choline has been researched along with Delayed Effects, Prenatal Exposure in 110 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-nine Cape Coloured (mixed ancestry) heavy drinkers in Cape Town, South Africa, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of either 2 g of choline or placebo from time of enrollment until delivery." | 9.27 | Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Herbert, JS; Hoyme, HE; Jacobson, JL; Jacobson, SW; Lewis, CE; Lindinger, NM; Meintjes, EM; Molteno, CD; Stanton, ME; Zeisel, SH, 2018) |
| " Regarding the well-known effects of choline on brain-derived neurotrophic factor (BDNF), the study examined the effects of choline on hippocampal BDNF gene expression in maternal hypothyroidism rats." | 8.31 | Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats. ( Aghazadeh, R; Bagheri, M; Derafshpour, L; Saboory, E; Sayyadi, H; Sheikhi, S, 2023) |
| "Our objectives were to examine whether fetal vulnerability to PAE-related growth restriction is modified by: 1) rate of gestational weight gain; or prenatal dietary intakes of 2) energy, 3) iron, or 4) choline." | 8.12 | Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Senekal, M, 2022) |
| "This study investigated the interaction of choline and FA in gestational diets on food intake, body weight, one-carbon metabolism, and hypothalamic gene expression in male Wistar rat offspring." | 8.02 | Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring. ( Anderson, GH; Bottiglieri, T; Caudill, MA; Hammoud, R; Kubant, R; Malysheva, OV; Pannia, E; Wasek, B, 2021) |
| " Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years." | 7.79 | Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013) |
| ") of saline (control) or kainic acid to induce seizures and were euthanized 16 days later." | 7.77 | Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. ( Blusztajn, JK; Glenn, MJ; Mellott, TJ; Tognoni, CM; Williams, CL; Wong-Goodrich, SJ, 2011) |
| "Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers." | 7.74 | Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. ( Berger-Sweeney, JE; Nag, N, 2007) |
| "Supplementation of maternal diet with the essential nutrient, choline, during the second half of pregnancy in rats causes long-lasting improvements in spatial memory in the offspring and protects them from the memory decline characteristic of old age." | 7.74 | Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. ( Blusztajn, JK; Kowall, NW; Lopez-Coviella, I; Mellott, TJ, 2007) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 7.72 | Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003) |
| "Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J." | 7.71 | Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Yang, Y, 2002) |
| "Choline is a semi-essential nutrient involved in lipid and one-carbon metabolism that is compromised during MAFLD progression." | 5.91 | Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes. ( Bretter, R; Caviglia, JM; Jiang, X; Johnson, CH; Kadam, I; Korsmo, HW; Reaz, A; Saxena, A, 2023) |
| "Choline is a key nutrient in fetal brain development." | 5.62 | Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. ( Balser, M; D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Walker, VK, 2021) |
| " Maternal nutritional status may be an important factor in determining the extent to which PAE impacts pregnancy outcomes, particularly the dietary micronutrients folate and choline because they provide methyl groups for DNA methylation via one carbon metabolism." | 5.41 | The role of maternal choline, folate and one-carbon metabolism in mediating the impact of prenatal alcohol exposure on placental and fetal development. ( Cuffe, JSM; Moritz, KM; Steane, SE, 2023) |
| "Choline is a selective agonist for the alpha7 nicotinic receptor which appears in development before acetylcholine is present." | 5.35 | Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. ( Adams, CE; Kisley, MA; Mellott, TJ; Robbins, E; Stevens, KE, 2008) |
| "Sixty-nine Cape Coloured (mixed ancestry) heavy drinkers in Cape Town, South Africa, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of either 2 g of choline or placebo from time of enrollment until delivery." | 5.27 | Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Herbert, JS; Hoyme, HE; Jacobson, JL; Jacobson, SW; Lewis, CE; Lindinger, NM; Meintjes, EM; Molteno, CD; Stanton, ME; Zeisel, SH, 2018) |
| "This study demonstrated that a choline supplementation program with very heavy drinkers during pregnancy is feasible even among highly disadvantaged, poorly educated women." | 5.27 | Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Lindinger, NM; Meintjes, EM; Molteno, CD; Senekal, MS; Zeisel, SH, 2018) |
| " Regarding the well-known effects of choline on brain-derived neurotrophic factor (BDNF), the study examined the effects of choline on hippocampal BDNF gene expression in maternal hypothyroidism rats." | 4.31 | Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats. ( Aghazadeh, R; Bagheri, M; Derafshpour, L; Saboory, E; Sayyadi, H; Sheikhi, S, 2023) |
