choline has been researched along with Disease Models, Animal in 441 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver." | 8.31 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 8.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer's disease (AD)." | 8.31 | Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation. ( Alldred, MJ; Ginsberg, SD; Heguy, A; Pidikiti, H; Roussos, P, 2023) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 8.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| " The present work aimed to investigate the potential of a nanohydrogel, formed by a micellar choline-calix[4]arene amphiphile (CALIX) and CUR, in the treatment of skin diseases through an imiquimod (IMQ)-induced psoriasis model." | 7.96 | Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model. ( Ardizzone, A; Casili, G; Consoli, GML; Cuzzocrea, S; Esposito, E; Filippone, A; Granata, G; Lanza, M; Paterniti, I, 2020) |
| "Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD)." | 7.91 | Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ginsberg, SD; Kelley, CM; Mufson, EJ; Strupp, BJ, 2019) |
| "C57BL/6-GFP transgenic mice were fed with a choline-deficient diet in order to establish a fatty liver model." | 7.85 | Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. ( Aoki, H; Hasegawa, K; Hoffman, RM; Kunisada, T; Matsumoto, T; Moriwaki, H; Nakamura, M; Saji, S; Shimizu, M; Suetsugu, A, 2017) |
| "The Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD) exhibits cognitive impairment and degeneration of basal forebrain cholinergic neurons (BFCNs)." | 7.85 | Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, MS; Strupp, BJ; Velazquez, R, 2017) |
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 7.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration." | 7.83 | Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016) |
| " A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation." | 7.83 | Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. ( Alldred, MJ; Ash, JA; Caudill, MA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, M; Strupp, BJ; Velazquez, R, 2016) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 7.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "We previously reported a model of non-alcoholic fatty liver disease (NAFLD) using spontaneously hypertensive rats (SHRs), fed a choline-deficient (CD) diet for 5 weeks, that hepatic steatosis but not fibrosis is developed through oxidative stress." | 7.83 | Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease. ( Arihiro, K; Ikuta, T; Kanno, K; Kishikawa, N; Sugiyama, A; Tazuma, S; Yamamoto, H, 2016) |
| "Histamine, acting centrally as a neurotransmitter, evokes a reversal of hemorrhagic hypotension in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides." | 7.81 | Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. ( Altinbas, B; Jochem, J; Savci, V; Yalcin, M; Yilmaz, MS, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 7.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 7.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 7.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| ") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain." | 7.77 | The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011) |
| "To study role of endoplasmic reticulum stress in the development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats." | 7.76 | [Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. ( Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH, 2010) |
| "Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers." | 7.74 | Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. ( Berger-Sweeney, JE; Nag, N, 2007) |
| " Here, the anti-inflammatory activity of choline was investigated in a mouse model of allergic airway inflammation." | 7.74 | Effect of choline chloride in allergen-induced mouse model of airway inflammation. ( Arora, N; Gaur, SN; Mehta, AK; Singh, BP, 2007) |
| "Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (intravenous administration) for stroke treatment in Europe and Japan, while USA phase III stroke clinical trials (oral administration) were disappointing." | 7.73 | CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. ( Adibhatla, RM; Hatcher, JF; Tureyen, K, 2005) |
| "Non-alcoholic fatty liver disease (NAFLD) embraces several forms of liver disorders involving fat disposition in hepatocytes ranging from simple steatosis to the severe stage, namely, non-alcoholic steatohepatitis (NASH)." | 6.82 | A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet. ( Ahmeda, AF; Al Zarzour, RH; Alsalahi, A; Alshawsh, MA; Alshehade, SA; Mahmoud, AM; Saghir, SAM, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver diseases characterized by steatosis, inflammation, and fibrosis." | 5.72 | Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. ( Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N, 2022) |
| "Auraptene (AUR) is a new FXR agonist with excellent safety and extensive pharmacological activities, while the lactone of AUR is vulnerable to esterolysis." | 5.72 | SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice. ( Bian, D; Gan, J; Liu, R; Wang, C; Wen, F; Wu, X, 2022) |
| "Phosphorylcholine (PC) is an important pro-inflammatory damage-associated molecular pattern." | 5.62 | Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases. ( Bergman, A; Dahlbom, I; de Jong, RCM; de Vries, MR; Ewing, MM; Frostegård, J; Jukema, JW; Karabina, SAP; Karper, JC; Kuiper, J; MacArthur, MR; Mitchell, JR; Ninio, E; Nordzell, M; Peters, EAB; Pettersson, K; Quax, PHA; Sexton, D, 2021) |
| "PTHrP may aggravate MCD-induced NAFLD in mice by promoting the deposition of lipid droplets in the hepatocytes." | 5.62 | [Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice]. ( Bai, L; Diao, N; Qin, B, 2021) |
| "The pathogenesis of nonalcoholic fatty liver disease (NAFLD) has not be fully elucidated, and the lack of therapeutic strategies for NAFLD is an urgent health problem." | 5.56 | Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease. ( Ge, K; Jia, C; Lu, J; Zhu, H, 2020) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Choline treatment partly restored the DMRs in SHRs, which were related to 131 genes." | 5.51 | Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats. ( He, X; Liu, J; Liu, L; Wang, S; Yang, S; Yu, X; Zang, W; Zhao, M, 2019) |
| "Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences." | 5.46 | Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. ( Blusztajn, JK; Huleatt, OM; Liu, YB; Mellott, TJ; Pender, SM; Shade, BN; Slack, BE, 2017) |
| "Nonalcoholic fatty liver disease (NAFLD) refers to hepatic pathologies, including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, that may progress to hepatocellular carcinoma." | 5.43 | Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet. ( Cho, HJ; Cho, SJ; Chong, S; Chung, SJ; Kang, IM; Kim, DD; Kim, SB; Lee, JI; Yoon, IS, 2016) |
| "Choline is a fundamental nutrient for brain development and high choline intake during prenatal and/or early postnatal periods is neuroprotective." | 5.42 | High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism. ( Blusztajn, JK; Krykbaeva, M; Langley, EA; Mellott, TJ, 2015) |
| "Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5' untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation." | 5.42 | Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. ( Djazayeri, S; Liu, YY; Norman, KM; Roch, M; Scremin, OU, 2015) |
| "Quercetin (50 mg/kg) was given by oral route daily." | 5.38 | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. ( González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D, 2012) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 5.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "Despite choline deficiency, the level of choline and acetylcholine synthesizing enzyme choline acetyltransfease (ChAT) significantly increased in the brain." | 5.37 | Interaction between total body gamma-irradiation and choline deficiency triggers immediate modulation of choline and choline-containing moieties. ( Batra, V; Devasagayam, TP; Kislay, B, 2011) |
| "Choline uptake was expressed as mean and maximum standardized uptake value (SUV and SUVmax, respectively) and as the percent of injected dose (%ID) after tumour delineation on fused PET-MR images." | 5.36 | Rodent rhabdomyosarcoma: comparison between total choline concentration at H-MRS and [18F]-fluoromethylcholine uptake at PET using accurate methods for collecting data. ( Abarca-Quinones, J; Bol, A; Duprez, T; Galant, C; Gregoire, V; Labar, D; Peeters, F; Robert, A; Rommel, D, 2010) |
| "Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks." | 5.36 | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010) |
| "All CDD rats developed liver cirrhosis." | 5.35 | Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet. ( Anan, A; Irie, M; Iwata, K; Sakisaka, S; Shakado, S; Sohda, T; Takeyama, Y, 2008) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 5.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| " The results indicate that the TS16 condition in mice significantly modified the cholinergic function in brain, and to a lesser degree in spinal cord, suggesting that the higher gene dosage inherent to the trisomic condition affects cholinergic neurons in different regions of the central nervous system in a differential fashion." | 5.29 | Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). ( Caviedes, P; Caviedes, R; Epstein, CJ; Fiedler, JL; Rapoport, SI, 1994) |
| "Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology." | 5.28 | Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. ( Capacio, BR; Koviak, TA; Shih, TM, 1991) |
| "Pretreatment with idebenone (10 mg/kg, i." | 5.28 | Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1989) |
| " In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver." | 4.31 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023) |
| "The data reveals potential of saroglitazar for chemoprevention of hepatocellular carcinoma in patients with NAFLD/NASH." | 4.31 | Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet. ( Bhoi, B; Giri, SR; Ingale, K; Jain, MR; Kadam, S; Nyska, A; Patel, H; Ranvir, R; Rath, A; Rathod, R; Sharma, A; Trivedi, C, 2023) |
| "Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice." | 4.31 | Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023) |
| "Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer's disease (AD)." | 4.31 | Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation. ( Alldred, MJ; Ginsberg, SD; Heguy, A; Pidikiti, H; Roussos, P, 2023) |
| " Previously, we reported a dietary mouse NASH model with a choline-deficient, methionine-lowered, L-amino-acid-defined, high-fat diet containing shortening without trans fatty acids (CDAA-HF-T[-]), which rapidly induces fibrosis and proliferative lesions in the liver." | 4.31 | Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes. ( Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M, 2023) |
| "2% adenine diet for 14 weeks developed CKD with elevated plasma levels of TMAO, provision of a non-lethal inhibitor of gut microbial trimethylamine (TMA) production, iodomethylcholine (IMC), significantly reduced multiple markers of renal injury (plasma creatinine, cystatin C, FGF23, and TMAO), reduced histopathologic evidence of fibrosis, and markedly attenuated development of microalbuminuria." | 4.02 | Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. ( Charugundla, S; Guo, F; Hazen, SL; Jia, X; Kaczor-Urbanowicz, KE; Lusis, AJ; Magyar, C; Miikeda, A; Nicholas, SB; Pellegrini, M; Shih, DM; Wang, Z; Zhang, W; Zhou, Z; Zuckerman, J, 2021) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 4.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| "Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet, produces trimethylamine (TMA) and the atherothrombosis- and fibrosis-promoting metabolite TMA-N-oxide (TMAO)." | 3.96 | Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease. ( Buffa, JA; DiDonato, JA; Gupta, N; Hazen, SL; Ho, KJ; Li, L; Roberts, AB; Sangwan, N; Skye, SM; Tang, WHW; Varga, J, 2020) |
| "Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine." | 3.96 | Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. ( Goodchild, TT; Gupta, N; Hazen, SL; Lefer, DJ; Li, Z; Organ, CL; Polhemus, DJ; Sharp, TE; Tang, WHW, 2020) |
| " The methylation of phosphatidylethanolamine to form choline has been extensively studied in the context of fatty liver disease." | 3.96 | Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. ( da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE, 2020) |
| " The present work aimed to investigate the potential of a nanohydrogel, formed by a micellar choline-calix[4]arene amphiphile (CALIX) and CUR, in the treatment of skin diseases through an imiquimod (IMQ)-induced psoriasis model." | 3.96 | Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model. ( Ardizzone, A; Casili, G; Consoli, GML; Cuzzocrea, S; Esposito, E; Filippone, A; Granata, G; Lanza, M; Paterniti, I, 2020) |
| " To induce liver steatosis and inflammation, we fed C57/black female mice (8 weeks old) a methionine-choline deficient diet (MCD diet) for 6 weeks." | 3.96 | Automated thermal imaging for the detection of fatty liver disease. ( Balint-Lahat, N; Ben-Ari, Z; Brzezinski, RY; Finchelman, JM; Grossman, E; Hoffer, O; Leor, J; Levin-Kotler, L; Lewis, N; Naftali-Shani, N; Ovadia-Blechman, Z; Rabin, N; Safran, M; Sternfeld, A; Tepper-Shaihov, O; Unis, R; Zimmer, Y, 2020) |
| "Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD)." | 3.91 | Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ginsberg, SD; Kelley, CM; Mufson, EJ; Strupp, BJ, 2019) |
| " In the present study, we used our malignant lymphoma metastatic mouse model to compare the effect of a choline-deficient-diet (CDD) and the control diet (CD) on fibroblasts in CTCs." | 3.91 | Choline-deficient-diet Decreases Fibroblasts in the Circulating Tumor Cell (CTC) Microenvironment. ( Hoffman, RM; Kunisada, T; Matsuura, K; Nakamura, M; Satake, T; Shimizu, M; Suetsugu, A, 2019) |
| " As TPN-associated complications are partially related to choline deficiency, we aimed to address whether choline supplementation could attenuate OOLE-induced enterocyte apoptosis." | 3.88 | Supplementary choline attenuates olive oil lipid emulsion-induced enterocyte apoptosis through suppression of CELF1/AIF pathway. ( Cai, W; Gong, ZZ; Wen, J; Xiao, YT; Yan, JK; Zhang, T; Zhu, J, 2018) |
| " Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo." | 3.88 | Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. ( Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y, 2018) |
| "C57BL/6-GFP transgenic mice were fed with a choline-deficient diet in order to establish a fatty liver model." | 3.85 | Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. ( Aoki, H; Hasegawa, K; Hoffman, RM; Kunisada, T; Matsumoto, T; Moriwaki, H; Nakamura, M; Saji, S; Shimizu, M; Suetsugu, A, 2017) |
| "The Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD) exhibits cognitive impairment and degeneration of basal forebrain cholinergic neurons (BFCNs)." | 3.85 | Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, MS; Strupp, BJ; Velazquez, R, 2017) |
