choline and Disease Exacerbation studies

Research Excerpts

Excerpt	Relevance	Reference
"Metabolic information obtained from F-fluorocholine PET of patients with glioma may be useful in the prediction of tumor biology and patient prognosis."	9.30	18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas. ( Amo-Salas, M; Barbella, R; Borrás Moreno, JM; García Vicente, AM; Klein Zampaña, CJ; Mollejo Villanueva, M; Pena Pardo, FJ; Pérez-Beteta, J; Pérez-García, VM; Sandoval Valencia, H; Soriano Castrejón, ÁM; Villena Martín, M, 2019)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."	9.13	Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"Humans eating low-choline diets develop fatty liver and liver damage."	8.88	Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. ( Corbin, KD; Zeisel, SH, 2012)
"Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis."	7.83	Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016)
"Characteristic features found at the time of magnetic resonance imaging and magnetic resonance spectroscopy may be helpful for early diagnosis of type II citrullinemia in adult patients who present with hyperammonemic encephalopathy and coma."	7.74	Magnetic resonance spectroscopy in adult-onset citrullinemia: elevated glutamine levels in comatose patients. ( Au, WL; Lim, CC; Wong, YC; Xu, M; Ye, J, 2007)
" The treatment of human breast cancer cells with a nonsteroidal anti-inflammatory agent, indomethacin, reverted the high PC/low GPC pattern to a low PC/high GPC pattern indicative of a less malignant phenotype, supported by decreased invasion."	7.73	Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Jie, C, 2006)
"To clarify the role of cholin- and histaminergic shifts in the onset of circulatory and functional gastric disturbances associated with erosive-ulcer gastroduodenal lesions in myocardial infarction (MI)."	7.73	[Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction]. ( Chernin, VV; Osadchiĭ, VA, 2005)
"We measured free choline in cerebrospinal fluid (CSF) of 78 patients with movement disorders of paediatric onset and various controls as a putative index of central phospholipid metabolism."	7.70	Cerebrospinal fluid free choline in movement disorders of paediatric onset. ( Bergin, A; Brown, CM; Habersang, P; Habersang, R; Hanin, I; Kindel, G; Mack, KJ; Pranzatelli, MR; Rosenbaum, B; Selby, KA; Tate, E; Vasconcellos, M, 1998)
"Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver diseases characterized by steatosis, inflammation, and fibrosis."	5.72	Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. ( Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N, 2022)
"Pioglitazone treatment started at the first signs of fibrosis in both models."	5.51	Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019)
"Esophageal squamous cell carcinoma (ESCC) is a major health threat worldwide."	5.48	Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. ( Hu, C; Ma, W; Wang, S; Xu, G; Yu, JJ; Zhang, EY; Zhang, T; Zhou, L, 2018)
"Metabolic information obtained from F-fluorocholine PET of patients with glioma may be useful in the prediction of tumor biology and patient prognosis."	5.30	18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas. ( Amo-Salas, M; Barbella, R; Borrás Moreno, JM; García Vicente, AM; Klein Zampaña, CJ; Mollejo Villanueva, M; Pena Pardo, FJ; Pérez-Beteta, J; Pérez-García, VM; Sandoval Valencia, H; Soriano Castrejón, ÁM; Villena Martín, M, 2019)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."	5.13	Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy."	5.09	Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001)
"The available literature has proposed mechanisms for an association between gut microbiota and NASH, such as: modification energy homeostasis, lipopolysaccharides (LPS)-endotoxemia, increased endogenous production of ethanol, and alteration in the metabolism of bile acid and choline."	4.98	Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis. ( Cesar, DE; de Castro Ferreira, LEVV; de Faria Ghetti, F; de Oliveira, JM; Moreira, APB; Oliveira, DG, 2018)
"Humans eating low-choline diets develop fatty liver and liver damage."	4.88	Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. ( Corbin, KD; Zeisel, SH, 2012)
"Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle."	3.96	Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020)
"Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volumes correlated with progression-free survival (PFS) and overall survival (OS) in patients with glioblastoma (GBM)."	3.85	Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. ( Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL, 2017)
"Two patients with castrate-resistant prostate cancer and symptomatic skeletal metastases underwent F-fluorocholine PET/CT prior to treatment with Ra-dichloride to reveal additional active lesions in the prostate gland and lymph nodes."	3.85	Soft Tissue Response on 18F-Fluorocholine PET/CT in Metastatic Castrate-Resistant Prostate Cancer Treated With 223Ra-Dichloride: A Possible Abscopal Effect? ( Coel, MN; Kwee, SA; Lim, J, 2017)
"Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis."	3.83	Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016)
"Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy."	3.80	3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. ( Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC, 2014)
"Characteristic features found at the time of magnetic resonance imaging and magnetic resonance spectroscopy may be helpful for early diagnosis of type II citrullinemia in adult patients who present with hyperammonemic encephalopathy and coma."	3.74	Magnetic resonance spectroscopy in adult-onset citrullinemia: elevated glutamine levels in comatose patients. ( Au, WL; Lim, CC; Wong, YC; Xu, M; Ye, J, 2007)
" The treatment of human breast cancer cells with a nonsteroidal anti-inflammatory agent, indomethacin, reverted the high PC/low GPC pattern to a low PC/high GPC pattern indicative of a less malignant phenotype, supported by decreased invasion."	3.73	Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Jie, C, 2006)
" Cerebral MRI shows hypomyelinated white matter and cerebellar atrophy; 1H-MRS of white matter reveals a marked elevation of myo-inositol."	3.73	Leukoencephalopathy with ataxia, hypodontia, and hypomyelination. ( Boltshauser, E; Ebinger, F; Harting, I; Hoffmann, GF; Koch, MJ; Martin, E; Rating, D; Schmitt-Mechelke, T; Uhlenberg, B; Weber, L; Wiegand, G; Wolf, NI; Zschocke, J, 2005)
" Primary central nervous system lymphoma (PCNSL) is a highly aggressive tumor responsive to high-dose methotrexate based regimens."	3.73	Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. ( Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL, 2005)
"To clarify the role of cholin- and histaminergic shifts in the onset of circulatory and functional gastric disturbances associated with erosive-ulcer gastroduodenal lesions in myocardial infarction (MI)."	3.73	[Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction]. ( Chernin, VV; Osadchiĭ, VA, 2005)
" We also did not find a correlation between the amount of Glx and the initial Glasgow Coma Scale score, duration of coma, nor with changes in spectral metabolites, including N-acetyl aspartate, choline, and myoinositol."	3.72	Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. ( Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K, 2004)
"We measured free choline in cerebrospinal fluid (CSF) of 78 patients with movement disorders of paediatric onset and various controls as a putative index of central phospholipid metabolism."	3.70	Cerebrospinal fluid free choline in movement disorders of paediatric onset. ( Bergin, A; Brown, CM; Habersang, P; Habersang, R; Hanin, I; Kindel, G; Mack, KJ; Pranzatelli, MR; Rosenbaum, B; Selby, KA; Tate, E; Vasconcellos, M, 1998)
"Findings consistent with recurrent prostate cancer were noted on FCH PET/CT in 31/50 (62%) patients, with positive findings in 17/18 (94%), and 11/13 (85%), 2/7 (29%), and 1/12 (8%) patients with PSA >4, >2-4, >0."	2.77	Detection of recurrent prostate cancer with 18F-fluorocholine PET/CT in relation to PSA level at the time of imaging. ( Coel, MN; Kwee, SA; Lim, J, 2012)
"Late infantile metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder that causes severe demyelination of the nervous system."	2.75	Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. ( Barton, NW; Fogh, J; Hanson, LG; i Dali, C; Lund, AM; Nair, N, 2010)
"To evaluate the mechanisms underlying disease progression in the early phase of PPMS by measuring metabolite concentrations in normal-appearing white matter (NAWM) and cortical gray matter (CGM) and to assess their relationship with clinical outcomes."	2.71	Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis. ( Chard, DT; Ingle, GT; McLean, MA; Miller, DH; Ramió-Torrentà, L; Sastre-Garriga, J; Thompson, AJ, 2005)
"The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide."	2.66	One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020)
"Prostate cancer is a very heterogeneous disease, and contemporary management is focused on identification and treatment of the prognostically adverse high-risk tumors while minimizing overtreatment of indolent, low-risk tumors."	2.61	Multimodality Imaging of Prostate Cancer. ( Burger, IA; Ghafoor, S; Vargas, AH, 2019)
"Disease progression was investigated at 4 time points, from 9 to 18 months of age, and in 4 regions: cortex, hippocampus, striatum, and thalamus."	1.72	Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. ( López-Gil, X; Muñoz-Moreno, E; Simões, RV; Soria, G; Tudela, R, 2022)
