choline has been researched along with Dementia in 88 studies
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the associations of dietary choline intake with the risk of incident dementia and with cognitive performance in middle-aged and older men in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study." | 9.30 | Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. ( Lönnroos, E; Salonen, JT; Tuomainen, TP; Virtanen, HEK; Virtanen, JK; Voutilainen, S; Ylilauri, MPT, 2019) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 7.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 7.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia." | 7.66 | Presynaptic cholinergic dysfunction in patients with dementia. ( Allen, SJ; Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC; Thomas, DJ, 1983) |
| "The cholinergic system has been found to be crucially involved in cognitive function, with cholinergic dysfunction playing a pivotal role in the pathophysiology of dementia." | 6.53 | Cholinergic imaging in dementia spectrum disorders. ( Niccolini, F; Pagano, G; Politis, M; Roy, R, 2016) |
| "We investigated the associations of dietary choline intake with the risk of incident dementia and with cognitive performance in middle-aged and older men in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study." | 5.30 | Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. ( Lönnroos, E; Salonen, JT; Tuomainen, TP; Virtanen, HEK; Virtanen, JK; Voutilainen, S; Ylilauri, MPT, 2019) |
| "Mice with dementia were produced by mating sibling mice who had impaired memory for > 20 generations." | 5.29 | Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. ( Chung, SY; Hirata, R; Kokubu, T; Masuda, Y; Moriyama, T; Uezu, E; Uezu, K; Yamamoto, S; Yohena, N, 1995) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 5.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily." | 5.26 | [Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979) |
| "Plasmas of 12 patients currently taking part in a double-blind trial of lecithin in senile or presenile dementia of Alzheimer type were analysed for plasma choline levels at fixed intervals during lecithin treatment." | 5.05 | Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations. ( Chuaqui, P; Levy, R, 1982) |
| "We examined prospective associations of TMAO, γ-butyrobetaine, crotonobetaine, carnitine, choline, and betaine with risk of cognitive impairment and dementia among older adults aged 65 years and older in the Cardiovascular Health Study (CHS)." | 4.12 | Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study. ( de Oliveira Otto, MC; Fretts, A; Hazen, SL; Lai, HTM; Lee, Y; Lemaitre, RN; Li, XS; Lopez, O; Mozaffarian, D; Nemet, I; Newman, AB; Siscovick, DS; Tang, WHW; Wang, M; Wang, Z, 2022) |
| " Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity." | 3.71 | Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. ( Alexander, GE; Chang, L; Huang, W; Krasuski, JS; Rapoport, SI; Schapiro, MB; Shetty, HU, 2001) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 3.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 3.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia." | 3.66 | Presynaptic cholinergic dysfunction in patients with dementia. ( Allen, SJ; Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC; Thomas, DJ, 1983) |