| "Pancreatitis was induced in BALB/c and FVB/N mice by administration of cerulein or feeding a choline-deficient, ethionine-supplemented (CDE) diet." | 3.85 | Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis. ( Iyer, S; Kwan, R; Liao, J; Liu, L; Moons, D; Omary, MB; Park, MJ, 2017) |
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 3.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration." | 3.83 | Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016) |
| " A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation." | 3.83 | Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. ( Alldred, MJ; Ash, JA; Caudill, MA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, M; Strupp, BJ; Velazquez, R, 2016) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 3.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "We previously reported a model of non-alcoholic fatty liver disease (NAFLD) using spontaneously hypertensive rats (SHRs), fed a choline-deficient (CD) diet for 5 weeks, that hepatic steatosis but not fibrosis is developed through oxidative stress." | 3.83 | Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease. ( Arihiro, K; Ikuta, T; Kanno, K; Kishikawa, N; Sugiyama, A; Tazuma, S; Yamamoto, H, 2016) |
| "The choline-derived metabolite trimethylamine N-oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk." | 3.83 | Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. ( Hazen, SL; Lusis, AJ; Meng, Y; Qi, H; Seldin, MM; Shih, DM; Wang, Z; Zhu, W, 2016) |
| ") choline treatment on serum matrix metalloproteinases (MMP), MMP tissue inhibitors (TIMP) and immunoglobulins (Igs), and to determine if there were relations between serum MMPs/TIMPs and C-reactive protein (CRP) (as a marker of the acute phase response), immunoglobulin G and M (IgG and IgM) (as a maker of the Ig responses) and markers of organ damage such as muscular damage (creatine phosphokinase, [CPK]), liver damage (alanine aminotransferase [ALT]) and renal dysfunction (blood urea nitrogen [BUN] and creatinine, [Cr]) in dogs with endotoxemia." | 3.83 | Effects of choline treatment in concentrations of serum matrix metalloproteinases (MMPs), MMP tissue inhibitors (TIMPs) and immunoglobulins in an experimental model of canine sepsis. ( Cansev, M; Ceron, JJ; Eralp-Inan, O; Kahraman, MM; Kocaturk, M; Ozyigit, MO; Tvarijonaviciute, A; Yilmaz, Z, 2016) |
| "Histamine, acting centrally as a neurotransmitter, evokes a reversal of hemorrhagic hypotension in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides." | 3.81 | Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. ( Altinbas, B; Jochem, J; Savci, V; Yalcin, M; Yilmaz, MS, 2015) |
| "Weanling male Wistar rats fed a choline-deficient diet develop acute kidney injury." | 3.81 | Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. ( Denninghoff, VC; Díaz, ML; Monserrat, AJ; Ossani, GP; Uceda, AM; Uicich, R, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 3.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "Down syndrome (DS), trisomy 21, is a multifaceted condition marked by intellectual disability and early presentation of Alzheimer's disease (AD) neuropathological lesions including degeneration of the basal forebrain cholinergic neuron (BFCN) system." | 3.80 | Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014) |
| "Methionine-choline deficient (MCD) diet duration necessary for development of non-alcoholic fatty liver disease (NAFLD) and the dynamic of lipid profile and fatty acids are not completely established." | 3.80 | Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease. ( Aleksić, V; Duričić, I; Ješić-Vukićević, R; Jorgačević, B; Mladenović, DR; Radosavljević, TS; Šobajić, SS; Stanković, MN; Timić, J; Vučević, DB, 2014) |
| "Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration." | 3.80 | Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014) |
| "The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice." | 3.79 | [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. ( Pomytkin, IA; Rychikhin, VM; Sariev, AK, 2013) |
| "To dissociate the effects of dietary folate and choline deficiency on Shmt1-related NTD sensitivity, we determined NTD incidence in embryos from Shmt1-null dams fed diets deficient in either folate or choline." | 3.78 | Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. ( Abarinov, EV; Beaudin, AE; Caudill, M; Malysheva, O; Perry, CA; Stover, PJ, 2012) |
| "Reduced folate and choline status resulted in severe fetal growth restriction (FGR) and impaired fertility in litters harvested from Mthfd1(gt/+) dams, but embryonic Mthfd1(gt/+) genotype did not affect fetal growth." | 3.78 | Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. ( Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ, 2012) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 3.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "Macrovesicular and microvescular steatosis were induced in rats using methylcholine deficiency and choline deficiency diets." | 3.78 | Quantification of macrovesicular and microvesicular hepatic steatosis in rats using 3.0-T ¹H-magnetic resonance spectroscopy. ( Chang, YC; Chao, PH; Chen, CL; Cheng, YF; Chiu, TM; Lai, CY; Ou, HY; Wei, YC; Yu, CY; Yu, PC, 2012) |
| "We examined whether genetic disruption of the Shmt1 gene in mice induces NTDs in response to maternal folate and choline deficiency and whether a corresponding disruption in de novo thymidylate biosynthesis underlies NTD pathogenesis." | 3.77 | Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. ( Abarinov, EV; Allen, RH; Beaudin, AE; Chu, S; Noden, DM; Perry, CA; Stabler, SP; Stover, PJ, 2011) |
| "We studied the long-term effects of a postnatal choline supplementation (from birth till weaning) in the truncated MeCP2-308 mouse model of Rett syndrome." | 3.77 | Cholinergic hypofunction in MeCP2-308 mice: beneficial neurobehavioural effects of neonatal choline supplementation. ( De Filippis, B; Fuso, A; Laviola, G; Ricceri, L, 2011) |
| ") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain." | 3.77 | The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011) |
| "Compared to the control group, pretreatment with choline significantly decreased ischaemia-induced arrhythmias, reduced the total number of ventricular premature beats, the duration of ventricular tachycardia episodes and markedly reduced I/R-induced infarct size." | 3.76 | Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression. ( Chen, X; Du, Z; Liu, Y; Lu, Y; Pan, Z; Su, Y; Yang, B; Yang, L; Zhang, Y; Zhao, J, 2010) |
| "To study role of endoplasmic reticulum stress in the development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats." | 3.76 | [Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. ( Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH, 2010) |
| "It is well known that choline has protective effects on ischemic arrhythmias." | 3.74 | Choline produces antiarrhythmic actions in animal models by cardiac M3 receptors: improvement of intracellular Ca2+ handling as a common mechanism. ( Du, ZM; Gao, Y; Li, DL; Liu, Y; Lu, YJ; Sun, HL; Wang, LY; Wang, YP; Yang, BF, 2008) |
| "To clarify the causal relationship between insulin resistance and the development of NASH, steatohepatitis was induced in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) and nondiabetic control Long-Evans Tokushima Otsuka (LETO) rats by feeding them a methionine and choline-deficient (MCD) diet." | 3.74 | Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. ( Akahori, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa, N; Misu, H; Nakanuma, Y; Ota, T; Sakurai, M; Takamura, T; Uno, M; Zen, Y, 2007) |
| "Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h." | 3.74 | Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. ( Cottagnoud, M; Cottagnoud, P; Schaffner, T; Stucki, A; Winkelmann, V, 2007) |
| "Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers." | 3.74 | Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. ( Berger-Sweeney, JE; Nag, N, 2007) |
| " Here, the anti-inflammatory activity of choline was investigated in a mouse model of allergic airway inflammation." | 3.74 | Effect of choline chloride in allergen-induced mouse model of airway inflammation. ( Arora, N; Gaur, SN; Mehta, AK; Singh, BP, 2007) |
| "Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (intravenous administration) for stroke treatment in Europe and Japan, while USA phase III stroke clinical trials (oral administration) were disappointing." | 3.73 | CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. ( Adibhatla, RM; Hatcher, JF; Tureyen, K, 2005) |
| "Mdr2 (+/-) and Mdr2 (+/+) mice were treated with an MCD or control diet for up to 30 days, and the severity of steatohepatitis, PEMT activity and hepatic S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH) levels were measured." | 3.73 | Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. ( Green, RM; Igolnikov, AC, 2006) |
| " Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failure (CHF), methylcholine (Meth), and control." | 3.73 | Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling. ( Everett, TH; Foreman, S; Guerra, JM; Olgin, JE; Verheule, S; Wilson, EE, 2006) |
| "Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls." | 3.73 | In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006) |
| " Since motion sickness can be cured by scopolamine, cholinergic neuron system may also be involved in vestibulo-autonomic responses." | 3.70 | Cholinergic influence on vestibular stimulation-induced locus coeruleus inhibition in rats. ( Kubo, T; Nakamura, S; Nishiike, S; Takeda, N; Uno, A; Yamatodani, A, 2000) |
| "A new experimental model has been found whereby acute hemorrhagic pancreatic necrosis with fat necrosis is induced in 100% of young female mice fed a choline-deficient diet supplemented with 0." | 3.65 | Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum. ( Lombardi, B; Rao, KN; Tuma, J, 1976) |
| "Non-alcoholic fatty liver disease (NAFLD) embraces several forms of liver disorders involving fat disposition in hepatocytes ranging from simple steatosis to the severe stage, namely, non-alcoholic steatohepatitis (NASH)." | 2.82 | A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet. ( Ahmeda, AF; Al Zarzour, RH; Alsalahi, A; Alshawsh, MA; Alshehade, SA; Mahmoud, AM; Saghir, SAM, 2022) |
| "Phenylacetylglutamine, for example, was recently shown to promote adverse cardiovascular phenotypes in the host via interaction with multiple ARs (adrenergic receptors)-a class of key receptors that regulate cardiovascular homeostasis." | 2.66 | Gut Microbiota and Cardiovascular Disease. ( Hazen, SL; Weeks, TL; Witkowski, M, 2020) |
| "Down syndrome affects more than 5 million people globally." | 2.50 | Prenatal treatment of Down syndrome: a reality? ( Bianchi, DW; Delabar, JM; Guedj, F, 2014) |
| "Betaine is a significant determinant of plasma tHcy, particularly in case of folate deficiency, methionine load, or alcohol consumption." | 2.49 | The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. ( Obeid, R, 2013) |
| "Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998." | 2.45 | Choline: an essential nutrient for public health. ( da Costa, KA; Zeisel, SH, 2009) |
| "Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes." | 2.39 | Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996) |
| " Excitoxins when infused directly into the Nbm destroy non-specifically cell bodies but spare axons passing the injection site, whereas the specificity of AF64A to destroy cholinergic neurons depends on both the dosage applied and the site of injection." | 2.39 | Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. ( Bigl, V; Rossner, S; Schliebs, R, 1996) |
| "Dietary choline deficiency altered hippocampal networks associated with microtubule function and postsynaptic membrane regulation." | 1.91 | Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks. ( Bartholomew, SK; Bilal, A; Blackwood, EA; Dave, N; Decker, A; Glembotski, C; Judd, JM; Karr, T; McDonough, I; Sandler, J; Sarette, P; Tallino, S; Velazquez, R; Villarreal Espinosa, O; Winslow, W; Winstone, JK, 2023) |
| "Chrysin (CH) has been reported to have anti-inflammatory effects but shows lower bioavailability." | 1.91 | Chrysin and its nanoliposome ameliorated non-alcoholic steatohepatitis via inhibiting TLR4 signalling pathway. ( Gong, X; Hu, J; Jiang, N; Kuang, G; Liu, H; Liu, J; Wan, J; Wu, S; Yin, X, 2023) |
| "Choline is an essential nutrient that must be obtained from the diet and its deficiency promotes fatty liver disease in a process dependent on ASM activity." | 1.91 | Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency. ( Casas, J; Gaudioso, Á; Ledesma, MD; Moreno-Huguet, P; Schuchman, EH, 2023) |
| "However, the effect of ACT001 on nonalcoholic steatohepatitis (NASH) is unknown." | 1.91 | iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice. ( Chen, Z; Chu, W; Li, P; Liu, Y; Mi, Y; Niu, B; Wu, X; Zhou, H; Zhou, Y, 2023) |
| "plantarum against nonalcoholic steatohepatitis (NASH) and its underlying mechanisms remain unelucidated." | 1.91 | Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production. ( Gee, HY; Kim, DY; Park, JY, 2023) |
| "Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver diseases characterized by steatosis, inflammation, and fibrosis." | 1.72 | Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. ( Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N, 2022) |
| "Auraptene (AUR) is a new FXR agonist with excellent safety and extensive pharmacological activities, while the lactone of AUR is vulnerable to esterolysis." | 1.72 | SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice. ( Bian, D; Gan, J; Liu, R; Wang, C; Wen, F; Wu, X, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD) is currently a growing epidemic disease that can lead to cirrhosis and hepatic cancer when it evolves into non-alcoholic steatohepatitis (NASH), a gap not well understood." | 1.72 | Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model. ( Alastrué-Vera, V; Arnal, C; Barranquero, C; García-Gil, A; Gascón, S; Gonzalo-Romeo, G; Güemes, A; Gutiérrez-Blázquez, D; Herrera-Marcos, LV; Herrero-Continente, T; Lou-Bonafonte, JM; Macías-Herranz, M; Martínez-Beamonte, R; Osada, J; Puente-Lanzarote, JJ; Rodríguez-Yoldi, MJ; Surra, JC, 2022) |
| "Individuals with fetal alcohol spectrum disorders (FASD) incur enduring brain damage and neurodevelopmental impairments from prenatal alcohol exposure (PAE)." | 1.72 | The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent. ( Carugati, M; Cudd, TA; Goodlett, CR; Washburn, SE, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD), one of the most common forms of chronic liver disease, is characterized by the excessive accumulation of lipid species in hepatocytes." | 1.72 | Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice. ( Avigan, MI; Beland, FA; da Costa, GG; de Conti, A; Nagumalli, SK; Pogribny, IP; Rusyn, I; Tryndyak, VP; Willett, RA, 2022) |