| "Our objectives were to examine whether fetal vulnerability to PAE-related growth restriction is modified by: 1) rate of gestational weight gain; or prenatal dietary intakes of 2) energy, 3) iron, or 4) choline." | 4.12 | Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Senekal, M, 2022) |
| "Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid accounts for many of these effects in male, but not in female, offspring." | 4.02 | Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring. ( Aardema, NDJ; Bunnell, ML; Cho, CE; Hintze, KJ; Mjaaseth, UN; Norris, JC; Ward, RE, 2021) |
| "Maternal infection, depression, obesity, and other factors associated with inflammation were assessed at 16 weeks gestation, along with maternal C-reactive protein (CRP), cytokines, and serum choline." | 4.02 | Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. ( D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Wyrwa, A, 2021) |
| "This study investigated the interaction of choline and FA in gestational diets on food intake, body weight, one-carbon metabolism, and hypothalamic gene expression in male Wistar rat offspring." | 4.02 | Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring. ( Anderson, GH; Bottiglieri, T; Caudill, MA; Hammoud, R; Kubant, R; Malysheva, OV; Pannia, E; Wasek, B, 2021) |
| "Choline content of diets that are consumed by rats during pregnancy affects the later-life phenotype of offspring, associated with altered in utero programing of hypothalamic food intake regulation." | 3.96 | Maternal Choline Intake Programs Hypothalamic Energy Regulation and Later-Life Phenotype of Male Wistar Rat Offspring. ( Anderson, GH; Caudill, MA; Chatterjee, D; Hammoud, R; Ho, M; Kubant, R; Liao, CS; Malysheva, OV; Pannia, E; Pausova, Z; Yang, NV, 2020) |
| " Women who differed in prenatal alcohol use were recruited during pregnancy and assigned to a group (No study-provided supplements, multivitamin/mineral supplement, or multivitamin/mineral supplement plus choline supplement)." | 3.81 | The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. ( Chambers, CD; Coles, CD; Jones, KL; Kable, JA; Keen, CL; Kulikovsky, Y; Pedersen, TL; Uriu-Adams, JY; Wertelecki, W; Yevtushok, L, 2015) |
| "Maternal choline supplementation (MCS) induces lifelong cognitive benefits in the Ts65Dn mouse, a trisomic mouse model of Down syndrome and Alzheimer's disease." | 3.80 | Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice. ( Alldred, MJ; Caudill, MA; Ginsberg, SD; Powers, B; Saltzman, A; Strupp, BJ; Yan, J, 2014) |
| " Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years." | 3.79 | Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013) |
| " We examined the associations of maternal intake of folate, vitamin B12, choline, betaine and methionine during the first and second trimesters of pregnancy, with tests of cognitive performance in the offspring at 3 years of age using data from 1210 participants in Project Viva, a prospective pre-birth cohort study in Massachusetts." | 3.78 | Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. ( Gillman, MW; Oken, E; Rifas-Shiman, SL; Villamor, E, 2012) |
| ") of saline (control) or kainic acid to induce seizures and were euthanized 16 days later." | 3.77 | Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. ( Blusztajn, JK; Glenn, MJ; Mellott, TJ; Tognoni, CM; Williams, CL; Wong-Goodrich, SJ, 2011) |
| "Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is accompanied by behavioral and neuropathological abnormalities and decreases in brain cholinergic markers." | 3.74 | Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. ( Berger-Sweeney, JE; Nag, N, 2007) |
| "Supplementation of maternal diet with the essential nutrient, choline, during the second half of pregnancy in rats causes long-lasting improvements in spatial memory in the offspring and protects them from the memory decline characteristic of old age." | 3.74 | Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. ( Blusztajn, JK; Kowall, NW; Lopez-Coviella, I; Mellott, TJ, 2007) |
| " We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation." | 3.74 | A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats. ( Os'kina, IN; Plyusnina, IZ; Prasolova, LA; Shchepina, OA; Trut, LN, 2007) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 3.72 | Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003) |
| "Female Sprague-Dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age." | 3.71 | Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. ( Loy, R; Sandstrom, NJ; Williams, CL, 2002) |
| "Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J." | 3.71 | Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Yang, Y, 2002) |
| "Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring." | 3.70 | Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. ( Jones, JP; Meck, WH; Swartzwelder, HS; Williams, CL; Wilson, WA, 1999) |
| "FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windows are emerging." | 2.94 | Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Lindgren, C; Miller, NC; Radke, JP; Sandness, KE; Wozniak, JR; Zeisel, SH, 2020) |
