choline has been researched along with Epilepsy in 38 studies
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 7.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 7.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "Seizure-experienced Genetically Epilepsy-prone Rats (GEPRs) have increased acetylcholine content and choline acetyltransferase activity in the thalamus and striatum." | 7.67 | Abnormalities in the central cholinergic transmitter system of the genetically epilepsy-prone rat. ( Hadjiconstantinou, M; Laird, HE; Neff, NH, 1986) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 3.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 3.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "Metabolite maps of N-acetyl aspartate, choline and creatine were generated using (1)H-CSI data from the brain of healthy volunteers and patients with tumor and epilepsy." | 3.76 | Grid-free interactive and automated data processing for MR chemical shift imaging data. ( Confort-Gouny, S; Cozzone, PJ; Guye, M; Kober, F; Le Fur, Y; Nicoli, F, 2010) |
| "Seizure-experienced Genetically Epilepsy-prone Rats (GEPRs) have increased acetylcholine content and choline acetyltransferase activity in the thalamus and striatum." | 3.67 | Abnormalities in the central cholinergic transmitter system of the genetically epilepsy-prone rat. ( Hadjiconstantinou, M; Laird, HE; Neff, NH, 1986) |
| " Kainic acid (KA), a rigid structural analog of Glu, powerfully reproduces the excitatory neurotoxic (excitotoxic) action of Glu on central neurons and, in addition, causes sustained limbic seizures and a pattern of seizure-linked brain damage in rats that closely resembles that observed in human epilepsy." | 3.67 | Excitotoxic mechanisms of epileptic brain damage. ( Collins, RC; Olney, JW; Sloviter, RS, 1986) |
| "Choline is an essential nutrient for humans." | 2.49 | Neuroprotective actions of perinatal choline nutrition. ( Blusztajn, JK; Mellott, TJ, 2013) |
| "We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy." | 1.38 | Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease. ( Bunge, M; Mhanni, AA; Ryner, L; Salman, MS; Udow, S, 2012) |
| "Intracranial arachnoid cysts (ACs) are usually asymptomatic, benign developmental anomalies." | 1.35 | Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients. ( Ozcan, C; Ozisik, HI; Sarac, K, 2008) |
| "An association between complex febrile convulsions and the development of hippocampal atrophy, which is characterized by neuron loss and gliosis, has been suggested but is still controversial." | 1.30 | Proton spectroscopy in children with epilepsy and febrile convulsions. ( Holopainen, IE; Komu, ME; Lundbom, NM; Manner, TE; Sillanpää, ML; Sonninen, PH; Valtonen, ME, 1998) |
| "Physostigmine enhanced the increase in acetylcholine level but did not modify the time course nor the intensity of the convulsions." | 1.29 | Methionine sulfoximine increases acetylcholine level in the rat brain: no relation with epileptogenesis. ( Hevor, T; Richard, O, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (18.42) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 13 (34.21) | 29.6817 |
| 2010's | 11 (28.95) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Sakata, Y | 1 |
| Sano, K | 1 |
| Aoki, S | 1 |
| Saitsu, H | 1 |
| Takanashi, JI | 1 |
| Wu, HC | 1 |
| Dachet, F | 1 |
| Ghoddoussi, F | 1 |
| Bagla, S | 1 |
| Fuerst, D | 1 |
| Stanley, JA | 1 |
| Galloway, MP | 1 |
| Loeb, JA | 1 |
| Oya, M | 1 |
| Suzuki, H | 1 |
| Anas, ARJ | 1 |
| Oishi, K | 1 |
| Ono, K | 1 |
| Yamaguchi, S | 1 |
| Eguchi, M | 1 |
| Sawada, M | 1 |