| "Severe acute pancreatitis can easily lead to systemic inflammatory response syndrome and death." | 1.72 | USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-κB Signaling in Macrophages. ( Chen, J; Hu, C; Huang, L; Liang, G; Liu, X; Luo, W; Mutsinze, RN; Wang, X; Wang, Y; Zhang, Y; Zuo, W, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD) ranks first among liver diseases in Western countries." | 1.72 | Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice. ( Farazi, PA; Fisher, KW; Hymel, E; Vlock, E, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD), represents an unmet medical need that can progress to non-alcoholic steatohepatitis (NASH), which, without intervention, can result in the development of cirrhosis and hepatocellular carcinoma (HCC)." | 1.72 | IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models. ( Brightbill, HD; Ding, N; Flanagan, S; Ghilardi, N; Heredia, JE; Jones, C; Leong, L; Martinez, AP; Martzall, A; Nunez, V; Scherl, A; Sorenson, C, 2022) |
| "Disease progression was investigated at 4 time points, from 9 to 18 months of age, and in 4 regions: cortex, hippocampus, striatum, and thalamus." | 1.72 | Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. ( López-Gil, X; Muñoz-Moreno, E; Simões, RV; Soria, G; Tudela, R, 2022) |
| "Rosmarinic acid (RA) has positive effects on the liver injuries; nevertheless, its mechanisms are not completely studied." | 1.72 | SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH). ( Bassirian, M; Changizi, Z; Komeili-Movahhed, T; Moslehi, A, 2022) |
| "Choline is an essential nutrient under evaluation as a cognitive enhancing treatment for fetal alcohol spectrum disorders (FASD) in clinical trials." | 1.62 | Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. ( Christie, BR; Fontaine, CJ; Grafe, EL; Thomas, JD, 2021) |
| "Phosphorylcholine (PC) is an important pro-inflammatory damage-associated molecular pattern." | 1.62 | Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases. ( Bergman, A; Dahlbom, I; de Jong, RCM; de Vries, MR; Ewing, MM; Frostegård, J; Jukema, JW; Karabina, SAP; Karper, JC; Kuiper, J; MacArthur, MR; Mitchell, JR; Ninio, E; Nordzell, M; Peters, EAB; Pettersson, K; Quax, PHA; Sexton, D, 2021) |
| "Cantharidin (CTD) is a promising anticancer drug; however, its dosage is limited by hepatotoxicity." | 1.62 | Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics. ( Chen, Y; Huang, X; Li, W; Lin, C; Liu, J; Sa, Z; Tang, W; Wang, L; Xu, M; Yang, C, 2021) |
| "PTHrP may aggravate MCD-induced NAFLD in mice by promoting the deposition of lipid droplets in the hepatocytes." | 1.62 | [Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice]. ( Bai, L; Diao, N; Qin, B, 2021) |
| "The pathogenesis of nonalcoholic fatty liver disease (NAFLD) has not be fully elucidated, and the lack of therapeutic strategies for NAFLD is an urgent health problem." | 1.56 | Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease. ( Ge, K; Jia, C; Lu, J; Zhu, H, 2020) |
| "A proportion of NAFLD patients develop hepatic inflammation, known as Non-Alcoholic Steatohepatitis (NASH), which can end up in cirrhosis, or Hepatocellular Carcinoma (HCC)." | 1.56 | Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet. ( Angulo, S; Carril, E; Godzien, J; Lanzón, B; Rupérez, FJ; Valdecantos, MP; Valverde, ÁM, 2020) |
| "Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic seatohepatitis (NASH) is one of the major health problems world wide, because of increased abdominal obesity." | 1.56 | Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH). ( Hiraoka, Y; Kume, N; Shimizu, R; Torii, H; Yasuda, D, 2020) |
| "Nonalcoholic fatty liver disease (NAFLD) represents a hepatic manifestation of metabolic syndrome." | 1.56 | Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD. ( Jadžić, J; Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Vesković, M; Vučević, D; Vukićević, D, 2020) |
| "Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer." | 1.56 | A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet. ( Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M, 2020) |
| "The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades." | 1.56 | Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations. ( Caccamo, A; Dave, N; Ferreira, E; Huentelman, MJ; Naymik, M; Oddo, S; Piras, IS; Tran, A; Velazquez, R; Winslow, W, 2020) |
| "Lipopolysaccharide (LPS)-induced encephalopathy induces neuroinflammation." | 1.51 | Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. ( Gulej, R; Lawrence, B; McKenzie, T; Morton, KA; Saunders, D; Smith, N; Towner, RA, 2019) |
| "Choline-based BIL is a structural precursor of the phospholipid bilayer in the cell membrane." | 1.51 | Bioionic Liquid Conjugation as Universal Approach To Engineer Hemostatic Bioadhesives. ( Ellis, E; Hannah, T; Hazelton, J; Kanjilal, B; Kapetanakis, A; Krishnadoss, V; Leijten, J; Masoumi, A; Melillo, A; Noshadi, I; San Roman, J, 2019) |
| "For this purpose, we established a NAFLD model by feeding C57BL/6J mice a methionine‑choline‑deficient diet." | 1.51 | Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease. ( Chen, X; Huang, YM; Li, CP; Lü, MH; Shi, L; Wang, XM; Wang, XY, 2019) |
| "Choline treatment may represent a new therapeutic strategy for optimizing myocardial metabolism in the context of hypertrophy and heart failure." | 1.51 | Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway. ( Cui, YL; Lu, Y; Wu, Q; Xu, M; Xue, RQ; Yong, SY; Yu, XJ; Zang, WJ; Zhao, M; Zuo, XT, 2019) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in western countries, with a continuously rising incidence." | 1.51 | Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis. ( Bennek, E; Candels, LS; Elfers, C; Gassler, N; Heymann, F; Kilic, K; Mohs, A; Penders, J; Schneider, KM; Schneider, LB; Trautwein, C, 2019) |
| "Choline treatment partly restored the DMRs in SHRs, which were related to 131 genes." | 1.51 | Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats. ( He, X; Liu, J; Liu, L; Wang, S; Yang, S; Yu, X; Zang, W; Zhao, M, 2019) |
| " sanctum with a dosage of 100 mg/kg b." | 1.48 | Ethanolic extract Ocimum sanctum. Enhances cognitive ability from young adulthood to middle aged mediated by increasing choline acetyl transferase activity in rat model. ( Auriva, MB; Haryanto, A; Hening, P; Jadi, AR; Karnati, S; Kusindarta, DL; Lochnit, G; Purwaningrum, M; Wihadmadyatami, H, 2018) |
| "In a nutritional model of hepatocarcinogenesis, the protein Nrf2 is frequently mutated/activated at early steps of the tumorigenic process." | 1.48 | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. ( Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis." | 1.46 | Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. ( Alfaro, M; Chintapalli, SV; Kang, P; Shankar, K; Thakali, KM; Wankhade, UD; Zhong, Y, 2017) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and ranges from isolated steatosis to NASH." | 1.46 | Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid. ( Beretta, L; Fallon, M; Gjuka, D; Harrison, SA; Ioannou, GN; Shen, H; Song, X; Stevenson, HL; Wang, J; Yoo, SY; Yoo, W, 2017) |
| "Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences." | 1.46 | Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. ( Blusztajn, JK; Huleatt, OM; Liu, YB; Mellott, TJ; Pender, SM; Shade, BN; Slack, BE, 2017) |
| "Choline is an essential nutrient, and its deficiency is related to PN-associated organ diseases." | 1.43 | Choline Alleviates Parenteral Nutrition-Associated Duodenal Motility Disorder in Infant Rats. ( Cai, W; Guo, Y; Huang, H; Lu, T; Tang, Q; Wu, Y; Zhu, J, 2016) |
| "The (18)F-FMCH uptake in atherosclerotic plaques was further compared with macrophage infiltration and the plasma levels of cytokines and metabolic markers." | 1.43 | Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸F-fluoromethylcholine. ( Hellberg, S; Jauhiainen, M; Kiugel, M; Knuuti, J; Liljenbäck, H; Metsälä, O; Metso, J; Nuutila, P; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Viljanen, T; Ylä-Herttuala, S, 2016) |
| "Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide." | 1.43 | Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. ( Cappelletti, M; Divanovic, S; Dong, C; Giles, DA; Huppert, SS; Iwakura, Y; Moreno-Fernandez, ME; Shanmukhappa, SK; Stankiewicz, TE, 2016) |
| "Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer." | 1.43 | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. ( Egger, M; Eggert, T; ElGindi, M; Felsher, DW; Greten, TF; Han, M; Heikenwalder, M; Jin, P; Kapoor, V; Kesarwala, AH; Kleiner, DE; Luo, J; Ma, C; McVicar, DW; Medina-Echeverz, J; Stroncek, DF; Terabe, M; Thornton, AM; Weber, A; Zhang, H, 2016) |
| "Nonalcoholic fatty liver disease (NAFLD) refers to hepatic pathologies, including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, that may progress to hepatocellular carcinoma." | 1.43 | Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet. ( Cho, HJ; Cho, SJ; Chong, S; Chung, SJ; Kang, IM; Kim, DD; Kim, SB; Lee, JI; Yoon, IS, 2016) |
| "Choline is a fundamental nutrient for brain development and high choline intake during prenatal and/or early postnatal periods is neuroprotective." | 1.42 | High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism. ( Blusztajn, JK; Krykbaeva, M; Langley, EA; Mellott, TJ, 2015) |
| "Animal models of Fetal Alcohol Spectrum Disorders (FASD) afford the unique capacity to precisely control timing of alcohol exposure and alcohol exposure amounts in the developing animal." | 1.42 | An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics. ( Barnet, RC; Hunt, PS, 2015) |
| "Sprague-Dawley rats underwent complete spinal cord transection at the T-9 level, followed by implantation of bFGF/HEMA-MOETACL 5 days after transection surgery." | 1.42 | Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats. ( Chen, B; Hao, D; He, J; Huang, L; Liu, C; Wang, Y; Xie, E; Yang, H; Zhang, L; Zhang, Q; Zhang, R; Zhang, X, 2015) |
| "Brain edema was maximal on MR imaging 3 h after poisoning." | 1.42 | Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model. ( Cohen, Y; Eisenkraft, A; Kadar, T; Kassirer, M; Milk, N; Rosman, Y; Shiyovich, A; Shrot, S; Tauber, M, 2015) |
| "MCD diet resulted in steatohepatitis and increased miR-155 expression in total liver, hepatocytes and Kupffer cells." | 1.42 | MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. ( Bala, S; Catalano, D; Csak, T; Iracheta-Vellve, A; Kodys, K; Lippai, D; Szabo, G, 2015) |
| "Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5' untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation." | 1.42 | Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. ( Djazayeri, S; Liu, YY; Norman, KM; Roch, M; Scremin, OU, 2015) |
| "Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet." | 1.40 | Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. ( Guo, J; Li, J; Li, X; Liu, Y; Wang, L; Wu, T; Yang, Y; Yuan, F; Zhang, Q; Zheng, L, 2014) |
| "Depression is associated with structural and neurochemical changes in limbic structures, including the hippocampus, that control emotion and mood." | 1.39 | Phospholipase D-mTOR signaling is compromised in a rat model of depression. ( Feng, P; Huang, C, 2013) |
| "Spinocerebellar ataxia type 1 (SCA1) is a hereditary, progressive and fatal movement disorder that primarily affects the cerebellum." | 1.39 | Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1. ( Brent Clark, H; Eberly, LE; Emir, UE; Öz, G; Vollmers, ML, 2013) |
| "Myo-inositol (mIns) is a marker of glial cells proliferation and has been shown to increase in early Alzheimer's disease (AD) pathology." | 1.39 | MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. ( Cai, K; Crescenzi, R; Hariharan, H; Haris, M; Kogan, F; Nath, K; Reddy, R; Singh, A, 2013) |
| "Rats with the metabolic syndrome have ineffective inflammation-resolving mechanisms that represent plausible reasons for the exaggerated and persistent PCD." | 1.39 | Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. ( Britton, SL; Chawla, A; Feng, X; Koch, LG; Matthay, MA; Maze, M; Su, X; Terrando, N; Yan, Y, 2013) |
| "A well-validated animal model of treatment resistant depression (congenital learned helpless rats = cLH) was investigated by hippocampal in vivo ¹H MRS with and without a 1-week course of electroconvulsive shocks (ECS), an animal model of ECT, and compared to wild type (WT) animals, while saline and clomipramine injections served as additional controls." | 1.38 | Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression. ( Biedermann, S; Ende, G; Gass, P; Hoyer, C; Sartorius, A; Vollmayr, B; Weber-Fahr, W; Zheng, L, 2012) |
| "NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in Western populations." | 1.38 | Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. ( Chaba, T; Jacobs, RL; Ling, J; Vance, DE; Zhu, LF, 2012) |
| "Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis." | 1.38 | Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012) |
| "Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world." | 1.38 | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. ( Camporez, JP; Eisenbarth, SC; Elinav, E; Flavell, RA; Gordon, JI; Hao, L; Henao-Mejia, J; Hoffman, HM; Jin, C; Jurczak, MJ; Kau, AL; Mehal, WZ; Shulman, GI; Strowig, T; Thaiss, CA, 2012) |
| "Murine models of Alzheimer's disease (AD) provide means to detect and follow biomarker changes similar to those observed in humans." | 1.38 | Systematic evaluation of magnetic resonance imaging and spectroscopy techniques for imaging a transgenic model of Alzheimer's disease (AβPP/PS1). ( Alquézar, C; Antequera, D; Barrios, L; Bartolomé, F; Carro, E; Cerdán, S; Esteras, N; Martín-Requero, A, 2012) |
| "Quercetin (50 mg/kg) was given by oral route daily." | 1.38 | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. ( González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D, 2012) |
| "The mechanisms triggering nonalcoholic steatohepatitis (NASH) remain poorly defined." | 1.38 | Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. ( Hahn, YS; Landes, SG; Nguyen, V; Novobrantseva, TI; Tosello-Trampont, AC, 2012) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 1.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| " Toxic signs and survival were evaluated at key times for up to 72 h following soman exposure." | 1.37 | Diet composition exacerbates or attenuates soman toxicity in rats: implied metabolic control of nerve agent toxicity. ( Langston, JL; Myers, TM, 2011) |
| "Treatment with choline or cytidine alone led to a less marked improvement in SFI score and failed to increase axon count." | 1.37 | CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves. ( Aslan, E; Bekar, A; Kocaeli, H; Tolunay, S; Ulus, IH, 2011) |
| "Despite choline deficiency, the level of choline and acetylcholine synthesizing enzyme choline acetyltransfease (ChAT) significantly increased in the brain." | 1.37 | Interaction between total body gamma-irradiation and choline deficiency triggers immediate modulation of choline and choline-containing moieties. ( Batra, V; Devasagayam, TP; Kislay, B, 2011) |
| "The pathogenesis of nonalcoholic steatohepatitis (NASH) is still unclear." | 1.36 | Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. ( Fujita, K; Inamori, M; Iwasaki, T; Kirikoshi, H; Maeyama, S; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Terauchi, Y; Wada, K; Yoneda, M, 2010) |