| "Recent studies have shown a defect in the cholinergic system of the cerebral cortex of patients suffering from nonvascular senile dementia." | 3.66 | Will drugs help patients with Alzheimer's disease? ( Kendall, MJ, 1979) |
| "Dementia was an independent predictor of metabolite values." | 2.73 | Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008) |
| "Choline is a critical nutrient for cognitive development, metabolism and liver function, and regulation of homocysteine metabolism." | 2.72 | [Importance of choline in cognitive function]. ( Aparicio, A; López-Sobaler, AM; Lorenzo Mora, AM; Ortega, RMª; Peral Suárez, Á; Salas González, MªD, 2021) |
| "The cholinergic system has been found to be crucially involved in cognitive function, with cholinergic dysfunction playing a pivotal role in the pathophysiology of dementia." | 2.53 | Cholinergic imaging in dementia spectrum disorders. ( Niccolini, F; Pagano, G; Politis, M; Roy, R, 2016) |
| "We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD)." | 1.40 | Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. ( Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M, 2014) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| "Mice with dementia were produced by mating sibling mice who had impaired memory for > 20 generations." | 1.29 | Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. ( Chung, SY; Hirata, R; Kokubu, T; Masuda, Y; Moriyama, T; Uezu, E; Uezu, K; Yamamoto, S; Yohena, N, 1995) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 1.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily." | 1.26 | [Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (62.50) | 18.7374 |
| 1990's | 9 (10.23) | 18.2507 |
| 2000's | 12 (13.64) | 29.6817 |
| 2010's | 9 (10.23) | 24.3611 |
| 2020's | 3 (3.41) | 2.80 |
| Authors | Studies |
|---|---|
| de Oliveira Otto, MC | 1 |
| Li, XS | 1 |
| Wang, Z | 1 |
| Siscovick, DS | 1 |
| Newman, AB | 1 |
| Lai, HTM | 1 |
| Nemet, I | 1 |
| Lee, Y | 1 |
| Wang, M | 1 |
| Fretts, A | 1 |
| Lemaitre, RN | 1 |
| Tang, WHW | 1 |
| Lopez, O | 1 |
| Hazen, SL | 1 |
| Mozaffarian, D | 1 |
| Shea, TB | 1 |
| Hildre, AS | 1 |
| Solvang, SH | 1 |
| Aarsland, D | 1 |
| Midtun, Ø | 1 |
| McCann, A | 1 |
| Ervik, AO | 1 |
| Nygård, O | 1 |
| Ueland, PM | 1 |
| Nordrehaug, JE | 1 |
| Giil, LM | 1 |
| López-Sobaler, AM | 1 |
| Lorenzo Mora, AM | 1 |
| Salas González, MªD | 1 |
| Peral Suárez, Á | 1 |
| Aparicio, A | 1 |
| Ortega, RMª | 1 |
| Reddan, JM | 1 |
| Macpherson, H | 1 |
| White, DJ | 1 |
| Scholey, A | 1 |
| Pipingas, A | 1 |
| Ylilauri, MPT | 1 |
| Voutilainen, S | 1 |
| Lönnroos, E | 1 |
| Virtanen, HEK | 1 |
| Tuomainen, TP | 1 |
| Salonen, JT | 1 |
| Virtanen, JK | 1 |
| Herrmann, W | 1 |
| Obeid, R | 1 |
| Kantarci, K | 2 |
| Targosz-Gajniak, MG | 1 |
| Siuda, JS | 1 |
| Wicher, MM | 1 |
| Banasik, TJ | 1 |
| Bujak, MA | 1 |
| Augusciak-Duma, AM | 1 |
| Opala, G | 1 |
| Waragai, M | 1 |
| Hata, S | 1 |
