucleotides; Encephalomyelitis; Ethanolamine; Ethanolamines; Liver N | 1958 |
Hepatic cancer. Nutritional factors and the production by dietary choline deficiency of cancer de novo in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Liver Neoplasms, Experimental; Mice | 1959 |
Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model.
Topics: Animals; Choline; Choline Deficiency; Deuterium; Diet; Disease Models, Animal; Fatty Liver; Lipid Me | 2005 |
Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model.
Topics: Animal Feed; Animals; Bone Marrow Cells; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2008 |
Modulation of tumor promotion in liver carcinogenesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Di | 1983 |
Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection.
Topics: Animals; Body Weight; Choline; Diet; Diethylnitrosamine; Drug Synergism; Folic Acid Deficiency; Live | 1984 |
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethy | 1980 |
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
Topics: Aging; Animals; Cell Membrane; Choline; Choline Deficiency; Diglycerides; Fatty Acids; gamma-Glutamy | 1995 |
Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats.
Topics: Animals; Blotting, Western; Cell Membrane; Choline; Choline Deficiency; Diet; Diglycerides; Fatty Li | 1993 |
Phosphatidylcholine peroxidation and liver cancer in mice fed a choline-deficient diet with ethionine.
Topics: Animals; Body Weight; Choline; Choline Deficiency; Diet; Ethionine; Glutathione Transferase; Isoenzy | 1993 |
Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.
Topics: Animals; Cell Division; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Cholin | 1995 |
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver | 1996 |
Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.
Topics: Amino Acids; Animals; Anticarcinogenic Agents; Benzyl Alcohols; Carcinogens; Choline; Diet; Diethyln | 1998 |
Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Hepatocellular; Choline; Cyclohexanes; Diet; | 2000 |
Induction of foci of altered hepatocytes by a single injection of azaserine to rats.
Topics: 2-Acetylaminofluorene; Animals; Azaserine; Choline; Cocarcinogenesis; gamma-Glutamyltransferase; Liv | 1979 |
Enhancement of DL-ethionine-induced liver carcinogenesis in rats fed a choline-devoid diet.
Topics: Animals; Choline; Choline Deficiency; Diet; Ethionine; Liver Neoplasms, Experimental; Male; Rats | 1978 |
Persistence of the cholangiocellular and hepatocellular lesions observed in rats fed a choline-deficient/DL-ethionine-supplemented diet.
Topics: Adenoma, Bile Duct; Animals; Bile Duct Neoplasms; Choline; Ethionine; Immunoenzyme Techniques; Liver | 1992 |
Mechanisms of the enhanced liver carcinogenesis by choline in female rats: delay in liver growth after partial hepatectomy and stimulation of 2-AAF mitoinhibition.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline; Diethylnitrosamine; DNA, Neoplasm; Drug Inte | 1992 |
An enzyme-linked immunosorbent assay for p65 oncofetal protein and its potential as a new marker for cancer risk assessment in rodents and humans.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Choline; Choline Deficiency; Diethylni | 1992 |
Choline enhances acetylaminofluorene promotion of liver carcinogenesis in female but not in male rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Choline; Diethylnitrosamine; Drug Synergism; F | 1992 |
Resistance of female Fischer-344 rats to the hepatonecrogenic and hepatocarcinogenic actions of a choline-devoid diet.
Topics: Animals; Choline; Diet; Female; Liver; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Exper | 1991 |
Inhibition of hepatocarcinogenesis in mice by dietary methyl donors methionine and choline.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Choline; Diet; Life Tables; Liver Neoplasms, Experim | 1990 |
Phosphatidylcholine synthesis in the rat: the substrate for methylation and regulation by choline.
Topics: Animals; Choline; Ethanolamines; Liver; Liver Neoplasms, Experimental; Male; Methionine; Methylation | 1990 |
The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital.
Topics: Animals; Choline; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; | 1990 |
Liver cell proliferation and incidence of hepatocellular carcinomas in rats fed consecutively a choline-devoid and a choline-supplemented diet.
Topics: Animals; Cell Division; Choline; Choline Deficiency; Diet; DNA, Neoplasm; Liver; Liver Neoplasms, Ex | 1988 |
Phosphatidylcholine as the choline donor in sphingomyelin synthesis.
Topics: Animals; Choline; Ethyl Ethers; Liver Neoplasms, Experimental; Phosphatidylcholines; Rats; Sphingomy | 1987 |
Suppression by methionine and choline of onco-fetal patterns of liver tRNA methyltransferase activities in carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Choline; Liver; Liver Neoplasms, Experimental; Male; Methionine; Rat | 1987 |
Continuous growth and phosphatidylcholine synthesis of rat hepatoma cells in choline-deprived chemically defined medium.
Topics: Animals; Cell Division; Cell Line; Choline; Chromosomes; Culture Media; Liver Neoplasms, Experimenta | 1985 |
Endogenous hepatic growth-modulating factors and effects of a choline-devoid diet and of phenobarbital on hepatocarcinogenesis in the rat.
Topics: Animals; Carbon Tetrachloride; Choline; Diet; DNA; Ethionine; Growth Substances; Liver; Liver Neopla | 1985 |