| "Choline uptake was expressed as mean and maximum standardized uptake value (SUV and SUVmax, respectively) and as the percent of injected dose (%ID) after tumour delineation on fused PET-MR images." | 1.36 | Rodent rhabdomyosarcoma: comparison between total choline concentration at H-MRS and [18F]-fluoromethylcholine uptake at PET using accurate methods for collecting data. ( Abarca-Quinones, J; Bol, A; Duprez, T; Galant, C; Gregoire, V; Labar, D; Peeters, F; Robert, A; Rommel, D, 2010) |
| "Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks." | 1.36 | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. ( Kawada, N; Mu, YP; Ogawa, T, 2010) |
| "After nitroglycerin administration, the migraine rat model was established according to ethology evaluation." | 1.35 | Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo. ( Gu, T; Li, CF; Ma, XX; Ma, Z; Wang, SJ, 2008) |
| "Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion." | 1.35 | Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. ( Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH, 2008) |
| "Steatohepatitis was induced by feeding wild-type or IL-6(-/-) mice for 5 weeks with a methionine and choline-deficient (MCD) diet." | 1.35 | IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. ( Carpentier, S; Danjoux, M; Garcia, V; Levade, T; Mas, E; Ségui, B, 2009) |
| "Pre-treatment with mecamylamine (50 mug; i." | 1.35 | Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. ( Cansev, M; Hamurtekin, E; Ilcol, YO; Ulus, IH; Yilmaz, MS, 2008) |
| "All CDD rats developed liver cirrhosis." | 1.35 | Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet. ( Anan, A; Irie, M; Iwata, K; Sakisaka, S; Shakado, S; Sohda, T; Takeyama, Y, 2008) |
| "Although prostate cancer in TRAMP mice shares some metabolic features with that in humans, it differs with respect to choline phospholipid metabolism, which could impact upon the interpretation of results from biomarker or chemotherapy/chemoprevention studies." | 1.35 | Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism. ( Edwards, RE; Farmer, PB; Gant, TW; Gescher, AJ; Greaves, P; Jones, DJ; Keun, HC; Steward, WP; Teahan, O; Teichert, F; Verschoyle, RD; Wilson, ID, 2008) |
| "Prion diseases are fatal chronic neurodegenerative diseases." | 1.34 | MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. ( Anthony, DC; Blamire, AM; Broom, KA; Griffin, JL; Lowe, JP; Perry, VH; Scott, H; Sibson, NR; Styles, P, 2007) |
| "Additionally, the lipid content in pancreatic cancer was higher than that in chronic pancreatitis." | 1.34 | Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high-resolution magic angle spinning 1H nuclear magnetic resonance and principal components analysis. ( Chen, Q; Deng, H; Fang, F; He, X; Lu, J; Spraul, M; Yu, Y, 2007) |
| "Thus, effective treatment of fibrosis in inflammatory bowel disease may require early and complete blockade of NF-kappaB with particular attention to specific proinflammatory and profibrogenic genes that remain active at low levels of NF-kappaB." | 1.34 | Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. ( Chakravarti, S; Wu, F, 2007) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 1.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "In the MCD dietary model of steatohepatitis, NF-kappaB is activated early and is an important proinflammatory mediator of lesion development, but steatohepatitis occurs independently of TNF synthesis and TNFR-1 activation." | 1.33 | NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. ( Dela Peña, A; Farrell, G; Field, J; George, J; Jones, B; Leclercq, I, 2005) |
| "Nonalcoholic fatty liver (NAFL) and steatohepatitis (NASH) may accompany obesity, diabetes, parenteral nutrition, jejeuno-ileal bypass, and chronic inflammatory bowel disease." | 1.33 | Glutathione-enhancing agents protect against steatohepatitis in a dietary model. ( Chen, TS; de Villiers, WJ; Im, HJ; McClain, CJ; Oz, HS, 2006) |
| "Nonalcoholic steatohepatitis (NASH) may cause fibrosis, cirrhosis, and hepatocellular carcinoma (HCC); however, the exact mechanism of disease progression is not fully understood." | 1.33 | Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. ( Akahane, T; Asada, K; Fukui, H; Ikenaka, Y; Kaji, K; Kitade, M; Kojima, H; Namisaki, T; Noguchi, R; Tsujimoto, T; Uemura, M; Yamazaki, M; Yanase, K; Yoshii, J; Yoshiji, H, 2006) |
| "Pretreatment with pargyline attenuated the MPTP-induced clinical signs, MRI and MRS changes, and the histopathological and immunoreactivity alterations." | 1.32 | Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. ( Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA, 2003) |
| " Pretreatment, cotreatment, or delayed treatment with acetylcholine or choline prevented the adverse effects of DMAE." | 1.32 | The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. ( Buznikov, GA; Lauder, JM; Nikitina, LA; Qiao, D; Seidler, FJ; Slotkin, TA, 2003) |
| "SCA3 or Machado-Joseph disease (MJD) is the commonest dominant inherited ataxia disease, with pathological phenotypes apparent with a CAG triplet repeat length of 61-84." | 1.32 | Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3. ( Cemal, CK; Griffin, JL; Pook, MA, 2004) |
| "Dunning rat prostate cancer cells were injected into the prostate by open surgery." | 1.32 | Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapy. ( Fink, C; Grobholz, R; Heilmann, M; Huber, PE; Kiessling, F; Krix, M; Lichy, MP; Meding, J; Peschke, P; Schlemmer, HP, 2004) |
| "Sandhoff disease is a progressive neurodegenerative disorder caused by mutations in the HEXB gene which encodes for the beta-subunit of beta-hexosaminidase A and B, resulting in ganglioside GM(2) accumulation in the brain." | 1.32 | Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease. ( Bodennec, J; Buccoliero, R; Futerman, AH; Sandhoff, K; Van Echten-Deckert, G, 2004) |
| "Murine trisomy 16 is an animal model of human Down's syndrome." | 1.31 | Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice. ( Allen, DD; Arriagada, C; Cárdenas, AM; Caviedes, P; Caviedes, R; Martín, J; Rapoport, SI, 2000) |
| "Brain cells in Alzheimer's disease (AD) exhibit a membrane defect characterized by accelerated phospholipid turnover." | 1.31 | Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. ( Blusztajn, JK; Farber, SA; Slack, BE, 2000) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| "Fatty liver is known to be associated with increased mortality and morbidity after liver resection." | 1.31 | Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats. ( Horsmans, Y; Lambotte, L; Picard, C; Saliez, A; Sempoux, C; Starkel, P; Van den Berge, V, 2002) |
| "In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development." | 1.31 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002) |
| "3, 1, 3, 10, or 30 mg/kg/day sc for 14 days) attenuated the AF64A-induced cognitive impairment in a dose-dependent manner, producing an inverted U-shaped dose-response function which was optimal at 1." | 1.30 | Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease. ( Bartolomeo, AC; Boast, CA; Morris, H, 1997) |
| " Nicotine enhanced release, with a bell-shaped dose-response curve." | 1.29 | Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function. ( Potter, PE; Thorne, B, 1995) |
| " The results indicate that the TS16 condition in mice significantly modified the cholinergic function in brain, and to a lesser degree in spinal cord, suggesting that the higher gene dosage inherent to the trisomic condition affects cholinergic neurons in different regions of the central nervous system in a differential fashion." | 1.29 | Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). ( Caviedes, P; Caviedes, R; Epstein, CJ; Fiedler, JL; Rapoport, SI, 1994) |
| "Acute pancreatitis was induced by feeding a diet deficient in choline and supplemented with 0." | 1.29 | Action of CCK on CDE diet-induced acute pancreatitis in rats treated with hydrocortisone. ( de Dios, I; Manso, MA; Pescador, R; Rebollo, A, 1995) |
| "Cholinergic markers were decreased in the cerebral cortex of BF-lesioned rats." | 1.28 | Cholecystokinin protects cholinergic neurons against basal forebrain lesion. ( Kubota, K; Sugaya, K; Takahashi, M, 1992) |
| "Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology." | 1.28 | Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. ( Capacio, BR; Koviak, TA; Shih, TM, 1991) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| "Pretreatment with idebenone (10 mg/kg, i." | 1.28 | Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1989) |
| "Cholinergic processes were measured in motor cortex, hippocampus, and striatum of cats in the terminal stages of GM1 gangliosidosis and compared to those of control cats." | 1.27 | Increased acetylcholine synthesis and release in brains of cats with GM1 gangliosidosis. ( Baker, HJ; Connor, DJ; Jope, RS, 1986) |
| "A reversible syndrome of nonoliguric acute renal failure was induced by the intravenous administration of a low dose of mercuric chloride (1." | 1.26 | Phospholipid metabolism during renal regeneration after acute tubular necrosis. ( Dodd, RC; Havener, LJ; Spargo, BH; Toback, FG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (9.52) | 18.7374 |
| 1990's | 24 (5.44) | 18.2507 |
| 2000's | 92 (20.86) | 29.6817 |
| 2010's | 196 (44.44) | 24.3611 |
| 2020's | 87 (19.73) | 2.80 |
| Authors | Studies |
|---|---|
| Mistry, JS | 1 |
| Abraham, DJ | 1 |
| Hanin, I | 8 |
| Grafe, EL | 1 |
| Fontaine, CJ | 1 |
| Thomas, JD | 3 |
| Christie, BR | 1 |
| Kwan, STC | 1 |
| Ricketts, DK | 1 |
| Presswood, BH | 1 |
| Smith, SM | 1 |
| Mooney, SM | 1 |
| Men, H | 1 |
| Young, JL | 1 |
| Zhou, W | 1 |
| Zhang, H | 6 |
| Wang, X | 6 |
| Xu, J | 1 |
| Lin, Q | 1 |
| Tan, Y | 2 |
| Zheng, Y | 1 |
| Cai, L | 1 |
| Lee, N | 1 |
| Heo, YJ | 1 |
| Choi, SE | 1 |
| Jeon, JY | 1 |
| Han, SJ | 1 |
| Kim, DJ | 1 |
| Kang, Y | 1 |
| Lee, KW | 1 |
| Kim, HJ | 2 |
| Wen, F | 1 |
| Bian, D | 1 |
| Wu, X | 2 |
| Liu, R | 1 |
| Wang, C | 1 |
| Gan, J | 1 |
| Herrera-Marcos, LV | 1 |
| Martínez-Beamonte, R | 1 |
| Macías-Herranz, M | 1 |
| Arnal, C | 1 |
| Barranquero, C | 1 |
| Puente-Lanzarote, JJ | 1 |
| Gascón, S | 1 |
| Herrero-Continente, T | 1 |
| Gonzalo-Romeo, G | 1 |
| Alastrué-Vera, V | 1 |
| Gutiérrez-Blázquez, D | 1 |
| Lou-Bonafonte, JM | 1 |
| Surra, JC | 1 |
| Rodríguez-Yoldi, MJ | 1 |
| García-Gil, A | 1 |
| Güemes, A | 1 |
| Osada, J | 1 |
| Carugati, M | 1 |
| Goodlett, CR | 3 |
| Cudd, TA | 3 |
| Washburn, SE | 3 |
| Alshawsh, MA | 1 |
| Alsalahi, A | 1 |
| Alshehade, SA | 1 |
| Saghir, SAM | 1 |
| Ahmeda, AF | 1 |
| Al Zarzour, RH | 1 |
| Mahmoud, AM | 1 |
| Li, C | 1 |
| Zhu, L | 1 |
| Dai, Y | 1 |
| Zhang, Z | 2 |
| Huang, L | 5 |
| Wang, TJ | 1 |
| Fu, P | 1 |
| Li, Y | 3 |
| Wang, J | 4 |
| Jiang, C | 1 |
| Zhu, B | 1 |
| Li, H | 3 |
| Lu, B | 1 |
| Guo, X | 1 |
| Wu, C | 3 |
| Wang, F | 2 |
| Li, Q | 3 |
| Xie, L | 3 |
| Glaser, S | 1 |
| Francis, H | 1 |
| Alpini, G | 1 |
| Lee, GR | 1 |
| Lee, HI | 1 |
| Kim, N | 1 |
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| Morrissey, RB | 1 |
| Donaldson, WE | 1 |
| Simonton, S | 1 |
| Toback, FG | 1 |
| Havener, LJ | 1 |
| Dodd, RC | 1 |
| Spargo, BH | 1 |
| Carroll, PT | 1 |
| Silbergeld, EK | 1 |
| Goldberg, AM | 1 |
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| Lombardi, B | 2 |
| Ballati, L | 1 |
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| Smirnov, VM | 1 |
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| Levy, A | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770] | 140 participants (Anticipated) | Interventional | 2019-10-10 | Active, not recruiting | |||
| The Role of Microbiome Reprogramming on Liver Fat Accumulation[NCT03914495] | 57 participants (Actual) | Interventional | 2019-05-21 | Terminated (stopped due to PI carefully considered multiple factors and decided to close study to any further enrollment.) | |||
| Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan[NCT04671186] | 47 participants (Actual) | Interventional | 2020-09-07 | Completed | |||
| Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery[NCT03391401] | 204 participants (Actual) | Observational | 2018-03-01 | Completed | |||
| Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692] | Phase 3 | 750 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | ||
| Impact of a Home-based Exercise Program on Prognostic Biomarkers in Men With Prostate Cancer[NCT03397030] | 27 participants (Actual) | Interventional | 2017-01-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
30 reviews available for choline and Disease Models, Animal
| Article | Year |
|---|---|
A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; M | 2022 |
Gut Microbiota and Cardiovascular Disease.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cardiovascular Diseases; Carnitine; Choline; Disease | 2020 |
Cholinesterase inhibitors as Alzheimer's therapeutics (Review).
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; Cognition; Dis | 2019 |
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Mo | 2013 |
Prenatal treatment of Down syndrome: a reality?
Topics: Animals; Animals, Newborn; Apigenin; Catechin; Choline; Disease Models, Animal; Down Syndrome; Dyrk | 2014 |
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas | 2014 |
Nutrition implications for fetal alcohol spectrum disorder.
Topics: Alcohol Drinking; Animals; Antioxidants; Brain; Choline; Dietary Supplements; Disease Models, Animal | 2014 |
Investigating the mechanism(s) underlying switching between states in bipolar disorder.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Catecholamines; Choline; Disease Models, Animal; Humans | 2015 |
Neurochemistry of Hypomyelination Investigated with MR Spectroscopy.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Demyelinating Diseases; Disease Models, | 2015 |
Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet.
Topics: Animals; Cardiovascular Diseases; Carnitine; Choline; Diet, Protein-Restricted; Disease Models, Anim | 2015 |
Muscarinic agonists for the treatment of cognition in schizophrenia.
Topics: Animals; Antipsychotic Agents; Choline; Cognition Disorders; Disease Models, Animal; Humans; Muscari | 2008 |
Choline: an essential nutrient for public health.
Topics: Adolescent; Adult; Aged; Animals; Breast Neoplasms; Child; Child, Preschool; Choline; Choline Defici | 2009 |
Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Choline; Disease Models, Animal; Evoked Pot | 2010 |
Novel insights for systemic inflammation in sepsis and hemorrhage.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Choline; Cytokines; Dise | 2010 |
Rett syndrome treatment in mouse models: searching for effective targets and strategies.
Topics: Animals; Anxiety; Choline; Cognition; Disease Models, Animal; Genotype; Methyl-CpG-Binding Protein 2 | 2013 |
Magnetic resonance spectroscopy in animal models of epilepsy.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Choline; Creatine; Disease Models, Animal; Epilepsy; | 2007 |
Nutritional factors in a mouse model of Rett syndrome.
Topics: Acetylcholine; Animals; Brain; Choline; Disease Models, Animal; DNA Methylation; Genes, X-Linked; Hu | 2009 |
Choline analogs as potential tools in developing selective animal models of central cholinergic hypofunction.
Topics: Acetylcholine; Animals; Autonomic Nervous System Diseases; Choline; Choline O-Acetyltransferase; Dis | 1980 |
The AF64A model of cholinergic hypofunction: an update.