"NAFLD is typically associated with obesity and diabetes, however it also develops in lean individuals without metabolic syndrome."	1.72	Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice. ( Farazi, PA; Fisher, KW; Hymel, E; Vlock, E, 2022)
"Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver diseases characterized by steatosis, inflammation, and fibrosis."	1.72	Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. ( Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N, 2022)
"Meningiomas are common brain tumours that are usually defined by benign clinical course."	1.62	Metabolic alterations in meningioma reflect the clinical course. ( Beck, J; Daka, K; Delev, D; Grauvogel, J; Heiland, DH; Krüger, MT; Masalha, W; Pompe, N; Schnell, O; Weber, S; Woerner, J, 2021)
"Pioglitazone treatment started at the first signs of fibrosis in both models."	1.51	Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019)
"Esophageal squamous cell carcinoma (ESCC) is a major health threat worldwide."	1.48	Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. ( Hu, C; Ma, W; Wang, S; Xu, G; Yu, JJ; Zhang, EY; Zhang, T; Zhou, L, 2018)
"Choline was significantly elevated in FEP compared to HC."	1.48	Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients. ( Gonzales, SS; Kraguljac, NV; Lahti, AC; Morgan, CJ; Sivaraman, S; White, DM, 2018)
"For successful treatment for nonalcoholic steatohepatitis (NASH), it may be important to treat the individual causative factors."	1.46	Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. ( Feng, GG; Goto, H; Hayashi, K; Hirooka, Y; Honda, T; Ishigami, M; Ishikawa, T; Ishizu, Y; Katano, Y; Kitaura, Y; Kohama, T; Kuzuya, T; Lingyun, M; Luo, F; Nakano, I; Shimomura, Y, 2017)
"A new entity of patients with recurrent prostate cancer limited to a small number of active metastatic lesions is having growing interest: the oligometastatic patients."	1.43	[(18)F]Choline PET/CT and stereotactic body radiotherapy on treatment decision making of oligometastatic prostate cancer patients: preliminary results. ( Cocuzza, P; Coraggio, G; Derosa, L; Erba, PA; Fabrini, MG; Ferrazza, P; Galli, L; Greco, C; Mannelli, L; Matteucci, F; Monzani, F; Ortori, S; Panichi, M; Pasqualetti, F; Pasqualetti, G; Ricci, S; Sainato, A; Sollini, M, 2016)
"The major outcome measure was disease progression at PET2."	1.40	Prostate-specific antigen kinetics parameters are predictive of positron emission tomography features worsening in patients with biochemical relapse after prostate cancer treatment with radical intent: Results from a longitudinal cohort study. ( Bartolini, M; Cai, T; Carini, M; Ceroti, M; Detti, B; Gacci, M; Giannì, G; Livi, L; Minervini, A; Pupi, A; Saieva, C; Siena, G; Torshizi, MF, 2014)
"We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD)."	1.40	Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. ( Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M, 2014)
"Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet."	1.40	Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. ( Guo, J; Li, J; Li, X; Liu, Y; Wang, L; Wu, T; Yang, Y; Yuan, F; Zhang, Q; Zheng, L, 2014)
"Spinocerebellar ataxia type 1 (SCA1) is a hereditary, progressive and fatal movement disorder that primarily affects the cerebellum."	1.39	Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1. ( Brent Clark, H; Eberly, LE; Emir, UE; Öz, G; Vollmers, ML, 2013)
"11C-Choline PET was positive in 124/185 cases (65%) (in 22/61 (36%) after RP, 102/124 (82%) after EBRT)."	1.39	Impact of total PSA, PSA doubling time and PSA velocity on detection rates of 11C-Choline positron emission tomography in recurrent prostate cancer. ( Breeuwsma, AJ; de Jong, IJ; Dierckx, RA; Leliveld, AM; Pruim, J; Rybalov, M, 2013)
"Neuromyelitis optica was diagnosed."	1.39	Unusual manifestations of pediatric neuromyelitis optica. ( Kiresi, D; Yavuz, H, 2013)
"Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world."	1.38	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. ( Camporez, JP; Eisenbarth, SC; Elinav, E; Flavell, RA; Gordon, JI; Hao, L; Henao-Mejia, J; Hoffman, HM; Jin, C; Jurczak, MJ; Kau, AL; Mehal, WZ; Shulman, GI; Strowig, T; Thaiss, CA, 2012)
"This is especially true for prostate cancer, a disease that is characterized by increasing DNA methylation changes with increasing grade of the cancer."	1.38	Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence. ( Carducci, MA; Herman, JG; Shabbeer, S; Simons, BW; Williams, SA, 2012)
"NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in Western populations."	1.38	Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. ( Chaba, T; Jacobs, RL; Ling, J; Vance, DE; Zhu, LF, 2012)
"Seventy-four patients with breast cancer (mean age 54 years) who underwent (11)C-choline and 2-[(18)F]fluoro-2-deoxy-d-glucose ((18)F-FDG) PET/CT prior to surgery on the same day were enrolled in the present study."	1.38	Comparative study of the value of dual tracer PET/CT in evaluating breast cancer. ( Akashi-Tanaka, S; Daisaki, H; Kano, D; Kinoshita, T; Macapinlac, HA; Murano, T; Tateishi, U; Terauchi, T; Tsuda, H, 2012)
"Neurological involvement in X-linked mucopolysaccharidosis type II (Hunter syndrome) is indicative of more severe disease, but is not attenuated by current enzyme replacement therapy which does not significantly penetrate the blood-brain barrier."	1.36	Quantitative in vivo brain magnetic resonance spectroscopic monitoring of neurological involvement in mucopolysaccharidosis type II (Hunter Syndrome). ( Davies, NP; Davison, JE; Gissen, P; Hendriksz, CJ; Peet, AC; Sun, Y, 2010)
"Fourteen patients with juvenile absence epilepsy with typical absence seizures and 10 healthy volunteer controls were included in this study."	1.36	A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages. ( Erdinc, O; Gumustas, OG; Kabay, SC; Karaman, HO; Ozden, H, 2010)
"Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress."	1.36	Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. ( Ashford, ML; Chowdhry, S; Dillon, JF; Dinkova-Kostova, AT; Hayes, JD; Meakin, PJ; Nazmy, MH; Tsujita, T; Walsh, SV, 2010)
"He was diagnosed as having familial hemophagocytic lymphohistiocytosis and treated with the HLH 2004 protocol."	1.35	Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis. ( Gibikote, S; Kumar, S; Moses, PD; Puliyel, MM; Rose, W, 2009)
"Previous studies have shown that COPD adversely affects distant organs and body systems, including the brain."	1.35	Modeling the impact of COPD on the brain. ( Anzai, Y; Aylward, E; Borson, S; Fields, J; Friedman, S; Mahurin, R; Richards, T; Scanlan, J; Yeh, S; Yukawa, M; Zuhr, E, 2008)
"Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion."	1.35	Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. ( Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH, 2008)
"Prion diseases are fatal chronic neurodegenerative diseases."	1.34	MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. ( Anthony, DC; Blamire, AM; Broom, KA; Griffin, JL; Lowe, JP; Perry, VH; Scott, H; Sibson, NR; Styles, P, 2007)
"When pioglitazone treatment was initiated after five weeks of CCl4, no antifibrotic effect was observed."	1.33	Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats. ( Horsmans, Y; Leclercq, IA; Sempoux, C; Stärkel, P, 2006)
"Nonalcoholic steatohepatitis (NASH) may cause fibrosis, cirrhosis, and hepatocellular carcinoma (HCC); however, the exact mechanism of disease progression is not fully understood."	1.33	Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. ( Akahane, T; Asada, K; Fukui, H; Ikenaka, Y; Kaji, K; Kitade, M; Kojima, H; Namisaki, T; Noguchi, R; Tsujimoto, T; Uemura, M; Yamazaki, M; Yanase, K; Yoshii, J; Yoshiji, H, 2006)
"11C-choline uptake was found in all primary transitional cell carcinomas, with a maximum standardized uptake value of 7."	1.33	Contribution of 11C-choline positron emission tomography/computerized tomography to preoperative staging of advanced transitional cell carcinoma. ( Chisin, R; Freedman, N; Gofrit, ON; Katz, R; Klein, M; Libson, E; Mishani, E; Orevi, M; Pode, D; Shapiro, A, 2006)
"A slowly progressive sensory ataxia is a typical feature in this new leukodystrophy."	1.32	Five new cases of a recently described leukoencephalopathy with high brain lactate. ( Aärimaa, T; Autti, T; Häkkinen, AM; Koillinen, H; Kuusi, T; Linnankivi, T; Lönnqvist, T; Lundbom, N; Pihko, H; Sainio, K; Valanne, L, 2004)
"Pretreatment with pargyline attenuated the MPTP-induced clinical signs, MRI and MRS changes, and the histopathological and immunoreactivity alterations."	1.32	Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. ( Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA, 2003)
"In these patients spasticity began in the legs and progressed slowly and steadily."	1.32	Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes? ( Butman, JA; Floeter, MK; Pagan, F; Statland, J; Zhai, P, 2003)
"The fulminating form of subacute sclerosing panencephalitis is an extremely rare condition."	1.32	Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings. ( Alkan, A; Aslan, M; Kutlu, R; Sarac, K; Sigirci, A; Yakinci, C, 2004)
"The diagnosis of gliomatosis cerebri with MR imaging is known to be difficult."	1.31	MR spectroscopy in gliomatosis cerebri. ( Bendszus, M; Burger, R; Klein, R; Schichor, C; Solymosi, L; Tonn, JC; Warmuth-Metz, M, 2000)
"They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures."	1.31	Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency. ( de Koning, TJ; Jaeken, J; Pineda, M; Poll-The, BT; van der Knaap, MS; Van Maldergem, L, 2000)
"The metabolic disturbances indicate disease progression but are less pronounced than in older patients with hemimegalencephaly."	1.30	Proton magnetic resonance spectroscopy of linear nevus sebaceus syndrome. ( Christen, HJ; Frahm, J; Hanefeld, FA; Kruse, B; Pouwels, PJ, 1998)