| "There are no biological treatments for fetal alcohol spectrum disorders (FASDs), lifelong conditions associated with physical anomalies, brain damage, and neurocognitive abnormalities." | 2.78 | Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Hoecker, HL; Kroupina, MG; Miller, NC; Wozniak, JR; Zeisel, SH, 2013) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide." | 2.66 | One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020) |
| "Choline interventions were administered at different times relative to alcohol exposure, impacting on their success to prevent deficits for specific outcomes." | 2.58 | Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies. ( Akison, LK; Boyd, RN; Kuo, J; Moritz, KM; Reid, N, 2018) |
| "Choline is a semi-essential nutrient involved in lipid and one-carbon metabolism that is compromised during MAFLD progression." | 1.91 | Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes. ( Bretter, R; Caviglia, JM; Jiang, X; Johnson, CH; Kadam, I; Korsmo, HW; Reaz, A; Saxena, A, 2023) |
| "Individuals with fetal alcohol spectrum disorders (FASD) incur enduring brain damage and neurodevelopmental impairments from prenatal alcohol exposure (PAE)." | 1.72 | The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent. ( Carugati, M; Cudd, TA; Goodlett, CR; Washburn, SE, 2022) |
| "Choline is a key nutrient in fetal brain development." | 1.62 | Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. ( Balser, M; D'Alessandro, A; Freedman, R; Hoffman, MC; Hunter, SK; Law, AJ; Noonan, K; Walker, VK, 2021) |
| "Choline is an essential nutrient under evaluation as a cognitive enhancing treatment for fetal alcohol spectrum disorders (FASD) in clinical trials." | 1.62 | Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. ( Christie, BR; Fontaine, CJ; Grafe, EL; Thomas, JD, 2021) |
| "The cholinergic system plays a crucial role in learning and memory processes." | 1.56 | Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats. ( Hill, E; Jiang, L; Mooney, SM; Tang, S; Waddell, J; Xu, S, 2020) |
| "Choline (5ppm) was given to half the nursing dams and weanlings in each group from P11-P30." | 1.48 | Beneficial effects of postnatal choline supplementation on long-Term neurocognitive deficit resulting from fetal-Neonatal iron deficiency. ( Georgieff, MK; Gewirtz, JC; Kennedy, BC; Kohli, M; Maertens, JJ; Tran, PV, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis." | 1.46 | Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. ( Alfaro, M; Chintapalli, SV; Kang, P; Shankar, K; Thakali, KM; Wankhade, UD; Zhong, Y, 2017) |
| "Choline (5 g/kg) was given to half the pregnant dams in each group from G11 to G18." | 1.43 | Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus. ( Georgieff, MK; Gewirtz, JC; Kennedy, BC; Pisansky, MT; Simmons, RA; Tran, PV; Won, KJ, 2016) |
| "Choline treatment failed to attenuate alcohol-related overactivity in the open field and deficits in Morris water maze performance." | 1.43 | Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent. ( Schneider, RD; Thomas, JD, 2016) |
| "Choline is an essential nutrient, but many diets in the USA are choline deficient." | 1.42 | Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure. ( Bearer, CF; He, M; Mooney, SM; Tang, N; Wellmann, KA, 2015) |
| "Lumbosacral spina bifida is a common debilitating birth defect whose multiple causes are poorly understood." | 1.38 | Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. ( Capecchi, MR; Gahring, LC; Rogers, SW; Tvrdik, P, 2012) |
| "Choline has been shown to have direct BP-reducing effects in humans and animals." | 1.38 | Increased systolic blood pressure in rat offspring following a maternal low-protein diet is normalized by maternal dietary choline supplementation. ( Bai, SY; Briggs, DI; Vickers, MH, 2012) |
| "Colitis was induced by dextran sulfate sodium." | 1.37 | Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. ( Dowd, SE; Harris, RA; Kellermayer, R; Schaible, TD; Smith, CW, 2011) |
| "Choline is an essential nutrient that influences brain and behavioral development." | 1.36 | Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. ( Dominguez, HD; Idrus, NM; Monk, BR; Thomas, JD, 2010) |
| "Choline is a selective agonist for the alpha7 nicotinic receptor which appears in development before acetylcholine is present." | 1.35 | Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. ( Adams, CE; Kisley, MA; Mellott, TJ; Robbins, E; Stevens, KE, 2008) |
| "Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects." | 1.35 | Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. ( Blusztajn, JK; Mellott, TJ; Napoli, I, 2008) |
| "Choline is an essential nutrient that serves as a donor of metabolic methyl groups used during gestation to establish the epigenetic DNA methylation patterns that modulate tissue-specific gene expression." | 1.35 | Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. ( Blusztajn, JK; Davison, JM; Kovacheva, VP; Mellott, TJ; O'Brien, MJ; Rogers, AE; Yang, S, 2009) |
| "Three of them had fetal alcohol syndrome (FAS), 3 had partial FAS (PFAS), and 4 had alcohol-related neurobehavioral disorder (ARND)." | 1.33 | Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders. ( Autti-Rämö, I; Fagerlund, A; Heikkinen, S; Korkman, M; Kuusi, T; Lundbom, N; Riley, EP; Timonen, M, 2006) |
