choline has been researched along with Depressive Disorder in 33 studies
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle." | 3.96 | Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020) |
| "Partial or total overnight sleep deprivation produces immediate mood improvement in about 50% of patients with depression, but not in healthy controls." | 1.35 | Effects of overnight sleep restriction on brain chemistry and mood in women with unipolar depression and healthy controls. ( Bartha, R; Bernier, D; Devarajan, S; Macmaster, FP; Rusak, B; Schmidt, MH, 2009) |
| "Cholinergic processes were measured in plasma and red blood cells (RBC) obtained from patients with mania, depression, and schizophrenia." | 1.27 | Cholinergic processes in blood samples from patients with major psychiatric disorders. ( Alarcon, RD; Jope, RS; Lally, KM; Walter-Ryan, WG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (42.42) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Kochalska, K | 1 |
| Oakden, W | 1 |
| Słowik, T | 1 |
| Chudzik, A | 1 |
| Pankowska, A | 1 |
| Łazorczyk, A | 1 |
| Kozioł, P | 1 |
| Andres-Mach, M | 1 |
| Pietura, R | 1 |
| Rola, R | 1 |
| Stanisz, GJ | 1 |
| Orzylowska, A | 1 |
| Henigsberg, N | 1 |
| Savić, A | 1 |
| Radoš, M | 2 |
| Šarac, H | 1 |
| Ozretić, D | 1 |
| Bajs Janović, M | 1 |
| Erdeljić Turk, V | 1 |
| Šečić, A | 1 |
| Kalember, P | 1 |
| Hrabač, P | 1 |
| Li, H | 1 |
| Xu, H | 1 |
| Zhang, Y | 1 |
| Guan, J | 1 |
| Zhang, J | 2 |
| Xu, C | 1 |
| Shen, Z | 1 |
| Xiao, B | 1 |
| Liang, C | 1 |
| Chen, K | 1 |
| Wu, R | 1 |
| Hong, ST | 1 |
| Choi, CB | 1 |
| Park, C | 1 |
| Moon, HY | 1 |
| Hong, KS | 1 |
| Cheong, C | 1 |
| Chae, JH | 1 |
| Choe, BY | 1 |
| Bernier, D | 1 |
| Bartha, R | 1 |
| Devarajan, S | 1 |
| Macmaster, FP | 1 |
| Schmidt, MH | 1 |
| Rusak, B | 1 |
| Herman-Sucharska, I | 1 |
| Werewka-Maczuga, A | 1 |
| Urbanik, A | 2 |
| Rachel, W | 1 |
| Siwek, M | 1 |
| Dudek, D | 1 |
| Zieba, A | 1 |
| FORSTER, FM | 1 |
| BORKOWSKI, WJ | 1 |
| McCARTER, RH | 1 |
| Farchione, TR | 1 |
| Moore, GJ | 1 |
| Rosenberg, DR | 1 |
| Sartorius, A | 1 |
| Neumann-Haefelin, C | 1 |
| Vollmayr, B | 1 |
| Hoehn, M | 1 |
| Henn, FA | 1 |
| CIMINO, JP | 1 |
| Modica-Napolitano, JS | 1 |
| Renshaw, PF | 2 |
| Sanacora, G | 1 |
| Gueorguieva, R | 1 |
| Epperson, CN | 1 |
| Wu, YT | 1 |
| Appel, M | 1 |
| Rothman, DL | 1 |
| Krystal, JH | 1 |
| Mason, GF | 1 |
| Elderkin-Thompson, V | 1 |
| Thomas, MA | 2 |
| Binesh, N | 2 |
| Mintz, J | 2 |
| Haroon, E | 1 |
| Dunkin, JJ | 1 |
| Kumar, A | 2 |
| Hwang, S | 1 |
| Kado, H | 1 |
| Kimura, H | 1 |
| Murata, T | 1 |
| Nagata, K | 1 |
| Kanno, I | 1 |
| Glodzik-Sobanska, L | 1 |
| Slowik, A | 1 |
| McHugh, P | 1 |
| Sobiecka, B | 1 |
| Kozub, J | 1 |
| Rich, KE | 1 |
| Szczudlik, A | 1 |
| Murphy, MF | 1 |
| Davis, KL | 1 |
| Haag, M | 1 |
| Haag, H | 1 |
| Eisenried, F | 1 |
| Greil, W | 1 |
| Gerner, RH | 2 |
| Cohen, DJ | 2 |
| Fairbanks, L | 2 |
| Anderson, GM | 2 |
| Young, JG | 2 |
| Scheinin, M | 2 |
| Linnoila, M | 2 |
| Shaywitz, BA | 2 |
| Hare, TA | 2 |
| Spar, JE | 1 |
| Wood, PL | 1 |
| Suranyi-Cadotte, B | 1 |
| Schwartz, G | 1 |
| Nair, NP | 1 |
| Deutsch, SI | 1 |
| Stanley, M | 1 |
| Peselow, ED | 1 |
| Banay-Schwartz, M | 1 |
