choline has been researched along with Cell Transformation, Neoplastic in 51 studies
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choline deficiency causes hepatocyte proliferation, apoptosis and transformation." | 4.79 | Choline. A nutrient that is involved in the regulation of cell proliferation, cell death, and cell transformation. ( Zeisel, SH, 1996) |
| " Previously, we reported a dietary mouse NASH model with a choline-deficient, methionine-lowered, L-amino-acid-defined, high-fat diet containing shortening without trans fatty acids (CDAA-HF-T[-]), which rapidly induces fibrosis and proliferative lesions in the liver." | 4.31 | Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes. ( Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M, 2023) |
| "In this study, a panel of normal human prostate cells (HPCs) and tumor cells derived from metastases were studied by (1)H NMR spectroscopy to determine whether the malignant transformation of HPCs results in the elevation of choline compounds." | 3.71 | Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. ( Ackerstaff, E; Bhujwalla, ZM; Nelson, JB; Pflug, BR, 2001) |
| "This is especially true for prostate cancer, a disease that is characterized by increasing DNA methylation changes with increasing grade of the cancer." | 1.38 | Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence. ( Carducci, MA; Herman, JG; Shabbeer, S; Simons, BW; Williams, SA, 2012) |
| "Necrosis was present histologically in four of the five meningiomas classified either as atypical or papillary." | 1.30 | Noninvasive evaluation of the malignant potential of intracranial meningiomas performed using proton magnetic resonance spectroscopy. ( Handa, J; Inubushi, T; Matsuda, M; Morikawa, S; Nakasu, S; Shino, A, 1999) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (47.06) | 18.7374 |
| 1990's | 10 (19.61) | 18.2507 |
| 2000's | 6 (11.76) | 29.6817 |
| 2010's | 10 (19.61) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki-Kemuriyama, N | 1 |
| Abe, A | 1 |
| Nakane, S | 1 |
| Yuki, M | 1 |
| Miyajima, K | 1 |
| Nakae, D | 1 |
| Ikawa-Yoshida, A | 1 |
| Matsuo, S | 1 |
| Kato, A | 1 |
| Ohmori, Y | 1 |
| Higashida, A | 1 |
| Kaneko, E | 1 |
| Matsumoto, M | 1 |
| Trousil, S | 1 |
| Kaliszczak, M | 1 |
| Schug, Z | 1 |
| Nguyen, QD | 1 |
| Tomasi, G | 1 |
| Favicchio, R | 1 |
| Brickute, D | 1 |
| Fortt, R | 1 |
| Twyman, FJ | 1 |
| Carroll, L | 1 |
| Kalusa, A | 1 |
| Navaratnam, N | 1 |
| Adejumo, T | 1 |
| Carling, D | 1 |
| Gottlieb, E | 1 |
| Aboagye, EO | 2 |
| Rein-Fischboeck, L | 1 |
| Pohl, R | 1 |
| Haberl, EM | 1 |
| Zimny, S | 1 |
| Neumann, M | 1 |
| Eisinger, K | 1 |
| Weiss, TS | 1 |
| Krautbauer, S | 1 |
| Buechler, C | 1 |
| Oakman, C | 1 |
| Tenori, L | 1 |
| Biganzoli, L | 1 |
| Santarpia, L | 1 |
| Cappadona, S | 1 |
| Luchinat, C | 1 |
| Di Leo, A | 1 |
| Slaets, D | 1 |
| De Bruyne, S | 1 |
| Dumolyn, C | 1 |
| Moerman, L | 1 |
| Mertens, K | 1 |
| De Vos, F | 1 |
| Schroeder, RP | 1 |
| van Weerden, WM | 1 |
| Krenning, EP | 1 |
| Bangma, CH | 1 |
| Berndsen, S | 1 |
| Grievink-de Ligt, CH | 1 |