Topics: Animals; Aziridines; Brain; Choline; Choline Deficiency; Cholinergic Antagonists; Disease Models, An | 1996 |
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy?
Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic | 1996 |
Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cerebral Co | 1996 |
Possible role of the cholinergic system and disease models.
Topics: Alzheimer Disease; Animals; Brain; Cerebrovascular Circulation; Choline; Cholinesterase Inhibitors; | 1997 |
Cholinergic toxins and Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Humans; Neur | 1992 |
Novel approaches to the pathophysiology of heatstroke: the energy depletion model.
Topics: Adaptation, Physiological; Animals; Body Temperature Regulation; Choline; Cholinergic Fibers; Diseas | 1987 |
Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Amyloid; Animals; Axons; Brain; Cerebral Cortex; Cho | 1985 |
Are the neurochemical and behavioral changes induced by lesions of the nucleus basalis in the rat a model of Alzheimer's disease?
Topics: Alzheimer Disease; Animals; Basal Ganglia; Behavior, Animal; Choline; Choline O-Acetyltransferase; D | 1986 |
Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity.
Topics: Aged; Aging; Aluminum; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Hapl | 1986 |
Neural grafting in animal models of neurodegenerative diseases.
Topics: Aging; Animals; Behavior, Animal; Brain; Brain Diseases; Choline; Corpus Striatum; Denervation; Dise | 1985 |
Relationship of ethanol to choline metabolism in the liver: a review.
Topics: Alcohol Oxidoreductases; Animals; Carbon Radioisotopes; Choline; Choline Deficiency; Disease Models, | 1973 |
1 trial available for choline and Disease Models, Animal
| Article | Year |
|---|---|
Studies on choline chloride in neuropsychiatric disease: human and animal data.
Topics: Animals; Choline; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Dyskinesia, Dru | 1978 |
410 other studies available for choline and Disease Models, Animal
| Article | Year |
|---|---|
Neurochemistry of aging. 1. Toxins for an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Binding, Competitive; Biological Transport; Brain | 1986 |
Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus.
Topics: Animals; Central Nervous System Depressants; Choline; Dentate Gyrus; Disease Models, Animal; Ethanol | 2021 |
Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol-exposed fetal organs.
Topics: Animals; Animals, Newborn; Choline; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders | 2021 |
Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer.
Topics: Animals; Animals, Newborn; Cadmium; Choline; Diet, High-Fat; Diethylnitrosamine; Disease Models, Ani | 2021 |
Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease.
Topics: Amino Acids; Animals; Benzhydryl Compounds; Choline; Cytokines; Diet, High-Fat; Disease Models, Anim | 2022 |
SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice.
Topics: Animals; Choline; Coumarins; Diet; Disease Models, Animal; Down-Regulation; Half-Life; Humans; Lipid | 2022 |
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Topics: Animals; Choline; Diet, High-Fat; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Galec | 2022 |
The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent.
Topics: Animals; Choline; Dietary Supplements; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disord | 2022 |
Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice.
Topics: Acute Disease; Animals; Astrocytes; Brain Injuries; Cerebral Hemorrhage; Choline; Diet; Disease Mode | 2022 |
Indole supplementation ameliorates MCD-induced NASH in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Indoles; In | 2022 |
Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.
Topics: Animals; Choline; Cytoplasmic Dyneins; Diet; Disease Models, Animal; Dyneins; Inflammation; Liver; M | 2022 |
Inhibition of Trimethylamine N-Oxide Attenuates Neointimal Formation Through Reduction of Inflammasome and Oxidative Stress in a Mouse Model of Carotid Artery Ligation.
Topics: Animals; Atherosclerosis; Carotid Arteries; Choline; Disease Models, Animal; Humans; Inflammasomes; | 2023 |
RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling.
Topics: Animals; Carcinoma, Hepatocellular; Choline; DEAD-box RNA Helicases; Diet, High-Fat; Disease Models, | 2023 |
Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice.
Topics: Animals; Choline; Collaborative Cross Mice; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fat | 2022 |
Depletion of hepatic stellate cells inhibits hepatic steatosis in mice.
Topics: Amino Acids; Animals; CD36 Antigens; Choline; Cytokines; Disease Models, Animal; Fatty Acids; Glioto | 2022 |
USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-κB Signaling in Macrophages.
Topics: Acute Disease; Animals; Arginine; Ceruletide; Choline; Cytokines; Deubiquitinating Enzymes; Disease | 2022 |
Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice.
Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Diet, High-Fat; Disease Models, Animal; Di | 2022 |
Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance.
Topics: Animals; Choline; Colitis; Dendritic Cells; Dextran Sulfate; Disease Models, Animal; Enterobacter; I | 2022 |
IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Disease Models, Animal; Hepatitis; Inflamm | 2022 |
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Choline; Creatine; Disease Models, Animal; Disease Progression; G | 2022 |
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
Topics: Ammonia; Animals; Bile Acids and Salts; Bile Ducts; Brain; Choline; Disease Models, Animal; Glutamin | 2022 |
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis | 2023 |
Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation.
Topics: Animals; Choline; Disease Models, Animal; Intestines; Liver; Methionine; Mice; Mice, Inbred C57BL; N | 2023 |
Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Choline; Choline | 2023 |
Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-Fat; Diethylnitrosamine; Diseas | 2023 |
Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast.
Topics: Animals; Antigens; Cell Differentiation; Choline; Disease Models, Animal; Humans; Liver; Liver Cirrh | 2023 |
Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis.
Topics: Adiposity; Animals; Cholesterol Esters; Choline; Disease Models, Animal; Fatty Acid Synthases; Fatty | 2023 |
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla | 2023 |
Chrysin and its nanoliposome ameliorated non-alcoholic steatohepatitis via inhibiting TLR4 signalling pathway.
Topics: Animals; Choline; Diet; Disease Models, Animal; Flavonoids; Liver; Methionine; Mice; Mice, Inbred C5 | 2023 |
Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation.
Topics: Alzheimer Disease; Animals; Basal Forebrain; Choline; Cholinergic Neurons; Dietary Supplements; Dise | 2023 |
Qing-Zhi-Tiao-Gan-Tang (QZTGT) prevents nonalcoholic steatohepatitis (NASH) by expression pattern correction.
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; No | 2023 |
Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency.
Topics: Animals; Choline; Diet; Disease Models, Animal; Mice; Mice, Knockout; Niemann-Pick Disease, Type A; | 2023 |
MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats.
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; N | 2023 |
Endothelial autophagy is not required for liver regeneration after partial hepatectomy in mice with fatty liver.
Topics: Animals; Autophagy; Choline; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Focal Nodula | 2023 |
iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice.
Topics: Animals; Choline; Disease Models, Animal; Inflammation; Isotope Labeling; Liver; Liver Cirrhosis; Me | 2023 |
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline D | 2023 |
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy.
Topics: Alzheimer Disease; Animals; Betaine; Carbon; Choline; Dietary Supplements; Disease Models, Animal; F | 2023 |
Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Choline; Dia | 2023 |
CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response.
Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Liver Cirrhosis; Methionine; Mice; Non-alc | 2024 |
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Choline; Colitis; Colon; Cytidine Diphosphate Choline; | 2023 |
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Forebrain; Choline; Choline O-Acetyltransferase; Dietary Sup | 2023 |
Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production.
Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Hepatitis; Humans; Inflammation; Lactobaci | 2023 |
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Benzenesulfonates; Brain Diseases; Cerebral Cortex | 2019 |
Bioionic Liquid Conjugation as Universal Approach To Engineer Hemostatic Bioadhesives.
Topics: Animals; Biocompatible Materials; Cell Line; Cell Survival; Choline; Disease Models, Animal; Hydroge | 2019 |
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Topics: Animals; Antagomirs; beta Catenin; Choline; Disease Models, Animal; Gene Expression Regulation; Glyc | 2019 |
Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range.
Topics: Alzheimer Disease; Animals; Aziridines; Biological Clocks; Central Nervous System Stimulants; Cholin | 2019 |
Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: Animals; Choline; Disease Models, Animal; Down-Regulation; GTP-Binding Protein alpha Subunits, Gi-Go | 2020 |
Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatectomy; Lipid Metabolism; Liver; Liver Neoplasm | 2020 |
Multi-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism.
Topics: Animals; Atherosclerosis; Choline; Diet; Diet, Atherogenic; Disease Models, Animal; Gene Expression | 2019 |
Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes.
Topics: Amino Acids, Aromatic; Animals; Choline; Chromatography; Disease Models, Animal; Female; Gene Expres | 2019 |
Concomitant memantine and
Topics: Alzheimer Disease; Animals; Animals, Genetically Modified; Biomarkers; Choline; Cognitive Dysfunctio | 2020 |
Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH.
Topics: Age Factors; Animals; Bile Acids and Salts; Choline; Colon; Disease Models, Animal; Dysbiosis; Femal | 2020 |
Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Choline; Cholinergic Agents; Disease Models, Animal | 2020 |
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Topics: Adult; Animals; Choline; Disease Models, Animal; Female; Glutaminase; Hepatocytes; Humans; Lipid Met | 2020 |
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate C | 2020 |
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; | 2020 |
Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH).
Topics: Amino Acids; Animals; CD36 Antigens; Cholesterol; Choline; Choline Deficiency; Diet, High-Fat; Disea | 2020 |
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.
Topics: Animal Feed; Animals; Atherosclerosis; Bacteria; Biomarkers; Carotid Artery Diseases; Choline; Coron | 2021 |
Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome.
Topics: Animals; Caspase 1; Choline; Diet; Disease Models, Animal; DNA, Mitochondrial; Gene Expression Regul | 2020 |
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Down-Regulation; Enzyme Inhi | 2020 |
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; | 2020 |
Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice.
Topics: Alanine Transaminase; Amino Acids; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; B | 2020 |
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Topics: Animals; Arachidonate 12-Lipoxygenase; Choline; Choline Deficiency; Diet; Disease Models, Animal; He | 2020 |
Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats- exploring the comparable benefits of choline and DHA or environmental enrichment.
Topics: Animals; Animals, Newborn; Behavior, Animal; Choline; Diet, High-Fat; Disease Models, Animal; Docosa | 2021 |
Citrus reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet-induced NASH C57BL/6 J mice.
Topics: Animals; Choline; Citrus; Diet, High-Fat; Disease Models, Animal; Fruit; Humans; Liver; Male; Methio | 2020 |
Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation.
Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Chlorogenic Acid | 2020 |
MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Cells, Cultured; Choline; Circadian Rhythm; Diet; Disease | 2020 |
Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calixarenes; Choline; C | 2020 |
Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD.
Topics: Animals; Betaine; Choline; Collagen; Diet; Dietary Supplements; Disease Models, Animal; Hepatocytes; | 2020 |
Insufficient dietary choline aggravates disease severity in a mouse model of
Topics: Animals; Chemokines; Choline; Citrobacter rodentium; Colitis; Colon; Cytokines; Diet; Dietary Supple | 2021 |
Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect.
Topics: Administration, Cutaneous; Animals; Antigens, Neoplasm; Cancer Vaccines; Cell Line, Tumor; Choline; | 2020 |
Automated thermal imaging for the detection of fatty liver disease.
Topics: Algorithms; Animals; Automation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Li | 2020 |
The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice.
Topics: Alanine Transaminase; Amino Acids; Animals; Cell Adhesion; Choline; Diet; Disease Models, Animal; En | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-F | 2020 |
The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model.
Topics: Amino Acids; Animals; Chalcones; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal | 2020 |
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Atherosclerosis; Cardiovascular Diseases; | 2021 |
Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.
Topics: Alkaline Phosphatase; Alleles; Animals; Choline; Choline Deficiency; Diet; Diet, High-Fat; Disease M | 2020 |
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
Topics: Adenine; Albuminuria; Animals; Cardiomegaly; Choline; Disease Models, Animal; Female; Fibroblast Gro | 2021 |
A novel chicken model of fatty liver disease induced by high cholesterol and low choline diets.
Topics: Animals; Chickens; Cholesterol; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Hyperlip | 2021 |
Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of
Topics: Animals; Choline; Diet; Disease Models, Animal; Genes, rRNA; Isoflavones; Liver; Magnetic Resonance | 2021 |
The effect of choline availability from gestation to early development on brain and retina functions and phospholipid composition in a male mouse model.
Topics: Animals; Brain; Choline; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Phosphatidy | 2022 |
Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA
Topics: Animals; Choline; Chromatography, Liquid; Cyclooxygenase 1; Disease Models, Animal; Gene Expression; | 2021 |
SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH).
Topics: Animals; Anti-Inflammatory Agents; Choline; Cinnamates; Depsides; Disease Models, Animal; Liver; Met | 2022 |
BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization.
Topics: Adenoviridae; Animals; Cell Differentiation; Choline; Cytokines; Diet; Disease Models, Animal; Gene | 2021 |
Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics.
Topics: Animals; Antineoplastic Agents; Astragalus Plant; ATP-Binding Cassette Transporters; Cantharidin; Ch | 2021 |
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome.
Topics: Animals; Atherosclerosis; Berberine; Choline; Diet; Disease Models, Animal; Disease Susceptibility; | 2021 |
Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65
Topics: Animals; Biological Products; Choline; Disease Models, Animal; Drug Delivery Systems; Lumefantrine; | 2021 |
Curcumin Potentiates α7 Nicotinic Acetylcholine Receptors and Alleviates Autistic-Like Social Deficits and Brain Oxidative Stress Status in Mice.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autism Spectrum Disorder; A | 2021 |
[Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice].
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; N | 2021 |
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.
Topics: Amino Acids; Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Lipid Met | 2021 |
Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; DNA Methylation; Epige | 2017 |
Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure.
Topics: Animals; Animals, Newborn; Blood Alcohol Content; Choline; Disease Models, Animal; Ethanol; Female; | 2017 |
Alterations in metabolic pathways in stomach of mice infected with Helicobacter pylori.
Topics: Amino Acids; Animals; Choline; Citric Acid Cycle; Disease Models, Animal; Female; Gastric Mucosa; He | 2017 |
Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment.
Topics: Animals; Ascites; Bone Marrow; Cancer-Associated Fibroblasts; Cell Line, Tumor; Choline; Choline Def | 2017 |
Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury.
Topics: Animals; Choline; Choline Deficiency; Chromatography, Liquid; Disease Models, Animal; Gene Expressio | 2017 |
Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity.