Research

Studies (153)

Authors

Clinical Trials (16)

Trial Overview

Trial Outcomes

Metabolically Active Tumor Volume (MATV) Response

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.65)	18.7374
1990's	7 (4.58)	18.2507
2000's	56 (36.60)	29.6817
2010's	73 (47.71)	24.3611
2020's	16 (10.46)	2.80

Authors	Studies
Lee, N	1
Heo, YJ	1
Choi, SE	1
Jeon, JY	1
Han, SJ	1
Kim, DJ	1
Kang, Y	1
Lee, KW	1
Kim, HJ	2
Hymel, E	1
Vlock, E	1
Fisher, KW	1
Farazi, PA	1
Alamiri, J	1
Britton, CJ	1
Ahmed, ME	1
Andrews, JR	1
Higa, JL	1
Dundar, A	1
Karnes, RJ	1
Kwon, E	1
Lowe, VJ	1
Kendi, AT	1
Bold, MS	1
Pagliaro, LC	1
Muñoz-Moreno, E	1
Simões, RV	1
Tudela, R	1
López-Gil, X	1
Soria, G	1
Sidibe, I	1
Tensaouti, F	1
Gilhodes, J	1
Cabarrou, B	1
Filleron, T	1
Desmoulin, F	1
Ken, S	1
Noël, G	1
Truc, G	1
Sunyach, MP	1
Charissoux, M	1
Magné, N	1
Lotterie, JA	1
Roques, M	1
Péran, P	1
Cohen-Jonathan Moyal, E	1
Laprie, A	2
Houske, EA	1
Glimm, MG	1
Bergstrom, AR	1
Slipher, SK	1
Welhaven, HD	1
Greenwood, MC	1
Linse, GM	1
June, RK	1
Yu, ASL	1
Wallace, DP	1
Hahn, AK	1
Ghafoor, S	1
Burger, IA	1
Vargas, AH	1
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Krüger, MT	1
Schnell, O	1
Beck, J	1
Heiland, DH	1
Grauvogel, J	1
Shiga, Y	1
Nezu, T	1
Nakamori, M	1
Hosomi, N	1
Akiyama, Y	1
Tachiyama, K	1
Kamimura, T	1
Kinoshita, N	1
Hayashi, Y	1
Matsushima, H	1
Imamura, E	1
Aoki, S	1
Ueno, H	1
Ohshita, T	1
Wakabayashi, S	1
Yamasaki, F	1
Awai, K	1
Maruyama, H	1
Zhu, Y	2
Zhao, H	1
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Kwee, SA	3
Lim, J	2
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de Castro Ferreira, LEVV	1
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Ma, W	1
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Zhou, L	1
Hu, C	1
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Kraguljac, NV	1
White, DM	1
Morgan, CJ	1
Gonzales, SS	1
Lahti, AC	1
Li, S	1
Ghoshal, S	1
Sojoodi, M	1
Arora, G	1
Masia, R	1
Erstad, DJ	1
Lanuti, M	1
Hoshida, Y	1
Baumert, TF	1
Tanabe, KK	1
Fuchs, BC	1
Liu, W	1
Ye, C	1
Cheng, Q	1
Zhang, X	1
Yao, L	1
Li, Q	1
Huang, J	1
Liu, Y	2
Zou, Z	1
Wang, H	1
Yan, J	1
Wang, C	1
Ai, D	1
Mujukian, A	1
Kay, M	1
Wortmann, SB	1
Mayr, JA	1
Sharma, K	1
García Vicente, AM	1
Pérez-Beteta, J	1
Amo-Salas, M	1
Pena Pardo, FJ	1
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Sandoval Valencia, H	1
Mollejo Villanueva, M	1
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Klein Zampaña, CJ	1
Borrás Moreno, JM	1
Soriano Castrejón, ÁM	1
Pérez-García, VM	1
Fedele, TA	1
Galdos-Riveros, AC	1
Jose de Farias e Melo, H	1
Magalhães, A	1
Maria, DA	1
Kantarci, K	3
Shimozono, R	2
Asaoka, Y	1
Yoshizawa, Y	1
Aoki, T	1
Noda, H	1
Yamada, M	1
Kaino, M	1
Mochizuki, H	1
Gongvatana, A	1
Harezlak, J	1
Buchthal, S	1
Daar, E	1
Schifitto, G	1
Campbell, T	1
Taylor, M	1
Singer, E	1
Algers, J	1
Zhong, J	1
Brown, M	1
McMahon, D	1
So, YT	1
Mi, D	1
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Yiannoutsos, C	1
Cohen, RA	1
Navia, B	1
Stromillo, ML	1
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Battaglini, M	1
Hakiki, B	1
Malentacchi, G	1
Santangelo, M	1
Gasperini, C	1
Bartolozzi, ML	1
Portaccio, E	1
Amato, MP	1
De Stefano, N	2
Emir, UE	1
Brent Clark, H	1
Vollmers, ML	1
Eberly, LE	1
Öz, G	1
Targosz-Gajniak, MG	1
Siuda, JS	1
Wicher, MM	1
Banasik, TJ	1
Bujak, MA	1
Augusciak-Duma, AM	1
Opala, G	1
Bruggers, CS	1
Moore, K	1
Gacci, M	1
Cai, T	1
Siena, G	1
Minervini, A	1
Torshizi, MF	1
Bartolini, M	1
Giannì, G	1
Saieva, C	1
Ceroti, M	1
Detti, B	1
Livi, L	1
Pupi, A	1
Carini, M	1
Ritchie, CW	1
Bajwa, J	1
Coleman, G	1
Hope, K	1
Jones, RW	1
Lawton, M	1
Marven, M	1
Passmore, P	1
Waragai, M	1
Hata, S	1
Suzuki, T	2
Ishii, R	1
Fujii, C	1
Tokuda, T	1
Arai, H	1
Ohrui, T	1
Higuchi, S	1
Yoshida, M	1
Igarashi, K	1
Moriya, M	1
Iwai, N	1
Uemura, K	1
Muruganandham, M	1
Clerkin, PP	1
Smith, BJ	1
Anderson, CM	1
Morris, A	1
Capizzano, AA	1
Magnotta, V	1
McGuire, SM	1
Smith, MC	1
Bayouth, JE	1
Buatti, JM	1
Papalia, R	1
Jereczek-Fossa, BA	1
Gallucci, M	1
Maini, CL	1
Yang, Y	1
Zheng, L	1
Wu, T	1
Li, J	1
Zhang, Q	1
Li, X	2
Yuan, F	1
Wang, L	1
Guo, J	1
Nishimura, K	1
Akiyama, H	1
Funamoto, S	1
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Bhushan, S	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Glutamate, Brain Connectivity and Duration of Untreated Psychosis[NCT02034253]		134 participants (Actual)	Observational	2014-01-31	Completed
Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477]	Phase 1	150 participants (Anticipated)	Interventional	2016-09-30	Enrolling by invitation
Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770]		300 participants (Anticipated)	Interventional	2019-12-01	Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development)