| Groen, HC | 1 |
| Reneman, S | 1 |
| de Blois, E | 1 |
| Breeman, WA | 1 |
| de Jong, M | 1 |
| Glunde, K | 2 |
| Bhujwalla, ZM | 3 |
| Ronen, SM | 1 |
| Shabbeer, S | 1 |
| Williams, SA | 1 |
| Simons, BW | 1 |
| Herman, JG | 1 |
| Carducci, MA | 1 |
| Jiang, L | 1 |
| Wijnen, JP | 1 |
| Jiménez, B | 1 |
| Mirnezami, R | 1 |
| Kinross, J | 1 |
| Cloarec, O | 1 |
| Keun, HC | 1 |
| Holmes, E | 1 |
| Goldin, RD | 1 |
| Ziprin, P | 1 |
| Darzi, A | 1 |
| Nicholson, JK | 1 |
| Ziegler, RG | 1 |
| Lim, U | 1 |
| Inoue, Y | 1 |
| Asanuma, T | 1 |
| Smith, N | 1 |
| Saunders, D | 1 |
| Oblander, J | 1 |
| Kotake, Y | 1 |
| Floyd, RA | 1 |
| Towner, RA | 1 |
| Kubota, K | 1 |
| Soeda, J | 1 |
| Misawa, R | 1 |
| Mihara, M | 1 |
| Miwa, S | 1 |
| Ise, H | 1 |
| Takahashi, M | 1 |
| Miyagawa, S | 1 |
| Hoffman, RM | 1 |
| Fisher, PB | 1 |
| Miranda, AF | 1 |
| Mufson, RA | 1 |
| Weinstein, LS | 1 |
| Fujiki, H | 1 |
| Sugimura, T | 1 |
| Weinstein, IB | 1 |
| Pryme, IF | 3 |
| Lillehaug, JR | 2 |
| Fjose, A | 1 |
| Kleppe, K | 1 |
| Svardal, AM | 1 |
| Skorve, J | 1 |
| Zeisel, SH | 1 |
| Tedeschi, G | 1 |
| Lundbom, N | 1 |
| Raman, R | 1 |
| Bonavita, S | 1 |
| Duyn, JH | 1 |
| Alger, JR | 1 |
| Di Chiro, G | 1 |
| Shino, A | 1 |
| Nakasu, S | 1 |
| Matsuda, M | 1 |
| Handa, J | 1 |
| Morikawa, S | 1 |
| Inubushi, T | 1 |
| Lehman-McKeeman, LD | 1 |
| Gamsky, EA | 1 |
| Ackerstaff, E | 1 |
| Pflug, BR | 1 |
| Nelson, JB | 1 |
| Ramírez de Molina, A | 1 |
| Rodríguez-González, A | 1 |
| Penalva, V | 1 |
| Lucas, L | 1 |
| Lacal, JC | 1 |
| Bader, AV | 1 |
| Bader, JP | 2 |
| Kim, BS | 1 |
| Rowley, DA | 1 |
| Mallat, L | 1 |
| Hale, AH | 1 |
| Pessin, JE | 1 |
| Palmer, F | 1 |
| Weber, MJ | 1 |
| Glaser, M | 1 |
| Fontaine, RN | 2 |
| Schroeder, F | 3 |
| Doi, O | 2 |
| Lee, E | 1 |
| Punnonen, K | 1 |
| Cheng, C | 1 |
| Glick, A | 1 |
| Dlugosz, A | 1 |
| Yuspa, SH | 1 |
| Fu, T | 1 |
| Okano, Y | 1 |
| Nozawa, Y | 1 |
| Locker, J | 1 |
| Teegarden, D | 1 |
| Taparowsky, EJ | 1 |
| Kent, C | 1 |
| Wang, JH | 1 |
| Hinrichsen, LI | 1 |
| Whitacre, CM | 1 |
| Cechner, RL | 1 |
| Sudilovsky, O | 1 |
| Li, DH | 1 |
| Xu, DC | 1 |
| Chandar, N | 1 |
| Lombardi, B | 1 |
| Randerath, K | 1 |
| Male, R | 1 |
| Djurhuus, R | 1 |
| Onodera, K | 1 |
| Okubo, A | 1 |
| Yasumoto, K | 1 |
| Suzuki, T | 1 |
| Kimura, G | 1 |
| Nomoto, K | 1 |
| Ben-Sasson, Z | 1 |
| Weiss, DW | 1 |
| Doljanski, F | 1 |
| Prasad, KN | 1 |
| Diringer, H | 3 |
| Marggraf, WD | 2 |
| Koch, MA | 3 |
| Anderer, FA | 2 |
| Chiarugi, VP | 1 |
| Urbano, P | 1 |
| Pasternak, CA | 1 |
| Micklem, KJ | 1 |
| Ruggieri, S | 1 |
| Collins, JJ | 1 |
| Black, PH | 1 |
| Plagemann, PG | 1 |
| Richey, DP | 1 |
| Peterson, AR | 1 |
| Bertram, JS | 1 |
| Heidelberger, C | 1 |
| Vance, DE | 1 |
| Burke, DC | 1 |
6 reviews available for choline and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Uncovering the metabolomic fingerprint of breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Transformation, Neoplastic; Choline; Female; Glycolysis; H | 2011 |
Choline metabolism in malignant transformation.