| Suzuki, T | 1 |
| Ishii, R | 1 |
| Fujii, C | 1 |
| Tokuda, T | 1 |
| Arai, H | 1 |
| Ohrui, T | 1 |
| Higuchi, S | 1 |
| Yoshida, M | 1 |
| Igarashi, K | 1 |
| Moriya, M | 1 |
| Iwai, N | 1 |
| Uemura, K | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Roy, R | 1 |
| Niccolini, F | 1 |
| Pagano, G | 1 |
| Politis, M | 1 |
| García Santos, JM | 1 |
| Gavrila, D | 1 |
| Antúnez, C | 1 |
| Tormo, MJ | 1 |
| Salmerón, D | 1 |
| Carles, R | 1 |
| Jiménez Veiga, J | 1 |
| Parrilla, G | 1 |
| Torres del Río, S | 1 |
| Fortuna, L | 1 |
| Navarro, C | 1 |
| Caserta, MT | 1 |
| Ragin, A | 1 |
| Hermida, AP | 1 |
| Ahrens, RJ | 1 |
| Wise, L | 1 |
| Pilatus, U | 1 |
| Lais, C | 1 |
| Rochmont, Adu M | 1 |
| Kratzsch, T | 1 |
| Frölich, L | 1 |
| Maurer, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pantel, J | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Kizu, O | 1 |
| Yamada, K | 1 |
| Ito, H | 1 |
| Nishimura, T | 1 |
| Petersen, RC | 1 |
| Boeve, BF | 1 |
| Knopman, DS | 1 |
| Tang-Wai, DF | 1 |
| O'Brien, PC | 1 |
| Weigand, SD | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Jack, CR | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 3 |
| Renshaw, PF | 2 |
| Pfefferbaum, A | 1 |
| Adalsteinsson, E | 1 |
| Sullivan, EV | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 1 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Pelliccioli, GP | 1 |
| Gobbi, G | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Rami, L | 1 |
| Caprile, C | 1 |
| Gómez-Ansón, B | 1 |
| Sánchez-Valle, R | 1 |
| Monte, GC | 1 |
| Bosch, B | 1 |
| Molinuevo, JL | 1 |
| Xuan, X | 1 |
| Ding, M | 1 |
| Gong, X | 1 |
| Jolles, J | 1 |
| Verhoeven, WM | 1 |
| Hier, DB | 1 |
| Caplan, LR | 1 |
| Carolei, A | 1 |
| Di Piero, V | 1 |
| Squitieri, G | 1 |
| Murphy, MF | 1 |
| Davis, KL | 3 |
| McGeer, EG | 1 |
| Fisman, M | 2 |
| Pomara, N | 4 |
| Stanley, M | 2 |
| Flentge, F | 1 |
| van den Berg, CJ | 1 |
| Davies, P | 1 |
| Kameyama, M | 1 |
| Spar, JE | 1 |
| Price, DL | 1 |
| Whitehouse, PJ | 1 |
| Struble, RG | 1 |
| Coyle, JT | 1 |
| Clark, AW | 1 |
| Delong, MR | 1 |
| Cork, LC | 1 |
| Hedreen, JC | 1 |
| Banay-Schwartz, M | 1 |
| Block, R | 1 |
| Gershon, S | 2 |
| Maire, JC | 1 |
| Wurtman, RJ | 2 |
| Vatassery, GT | 1 |
| Maletta, GJ | 1 |
| Paggi, A | 1 |
| Quattrini, A | 1 |
| Ortenzi, A | 1 |
| Cianci, F | 1 |
| Silvestri, R | 1 |
| Mancini, S | 1 |
| Ball, MJ | 1 |
| Marchbanks, RM | 2 |
| Sims, NR | 1 |
| Bowen, DM | 2 |
| Allen, SJ | 1 |
| Smith, CC | 1 |
| Neary, D | 1 |
| Thomas, DJ | 1 |
| Davison, AN | 2 |
| Lamb, K | 1 |
| Bradshaw, CM | 1 |
| Szabadi, E | 1 |
| Stramba-Badiale, M | 1 |
| Scillieri, E | 1 |
| Domino, EF | 2 |
| Yoon, H | 1 |
| Brinkman, S | 1 |
| Tamminga, CA | 1 |
| Canter, NL | 1 |
| Hallett, M | 1 |
| Growdon, JH | 2 |
| Merskey, H | 1 |
| Helmes, E | 1 |
| McCready, J | 1 |
| Colhoun, EH | 1 |
| Rylett, BJ | 1 |
| Chuaqui, P | 1 |
| Levy, R | 2 |
| Barclay, LL | 1 |
| Blass, JP | 1 |
| Kopp, U | 2 |
| Hanin, I | 3 |
| Brinkman, SD | 1 |
| Goodnick, PJ | 1 |
| Barnett, N | 1 |
| Hsieh, JY | 1 |
| Levy, MI | 2 |
| Horvath, TB | 2 |
| Davis, BM | 2 |
