choline has been researched along with Cystic Fibrosis in 14 studies
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choline depletion is seen in cystic fibrosis (CF) and pancreatic insufficiency in spite of enzyme treatment and may result in liver, fatty acid, and muscle abnormalities." | 9.22 | Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial. ( Altes, TA; Dougherty, KA; Elci, O; Hommel, KA; Maqbool, A; Mascarenhas, MR; Moore, J; Schall, JI; Shaw, W; Stallings, VA; Wang, DJ, 2016) |
| "The present study determined the plasma amino acid status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI) in the modern medical and nutritional care setting and investigated the effect of choline supplementation on amino acid status." | 9.22 | Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency. ( Alshaikh, B; Bennett, MJ; Maqbool, A; Mascarenhas, M; Schall, JI; Stallings, VA, 2016) |
| " Despite enzyme substitution, low pancreatic phospholipase A2 (sPLaseA2-IB) activity causes fecal loss of bile phosphatidylcholine and choline deficiency." | 8.02 | Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report. ( Bernhard, W; Graepler-Mainka, U; Grimmel, M; Haack, TB; Machann, J; Shunova, A; Utz, P, 2021) |
| "To investigate relationships between altered plasma choline and PC homeostasis and markers of lung function and inflammation in CF." | 7.81 | Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation. ( Bernhard, W; Grothe, J; Pynn, CJ; Raith, M; Riethmüller, J; Stoll, D; Tschürtz, SM, 2015) |
| "Liver triacylglycerol accumulation and oxidative stress are common in cystic fibrosis (CF) and also occur in choline deficiency." | 7.74 | Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis. ( Davidson, AG; Innis, SM; James, SJ; Melynk, S, 2007) |
| "Choline is an important constituent of acetylcholine." | 6.76 | Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis. ( Bay, BN; Davidson, AG; Hasman, D; Innis, SM; Slack, PJ, 2011) |
| "Choline is a tightly regulated tissue component in the form of phosphatidylcholine (Ptd'Cho) and sphingomyelin (SPH) in all membranes and many secretions, particularly of liver (bile, lipoproteins) and lung (surfactant, lipoproteins)." | 6.72 | Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota. ( Bernhard, W, 2021) |
| "Choline depletion is seen in cystic fibrosis (CF) and pancreatic insufficiency in spite of enzyme treatment and may result in liver, fatty acid, and muscle abnormalities." | 5.22 | Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial. ( Altes, TA; Dougherty, KA; Elci, O; Hommel, KA; Maqbool, A; Mascarenhas, MR; Moore, J; Schall, JI; Shaw, W; Stallings, VA; Wang, DJ, 2016) |
| "The present study determined the plasma amino acid status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI) in the modern medical and nutritional care setting and investigated the effect of choline supplementation on amino acid status." | 5.22 | Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency. ( Alshaikh, B; Bennett, MJ; Maqbool, A; Mascarenhas, M; Schall, JI; Stallings, VA, 2016) |
| " Despite enzyme substitution, low pancreatic phospholipase A2 (sPLaseA2-IB) activity causes fecal loss of bile phosphatidylcholine and choline deficiency." | 4.02 | Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report. ( Bernhard, W; Graepler-Mainka, U; Grimmel, M; Haack, TB; Machann, J; Shunova, A; Utz, P, 2021) |
| "To investigate relationships between altered plasma choline and PC homeostasis and markers of lung function and inflammation in CF." | 3.81 | Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation. ( Bernhard, W; Grothe, J; Pynn, CJ; Raith, M; Riethmüller, J; Stoll, D; Tschürtz, SM, 2015) |
| "Liver triacylglycerol accumulation and oxidative stress are common in cystic fibrosis (CF) and also occur in choline deficiency." | 3.74 | Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis. ( Davidson, AG; Innis, SM; James, SJ; Melynk, S, 2007) |
| "Choline is an important constituent of acetylcholine." | 2.76 | Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis. ( Bay, BN; Davidson, AG; Hasman, D; Innis, SM; Slack, PJ, 2011) |
| "Choline is a tightly regulated tissue component in the form of phosphatidylcholine (Ptd'Cho) and sphingomyelin (SPH) in all membranes and many secretions, particularly of liver (bile, lipoproteins) and lung (surfactant, lipoproteins)." | 2.72 | Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota. ( Bernhard, W, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bernhard, W | 3 |