Topics: Adiposity; Animals; Blood Glucose; Choline; Diet, High-Fat; Dietary Supplements; Disease Models, Ani | 2017 |
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
Topics: Adipose Tissue; Animals; CD18 Antigens; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Hep | 2017 |
Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Di | 2017 |
Use of immunoproteomics to identify immunogenic proteins in a rat model of acute respiratory distress syndrome.
Topics: Animals; Autoantibodies; Cecum; Choline; Computational Biology; Disease Models, Animal; Gene Express | 2017 |
Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Caspase 3; Chick Embryo; Chickens; Choline; | 2017 |
Supplementary choline attenuates olive oil lipid emulsion-induced enterocyte apoptosis through suppression of CELF1/AIF pathway.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Atrophy; bcl-2-Associated X Protein; Caco-2 Cells; Ca | 2018 |
Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid.
Topics: Animals; Choline; Choline Deficiency; Disease Models, Animal; Fatty Acids; Hepatocytes; Humans; Live | 2017 |
Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting.
Topics: Animals; Choline; Culicidae; Disease Models, Animal; Food; Gene Deletion; Gene Expression Regulation | 2018 |
Neonatal Ethanol and Choline Treatments Alter the Morphology of Developing Rat Hippocampal Pyramidal Neurons in Opposite Directions.
Topics: Animals; Animals, Newborn; CA1 Region, Hippocampal; Cell Size; Choline; Dendrites; Disease Models, A | 2018 |
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.
Topics: Aging; Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Mo | 2018 |
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Mo | 2018 |
Ethanolic extract Ocimum sanctum. Enhances cognitive ability from young adulthood to middle aged mediated by increasing choline acetyl transferase activity in rat model.
Topics: Animals; Choline; Choline O-Acetyltransferase; Cognition; Disease Models, Animal; HEK293 Cells; Huma | 2018 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosa | 2018 |
Effect of weak combined static and extremely low-frequency alternating magnetic fields on spatial memory and brain amyloid-β in two animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Choline; Disease Models, Animal; Magnetic | 2018 |
Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline; Dietary Supplements; Dise | 2018 |
Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway.
Topics: Adenylate Kinase; Animals; Autophagy; Cell Line; Cholestenones; Choline; Diet; Disease Models, Anima | 2018 |
Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe
Topics: Animal Feed; Animals; Aortic Diseases; Atherosclerosis; Bacteria; Cholesterol; Choline; Diet, Wester | 2018 |
Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease.
Topics: Animals; Chelating Agents; Choline; Copper; Copper-Transporting ATPases; Disease Models, Animal; DNA | 2018 |
Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration.
Topics: Animals; Antibody Specificity; Bile Ducts; Cell Adhesion Molecules; Cell Movement; Cell Separation; | 2018 |
[Changes of Brain Proton Magnetic Resonance Spectroscopy Study in Hemorrhagic Shock: An Experimental Study on a Rabbit Model].
Topics: Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Magnetic Resonance Spectroscopy; Pro | 2018 |
Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Choline; Disease Models, Animal; Energy Met | 2019 |
Choline Rescues Behavioural Deficits in a Mouse Model of Rett Syndrome by Modulating Neuronal Plasticity.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Choline; Dendritic Spines; Dietary Supplements; Disease | 2019 |
Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model.
Topics: Animals; Antioxidants; Apoptosis; Choline; Diet; Disease Models, Animal; Drugs, Chinese Herbal; Fema | 2018 |
Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts.
Topics: Animal Feed; Animals; Betaine; Biomarkers; Blood Glucose; Cell Line, Tumor; Choline; Diabetes, Gesta | 2018 |
De novo NAD
Topics: Animals; Caenorhabditis elegans; Carboxy-Lyases; Cell Line; Choline; Conserved Sequence; Disease Mod | 2018 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy.
Topics: Anhedonia; Animals; Choline; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; | 2019 |
Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations.
Topics: Alzheimer Disease; Animals; Brain; Choline; Dietary Supplements; Disease Models, Animal; Female; Hom | 2020 |
microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO.
Topics: Animals; Atherosclerosis; Chlorocebus aethiops; Choline; Cohort Studies; Collaborative Cross Mice; D | 2019 |
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Micro | 2019 |
Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Choline; Disease Models, Animal; DNA Methylation; Epigenesis, | 2019 |
Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; Choline; Diet, | 2019 |
Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena.
Topics: Amino Acids, Branched-Chain; Animals; Choline; Creatine; Disease Models, Animal; Environment; Gastro | 2019 |
Cholinesterase's activities of infected mice by Brucella ovis.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brucella ovis; Brucellosis; Butyrylcholinesterase; Cat | 2019 |
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
Topics: Animals; Atherosclerosis; Choline; Disease Models, Animal; Lipid Metabolism; Methylamines; Mice; Mic | 2019 |
Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model.
Topics: Animals; Choline; Craniofacial Abnormalities; Disease Models, Animal; Ethanol; Female; Fetal Alcohol | 2019 |
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome.
Topics: Animals; Basal Forebrain; Choline; Cholinergic Neurons; Dietary Supplements; Disease Models, Animal; | 2019 |
Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Models, A | 2019 |
Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Choline; Cholinergic N | 2019 |
Choline-deficient-diet Decreases Fibroblasts in the Circulating Tumor Cell (CTC) Microenvironment.
Topics: Animals; Cell Line, Tumor; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fibroblasts; G | 2019 |
Phospholipase D-mTOR signaling is compromised in a rat model of depression.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Brain; Choline; Clomipramine; Depressio | 2013 |
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.
Topics: Animals; Carbon; Choline; Choline Deficiency; Cystathionine beta-Synthase; Disease Models, Animal; D | 2013 |
Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.
Topics: Animals; Antibodies, Antinuclear; Betaine; CD40 Ligand; Choline; Coenzymes; Diet; Disease Models, An | 2013 |
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Choline; Disease Models, Animal; Doublecortin D | 2013 |
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Cre | 2013 |
[Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice].
Topics: Animals; Anticonvulsants; Choline; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2013 |
Neural metabolite changes in corpus striatum after rat multipotent mesenchymal stem cells transplanted in hemiparkinsonian rats by magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Choline; Corpus Striatum; Creatine; Dis | 2013 |
Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis.
Topics: Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Apoptosis; Choline; Culture Media; Disea | 2013 |
Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods.
Topics: Animals; Aspartic Acid; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Frontal Lobe; Fu | 2014 |
Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1.
Topics: Animals; Ataxin-1; Ataxins; Cerebellum; Choline; Disease Models, Animal; Disease Progression; Gene K | 2013 |
Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.
Topics: Age Factors; Animals; Cell Count; Cell Size; Choline; Choline O-Acetyltransferase; Cholinergic Fiber | 2014 |
Neurochemistry in shiverer mouse depicted on MR spectroscopy.
Topics: Amino Acid Transport Systems, Acidic; Analysis of Variance; Animals; Antiporters; Aspartic Acid; Bra | 2014 |
Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br | 2014 |
High-resolution magic angle spinning (1)H magnetic resonance spectroscopy detects choline as a biomarker in a swine obstructive chronic pancreatitis model at an early stage.
Topics: Animals; Biomarkers; Choline; Disease Models, Animal; Metabolomics; Nuclear Magnetic Resonance, Biom | 2014 |
Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Choline; Diet | 2014 |
Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease.
Topics: Animals; Choline; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes | 2014 |
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
Topics: Adipogenesis; Adipose Tissue; Animals; Choline; Disease Models, Animal; Fatty Acids; Fatty Acids, No | 2014 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease M | 2014 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; | 2014 |
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.
Topics: Aging; Animals; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Supple | 2014 |
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
Topics: Animals; Atherosclerosis; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Choline; Diet, High-Fat; D | 2014 |
Altered sigma-1 receptor expression in two animal models of cognitive impairment.
Topics: Animals; Blotting, Western; Choline; Cognition Disorders; Disease Models, Animal; Kinetics; Male; Ra | 2015 |
Choline kinase inhibition in rheumatoid arthritis.
Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Butanes; Cell Movement; Cell Proliferation; Cells, Cultur | 2015 |
High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Choline; Disease Models, Animal; Dose-Respons | 2015 |
Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb.
Topics: Animals; Aspartic Acid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Choline; Corpus Stri | 2014 |
Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats.
Topics: Acetylcholine; Animals; Blood Pressure; Chlorpheniramine; Choline; Disease Models, Animal; Dose-Resp | 2015 |
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Central Nervo | 2015 |
Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus.
Topics: Age Factors; Animals; Binding Sites; Brain-Derived Neurotrophic Factor; Choline; Chromatin Assembly | 2015 |
Catalpol regulates cholinergic nerve system function through effect on choline acetyl-transferase not M receptor affinity.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Disease Models, A | 2015 |
The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Autistic Disorder; Behavior, Animal; Choline; Dise | 2015 |
Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: a 3D, multivoxel proton magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Biomarkers; Central Nervous System Diseases; Cerebral Cortex; Choline; Creat | 2015 |
Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model.
Topics: Animals; Cell Cycle; Choline; Choline Deficiency; Disease Models, Animal; Disease Progression; Food, | 2015 |
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline | 2015 |
Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats.
Topics: Animals; Axons; Behavior, Animal; Choline; Disease Models, Animal; Fibroblast Growth Factor 2; Hydro | 2015 |
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Cuprizone; Demyelinating Diseases; Dipep | 2015 |
Dietary Supplementation of Genistein Alleviates Liver Inflammation and Fibrosis Mediated by a Methionine-Choline-Deficient Diet in db/db Mice.
Topics: Animals; Choline; Diet; Dietary Supplements; Disease Models, Animal; Genistein; Humans; Liver; Liver | 2015 |
Choline Alleviates Parenteral Nutrition-Associated Duodenal Motility Disorder in Infant Rats.
Topics: Animals; Animals, Newborn; Betaine; Choline; Disease Models, Animal; Duodenum; Gastrointestinal Moti | 2016 |
Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model.
Topics: Animals; Aspartic Acid; Atropine; Behavior, Animal; Brain; Brain Edema; Choline; Cholinesterase Reac | 2015 |
Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Choline; Choline Deficiency; Disease Models, Animal; Docosahexaenoic A | 2015 |
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver | 2015 |
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Choline; Diet; Disease Models, Animal; F | 2015 |
Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig.
Topics: Animals; Animals, Newborn; Brain; Choline; Choline Deficiency; Diet; Diffusion Tensor Imaging; Disea | 2016 |
Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Deuterium; Disease Models, Animal; Female; Fragile X | 2015 |
Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver | 2015 |
Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF-α, and IL-1β.
Topics: Animals; Body Weight; Catalase; Choline; Cystine; Diet; Disease Models, Animal; Interleukin-1beta; L | 2015 |
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniec | 2015 |
Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.
Topics: Animals; Brain; Choline; Convulsants; Disease Models, Animal; Electrochemistry; Electron Transport C | 2015 |
Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome.
Topics: Age Factors; Aging; Animals; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Synd | 2016 |
Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Choline; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Hum | 2016 |
Haemophilus influenzae LicB contributes to lung damage in an aged mice co-infection model.
Topics: Age Factors; Amino Acid Sequence; Animals; Bacterial Proteins; Choline; Coinfection; Disease Models, | 2016 |
Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Choline; Disease Models, | 2015 |
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi | 2016 |
A Dual Tracer 18F-FCH/18F-FDG PET Imaging of an Orthotopic Brain Tumor Xenograft Model.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Disease Models, Animal; Fluorodeoxyglucose F18; | 2016 |
Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸F-fluoromethylcholine.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Choline; Cytokines; Diabetes Mellitus, | 2016 |
Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease.
Topics: Animals; Choline; Diet; Disease Models, Animal; Follow-Up Studies; Lipotropic Agents; Liver; Male; N | 2016 |
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatitis; Interleukin-17; Macrophages; Male; Methio | 2016 |
Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB.
Topics: Animals; Aorta; Aortitis; Atherosclerosis; Cell Adhesion; Cells, Cultured; Choline; Coculture Techni | 2016 |
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Choline; Choline Deficiency; Diet; Disease Mode | 2016 |
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Case-Control Studies; CD4-Positive T-Lymphocytes | 2016 |
Concomitants of alcoholism: differential effects of thiamine deficiency, liver damage, and food deprivation on the rat brain in vivo.
Topics: Alcoholism; Analysis of Variance; Animals; Brain; Choline; Disease Models, Animal; Ethanol; Food Dep | 2016 |
MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; | 2016 |
Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Topics: Animals; Bupropion; Choline; Choline Deficiency; Cytochrome P-450 CYP2B1; Diet, High-Fat; Disease Mo | 2016 |
Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.
Topics: Animals; CD11b Antigen; Cell Count; Choline; Concanavalin A; Disease Models, Animal; Hepatitis, Auto | 2017 |
Effects of hypotension and/or hypocapnia during sevoflurane anesthesia on perfusion and metabolites in the developing brain of piglets-a blinded randomized study.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Female; Hyp | 2016 |
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver | 2016 |
Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Choline; Dietary Supplements; Disease Models, Animal; | 2016 |
Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis.
Topics: Animals; Carcinogenesis; Choline; Disease Models, Animal; Gastritis; Glycolysis; Humans; Magnetic Re | 2016 |
Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats.
Topics: Animals; Brain; Cell Line, Tumor; Choline; Diagnosis, Differential; Disease Models, Animal; Female; | 2016 |
Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.
Topics: Animals; Choline; Copper; Dietary Supplements; Disease Models, Animal; DNA Methylation; Epigenomics; | 2016 |
Effects of choline treatment in concentrations of serum matrix metalloproteinases (MMPs), MMP tissue inhibitors (TIMPs) and immunoglobulins in an experimental model of canine sepsis.
Topics: Animals; C-Reactive Protein; Choline; Disease Models, Animal; Dogs; Endotoxemia; Immunoglobulin G; I | 2016 |
Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs.
Topics: Age Factors; Animals; Binge Drinking; Brain; Choline; Disease Models, Animal; Female; Male; Neuropro | 2016 |
Assessing remyelination - metabolic labeling of myelin in an animal model of multiple sclerosis.
Topics: Alkynes; Animals; Cell Nucleolus; Choline; Disease Models, Animal; Encephalomyelitis, Autoimmune, Ex | 2016 |
Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring.
Topics: Animals; Attention; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Su | 2017 |
Choline Protects Against Intestinal Failure-Associated Liver Disease in Parenteral Nutrition-Fed Immature Rats.
Topics: Animals; Choline; Disease Models, Animal; Intestinal Diseases; Intestines; Lipotropic Agents; Male; | 2018 |
A silk peptide fraction restores cognitive function in AF64A-induced Alzheimer disease model rats by increasing expression of choline acetyltransferase gene.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Cell Line, Tumor; Choline; Choline O-Ace | 2017 |
Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models.