| "Choline is an essential nutrient for animals and humans." | 1.32 | Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. ( Blusztajn, JK; Meck, WH; Mellott, TJ; Williams, CL, 2004) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.64) | 18.7374 |
| 1990's | 7 (6.36) | 18.2507 |
| 2000's | 33 (30.00) | 29.6817 |
| 2010's | 38 (34.55) | 24.3611 |
| 2020's | 28 (25.45) | 2.80 |
| Authors | Studies |
|---|---|
| Grafe, EL | 2 |
| Fontaine, CJ | 1 |
| Thomas, JD | 9 |
| Christie, BR | 2 |
| Kwan, STC | 1 |
| Ricketts, DK | 1 |
| Presswood, BH | 1 |
| Smith, SM | 1 |
| Mooney, SM | 3 |
| Mjaaseth, UN | 1 |
| Norris, JC | 1 |
| Aardema, NDJ | 1 |
| Bunnell, ML | 1 |
| Ward, RE | 1 |
| Hintze, KJ | 1 |
| Cho, CE | 1 |
| Liu, SX | 2 |
| Barks, AK | 1 |
| Lunos, S | 1 |
| Gewirtz, JC | 4 |
| Georgieff, MK | 9 |
| Tran, PV | 6 |
| Carugati, M | 1 |
| Goodlett, CR | 2 |
| Cudd, TA | 2 |
| Washburn, SE | 2 |
| Carter, RC | 3 |
| Senekal, M | 1 |
| Duggan, CP | 3 |
| Dodge, NC | 3 |
| Meintjes, EM | 3 |
| Molteno, CD | 3 |
| Jacobson, JL | 3 |
| Jacobson, SW | 3 |
| Steane, SE | 2 |
| Kumar, V | 1 |
| Cuffe, JSM | 2 |
| Moritz, KM | 3 |
| Akison, LK | 2 |
| Wade, MMM | 1 |
| Hodson, CE | 1 |
| Baker, JA | 1 |
| Breit, KR | 1 |
| Bodnar, TS | 1 |
| Weinberg, J | 1 |
| Sheikhi, S | 1 |
| Derafshpour, L | 1 |
| Aghazadeh, R | 1 |
| Sayyadi, H | 1 |
| Saboory, E | 1 |
| Bagheri, M | 1 |
| Korsmo, HW | 2 |
| Kadam, I | 1 |
| Reaz, A | 1 |
| Bretter, R | 1 |
| Saxena, A | 2 |
| Johnson, CH | 1 |
| Caviglia, JM | 1 |
| Jiang, X | 2 |
| Fredrickson, TK | 1 |
| Calixto Mancipe, N | 1 |
| Serwatka, CA | 1 |
| Griebel-Thompson, AK | 1 |
| Eiden, RD | 1 |
| Kong, KL | 1 |
| Hasken, JM | 1 |
| de Vries, MM | 1 |
| Marais, AS | 1 |
| Kalberg, WO | 1 |
| Buckley, D | 1 |
| Parry, CDH | 1 |
| Seedat, S | 1 |
| May, PA | 1 |
| Pull, K | 1 |
| Folk, R | 1 |
| Kang, J | 1 |
| Jackson, S | 1 |
| Gusek, B | 1 |
| Esfandiarei, M | 1 |
| Jadavji, NM | 1 |
| Hunter, SK | 6 |
| Hoffman, MC | 6 |
| D'Alessandro, A | 6 |
| Noonan, K | 6 |
| Wyrwa, A | 5 |
| Freedman, R | 7 |
| Law, AJ | 5 |
| Radziejewska, A | 1 |
| Muzsik, A | 1 |
| Milagro, FI | 1 |
| Martínez, JA | 1 |
| Chmurzynska, A | 1 |
| Edwards, K | 1 |
| Dave, B | 1 |
| Jack-Roberts, C | 1 |
| Yu, H | 1 |
| Salvador, M | 1 |
| Dembitzer, M | 1 |
| Phagoora, J | 1 |
| Hammoud, R | 2 |
| Pannia, E | 2 |
| Kubant, R | 2 |
| Liao, CS | 1 |
| Ho, M | 1 |
| Yang, NV | 1 |
| Chatterjee, D | 1 |
| Caudill, MA | 3 |
| Malysheva, OV | 2 |
| Pausova, Z | 1 |
| Anderson, GH | 2 |
| Wozniak, JR | 3 |
| Fink, BA | 2 |
| Fuglestad, AJ | 2 |
| Eckerle, JK | 3 |
| Boys, CJ | 2 |
| Sandness, KE | 1 |
| Radke, JP | 1 |
| Miller, NC | 2 |
| Lindgren, C | 1 |
| Brearley, AM | 2 |
| Zeisel, SH | 7 |
| McCarthy, L | 1 |
| Christians, U | 2 |
| Nakimuli-Mpungu, E | 1 |
| Waddell, J | 1 |
| Hill, E | 1 |
| Tang, S | 1 |
| Jiang, L | 1 |
| Xu, S | 1 |
| Wasek, B | 1 |
| Bottiglieri, T | 1 |
| Walker, VK | 1 |
| Balser, M | 1 |
| Wankhade, UD | 1 |
| Zhong, Y | 1 |
| Kang, P | 1 |
| Alfaro, M | 1 |
| Chintapalli, SV | 1 |
| Thakali, KM | 1 |
| Shankar, K | 1 |
| Nickerson, CA | 1 |
| Brown, AL | 1 |
| Yu, W | 1 |
| Chun, Y | 1 |
| Glenn, MJ | 6 |
| Kennedy, BC | 4 |
| Kohli, M | 1 |
| Maertens, JJ | 1 |
| Senekal, MS | 1 |
| Lindinger, NM | 2 |
| Stanton, ME | 1 |
| Herbert, JS | 1 |
| Lewis, CE | 1 |
| Hoyme, HE | 1 |
| Kuo, J | 1 |
| Reid, N | 1 |
| Boyd, RN | 1 |
| Wagner, BD | 1 |
| Sarkar, DK | 2 |
| Gangisetty, O | 1 |
| Foroud, TM | 1 |
| Wetherill, L | 1 |
| Wertelecki, W | 2 |
| Chambers, CD | 3 |
| Riley, E | 1 |
| Zymak-Zakutnya, N | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure[NCT01149538] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235] | 653 participants (Anticipated) | Interventional | 2021-02-12 | Recruiting | |||
| Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders[NCT01911299] | Phase 2 | 55 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)[NCT03269110] | 2,578 participants (Anticipated) | Observational | 2017-07-01 | Enrolling by invitation | |||
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Elicited Imitation (EI) paradigm (P.J. Bauer, 1989, Dev. Psychology) was used to measure memory in the participants at baseline, 6 months, and 9 months. The measures were items recalled after a delay (delayed items) and pairs of items recalled after a delay (delayed pairs). The sample was split by age in the analysis (young vs. old) as reflected in the outcome data. Outcome data measures included here are the slopes of the regression lines reflecting change over the three timepoints, controlling for immediate memory performance on the EI task.The slopes are given, as opposed to the raw scores, because these were the values used in the growth curve analyses. Details of these analyses are included in Wozniak et al. (2015) AJCN, doi:10.3945/ajcn.114.099168. NOTE that the means presented below represent the simple slopes that estimate the change in task performance (% of items correct) per 6-month unit of time. To estimate change in task performance over 9 months, multiply by 1.5. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Slope (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Delayed-Items-Young | Delayed-Items-Old | Delayed-Pairs-Young | Delayed-Pairs-Old | Immed-Items-Young | Immed-Items-Old | Immed-Pairs-Young | Immed-Pairs-Old | |