| Shunova, A | 1 |
| Machann, J | 1 |
| Grimmel, M | 1 |
| Haack, TB | 1 |
| Utz, P | 1 |
| Graepler-Mainka, U | 1 |
| Sun, Z | 1 |
| Kang, Y | 1 |
| Norris, MH | 1 |
| Troyer, RM | 1 |
| Son, MS | 1 |
| Schweizer, HP | 1 |
| Dow, SW | 1 |
| Hoang, TT | 1 |
| Grothe, J | 1 |
| Riethmüller, J | 1 |
| Tschürtz, SM | 1 |
| Raith, M | 1 |
| Pynn, CJ | 1 |
| Stoll, D | 1 |
| Schall, JI | 2 |
| Mascarenhas, MR | 1 |
| Maqbool, A | 3 |
| Dougherty, KA | 1 |
| Elci, O | 1 |
| Wang, DJ | 1 |
| Altes, TA | 1 |
| Hommel, KA | 1 |
| Shaw, W | 1 |
| Moore, J | 1 |
| Stallings, VA | 2 |
| Alshaikh, B | 1 |
| Mascarenhas, M | 2 |
| Bennett, MJ | 1 |
| Scoffield, J | 1 |
| Silo-Suh, L | 1 |
| Michel, SH | 1 |
| Hanna, MD | 1 |
| Innis, SM | 2 |
| Davidson, AG | 2 |
| Bay, BN | 1 |
| Slack, PJ | 1 |
| Hasman, D | 1 |
| Roth, EK | 1 |
| Hirtz, S | 1 |
| Duerr, J | 1 |
| Wenning, D | 1 |
| Eichler, I | 1 |
| Seydewitz, HH | 1 |
| Amaral, MD | 1 |
| Mall, MA | 1 |
| Günther, T | 1 |
| Melynk, S | 1 |
| James, SJ | 1 |
| Ulane, MM | 1 |
| Butler, JD | 1 |
| Peri, A | 1 |
| Miele, L | 1 |
| Ulane, RE | 1 |
| Hubbard, VS | 1 |
| Krieg, DP | 1 |
| Bass, JA | 1 |
| Mattingly, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Choline Nutritional Status Of Children With Cystic Fibrosis X-Sectional Study[NCT01150136] | 57 participants (Actual) | Observational | 2007-10-31 | Completed | |||
| A Randomized, Single-Blind, Placebo-Controlled Trial for the Role of a Dietary Supplement in Lowering S-Adenosylhomocysteine (SAH) in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels and Identification of Participants With Elevated P[NCT05994794] | 40 participants (Actual) | Interventional | 2022-12-09 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for choline and Cystic Fibrosis
| Article | Year |
|---|---|
Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.
Topics: Adult; Child; Choline; Cystic Fibrosis; Gastrointestinal Microbiome; Humans; Liver; Pancreas; Phosph | 2021 |
Nutrition management of pediatric patients who have cystic fibrosis.
Topics: Adolescent; Adult; Child; Child, Preschool; Choline; Cystic Fibrosis; Dietary Proteins; Energy Intak | 2009 |
Mechanisms, regulation and pathologic significance of Mg2+ efflux from erythrocytes.
Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Animals; Antiporters; Chlorides; Choline; Cystic Fibros | 2006 |
4 trials available for choline and Cystic Fibrosis
| Article | Year |
|---|---|
Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Child; Child Nutritional Physiological P | 2016 |
Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency.
Topics: Adolescent; Amino Acids; Amino Acids, Branched-Chain; Child; Child, Preschool; Choline; Cystic Fibro | 2016 |
Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis.
Topics: Acetylcholine; Adolescent; Betaine; Child; Child, Preschool; Choline; Cross-Sectional Studies; Cysti | 2011 |
Cystic fibrosis and phosphatidylcholine biosynthesis.
Topics: Base Sequence; Blood Platelets; Cells, Cultured; Choline; Cyclic AMP; Cystic Fibrosis; Dinoprostone; | 1994 |
7 other studies available for choline and Cystic Fibrosis
| Article | Year |
|---|---|
Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report.
Topics: Child, Preschool; Choline; Choline Deficiency; Cystic Fibrosis; Fatty Liver; Female; Humans; Young A | 2021 |
Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.
Topics: 3-Hydroxyacyl-CoA Dehydrogenase; Amino Acid Sequence; Animals; Bacterial Proteins; Choline; Cystic F | 2014 |
Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation.
Topics: Adult; Arachidonic Acid; Betaine; Choline; Cystic Fibrosis; Deuterium; Docosahexaenoic Acids; Female | 2015 |
Glycerol metabolism promotes biofilm formation by Pseudomonas aeruginosa.
Topics: Biofilms; Choline; Cystic Fibrosis; Glycerol; Humans; Pseudomonas aeruginosa; Pseudomonas Infections | 2016 |
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.
Topics: Adolescent; Adult; Benzimidazoles; Biopsy; Calcium; Child; Child, Preschool; Chlorides; Choline; Cyc | 2011 |
Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis.
Topics: Adolescent; Child; Child, Preschool; Choline; Cystic Fibrosis; Dietary Supplements; Female; Glutathi | 2007 |
Phosphorylcholine stimulates capsule formation of phosphate-limited mucoid Pseudomonas aeruginosa.
Topics: Alginates; Choline; Cystic Fibrosis; Extracellular Space; Glucuronic Acid; Hexuronic Acids; Microsco | 1988 |