Chemotherapy Response Monitoring With 18F-choline PET/CT in Hormone Refractory Prostate Cancer[NCT00928252]	Phase 1/Phase 2	25 participants (Actual)	Interventional	2009-06-30	Completed
Measurement of Anti-Androgen Response Using Fluorine-18 Fluorocholine PET/CT in Androgen-Insensitive Prostate Cancer[NCT00928174]	Phase 1/Phase 2	27 participants (Actual)	Interventional	2009-06-30	Completed
Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206]		12 participants (Anticipated)	Observational	2020-12-31	Not yet recruiting
A Phase I/II, Open Labeled, Monocentric Study of Direct Intracranial Administration of a Replication Deficient Adeno-associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human ARSA cDNA to Children With Metachromatic Leukodystrophy.[NCT01801709]	Phase 1/Phase 2	5 participants (Anticipated)	Interventional	2014-06-30	Active, not recruiting
Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168]		60 participants (Anticipated)	Interventional	2020-04-01	Recruiting
The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD[NCT05200156]		100 participants (Anticipated)	Interventional	2022-02-01	Recruiting
The Role of Microbiome Reprogramming on Liver Fat Accumulation[NCT03914495]		57 participants (Actual)	Interventional	2019-05-21	Terminated (stopped due to PI carefully considered multiple factors and decided to close study to any further enrollment.)
Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan[NCT04671186]		47 participants (Actual)	Interventional	2020-09-07	Completed
Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery[NCT03391401]		204 participants (Actual)	Observational	2018-03-01	Completed
Sjogren-Larsson Syndrome: A Longitudinal Study of Natural History, Clinical Variation and Evaluation of Biochemical Markers[NCT01971957]		20 participants (Actual)	Observational [Patient Registry]	2013-04-01	Completed
An Open-label, Non-randomized, Phase I/II Study of Autologous Bone Marrow-Derived Mononuclear Stem Cells (BM-MNC) and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS[NCT02587806]	Phase 1/Phase 2	69 participants (Anticipated)	Interventional	2015-02-28	Recruiting
An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitti[NCT02587715]	Phase 1/Phase 2	69 participants (Anticipated)	Interventional	2015-02-28	Recruiting
An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitti[NCT02418325]	Phase 1/Phase 2	69 participants (Anticipated)	Interventional	2015-02-28	Terminated (stopped due to Lack of funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of patients achieving 30% or greater reduction in MATV measured on 18F-fluorocholine PET/CT (NCT00928252)
Timeframe: 21 to 98 days

Proportional Hazards Regression Analysis of Time to PSA Progression

Intervention	Participants (Count of Participants)
Received 18F-fluorocholine PET/CT	20

PSA levels measured from the start of treatment over the period of follow-up were recorded. Time to PSA progression was calculated as the number of days from the start of treatment to the date of the first PSA test result that represented a 30% or greater increase from the PSA nadir, confirmed on the basis of repeated PSA measurements. For proportional hazards regression analysis, the percentage change in PSA level within 15 wk of starting treatment was calculated, using a 50% or greater decrease in PSA level as a predefined definition of PSA re- sponse based on Prostate Cancer Working Group guidelines. (NCT00928252)
Timeframe: Up to 15 week post-chemotherapy

Time to PSA Progression

Intervention	Hazard Ratio (Number)
Positive Metabolically Active Tumor Response	0.246

Time to PSA Progression between patients exhibiting MATV reduction greater or equal to 30% vs. MATV reduction less than 30%. (NCT00928252)
Timeframe: 2 years

Prostate Specific Antigen (PSA) Outcome Correspondence to Imaging Results With Fluorine-18 Fluorocholine PET/CT

Intervention	days (Mean)
	MATV reduction > or = 30%	MATV reduction < 30%
Received 18F-fluorocholine PET/CT	194	116

The percentage of patients within a given prostate specific antigen range found to have at least one abnormal lesion demonstrating increased fluorine-18 fluorocholine uptake on positron emission tomography (PET) imaging consistent with the clinical diagnosis of metastatic or recurrent prostate cancer. (NCT00928174)
Timeframe: Concurrent with PET Procedure

Intervention	%PET-positive cases in a given PSA range (Number)
	PSA > 4 ng/mL (19 cases)	PSA 2-4 ng/mL (2 cases)	PSA > 0.5 - 2 ng/mL (1 cases)	PSA <= 0.5 ng/mL (0 cases)
Single Arm	100	100	100	0