| Choline Bitartrate | 14.24 | -.71 | 18.97 | 2.69 | 8.48 | 2.59 | 8.75 | 11.46 |
| Placebo | 4.43 | 4.23 | 10.39 | 7.79 | 13.72 | 3.89 | 20.01 | 5.50 |
Evoked Response Potential - negative component latency data are included. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Milliseconds (Mean) | ||
|---|---|---|---|
| Frontal Neg Component Latency at baseline | Frontal Neg Component at 6 months | Frontal Neg Component at 9 months | |
| Choline Bitartrate | 2.23 | 32.45 | -4.00 |
| Placebo | 5.35 | -4.28 | -3.03 |
Evoked response potentials were measured for the memory task. Frontal positive slow-wave potential negative component amplitude data are included. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Mircovolts (Mean) | |||||
|---|---|---|---|---|---|---|
| Frontal Positive Slow Wave (PSW) - Baseline | Frontal Positive Slow Wave (PSW) - 6 months | Frontal Positive Slow Wave (PSW) - 9 months | Frontal Neg Component Amplitude - Baseline | Frontal Neg Component Amplitude - 6 months | Frontal Neg Component Amplitude - 9 months | |
| Choline Bitartrate | -2.05 | -1.04 | -0.26 | -2.53 | 1.22 | 0.35 |
| Placebo | 0.57 | -1.03 | -1.41 | 0.62 | -0.84 | -1.37 |
The Mullen Scales of Early Learning is a measure of global cognitive development and is a primary outcome measure. The Early Learning Composite is the total score for this measure. It is a scaled score with a mean of 100 and a standard deviation of 15 (higher scores indicate better global cognitive status; average range is 85-115; Impaired range is 70 or below; full range is typically 50 - 150, although minimum and maximum scores are dependent on age). See the Mullen Scales reference manual for more psychometric details. (NCT01149538)
Timeframe: Baseline and 9 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 9-month follow-up | |
| Choline Bitartrate | 83.2 | 87.1 |
| Placebo | 84.3 | 89.6 |
Side effects of choline bitartrate will be monitored by the study physician and the P.I. with physical examinations and telephone contact. (NCT01149538)
Timeframe: Baseline, 6 months, & 9 months
| Intervention | participants (Number) | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline energy level problems | 6 month energy level problems | 9 months energy level problems | Baseline pain | 6 month pain | 9 month pain | Baseline skin problems | 6 month skin problems | 9 month skin problems | Baseline Ear Nose Throat problems | 6 month Ear Nose Throat problems | 9 month Ear Nose Throat problems | Baseline headaches/dizziness | 6 month headaches/dizziness | 9 month headaches/dizziness | Baseline vision problems | 6 month vision problems | 9 month vision problems | Baseline cardiovascular | 6 month cardiovascular | 9 month cardiovascular | Baseline respiratory problems | 6 month respiratory problems | 9 month respiratory problems | Baseline gastrointestinal problems | 6 month gastrointestinal problems | 9 month gastrointestinal problems | Baseline genitourinary problems | 6 month genitourinary problems | 9 month genitourinary problems | Baseline musculoskeletal problems | 6 month musculoskeletal problems | 9 month musculoskeletal problems | 6 month neurologic/psychiatric problems | 9 month neurologic/psychiatric problems | Baseline neurologic/psychiatric problems | Baseline allergic problems | 6 month allergic problems | 9 month allergic problems | |
| Choline Bitartrate | 8 | 8 | 8 | 3 | 3 | 3 | 6 | 6 | 6 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 0 | 0 | 1 | 1 | 1 | 6 | 6 | 6 | 18 | 18 | 18 | 4 | 4 | 4 | 0 | 0 | 0 | 11 | 11 | 11 | 2 | 0 | 0 |
| Placebo | 10 | 9 | 9 | 4 | 4 | 4 | 6 | 5 | 5 | 0 | 0 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 6 | 6 | 6 | 14 | 11 | 11 | 9 | 8 | 8 | 1 | 1 | 1 | 9 | 9 | 9 | 3 | 3 | 3 |
6 reviews available for choline and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
The role of maternal choline, folate and one-carbon metabolism in mediating the impact of prenatal alcohol exposure on placental and fetal development.
Topics: Carbon; Choline; Female; Fetal Development; Folic Acid; Humans; Maternal-Fetal Exchange; Micronutrie | 2023 |
Nutrient Supplementation during the Prenatal Period in Substance-Using Mothers: A Narrative Review of the Effects on Offspring Development.
Topics: Animals; Choline; Dietary Supplements; Ethanol; Female; Humans; Mothers; Nicotine; Pregnancy; Prenat | 2023 |
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi | 2020 |
Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Choline; Clinical Trials as Topic; Cognition; Cognitive | 2018 |
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan.
Topics: Aging; Animals; Attention; Behavior, Animal; Choline; Cognition; Dietary Supplements; Embryonic and | 2003 |
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring.
