choline has been researched along with Chromosomal Triplication in 6 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results indicate that the TS16 condition in mice significantly modified the cholinergic function in brain, and to a lesser degree in spinal cord, suggesting that the higher gene dosage inherent to the trisomic condition affects cholinergic neurons in different regions of the central nervous system in a differential fashion." | 5.29 | Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). ( Caviedes, P; Caviedes, R; Epstein, CJ; Fiedler, JL; Rapoport, SI, 1994) |
| "Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration." | 3.80 | Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014) |
| "Murine trisomy 16 is an animal model of human Down's syndrome." | 1.31 | Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice. ( Allen, DD; Arriagada, C; Cárdenas, AM; Caviedes, P; Caviedes, R; Martín, J; Rapoport, SI, 2000) |
| " The results indicate that the TS16 condition in mice significantly modified the cholinergic function in brain, and to a lesser degree in spinal cord, suggesting that the higher gene dosage inherent to the trisomic condition affects cholinergic neurons in different regions of the central nervous system in a differential fashion." | 1.29 | Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). ( Caviedes, P; Caviedes, R; Epstein, CJ; Fiedler, JL; Rapoport, SI, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ash, JA | 1 |
| Velazquez, R | 1 |
| Kelley, CM | 1 |
| Powers, BE | 1 |
| Ginsberg, SD | 1 |
| Mufson, EJ | 1 |
| Strupp, BJ | 1 |
| Cárdenas, AM | 4 |
| Arriagada, C | 3 |
| Allen, DD | 4 |
| Caviedes, R | 5 |
| Cortes, JF | 1 |
| Martin, J | 2 |
| Couve, E | 1 |
| Rapoport, SI | 4 |
| Shimahara, T | 1 |
| Caviedes, P | 5 |
| Opazo, P | 1 |
| Saud, K | 1 |
| de Saint Pierre, M | 1 |
| Segura-Aguilar, J | 2 |
| Fiedler, JL | 1 |
| Epstein, CJ | 1 |
| Olivares, A | 1 |
| Bennett, LB | 1 |
| Dagnino-Subiabre, A | 1 |
| Mendoza, IE | 1 |
6 other studies available for choline and Chromosomal Triplication
| Article | Year |
|---|---|
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.
Topics: Aging; Animals; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Supple | 2014 |
Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors.
Topics: Animals; Cell Line; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Syndrome; Fem | 2002 |
Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome.
Topics: Acetylcholine; Algorithms; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cell Line; Ce | 2006 |
Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome).
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cells, Cultured; Central Nervous System; Choline; Dise | 1994 |
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cerebral Cortex; Choline; Choline O-Acetyltran | 2000 |
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.
Topics: Acetylcholine; Animals; Calcium; Calcium Signaling; Cell Culture Techniques; Cell Line, Transformed; | 2002 |