Article	Year
Multimodality Imaging of Prostate Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019, Volume: 60, Issue:10 Topics: Aged; Antigens, Surface; Carboxylic Acids; Choline; Cyclobutanes; Disease Progression; Fluorodeoxygl	2019
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. Lifestyle genomics, 2020, Volume: 13, Issue:2 Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi	2020
Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease Progression. Critical reviews in oncogenesis, 2020, Volume: 25, Issue:1 Topics: Animals; Choline; Disease Progression; Dysbiosis; Fecal Microbiota Transplantation; Gastrointestinal	2020
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis. European journal of nutrition, 2018, Volume: 57, Issue:3 Topics: Animals; Bile Acids and Salts; Choline; Diet; Disease Progression; Dysbiosis; Endotoxemia; Energy In	2018
Choline-related-inherited metabolic diseases-A mini review. Journal of inherited metabolic disease, 2019, Volume: 42, Issue:2 Topics: Animals; Choline; Choline Deficiency; Dietary Supplements; Disease Progression; Humans; Liver; Metab	2019
Cholinesterase inhibitors as Alzheimer's therapeutics (Review). Molecular medicine reports, 2019, Volume: 20, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; Cognition; Dis	2019
Proton MRS in mild cognitive impairment. Journal of magnetic resonance imaging : JMRI, 2013, Volume: 37, Issue:4 Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati	2013
[Diagnostic relevance of choline-PET / CT in patients with prostate cancer]. Aktuelle Urologie, 2012, Volume: 43, Issue:1 Topics: Bone Neoplasms; Carbon Radioisotopes; Choline; Disease Progression; Fluorine Radioisotopes; Humans;	2012
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Current opinion in gastroenterology, 2012, Volume: 28, Issue:2 Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic	2012
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Current opinion in gastroenterology, 2012, Volume: 28, Issue:2 Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic	2012
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Current opinion in gastroenterology, 2012, Volume: 28, Issue:2 Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic	2012
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Current opinion in gastroenterology, 2012, Volume: 28, Issue:2 Topics: Animals; Choline; Disease Progression; Fatty Liver; Humans; Liver; Metabolic Syndrome; Non-alcoholic	2012
[Corpus callosum tumor as the presenting symptom of neurofibromatosis type 1 in a patient and literature review]. Revista de neurologia, 2012, Nov-01, Volume: 55, Issue:9 Topics: Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child, Preschool; Choline; Corpus Callo	2012
In vivo proton magnetic resonance spectroscopy of breast lesions: an update. Breast cancer research and treatment, 2007, Volume: 104, Issue:3 Topics: Breast; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Choline; Disease Progression; False	2007
Proton MR spectroscopy in multiple sclerosis. Neuroimaging clinics of North America, 2000, Volume: 10, Issue:4 Topics: Aspartic Acid; Brain; Choline; Creatine; Disability Evaluation; Disease Progression; Energy Metaboli	2000

Article	Year
Pseudoprogression in GBM versus true progression in patients with glioblastoma: A multiapproach analysis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023, Volume: 181 Topics: Brain Neoplasms; Choline; Disease Progression; Glioblastoma; Humans; Magnetic Resonance Imaging; Neo	2023
Efficacy of docosahexaenoic acid-choline-vitamin E in paediatric NASH: a randomized controlled clinical trial. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:9 Topics: Adolescent; Biomarkers; Biopsy; Child; Child Nutritional Physiological Phenomena; Choline; Combined	2017
18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas. Clinical nuclear medicine, 2019, Volume: 44, Issue:10 Topics: Choline; Chromosome Deletion; Disease Progression; Female; Glioma; Humans; Isocitrate Dehydrogenase;	2019
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. Journal of neuro-oncology, 2008, Volume: 90, Issue:1 Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis	2008
Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis. Archives italiennes de biologie, 2009, Volume: 147, Issue:3 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Choline; Creatinine; Diffusio	2009
Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. Neurology, 2010, Nov-23, Volume: 75, Issue:21 Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Choline; Cognition; Creatine; Disease Progressio	2010
Detection of recurrent prostate cancer with 18F-fluorocholine PET/CT in relation to PSA level at the time of imaging. Annals of nuclear medicine, 2012, Volume: 26, Issue:6 Topics: Aged; Aged, 80 and over; Choline; Disease Progression; Humans; Male; Middle Aged; Multimodal Imaging	2012
Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis. Archives of neurology, 2005, Volume: 62, Issue:4 Topics: Adult; Age of Onset; Aged; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Choline	2005
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study. Dementia and geriatric cognitive disorders, 2008, Volume: 25, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disord	2008
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. Stroke, 2001, Dec-01, Volume: 32, Issue:12 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female;	2001