Topics: Animals; Behavior, Animal; Brain; Cell Size; Choline; Choline Deficiency; Cognition; Critical Period | 2006 |
6 trials available for choline and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
Topics: Child, Preschool; Choline; Cognition; Double-Blind Method; Female; Fetal Alcohol Spectrum Disorders; | 2020 |
Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Alcohol Drinking; Choline; Dietary Supplements; Double-Blind Method; Feasibility Studies; Female; Fe | 2018 |
Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Adult; Alcohol Drinking; Birth Weight; Blinking; Choline; Cognition; Dietary Supplements; Double-Bli | 2018 |
Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Depressants; Child; Child, Preschool | 2019 |
Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.
Topics: Alcohol Drinking; Child, Preschool; Choline; Dietary Supplements; Double-Blind Method; Female; Fetal | 2013 |
Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.
Topics: Child; Child, Preschool; Choline; Cognition; Dietary Supplements; Dose-Response Relationship, Drug; | 2016 |
98 other studies available for choline and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus.
Topics: Animals; Central Nervous System Depressants; Choline; Dentate Gyrus; Disease Models, Animal; Ethanol | 2021 |
Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol-exposed fetal organs.
Topics: Animals; Animals, Newborn; Choline; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders | 2021 |
Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Choline; Diet; Female; Folic | 2021 |
Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate
Topics: Animals; Brain-Derived Neurotrophic Factor; Choline; Dietary Supplements; DNA-Binding Proteins; Epig | 2021 |
The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent.
Topics: Animals; Choline; Dietary Supplements; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disord | 2022 |
Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort.
Topics: Alcohol Drinking; Animals; Birth Cohort; Child; Choline; Diet; Ethanol; Female; Fetal Alcohol Spectr | 2022 |
Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure.
Topics: Animals; Carbon; Choline; Dietary Supplements; Ethanol; Female; Humans; Placenta; Pregnancy; Prenata | 2022 |
Postnatal Choline Supplementation Rescues Deficits in Synaptic Plasticity Following Prenatal Ethanol Exposure.
Topics: Animals; Choline; Dietary Supplements; Ethanol; Female; Humans; Male; Neuronal Plasticity; Pregnancy | 2022 |
Choline Supplementation Modifies the Effects of Developmental Alcohol Exposure on Immune Responses in Adult Rats.
Topics: Animals; Animals, Newborn; Choline; Cytokines; Dietary Supplements; Ethanol; Female; Hippocampus; Im | 2022 |
Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Choline; Dietary Supplements; Female; Gene Expression; H | 2023 |
Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes.
Topics: Animals; Choline; Diet, High-Fat; Dietary Supplements; Female; Humans; Lipidomics; Liver; Male; Mate | 2023 |
Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome.
Topics: Animals; Animals, Newborn; Choline; Female; Hippocampus; Humans; Iron; Iron Deficiencies; Male; Preg | 2023 |
Maternal dietary intake among alcohol-exposed pregnancies is linked to early infant physical outcomes in South Africa.
Topics: Calcium; Choline; Diet; Eating; Ethanol; Fatty Acids; Female; Fetal Alcohol Spectrum Disorders; Foli | 2023 |
Impact of maternal dietary folic acid or choline dietary deficiencies on vascular function in young and middle-aged female mouse offspring after ischemic stroke.
Topics: Animals; Carbon; Choline; Diet; Female; Folic Acid; Humans; Ischemic Stroke; Maternal Nutritional Ph | 2023 |
Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development.
Topics: Brain; C-Reactive Protein; Choline; Female; Fetal Development; Fetus; Gestational Age; Humans; Infan | 2021 |
Prenatal Choline Supplementation during High-Fat Feeding Improves Long-Term Blood Glucose Control in Male Mouse Offspring.
Topics: Adiposity; Animals; Blood Glucose; Choline; Diet, High-Fat; Dietary Supplements; Female; Glucose Int | 2020 |
Maternal Choline Intake Programs Hypothalamic Energy Regulation and Later-Life Phenotype of Male Wistar Rat Offspring.
Topics: Animals; Body Weight; Choline; Eating; Energy Metabolism; Female; Hypothalamus; Lactation; Male; Neu | 2020 |
Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness.
Topics: Adult; Black or African American; Choline; Female; Gestational Age; Humans; Infant, Newborn; Mental | 2021 |
Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol | 2020 |
Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age.
Topics: Cannabis; Child; Child Development; Child, Preschool; Choline; Female; Fetal Development; Hallucinog | 2022 |
Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Appetite Regulation; Body Wei | 2021 |
Editor's Note to: Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness.
Topics: Black or African American; Choline; Female; Gestational Age; Humans; Mental Disorders; Pregnancy; Pr | 2021 |
Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV.
Topics: Child, Preschool; Choline; Female; Humans; Inflammation; Intelligence; Male; Mothers; Pregnancy; Pre | 2021 |
Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; DNA Methylation; Epige | 2017 |
Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats.
Topics: Aging; Animals; Choline; Dizocilpine Maleate; Doublecortin Protein; Female; Hippocampus; Male; Memor | 2017 |
Beneficial effects of postnatal choline supplementation on long-Term neurocognitive deficit resulting from fetal-Neonatal iron deficiency.
Topics: Anemia, Iron-Deficiency; Animals; Animals, Newborn; Choline; Dietary Supplements; Female; Hippocampu | 2018 |
Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development.