| Mohs, RC | 2 |
| Etienne, P | 2 |
| Dastoor, D | 2 |
| Gauthier, S | 2 |
| Ludwick, R | 1 |
| Collier, B | 2 |
| Friedman, E | 1 |
| Sherman, KA | 1 |
| Ferris, SH | 1 |
| Reisberg, B | 1 |
| Bartus, RT | 1 |
| Schneck, MK | 1 |
| Glen, AI | 1 |
| Yates, CM | 1 |
| Simpson, J | 1 |
| Christie, JE | 1 |
| Shering, A | 1 |
| Whalley, LJ | 1 |
| Jellinek, EH | 1 |
| Kent, S | 1 |
| Thal, LJ | 2 |
| Rosen, W | 2 |
| Sharpless, NS | 2 |
| Crystal, H | 2 |
| Richter, JA | 1 |
| Perry, EK | 1 |
| Tomlinson, BE | 1 |
| Corkin, S | 1 |
| Fovall, P | 1 |
| Dysken, MW | 1 |
| Lazarus, LW | 1 |
| Davis, JM | 1 |
| Kahn, RL | 1 |
| Jope, R | 1 |
| Finkel, S | 1 |
| Rattan, P | 1 |
| Tinklenberg, JR | 1 |
| Rosenberg, GS | 1 |
| Constans, JM | 1 |
| Meyerhoff, DJ | 1 |
| Gerson, J | 1 |
| MacKay, S | 1 |
| Norman, D | 1 |
| Fein, G | 1 |
| Weiner, MW | 1 |
| Shonk, T | 1 |
| Ross, BD | 1 |
| Stoll, AL | 2 |
| Yurgelun-Todd, D | 1 |
| Babb, SM | 1 |
| Chung, SY | 1 |
| Moriyama, T | 1 |
| Uezu, E | 1 |
| Uezu, K | 1 |
| Hirata, R | 1 |
| Yohena, N | 1 |
| Masuda, Y | 1 |
| Kokubu, T | 1 |
| Yamamoto, S | 1 |
| Bowen, BC | 1 |
| Block, RE | 1 |
| Sanchez-Ramos, J | 1 |
| Pattany, PM | 1 |
| Lampman, DA | 1 |
| Murdoch, JB | 1 |
| Quencer, RM | 1 |
| Egashira, T | 1 |
| Kanfer, JN | 1 |
| Pettegrew, JW | 1 |
| Moossy, J | 1 |
| McCartney, DG | 1 |
| Huang, W | 1 |
| Alexander, GE | 1 |
| Chang, L | 1 |
| Shetty, HU | 1 |
| Krasuski, JS | 1 |
| Rapoport, SI | 1 |
| Schapiro, MB | 1 |
| Boyd, WD | 1 |
| Graham-White, J | 1 |
| Blackwood, G | 1 |
| Glen, I | 1 |
| McQueen, J | 1 |
| Spillane, JA | 1 |
| Goodhart, MJ | 1 |
| White, P | 1 |
| Johnson, G | 1 |
| Mendis, T | 1 |
| Cole, M | 1 |
| Muller, HF | 1 |
| Smith, CM | 2 |
| Swash, M | 2 |
| Exton-Smith, AN | 1 |
| Phillips, MJ | 1 |
| Overstall, PW | 1 |
| Piper, ME | 1 |
| Bailey, MR | 1 |
| Signoret, JL | 2 |
| Whiteley, A | 2 |
| Lhermitte, F | 2 |
| Kolata, GB | 1 |
| Renvoize, EB | 1 |
| Jerram, T | 1 |
| Kendall, MJ | 1 |
| Agid, Y | 1 |
| Aquilonius, SM | 1 |
| Ceder, G | 1 |
| Lying-Tunell, U | 1 |
| Malmlund, HO | 1 |
| Schuberth, J | 1 |
| Serra, F | 1 |
| Diaspri, GP | 1 |
| Gasbarrini, A | 1 |
| Giancane, S | 1 |
| Rimondi, A | 1 |
| Tamè, MR | 1 |
| Sakellaridis, E | 1 |
| Bernardi, M | 1 |
| Gasbarrini, G | 1 |
| Ohtomo, E | 1 |
| Nakahiro, M | 1 |
| Mochizuki, D | 1 |
| Uchida, S | 1 |
| Yoshida, H | 1 |
| Houck, PR | 1 |
| Reynolds, CF | 1 |
| Bonavita, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)[NCT03221127] | 2,682 participants (Actual) | Observational | 1984-03-01 | Active, not recruiting | |||
| Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477] | Phase 1 | 150 participants (Anticipated) | Interventional | 2016-09-30 | Enrolling by invitation | ||
| Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770] | 300 participants (Anticipated) | Interventional | 2019-12-01 | Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development) | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
14 reviews available for choline and Dementia
| Article | Year |
|---|---|
[Importance of choline in cognitive function].