| Hanin, I | 4 |
| Reynolds, CF | 2 |
| Kupfer, DJ | 2 |
| Kopp, U | 3 |
| Taska, LS | 1 |
| Hoch, CC | 1 |
| Spiker, DG | 2 |
| Sewitch, DE | 1 |
| Martin, D | 1 |
| Marin, RS | 1 |
| Neil, JF | 1 |
| Shaw, DH | 1 |
| Charles, HC | 1 |
| Lazeyras, F | 1 |
| Krishnan, KR | 1 |
| Boyko, OB | 1 |
| Payne, M | 1 |
| Moore, D | 1 |
| Hamakawa, H | 1 |
| Kato, T | 1 |
| Murashita, J | 1 |
| Kato, N | 1 |
| Sonawalla, SB | 1 |
| Moore, CM | 1 |
| Alpert, JE | 1 |
| Nierenberg, AA | 1 |
| Rosenbaum, JF | 1 |
| Fava, M | 1 |
| Sharma, R | 1 |
| Venkatasubramanian, PN | 1 |
| Bárány, M | 1 |
| Davis, JM | 1 |
| Stoll, AL | 1 |
| Cohen, BM | 1 |
| Houck, PR | 1 |
| Uney, JB | 1 |
| Duggan, C | 1 |
| Marchbanks, RM | 1 |
| Jacoby, R | 1 |
| Jope, RS | 1 |
| Walter-Ryan, WG | 1 |
| Alarcon, RD | 1 |
| Lally, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Intraoperative Low-dose Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression Undergoing Cesarean Delivery: Blind Test, Randomized, Placebo-controlled Trial[NCT03336541] | Phase 4 | 64 participants (Actual) | Interventional | 2017-11-23 | Completed | ||
| A Randomized Controlled Trial to Decrease Suicidal Thinking Using Ketamine[NCT02418702] | Phase 3 | 0 participants (Actual) | Interventional | 2016-08-31 | Withdrawn (stopped due to PI no longer at facility.) | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
2 reviews available for choline and Depressive Disorder
| Article | Year |
|---|---|
Biological perspectives in chronic pain, depression, and organic mental disorders.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Animals; Antidepressive Agents; Antipsychotic Agents; Chol | 1981 |
Glycine: a possible role in lithium's action and affective illness.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Autistic Disorder; Bipolar Disorder; Brain Chemistry; | 1983 |
2 trials available for choline and Depressive Disorder
| Article | Year |
|---|---|
Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.
Topics: Aged; Antidepressive Agents; Aspartic Acid; Brain Chemistry; Choline; Depressive Disorder; Humans; I | 1994 |
Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine.
Topics: Adult; Ambulatory Care; Analysis of Variance; Basal Ganglia; Biomarkers; Choline; Creatine; Cytosol; | 1999 |
29 other studies available for choline and Depressive Disorder
| Article | Year |
|---|---|
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements; | 2020 |
Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective
Topics: Adolescent; Adult; Antidepressive Agents; Aspartic Acid; Biomarkers; Choline; Depressive Disorder; F | 2018 |
Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Female; Gyrus Cingul | 2016 |
Specific hippocampal choline decrease in an animal model of depression.
Topics: Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Depressive Disorder; Hippocampus; Magnetic Re | 2009 |
Effects of overnight sleep restriction on brain chemistry and mood in women with unipolar depression and healthy controls.
Topics: Adult; Affect; Analysis of Variance; Aspartic Acid; Choline; Creatine; Depressive Disorder; Female; | 2009 |
[Usefulness of proton MR spectroscopy for determining diagnosis and treatment outcome in unipolar depressive disorder].