Topics: Adult; Brain; C-Reactive Protein; Choline; Cross-Sectional Studies; Female; Fetal Development; Human | 2019 |
Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring.
Topics: Adult; Brain; Choline; Female; Fetal Development; Gestational Age; Humans; Infant; Infant, Newborn; | 2020 |
Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing POMC neurons of the hypothalamus.
Topics: Animals; beta-Endorphin; Choline; Dietary Supplements; DNA Methylation; Female; Histones; Hypothalam | 2013 |
Choline intake during pregnancy and child cognition at age 7 years.
Topics: Adult; Betaine; Child; Child Development; Choline; Cognition; Dietary Supplements; Female; Folic Aci | 2013 |
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Choline; Disease Models, Animal; Doublecortin D | 2013 |
Audiogenic seizure proneness after methyl-enriched diet in ontogeny.
Topics: Animals; Betaine; Choline; Diet; DNA Methylation; Epilepsy, Reflex; Female; Methionine; Pregnancy; P | 2014 |
Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors.
Topics: Animals; Anxiety Disorders; Body Weight; Choline; Dietary Supplements; Exploratory Behavior; Female; | 2014 |
Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice.
Topics: Animals; Choline; Dietary Supplements; Docosahexaenoic Acids; Down Syndrome; Female; Lipid Metabolis | 2014 |
The effect of hypoxia-induced intrauterine growth restriction on renal artery function.
Topics: Animals; Choline; Female; Fetal Growth Retardation; Hypoxia; Male; Nitric Oxide; Phenylephrine; Preg | 2012 |
Increased systolic blood pressure in rat offspring following a maternal low-protein diet is normalized by maternal dietary choline supplementation.
Topics: Animals; Blood Pressure; Body Weight; Choline; Diet, Protein-Restricted; Dietary Supplements; Female | 2012 |
Prenatal choline supplementation ameliorates the long-term neurobehavioral effects of fetal-neonatal iron deficiency in rats.
Topics: Animals; Animals, Newborn; Choline; Dietary Supplements; Female; Gene Expression Regulation; Hematoc | 2014 |
Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus.
Topics: Age Factors; Animals; Binding Sites; Brain-Derived Neurotrophic Factor; Choline; Chromatin Assembly | 2015 |
Vascular effects of aerobic exercise training in rat adult offspring exposed to hypoxia-induced intrauterine growth restriction.
Topics: Animals; Choline; Endothelium, Vascular; Female; Fetal Growth Retardation; Hypoxia; Male; Mesenteric | 2015 |
The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Autistic Disorder; Behavior, Animal; Choline; Dise | 2015 |
Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Central Nervous System Depressants; Ch | 2015 |
The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants.
Topics: Adult; Central Nervous System Depressants; Choline; Dietary Supplements; Ethanol; Female; Fetal Alco | 2015 |
Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus.
Topics: Animals; Animals, Newborn; Behavior, Animal; Choline; Dietary Supplements; Female; Fetus; Gene Expre | 2016 |
Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Male; Maze Le | 2016 |
Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs.
Topics: Age Factors; Animals; Binge Drinking; Brain; Choline; Disease Models, Animal; Female; Male; Neuropro | 2016 |
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Bungarotoxins; Choline; Choline Deficiency; Evoked | 2008 |
Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration.
Topics: Age Factors; Alcohols; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weigh | 2008 |
Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; C | 2008 |
Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex.
Topics: Acetylcholine; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Choline; Female; Fronta | 2008 |
Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Carcinogens; Choline; Choline Deficiency; | 2009 |
Prenatal choline availability alters the context sensitivity of Pavlovian conditioning in adult rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Association Learning; Choline; Choline Deficiency; | 2008 |
[Methyl-containing diet of mothers affects the AGOUTI gene expression in the offspring of rats with various behavioral types].
Topics: Aggression; Agouti Signaling Protein; Animals; Behavior, Animal; Betaine; Choline; Dietary Supplemen | 2009 |
Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood.
Topics: Animals; Choline; Female; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Hum | 2011 |
Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome.
Topics: Aging; Animals; Attention; Choline; Cognition; Dietary Supplements; Disease Models, Animal; Down Syn | 2010 |
Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Bulimia; Choline; Dietary Supplements; Eth | 2010 |
Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study.
Topics: Arachidonic Acid; Child Development; Child Nutritional Physiological Phenomena; Child, Preschool; Ch | 2011 |
Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes.
Topics: Animals; Bacteria; Betaine; Choline; Colitis; Dietary Supplements; Disease Susceptibility; DNA Methy | 2011 |
Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Disease Susceptibility; Female; Hippocampus; Kain | 2011 |
Altered placental methyl donor transport in the dexamethasone programmed rat.
Topics: Animals; Biological Transport; Choline; Dexamethasone; DNA Methylation; Embryonic Development; Epist | 2012 |
The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt.
Topics: Acetylcholine; Animals; Animals, Newborn; Behavior, Animal; Choline; Dietary Supplements; Ethanol; F | 2012 |
Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Lineage; Choline; Female; Homologous Recombin | 2012 |
Maternal intake of methyl-donor nutrients and child cognition at 3 years of age.
Topics: Adult; Betaine; Child Development; Child, Preschool; Choline; Cognition; Cohort Studies; Diet; DNA M | 2012 |
Postnatal choline levels mediate cognitive deficits in a rat model of schizophrenia.