Article	Year
Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. Biochemical and biophysical research communications, 2022, 01-15, Volume: 588 Topics: Amino Acids; Animals; Benzhydryl Compounds; Choline; Cytokines; Diet, High-Fat; Disease Models, Anim	2022
Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice. PloS one, 2022, Volume: 17, Issue:8 Topics: Animals; Carcinoma, Hepatocellular; Cholesterol; Choline; Diet, High-Fat; Disease Models, Animal; Di	2022
Radiographic paradoxical response in metastatic castrate-resistant prostate cancer (mCRPC) managed with new generation anti-androgens: a retrospective analysis. The Prostate, 2022, Volume: 82, Issue:16 Topics: Androgen Antagonists; Choline; Disease Progression; Docetaxel; Humans; Male; Positron Emission Tomog	2022
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Scientific reports, 2022, 10-10, Volume: 12, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Choline; Creatine; Disease Models, Animal; Disease Progression; G	2022
Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease. American journal of physiology. Renal physiology, 2023, 06-01, Volume: 324, Issue:6 Topics: Amino Acids; Androgens; Biomarkers; Choline; Disease Progression; Fatty Acids; Humans; Metabolic Net	2023
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T. Scientific reports, 2019, 11-26, Volume: 9, Issue:1 Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression;	2019
Quantitative metabolic biomarker analysis of mild cognitive impairment in eastern U.P. and Bihar population. Journal of pharmaceutical and biomedical analysis, 2020, Feb-20, Volume: 180 Topics: Aged; Alanine; Biomarkers; Blood Glucose; Blood Specimen Collection; Choline; Cognitive Dysfunction;	2020
Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis. Cell reports, 2020, 02-25, Volume: 30, Issue:8 Topics: Amyotrophic Lateral Sclerosis; Animals; Anoctamins; Biomarkers; Chloride Channels; Choline; Disease	2020
18F-choline PET/CT driven salvage radiotherapy in prostate cancer patients: up-date analysis with 5-year median follow-up. La Radiologia medica, 2020, Volume: 125, Issue:7 Topics: Aged; Aged, 80 and over; Choline; Disease Progression; Follow-Up Studies; Humans; Male; Middle Aged;	2020
COVID-19 pneumonia: increased choline uptake with 18F-choline PET/CT. European journal of nuclear medicine and molecular imaging, 2020, Volume: 47, Issue:10 Topics: Choline; Coronavirus Infections; COVID-19; Disease Progression; Humans; Inflammation; Lung; Macropha	2020
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. Nutrition research (New York, N.Y.), 2020, Volume: 82 Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements;	2020
Metabolic alterations in meningioma reflect the clinical course. BMC cancer, 2021, Mar-01, Volume: 21, Issue:1 Topics: Aged; Algorithms; Biomarkers, Tumor; Choline; Cluster Analysis; Disease Progression; Female; Glycine	2021
Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:6 Topics: Aged; Aged, 80 and over; Basal Ganglia Cerebrovascular Disease; Biomarkers; Brain Infarction; Cholin	2021
Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis. Cellular and molecular gastroenterology and hepatology, 2021, Volume: 12, Issue:2 Topics: Animals; Caspases, Initiator; Choline; Diet; Disease Progression; Hepatocytes; Inflammation; Lipopol	2021
Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging. Human brain mapping, 2017, Volume: 38, Issue:8 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Cross-Sectional Studies; Disease Progression; Female	2017
ATP1A3 mutant patient with alternating hemiplegia of childhood and brain spectroscopic abnormalities. Journal of the neurological sciences, 2017, 08-15, Volume: 379 Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Disease Progression; Hemiplegia; Humans; Magn	2017
Soft Tissue Response on 18F-Fluorocholine PET/CT in Metastatic Castrate-Resistant Prostate Cancer Treated With 223Ra-Dichloride: A Possible Abscopal Effect? Clinical nuclear medicine, 2017, Volume: 42, Issue:11 Topics: Aged, 80 and over; Choline; Disease Progression; Humans; Male; Neoplasm Metastasis; Positron Emissio	2017
Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. Journal of pharmaceutical and biomedical analysis, 2018, Jun-05, Volume: 155 Topics: Amino Acids; Biomarkers, Tumor; Carcinoma, Squamous Cell; Choline; Choline Kinase; Chromatography, H	2018
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients. Psychiatry research. Neuroimaging, 2018, 11-30, Volume: 281 Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Diseas	2018
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019, Volume: 23, Issue:1 Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-	2019
Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. Cellular and molecular gastroenterology and hepatology, 2019, Volume: 7, Issue:1 Topics: Animals; Apoptosis; Calcium; Cholesterol; Choline; Diet; Disease Progression; Dynamins; Feeding Beha	2019
Indeterminate single bone lesion on multimodality imaging of prostate cancer. BMJ case reports, 2019, Jan-07, Volume: 12, Issue:1 Topics: Adenocarcinoma; Aged; Bone Neoplasms; Choline; Diagnosis, Differential; Diphosphonates; Disease Prog	2019
Prognostic relationship of metabolic profile obtained of melanoma B16F10. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:2 Topics: Animals; Apoptosis; Biomarkers, Tumor; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation;	2013
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Molecular pharmacology, 2013, Volume: 84, Issue:1 Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Antioxidants; Binding Sites; Cell Line; Choline; Die	2013
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy. Journal of neurovirology, 2013, Volume: 19, Issue:3 Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid;	2013
Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome. Neurology, 2013, Jun-04, Volume: 80, Issue:23 Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic	2013
Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1. Journal of neurochemistry, 2013, Volume: 127, Issue:5 Topics: Animals; Ataxin-1; Ataxins; Cerebellum; Choline; Disease Models, Animal; Disease Progression; Gene K	2013
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. Journal of the neurological sciences, 2013, Dec-15, Volume: 335, Issue:1-2 Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D	2013
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. Journal of the neurological sciences, 2013, Dec-15, Volume: 335, Issue:1-2 Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D	2013
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. Journal of the neurological sciences, 2013, Dec-15, Volume: 335, Issue:1-2 Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D	2013
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. Journal of the neurological sciences, 2013, Dec-15, Volume: 335, Issue:1-2 Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D	2013
Magnetic resonance imaging spectroscopy in pediatric atypical teratoid rhabdoid tumors of the brain. Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:6 Topics: Brain; Brain Neoplasms; Child, Preschool; Choline; Chromosomal Proteins, Non-Histone; Creatine; Diag	2014
Prostate-specific antigen kinetics parameters are predictive of positron emission tomography features worsening in patients with biochemical relapse after prostate cancer treatment with radical intent: Results from a longitudinal cohort study. Scandinavian journal of urology, 2014, Volume: 48, Issue:3 Topics: Aged; Choline; Cohort Studies; Disease Progression; Humans; Kallikreins; Longitudinal Studies; Male;	2014
Souvenaid®: a new approach to management of early Alzheimer's disease. The journal of nutrition, health & aging, 2014, Volume: 18, Issue:3 Topics: Alzheimer Disease; Choline; Cholinesterase Inhibitors; Disease Progression; Docosahexaenoic Acids; D	2014
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; De	2014
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. International journal of radiation oncology, biology, physics, 2014, Sep-01, Volume: 90, Issue:1 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; C	2014
¹⁸F-choline positron emission tomography/computed tomography-driven high-dose salvage radiation therapy in patients with biochemical progression after radical prostatectomy: feasibility study in 60 patients. International journal of radiation oncology, biology, physics, 2014, Oct-01, Volume: 90, Issue:2 Topics: Aged; Aged, 80 and over; Choline; Disease Progression; Feasibility Studies; Fluorine Radioisotopes;	2014
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. Molecular bioSystems, 2014, Volume: 10, Issue:12 Topics: Animals; Atherosclerosis; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Choline; Diet, High-Fat; D	2014
Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2015, Volume: 35, Issue:6 Topics: Animals; Cell Cycle; Choline; Choline Deficiency; Disease Models, Animal; Disease Progression; Food,	2015
Prostate-specific antigen and radiolabelled choline PET/CT for the assessment of response to therapy: synergy or conflicting? European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:1 Topics: Biological Transport; Carbon Radioisotopes; Choline; Disease Progression; Humans; Male; Multimodal I	2016
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting. Parkinsonism & related disorders, 2016, Volume: 22 Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf	2016
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. Circulation. Heart failure, 2016, Volume: 9, Issue:1 Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi	2016
[(18)F]Choline PET/CT and stereotactic body radiotherapy on treatment decision making of oligometastatic prostate cancer patients: preliminary results. Radiation oncology (London, England), 2016, Jan-22, Volume: 11 Topics: Aged; Choline; Contrast Media; Decision Making; Decision Support Techniques; Diffusion Magnetic Reso	2016
PET/CT and MRI directed extended salvage radiotherapy in recurrent prostate cancer with lymph node metastases. Advances in medical sciences, 2016, Volume: 61, Issue:2 Topics: Aged; Choline; Cohort Studies; Contrast Media; Disease Progression; Follow-Up Studies; Humans; Lymph	2016