Topics: Adult; Aged; Aged, 80 and over; Choline; Cognition; Dementia; Diet; Female; Humans; Middle Aged; Neu | 2021 |
Examining the relationship between nutrition and cerebral structural integrity in older adults without dementia.
Topics: Aged; Aged, 80 and over; Aging; Brain; Choline; Cognition; Cognitive Dysfunction; Dementia; Diet; Di | 2019 |
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
Cholinergic imaging in dementia spectrum disorders.
Topics: Choline; Dementia; Diagnostic Imaging; Humans; Synapses | 2016 |
[Psychopharmacologic treatment of cognitive function disorders in aging persons: current possibilities].
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Anticonvulsants; Brain; Catecholamines; Cholin | 1984 |
[Neurobiological and neurochemical aspects and therapeutic problems in aging and in dementia].
Topics: Age Factors; Aged; Aging; Brain Chemistry; Choline; Dementia; Humans; Nervous System; Nervous System | 1980 |
Biological perspectives in chronic pain, depression, and organic mental disorders.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Animals; Antidepressive Agents; Antipsychotic Agents; Chol | 1981 |
Neurotransmitter systems in aging and senile dementia.
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g | 1981 |
Clinical pharmacology of senile dementia.
Topics: Aged; Aging; Anticoagulants; Arginine Vasopressin; Brain; Choline; Dementia; Dihydroergotoxine; Free | 1981 |
An update on the neurochemistry of Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Arecoline; Brain; Choline; Choline O-Acetyltransferase; Cho | 1983 |
[Aging of the nervous system--with special reference to dementia in the aged].
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Dementia; Humans; | 1983 |
Alzheimer's disease: a challenging enigma.
Topics: Aging; Animals; Brain; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; De | 1982 |
Biochemistry of Alzheimer's dementia.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Choline; Ch | 1982 |
[Recent drug therapy of senile dementia].
Topics: Adrenocorticotropic Hormone; Alzheimer Disease; Choline; Dementia; Dihydroergotoxine; Humans; Narcot | 1987 |
13 trials available for choline and Dementia
| Article | Year |
|---|---|
Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Topics: Adult; Apolipoprotein E4; Choline; Cognition; Dementia; Diet; Eggs; Finland; Follow-Up Studies; Huma | 2019 |
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2008 |
Neurotransmitter systems in aging and senile dementia.
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g | 1981 |
Double blind study of lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; H | 1981 |
Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; M | 1982 |
A dose-ranging study of lecithin in the treatment of primary degenerative dementia (Alzheimer disease).
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Drug Evaluation; Erythrocytes; Fema | 1982 |
Alzheimer disease: lack of effect of lecithin treatment for 3 months.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Humans; Middle Aged; Phosphatidylch | 1981 |
Choline therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Drug Eval | 1978 |
Influence of choline on amnesia in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amnesia; Choline; Clinical Trials as Topic; Dementia; Humans; Memory; Middl | 1978 |
Choline in Alzheimers disease.
Topics: Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Humans; Research Design | 1978 |
Mental disorders: a new approach to treatment?
Topics: Acetylcholine; Brain; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Dyskinesia, | 1979 |
Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; H | 1979 |
[Effect of CDP-choline on senile mental deterioration. Multicenter experience on 237 cases].
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Choline; Cytidine Diphosphate Choline; Dementia | 1990 |
62 other studies available for choline and Dementia
| Article | Year |
|---|---|
Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study.
Topics: Animals; Betaine; Carnitine; Choline; Cognitive Dysfunction; Dementia; Medicare; Methylamines; Unite | 2022 |
Choline and phosphatidylcholine may maintain cognitive performance by multiple mechanisms.
Topics: Choline; Cognition; Dementia; Humans; Myocardial Ischemia; Phosphatidylcholines; Risk Factors | 2019 |
Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Choline; Cognitive Dysfunction; Dementia; Female; Humans | 2020 |
Special issue on advances and controversies in B vitamins and choline.
