choline has been researched along with Cardiomegaly in 8 studies
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 7.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "Although inadequate intake of essential nutrient choline has been known to significantly increase cardiovascular risk, whether additional supplement of choline offering a protection against cardiac hypertrophy remain unstudied." | 7.79 | Choline protects against cardiac hypertrophy induced by increased after-load. ( Du, Z; Wang, C; Wang, Y; Wu, J; Zhang, Y; Zhao, Y; Zhu, W, 2013) |
| "Choline treatment partly restored the DMRs in SHRs, which were related to 131 genes." | 5.51 | Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats. ( He, X; Liu, J; Liu, L; Wang, S; Yang, S; Yu, X; Zang, W; Zhao, M, 2019) |
| "However, the effect of choline on cardiac hypertrophy is not fully understood." | 5.38 | Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. ( Du, ZM; Han, HM; Hang, PZ; Jiang, YN; Liu, Y; Pan, ZW; Song, HX; Sun, LH; Wang, S, 2012) |
| "2% adenine diet for 14 weeks developed CKD with elevated plasma levels of TMAO, provision of a non-lethal inhibitor of gut microbial trimethylamine (TMA) production, iodomethylcholine (IMC), significantly reduced multiple markers of renal injury (plasma creatinine, cystatin C, FGF23, and TMAO), reduced histopathologic evidence of fibrosis, and markedly attenuated development of microalbuminuria." | 4.02 | Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. ( Charugundla, S; Guo, F; Hazen, SL; Jia, X; Kaczor-Urbanowicz, KE; Lusis, AJ; Magyar, C; Miikeda, A; Nicholas, SB; Pellegrini, M; Shih, DM; Wang, Z; Zhang, W; Zhou, Z; Zuckerman, J, 2021) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 3.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "Although inadequate intake of essential nutrient choline has been known to significantly increase cardiovascular risk, whether additional supplement of choline offering a protection against cardiac hypertrophy remain unstudied." | 3.79 | Choline protects against cardiac hypertrophy induced by increased after-load. ( Du, Z; Wang, C; Wang, Y; Wu, J; Zhang, Y; Zhao, Y; Zhu, W, 2013) |
| "Choline treatment partly restored the DMRs in SHRs, which were related to 131 genes." | 1.51 | Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats. ( He, X; Liu, J; Liu, L; Wang, S; Yang, S; Yu, X; Zang, W; Zhao, M, 2019) |
| "However, the effect of choline on cardiac hypertrophy is not fully understood." | 1.38 | Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. ( Du, ZM; Han, HM; Hang, PZ; Jiang, YN; Liu, Y; Pan, ZW; Song, HX; Sun, LH; Wang, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, W | 1 |
| Miikeda, A | 1 |
| Zuckerman, J | 1 |
| Jia, X | 1 |
| Charugundla, S | 1 |
| Zhou, Z | 1 |
| Kaczor-Urbanowicz, KE | 1 |
| Magyar, C | 1 |
| Guo, F | 1 |
| Wang, Z | 2 |
| Pellegrini, M | 1 |
| Hazen, SL | 2 |
| Nicholas, SB | 1 |
| Lusis, AJ | 1 |
| Shih, DM | 1 |
| Liu, L | 2 |
| He, X | 2 |
| Zhao, M | 1 |
| Yang, S | 1 |
| Wang, S | 2 |
| Yu, X | 2 |
| Liu, J | 1 |
| Zang, W | 2 |
| Zhao, Y | 1 |
| Wang, C | 1 |
| Wu, J | 1 |
| Wang, Y | 1 |
| Zhu, W | 1 |
| Zhang, Y | 2 |
| Du, Z | 2 |
| Qi, J | 1 |
| Tian, S | 1 |
| Zhang, Z | 1 |
| Zha, C | 1 |
| Hang, P | 1 |
| Organ, CL | 1 |
| Otsuka, H | 1 |
| Bhushan, S | 1 |
| Bradley, J | 1 |
| Trivedi, R | 1 |
| Polhemus, DJ | 1 |
| Tang, WH | 1 |
| Wu, Y | 1 |
| Lefer, DJ | 1 |
| Lu, Y | 1 |
| Bi, X | 1 |
| Xu, M | 1 |
| Xue, R | 1 |
| English, BA | 1 |
| Appalsamy, M | 1 |
| Diedrich, A | 1 |
| Ruggiero, AM | 1 |
| Lund, D | 1 |
| Wright, J | 1 |
| Keller, NR | 1 |
| Louderback, KM | 1 |
| Robertson, D | 1 |
| Blakely, RD | 1 |
| Han, HM | 1 |
| Pan, ZW | 1 |
| Hang, PZ | 1 |
| Sun, LH | 1 |
| Jiang, YN | 1 |
| Song, HX | 1 |
| Du, ZM | 1 |
| Liu, Y | 1 |
1 review available for choline and Cardiomegaly
| Article | Year |
|---|---|
Choline prevents cardiac hypertrophy by inhibiting protein kinase C-δ dependent transient receptor potential canonical 6 channel.
Topics: Animals; Cardiomegaly; Choline; Humans; Myocardium; Protein Kinase C-delta; TRPC Cation Channels | 2014 |
7 other studies available for choline and Cardiomegaly
| Article | Year |
|---|---|
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
Topics: Adenine; Albuminuria; Animals; Cardiomegaly; Choline; Disease Models, Animal; Female; Fibroblast Gro | 2021 |
Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Choline; Disease Models, Animal; DNA Methylation; Epigenesis, | 2019 |
Choline protects against cardiac hypertrophy induced by increased after-load.
Topics: Animals; Calcineurin; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Choline; Down-Regulation; G | 2013 |
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi | 2016 |
Choline ameliorates cardiovascular damage by improving vagal activity and inhibiting the inflammatory response in spontaneously hypertensive rats.
Topics: Animals; Baroreflex; Cardiomegaly; Cardiovascular Diseases; Choline; Cytokines; Disease Models, Anim | 2017 |
Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter.
Topics: Age Factors; Analysis of Variance; Animals; Autonomic Nervous System; Blotting, Western; Body Weight | 2010 |
Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway.
Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Western; Calcineurin; Calcium Signaling; Cardio | 2012 |