Prediction of PSA Progression in Castration-Resistant Prostate Cancer Based on Treatment-Associated Change in Tumor Burden Quantified by 18F-Fluorocholine PET/CT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:7 Topics: Aged; Androgen Antagonists; Antineoplastic Agents; Cancer Vaccines; Choline; Combined Modality Thera	2016
Prediction of PSA Progression in Castration-Resistant Prostate Cancer Based on Treatment-Associated Change in Tumor Burden Quantified by 18F-Fluorocholine PET/CT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:7 Topics: Aged; Androgen Antagonists; Antineoplastic Agents; Cancer Vaccines; Choline; Combined Modality Thera	2016
Prediction of PSA Progression in Castration-Resistant Prostate Cancer Based on Treatment-Associated Change in Tumor Burden Quantified by 18F-Fluorocholine PET/CT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:7 Topics: Aged; Androgen Antagonists; Antineoplastic Agents; Cancer Vaccines; Choline; Combined Modality Thera	2016
Prediction of PSA Progression in Castration-Resistant Prostate Cancer Based on Treatment-Associated Change in Tumor Burden Quantified by 18F-Fluorocholine PET/CT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:7 Topics: Aged; Androgen Antagonists; Antineoplastic Agents; Cancer Vaccines; Choline; Combined Modality Thera	2016
Normalisation of brain spectroscopy findings in Niemann-Pick disease type C patients treated with miglustat. Journal of neurology, 2016, Volume: 263, Issue:5 Topics: 1-Deoxynojirimycin; Adolescent; Adult; Aspartic Acid; Brain; Choline; Disability Evaluation; Disease	2016
18F-fluorocholine versus 18F-fluorodeoxyglucose for PET/CT imaging in patients with suspected relapsing or progressive multiple myeloma: a pilot study. European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:11 Topics: Aged; Aged, 80 and over; Choline; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Male;	2016
MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease. Toxicology letters, 2016, Sep-06, Volume: 258 Topics: Animals; Biomarkers; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal;	2016
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies. Neuroradiology, 2016, Volume: 58, Issue:10 Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child,	2016
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. Radiology, 2017, Volume: 284, Issue:1 Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor I	2017
Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Metabolism: clinical and experimental, 2017, Volume: 69 Topics: Adipose Tissue; Amino Acids, Branched-Chain; Animals; Cholesterol; Choline; Citrate (si)-Synthase; D	2017
Modeling the impact of COPD on the brain. International journal of chronic obstructive pulmonary disease, 2008, Volume: 3, Issue:3 Topics: Affect; Aged; Brain; Brain Diseases; Choline; Cognition; Cognition Disorders; Disease Progression; F	2008
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. Acta radiologica (Stockholm, Sweden : 1987), 2008, Volume: 49, Issue:10 Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Dise	2008
Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion Tensor Imaging; Disease P	2010
Characterization of preclinical models of prostate cancer using PET-based molecular imaging. European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:8 Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Line, Tumor; Choline; Disease Models, Anim	2009
Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease. Neuropediatrics, 2008, Volume: 39, Issue:5 Topics: Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Child, Preschool; Choline; Corpus Callosum; Cr	2008
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy. Psychiatry research, 2009, Jul-15, Volume: 173, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De	2009
A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:3 Topics: Adolescent; Aspartic Acid; Brain; Child; Choline; Creatine; Disease Progression; Down-Regulation; El	2010
Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis. Pediatric neurology, 2009, Volume: 41, Issue:3 Topics: Aspartic Acid; Bone Marrow; Brain; Child; Choline; Diagnosis, Differential; Disease Progression; Fat	2009
(1)H MRSI and progression-free survival in patients with WHO grades II and III gliomas. Neurological research, 2010, Volume: 32, Issue:6 Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Disease Progression; Disease-Free Survival; Female;	2010
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging. Neuroradiology, 2010, Volume: 52, Issue:4 Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr	2010
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free radical biology & medicine, 2010, Jan-15, Volume: 48, Issue:2 Topics: Animals; Choline; Cyclooxygenase 2; Disease Progression; Fatty Liver; Food, Formulated; Interleukin-	2010
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:2 Topics: Animal Feed; Animals; Choline; Choline Deficiency; Disease Progression; Fatty Liver; Lipid Peroxidat	2010
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology. Journal of neurotrauma, 2010, Volume: 27, Issue:3 Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Imm	2010
Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice. Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:12 Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Antioxidants; Carnitine O-Palmitoyltransferase; Choline;	2010
1H-14N HSQC detection of choline-containing compounds in solutions. Journal of magnetic resonance (San Diego, Calif. : 1997), 2010, Volume: 206, Issue:1 Topics: Algorithms; Animals; Choline; Dairy Products; Deuterium Oxide; Disease Progression; Magnetic Resonan	2010
Metabolic signatures of malignant progression in prostate epithelial cells. The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7 Topics: Amino Acids; Animals; Biomarkers, Tumor; Cell Line; Choline; Disease Progression; Epithelial Cells;	2011
Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients. Journal of psychiatric research, 2011, Volume: 45, Issue:4 Topics: Adult; Age of Onset; Aspartic Acid; Choline; Chronic Disease; Depressive Disorder, Major; Disease Pr	2011
Quantitative in vivo brain magnetic resonance spectroscopic monitoring of neurological involvement in mucopolysaccharidosis type II (Hunter Syndrome). Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3 Topics: Adolescent; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Case-Control Studies; Child; Child, Pre	2010
Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen. Journal of neuro-oncology, 2011, Volume: 103, Issue:3 Topics: Adolescent; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anti	2011
Diffusion-weighted imaging and magnetic resonance spectroscopy of sporadic Creutzfeldt-Jakob disease: correlation with clinical course. Neuroradiology, 2011, Volume: 53, Issue:12 Topics: Aged; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Creutzfeldt-Jakob Syndrome; Diffusion Mag	2011
Temporal evolution of sporadic Creutzfeldt-Jakob disease monitored by 3-Tesla MR spectroscopy. Journal of neurology, 2011, Volume: 258, Issue:7 Topics: Aged; Aspartic Acid; Choline; Creutzfeldt-Jakob Syndrome; Disease Progression; Female; Humans; Magne	2011
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:4 Topics: Animals; Choline; Choline-Phosphate Cytidylyltransferase; Dietary Fats; Dietary Supplements; Disease	2012
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI). Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:12 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female;	2011
Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence. Cancer prevention research (Philadelphia, Pa.), 2012, Volume: 5, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Choline; Dec	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 2012, Feb-01, Volume: 482, Issue:7384 Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline;	2012
The imaging diagnosis and prognosis assessment of patients with midbrain injury in the acute phase of craniocerebral injury. Acta neurochirurgica. Supplement, 2012, Volume: 114 Topics: Adolescent; Adult; Aspartic Acid; Child; Choline; Craniocerebral Trauma; Creatine; Disease Progressi	2012
Comparative study of the value of dual tracer PET/CT in evaluating breast cancer. Cancer science, 2012, Volume: 103, Issue:9 Topics: Adult; Aged; Breast Neoplasms; Choline; Disease Progression; Female; Fluorodeoxyglucose F18; Humans;	2012
Impact of total PSA, PSA doubling time and PSA velocity on detection rates of 11C-Choline positron emission tomography in recurrent prostate cancer. World journal of urology, 2013, Volume: 31, Issue:2 Topics: Aged; Biomarkers, Tumor; Carbon Radioisotopes; Choline; Disease Progression; Humans; Kallikreins; Ma	2013
Unusual manifestations of pediatric neuromyelitis optica. Journal of child neurology, 2013, Volume: 28, Issue:5 Topics: Adolescent; Anti-Inflammatory Agents; Azathioprine; Brain; Choline; Diagnosis, Differential; Disease	2013
18F-Fluoroethylcholine PET/CT identifies lymph node metastasis in patients with prostate-specific antigen failure after radical prostatectomy but underestimates its extent. European urology, 2013, Volume: 63, Issue:5 Topics: Aged; Choline; Disease Progression; Humans; Kallikreins; Lymph Node Excision; Lymph Nodes; Lymphatic	2013
Choline intake and risk of lethal prostate cancer: incidence and survival. The American journal of clinical nutrition, 2012, Volume: 96, Issue:4 Topics: Adult; Aged; Betaine; Choline; Cohort Studies; Diet; Disease Progression; Follow-Up Studies; Health	2012
Relationship between cervical cord 1H-magnetic resonance spectroscopy and clinoco-electromyographic profile in amyotrophic lateral sclerosis. Muscle & nerve, 2013, Volume: 47, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Cervical Vertebrae; Choline; Creatine; Disease Progression; Electromy	2013
Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. Journal of neurochemistry, 2003, Volume: 84, Issue:5 Topics: Animals; Apoptosis; Aziridines; Brain Ischemia; Cells, Cultured; Choline; Dicumarol; Disease Models,	2003