Topics: Animals; Cell Transformation, Neoplastic; Choline; Humans; Magnetic Resonance Spectroscopy; Neoplasm | 2011 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Trans | 1984 |
Choline. A nutrient that is involved in the regulation of cell proliferation, cell death, and cell transformation.
Topics: Animals; Cell Death; Cell Division; Cell Line; Cell Transformation, Neoplastic; Choline; Choline Def | 1996 |
Gene amplification during stages of carcinogenesis.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Choline; Cocarcinogenesis; Diet; Gene Ampli | 1991 |
Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; Cell Transfo | 1974 |
45 other studies available for choline and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline D | 2023 |
Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Di | 2017 |
The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.
Topics: Aminopyridines; Animals; Apoptosis; Cell Line, Tumor; Cell Membrane; Cell Transformation, Neoplastic | 2016 |
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Topics: Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Choline; Diet, | 2017 |
Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization.
Topics: Animals; Artifacts; Biological Transport; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemica | 2010 |
Gastrin-releasing peptide receptor-based targeting using bombesin analogues is superior to metabolism-based targeting using choline for in vivo imaging of human prostate cancer xenografts.
Topics: Animals; Bombesin; Cell Line, Tumor; Cell Transformation, Neoplastic; Choline; Fluorine Radioisotope | 2011 |
Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Choline; Dec | 2012 |
Malignant transformation: the role of MRS.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Choline; Diagnosis, Computer-Assisted; Glucose; | 2012 |
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers, Tumor; Cell Transformation, | 2013 |
One-carbon metabolism, colorectal carcinogenesis, chemoprevention--with caution.
Topics: Animals; Betaine; Carbon; Cell Transformation, Neoplastic; Chemoprevention; Choline; Colorectal Neop | 2007 |
Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Cyclic N-Oxides; D | 2007 |
Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model.
Topics: Animal Feed; Animals; Bone Marrow Cells; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2008 |
Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism.
Topics: Adenoviruses, Human; Alkaloids; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; | 1982 |
The nuclear-associated endoplasmic reticulum is an early target for the action of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in C3H/10T1/2 fibroblasts.
Topics: Animals; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Choline; Endoplasmic Reticu | 1983 |
Variation in microsomal subfractions obtained from normal animal tissues and transformed cells following cell disruption by nitrogen cavitation.
Topics: Animals; Carcinoma, Krebs 2; Cell Fractionation; Cell Line; Cell Transformation, Neoplastic; Cells, | 1981 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells.
Topics: Breast; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Choline; Epithelial Cells; Female | 1999 |
Noninvasive evaluation of the malignant potential of intracranial meningiomas performed using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Nuclear; Biomarkers, Tumor; Brain; Cell Division; Cell Tra | 1999 |
Choline supplementation inhibits diethanolamine-induced morphological transformation in syrian hamster embryo cells: evidence for a carcinogenic mechanism.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Choli | 2000 |
Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells.
Topics: Androgens; Cell Line; Cell Transformation, Neoplastic; Choline; Epithelial Cells; Humans; Male; Neop | 2001 |
Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Choline; Choline Kinase; | 2001 |
Transformation of cells by rous sarcoma virus: cytoplasmic vacuolization.