Topics: Adolescent; Adult; Choline; Creatine; Depressive Disorder; Frontal Lobe; Hippocampus; Humans; Magnet | 2010 |
Depression of the cerebral cortex induced by applications of acetylcholine.
Topics: Acetylcholine; Brain; Cerebral Cortex; Choline; Depression; Depressive Disorder; Humans | 1946 |
Proton magnetic resonance spectroscopic imaging in pediatric major depression.
Topics: Adolescent; Analysis of Variance; Child; Choline; Depressive Disorder; Female; Humans; Magnetic Reso | 2002 |
Choline rise in the rat hippocampus induced by electroconvulsive shock treatment.
Topics: Animals; Choline; Depressive Disorder; Electroconvulsive Therapy; Hippocampus; Magnetic Resonance Sp | 2003 |
Use of deanol in treatment of chronic fatigue and mild endogenous depression.
Topics: Aminobenzoates; Choline; Deanol; Depression; Depressive Disorder; Fatigue; Humans | 1959 |
Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder.
Topics: Animals; Bipolar Disorder; Choline; Depressive Disorder; Dose-Response Relationship, Drug; Ethanolam | 2004 |
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso | 2004 |
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso | 2004 |
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso | 2004 |
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso | 2004 |
Brain metabolites and cognitive function among older depressed and healthy individuals using 2D MR spectroscopy.
Topics: Age Factors; Aged; Aged, 80 and over; Brain; Case-Control Studies; Choline; Cognition; Creatine; Dep | 2004 |
Neurochemistry of late-life major depression: a pilot two-dimensional MR spectroscopic study.
Topics: Aged; Aged, 80 and over; Brain Chemistry; Choline; Creatine; Depressive Disorder; Female; Humans; Ma | 2004 |
Depressive psychosis: clinical usefulness of MR spectroscopy data in predicting prognosis.
Topics: Aged; Analysis of Variance; Antidepressive Agents; Area Under Curve; Aspartic Acid; Choline; Creatin | 2006 |
Single voxel proton magnetic resonance spectroscopy in post-stroke depression.
Topics: Aged; Aspartic Acid; Cerebral Infarction; Choline; Creatine; Depressive Disorder; Dominance, Cerebra | 2006 |
RBC-choline: changes by lithium and relation to prophylactic response.
Topics: Age Factors; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Choline; Depressive Diso | 1984 |
CSF neurochemistry of women with anorexia nervosa and normal women.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Calcium; Choline; Depressive Disorder; Female; gam | 1984 |
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls.
Topics: Adolescent; Adult; Age Factors; Aged; Bipolar Disorder; Calcium; Choline; Depressive Disorder; Femal | 1984 |
Dementia in the aged.
Topics: Aged; Cerebral Infarction; Choline; Creutzfeldt-Jakob Syndrome; Dementia; Depressive Disorder; Diagn | 1982 |
Platelet 3H-imipramine binding and red blood cell choline in affective disorders: indications of heterogeneous pathogenesis.
Topics: Bipolar Disorder; Blood Platelets; Carrier Proteins; Choline; Depressive Disorder; Humans; Imipramin | 1983 |
Elevated red blood cell/plasma choline ratio in dementia of the Alzheimer type: clinical and polysomnographic correlates.
Topics: Aged; Alzheimer Disease; Choline; Depressive Disorder; Erythrocytes; Female; Humans; Male; Middle Ag | 1984 |
RBC and plasma choline levels in control and depressed individuals: a critical evaluation.
Topics: Adolescent; Adult; Choline; Depressive Disorder; Erythrocytes; Female; Humans; Male; Middle Aged; Pl | 1980 |
Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Femal | 1998 |
Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Energ | 1992 |
Erythrocyte choline concentrations in psychiatric disorders.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Bipolar Disorder; Choline; Dementia; Depressi | 1991 |
Red blood cell/plasma choline ratio in elderly depressed and demented patients.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Depressive Disorder; Electroencephalography; Erythrocyte | 1988 |
A pilot study of erythrocyte choline flux and content in affective disorders.
Topics: Adult; Age Factors; Bipolar Disorder; Cell Membrane Permeability; Choline; Depressive Disorder; Eryt | 1986 |
Cholinergic processes in blood samples from patients with major psychiatric disorders.
Topics: Acetylcholinesterase; Bipolar Disorder; Choline; Cholinesterases; Depressive Disorder; Erythrocytes; | 1985 |