choline has been researched along with Dementia, Vascular in 18 studies
Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
| Excerpt | Relevance | Reference |
|---|---|---|
| "An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons." | 1.32 | Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. ( Chu, CB; Jia, JM; Jia, JP; Sun, YX; Xu, M; Yan, X; Zhou, WD, 2004) |
| "The level in patients with Parkinson's disease, where dementia develops in up to 40% of patients, was not elevated significantly compared to that in controls." | 1.32 | Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor. ( Aasly, J; Gårseth, M; Sonnewald, U; White, LR, 2004) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gasparovic, C | 1 |
| Prestopnik, J | 1 |
| Thompson, J | 1 |
| Taheri, S | 1 |
| Huisa, B | 1 |
| Schrader, R | 1 |
| Adair, JC | 1 |
| Rosenberg, GA | 2 |
| Liu, CL | 1 |
| Chen, H | 1 |
| Jiang, Y | 1 |
| Tu, PF | 1 |
| Zhong, M | 1 |
| Ma, JY | 1 |
| Ding, H | 1 |
| Zhang, WX | 1 |
| Jin, XM | 1 |
| Watanabe, T | 1 |
| Shiino, A | 1 |
| Akiguchi, I | 1 |
| Algin, O | 1 |
| Hakyemez, B | 1 |
| Parlak, M | 1 |
| Bender, B | 1 |
| Bornemann, A | 1 |
| Reimold, M | 1 |
| Ernemann, U | 1 |
| Horger, M | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Waldman, AD | 1 |
| Rai, GS | 1 |
| Marszał, E | 1 |
| Jamroz, E | 1 |
| Paprocka, J | 1 |
| Kluczewska, E | 1 |
| Sokół, M | 1 |
| Jia, JP | 1 |
| Jia, JM | 1 |
| Zhou, WD | 1 |
| Xu, M | 1 |
| Chu, CB | 1 |
| Yan, X | 1 |
| Sun, YX | 1 |
| White, LR | 1 |
| Gårseth, M | 1 |
| Aasly, J | 1 |
| Sonnewald, U | 1 |
| Kantarci, K | 1 |
| Petersen, RC | 1 |
| Boeve, BF | 1 |
| Knopman, DS | 1 |
| Tang-Wai, DF | 1 |
| O'Brien, PC | 1 |
| Weigand, SD | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Jack, CR | 1 |
| Ross, AJ | 1 |
| Sachdev, PS | 1 |
| Wen, W | 1 |
| Valenzuela, MJ | 1 |
| Brodaty, H | 1 |
| Constans, JM | 2 |
| Meyerhoff, DJ | 2 |
| Gerson, J | 1 |
| MacKay, S | 2 |
| Norman, D | 2 |
| Fein, G | 2 |
| Weiner, MW | 2 |
| Kattapong, VJ | 1 |
| Brooks, WM | 1 |
| Wesley, MH | 1 |
| Kodituwakku, PW | 1 |
| Tohgi, H | 1 |
| Abe, T | 1 |
| Kimura, M | 1 |
| Saheki, M | 1 |
| Takahashi, S | 1 |
| Kimura, S | 1 |
| Saito, H | 1 |
| Minami, M | 1 |
| Togashi, H | 1 |
| Nakamura, N | 1 |
| Nemoto, M | 1 |
| Parvez, HS | 1 |
| Palleschi, M | 1 |
| Capobianco, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
2 trials available for choline and Dementia, Vascular
| Article | Year |
|---|---|
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differenti | 2008 |
1H MRS in stroke patients with and without cognitive impairment.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; C | 2005 |
16 other studies available for choline and Dementia, Vascular
| Article | Year |
|---|---|
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn | 2013 |
[Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats].
Topics: Acetylcholine; Animals; Choline; Corpus Striatum; Dementia, Vascular; Glycosides; Hippocampus; Male; | 2013 |
Proton MR spectroscopy and white matter hyperintensities in idiopathic normal pressure hydrocephalus and other dementias.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differential; Female; | 2010 |
[Imaging findings in autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) - CADASIL - the most frequent familial stroke syndrome].
Topics: Aged; Brain; CADASIL; Choline; Chromosome Aberrations; Dementia, Vascular; Diffusion Magnetic Resona | 2012 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognition Disorders; Creatinine; Dementia, Vascular | 2003 |
Leukoencephalopathy with macrocephaly and mild clinical course.
Topics: Abnormalities, Multiple; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatinine; Dementi | 2004 |
Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Blood-Brain Barrier; Choline; Dementia, Vascular; Female; Hu | 2004 |
Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Case-Control Studi | 2004 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Brain Ischem | 1996 |
Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Dementia, Vascular; Diagnosis, Dif | 1996 |
Cerebrospinal fluid acetylcholine and choline in vascular dementia of Binswanger and multiple small infarct types as compared with Alzheimer-type dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Biomarkers; Choline; Cholinergic Agents; Dementia, Multi-Inf | 1996 |
Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Aged; Animals; Behavior, Animal; Brain; Brain Chemistry; Cerebral Infarction; Choline | 2000 |
[Pathological aging of the brain. Personal observations on the use of citicoline].
Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Choline; Chronic Disease; Cytidine Diphosphate C | 1988 |