Page last updated: 2024-10-16

choline and Cardiomegaly

choline has been researched along with Cardiomegaly in 8 studies

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis."7.83Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016)
"Although inadequate intake of essential nutrient choline has been known to significantly increase cardiovascular risk, whether additional supplement of choline offering a protection against cardiac hypertrophy remain unstudied."7.79Choline protects against cardiac hypertrophy induced by increased after-load. ( Du, Z; Wang, C; Wang, Y; Wu, J; Zhang, Y; Zhao, Y; Zhu, W, 2013)
"Choline treatment partly restored the DMRs in SHRs, which were related to 131 genes."5.51Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats. ( He, X; Liu, J; Liu, L; Wang, S; Yang, S; Yu, X; Zang, W; Zhao, M, 2019)
"However, the effect of choline on cardiac hypertrophy is not fully understood."5.38Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. ( Du, ZM; Han, HM; Hang, PZ; Jiang, YN; Liu, Y; Pan, ZW; Song, HX; Sun, LH; Wang, S, 2012)
"2% adenine diet for 14 weeks developed CKD with elevated plasma levels of TMAO, provision of a non-lethal inhibitor of gut microbial trimethylamine (TMA) production, iodomethylcholine (IMC), significantly reduced multiple markers of renal injury (plasma creatinine, cystatin C, FGF23, and TMAO), reduced histopathologic evidence of fibrosis, and markedly attenuated development of microalbuminuria."4.02Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. ( Charugundla, S; Guo, F; Hazen, SL; Jia, X; Kaczor-Urbanowicz, KE; Lusis, AJ; Magyar, C; Miikeda, A; Nicholas, SB; Pellegrini, M; Shih, DM; Wang, Z; Zhang, W; Zhou, Z; Zuckerman, J, 2021)
"Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis."3.83Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016)
"Although inadequate intake of essential nutrient choline has been known to significantly increase cardiovascular risk, whether additional supplement of choline offering a protection against cardiac hypertrophy remain unstudied."3.79Choline protects against cardiac hypertrophy induced by increased after-load. ( Du, Z; Wang, C; Wang, Y; Wu, J; Zhang, Y; Zhao, Y; Zhu, W, 2013)
"Choline treatment partly restored the DMRs in SHRs, which were related to 131 genes."1.51Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats. ( He, X; Liu, J; Liu, L; Wang, S; Yang, S; Yu, X; Zang, W; Zhao, M, 2019)
"However, the effect of choline on cardiac hypertrophy is not fully understood."1.38Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. ( Du, ZM; Han, HM; Hang, PZ; Jiang, YN; Liu, Y; Pan, ZW; Song, HX; Sun, LH; Wang, S, 2012)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (87.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Zhang, W1
Miikeda, A1
Zuckerman, J1
Jia, X1
Charugundla, S1
Zhou, Z1
Kaczor-Urbanowicz, KE1
Magyar, C1
Guo, F1
Wang, Z2
Pellegrini, M1
Hazen, SL2
Nicholas, SB1
Lusis, AJ1
Shih, DM1
Liu, L2
He, X2
Zhao, M1
Yang, S1
Wang, S2
Yu, X2
Liu, J1
Zang, W2
Zhao, Y1
Wang, C1
Wu, J1
Wang, Y1
Zhu, W1
Zhang, Y2
Du, Z2
Qi, J1
Tian, S1
Zhang, Z1
Zha, C1
Hang, P1
Organ, CL1
Otsuka, H1
Bhushan, S1
Bradley, J1
Trivedi, R1
Polhemus, DJ1
Tang, WH1
Wu, Y1
Lefer, DJ1
Lu, Y1
Bi, X1
Xu, M1
Xue, R1
English, BA1
Appalsamy, M1
Diedrich, A1
Ruggiero, AM1
Lund, D1
Wright, J1
Keller, NR1
Louderback, KM1
Robertson, D1
Blakely, RD1
Han, HM1
Pan, ZW1
Hang, PZ1
Sun, LH1
Jiang, YN1
Song, HX1
Du, ZM1
Liu, Y1

Reviews

1 review available for choline and Cardiomegaly

ArticleYear
Choline prevents cardiac hypertrophy by inhibiting protein kinase C-δ dependent transient receptor potential canonical 6 channel.
    International journal of cardiology, 2014, Apr-01, Volume: 172, Issue:3

    Topics: Animals; Cardiomegaly; Choline; Humans; Myocardium; Protein Kinase C-delta; TRPC Cation Channels

2014

Other Studies

7 other studies available for choline and Cardiomegaly

ArticleYear
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
    Scientific reports, 2021, 01-12, Volume: 11, Issue:1

    Topics: Adenine; Albuminuria; Animals; Cardiomegaly; Choline; Disease Models, Animal; Female; Fibroblast Gro

2021
Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats.
    Journal of molecular and cellular cardiology, 2019, Volume: 128

    Topics: Animals; Blood Pressure; Cardiomegaly; Choline; Disease Models, Animal; DNA Methylation; Epigenesis,

2019
Choline protects against cardiac hypertrophy induced by increased after-load.
    International journal of biological sciences, 2013, Volume: 9, Issue:3

    Topics: Animals; Calcineurin; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Choline; Down-Regulation; G

2013
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
    Circulation. Heart failure, 2016, Volume: 9, Issue:1

    Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi

2016
Choline ameliorates cardiovascular damage by improving vagal activity and inhibiting the inflammatory response in spontaneously hypertensive rats.
    Scientific reports, 2017, 02-22, Volume: 7

    Topics: Animals; Baroreflex; Cardiomegaly; Cardiovascular Diseases; Choline; Cytokines; Disease Models, Anim

2017
Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:3

    Topics: Age Factors; Analysis of Variance; Animals; Autonomic Nervous System; Blotting, Western; Body Weight

2010
Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:8

    Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Western; Calcineurin; Calcium Signaling; Cardio

2012