Topics: Aging; Choline; Dementia; Dietary Supplements; Humans; Risk Factors; Vascular Diseases; Vitamin B Co | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; De | 2014 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: early right hippocampal NAA/Cr loss in mildly impaired subjects.
Topics: Aged; Aspartic Acid; Choline; Creatine; Dementia; Female; Functional Laterality; Hippocampus; Humans | 2008 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De | 2009 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Posterior cingulate metabolic changes in frontotemporal lobar degeneration detected by magnetic resonance spectroscopy.
Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dementia; Di | 2004 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity.
Topics: Adult; Alcoholism; Aspartic Acid; Brain Mapping; Case-Control Studies; Cerebral Cortex; Choline; Com | 2005 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases.
Topics: Aged; Amnesia; Anomia; Aspartic Acid; Choline; Cognition Disorders; Creatine; Dementia; Female; Huma | 2008 |
Proton magnetic resonance spectroscopy detects a relative decrease of N-acetylaspartate in the hippocampus of patients with dementia with Lewy bodies.
Topics: Aged; Aspartic Acid; Chi-Square Distribution; Choline; Creatine; Dementia; Female; Hippocampus; Huma | 2008 |
Drugs for senile dementia.
Topics: Aged; Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Choline; Dementia; Dihydr | 1980 |
Cholinergic precursors in Alzheimer's disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans; Pilocarpine; Receptors, Muscarinic | 1982 |
Choline precursors and Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Choline; Dementia; Humans | 1982 |
Dementia in the aged.
Topics: Aged; Cerebral Infarction; Choline; Creutzfeldt-Jakob Syndrome; Dementia; Depressive Disorder; Diagn | 1982 |
Alzheimer's disease and Down's syndrome.
Topics: Acetylcholinesterase; Adult; Aged; Aging; Alzheimer Disease; Animals; Axons; Brain; Choline; Choline | 1982 |
Elevation of RBC glycine and choline levels in geriatric patients treated with lithium.
Topics: Aged; Alzheimer Disease; Choline; Cognition Disorders; Dementia; Erythrocytes; Female; Glycine; Huma | 1983 |
Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Cell Membrane; Choline; Cholinergic Fibers; | 1984 |
Relationship between nutrition and dementia in the elderly.
Topics: Acetylcholine; Aged; Aged, 80 and over; Aging; Aluminum; Choline; Cognition; Dementia; Folic Acid; H | 1983 |
[Dementia syndromes and epilepsy].
Topics: Adult; Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Epilepsy; Female; Humans; | 1984 |
Presynaptic cholinergic dysfunction in patients with dementia.
Topics: Acetylcholine; Adult; Aged; Alzheimer Disease; Carbon Radioisotopes; Cerebral Cortex; Choline; Choli | 1983 |
The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia.
Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Choline; Dementia; Dose-Response Relationship, Dru | 1983 |
[Citicoline activity in senile mental decay].
Topics: Aged; Choline; Cytidine Diphosphate Choline; Dementia; Drug Evaluation; Female; Humans; Injections, | 1983 |
Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blood Pressure; Choline; Dementia; Erythrocytes; Female; Humans; Hydrocorti | 1983 |
Lecithin does not affect EEG spectral analysis or P300 in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Evoked Potentials; Female; Human | 1982 |
Red-cell/plasma choline ratio in dementia.
Topics: Choline; Dementia; Erythrocytes; Humans; Plasma | 1982 |
Cerebrospinal fluid acetylcholine, choline, and senile dementia of the Alzheimer's type.
Topics: Acetylcholine; Aged; Alzheimer Disease; Choline; Dementia; Female; Humans; Male; Middle Aged | 1982 |
Clinical response to choline plus piracetam in senile dementia: relation to red-cell choline levels.
Topics: Choline; Dementia; Drug Therapy, Combination; Erythrocytes; Humans; Piracetam; Pyrrolidinones | 1981 |
Choline uptake in patients with Alzheimer pre-senile dementia.