Topics: Alanine Transaminase; Animals; Bacteroidetes; Cholesterol; Choline; Clostridiales; Diet; Diet, High- | 2017 |
Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.
Topics: Amylases; Animals; Ceruletide; Choline; Clusterin; delta-1-Pyrroline-5-Carboxylate Reductase; Diseas | 2017 |
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Topics: Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Choline; Diet, | 2017 |
Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Animals, Newborn; Choline; | 2017 |
A compromised liver alters polychlorinated biphenyl-mediated toxicity.
Topics: Adipokines; Animals; Aroclors; Biomarkers; Blood Glucose; Cardiovascular Diseases; Choline; Diet; Di | 2017 |
Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Biomarkers; Choline; Disease Models, Animal; Female; | 2017 |
Choline ameliorates cardiovascular damage by improving vagal activity and inhibiting the inflammatory response in spontaneously hypertensive rats.
Topics: Animals; Baroreflex; Cardiomegaly; Cardiovascular Diseases; Choline; Cytokines; Disease Models, Anim | 2017 |
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Topics: Animals; Choline; Disease Models, Animal; Homocystinuria; Humans; Liver; Metabolomics; Mice; Mice, K | 2017 |
Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline.
Topics: Administration, Oral; Animals; Behavior, Animal; Body Weight; Brain; Choline; Disease Models, Animal | 2008 |
Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury.
Topics: Animals; Brain Injuries; Choline; Dietary Supplements; Disease Models, Animal; Male; Maze Learning; | 2008 |
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatine; | 2008 |
Effects of postnatal dietary choline supplementation on motor regional brain volume and growth factor expression in a mouse model of Rett syndrome.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Choline; Disease Models, Animal; Enzyme-Linked I | 2008 |
Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration.
Topics: Age Factors; Alcohols; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weigh | 2008 |
Time-dependent alterations of cholinergic markers after experimental traumatic brain injury.
Topics: Animals; Autoradiography; Brain; Brain Injuries; Choline; Disease Models, Animal; Male; Rats; Rats, | 2008 |
Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo.
Topics: Animals; Aspartic Acid; Cerebellum; Choline; Creatine; Disease Models, Animal; Magnetic Resonance Im | 2008 |
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model.
Topics: Amino Acids; Animals; Blotting, Western; Choline; Choline Deficiency; Diet; Disease Models, Animal; | 2010 |
Proton magnetic resonance spectroscopy revealed choline reduction in the visual cortex in an experimental model of chronic glaucoma.
Topics: Animals; Choline; Chronic Disease; Disease Models, Animal; Female; Glaucoma, Open-Angle; Glutamic Ac | 2009 |
Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation.
Topics: Age Factors; Animals; Animals, Newborn; Aspartic Acid; Brain; Choline; Creatine; Dietary Supplements | 2009 |
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.
Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Dise | 2008 |
Choline produces antiarrhythmic actions in animal models by cardiac M3 receptors: improvement of intracellular Ca2+ handling as a common mechanism.
Topics: Aconitine; Animals; Arrhythmias, Cardiac; Calcium; Choline; Disease Models, Animal; Female; Guinea P | 2008 |
Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.
Topics: Animals; Behavior, Animal; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Choline; Corpus Striatum; | 2009 |
Characterization of preclinical models of prostate cancer using PET-based molecular imaging.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Line, Tumor; Choline; Disease Models, Anim | 2009 |
In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Disease Models, Animal; Female; Ino | 2009 |
Choline supplementation reduces oxidative stress in mouse model of allergic airway disease.
Topics: Administration, Inhalation; Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage | 2009 |
Temporal and regional changes after focal traumatic brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline; | 2010 |
OpuC--an ABC transporter that is associated with Staphylococcus aureus pathogenesis.
Topics: Adaptor Proteins, Signal Transducing; Animals; ATP-Binding Cassette Transporters; Bacterial Adhesion | 2009 |
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Apoptosis; Choline; Disease Models, Animal; Fatty Liver; Inflammation; Interle | 2009 |
Rodent rhabdomyosarcoma: comparison between total choline concentration at H-MRS and [18F]-fluoromethylcholine uptake at PET using accurate methods for collecting data.
Topics: Animals; Choline; Disease Models, Animal; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; P | 2010 |
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Inflammation; Liver Ci | 2010 |
Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice.
Topics: Acetylcholine; Analysis of Variance; Animals; Choline; Corpus Striatum; Disease Models, Animal; Ener | 2010 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Imm | 2010 |
Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression.
Topics: Animals; Arrhythmias, Cardiac; Choline; Connexin 43; Cyclooxygenase 2; Disease Models, Animal; Hemod | 2010 |
[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats].
Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Choline; Choline Deficiency; Diet; Disease Models, | 2010 |
Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome.
Topics: Aging; Animals; Attention; Choline; Cognition; Dietary Supplements; Disease Models, Animal; Down Syn | 2010 |
Desipramine attenuates forced swim test-induced behavioral and neurochemical alterations in mice: an in vivo(1)H-MRS study at 9.4T.
Topics: Animals; Behavior, Animal; Brain Chemistry; Choline; Creatine; Desipramine; Disease Models, Animal; | 2010 |
Early monitoring of external radiation therapy by [18F]-fluoromethylcholine positron emission tomography and 3-T proton magnetic resonance spectroscopy: an experimental study in a rodent rhabdomyosarcoma model.
Topics: Alginates; Animals; Biological Transport; Choline; Disease Models, Animal; Glucuronic Acid; Hexuroni | 2010 |
Effects of postnatal dietary choline manipulation against MK-801 neurotoxicity in pre- and postadolescent rats.
Topics: Animals; Animals, Newborn; Brain; Choline; Cytoprotection; Dietary Supplements; Disease Models, Anim | 2010 |
Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Binding Sites; Calc | 2010 |
Assessment of metabolic changes in the striatum of a MPTP-intoxicated canine model: in vivo ¹H-MRS study of an animal model for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Choline; Corpus Striatum; Crea | 2011 |
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline; Choline Deficiency; | 2011 |
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Def | 2011 |
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem | 2011 |
Diet composition exacerbates or attenuates soman toxicity in rats: implied metabolic control of nerve agent toxicity.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Body Weight; Chemical Warfare A | 2011 |
Cholinergic hypofunction in MeCP2-308 mice: beneficial neurobehavioural effects of neonatal choline supplementation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Choline; Choline O-Acetyltransferase; C | 2011 |
Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver.
Topics: Animals; Betaine; Choline; Dietary Fats; Dietary Sucrose; Dietary Supplements; Disease Models, Anima | 2011 |
CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves.
Topics: Administration, Cutaneous; Animals; Choline; Cytidine; Cytidine Diphosphate Choline; Disease Models, | 2011 |
Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression.
Topics: Animals; Choline; Depression; Disease Models, Animal; Electroconvulsive Therapy; gamma-Aminobutyric | 2012 |
The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Choline; Cytidine Diphosphate Choline; | 2011 |
Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.
Topics: Animals; Cell Movement; Cell Proliferation; Choline; Cytokines; Diet; Disease Models, Animal; Ethion | 2011 |
Interaction between total body gamma-irradiation and choline deficiency triggers immediate modulation of choline and choline-containing moieties.
Topics: Adipogenesis; Animals; Brain; Choline; Choline Deficiency; Choline O-Acetyltransferase; Disease Mode | 2011 |
Tianeptine reverses stress-induced asymmetrical hippocampal volume and N-acetylaspartate loss in rats: an in vivo study.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Aspartic Acid; Choline; Chromatogra | 2011 |
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice.
Topics: Animals; Choline; Choline-Phosphate Cytidylyltransferase; Dietary Fats; Dietary Supplements; Disease | 2012 |
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Energy Intake; Folic Acid; Folic | 2012 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto | 2012 |
Evaluation of deuterated 18F- and 11C-labeled choline analogs for cancer detection by positron emission tomography.
Topics: Animals; Carbon Radioisotopes; Cell Line, Tumor; Choline; Deuterium; Disease Models, Animal; Fluorod | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; | 2012 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Emb | 2012 |
Systematic evaluation of magnetic resonance imaging and spectroscopy techniques for imaging a transgenic model of Alzheimer's disease (AβPP/PS1).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Brain; Cell Proliferation; Choline; C | 2012 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorode | 2012 |
Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury.
Topics: Animals; Axotomy; Choline; Cytidine; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Ther | 2012 |
Quantification of macrovesicular and microvesicular hepatic steatosis in rats using 3.0-T ¹H-magnetic resonance spectroscopy.
Topics: Animals; Area Under Curve; Biomarkers; Biopsy; Choline; Choline Deficiency; Disease Models, Animal; | 2012 |
Supplemental choline during the periweaning period protects against trace conditioning impairments attributable to post-training ethanol exposure in adolescent rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Central Nervous System Depressants; Ch | 2012 |
Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Autoradiography; Chemotaxis, Leukocyte; Choli | 2012 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin | 2012 |
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase | 2012 |
Postnatal choline levels mediate cognitive deficits in a rat model of schizophrenia.
Topics: Animals; Choline; Choline Deficiency; Cognition Disorders; Disease Models, Animal; Dizocilpine Malea | 2012 |
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Cre | 2012 |
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Beh | 2013 |
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping | 2013 |
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intracellular Signa | 2013 |
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production.
Topics: Animals; Chemokine CCL2; Chemokine CXCL10; Choline; Diet; Disease Models, Animal; Fatty Liver; Femal | 2012 |
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Topics: Animals; Biomarkers; Choline; Cysteine; Disease Models, Animal; Folic Acid Deficiency; Heterozygote; | 2013 |
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
Topics: Animals; Anti-Inflammatory Agents; CD3 Complex; Cell Polarity; Choline; Cognition Disorders; Disease | 2013 |
Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.
Topics: Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; C | 2013 |
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice.
Topics: Animals; Betaine; Choline; Craniofacial Abnormalities; Dietary Supplements; Disease Models, Animal; | 2013 |
Usefulness of 11C-choline positron emission tomography for genital chlamydial infection assessment in a BALB/c murine model.
Topics: Animals; Carbon Radioisotopes; Chlamydia Infections; Chlamydia muridarum; Choline; Disease Models, A | 2013 |
Neurovirulence depends on virus input titer in brain in feline immunodeficiency virus infection: evidence for activation of innate immunity and neuronal injury.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain; Cats; CD4-Positive T-Lymphocytes; Cells, Cultured; | 2002 |
Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors.
Topics: Animals; Cell Line; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Syndrome; Fem | 2002 |
Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo.
Topics: Animals; Apoptosis; Aziridines; Brain Ischemia; Cells, Cultured; Choline; Dicumarol; Disease Models, | 2003 |
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus S | 2003 |
Mice transgenic for exon 1 of Huntington's disease: properties of cholinergic and dopaminergic pre-synaptic function in the striatum.
Topics: Acetylcholine; Animals; Calcium; Choline; Choline O-Acetyltransferase; Corpus Striatum; Disease Mode | 2003 |
The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity.
Topics: Acetylcholine; Animals; Antidepressive Agents; Cell Membrane; Choline; Deanol; Disease Models, Anima | 2003 |
Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3.
Topics: Animals; Ataxin-3; Brain; Cerebellum; Choline; Disease Models, Animal; gamma-Aminobutyric Acid; Gluc | 2004 |
Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapy.
Topics: Animals; Antigens, CD34; Choline; Creatine; Disease Models, Animal; Immunohistochemistry; Magnetic R | 2004 |
Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease.
Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Brain Chemistry; Cats; Choline; Creatine; Diseas | 2004 |
Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aziridines; Cell Death; Choline; Choline O-Acetyl | 2004 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
[11C]Choline as a PET biomarker for assessment of prostate cancer tumor models.
Topics: Animals; Carbon Radioisotopes; Choline; Disease Models, Animal; Humans; Male; Mice; Positron-Emissio | 2004 |
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.
Topics: Acute Disease; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chronic Disease; Disease Mode | 2004 |
Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease.
Topics: Animals; beta-N-Acetylhexosaminidases; Brain; Carbon Radioisotopes; CDPdiacylglycerol-Serine O-Phosp | 2004 |
Glycosaminoglycan C3 protects against AF64A-induced cholinotoxicity in a dose-dependent and time-dependent manner.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Aziridines; Cell Death; Choline; Choline O-Acetylt | 2004 |
CPP and amlodipine alter the decrease in basal acetylcholine and choline release by audiogenic stimulus in hippocampus of ethanol-withdrawn rats in vivo.
Topics: Acetylcholine; Acoustic Stimulation; Alcohol-Induced Disorders, Nervous System; Amlodipine; Animals; | 2004 |
Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Brain Stem; Cerebra | 2005 |
Antinociceptive effects of choline against acute and inflammatory pain.
Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm | 2005 |
Relationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model.
Topics: Animals; Choline; Creatine; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Hydrog | 2005 |
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Aspartic Acid; Brain Mapping; Calcium-Binding Proteins; Capsid Prote | 2005 |
MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy.
Topics: Alanine; Amino Acids; Animals; Brain; Brain Diseases, Metabolic; Brain Edema; Carbon Radioisotopes; | 2005 |
In vivo detection of metabolic changes by 1H-MRS in the DEN-induced hepatocellular carcinoma in Wistar rat.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, Animal | 2005 |
CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cholesterol; Choline; Cytidine Diphosphate Choline | 2005 |
Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model.
Topics: Animals; Choline; Choline Deficiency; Deuterium; Diet; Disease Models, Animal; Fatty Liver; Lipid Me | 2005 |
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Hepatitis; | 2005 |
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2006 |
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Li | 2006 |
Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling.
Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Function, Left; Atrial Function, Right; C | 2006 |
Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.
Topics: Animals; Carcinoma, Hepatocellular; Choline; Disease Models, Animal; Disease Progression; Fatty Live | 2006 |
Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.
Topics: Acetates; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Choline; Co | 2006 |
Acetylcholine and choline dynamics provide early and late markers of traumatic brain injury.
Topics: Acetylcholine; Analysis of Variance; Animals; Brain Injuries; Choline; Choline O-Acetyltransferase; | 2006 |
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models, | 2006 |
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
Topics: Animals; Chemokine CCL2; Chemokine CCL4; Choline; Choline Deficiency; Cyclooxygenase 2; Diet; Diseas | 2007 |
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
Topics: Animal Feed; Animals; Choline; Collagen Type I; Collagen Type I, alpha 1 Chain; Diabetes Mellitus, T | 2007 |
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Aziridines; Cell Differentiation; Choline; Colitis | 2007 |
Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
Topics: Animals; Anti-Bacterial Agents; Bacteriolysis; Ceftriaxone; Cell Wall; Cerebrospinal Fluid; Choline; | 2007 |
Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome.