Topics: Animals; Choline; Choline Deficiency; Cognition Disorders; Disease Models, Animal; Dizocilpine Malea | 2012 |
Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats.
Topics: Aging; Animals; Cell Size; Choline; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Male; Me | 2002 |
Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Choline; Choline Deficiency; Diet; Dizocilpine Maleate; | 2003 |
Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus.
Topics: Aging; Animals; Calbindin 2; Choline; Choline Deficiency; Embryonic and Fetal Development; Female; G | 2003 |
Dietary prenatal choline supplementation alters postnatal hippocampal structure and function.
Topics: Action Potentials; Animals; Animals, Newborn; Cell Count; Cell Size; Choline; Dietary Supplements; E | 2004 |
Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
Topics: Animals; Choline; Choline Deficiency; Cues; Cyclic AMP Response Element-Binding Protein; Female; Glu | 2004 |
Sex-related differences in effect of ethanol administration and folic acid supplementation on pancreatic amylase in rats.
Topics: Amylases; Animals; Body Weight; Central Nervous System Depressants; Choline; Dietary Supplements; Et | 2004 |
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys.
Topics: Adenylyl Cyclases; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Brain; Choline; DNA; Female; He | 2005 |
Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Central Nervous System Depressants; C | 2006 |
Choline supplementation following third-trimester-equivalent alcohol exposure attenuates behavioral alterations in rats.
Topics: Alcohols; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Choline; Dose-Response Relations | 2007 |
Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome.
Topics: Acetylcholine; Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Brain; Choline; Di | 2007 |
Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Choline; Choline Deficiency; Female; G | 2007 |
Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Choline; Diet; Dietary Supplements; Doublecortin Prote | 2007 |
A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats.
Topics: Age Factors; Animal Feed; Animals; Anxiety; Betaine; Brain; Choline; Critical Period, Psychological; | 2007 |
In utero methanesulfonyl fluoride differentially affects learning and maze performance in the absence of long-lasting cholinergic changes in the adult rat.
Topics: Acetylcholinesterase; Animals; Anxiety; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibit | 2008 |
Prenatal choline supplementation increases sensitivity to time by reducing non-scalar sources of variance in adult temporal processing.
Topics: Analysis of Variance; Animals; Choice Behavior; Choline; Dietary Supplements; Female; Male; Mental P | 2007 |
Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Choline; Conditioning, Psychological; Dietary Supplem | 2008 |
Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Bungarotoxi | 2008 |
Ventilation-induced release of phosphatidylcholine from neonatal-rat lungs in vitro.
Topics: Animals; Animals, Newborn; Calcium; Choline; Diabetes Mellitus, Experimental; Female; Lung; Models, | 1984 |
Alterations in hippocampal hemicholinium-3 binding and related behavioural and biochemical changes after prenatal phenobarbitone exposure.
Topics: Animals; Behavior, Animal; Choline; Female; Hippocampus; Male; Maze Learning; Mice; Phenobarbital; P | 1995 |
Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats.
Topics: Animals; Choline; Choline Deficiency; Dietary Supplements; Female; Hippocampus; In Vitro Techniques; | 1998 |
Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus.
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Choline; Choline Deficiency; Corpus Striatum | 1999 |
The effects of neonatal choline dietary supplementation on adult spatial and configural learning and memory in rats.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Choline; Discrimination Learning; Female; Injections, | 1999 |
Choline supplementation during prenatal development reduces proactive interference in spatial memory.
Topics: Animals; Choice Behavior; Choline; Embryonic and Fetal Development; Female; Fetus; Male; Maze Learni | 1999 |
Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.
Topics: Aging; Animals; Animals, Newborn; Choline; Electric Stimulation; Female; Fetus; Hippocampus; In Vitr | 1999 |
Perinatal complications and abnormal proton metabolite concentrations in frontal cortex of adolescents seen on magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain Damage, Chronic; Choline; Creatine; Female; Follow-Up Studies; Frontal Lobe; Hu | 2000 |
Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood.
Topics: Animals; Carbachol; Choline; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Hippocam | 2000 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Electric Stimulation; Excitatory Postsynaptic Pot | 2000 |
Prenatal choline supplementation protects against postnatal neurotoxicity.
Topics: Aging; Animals; Cell Count; Choline; Cytoprotection; Dietary Supplements; Dizocilpine Maleate; Excit | 2002 |
Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.
Topics: Animals; Choline; Choline Deficiency; Dietary Supplements; Female; Hippocampus; Male; Maze Learning; | 2002 |
Perinatal choline treatment modifies the effects of a visuo-spatial attractive cue upon spatial memory in naive adult rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Brain; Brain Chemistry; Choline; Choline O-Acetyltransfera | 2002 |
Effect of prenatal exposure to phencyclidine on the postnatal development of the cholinergic system in the rat.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Choline; Cholinergic Fibers; Corpus Striatum; Drug T | 1990 |
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus | 1985 |
Prenatal caffeine causes long lasting behavioral and neurochemical changes.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain; Caffeine; Cerebral Cortex; Choline; Discrimina | 1988 |
Prenatal monosodium glutamate causes long-lasting cholinergic and adrenergic changes in various brain regions.
Topics: Animals; Brain; Choline; Choline O-Acetyltransferase; Female; Glutamates; Parasympathetic Nervous Sy | 1987 |