| Rychikhin, VM | 1 |
| Sariev, AK | 1 |
| Pomytkin, IA | 1 |
| Tschampa, HJ | 1 |
| Urbach, H | 1 |
| Träber, F | 1 |
| Sprinkart, AM | 1 |
| Greschus, S | 1 |
| Malter, MP | 1 |
| Surges, R | 1 |
| Gieseke, J | 1 |
| Block, W | 1 |
| Matias, M | 1 |
| Silvestre, S | 1 |
| Falcao, A | 1 |
| Alves, G | 1 |
| Ozisik, HI | 1 |
| Sarac, K | 1 |
| Ozcan, C | 1 |
| Le Fur, Y | 1 |
| Nicoli, F | 1 |
| Guye, M | 1 |
| Confort-Gouny, S | 1 |
| Cozzone, PJ | 1 |
| Kober, F | 1 |
| Shao, XL | 1 |
| Zhou, ZS | 1 |
| Hong, W | 1 |
| Lee, EM | 1 |
| Park, GY | 1 |
| Im, KC | 1 |
| Kim, ST | 1 |
| Woo, CW | 1 |
| Chung, JH | 1 |
| Kim, KS | 1 |
| Kim, JS | 1 |
| Shon, YM | 1 |
| Kim, YI | 1 |
| Kang, JK | 1 |
| Motin, VG | 1 |
| Udow, S | 1 |
| Bunge, M | 1 |
| Ryner, L | 1 |
| Mhanni, AA | 1 |
| Salman, MS | 1 |
| Blusztajn, JK | 1 |
| Mellott, TJ | 1 |
| Ziyeh, S | 1 |
| Thiel, T | 1 |
| Spreer, J | 1 |
| Klisch, J | 1 |
| Schumacher, M | 1 |
| Roshan-Milani, S | 1 |
| Ferrigan, L | 1 |
| Khoshnood, MJ | 1 |
| Davies, CH | 1 |
| Cobb, SR | 1 |
| Hetherington, HP | 1 |
| Kim, JH | 1 |
| Pan, JW | 1 |
| Spencer, DD | 1 |
| Mueller, SG | 3 |
| D Laxer, K | 1 |
| Barakos, JA | 2 |
| Cashdollar, N | 3 |
| Flenniken, DL | 2 |
| Vermathen, P | 2 |
| Matson, GB | 2 |
| Weiner, MW | 4 |
| Briellmann, RS | 1 |
| Wellard, RM | 1 |
| Jackson, GD | 1 |
| Laxer, KD | 2 |
| Flügel, D | 1 |
| McLean, MA | 3 |
| Simister, RJ | 1 |
| Duncan, JS | 3 |
| Lopez, RC | 1 |
| Schuff, N | 1 |
| Meyerhoff, DJ | 1 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Hiremath, GK | 1 |
| Najm, IM | 1 |
| TOWER, DB | 2 |
| McEACHERN, D | 2 |
| CONE, WV | 1 |
| Paggi, A | 1 |
| Quattrini, A | 1 |
| Ortenzi, A | 1 |
| Cianci, F | 1 |
| Silvestri, R | 1 |
| Mancini, S | 1 |
| Breiter, SN | 1 |
| Arroyo, S | 1 |
| Mathews, VP | 1 |
| Lesser, RP | 1 |
| Bryan, RN | 1 |
| Barker, PB | 1 |
| Richard, O | 1 |
| Hevor, T | 1 |
| Gadian, DG | 1 |
| Kuzniecky, R | 1 |
| Hetherington, H | 1 |
| Pan, J | 1 |
| Hugg, J | 1 |
| Palmer, C | 1 |
| Gilliam, F | 1 |
| Faught, E | 1 |
| Morawetz, R | 1 |
| Holopainen, IE | 1 |
| Valtonen, ME | 1 |
| Komu, ME | 1 |
| Sonninen, PH | 1 |
| Manner, TE | 1 |
| Lundbom, NM | 1 |
| Sillanpää, ML | 1 |
| Woermann, FG | 2 |
| Barker, GJ | 2 |
| Bartlett, PA | 1 |
| Jope, RS | 1 |
| Gu, X | 1 |
| Laird, HE | 1 |
| Hadjiconstantinou, M | 1 |
| Neff, NH | 1 |
| Olney, JW | 1 |
| Collins, RC | 1 |
| Sloviter, RS | 1 |
| McGeer, PL | 1 |
| McGeer, EG | 1 |
| Sytiniskiĭ, IA | 1 |
7 reviews available for choline and Epilepsy
| Article | Year |
|---|---|
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; | 2017 |
Neuroprotective actions of perinatal choline nutrition.
Topics: Animals; Brain; Choline; DNA; Epilepsy; Gene Expression Regulation; Hippocampus; Histones; Humans; M | 2013 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
Magnetic resonance spectroscopy in animal models of epilepsy.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Choline; Creatine; Disease Models, Animal; Epilepsy; | 2007 |
Neurotransmitter synthetic enzymes.
Topics: Acetylcholine; Acetyltransferases; Adenylyl Cyclases; Aging; Aminobutyrates; Animals; Brain; Brain C | 1973 |
[Clinical use of gamma-aminobutyric acid derivatives in experimental and clinical psychiatry and neurology (review of the literature)].
Topics: Aminobutyrates; Animals; Choline; Epilepsy; Humans; Hydroxybutyrates; Hypertension; Hypoxia; Mental | 1971 |
3 trials available for choline and Epilepsy
| Article | Year |
|---|---|
Magnetisation transfer ratio of choline is reduced following epileptic seizures.