Topics: Acetylcholine; Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Brain; Choline; Di | 2007 |
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Choline; Cytochrome P-450 CYP2E1; Diacylglycerol O | 2007 |
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.
Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models, | 2007 |
Effect of choline chloride in allergen-induced mouse model of airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Choline; Diseas | 2007 |
Effects of lipid-supplemented total parenteral nutrition on fatty liver disease in a premature neonatal piglet model.
Topics: Animals; Animals, Newborn; Bilirubin; Choline; Dietary Supplements; Disease Models, Animal; Fatty Ac | 2008 |
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; In | 2007 |
Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high-resolution magic angle spinning 1H nuclear magnetic resonance and principal components analysis.
Topics: Animals; Choline; Chronic Disease; Diagnosis, Differential; Disease Models, Animal; Lactic Acid; Lip | 2007 |
The role of the nucleus basalis of Meynert and reticular thalamic nucleus in pathogenesis of genetically determined absence epilepsy in rats: a lesion study.
Topics: Animals; Antibodies, Monoclonal; Aziridines; Basal Nucleus of Meynert; Behavior, Animal; Choline; Ch | 2007 |
Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model.
Topics: Animals; Choline; Colorectal Neoplasms; Diffusion Magnetic Resonance Imaging; Disease Models, Animal | 2007 |
Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis.
Topics: Animals; Aziridines; CD4-Positive T-Lymphocytes; Choline; Chronic Disease; Colitis, Ulcerative; Croh | 2007 |
Effects of rosiglitazone on methionine-choline deficient diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline; Diet; Disease Models, Animal; Fatty Liver | 2007 |
Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.
Topics: Adrenal Glands; Animals; Atropine Derivatives; Autonomic Nervous System; Central Nervous System; Cho | 2008 |
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated | 2008 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode | 2008 |
Essential role of choline for pneumococcal virulence in an experimental model of meningitis.
Topics: Animals; Cell Wall; Choline; Cytokines; Disease Models, Animal; Interleukin-10; Matrix Metalloprotei | 2008 |
Magnetic resonance imaging and spectroscopy in a mouse model of schizophrenia.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Disease Models, Animal; Image Interpretation, Comp | 2008 |
Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Choline; | 2008 |
[Estimation of postmortem interval with multivoxel-voxel proton 1H-MR spectroscopy].
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Disease Models, Animal; Embolism, Air; | 2007 |
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Choline; Choline Kinase; Disease Models, Animal; Gene Ex | 2008 |
MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.
Topics: Animals; Aziridines; Behavior, Animal; Brain; Carbon Isotopes; Choline; Disease Models, Animal; Dose | 2008 |
Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy.
Topics: Acetylcholinesterase; Aging; Animals; Brain Chemistry; Choline; Chronic Disease; Disease Models, Ani | 1984 |
Serum phospholipase A2 in diet-induced pancreatitis.
Topics: Acute Disease; Amylases; Animals; Choline; Diet; Disease Models, Animal; Ethionine; Female; Lipase; | 1984 |
Development and use of pharmacological probes of the CNS in man: evidence of cholinergic abnormality in primary affective illness.
Topics: Acetylcholine; Arecoline; Central Nervous System; Choline; Disease Models, Animal; Dose-Response Rel | 1980 |
Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Electric Sti | 1995 |
Nicotinamide megadosing increases hepatic poly(ADP-ribose) levels in choline-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Choline; Choline Deficiency; Disease Models, An | 1995 |
Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome).
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cells, Cultured; Central Nervous System; Choline; Dise | 1994 |
Sleep-wake disturbances in an animal model of chronic cholinergic insufficiency.
Topics: Acetylation; Acetylcholine; Animals; Choline; Choline Deficiency; Circadian Rhythm; Darkness; Diseas | 1993 |
Action of CCK on CDE diet-induced acute pancreatitis in rats treated with hydrocortisone.
Topics: Amylases; Analysis of Variance; Animals; Antimetabolites; Benzodiazepinones; Choline; Devazepide; Di | 1995 |
Contribution of shrinkage of extracellular space to extracellular K+ accumulation in myocardial ischaemia of the rabbit.
Topics: Action Potentials; Animals; Choline; Disease Models, Animal; Extracellular Space; Myocardial Ischemi | 1996 |
The hypocholesterolemic and antiatherogenic effects of topically applied phosphatidylcholine in rabbits with heritable hypercholesterolemia.
Topics: Administration, Cutaneous; Animals; Anticholesteremic Agents; Aorta, Thoracic; Arteriosclerosis; Cho | 1996 |
Age-dependent effect of AF64A on cholinergic activity in the septo-hippocampal pathway of the rat brain: decreased responsiveness in aged rats.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Aziridines; Choline; Choline O-Acetyltransf | 1996 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; | 1997 |
Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Arecoline; Aziridines; Brain; Brain Mapping; Cerebral Cortex; Choline; D | 1997 |
Effects of S-8510, a novel benzodiazepine receptor partial inverse agonist, on basal forebrain lesioning-induced dysfunction in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Benzodiazepines; Choline; Choline O-Acetyltransferase; Di | 1998 |
Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Disease Models, Animal; Down Syndrome; Female; Ino | 2000 |
Cholinergic influence on vestibular stimulation-induced locus coeruleus inhibition in rats.
Topics: Animals; Aziridines; Caloric Tests; Choline; Cholinergic Fibers; Disease Models, Animal; Electrodes, | 2000 |
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cerebral Cortex; Choline; Choline O-Acetyltran | 2000 |
Dimebon improves learning in animals with experimental Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Choline; Cholinesterase Inhibitors; Dise | 2000 |
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate | 2000 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
alpha-tocopherol improves impaired physiology of rat type II pneumocytes isolated from experimentally injured lungs.
Topics: Administration, Inhalation; Animals; Antioxidants; Bronchitis; Bronchoalveolar Lavage Fluid; Cell Co | 2000 |
In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development.
Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Disease Models, Ani | 2000 |
In vivo and in vitro proton NMR spectroscopic studies of thiamine-deficient rat brains.
Topics: Animals; Brain; Choline; Disease Models, Animal; Energy Metabolism; Glycerylphosphorylcholine; Magne | 2001 |
Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome.
Topics: Acetylcholine; Animals; Choline; Disease Models, Animal; Female; Injections, Intraperitoneal; Isopro | 2001 |
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Anesthetics, Inhalation; Animals; Choline; Cholinesteras | 2001 |
Investigation of skeletal muscle denervation and reinnervation using magnetic resonance spectroscopy.
Topics: Action Potentials; Analysis of Variance; Animals; Choline; Disease Models, Animal; Electromyography; | 2001 |
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.
Topics: Acetylcholine; Animals; Calcium; Calcium Signaling; Cell Culture Techniques; Cell Line, Transformed; | 2002 |
Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
Topics: Animal Feed; Animals; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cholesterol; Choline | 2002 |
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D | 2002 |
[Metabolic disorders in experimental hepatic insufficiency and parenteral feeding].
Topics: 5-Hydroxytryptophan; Amino Acids; Ammonia; Animals; Blood Coagulation; Blood Transfusion; Choline; D | 1977 |
Reagin-mediated asthma in rhesus monkeys and relation to bronchial cell histamine release and airway reactivity to carbocholine.
Topics: Aerosols; Animals; Antibodies; Antigens; Ascaris; Asthma; Bronchi; Choline; Disease Models, Animal; | 1976 |
Effect of 2-dimethylaminoethanol in kainate-lesioned rat striatum: anomaly in the radioenzymatic assay of acetylcholine.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Chromatography, Gas; Corpus Striatum; Deanol; Dise | 1978 |
Effects of diethylcholine in two animal models of Parkinsonism tremors.
Topics: Animals; Brain Chemistry; Carbachol; Choline; Disease Models, Animal; Male; Mice; Parkinson Disease, | 1979 |
Cholesteremia in Japanese quail: response to a mixture of vitamins C and E and choline chloride.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Ascorbic Acid; Cholesterol; Cholesterol, Dietary; Cholin | 1979 |
Choline chloride in animal models of tardive dyskinesia.
Topics: Animals; Apomorphine; Choline; Disease Models, Animal; Dyskinesia, Drug-Induced; Haloperidol; Humans | 1978 |
Cholinergic stimulation of the caudate nucleus in rats: a model of Parkinson's disease.
Topics: Animals; Caudate Nucleus; Choline; Disease Models, Animal; Injections; Male; Parasympathomimetics; P | 1978 |
Phospholipid metabolism during renal regeneration after acute tubular necrosis.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cell Membrane; Choline; Cytidine Diphosphate Chol | 1977 |
Alteration of central cholinergic function by chronic lead acetate exposure.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cerebral Cortex; Choline; Choline Kinase; Choline O-Ac | 1977 |
Regional and subcellular distribution and kinetic properties of rat brain choline acetyltransferase--some functional considerations.
Topics: Acetyltransferases; Animals; Brain; Caudate Nucleus; Cerebellum; Choline; Disease Models, Animal; Ki | 1975 |
Arterial and muscle oxygen tension in experimental models of asthma. Experimental models of asthma.
Topics: Animals; Antibody Formation; Ascaris; Asthma; Catheterization; Choline; Disease Models, Animal; Dogs | 1975 |
Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum.
Topics: Acute Disease; Adipose Tissue; Amylases; Animals; Body Weight; Choline; Disease Models, Animal; Enzy | 1976 |
Repeated antigen challenge induced airway hyperresponsiveness to neurokinin A and vagal non-adrenergic, non-cholinergic (NANC) stimulation in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Antigens; Bronchial Hyperreactivity; Capsaicin; Choline; Disease M | 1992 |
Cholecystokinin protects cholinergic neurons against basal forebrain lesion.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Ch | 1992 |
Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Atropine; Brain Chemistry; | 1991 |
[Biochemical and histopathological studies on a mouse brain ischemic model induced by bilateral carotid artery occlusion: comparison with the carbon monoxide inhalation method and other ischemic or anoxic models].
Topics: Acetylcholine; Adenosine Triphosphate; Administration, Inhalation; Animals; Brain; Brain Ischemia; C | 1991 |
The rat lung organotypic culture: an in vitro model for studying surfactant metabolism abnormalities.
Topics: Animals; Burns; Cells, Cultured; Choline; Disease Models, Animal; Endocytosis; Liposomes; Lung; Pulm | 1991 |
[Parasympathetic origin of atropine- and metacine-induced tachycardia].
Topics: Animals; Atropine; Benzilates; Cats; Choline; Disease Models, Animal; Dogs; Guinea Pigs; Heart; Hear | 1991 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Persistent reduction of indigenous DNA modification (I-compound) levels in liver DNA from male Fischer rats fed choline-devoid diet and in DNA of resulting neoplasms.
Topics: Animals; Autoradiography; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Diet; Diseas | 1990 |
[Study on Alzheimer's disease and the animal disease model--special reference to acetylcholinergic system].
Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Di | 1989 |
Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia.
Topics: Acetylcholine; Animals; Benzoquinones; Brain; Brain Ischemia; Choline; Disease Models, Animal; Energ | 1989 |
Intracortical AF64A: memory impairments and recovery from cholinergic hypofunction.
Topics: Acetylcholine; Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Biological Transport; Cer | 1989 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats.
Topics: Alzheimer Disease; Animals; Aziridines; Behavior, Animal; Choline; Cognition Disorders; Disease Mode | 1989 |
Increased acetylcholine synthesis and release in brains of cats with GM1 gangliosidosis.
Topics: Acetylcholine; Animals; Biological Transport; Brain; Cats; Choline; Choline O-Acetyltransferase; Cor | 1986 |
Menadione-treated synaptosomes as a model for post-ischaemic neuronal damage.
Topics: Acetylcholine; Animals; Brain Ischemia; Calcium; Choline; Disease Models, Animal; Free Radicals; Hyd | 1988 |
Effects of intracerebroventricular injection of AF64A on learning behaviors in rats.
Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Aziridines; Azirines; Choline; Choline O-Ac | 1988 |
Neurochemical effects following AF64A injection into the basal nuclei of rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Aziridines; Azirines; Basal Ganglia; Choline; Chol | 1987 |
A model hypocholinergic syndrome produced by a false choline analog, N-aminodeanol.
Topics: Alzheimer Disease; Animals; Choline; Disease Models, Animal; Rats | 1987 |
Ethylcholine mustard aziridinium ion lesions of the rat cortex result in retrograde degeneration of basal forebrain cholinergic neurons: implications for animal models of neurodegenerative disease.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Basal Ganglia; Cerebral Cortex; Choline; Choline O | 1987 |
Immunohistochemical evidence for degeneration of cholinergic neurons in the forebrain of the rat following injection of AF64A-picrylsulfonate into the dorsal hippocampus.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Choline; Choline O-Acetyltransferase; Cholinergic | 1986 |
Drug metabolism in cirrhosis. Selective changes in cytochrome P-450 isozymes in the choline-deficient rat model.
Topics: Animals; Choline; Choline Deficiency; Cytochrome P-450 Enzyme System; Disease Models, Animal; Isoenz | 1986 |
An attempt to produce cholinergic hypofunction in rat brain using choline mustard aziridinium ion: neurochemical and histological parameters.
Topics: Alzheimer Disease; Animals; Brain; Choline; Disease Models, Animal; Hippocampus; Male; Nerve Degener | 1986 |
Intracerebral injections of AF64A: an animal model of Alzheimer's disease?
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Brain; Choline; Cholinergic Fibers; Disease Models | 1985 |
Changes in the choline acetyltransferase and cholinesterase activities in the levator ani muscle of rats following castration.
Topics: Acetylcholine; Acyltransferases; Animals; Castration; Choline; Cholinesterases; Disease Models, Anim | 1969 |
[Liver tissue enzymes in rats with galactosamine hepatitis during simultaneous administration of choline-orotate].
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Ch | 1973 |
Liquid ventilation in the respiratory distress syndrome.
Topics: Acetates; Animals; Blood Gas Analysis; Carbon Radioisotopes; Choline; Disease Models, Animal; Fetus; | 1974 |
Effect of alcohol on the liver of rats. II. Factors contributing to elevations of plasma transaminase activities and hepatic cell necrosis following a single administration of alcohol in rats.
Topics: Alcohols; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury | 1969 |