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. Experimental neurology, 2003, Volume: 179, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus S	2003
Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes? Neurology, 2003, Apr-22, Volume: 60, Issue:8 Topics: Adult; Aspartic Acid; Atrophy; Brain Stem; Choline; Creatinine; Disease Progression; Evoked Potentia	2003
Progression of liver lesions produced in rats by temporary treatment with pyrrolizidine (senecio) alkaloids, and the effects of betaine and high casein diet. British journal of cancer, 1957, Volume: 11, Issue:4 Topics: Animals; Betaine; Caseins; Choline; Diet; Disease Progression; Gastrointestinal Diseases; Liver Neop	1957
Pantothenate kinase-associated neurodegeneration: MR imaging, proton MR spectroscopy, and diffusion MR imaging findings. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:8 Topics: Adolescent; Aspartic Acid; Brain; Cerebellar Nuclei; Choline; Creatine; Diagnosis, Differential; Dif	2003
Alexander disease with serial MRS and a new mutation in the glial fibrillary acidic protein gene. Neurology, 2003, Oct-14, Volume: 61, Issue:7 Topics: Acidosis, Respiratory; Alexander Disease; Basal Ganglia; Choline; Creatine; Disease Progression; DNA	2003
(1)H magnetic resonance spectroscopy of preinvasive and invasive cervical cancer: in vivo-ex vivo profiles and effect of tumor load. Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:3 Topics: Adenocarcinoma; Adult; Aged; Analysis of Variance; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chol	2004
Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors. Cancer, 2004, Mar-15, Volume: 100, Issue:6 Topics: Adolescent; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Child, Preschool; Choline; Disea	2004
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS. BMC neuroscience, 2004, Mar-05, Volume: 5 Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat	2004
Leukoencephalopathy, cerebral calcifications, and cysts: new observations. Neurology, 2004, Apr-13, Volume: 62, Issue:7 Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Calcinosis; Central Nervous System Cysts; Child; C	2004
MR imaging and proton MR spectroscopic studies in Sjögren-Larsson syndrome: characterization of the leukoencephalopathy. AJNR. American journal of neuroradiology, 2004, Volume: 25, Issue:4 Topics: Adolescent; Adult; Aspartic Acid; Brain; Cerebral Ventricles; Child; Child, Preschool; Choline; Crea	2004
Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings. Journal of child neurology, 2004, Volume: 19, Issue:3 Topics: Aspartic Acid; Brain; Cerebral Cortex; Child, Preschool; Choline; Creatine; Diagnosis, Differential;	2004
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. Journal of neurochemistry, 2004, Volume: 89, Issue:5 Topics: Acute Disease; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chronic Disease; Disease Mode	2004
Five new cases of a recently described leukoencephalopathy with high brain lactate. Neurology, 2004, Aug-24, Volume: 63, Issue:4 Topics: Adolescent; Aspartic Acid; Ataxia; Brain Chemistry; Brain Diseases, Metabolic; Brain Stem; Central N	2004
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma. Journal of neurosurgery, 2004, Volume: 101, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor	2004
Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology, 2004, Sep-14, Volume: 63, Issue:5 Topics: Adult; Aspartic Acid; Cerebellum; Cerebral Cortex; Choline; Creatine; Disease Progression; Female; H	2004
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. Journal of neurotrauma, 2004, Volume: 21, Issue:11 Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Com	2004
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. Journal of neuro-oncology, 2005, Volume: 71, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous Syst	2005
[Choline- and histaminergic shifts as a trigger of gastroduodenal erosive-ulcer lesions in myocardial infarction]. Terapevticheskii arkhiv, 2005, Volume: 77, Issue:2 Topics: Adolescent; Adult; Aged; Choline; Disease Progression; Female; Histamine; Humans; Hyperhomocysteinem	2005
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. International journal of radiation oncology, biology, physics, 2005, May-01, Volume: 62, Issue:1 Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression	2005
Leukoencephalopathy with ataxia, hypodontia, and hypomyelination. Neurology, 2005, Apr-26, Volume: 64, Issue:8 Topics: Age of Onset; Anodontia; Ataxia; Atrophy; Basal Ganglia; Body Height; Brain; Cerebellum; Child; Chil	2005
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy. Neurobiology of aging, 2006, Volume: 27, Issue:7 Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis	2006
Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer research, 2005, Oct-15, Volume: 65, Issue:20 Topics: Carbon Radioisotopes; Cell Line, Tumor; Choline; Choline Kinase; Disease Progression; Female; Humans	2005
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats. Gut, 2006, Volume: 55, Issue:7 Topics: Animals; Bile Ducts; Carbon Tetrachloride; Choline; Collagen Type I; Disease Progression; Hypoglycem	2006
Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis. Journal of child neurology, 2006, Volume: 21, Issue:2 Topics: Adolescent; Antiviral Agents; Artifacts; Aspartic Acid; Choline; Disease Progression; Dominance, Cer	2006
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2006, Volume: 178, Issue:6 Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined	2006
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging, 2007, Volume: 28, Issue:9 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition	2007
Contribution of 11C-choline positron emission tomography/computerized tomography to preoperative staging of advanced transitional cell carcinoma. The Journal of urology, 2006, Volume: 176, Issue:3 Topics: Aged; Aged, 80 and over; Carbon Radioisotopes; Carcinoma, Transitional Cell; Choline; Disease Progre	2006
Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia (New York, N.Y.), 2006, Volume: 8, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Choline; Disease Progre	2006
Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:4 Topics: Animals; Carcinoma, Hepatocellular; Choline; Disease Models, Animal; Disease Progression; Fatty Live	2006
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. Neurobiology of disease, 2007, Volume: 26, Issue:3 Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models,	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, Jul-03, Volume: 69, Issue:1 Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female;	2007
Magnetic resonance spectroscopy in adult-onset citrullinemia: elevated glutamine levels in comatose patients. Archives of neurology, 2007, Volume: 64, Issue:7 Topics: Adult; Ammonia; Biomarkers; Brain; Brain Mapping; Cerebral Cortex; Choline; Citrulline; Citrullinemi	2007
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas. European neurology, 2007, Volume: 58, Issue:4 Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma;	2007
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Digestive diseases and sciences, 2008, Volume: 53, Issue:10 Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated	2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats. Journal of neurotrauma, 2008, Volume: 25, Issue:6 Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C	2008
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. Journal of neurosurgery, 1997, Volume: 87, Issue:4 Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas	1997
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy. Journal of neurosurgery, 1997, Volume: 87, Issue:4 Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Pro	1997
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:2 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Huma	1998
Proton magnetic resonance spectroscopy of linear nevus sebaceus syndrome. Pediatric neurology, 1998, Volume: 18, Issue:2 Topics: Aspartic Acid; Brain Chemistry; Cerebral Cortex; Child, Preschool; Choline; Creatine; Disease Progre	1998
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 1999, Volume: 9, Issue:2 Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Pro	1999
Usefulness of proton magnetic resonance spectroscopy in differentiating parkinsonian syndromes. Italian journal of neurological sciences, 1999, Volume: 20, Issue:4 Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Diagnosis, Differential; Disease Progression;	1999
MR spectroscopy in gliomatosis cerebri. AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Choline; Creatine; Di	2000
Cerebrospinal fluid free choline in movement disorders of paediatric onset. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 1998, Volume: 2, Issue:1 Topics: Acetylcholine; Adrenocorticotropic Hormone; Adult; Child; Child, Preschool; Choline; Chromatography,	1998
Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis. NMR in biomedicine, 2000, Volume: 13, Issue:2 Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Humans; Magnetic	2000
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study. Neurology, 2000, Jul-25, Volume: 55, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorde	2000
Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis. Archives of neurology, 2001, Volume: 58, Issue:5 Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female;	2001
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure. Circulation, 2001, Jun-12, Volume: 103, Issue:23 Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Hu	2001
Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency. Neuropediatrics, 2000, Volume: 31, Issue:6 Topics: Amino Acids; Carbohydrate Dehydrogenases; Cerebral Cortex; Child; Child, Preschool; Choline; Demyeli	2000
Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:2 Topics: Adolescent; Blood Volume; Brain Neoplasms; Cerebrovascular Circulation; Child; Child, Preschool; Cho	2002
Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology, 2002, Mar-12, Volume: 58, Issue:5 Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Disease Progression; Female; Humans	2002

choline and Disease Exacerbation