Topics: Adult; Biomarkers; Brain; Choline; Epilepsy; Female; Humans; Magnetic Resonance Spectroscopy; Magnet | 2006 |
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Dipeptides; Epilepsy | 2001 |
28 other studies available for choline and Epilepsy
| Article | Year |
|---|---|
Neurochemistry evaluated by MR spectroscopy in a patient with SPTAN1-related developmental and epileptic encephalopathy.
Topics: Choline; Epilepsy; Epilepsy, Generalized; Female; Glutamates; Glutamine; Humans; Infant; Magnetic Re | 2022 |
Altered metabolomic-genomic signature: A potential noninvasive biomarker of epilepsy.
Topics: Adolescent; Biomarkers; Brain; Child; Child, Preschool; Choline; Creatine; Epilepsy; Female; Genetic | 2017 |
LC-MS/MS imaging with thermal film-based laser microdissection.
Topics: Acetylcholine; Animals; Choline; Chromatography, Liquid; Epilepsy; Female; gamma-Aminobutyric Acid; | 2018 |
[Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice].
Topics: Animals; Anticonvulsants; Choline; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2013 |
Proton magnetic resonance spectroscopy in focal cortical dysplasia at 3T.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Child, Preschool; Choline; Creatine; Drug Resistant E | 2015 |
Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients.
Topics: Adolescent; Adult; Arachnoid Cysts; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Creatine; E | 2008 |
Grid-free interactive and automated data processing for MR chemical shift imaging data.
Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Elect | 2010 |
[Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy].
Topics: Aspartic Acid; Child; Child, Preschool; Choline; Epilepsy; Female; Humans; Magnetic Resonance Imagin | 2010 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorode | 2012 |
Acetylcholine precursor choline evokes NMDA-dependent epileptoid activity in rat hippocampal CA1 area.
Topics: Aconitine; Action Potentials; Animals; CA1 Region, Hippocampal; Choline; Dizocilpine Maleate; Epilep | 2011 |
Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.
Topics: Anticonvulsants; Aspartic Acid; Brain Chemistry; Choline; Combined Modality Therapy; Creatine; DNA M | 2012 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy | 2002 |
Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Analysis of Variance; Animals; Bicu | 2003 |
1H and 31P spectroscopic imaging of epilepsy: spectroscopic and histologic correlations.
Topics: Adult; Amygdala; Aspartic Acid; Brain; Choline; Creatine; Epilepsy; Epilepsy, Temporal Lobe; Female; | 2004 |
Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Electroencephalography; Epilepsi | 2004 |
Metabolic characteristics of cortical malformations causing epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Epilepsy; Humans; Image Proces | 2005 |
Spectroscopic evidence of hippocampal abnormalities in neocortical epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Epilepsy; Female; Functional Laterality; Hippoc | 2006 |
Acetylcholine and neuronal activity; acetylcholine and cholines terase activity in the cerebrospinal fluids of patients with epilepsy.
Topics: Acetylcholine; Choline; Epilepsy; Humans | 1949 |
Acetylcholine and neuronal activity in epilepsy.
Topics: Acetylcholine; Choline; Epilepsy | 1948 |
[Dementia syndromes and epilepsy].
Topics: Adult; Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Epilepsy; Female; Humans; | 1984 |
Proton MR spectroscopy in patients with seizure disorders.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Cerebral Cortex; Child; Child, Preschool; Choline; Creatine | 1994 |
Methionine sulfoximine increases acetylcholine level in the rat brain: no relation with epileptogenesis.
Topics: Acetylcholine; Animals; Atropine; Brain; Choline; Epilepsy; Male; Methionine Sulfoximine; Physostigm | 1995 |
N-acetylaspartate and epilepsy.
Topics: Adult; Aspartic Acid; Brain Damage, Chronic; Brain Mapping; Child; Choline; Creatine; Dominance, Cer | 1995 |
Proton spectroscopic imaging at 4.1 tesla in patients with malformations of cortical development and epilepsy.
Topics: Acetylation; Adolescent; Adult; Brain; Brain Neoplasms; Cerebral Cortex; Choline; Choristoma; Creati | 1997 |
Proton spectroscopy in children with epilepsy and febrile convulsions.
Topics: Aspartic Acid; Child; Child, Preschool; Choline; Electroencephalography; Epilepsy; Hippocampus; Huma | 1998 |
Seizures increase acetylcholine and choline concentrations in rat brain regions.
Topics: Acetylcholine; Animals; Brain; Choline; Epilepsy; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rat | 1991 |
Abnormalities in the central cholinergic transmitter system of the genetically epilepsy-prone rat.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain Chemistry; Choline; Choline O-Acetyltransferase; | 1986 |
Excitotoxic mechanisms of epileptic brain damage.
Topics: Administration, Topical; Amygdala; Animals; Axons; Biomechanical Phenomena; Brain; Choline; Cholines | 1986 |