Topics: Adenine; Animals; Avian Sarcoma Viruses; Carbohydrates; Cell Transformation, Neoplastic; Cells, Cult | 1976 |
Specific antigens inhibit plasmacytoma cells bearing phosphorylcholine-binding myeloma proteins.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Choline; Epitopes; Fluorescent Antibody Tec | 1978 |
Sodium: a regulator of glucose uptake in virus-transformed and nontransformed cells.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Choline; D | 1976 |
Modification of the lipid composition of normal and Rous sarcoma virus-infected cells. Effects on transformation-associated membrane properties.
Topics: Animals; Avian Sarcoma Viruses; Biological Transport, Active; Cell Adhesion; Cell Division; Cell Mem | 1977 |
Plasma membrane aminophospholipid distribution in transformed murine fibroblasts.
Topics: Animals; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Choline; Fibroblasts; Imidoester | 1979 |
Retention of acyl groups in LM cell fibroblasts with altered phospholipid composition.
Topics: Acetates; Cell Line; Cell Transformation, Neoplastic; Choline; Fatty Acids; Fatty Acids, Unsaturated | 1978 |
Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype.
Topics: Aluminum; Aluminum Compounds; Animals; Calcium; Cell Differentiation; Cell Division; Cell Transforma | 1992 |
Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine bre
Topics: 3T3 Cells; Animals; Bradykinin; Calcium; Cell Line, Transformed; Cell Transformation, Neoplastic; Ch | 1992 |
Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene.
Topics: Animals; Carbon Radioisotopes; Cell Transformation, Neoplastic; Cells, Cultured; Choline; Choline Ki | 1990 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Persistent reduction of indigenous DNA modification (I-compound) levels in liver DNA from male Fischer rats fed choline-devoid diet and in DNA of resulting neoplasms.
Topics: Animals; Autoradiography; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Diet; Diseas | 1990 |
In vitro transformation and tumor promotion studies of styrene and styrene oxide.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Choline; Cocarcinogenesis; DNA; Endoplasmic Ret | 1985 |
31P nuclear magnetic resonance analysis of lung cancer: the perchloric acid extract spectrum.
Topics: Adenoviridae; Aged; Antibodies, Monoclonal; Cell Line; Cell Transformation, Neoplastic; Choline; Fem | 1986 |
Membrane phospholipids alter nutrient transport and drug toxicity in tumorigenic fibroblasts.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Line; Cell Membrane Permea | 1987 |
Specific binding of factor(s) released by Rous sarcoma virus-transformed cells to splenocytes of chickens with Rous sarcomas.
Topics: Animals; Antigens, Neoplasm; Avian Sarcoma Viruses; Azides; Binding Sites, Antibody; Cell Membrane; | 1974 |
Differentiation of neuroblastoma cells induced in culture by 6-thioguanine.
Topics: Acetyltransferases; Animals; Bromodeoxyuridine; Carbon Radioisotopes; Catechol O-Methyltransferase; | 1973 |
Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells.
Topics: Acetates; Animals; Autoradiography; Cell Transformation, Neoplastic; Choline; Chromatography, Thin L | 1972 |
Studies on cell-coat macromolecules in normal and virus-transformed BHK 21-C13 cells.
Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Carbohydrate Metabolism; Carbon Isotopes; Cell Line; Ce | 1973 |
Permeability changes during cell fusion.
Topics: Animals; Ascites; Calcium; Carbon Radioisotopes; Cell Fusion; Cell Transformation, Neoplastic; Choli | 1973 |
Further investigations of the expression of SV40-induced surface antigens subsequent to enzymatic treatment of transformed cells.
Topics: Animals; Antigens, Viral; Binding Sites, Antibody; Calcium; Carbon Radioisotopes; Cell Line; Cell Tr | 1974 |
Biosynthesis of sphingomyelin. Transfer of phosphorylcholine from phosphatidylcholine to erythro-ceramide in a cell-free system.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell-Free System; Ceramides; Choline; Chromatog | 1973 |
[Biosynthesis of sphingomyelin].
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Choline; Cytosine Nucleotides; Glycerol; | 1972 |
DNA damage and its repair in transformable mouse fibroblasts treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Carbon Radioisotopes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Centrifuga | 1974 |
Inhibition of 3-sn-phosphatidylcholine biosynthesis in baby-hamster kidney-21 cells infected with Semliki Forest virus.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Choline; C | 1974 |