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Choline; Dementia; Erythrocytes; Female; Humans; Male; M | 1981 |
Preventing senile dementia: hope for the future.
Topics: Aged; Choline; Dementia; Dihydroergotoxine; Female; Humans; Male; Memory; Middle Aged; Piracetam | 1981 |
Choline chloride fails to improve cognition of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Cognition; Dementia; Diarrhea; Dose-Response Relationship, Drug; D | 1981 |
Choline chloride in Alzheimer disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans | 1981 |
Choline, acetylcholine and dementia.
Topics: Acetylcholine; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Dementia; Humans | 1980 |
Acetylcholine and choline levels in post-mortem human brain tissue: preliminary observations in Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Choline; D | 1980 |
Neurochemical approaches to the treatment of senile dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferase; Dementia; Dys | 1980 |
Choline bitartrate treatment of Alzheimer-type dementias.
Topics: Aged; Alzheimer Disease; Behavior; Choline; Cognition; Dementia; Double-Blind Method; Female; Humans | 1980 |
Human memory and the effects of physostigmine and choline chloride [proceedings].
Topics: Adolescent; Adult; Aged; Choline; Dementia; Double-Blind Method; Humans; Memory; Middle Aged; Physos | 1980 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Role of increased cerebral myo-inositol in the dementia of Down syndrome.
Topics: Adolescent; Adult; Alzheimer Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creati | 1995 |
Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood-Brain Barrier; Brain | 1995 |
Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Cerebral Cortex; Choline; Dementia; Female; Hippocam | 1995 |
Proton MR spectroscopy of the brain in 14 patients with Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dementia; Energy Metabolism | 1995 |
[Experimental techniques for developing new drugs acting on dementia (4)--Aged rats].
Topics: Acetylcholinesterase; Aging; Animals; Choline; Choline O-Acetyltransferase; Dementia; Female; Male; | 1994 |
Alterations of selected enzymes of phospholipid metabolism in Alzheimer's disease brain tissue as compared to non-Alzheimer's demented controls.
Topics: Aged; Alzheimer Disease; Brain; Choline; Choline Kinase; Dementia; Humans; Phospholipids; Phosphoric | 1993 |
Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Choline; Cre | 2001 |
Clinical effects of choline in Alzheimer senile dementia.
Topics: Administration, Oral; Aged; Alzheimer Disease; Choline; Dementia; Drug Evaluation; Female; Humans; M | 1977 |
Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Dementia; gamma-Amin | 1977 |
Clinical effects of choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Female; Humans; Male | 1978 |
Possible biochemical basis of memory disorder in Alzheimer disease.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferas | 1978 |
Will drugs help patients with Alzheimer's disease?
Topics: Alzheimer Disease; Choline; Choline O-Acetyltransferase; Dementia; Humans | 1979 |
[Influence of choline on amnesia in Alzheimer's disease (author's transl)].
Topics: Aged; Alzheimer Disease; Amnesia; Choline; Dementia; Female; Humans; Learning; Male; Mental Recall; | 1979 |
The arteriovenous difference of choline across the brain of man.
Topics: Adult; Aged; Brain; Choline; Dementia; Female; Humans; Male; Middle Aged | 1975 |
Erythrocyte choline concentrations in psychiatric disorders.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Bipolar Disorder; Choline; Dementia; Depressi | 1991 |
Effect of the 'antidementia drug' pantoyl-GABA on high affinity transport of choline and on the contents of choline and acetylcholine in rat brain.
Topics: Acetylcholine; Animals; Biological Transport, Active; Brain; Choline; Dementia; gamma-Aminobutyric A | 1988 |
Red blood cell/plasma choline ratio in elderly depressed and demented patients.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Depressive Disorder; Electroencephalography; Erythrocyte | 1988 |
[Neuropsychological study of the senile brain during and after single and combined treatment with deanol and citicoline].
Topics: Aged; Choline; Cytidine Diphosphate Choline; Deanol; Dementia; Double-Blind Method; Drug Evaluation; | 1986 |